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HIV-Associated Genital Immune Biomarkers in the Female Sex Worker Population: A Pilot Study Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-20 Eleanor Capozzi, Jason Daniels, Hani Mohamed, Fernando Cabezas Mejia, David Sternberg, Jennifer Bouey, Mimi Ghosh
Female sex workers (FSW) experience a disproportionately high burden of HIV infection, yet characterization of the vaginal immune microenvironment that may impact biological risk is not well studied among FSW in the United States. Additionally, feasible methodology for collecting biological materials has not been evaluated in this population.
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Changes in Relative Counts of Different Leukocyte Subpopulations in Peripheral and Umbilical Cord Blood of Women With Preterm Prelabor Rupture of Membranes With Respect to Intraamniotic Inflammation and Fetal Inflammatory Response Syndrome Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-20 Ondrej Soucek, Marian Kacerovsky, Ivana Kacerovska Musilova, Jaroslav Stranik, Rudolf Kukla, Radka Bolehovska, Helena Hornychova, Ctirad Andrys
ObjectiveThe aim of this study was to evaluate changes in the relative counts of different leukocyte subsets in peripheral and umbilical cord blood in pregnancies complicated by preterm prelabor rupture of membranes (PPROM) with respect to the presence of intraamniotic inflammation (IAI) and fetal inflammatory response syndrome (FIRS).MethodsFifty‐two women with singleton pregnancies complicated by
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Is the Transcription Factor NANOG Involved in Placental Aging? Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-20 Sivan Farladansky‐Gershnabel, Michal Silber, Tal Biron‐Shental, Michal Kovo, Debora Kidron, Avivit Weisz, Tali Zitman‐Gal
ProblemAccelerated placental aging is linked to abnormal fetal growth, preeclampsia (PE), and preterm birth (PTB). NANOG, a transcription factor, is known for its role in cellular reprogramming, self‐renewal, and clonogenic growth. Its expression is regulated by Kruppel‐like factor 4 (KLF4), which functions as both a transcriptional activator and repressor. This study evaluated the KLF4‐NANOG pathway
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Viral Infection in Endometritis: Is There an Important Role or Not? Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-20 Hatav Ghasemi Tehrani, Marzieh Rezaei, Ferdous Mehrabian, Elham Naghshineh, Mohsen Moghoofei
Chronic endometritis (CE) is a frequent pathological condition that is defined as localized inflammation in the endometrium. Some adverse fertility consequences such as recurrent miscarriage and failure of implantation are associated with chronic endometritis. On the one hand, inflammation plays an important role in the pathogenesis of endometritis, and on the other hand, the role of viral infections
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Causal Association of Rheumatoid Arthritis With Adverse Pregnancy Outcomes: Genetic Evidence From Mendelian Randomization Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-13 Yixiao Wang, Fengyuan Zhang, Li Xu, Xiaohong Ji, Shanshan Wang, Xiao Shen, Haiyan Chen, Shengyuan Jiang, Chengqian Wu, Min Chen, Hong Yu
ObjectiveAlthough the association of rheumatoid arthritis (RA) to multiple adverse pregnancy outcomes has been well‐studied, the association between serum antibody levels in patients with RA and multiple adverse pregnancy outcomes has not been conclusively demonstrated. Here, we comprehensively assessed the causal impact of RA, serologic antibody‐positive RA (pRA), and serologic antibody‐negative RA
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Correction to “Maternal HLA Class II Alleles and Haplotypes Associated With Altered Risk of Recurrent Pregnancy Loss: A Case‐Control Study” Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-03
G. Aimagambetova, A. Kapasheva, W. Bahia, K. Atageldiyeva, and W. Y. Almawi, “Maternal HLA Class II Alleles and Haplotypes Associated With Altered Risk of Recurrent Pregnancy Loss: A Case-Control Study,” American Journal of Reproductive Immunology, 91 (2024): e13817, https://doi.org/10.1111/aji.13817. Correction on Section 2.1: Study design and study subjects Original Text: “This is a retrospective
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Regional Analysis of the Immune Microenvironment in Human Endometrium Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-03 Lingtao Yang, Yiyi Su, Songchen Cai, Huan Ma, Jing Yang, Mingjuan Xu, Yuye Li, Chunyu Huang, Yong Zeng, Qiyuan Li, Mingqian Feng, Hanjie Li, Lianghui Diao
ProblemEndometrial immune cells are essential for maintaining homeostasis and the endometrial receptivity to embryo implantation. Understanding regional variations in endometrial immune cell populations is crucial for comprehending normal endometrial function and the pathophysiology of endometrial disorders. Despite previous studies focusing on the overall immune cell composition and function in the
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New Immunological Indexes for the Effect of Systemic Inflammation on Oocyte and Embryo Development in Women With Unexplained Infertility: Systemic Immune Response Index and Pan‐Immune‐Inflammation Value Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-02 Serap Topkara Sucu, Berrin Goktuğ Kadioglu, Burak Elmas, Mehmet Caner Ozer, Ulaş Fidan, Mustafa Ozturk, Seyit Temel Ceyhan
ProblemPredicting the impact of systemic inflammation on oocyte and embryonic development in unexplained infertile women using the new immunological indexes.Method of StudyThis retrospective cohort study was conducted using the records of the In Vitro Fertilization Department of Ankara Gülhane Training and Research Hospital. After reviewing the records of patients who had undergone in vitro fertilization
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Systemic Immune‐Inflammation Indices Could Be Additional Predictive Markers for Cesarean Scar Pregnancy Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-09-02 Jing Gao, Nanyan Jiang, Qi Chen, Min Zhao, Yunhui Tang
ProblemCesarean scar pregnancy (CSP) is characterized by a gestational sac fully or partially implanted in the scar from a previous cesarean section. Systemic immune‐inflammation indices (SIIs) have recently been discussed as additional diagnostic markers in placenta accreta and preeclampsia. CSP shares a similar pathogenesis with these diseases, suggesting that assessing the SIIs and neutrophil‐to‐lymphocyte
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Featured Cover Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-23 Federica Giangrazi, Dafne Buffa, Andrew T. Lloyd, Anthony K. Redmond, Louise E. Glover, Cliona O'Farrelly
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Spatial Activation of Autophagy in Human Placenta‐Related Tissue During Labor: A Possible Mechanism for Labor Onset Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-23 Jing Shang, Zhijian Wang, Yingying Huang, Yuyu Wu, Jin Jin
IntroductionTo explore the mechanisms of labor by investigating the autophagy of placental and fetal membranes tissue in normal pregnant women.MethodsPlacenta and fetal membranes were collected from women with singleton pregnancies without any medical complications and from women who delivered vaginally (labor‐initiated group; L group) or by caesarean section (labor‐noninitiated group; NL group). Autophagosomes
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Evolutionary Analysis of the Mammalian IL‐17 Cytokine Family Suggests Conserved Roles in Female Fertility Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-23 Federica Giangrazi, Dafne Buffa, Andrew T. Lloyd, Anthony K. Redmond, Louise E. Glover, Cliona O'Farrelly
ProblemThe interleukin‐17 (IL‐17) family includes pro‐inflammatory cytokines IL‐17A‐F with important roles in mucosal defence, barrier integrity and tissue regeneration. IL‐17A can be dysregulated in fertility complications, including pre‐eclampsia, endometriosis and miscarriage. Because mammalian subclasses (eutherian, metatherian, and prototherian) have different related reproductive strategies,
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IL‐2 and IL‐4 May Reduce the Risk of Pathological Hyperprolactinemia: Genetic Epidemiological Evidence Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-21 Teng Qi, Junhao Wan, Fuqing Ji
Conflicts of Interest The authors declare no conflicts of interest.
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Active Heme Metabolism Suppresses Macrophage Phagocytosis via the TLR4/Type I IFN Signaling/CD36 in Uterine Endometrial Cancer Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-21 Xing Zhang, Yi‐Xing Yang, Jia‐Jing Lu, Ding‐Yu Hou, Ayitila Abudukeyoumu, Hong‐Wei Zhang, Ming‐Qing Li, Feng Xie
BackgroundUterine endometrial cancer (UEC) is a common gynecological estrogen‐dependent carcinoma, usually accompanied by intermenstrual bleeding. Active heme metabolism frequently plays an increasingly important role in many diseases, especially in cancers. Tumor‐associated macrophages (TAMs) are the major population in the immune microenvironment of UEC. However, the roles of heme metabolisms in
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Zishen Qingre Lishi Huayu Recipe May Ameliorate the Symptoms of PCOS Model Rats via Alleviating Systemic and Ovarian Inflammation Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-19 Xin Li, Yao Yi, Yunying Ren, Yixuan Zhang, Chi Chiu Wang, Chengyi Liu, Shuzhen Liu, Xiaoxuan Zhan, Xingxing Yu, Ruining Liang
BackgroundZishen Qingre Lishi Huayu recipe (ZQLHR) has shown significant therapeutic effects in treating sex hormone levels and follicular developmental disorders in patients with polycystic ovary syndrome (PCOS). However, little is known about the potential mechanisms of its treatment.MethodsDehydroepiandrosterone and a high‐fat diet induced the PCOS model rat. The serum of rats was collected to detect
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Long non‐coding RNA TPT1‐AS1 inhibits ferroptosis in ovarian cancer by regulating GPX4 via CREB1 regulation Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-14 Lei Cao, Yan Wang, Juanni Liu, Xiaoying Bai, Xiaohong Chi
BackgroundLong non‐coding RNAs (lncRNAs) play crucial roles in cellular processes, with dysregulation implicated in various diseases, including cancers. The lncRNA TPT1‐AS1 (TPT1 Antisense RNA 1) promotes tumor progression in several cancers, including ovarian cancer (OC), but its influence on ferroptosis and interaction with other proteins remains underexplored.MethodsIn this study, we employed a
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Antiphospholipid Syndrome Nephropathy Occurs in Pregnancy: A Case Report Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-14 Chao Ji, Yakun Wang, Xiaoxiao Zhai, Guoxin Ji
ObjectiveThis paper presents an analysis of the pregnancy trajectory and therapeutic regimen documentation of a primigravida with APSN. It aims at communicating the therapeutic approach and preventive measures for APSN in pregnancy.Case PresentationThis paper reports the trajectory and therapeutic regimen documentation of a primigravida with APSN. The APSN was discovered in a primigravida woman aged
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Arthropods to Eutherians: A Historical and Contemporary Comparison of Sparse Prenatal Microbial Communities Among Animalia Species Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-14 Gwendolynn Hummel, Kjersti Aagaard
Since the advent of next‐generation sequencing, investigators worldwide have sought to discern whether a functional and biologically or clinically relevant prenatal microbiome exists. One line of research has led to the hypothesis that microbial DNA detected in utero/in ovo or prior to birth/hatching is a result of contamination and does not belong to viable and functional microbes. Many of these preliminary
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Placental Pathologic Features and Perinatal Outcomes in Pregnant Woman With Autoimmune Connective Tissue Disease Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-13 Aman Zheng, Yushuang Zheng, Donglu Li, Xinran Li, Xia Tong, Fan Wang
IntroductionWe aimed to investigate the association between perinatal outcomes and placental pathological features in pregnant women with ACTD, including systemic lupus erythematosus (SLE), antiphospholipid antibody syndrome (APS), and undifferentiated connective tissue disease (UCTD).Materials and MethodsPlacental tissue from SLE (n = 44), APS (n = 45), and UCTD (n = 45) were included, and contemporaneous
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Preeclampsia in the Context of COVID‐19: Mechanisms, Pathophysiology, and Clinical Outcomes Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-12 Guilherme M. Nobrega, Brittany R. Jones, Indira U. Mysorekar, Maria Laura Costa
The emergence of the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has led to the global COVID‐19 pandemic, significantly impacting the health of pregnant women. Obstetric populations, already vulnerable, face increased morbidity and mortality related to COVID‐19, aggravated by preexisting comorbidities. Recent studies have shed light on the potential correlation between COVID‐19 and
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Maternal Innate Immune Reprogramming After Complicated Pregnancy Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-09 Nakeisha A. Lodge‐Tulloch, Jean‐François Paré, Camille Couture, Elsa Bernier, Tiziana Cotechini, Sylvie Girard, Charles H. Graham
ProblemPreeclampsia (PE) and fetal growth restriction (FGR) are often associated with maternal inflammation and an increased risk of cardiovascular and metabolic disease in the affected mothers. The mechanism responsible for this increased risk of subsequent disease may involve reprogramming of innate immune cells, characterized by epigenetic modifications.Method of StudyCirculating monocytes from
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Characterization of Inflammation/Immune‐, Acute Phase‐, Extracellular Matrix‐, Adhesion‐, and Serine Protease‐Related Proteins in the Amniotic Fluid of Women With Early Preterm Prelabor Rupture of Membranes Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-08 Hyeon Ji Kim, Kyong‐No Lee, Kyo Hoon Park, Bo Young Choi, Iseop Cho, Min Jung Lee
ProblemTo determine whether altered concentrations of various inflammation/immune‐, acute phase‐, extracellular matrix‐, adhesion‐, and serine protease‐related proteins in the amniotic fluid (AF) are independently associated with microbial invasion of the amniotic cavity and/or intra‐amniotic inflammation (MIAC/IAI), imminent spontaneous preterm delivery (SPTD; ≤7 days), and major neonatal morbidity/mortality
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Impaired Epithelial CD200L Tolerance Signaling in Irritable Bowel Syndrome Cases With Diarrhea May Be Associated With Recurrent Miscarriages Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-08 David A. Clark, Paul Moayyedi
ProblemThere is a higher incidence of irritable bowel syndrome with miscarriages, and recurrent miscarriages of otherwise normal embryos have been linked to subnormal expression of the immune checkpoint inhibitor CD200L. We sought to determine if alterations in the expression of the CD200 immune checkpoint inhibitor occur in colonic tissue in IBS‐D patients.Method of StudyQuantitative immunohistochemical
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Effects of Maternal SARS‐CoV‐2 Infection During Pregnancy on Fetal Development Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-08-08 Jianan Li, Jingwen Yao, Zeyu Yang
BackgroundThe severe acute respiratory syndrome coronavirus (SARS‐CoV‐2) outbreak in 2019 has necessitated investigating its potential adverse effects on pregnancy outcomes and fetal development.ObjectiveThis study aimed to review the evidence on the impact of SARS‐CoV‐2 infection during pregnancy on fetal outcomes.Method of StudyLiteratures since the outbreak of COVID‐19 from PubMed and Web of Science
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Plasma Kallistatin and Progranulin as Predictive Biomarkers of Intraamniotic Inflammation, Microbial Invasion of the Amniotic Cavity, and Composite Neonatal Morbidity/Mortality in Women With Preterm Premature Rupture of Membranes Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-29 Kyo Hoon Park, Kyong‐No Lee, Iseop Cho, Min Jung Lee, Bo Young Choi, Da Eun Jeong
ProblemTo explore the clinical utility of nine inflammatory immune‐, adhesion‐, and extracellular matrix‐related mediators in the plasma for predicting intraamniotic inflammation and/or microbial invasion of the amniotic cavity (IAI/MIAC) and composite neonatal morbidity and/or mortality (CNMM) in women with preterm premature rupture of membranes (PPROM) when used alone or in combination with conventional
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Evaluating the IL‐6 Family of Cytokines Throughout Equine Gestation Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-29 Carleigh E. Fedorka, Kirsten E. Scoggin, Hossam El‐Sheikh Ali, Mats H. T. Troedsson
IntroductionThe interleukin (IL)‐6 family of cytokines is grouped by a common receptor subunit (gp130), but functions in distinct but overlapping physiological activities, including regulation of acute phase reaction and the balance between effector and regulatory T cell populations—both of which play a role in successful pregnancy maturation.MethodsHere, we aim to assess the expression profiles of
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Predicting the Outcomes of In Vitro Fertilization Using Baseline Maternal Serum Inflammatory Markers: A Retrospective Cohort Study Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-25 Sedigheh Hantoushzadeh, Marzie Poorabdoli, Mohammadamin Parsaei, Nikan Zargarzadeh, Masoumeh Masoumi, Saeedeh Eslami Khotbesara, Azadeh Tarafdari
ProblemAchieving pregnancy through in vitro fertilization (IVF) remains a challenge, with less than one‐third of women succeeding. There is a pressing need for reliable predictive tools to assess the likelihood of post‐IVF pregnancy. While some serum inflammatory biomarkers have been investigated for their predictive potential, substantial knowledge gaps persist. This study examined the utility of
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Placental Senescence and the Two‐Stage Model of Preeclampsia Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-25 Meryam Sugulle, Bendik S. Fiskå, Daniel Pitz Jacobsen, Heidi Elisabeth Fjeldstad, Anne Cathrine Staff
In this review, we summarize how an increasingly stressed and aging placenta contributes to the maternal clinical signs of preeclampsia, a potentially lethal pregnancy complication. The pathophysiology of preeclampsia has been conceptualized in the two‐stage model. Originally, highlighting the importance of poor placentation for early‐onset preeclampsia, the revised two‐stage model explains late‐onset
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Cytotoxic T Lymphocytes, Tc17 Cells, Th1 Cells, and ThGM Cells are Increased in the Blood and Ectopic Endometrium of Patients With Adenomyosis Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-23 Li Zhang, Lei Zhu, Pengfei Che, Xiaoyan Sun, Yupeng Guo, Mingjie Gao, Junjie Wang
ProblemAdenomyosis (AM) is associated with immune response and inflammation. However, the role of T cell subsets in AM development has not been thoroughly understood.Method of StudyPatients with focal or diffuse AM were recruited. Serum cytokines were quantified by enzyme‐linked immunosorbent assay (ELISA). Different T cell subsets in the blood and ectopic endometrium were determined by flow cytometry
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LPS‐Induced Mitochondrial Dysfunction Reduces Oocyte Maturation and Developmental Competence of Buffalo Embryos via ROS Mediated TLR4 Signalling Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-23 Sujata Jinagal, Ravi Dutt, Maninder Sharma, Meeti Punetha, Sheetal Saini, Swati Thakur, Suman Chaudhary, Pradeep Kumar, Prem Singh Yadav, Tirth Kumar Datta, Dharmendra Kumar
ProblemLipopolysaccharide (LPS) from gram‐negative bacteria has reportedly been associated with infectious diseases like metritis, which has a substantial adverse effect on animal reproductive performance and causes serious financial losses for the dairy sector. The current work aimed to establish the impact of LPS on in vitro oocyte maturation and subsequent in vitro developmental competence of oocytes
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The Efficacy of C‐Reactive Protein (CRP) to Albumin Ratio (CAR) and Fibrinogen to CRP Ratio (FCR) in Predicting the Latent Period of Preterm Labor Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-23 Zeynep Seyhanli, Burak Bayraktar, Betul Tokgoz Cakir, Mevlut Bucak, Gulsan Karabay, Gizem Aktemur, Ayse Yigit, Kadriye Yakut Yucel, Zehra Vural Yılmaz
ObjectiveTo investigate the role of inflammatory markers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR), c‐reactive protein (CRP) to albumin ratio (CAR), fibrinogen to albumin ratio (FAR), and fibrinogen to CRP ratio (FCR) in predicting the latency period (≤72 vs. >72 hours) before preterm birth.Materials and MethodsIn a retrospective
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Biomarker Identification for Preterm Birth Susceptibility: Vaginal Microbiome Meta‐Analysis Using Systems Biology and Machine Learning Approaches Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-21 Sudeepti Kulshrestha, Priyanka Narad, Brojen Singh, Somnath S. Pai, Pooja Vijayaraghavan, Ansh Tandon, Payal Gupta, Deepak Modi, Abhishek Sengupta
ProblemThe vaginal microbiome has a substantial role in the occurrence of preterm birth (PTB), which contributes substantially to neonatal mortality worldwide. However, current bioinformatics approaches mostly concentrate on the taxonomic classification and functional profiling of the microbiome, limiting their abilities to elucidate the complex factors that contribute to PTB.Method of studyA total
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IL‐33 Signaling Inhibition Leads to a Preeclampsia‐Like Phenotype in Pregnant Rats Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-13 Xi Wang, Corbin A. Shields, Deanna Thompson, Jie McKay, Rachel Wilson, Marcus K. Robbins, Hannah Glenn, Molly Fontenot, Jan M. Williams, Denise C. Cornelius
ProblemPreeclampsia (PE) is a hypertensive pregnancy disorder that is a leading cause of maternal and fetal morbidity and mortality characterized by maternal vascular dysfunction, oxidative stress, chronic immune activation, and excessive inflammation. No cure exists beyond delivery of the fetal–placental unit and the mechanisms driving pathophysiology are not fully understood. However, aberrant immune
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Association Between Influenza Vaccination and SARS-CoV-2 Infection Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-12 Marwan Ma'ayeh, Jessica A. de Voest, Brenna L. Hughes, William A. Grobman, George R. Saade, Tracy A. Manuck, Monica Longo, Hyagriv N. Simhan, Dwight J. Rouse, Hector Mendez-Figueroa, Cynthia Gyamfi-Bannerman, Jennifer L. Bailit, Maged M. Costantine, Harish M. Sehdev, Alan T. N. Tita, Torri D. Metz
Recent data in nonpregnant individuals suggest a protective effect of influenza vaccination against SARS-CoV-2 infection and its severity.
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Intravenous Immunoglobulins for Recurrent Chronic Histiocytic Intervillositis: A Series of Case Studies Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-08 Noémie Abisror, Meryam Cheloufi, Jonathan Cohen, Aurore Coulomb, Chloé McAvoy, Olivier Fain, Jean Luc Taupin, Vassilis Tsatsaris, Gilles Kayem, Arsène Mekinian
IntroductionChronic histiocytic intervillositis (CHI) is a rare inflammatory placental disease characterized by diffuse infiltration of monocytes into the intervillous space and is associated with adverse pregnancy outcomes. No treatment is currently validated and although in some small reports, steroids with hydroxychloroquine have been described. There are no data for other therapies in refractory
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Correlation of Anti‐Phosphatidylserine/Prothrombin and Anti‐Phosphatidylserine Antibodies with Pregnancy Outcomes Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-03 Junmiao Xiang, Yundong Pan, Ruru Bao, Zhuhua Cai
BackgroundThe objective of this study was to investigate the clinical relevance of anti‐prothrombin antibodies (aPT) and anti‐phosphatidylserine/prothrombin antibodies (aPS/PT) in relation to pregnancy outcomes and coagulation parameters, as well as immune markers.MethodsWe retrospectively analyzed 477 pregnant women with experienced at least one spontaneous miscarriage who were tested for aPT and
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Embryo Quality Conditions the Secretory Profile of Tolerogenic Dendritic Cell DC‐10 During the Peri‐Implantation Period Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-03 Soledad Gori, Laura Fernández, Elizabeth Soczewski, Ana Schafir, Lara Castagnola, Esteban Grasso, Gustavo Martínez, Claudia Pérez Leirós, Rosanna Ramhorst
ProblemThe decidualization process conditions monocytes to the immunosuppressive and tolerogenic dendritic cell (DC)‐10 profile, a DC subset with high IL‐10 production. Since the implantation process implies an embryo‐endometrium‐immune crosstalk, here we focused on the ability of embryonic soluble factors to modify decidual DC conditioning accordingly with its quality.Method of StudyHuman endometrial
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Construction of m6A‐Related Gene Prediction Model and Subtype Analysis in Non‐Obstructive Azoospermia Based on Bioinformatics Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-03 Guikang Li, Kai Che, Jie Wu, Bin Yang
PurposeNon‐obstructive azoospermia (NOA) is a severe and common cause of male infertility. Currently, the most reliable predictor of sperm retrieval success in NOA is histopathology, but preoperative testicular biopsy often increases the difficulty of sperm retrieval surgery. This study aims to explore the characteristics of N6‐methyladenosine (m6A) modification in NOA patients and investigate the
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Mechanism of Vaginal Epithelial Cell Pyroptosis Induced by the NLRP3 Inflammasome in Vulvovaginal Candidiasis Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-03 Yongmei Peng, Yanan Xu, Sainan Li, Mingkun Shao, Zijia Shen, Wenjin Qi
ProblemVulvovaginal candidiasis (VVC) is a common mucosal fungal infection, and Candida albicans is the main causative agent. The NLRP3 inflammasome plays an important role in VVC, but the underlying mechanism is unknown.Method of StudyVaginal epithelial cells were divided into three groups: control, C. albicans strain SC5314 (wild‐type, WT), and WT+ Matt Cooper Compound 950 (MCC950, a specific NLRP3
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Predictability of the Delta Neutrophil Index and Other Blood Parameters on Perinatal Outcomes in Pregnant Women With Systemic Lupus Erythematosus Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-07-03 Şükran Doğru, Fatih Akkuş, Huriye Ezveci, Fikriye Karanfil Yaman, Selman Parlak, Ülfet Sena Metin, Pelin Bahçeci, Ali Acar
ProblemThis study aimed to evaluate the predictive value of delta neutrophil index (DNI), a peripheral blood parameter, on perinatal outcomes in pregnant women with systemic lupus erythematosus (SLE).Method of StudyOne hundred eighty‐one participants, 78 pregnant women with SLE, and 103 healthy pregnant women were included in this retrospective study. Peripheral blood parameters including neutrophil‐to‐lymphocyte
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Authors’ reply: Commentary on “Intrauterine perfusion of dexamethasone improves pregnancy outcomes in recurrent reproductive failure patients with elevated uterine natural killer cells. A retrospective cohort study” Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-06-25 Feng Zhang, Zhuran Wang, Ruochun Lian, Lianghui Diao, Yuye Li, Yaya Wu, Tailang Yin, Chunyu Huang
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TIM‐3 Expression in Endometriosis Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-06-24 José Lourenço Reis, Catarina Martins, Miguel Ângelo‐Dias, Natacha Nurdine Rosa, Luís Miguel Borrego, Jorge Lima
ProblemEndometriosis is a prevalent chronic gynecological disease linked to immune dysfunction. The protein T‐cell immunoglobulin and mucin domain‐containing protein 3 (TIM‐3) plays a crucial role in immune system balance. Malfunction of TIM‐3 may result in excessive immune activation and inflammatory tissue damage. Given TIM‐3's established role in the development of cancer and autoimmune diseases
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Causal Relationship Between Circulating Immune Cells and Recurrent Spontaneous Abortion: A Bidirectional Mendelian Randomization Study Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-06-24 Hailin Yu, Xianyang Hu, Xixi Huang, Tingxuan Yin, Lu Liu, Chaoyan Yue, Meirong Du
BackgroundRecurrent spontaneous abortion (RSA) is a serious and common complication of pregnancy caused by multiple factors. The etiology remains incompletely understood, but immunologic factors play important roles. Here, we aimed to evaluate whether circulating immune cells causally impacted RSA.MethodsIn this study, we conducted a comprehensive two‐sample Mendelian randomization (MR) study to determine
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Comprehensive Analysis of Damage Associated SNPs of Luteinizing Hormone and Its Receptor: A Computational Approach Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-06-21 Richa Bhatnager, Kajal Gaba, Amita Suneja Dang
ProblemThe luteinizing hormone (LH), produced by gonadal and nongonadal cells in the anterior pituitary gland play a critical role in human sexual development and reproduction. It is required for the induction of ovulation in females and sex steroid hormone production in both males and females. It is also an important player in early pregnancy events in oviducts and in absence of LH signalling, the
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Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-06-21 Tansim Akhter, Mikael Hedeland, Jonas Bergquist, Kumari Ubhayasekera, Anders Larsson, Ludvig Byström, Merit Kullinger, Alkistis Skalkidou
ProblemPreterm birth (PTB) is a leading cause of infant mortality and morbidity. The pathogenesis of PTB is complex and involves many factors, including socioeconomy, inflammation and infection. Asymmetric dimethylarginine, ADMA and symmetric dimethylarginine, SDMA are involved in labor as inhibitors of nitric oxide, a known relaxant of the uterine smooth muscles. Arginines are scarcely studied in
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Differential proteomics of circulating extracellular vesicles of placental origin isolated from women with early‐onset preeclampsia reveal aberrant innate immune and hemostasis processes Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-05-28 Aishwarya Rao, Rambhadur Subedi, Indra Kundu, Susan Idicula‐Thomas, Uma Shinde, Vandana Bansal, Geetha Balsarkar, Niranjan Mayadeo, Dhanjit Kumar Das, Nafisa Balasinor, Taruna Madan
ProblemEarly‐onset preeclampsia (EOPE) is a severe gestational hypertensive disorder with significant feto‐maternal morbidity and mortality due to uteroplacental insufficiency. Circulating extracellular vesicles of placental origin (EV‐P) are known to be involved in the pathophysiology of EOPE and might serve as an ideal reservoir for its specific biomarkers. Therefore, we aimed to characterize and
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NANOG regulate the JAK/STAT3 pathway to promote trophoblast cell migration and epithelial‐mesenchymal transition (EMT) in hypertensive disorders of pregnancy (HDP) through protein interaction with CDK1 Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-05-26 Jing Ma, Mingchang Liu, Zhuo Chen, Shiyang Liu, Huijuan Yang, Mengjia Duan
ProblemHypertensive disorders of pregnancy (HDP) are a common pregnancy disease. NANOG and Cyclin‐dependent kinase 1 (CDK1) are essential for regulating the function of cell proliferation and apoptosis. However, the mechanism of action in HDP is yet unclear.MethodThe microarray dataset GSE6573 was downloaded from the GEO database. Emt‐related gene set was downloaded from Epithelial‐Mesenchymal Transition
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A case of amenorrhea: Caused by Oseltamivir or Influenza a virus? Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-05-26 Peng Zhou, Shixiao Li
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Seminal plasma hypersensitivity: A systematic review of clinical presentation, diagnostics, and management options Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-05-22 Kayla Schacher, Mudar Dalloul, Ozgul Muneyyirci‐Delale
IntroductionSeminal plasma hypersensitivity (SPH) is a rare and often misdiagnosed condition characterized by local and/or systemic reactions to seminal plasma proteins following exposure to semen. We aimed to summarize key symptomatology, diagnostic features, and management options for SPH.MethodsThe databases PubMed, EMBASE, Web of Science, Google Scholar, and Cochrane Review were searched with key
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The significance of Syndecan 1, a new marker for endothelial dysfunction, in cases of fetal growth retardation Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-05-19 Yüksel Oğuz, Recep Taha Ağaoğlu, Can Ozan Ulusoy, Dilara Kurt, İzzet Özgürlük, Çağanay Soysal, Zehra Yılmaz Vural, Kadriye Yakut Yücel
ProblemIn the current study we aimed to investigate Syndecan 1 (SDC1) levels in pregnant women diagnosed with fetal growth restriction (FGR) and the relationship between SDC1 levels and clinical and doppler parameters in FGR cases associated with endothelial dysfunction, angiogenesis and uteroplacental insufficiencyMethod of StudyA total of 90 pregnant women included in the study, (45 with FGR, 45
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Heme metabolism and HO‐1 in the pathogenesis and potential intervention of endometriosis Am. J. Reprod. Immunol. (IF 2.5) Pub Date : 2024-05-15 Ding‐Yu Hou, Jia‐Jing Lu, Xing Zhang, Ayitila Abudukeyoumu, Ming‐Qing Li, Xiao‐Yong Zhu, Feng Xie
Endometriosis (EM) is one of the diseases related to retrograded menstruation and hemoglobin. Heme, released from hemoglobin, is degraded by heme oxygenase‐1 (HO‐1). In EM lesions, heme metabolites regulate processes such as inflammation, redox balance, autophagy, dysmenorrhea, malignancy, and invasion, where macrophages (Mø) play a fundamental role in their interactions. Regulation occurs at molecular