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Social Determinants of Health and Diabetes in Pregnancy Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-19 Christine Field, Xiao-Yu Wang, Maged M. Costantine, Mark B. Landon, William A. Grobman, Kartik K. Venkatesh
Social determinants of health (SDOH) are the conditions in which people are born, grow, work, live, and age. SDOH are systemic factors that may explain, perpetuate, and exacerbate disparities in health outcomes for different populations and can be measured at both an individual and neighborhood or community level (iSDOH, nSDOH). In pregnancy, increasing evidence shows that adverse iSDOH and/or nSDOH
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Identifying Elective Induction of Labor among a Diverse Pregnant Population from Electronic Health Records within a Large Integrated Health Care System Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-19 Fagen Xie, Michael J. Fassett, Theresa M. Im, Daniella Park, Vicki Y. Chiu, Darios Getahun
Objective Distinguishing between medically indicated induction of labor (iIOL) and elective induction of labor (eIOL) is a daunting process for researchers. We aimed to develop a Natural Language Processing (NLP) algorithm to identify eIOLs from electronic health records (EHRs) within a large integrated health care system. Study Design We used structured and unstructured data from Kaiser Permanente
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The Implications of a “Flat” Oral Glucose Tolerance Test Curve in Pregnancy Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-19 Miriam Lopian, Ella Segal, Ran Neiger, Ariel Many, Lior Kashani Ligumsky
Objective This study aimed to determine whether pregnant women who have “flat” oral glucose tolerance test (OGTT) curves in pregnancy are at increased risk of maternal or neonatal adverse outcomes. Study Design We conducted a retrospective cohort study of the perinatal outcomes of pregnant women whose 100-g OGTT curve was “flat,” defined by a fasting serum glucose level below 95 mg/dL and the remaining
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Impact of Patient Safety Bundle and Team-Based Training on Obstetric Hypertensive Emergencies Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-19 Laura Grogan, Erika Peterson, Megan Flatley, Amy Domeyer-Klenske
Objective Hypertensive disorders of pregnancy, defined as chronic (<20 weeks) or gestational (>20 weeks), are a leading cause of pregnancy-related mortality in the United States. Hypertensive disorders of pregnancy had increased prevalence from 13.3 to 15.9% among delivery hospitalizations between 2017 and 2019. The objective of this project was to increase the percentage of obstetric patients with
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Vascular Placental Pathology and Cardiac Structure in Stillborn Fetuses Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-19 Alexa A. Freedman, Tess E.K. Cersonsky, Halit Pinar, Robert L. Goldenberg, Robert M. Silver, Linda M. Ernst
Objective Adverse pregnancy outcomes, including preterm birth and preeclampsia, are associated with worse cardiovascular outcomes for offspring. Examination of the placenta is important for understanding how the prenatal period shapes long-term cardiovascular health. We sought to investigate the association between placental vascular malperfusion and fetal cardiac structure. Study Design Data obtained
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Deimplementation of Routine Maternal Oxygen Supplementation for Intrauterine Fetal Resuscitation: A Retrospective Cohort Study Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-19 Sarah E. Chisholm, Mariella Gastanaduy, Adrem Elmayan, Frank B. Williams
Objective Current practice guidelines for laboring patients with category II intrapartum tracings recommend maternal oxygen supplementation despite emerging randomized data challenging its benefit and utility. We aim to validate that de-implementing maternal oxygen supplementation for fetal resuscitation did not increase the risk of neonatal acidemia in a real-world setting. Study Design This is a
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What Is Culture Made of? An Exploratory Study of Ethical Cultures and Provider Perspectives on the Care of Periviable Neonates Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-19 Shannon Y. Adams, Jessica T. Fry, Natalia Henner
Objective Studies examining intercenter variation in neonatal intensive care unit practices at the limits of fetal viability have hypothesized that institutional “culture” can be one of many factors that impact patient care. This study aimed to describe institutional culture at a single, large academic center with regard to the antenatal consultation, resuscitation, and postnatal management of periviable
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Machine Learning for the Prediction of Surgical Morbidity in Placenta Accreta Spectrum Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Itamar D. Futterman, Olivia Sher, Chaskin Saroff, Alexa Cohen, Georgios Doulaveris, Pe'er Dar, Myah M. Griffin, Meghana Limaye, Thomas Owens, Lois Brustman, Henri Rosenberg, Rebecca Jessel, Scott Chudnoff, Shoshana Haberman
Objective We sought to create a machine learning (ML) model to identify variables that would aid in the prediction of surgical morbidity in cases of placenta accreta spectrum (PAS). Study Design A multicenter analysis including all cases of PAS identified by pathology specimen confirmation, across five tertiary care perinatal centers in New York City from 2013 to 2022. We developed models to predict
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Predictors of Vaginal Delivery among Patients Admitted with Severe Preeclampsia Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Sabrena Myers, Abigail Pyne, Alice Darling, Noor Al-Shibli, Jennifer J.M. Cate, Matthew R. Grace, Sarahn Wheeler, Sarah K. Dotters-Katz
Objective This study aimed to assess the rates of vaginal delivery (VD) and the predictors of VD in a cohort of patients with early (<34 weeks) preeclampsia with severe features (Early Severe PreEClampsia [ESPEC]). Study Design We conducted a retrospective cohort study of patients with ESPEC admitted to a single center from 2013 to 2019. Exclusion criteria included patients with contraindications to
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Evaluation of Gastroesophageal Reflux in Symptomatic Young Infants Using Multichannel Intraluminal pH-Impedance Testing: A large Cohort Study from a Single Center Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Rochelle Sequeira Gomes, Michael Favara, Sheeja Abraham, Joan Di Palma, Zubair H. Aghai
Objectives This study aimed to assess the use of combined multichannel intraluminal impedance and pH studies (MII–pH) in a large group of symptomatic young infants, to characterize the occurrence of gastroesophageal reflux disease (GERD), and to establish temporal association of the reflux behaviors with gastroesophageal reflux using symptom indices. Study Design This is a retrospective cohort study
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Design of a Phase 3, Global, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Yosuke Komatsu, E.J.T. Joanne Verweij, Eleonor Tiblad, Enrico Lopriore, Dick Oepkes, Prasheen Agarwal, Edwin Lam, Jocelyn H. Leu, Leona E. Ling, Robert M. Nelson, Victor Olusajo, Shumyla Saeed-Khawaja, May Lee Tjoa, Jie Zhou, Umair Amin, Waheeda Sirah, Kenneth J. Moise
Objective Nipocalimab is a neonatal fragment crystallizable (Fc) receptor (FcRn)—blocking monoclonal antibody that inhibits placental immunoglobulin G (IgG) transfer and lowers circulating maternal IgG levels. In an open-label, single-arm, phase 2 study, nipocalimab demonstrated evidence of safety and efficacy that support further investigation in a pivotal phase 3 trial of recurrent hemolytic disease
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Neonatal and Maternal Outcomes in Nulliparous Individuals according to Prepregnancy Body Mass Index Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Tetsuya Kawakita, Rula Atwani, George Saade
Objective This study aimed to examine the effect of incremental changes in body mass index (BMI, kg/m2) on the association with adverse pregnancy outcomes. Study Design This was a retrospective cohort study of U.S. vital statistics Live Birth and Infant Death linked data from 2011 to 2020. We limited analyses to nulliparas with singleton pregnancies who delivered at 20 weeks or greater. Outcomes were
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Evaluating the Modified American Academy Pediatrics Screening Algorithm for Critical Congenital Heart Disease. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Hannah Hoff,Sharon Quary,Keesari Rohali,Matthew E Oster
OBJECTIVE In 2018, an expert panel recommended two key modifications to the most used algorithm for screening neonates for critical congenital heart disease (CCHD). Our aim was to evaluate the outcomes of the modified algorithm compared to those of the original algorithm in a real-world setting. STUDY DESIGN We compared the performance characteristics of an original CCHD algorithm used to screen term
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Utilization of a postpartum fasting blood glucose to predict impaired glucose tolerance in patients with gestational diabetes mellitus. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Alissa Kathleen Prior,Cara Dolin,Whitney Renee Bender,Celeste Durnwald,Rebecca F Hamm
OBJECTIVE The Endocrine Society recommends a postpartum fasting blood glucose (FBG) be performed for patients with gestational diabetes mellitus (GDM) prior to hospital discharge to screen for ongoing hyperglycemia. There is limited data, however, on whether a FBG can screen for glucose intolerance and if it correlates with the gold standard 4-to-12-week 2-hour oral glucose tolerance test (OGTT). Our
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Nulliparous Individuals with Class III Obesity: Adverse Outcomes with Labor versus Planned Cesarean Delivery. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-17 Kristen Cagino,Han-Yang Chen,Cabrina Becker,Beverly Red,Suneet P Chauhan,Hector Mendez-Figueroa
Individuals with class III obesity (body mass index [BMI] > 40 kg/m2) are at increased risk of cesarean delivery and peripartum complications. We ascertained compositive neonatal and maternal adverse outcomes among individuals with class III obesity who labored versus had planned cesarean delivery (CD). This was a retrospective cohort study from 2016-2021 using the National Vital Statistics System
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Comparison of Ultrasound Findings Associated with Adverse Fetal, Obstetric, and Neonatal Outcomes in Pregestational Type 1 And Type 2 Diabetes: A Systematic Review. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-13 Alexandria Kraus,Lauren Marie Kucirka,Julie Johnson,Albatoul AbouNouar,Sean V Connelly,Hannah L Thel,Heli S Kavi,Brazil M Bailey,Madelyn K Fox,Kimberly Malloy,Erin Huprich,Jamie L Conklin,Kim Boggess
OBJECTIVE We aimed to summarize the available evidence examining the association between prenatal ultrasound findings and adverse fetal, obstetric, and neonatal outcomes in pregnancies complicated by type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) and to evaluate whether the predictive value of ultrasound findings for adverse outcomes varies between T1DM and T2DM pregnancies. DATA
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A Validated Calculator to Estimate Risk of Chorioamnionitis in Laboring and Induced Patients at Term. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-13 Helen Gomez Slagle,Richard J Caplan,Tetsuya Kawakita,Anthony Sciscione,Matthew Hoffman
OBJECTIVE Chorioamnionitis is associated with neonatal morbidity and infection-related mortality, but our ability to predict intrapartum infection is limited. We sought to derive and validate a prediction model for chorioamnionitis among patients presenting to labor and delivery at term. STUDY DESIGN This was a planned secondary analysis of a large cohort study from 2014 through 2018 at an academic
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Hepatitis C virus infection in pregnant individuals with opioid use disorder and its association with preterm birth. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-11 Aneesha Cheedalla,Marissa Berry,Mahmoud Abdelwahab,Jamie Cowen,Alexandra Stiles,Isabelle Mason,Jonathan R Honegger,Kara Rood
OBJECTIVE Both hepatitis C virus (HCV) and opioid use disorder (OUD) have been associated with higher rates of preterm birth (PTB). It is unknown whether the higher prevalence of HCV in individuals with OUD may contribute to this association. The objective of this study is to evaluate the association between HCV and PTB in pregnant individuals with OUD. STUDY DESIGN We conducted a retrospective cohort
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Pathophysiology of hyponatremia in preterm infants with relative adrenal insufficiency after the early neonatal period. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-11 Mitsuyo Akita,Seiichi Tomotaki,Shintaro Hanaoka,Ryosuke Araki,Kouji Motokura,Yutaro Tomobe,Hiroko Tomotaki,Kougoro Iwanaga,Junko Takita,Masahiko Kawai
Objective Preterm infants often develop relative adrenal insufficiency (RAI) not only within the early neonatal period, but also beyond this period. RAI is commonly accompanied by hyponatremia, but the pathogenesis of hyponatremia with RAI has not been clarified. This study aimed to investigate the pathophysiology of hyponatremia in infants with RAI. Study design This is a single-centered retrospective
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First-Trimester Cell-Free DNA Fetal Fraction and Birth Weight in Twin Pregnancies. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-11 Molly Siegel,Kaitlyn James,Bryann Bromley,Nathanael Koelper,Stephen T Chasen,Laurie B Griffin,Ashley S Roman,Meghana Limaye,Angela Clare Ranzini,Caitlin M Clifford,Joseph Biggio,Akila Subramaniam,Angela Rose Seasely,Jessica Page,Sara Nicholas,Jay Idler,Rashmi Rao,R Shree,Graham McLennan,Lorraine Dugoff
BACKGROUND The relationship between fetal fraction and birth weight in twin gestations is poorly understood. OBJECTIVE To investigate the relationship between first trimester cfDNA fetal fraction and birth weight < 10th percentile in twin gestations. STUDY DESIGN This is a planned secondary analysis of the Twin cfDNA Study, a 17-center retrospective cohort of twin pregnancies screened for aneuploidy
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Defining Research and Care in Diabetes in Pregnancy: Introduction to the Diabetes in Pregnancy Study Group of North America 25th Anniversary Biannual Meeting Special Edition. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-10 Sarah Crimmins,Scott Sullivan,Menachem Miodovnik,E Albert Reece,Kartik K Venkatesh
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Cost Comparison of a Traditional Didactic vs. National Flipped Classroom Curriculum. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-06 Melissa M Carbajal,Heidi Karpen,AnnaMarie Arias,Carly Gisondo,Heather French,Megan Gray,Susan Izatt,Maria Gillam-Krakauer,Lindsay Johnston,Allison Payne,Margarita M Vasquez,Elizabeth M Bonachea,Alison Falck,Patricia Chess,Rita Dadiz
OBJECTIVE We compared the cost of faculty time preparing educational materials for traditional didactic (TD) education provided at local institutions with that of faculty time preparing National Neonatology Curriculum flipped classroom (FC) educational materials shared amongst institutions for fellow education across the United States. STUDY DESIGN Using survey data and the national average for faculty
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Utilization of Immediate Postpartum Contraception and Its Association with Interpregnancy Interval: 10-Year Experience at a Single Center Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-03 Macie L. Champion, Sarah E. Beebe, Christina T. Blanchard, Margaret Boozer, Brian M. Casey, Akila Subramaniam
Objective Increasing availability of immediate postpartum long-acting reversible contraception (LARC) has added contraceptive alternatives to bilateral tubal ligation (BTL) in the immediate postpartum period. The resultant access to long-term contraception has provided patients with improved control over the timing of pregnancies. Our objective is to evaluate changes in the utilization of immediate
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Unintended upper uterine wall extensions at the time of cesarean delivery - risk factors and associated adverse maternal and neonatal outcomes. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-03 Tzuria Peled,Noa Saar,Giulia Muraca,Hen Sela,Sorina Grisaru-Granovsky,Misgav Rottenstreich
OBJECTIVE This study aims to estimate the frequency of unintended upper uterine wall extensions during cesarean delivery (CD) and identify associated risk factors and adverse outcomes. METHODS A multicenter retrospective cohort study was conducted, including patients who underwent CD between 2005 and 2021. Demographic factors, obstetric history, CD indications, delivery and surgical characteristics
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Nulliparous with Class III Obesity at Term: Labor Induction or Cesarean Delivery Without Labor. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-02 Yossi Bart,Rachel L Wiley,Ipsita Ghose,Michal Fishel Bartal,Khalil M Chahine,Suneet P Chauhan,Sean C Blackwell,Baha M Sibai
Objective To compare maternal and neonatal outcomes between labor induction versus CD without labor among nulliparous individuals with class III obesity (body mass index ≥ 40 kg/m2). Study design A retrospective cohort study of all nulliparous singleton deliveries ≥ 37 weeks with a BMI ≥ 40 kg/m2 at delivery between March 2020 and February 2022. We excluded individuals with spontaneous labor, fetal
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Delivery Hospitalization Cardiac and Respiratory Complications during SARS-CoV-2 Delta Variant Dominance. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-09-02 Ruiyan Wang,Alexander Michael Friedman,Whitney Alexandra Booker,Lilly Liu,Timothy Wen
In 2021, the SARS-CoV-2 Delta variant rapidly proliferated and became dominant. Some but not all research evidence supports that Delta was associated with increased maternal risk. The purpose of this study was to determine whether Delta was associated with risk for cardiac and respiratory complications in a national sample. Of an estimated 3,495,188 delivery hospitalizations in 2021, 1.8% of pre-Delta
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The Effect of Self-Reported Race on Noninvasive Prenatal Screening Test Characteristics Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-29 Anjali N. Mitra, Aleksei Dingel, Teodora Kolarova, Hayley J. MacKinnon, Ronit Katz, Christina M. Lockwood, Raj Shree
Objective Low fetal fraction (FF) on cell-free DNA (cfDNA)-based noninvasive prenatal screening (NIPS) is a common etiology for indeterminate results. As maternal Black race is implicated as a risk factor for low FF and more indeterminate results, we sought to evaluate this association. Study Design This was a single-institution, retrospective cohort study of cfDNA-based NIPS performed between May
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Embryonic, Fetal, and Neonatal Complications in Infants of Diabetic Mothers: Insights from the Cincinnati Diabetes in Pregnancy Program Project Grant Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-29 Francis B. Mimouni, Jane C. Khoury, Shelley Ehrlich, Barak M. Rosenn, Galit Sheffer-Mimouni, Menachem Miodovnik
This study aimed to review how the Cincinnati Diabetes in Pregnancy Program Project Grant (PPG) contributed to the understanding and treatment of neonatal complications in infants of diabetic mothers (IDMs). This is a retrospective review of all PPG work on glycemic control at different pregnancy time points and its association with embryonic, fetal, and neonatal complications, such as congenital malformations
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Unraveling the Magnesium Connection: The Cincinnati PPG's Pioneering Work on Mineral Metabolism in Diabetes and Pregnancy Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-29 Francis B. Mimouni, Jane C. Khoury, Shelley Ehrlich, Barak Rosen, Galit Sheffer-Mimouni, Menachem Miodovnik
This study aimed to review the Cincinnati PPG's contribution to the understanding and treatment of neonatal hypocalcemia (NHC) in infants of diabetic mothers. This study is a retrospective review of the NIH-funded Program Project Grant (PPG) works related to mineral metabolism in type 1 diabetic pregnant women. The PPG investigators first described the epidemiology and the additional risk factors for
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Impact of Inpatient Patient–Provider Language Concordance on Exclusive Breastfeeding Rates Postpartum Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-29 Alexandra M. Abbate, Alexander M. Saucedo, Jeny Ghartey, Julia López, Miriam Alvarez, Emily Hall, Elaine Avshman, Odera Okafor, Megan Olshavsky, Lorie M. Harper, Alison G. Cahill
Objective Studies outside of obstetrics suggest that patient–provider language concordance may impact the efficacy of educational interventions and overall patient satisfaction. Many pregnant patients who present to the hospital for delivery with initial plans to exclusively breastfeed ultimately leave the hospital supplementing with formula. We aim to examine the impact of language concordance between
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Diabetes and Early Development: Epigenetics, Biological Stress, and Aging. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-29 Guanglei Wang,Wei-Bin Shen,Anna Wu Chen,E Albert Reece,Peixin Yang
Pregestational diabetes, either type 1 or type 2 diabetes, induces structural birth defects including neural tube defects (NTDs) and congenital heart defects (CHDs) in human fetuses. Rodent models of type 1 and type 2 diabetic embryopathy have been established and faithfully mimic human conditions. Hyperglycemia of maternal diabetes triggers oxidative stress in the developing neuroepithelium and the
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Intrapartum Care for People with Diabetes in Pregnancy - Working Towards Evidence-based Management. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-29 Michal Fishel Bartal
The consensus in the literature supports the need for careful monitoring and management of maternal blood glucose during labor to optimize neonatal outcomes. Guidelines generally recommend strict control of maternal blood glucose during labor, involving frequent checks and the use of dextrose and insulin as needed. However, recent evidence has not consistently shown a strong association between strict
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Daily vs Alternate Day Iron Supplementation for Pregnant Women With Iron Deficiency Anemia: A Randomized Controlled Trial. Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-29 Melissa Chu Lam,Binny Khandakar Khandakar,Isaak Heon,Farrah Hussain,Kristina Martimucci,Elianna Kaplowitz,Jessica Overbey,Lois Brustman,Barak Rosenn
OBJECTIVE Evaluate the most effective regimen to raise hemoglobin by comparing alternate day dosing of iron to daily dosing in pregnant women with iron deficiency anemia. STUDY DESIGN Women with Hb <11.0 g/dl and ferritin 25 ug/L between 12w0d-34w0d gestation were recruited. 88 patients were randomized using block randomization with 1:1 allocation to receive either 1 tablet of 325mg ferrous sulfate
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Safety of Skin-to-Skin Contact with Umbilical Venous Catheter in Preterm Infants: A Prospective Study Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-26 Alicia Montaner-Ramon, Elena Carrillo-Messa, Laura Merayo-Fernandez, Inmaculada Cosmo-Garcia, Isabel Ramos-Soriano, Laura Gonzalez-Garcia, Fatima Camba-Longueira
Objective For many health care providers, an umbilical venous catheter (UVC) may be a contraindication for skin-to-skin contact (SSC). Our aim was to compare the frequency of adverse events between preterm infants who were on SSC with UVC and those who remained in an incubator. Study Design Prospective observational study in newborns less than 35 weeks gestation. UVC-related adverse events were compared
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Comparison of Clinical Endotracheal Tube Depths with Standard Estimates for the Stabilization of Infants with Congenital Diaphragmatic Hernia Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-13 Allison C. Young, Joseph L. Hagan, Shweta S. Parmekar, Pamela M. Ketwaroo, Nathan C. Sundgren
Objective This study aimed to compare the clinical endotracheal tube (ETT) depth after initial stabilization of infants with congenital diaphragmatic hernia (CDH) to weight and gestational age-based depth estimates. Study Design This retrospective analysis included 58 inborn infants with left-sided CDH. We compared a standard anatomic ETT depth calculated from initial chest radiographs and the clinical
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Early-Onset Sepsis as an Early Predictor for Retinopathy of Prematurity: A Meta-analysis Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-13 Salma El Emrani, Lotte E. van der Meeren, Esther J.S. Jansen, Jelle J. Goeman, Jacqueline U.M. Termote, Enrico Lopriore, Nicoline E. Schalij-Delfos
Objective Neonatal sepsis has been established as a risk factor for retinopathy of prematurity (ROP) but previous meta-analyses have predominately focused on late-onset sepsis (LOS). This meta-analysis aims to explore the association between early-onset sepsis (EOS) and the risk of ROP. Study Design Observational studies reporting (unadjusted) data on proven EOS in neonates with ROP were included.
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Impact of the ARRIVE Trial on Stillbirth Rates in Nulliparous Individuals Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-13 Rula Atwani, George Saade, Tetsuya Kawakita
Objective We aim to examine the population-level rates of induction, stillbirth, perinatal mortality, and neonatal death before and after the ARRIVE (A Randomized Trial of Induction Versus Expectant Management) trial. Study Design This study was a cross-sectional analysis of publicly available U.S. Live Birth data linked with Infant Death and Fetal Death certificate data from National Vital Statistics
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Renal Regional Oxygen Saturation and Acute Kidney Injury in Neonates with Perinatal Asphyxia Am. J. Perinatol. (IF 1.5) Pub Date : 2024-08-13 Sergio Agudelo-Pérez, Gloria Troncoso, Daniel Botero-Rosas, Christian Muñoz, Andrés Rodríguez, Andrea Valentina Gómez, Jennifer León
Objective Neonates with moderate-to-severe perinatal asphyxia often develop acute kidney injury (AKI). Additionally, therapeutic hypothermia (TH) can affect renal blood flow. This study aimed to evaluate the association between renal regional oxygen saturation (rSrO2) during TH and AKI in neonates with moderate and severe perinatal asphyxia. Study Design This retrospective longitudinal study included
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Utilizing Fetal Echocardiography to Risk Stratify and Predict Neonatal Outcomes in Fetuses Diagnosed with Congenital Heart Disease Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-29 Sanghee S. Ro, Ian Milligan, Joe Kreeger, Michelle E. Gleason, Andrew Porter, William Border, M. Eric Ferguson, Ritu Sachdeva, Erik Michelfelder
Objective Risk stratification of fetuses diagnosed with congenital heart disease (CHD) helps provide a delivery plan and prepare families and medical teams on expected course in the delivery room. Our aim was to assess the accuracy of echocardiographically determined risk-stratification assignments in predicting postnatal cardiac outcomes beyond the delivery room. Study Design This was a retrospective
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Fetal and Maternal Factors Predictive of Primary Cesarean Delivery at Term in a Low-Risk Population: NICHD Fetal Growth Studies—Singletons Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-29 Julio Mateus, Danielle R. Stevens, Katherine L. Grantz, Cuilin Zhang, Jagteshwar Grewal, William A. Grobman, John Owen, Anthony C. Sciscione, Ronald J. Wapner, Daniel Skupski, Edward Chien, Deborah A. Wing, Angela C. Ranzini, Michael P. Nageotte, Roger B. Newman
Objective This study aimed to examine associations of fetal biometric and amniotic fluid measures with intrapartum primary cesarean delivery (PCD) and develop prediction models for PCD based on ultrasound parameters and maternal factors. Study Design Secondary analysis of the National Institute of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Fetal Growth
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Mental Health Support and Screening for Mood Disorders for Caregivers in the Neonatal Intensive Care Unit: Is the Call to Arms Being Answered? Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-29 Megan Lagoski, Lamia Soghier, Joanne Lagata, Miller Shivers, Erin Sadler, Elizabeth Fischer, Adrienne Borschuk, Melissa House, Children's Hospitals Neonatal Consortium Perinatal Mood Anxiety Disorder Focus Group
Objective Perinatal mood and anxiety disorders (PMADs) affect many neonatal intensive care unit (NICU) parents and are a significant risk factor for maternal suicide. Lack of screening and treatment interferes with infant development and bonding, compounding risks in fragile infants. We aim to describe PMAD screening in level IV NICUs across the Children's Hospitals Neonatal Consortium (CHNC) and to
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Sex-Related Differences in the Severity of Neonatal Opioid Withdrawal Syndrome: A Single-Center, Retrospective Cohort Study Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-29 Victoria A. Anderson, Saminathan Anbalagan, Michael T. Favara, Daniela Stark, David Carola, Kolawole O. Solarin, Susan Adeniyi-Jones, Zubair H. Aghai
Objective Factors associated with the development and expression of Neonatal Opioid Withdrawal Syndrome (NOWS) are poorly understood. There are conflicting data on the role of infant sex in NOWS. Some studies have suggested that infant sex predicts NOWS severity and adverse outcomes, with male infants being more vulnerable. This study aimed to analyze if infant sex is associated with the severity of
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Outcomes in Pregnancies Complicated with Preterm Hypertensive Disorders with and without Late Antenatal Corticosteroids Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-24 Noam Regev, Michal Axelrod, Chen Berkovitz, Rakefet Yoeli-Ulman, Shali Mazaki-Tovi, Eyal Sivan, Baha Sibai, Michal Fishel Bartal
Objective This study aimed to determine whether administration of a late preterm (34–36 weeks) course of antenatal corticosteroids (ACS) is associated with improved short-term neonatal outcomes among pregnancies complicated with hypertensive disorders of pregnancy (HDP) who delivered in the late preterm period. Study Design A single tertiary center retrospective cohort study, including pregnant individuals
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Recurrence Risk of Pregnancy Complications in Twin and Singleton Deliveries Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-23 Marion Granger, Maria Sevoyan, Nansi S. Boghossian
Objective This study aimed to estimate and compare the recurrence risk of preterm birth (PTB), gestational diabetes mellitus (GDM), gestational hypertension (GH), and preeclampsia and eclampsia (PE and E) in subsequent pregnancy groups (index–subsequent) of singleton–singleton (n = 49,868), twin–singleton (n = 448), and singleton–twin (n = 723) pregnancies. Study Design Birthing individuals from the
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Are Neonatal Birth Weights Reduced in Low-Risk Patients Diagnosed with COVID-19 during Pregnancy? Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-23 Hannah S. Foster, Markolline Forkpa, Ximena A. Van Tienhoven, Nadav Schwartz, Sindhu Srinivas, Samuel Parry, Meaghan G. Mccabe
Objective Studies have shown that the 2019 novel coronavirus disease (COVID-19) may be associated with an increased risk of adverse pregnancy outcomes including preeclampsia, preterm birth, and stillbirth. However, the relationship between COVID-19 and abnormal fetal growth (i.e., low neonatal birth weight) has not been elucidated. Because other viruses affect fetal growth, obstetrical providers began
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Affordable Implementation of a Point-of-Care Ultrasound Program in a Large Tertiary Neonatal Intensive Care Unit to Assess Umbilical Venous Catheter Tips and Aid Central Placement Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-19 John T. Wren Jr., Azadeh Eslambolchi, Kristen Clark, Tasnim Najaf
Objective This study aimed to implement a point-of-care ultrasound (POCUS) program into a large neonatal intensive care unit (NICU) to enhance care by improving (1) umbilical venous catheter (UVC) tip identification and (2) central placement. Study Design A POCUS program was established with core providers who received training from external and internal experts. A prospective study (n = 94) compared
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When Are Pregnant Patients Receiving Tranexamic Acid during Delivery Hospitalization in the United States? Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-18 Julia Whitley, Seyedeh A. Miran, Phillip Ma, George Saade, Ian Roberts, Homa K. Ahmadzia
Objective The World Health Organization recommends tranexamic acid (TXA) in the management of postpartum hemorrhage (PPH). However, the role of TXA in PPH prevention and the optimal timing of TXA administration remain unknown. Our objective was to describe the timing of TXA administration, differences in timing of TXA administration by mode of delivery, and current trends in TXA administration in the
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Assessment of Aminoglycoside-Induced Hearing Loss Risk in the Perinatal Period Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-15 Whitney S. Thompson, Leslie Saba, Linda Hasadsri, Sylvie Girard, Lisa A. Schimmenti, Ellen M. Bendel-Stenzel, Myra J. Wick, Jane E. Brumbaugh
Objective This study aimed to determine the prevalence and heteroplasmy level(s) of MT-RNR1 variants m.1555A > G and m.1494C > T, which are associated with aminoglycoside-induced hearing loss, in a general perinatal population. This study also aimed to characterize the association of these variants and their heteroplasmy levels with hearing loss outcomes with and without aminoglycoside exposure. Study
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Reduced Expression of REG4 as a Sign of Altered Goblet Cell Function in Necrotizing Enterocolitis Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-15 Alice Hoffsten, Laszlo Markasz, Helene Engstrand Lilja, Hamid Mobini-Far, Richard Sindelar
Objective Defective Goblet cells have been proposed to be involved in necrotizing enterocolitis (NEC). The aim was to study the expression of the Goblet cell marker REG4 and its potential involvement in NEC in preterm infants with and without NEC. Study Design Seventy histologically intact intestinal biopsies were studied: 43 were collected during surgery due to NEC (NEC group: 26.5 ± 3.0 weeks' gestational
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Maternal Preconception Omega-6, Omega-3, and Omega-6:Omega-3 Intake and Uterine Artery Indices in Mid-Gestation Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-15 Amara Finch, Lisa Joss-Moore, Amanda A. Allshouse, Nathan Blue, David M. Haas, William Grobman, Samuel Parry, George Saade, Robert M. Silver
Objective Maternal preconception diet influences pregnancy health and fetal outcomes. We examined the relationship between preconception fatty acid (FA) intake and uterine artery indices in mid-gestation in a large, heterogeneous cohort of nulliparous individuals. Study Design This is a secondary analysis of the nuMom2b (Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be) study. Dietary
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Placenta and Intestinal Injury in Preterm Infants Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-11 Padma Garg, Jörn-Hendrik Weitkamp, Anna G. McDonald, Sarah N. Cilvik, Imran Mir, Jeffrey S. Shenberger, Oluwabunmi Olaloye, Liza Konnikova, Suhas G. Kallapur, Parvesh M. Garg
Necrotizing enterocolitis (NEC) is one of the most common gastrointestinal conditions affecting 6 to 10% of low-birth-weight infants and remains a leading cause of death. The risk factors associated with NEC are complex and multifactorial, including preterm birth and intrauterine exposure to inflammation and hypoxia. Chorioamnionitis has been associated with intestinal injury in animal and human clinical
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Multivariate Analysis of Factors Associated with Feeding Mother's Own Milk at Discharge in Preterm Infants: A Retrospective Cohort Study Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-11 Jordan D. Reis, Mariela Sánchez-Rosado, Daizy Mathai, Isabelle Kiefaber, L Steven Brown, Cheryl S. Lair, David B. Nelson, Patti Burchfield, Luc P. Brion
Objective This study aimed to develop a predictive model of feeding mother's own milk (MOM) at discharge using social determinants of health (SDOH), maternal and neonatal factors after deliveries at <33 weeks of gestational age (GA), or birth weight <1,500 g. Study Design Secondary analysis of a retrospective cohort in an inner-city hospital before (Epoch-1, 2018–2019) and after (Epoch-2, 2020–2021)
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Influences of a Remote Monitoring Program of Home Nasogastric Tube Feeds on Transition from NICU to Home Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-11 Megan Quinn, Sandra Banta-Wright, Jamie B. Warren
Objective The transition from the neonatal intensive care unit (NICU) to the home is complex and multifaceted for families and infants, particularly those with ongoing medical needs. Our hospital utilizes a remote monitoring program called Growing @ Home (G@H) to support discharge from the NICU with continued nasogastric tube (NGT) feeds. We aim to describe the experience of the transition from NICU
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Pregnancy-related and Neonatal Outcomes during Omicron Variant-Dominant COVID-19 Pandemic among the Black-Dominant Population Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-11 Daniel D. Min, Jae H. Min
Objective This study aimed to determine the effect of the Omicron variant on pregnancy-related and neonatal outcomes among the Black-dominant population. Study Design We performed a single-center, retrospective cohort study during the prepandemic period from December 1, 2019, to February 29, 2020, and the Omicron surging period from December 1, 2021, to February 28, 2022. A total of 518 pregnant women
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Venous Thromboembolism Prophylaxis Should Be Recommended for Antepartum Admissions and Cesarean Delivery if Age and Body Mass Index are Greater Than 35 Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-10 Laurence E. Shields, Daniele Feldman, Catherine Klein, Mindy Foster, Stephanie Lin
Objective Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality. Current expanded treatment recommendations result in the inclusion of a large percentage of the obstetric population, which has limited their adoption. The purpose of this study was to identify a population at high risk for VTE, with minimal impact on the number of patients that would qualify for expanded treatment
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Clinical Characteristics of Necrotizing Enterocolitis Diagnosed by Independent Adjudication of Abdominal Radiographs, Laparotomy, or Autopsy in Preterm Infants in the “Connection Trial” Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-10 Josef Neu, Rachana Singh, Mihaela Demetrian, Jaime Flores-Torres, Mark Hudak, John A. Zupancic, Anders Kronström, Jonas Rastad, Staffan Strömberg, Marcus Thuresson, The “Connection Study” Group
Objective Necrotizing enterocolitis (NEC) classically is diagnosed by radiographic demonstration of pneumatosis intestinalis/portal venous gas (PI/PVG). This study examines clinical characteristics of NEC confirmed by independent evaluation of abdominal radiographs, taken for clinical signs of NEC, or by pathologic findings at laparotomy or autopsy (confirmed NEC [cNEC]). Study Design The investigated
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Genomic Differences between Spontaneous versus Indicated Extreme Preterm Birth Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-10 Namasivayam Ambalavanan, C. Michael Cotten, Stephen W. Erickson, Ravi Mathur, Dara Torgerson, Philip L. Ballard, for the Eunice Kennedy Shriver NICHD Neonatal Research Network and the TOLSURF Study Group
Objective Extremely preterm infants are at high risk of neonatal mortality and morbidity. Extreme preterm birth (PTB) may result from spontaneous preterm labor or preterm premature rupture of membranes or may be indicated due to preeclampsia, eclampsia, hypertension, or other causes. Our objective was to identify single nucleotide polymorphisms (SNPs) and biological pathways associated with spontaneous
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Influence of Pregnancy Intention on Postpartum Contraceptive Choice at an Urban Academic Medical Center Am. J. Perinatol. (IF 1.5) Pub Date : 2024-07-01 Meghan St John, Kirby Sullivan, Emily A. DeFranco, Elizabeth Kelly
Objective This study aimed to describe postpartum contraception preferences in the context of pregnancy intention (PI). Study Design A prospective cohort study analyzing postpartum contraceptive choice (PCC) in 431 postpartum women who delivered at a single academic medical center. PCC in women with an unintended or mistimed pregnancy was compared to contraceptive choice in women with an intended pregnancy
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Respiratory Severity Score and Oxygen Saturation Index during the First 2 Hours of Life as Predictors for Noninvasive Respiratory Support Failure in Respiratory Distress Syndrome Am. J. Perinatol. (IF 1.5) Pub Date : 2024-06-24 Henry A. Zapata, Jack Koueik, Heather L. Becker, Michael R. Lasarev, Scott O. Guthrie, Dinushan C. Kaluarachchi
Objective Noninvasive respiratory support (NRS) failure is common in preterm infants with respiratory distress syndrome (RDS). We evaluated the utility of respiratory severity score (RSS) and oxygen saturation index (OSI) during the first 2 hours of life (HOL) as predictors for NRS failure in moderate preterm infants. Study Design We conducted a retrospective cohort study of infants born between 280/7
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Trends and Outcomes among Pregnancy and Nonpregnancy-Related Hospitalizations with Diabetic Ketoacidosis Am. J. Perinatol. (IF 1.5) Pub Date : 2024-06-24 Ghamar Bitar, Baha M. Sibai, Han-Yang Chen, Sarah A. Nazeer, Suneet P. Chauhan, Sean Blackwell, Michal Fishel Bartal
Objective The study's primary objective was to evaluate adverse outcomes among reproductive-age hospitalizations with diabetic ketoacidosis (DKA), comparing those that are pregnancy-related versus nonpregnancy-related and evaluating temporal trends. Study Design We conducted a retrospective cross-sectional study using the National Inpatient Sample to identify hospitalizations with DKA among reproductive-age