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Epicardial adipose tissue thickness associated with preeclampsia and birth weight in early pregnancy Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-08-11 Jing Wang, Chunfeng Li, Wen Li, Yexiao Tao, Yong Li
Preeclampsia (PE) increases the risk of many adverse maternal and fetal outcomes. This study was to investigate the correlation between epicardial adipose tissue (EAT) thickness and PE and birth we...
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Diagnosis of preeclampsia using metabolomic biomarkers Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-07-22 Yunfan Tian, Mingwei Liu, Jin-Yu Sun, Yifeng Wang, Lianmin Chen, Wei Sun, Ling Zhou
The diagnostic criteria for preeclampsia do not accurately reflect the pathophysiological characteristics of patients with preeclampsia. Conventional biomarkers and diagnostic approaches have prove...
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The impact of hyperandrogenemia on pregnancy complications and outcomes in patients with PCOS: a systematic review and meta-analysis Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-07-14 Xiaohan Guo, Yingsha Yao, Ting Wang, Juanhong Wu, Ruoan Jiang
Polycystic ovary syndrome (PCOS) is a metabolic and reproductive disorder. Current research findings present conflicting views on the effects of different PCOS phenotypes on outcomes in pregnancy a...
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An in vitro study of coagulation evaluation in obstetric hemorrhage for pregnancy-induced hypertension with coagulation and platelet function analyzer Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-06-12 Caihong Cao, Maimaitijiang Yusupu, Yaoqi Wang, Yonghao Yu
This study aimed to establish in vitro hemodilution and resupplementation assays for obstetric hemorrhage in pregnancy-induced hypertension (PIH) and to monitor the coagulation function dynamically...
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Gene therapy in preeclampsia: the dawn of a new era Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-05-30 Fengxuan Sun, Maureen Peers de Nieuwburgh, Corinne Hubinont, Frédéric Debiève, Arthur Colson
Preeclampsia is a severe complication of pregnancy, affecting an estimated 4 million women annually. It is one of the leading causes of maternal and fetal mortality worldwide, and it has life-long ...
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Anti-hypertensive therapy for preeclampsia: a network meta-analysis and systematic review Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-03-15 Ting Wang, Ruoan Jiang, Yingsha Yao, Ting Xu, Na Li
Preeclampsia (PE) is a pregnancy disorder that represents a major cause of maternal and perinatal morbidity and mortality.This network meta-analysis was registered with PROSPERO. We searched the Pu...
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Predicting intensive care need in women with preeclampsia using machine learning – a pilot study Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-02-22 Camilla Edvinsson, Ola Björnsson, Lena Erlandsson, Stefan R. Hansson
Predicting severe preeclampsia with need for intensive care is challenging. To better predict high-risk pregnancies to prevent adverse outcomes such as eclampsia is still an unmet need worldwide. I...
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Effects of hypertensive disorders of pregnancy on the complications in very low birth weight neonates Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-02-20 Baoquan Zhang, Xiujuan Chen, Changyi Yang, Huiying Shi, Wenlong Xiu
This study was designed to investigate the effects of hypertensive disorders of pregnancy (HDP) on the complications in very low birth weight (VLBW) neonates.We retrospectively included VLBW neonat...
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Use of the USCOM® noninvasive cardiac output measurement system to predict the development of pre-eclampsia in hypertensive pregnancies Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-02-14 Jack George Mangos, Shyamalee Crocker, Macayla Flood, Jade Martyn, Lynne Roberts, Amanda Henry, Franziska Pettit
To assess the ability of the USCOM® (USCOM), using measurements of cardiac output (CO) and systemic vascular resistance (SVR), to predict the development of pre-eclampsia (PE) and severe PE in hype...
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Trimester and severity of SARS-CoV-2 infection during pregnancy and risk of hypertensive disorders in pregnancy Hypertens. Pregnancy (IF 1.5) Pub Date : 2024-01-27 Samantha E. Parker, Bhavana Annapragada, Idalis A. Chestnut, Jessica Fuchs, Annette Lee, Vishakha Sabharwal, Elisha M. Wachman, Christina D. Yarrington
SARS-CoV-2 infection during pregnancy has been linked with an increased risk of hypertensive disorders of pregnancy (HDP). The aim of this study was to examine how both trimester and severity of SA...
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Relationship between the hemodynamic profile and resistant hypertension in pregnant patients with hypertensive crisis Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-12-07 María Andrea Zambrano, Jose A. Rojas-Suarez, Evelyn E. Peña-Zarate, Javier Andres Carvajal, Laura Sofia Gutierrez-Puerto, Felipe Aguilar-Cano, Jose Santacruz-Arias, Merida Rodríguez-Lopez, María Fernanda Escobar
Reducing maternal morbidity and mortality has been a challenge for low and middle-income countries, especially in the setting of hypertensive disorders of pregnancy. Improved strategies for treatin...
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Associations between extreme temperature exposure and hypertensive disorders in pregnancy: a systematic review and meta-analysis Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-12-05 Yanxia Mao, Qian Gao, Ying Zhang, Yan Yue, Tiechao Ruan, Yi Yang, Tao Xiong
Background: Hypertensive disorders in pregnancy (HDP) are a major cause of maternal mortality and morbidity. Recent studies indicated that pregnant women are the most vulnerable populations to ambi...
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Genetic liability between COVID-19 and pre-eclampsia/eclampsia: a Mendelian randomization study Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-11-28 Yuhang Xing, Zhen Wang, Xiaohua Qi, Qunli Xu, Rui Pu
The aim of this study was to investigate the possible causal relationship between COVID-19 and the risk of pre-eclampsia/eclampsia using a Mendelian randomized (MR) design.We estimated their geneti...
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Administration of corticosteroid therapy for HELLP syndrome in pregnant women: evidences from seven randomized controlled trials Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-11-08 Wei-Jing Sun, Jing Hu, Qing Zhang, Jin-Mei Shan
HELLP syndrome, featuring hemolysis, elevated liver enzymes, and thrombocytopenia, is life-threatening disease of pregnancy that triggers comorbidities in both pregnant women and the fetus/newborn....
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Women with preeclampsia may have reduced risk of breast cancer: a meta-analysis of cohort studies with 7.8 million participants Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-10-17 Min Yao, Lijie Chen, Puchao Peng, Zhiwei Zhong
This review pooled data from the literature to examine the association between preeclampsia (PE) and subsequent risk of breast cancer in women. Cohort studies published in the databases of PubMed, ...
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Statement of Retraction: First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-10-17
Published in Hypertension in Pregnancy (Vol. 42, No. 1, 2023)
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Statement of Retraction: Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-10-17
Published in Hypertension in Pregnancy (Vol. 42, No. 1, 2023)
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Statement of Retraction: Maternal and fetal outcome in women with gestational hypertension in comparison to gestational proteinuria: A 3-year observational study Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-10-17
Published in Hypertension in Pregnancy (Vol. 42, No. 1, 2023)
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Genome-wide association study reveals HSF2, GJA1 and TRIM36 as susceptibility genes for preeclampsia: a community-based population study in Tianjin, China Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-09-21 Zhenhua Cao, Li Ma, Wei Cai, Xiulong Niu, Ning Yang, Jianmei Ni, Xiaojing Wang, Maoti Wei, Shaobo Chen, Yuming Li
Preeclampsia (PE) mainly occurs in pregnant women and is hereditary. Several genome-wide association studies (GWAS) on Caucasian samples have reported some gene loci that are associated with preecl...
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Cardiorespiratory fitness in women after severe pre-eclampsia Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-08-09 Lasse Gronningsaeter, Mette-Elise Estensen, Helge Skulstad, Eldrid Langesaeter, Elisabeth Edvardsen
ABSTRACT Aims To objectively study cardiorespiratory fitness (CRF) and physical activity (PA) and to evaluate limiting factors of exercise intolerance associated with poor CRF after severe pre-eclampsia. Methods In this single-centre, cross-sectional study, CRF was measured as peak oxygen uptake (VO2peak) during a cardiopulmonary exercise test (CPET) on a treadmill in women 7 years after severe pre-eclampsia
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First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-07-21 D. Aoulad Fares, R.E. Wiegel, A.J. Eggink, J.B.J. van Meurs, S.P. Willemsen, A.H.J. Danser, R.P.M. Steegers-Theunissen
ABSTRACT Objective To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI. Methods In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA)
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Oral nifedipine may be a preferential option for treating acute severe hypertension during pregnancy: a meta-analysis Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-07-11 Minghui Ou, Futao Zhang, Shichao Cui, Shibo Zhao, Yan Yu
ABSTRACT Aim To compare oral nifedipine and intravenous labetalol in the treatment of acute severe hypertension in pregnancy (SHP). Methods The primary outcomes were the required time to achieve target blood pressure (RTATBP), systolic blood pressure (SBP) and diastolic BP (DBP) after treatment, secondary outcomes were the number of doses (NoD) and adverse events (AEs). Results There was no difference
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Regional differences in clinical characteristics and fetal and maternal outcomes of hypertensive disorders in pregnancy in China: a retrospective study Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-07-11 Ma Rui, Huang Liping, Wang Yanmin, Zhao Tingting, Chen Shi, He Yingdong
ABSTRACT Background Hypertensive disorders in pregnancy (HDPs) are the leading causes of maternal and perinatal death worldwide, and appropriate prenatal care is beneficial toward improve pregnancy outcomes in populations at high risk of preeclampsia. Objective To describe variations in regional manifestations and outcomes of HDPs among the Chinese population to aid in the development of region-specific
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Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-07-07 P.Y.M. Leung, M Katerelos, S. Choy, N Cook, M Lee, K Paizis, A Abboud, J. A. Manning, P.F Mount, D.A Power
ABSTRACT Objective To assess changes in expression of renal epithelial sodium channel (ENaC) and NEDD4L, a ubiquitin ligase, in urinary extracellular vesicles (UEV) of pre-eclamptic women compared to normal pregnant controls. Methods Urine was collected from pre-eclamptic women (PE, n = 20) or during normal pregnancy (NP, n = 20). UEV were separated by differential ultracentrifugation. NEDD4L, α-ENaC
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Blood pressure medication use and postpartum hospital readmission among preeclampsia patients Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-06-26 Timothy Gesner, Joshua Fogel, Lennox Bryson
ABSTRACT Background Blood pressure medication is often prescribed to patients with preeclampsia. We are not aware of any study on readmission of those with preeclampsia to the hospital that considers blood pressure medication use or dose. Methods This was a retrospective study of 440 preeclampsia patients diagnosed during the antepartum, intrapartum, or immediate postpartum period prior to discharge
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The moderating role of depression in the association between hypertension during pregnancy and birth outcomes Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-06-20 Yueqi Li, Jen Jen Chang, Ruikun Zuo, Hong Xian, Darcell Scharff
ABSTRACT Objective Investigate how hypertension during pregnancy (HDP) and depression during pregnancy (DDP) independently and jointly affect infant birth outcomes. Methods This population-based, retrospective cohort study included a sample of 68,052 women who participated in PRAMS 2016–2018 survey. Poisson regression was used for adjusted relative risks (aRRs). Results Compared to women without HDP
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Hypertensive disorders of pregnancy after multifetal pregnancy reduction: a systematic review and meta-analysis Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-06-20 Petra M. van Baar, Jeske M. Bij de Weg, Eibert A. ten Hove, Linda J. Schoonmade, Lidewij van de Mheen, Eva Pajkrt, Christianne J.M. de Groot, Marjon A. de Boer
ABSTRACT Objective To systematically review the literature on hypertensive disorders of pregnancy (HDP) after multifetal pregnancy reduction (MFPR). Methods A comprehensive search in PubMed, Embase, Web of Science, and Scopus was performed. Prospective or retrospective studies reporting on MFPR from triplet or higher-order to twin compared to ongoing (i.e., non-reduced) triplets and/or twins were included
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Distinguishing preeclampsia using the falling scaled slope (FSS) --- a novel photoplethysmographic morphological parameter Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-06-19 Hang Chen, Feng Jiang, Wanlin Chen, Ying Feng, Shali Chen, Jiajun Miao, Cuicui Jiao, Xinzhong Chen
ABSTRACT Background Preeclampsia (PE) presence could lead to hemodynamic changes. Previous research suggested that morphological parameters based on photoplethysmographic pulse waves (PPGW) could help diagnose PE. Aim To investigate the performance of a novel PPGPW-based parameter, falling scaled slope (FSS), in distinguishing PE. To investigate the advantages of the machine learning algorithm over
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MiRNA-494 induces trophoblast senescence by targeting SIRT1 Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-06-05 Sha Su, Linlin Zhong, Shijin Huang, Lingjie Deng, Lihong Pang
ABSTRACT Objective Although the mechanism underlying preeclampsia (PE) has been widely explored, the mechanisms related to senescence have not yet been fully revealed. Therefore, we investigated the role of the miR-494/longevity protein Sirtuin 1 (SIRT1) axis in PE. Methods Human placental tissue was obtained from severe preeclampsia (SPE) (n = 20) and gestational age-matched normotensive pregnancies
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Prevalence of hypertensive disorders of pregnancy at or beyond 39 weeks gestational age and associated maternal complications Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-06-05 Elizabeth Fronek, Summer Martins, Stephen Contag
ABSTRACT Objective Estimate the prevalence of hypertensive disorder of pregnancy (HDP) at term, define population characteristics, and calculate adverse maternal outcomes. Methods Retrospective study. Results We included 4,702,468 pregnancies. HDP increased linearly from 4.5% (2014) to 6.0% (2018). HDP was more frequent among black (PR 1.19), obese (PR 2.31 to 3.70), with gestational (PR 1.87) or pregestational
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Long-term outcomes of patients with preeclampsia, a review of the literature Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-05-31 Alice Tassi, Alessia Sala, Ilaria Mazzera, Stefano Restaino, Giuseppe Vizzielli, Lorenza Driul
ABSTRACT Hypertensive pregnancy disorders affect up to 10% of all pregnancies and are associated with an increased future risk of heart disease, chronic hypertension, kidney dysfunction, diabetes, and thromboembolism. Although mechanisms are not yet well understood, endothelial dysfunction, pro-inflammatory and procoagulant states seem to persist in women with a history of preeclampsia many years after
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Association between ABO blood groups and preeclampsia Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-05-11 Hid Felizardo Cordero-Franco, Ana María Salinas-Martínez, Luis Ángel Garza-de Hoyos, Sofía Denisse González-Rueda, Joaquín Darío Treviño Báez, Francisco Javier Guzmán-de la Garza
ABSTRACT Objective To determine the association between the ABO blood group and preeclampsia. Methods This is a case-control study that included patients with (n = 253) and without (n = 457) preeclampsia/eclampsia in Northeastern Mexico. Data were obtained from electronic medical records. Binary multiple logistic regression analysis was used for analyzing the association between the ABO blood group
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The obesity associated FTO gene polymorphism and the risk of preeclampsia in Iranian women: A case–control study Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-05-09 Ghasem Azizi-Tabesh, Hossein Sadeghi, Arezoo Farhadi, Mohammad Foad Heidari, Aghdas Safari, Mehdi Shakouri Khomartash, Javad Behroozi, Saeid Doaei, Maryam Gholamalizadeh
ABSTRACT Background Preeclampsia (PE) is one of the leading disorders in pregnant women with maternal and fetal complications. Obesity is considered an important risk factor for the development of PE. Genetic variations in fat mass and obesity associated (FTO) gene may play a role in the development of PE. This study aimed to investigate the possible association between FTO gene rs9939609 and PE risk
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MTHFR A1298C polymorphism: a predictor of reduced risk of preeclampsia in Punjab, Pakistan Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-03-15 Sadia Mahmood, Amna Younus, Sammar Nathaniel, Hooria Younas
ABSTRACT Objectives This study aimed to investigate the genetic association between MTHFR (A1298C) SNP and preeclampsia (PE) in Punjab, Pakistan. Methods A sample of 80 pregnant women (40 healthy pregnant women and 40 with PE) was pooled for genotyping MTHFR A1298C polymorphism by using the tetra-primer amplification refractory mutation system (ARMS) PCR. The Genotypic and allelic assessments were
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Short stature in small-for-gestational-age offspring born to mothers with hypertensive disorders of pregnancy Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-03-08 Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Jota Maki, Eriko Eto, Kei Hayata, Yosuke Washio, Junko Yoshimoto, Hirokazu Tsukahara, Hisashi Masuyama
ABSTRACT Objective To investigate the incidence and risk factors of small-for-gestational age (SGA) short stature at 2 and 3 years of age in SGA offspring born to women with hypertensive disorders of pregnancy (HDP). Methods We examined 226 women with HDP whose respective SGA offspring were delivered. Results Eighty offspring (41.2%) were diagnosed with SGA short stature. The prematurity before 32 weeks
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Increased risk of early-onset preeclampsia in pregnant women with COVID-19 Hypertens. Pregnancy (IF 1.5) Pub Date : 2023-03-09 Niraj N. Mahajan, Shweta Kesarwani, Padmaja Kumbhar, Periyasamy Kuppusamy, Madhura Pophalkar, Pratiksha Thamke, Ruchi Asawa, Saumya Sharan, Smita D Mahale, Rahul K Gajbhiye
ABSTRACT Objective To estimate incidence, risk of early and late-onset preeclampsia (PE) and understand their relationship with severity of COVID-19. Methods Pregnant women with COVID-19 (n = 1929) were enrolled from 1 April 2020 to 24 February 2022. Primary outcome measure was incidence and risk of early onset PE in women with COVID-19. Results The incidence of early and late-onset PE was 11.4% and
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Effect of regional vs general anesthesia on vital functions after cesarean section: a single center experience Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-09-16 Danka Mostic Stanisic, Nevena Kalezic, Nina Rajovic, Tatjana Ilic Mostic, Jelena Cumic, Tamara Stanisavljevic, Aleksandra Beleslin, Jelena Stulic, Ivana Rudic, Nevena Divac, Natasa Milic, Radan Stojanovic
ABSTRACT Background The aim was to determine the effect of regional anesthesia (RA) on postoperative vital functions in contrast to general endotracheal anesthesia (GEA) after the cesarean section. Methods Prospective cohort study included consecutive term pregnant women delivered by cesarean section (GEA, n = 284; RA, n = 249). Results Higher levels of blood pressure and heart rate, as well as lower
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Soluble urinary somatic angiotensin converting enzyme is overexpressed in patients with preeclampsia: a potential new marker for the disease? Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-08-23 Fernando Sontag, Sonja Suvakov, Vesna D Garovic
ABSTRACT Objective The aim of this study was to identify and quantify urinary Angiotensin-Converting-Enzyme (ACE) in hypertensive disorders of pregnancy. Methods Urine samples were analyzed by Western blot. Patients were classified into: normotensive pregnancy (N); preeclampsia and superimposed preeclampsia (PE+SPE); and gestational hypertension (GH). Results Somatic ACE protein expression was higher
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Expression of Concern: Methyldopa versus labetalol or no medication for treatment of mild and moderate chronic hypertension during pregnancy: a randomized clinical trial Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-08-02
Published in Hypertension in Pregnancy (Vol. 41, No. 3-4, 2022)
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Expression of Concern: First versus second trimester mean platelet volume and uric acid for prediction of preeclampsia in women at moderate and low risk Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-08-02
Published in Hypertension in Pregnancy (Vol. 41, No. 3-4, 2022)
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Expression of Concern: Maternal and fetal outcome in women with gestational hypertension in comparison to gestational proteinuria: A 3-year observational study Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-08-02
Published in Hypertension in Pregnancy (Vol. 41, No. 3-4, 2022)
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Intraabdominal pressure as a marker for physiologic and pathologic processes in pregnancy Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-06-06 Kavita Narang, Amy L. Weaver, Ramila A. Mehta, Vesna D. Garovic, Linda M. Szymanski
ABSTRACT Increased intraabdominal pressure (IAP) can result in compression of the abdominal-pelvic venous system leading to signs and symptoms of end organ dysfunction. It has been hypothesized as a pathophysiologic process of preeclampsia. We aim to evaluate the role of IAP in normotensive vs preeclamptic, and singleton vs twin pregnancies. We hypothesized that IAP would be higher in preeclamptics
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Association between hypertensive disorders of pregnancy and risk of attention-deficit/hyperactivity disorder in the offspring: a systematic review and meta-analysis Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-05-28 Jiejing Zhao, Lihua Xia
ABSTRACT Objective We reviewed the association between hypertensive disorders of pregnancy (HDP) and the risk of attention-deficit/hyperactivity disorder (ADHD) in children. Methods We searched the databases of PubMed, Embase, ScienceDirect, CENTRAL, and Google Scholar for studies. Results Twelve studies were included. Meta-analysis demonstrated that history of HDP results in a statistically significant
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Prediction of preeclampsia based on maternal serum endoglin level in women with pregestational diabetes mellitus Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-04-27 Roman V. Kapustin, Ekaterina V. Kopteeva, Elena N. Alekseenkova, Andrey V. Korenevsky, Ilya V. Smirnov, Olga N. Arzhanova
ABSTRACT Purpose To evaluate the level of soluble endoglin (sEng) in pregnant women with pregestational diabetes mellitus (DM) and to assess its predictive value for preeclampsia development. Methods Ninety pregnant women were enrolled in the study forming five comparison groups: type 1 DM (not planned, n = 20; planned, n = 20), type 2 DM (diet, n = 15; insulin therapy, n = 20), and the control group
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Soluble endoglin versus sFlt-1/PlGF ratio: detection of preeclampsia, HELLP syndrome, and FGR in a high-risk cohort Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-04-27 A. Iannaccone, B. Reisch, L. Mavarani, M. Darkwah Oppong, R. Kimmig, P. Mach, B. Schmidt, A. Köninger, A. Gellhaus
ABSTRACT The angiogenic factors sFlt-1 and PlGF play an established role in the detection of preeclampsia (PE). Recent data suggest that sEng might contribute to the pathogenesis of PE. However, only a few studies so far have addressed its role. This monocentric cross-sectional study of high-risk pregnancies aims to compare the levels of sFlt-1/PlGF ratio and sEng depending on different placental-related
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Inflammasomes in placental explants of women with preeclampsia cultured with monosodium urate may be modulated by vitamin D Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-04-09 Priscila Rezeck Nunes, Mariana Romao-Veiga, Vanessa Rocha Ribeiro, Larissa Ragozo Cardoso de Oliveira, Igor de Carvalho Depra, Leandro Gustavo de Oliveira, Jose Carlos Peracoli, Maria Terezinha Serrao Peracoli
ABSTRACT Objectives Preeclampsia (PE) is an important syndrome of gestation characterized by placental and systemic inflammation. High plasma concentration of uric acid are frequently associated with inflammation and endothelial dysfunction and may contribute to PE pathogenesis. This study aimed to evaluate the vitamin D (VD) immunomodulatory effect on the NLRP1/NLRP3 inflammasomes in placental explants
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Different dosage regimens of nifedipine, labetalol, and hydralazine for the treatment of severe hypertension during pregnancy: a network meta-analysis of randomized controlled trials Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-03-31 Hui-Zhen Wu, Yuan Cheng, Ding Yu, Ji-Bin Li, Yun-Fa Jiang, Zhong-Ning Zhu
ABSTRACT Objectives This network meta-analysis aimed to compare the efficacy and safety of intravenous (IV) hydralazine, oral nifedipine, and IV labetalol with different dosage regimens in the treatment of severe hypertension during pregnancy. Methods A comprehensive literature search was performed on PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov for randomized controlled trials (RCTs)
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MiR-140-5p exerts a protective function in pregnancy-induced hypertension via mediating TGF-β/Smad signaling pathway Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-03-30 Ji-Yun Li, Yan Jin, Yan-Min Cao, Gui-Mei Wu
ABSTRACT Animal experiments showed that PIH rats had increased mean arterial pressure (MAP), systolic blood pressure (SBP), and diastolic blood pressure (DBP), but decreased litter size, number of viable fetuses, fetal weight, and placental weight. The higher Flt-1 and lower VEGF was observed in PIH rats with elevated TNF-α and IL-6 levels and decreased IL-10 levels. Treatment with agomiR-140-5p improved
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Long non-coding RNA PAXIP-AS1 promotes viability, invasion, and migration of HTR-8/SVneo cells through miR-210-3p/BDNF axis Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-03-22 Xuejuan Chen, Xiang Kong, Gang Niu, Fengjin Qin, Yan Duan, Fengjiao Ren
ABSTRACT Objective The aim of this research was to explore the role and potential mechanism of long non-coding RNA PAXIP-AS1 in preeclampsia. Methods To investigate the effects of PAXIP-AS1 on cell viability, migration, and invasion. The miR-210-3p-targeted relationship with lncRNA PAXIP-AS1 or BDNF was verified. Results PAXIP-AS1 was inversely correlated with miR-210-3p and BDNF was targeted by miR-210-3p
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Cardiovascular and hemodynamic consequences of recombinant placental growth factor administration in Guinea pigs Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-03-07 Adelene Y. Tan, Ken Kearney, Courtney Jenkins, S. Ananth Karumanchi, Walter Bee, Paul Kussie
ABSTRACT Placental growth factor (PlGF), a member of the vascular endothelial growth factor family of proteins regulating angiogenesis, has been shown to have acute vasodilatory effects on human resistance arteries. However, the acute hemodynamic effects of PlGF in vivo are not known. The aim of this study was to report acute cardiovascular changes induced by recombinant human PlGF administered intravenously
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Subclinical myocardial dysfunction in patients with complete recovery from peripartum cardiomyopathy: a long-term clinical strain-echocardiographic study Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-03-06 Haldun Akgoz, Ufuk Gurkan
ABSTRACT Purpose The aim of this study was to assess long-term left ventricular (LV) systolic function using 3D speckle tracking echocardiography in patients with complete LV recovery following peripartum cardiomyopathy (PPCM). Methods A total of 20 PPCM patients who exhibited LV recovery (ejection fraction ≥50%) in the follow-up period and 20 age-matched, healthy women were included in the study.
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Letter by Lu et al regarding article, “the role of aspirin dose and initiation time in the prevention of preeclampsia and corresponding complications: a meta-analysis of RCTs” Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-02-24 Zhuo Deng, Xuanqi Wang, Dan Lu
(2022). Letter by Lu et al regarding article, “the role of aspirin dose and initiation time in the prevention of preeclampsia and corresponding complications: a meta-analysis of RCTs”. Hypertension in Pregnancy: Vol. 41, No. 2, pp. 97-98.
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Preconceptual leptin levels in gestational diabetes and hypertensive pregnancy Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-02-18 Antti Peltokorpi, Lisinen Irina, Viikari Liisa, Kaaja Risto
ABSTRACT Pregnancy – induced hypertension (PIH), preeclampsia (PE), and gestational diabetes (GDM) are common adverse outcomes in pregnancy. Objective To find out whether preconceptual leptin levels differ in subsequent pregnancy between control vs. GDM and hypertensive pregnancy groups. Materials and Methods Data was from The Cardiovascular Risk in Young Finns Study and The Medical Birth Register
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MiR-125b-5p ameliorates hypoxia/reoxygenation-induced endothelial cell dysfunction and attenuates reduced uterine perfusion pressure-induced hypertension in pregnant rats via targeting BMF Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-02-16 Haoyu Zheng, Zhou Yu, Hairong Wang, Hongxue Liu, Xiaoqin Chen
ABSTRACT Background and Purpose MicroRNA-125b-5p (miR-125b-5p) is downregulated in patients with gestational hypertension signs. However, the role of miR-125b-5p in pregnancy-induced hypertension (PIH) remains unknown. Methods The human placental microvascular endothelial cells (HPMECs) have undergone hypoxia and reoxygenation (H/R) treatment to establish PIH cellular model. Rats were performed with
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IGFBP1 inhibits the invasion, migration, and apoptosis of HTR-8/SVneo trophoblast cells in preeclampsia Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-02-16 Xiujuan Li, Chenxi Li, Ye Wang, Jianxing Cai, Li Zhao, Zhiying Su, Huiming Ye
ABSTRACT Objective To investigate the effects and underlying mechanisms of IGFBP1 on the biological functions of trophoblasts in simulated preeclampsia. Methods IGFBP1 expression in placenta was determined by immunohistochemistry. HTR-8/SVneo cells were stimulated with/without IGFBP1-overexpression and hypoxia-reoxygenation, and the proliferation, invasion, migration, and apoptosis were detected by
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The association between food groups and preeclampsia: a case-control study Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-02-09 Akram Kooshki, Behnaz Sovizi, Rahil Mahmoudi, Saiedeh Ghezi, Elaheh Foroumandi
ABSTRACT Purpose The aim of current study was to investigate the correlation between preeclampsia and food groups among pregnant women. Methods This case-control study was done on pregnant women with a diagnosis of preeclampsia in Sabzevar. The control group was included non-infected postpartum women. Results Intake of vegetables (OR = 0.952, CI: 0.724–0.985, p < 0.001), fruits (OR = 0.901, CI: 0.852–0
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Letter by Lu et al. regarding article, “Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia” Hypertens. Pregnancy (IF 1.5) Pub Date : 2022-01-02 Zhuo Deng, Dan Lu
(2022). Letter by Lu et al. regarding article, “Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia”. Hypertension in Pregnancy: Vol. 41, No. 1, pp. 51-52.
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Protective effect of Fisetin on the lipopolysaccharide-induced preeclampsia-like rats Hypertens. Pregnancy (IF 1.5) Pub Date : 2021-12-22 Ying Li, Yuanyuan Liu, Jinfeng Chen, Jian Hu
ABSTRACT Objective This article is aimed to investigate the function and underlying action mechanism of Fisetin in LPS-induced PE rats. Methods LPS-induced PE-like rat model was established to explore the effects of Fisetin on PE in vivo. Results Fisetin reduced hypertension, proteinuria, TNF-α, IL-6, IL-1β, MDA, and sFlt-1/PlGF ratio, but elevated the placental, fetal weight, GSH and SOD in PE rats
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Antioxidant status in hypertensive disorders of pregnancy Hypertens. Pregnancy (IF 1.5) Pub Date : 2021-12-13 Jasmina Ivanišević, Daniela Ardalić, Gorica Banjac, Jelena Janać, Petar Cabunac, Jelena Vekić, Aleksandra Zeljković, Vesna Spasojević- Kalimanovska, Nataša Karadžov Orlić, Vesna Mandić Marković, Željko Miković, Aleksandra Stefanović
ABSTRACT Objective Pregnancy can be associated with maternal hypertension leading to possible complications in pregnancy outcome. Antioxidant status may be proned to changes during pregnancy with hypertension. The aim of our study was to estimate antioxidant status through high-risk pregnancies. Methods Seventy-nine pregnant women with high-risk for preeclampsia development were included and 46 of
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Quality improvement: patient education for management of hypertension in pregnancy Hypertens. Pregnancy (IF 1.5) Pub Date : 2021-10-26 Kriti M. Goel, Rose A. Maxwell, Morgan E. Cooley, Traci M. Rackett, Jerome L. Yaklic
ABSTRACT Objective: To assess the effectiveness of interactive education tools for hypertension in pregnancy.Two interactive education tools were introduced. Methods: Pregnant women with hypertension completed questionnaires before (Pre-I) and after)Post-I) the intervention.Providers rated satisfaction and effectiveness of the education methods. Results: The Post-I group (N=45) showed slight improvement