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Effects of 4 weeks of play in standing and walking on gross motor ability and segmental trunk control in preterm infants using a playpen: A randomized control trial Early Hum. Dev. (IF 2.2) Pub Date : 2024-09-11 Noppharath Sangkarit, Weerasak Tapanya, Chonthicha Panmatchaya, Arpapat Sangpasit, Kanitta Thatawong
To investigate the effect of computer-based early intervention with a playpen to enhance standing and walking, and to examine the relationship between changes in gross motor percentile and segmental trunk control in preterm infants nine months corrected age. Forty infants born before 37 weeks of gestation were randomly assigned to either the experimental or control group. The Alberta Infant Motor Scale
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The androgen receptor gene and criminal offending: Evidence derived from international data Early Hum. Dev. (IF 2.2) Pub Date : 2024-09-03 Lee Ellis, Anthony Hoskin, Nicholas Hasan Buker
Beginning early in fetal development, the androgen receptor (AR) gene helps regulate bodily exposure to testosterone. Most studies of individuals have found an inverse correlation between the number of CAG repeats on this gene and serious forms of physical aggression. This two-phased study was primarily undertaken to determine if a link between AR CAGn and physical aggression also exists at an ecological
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Effects of early intervention on the mental wellbeing and caregiving practices of preterm infant caregivers Early Hum. Dev. (IF 2.2) Pub Date : 2024-09-03 Eunice Eunhee Jang, Samantha Burns, Melissa Hunte, Megan Vincett, Lorraine Chiarotto, Paige T. Church
The rising incidence of preterm births worldwide presents a pressing public health challenge, affecting both infants and their preterm caregivers. Early Intervention (EI) programs aim to mitigate the negative impacts associated with preterm births on the physical, cognitive, and psychological health of both infants and their caregivers by providing personalized parental support and developmental monitoring
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The Best Start Trial: A randomised controlled trial of ultra-early parent-administered physiotherapy for infants at high risk of cerebral palsy or motor delay Early Hum. Dev. (IF 2.2) Pub Date : 2024-09-02 Barbara R. Lucas, Jenny Bowen, Catherine Morgan, Iona Novak, Nadia Badawi, Elizabeth Elliott, Genevieve Dwyer, Venkatesha Venkatesha, Lisa A. Harvey
It is unknown whether ultra-early physiotherapy commenced during neonatal intensive care unit admission is of value for optimising developmental outcomes in preterm/term infants at high-risk of cerebral palsy or motor-delay. To determine whether ultra-early parent-administered physiotherapy to preterm/term high- risk infants commenced at earliest from 34-weeks post menstrual age, improves motor outcomes
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A longitudinal study of breastmilk feeding duration, EEG power and early academic skills Early Hum. Dev. (IF 2.2) Pub Date : 2024-08-30 Syeda Fabeha Husain, Shuping Lim, Wei Wei Pang, Yi Ying Ong, Doris Fok, Anne Rifkin-Graboi, Mary F.-F. Chong, Yap Seng Chong, Mei Chien Chua, L. Mary Daniel, Mary E. Wlodek, Evelyn C. Law
The cognitive benefits of breastfeeding are widely recognized; however, its effects on brain development and later academic skills require further examination. This study aimed to examine the longitudinal relations between breastmilk feeding, neurophysiological changes, and early academic skills. In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort, breastmilk feeding practices
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Insights into neurosonographic indicators for prenatal diagnosis of fetal neurological anomalies and cortical development: A systematic review of the literature Early Hum. Dev. (IF 2.2) Pub Date : 2024-08-26 Carmen Vargas-Rodríguez, Angel Chimenea, Guillermo Antiñolo, Lutgardo García-Díaz
Congenital defects of the central nervous system are the second cause of disability in childhood, representing up to 20 % of structural malformations diagnosed prenatally. The accurate prenatal diagnosis of fetal neurological anomalies and the assessment of cortical development are critical for early intervention and improved long-term outcomes. Neurosonography plays a vital role in this process, providing
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Maternal chorioamnionitis and the risk for necrotizing enterocolitis in the United States: A national cohort study Early Hum. Dev. (IF 2.2) Pub Date : 2024-08-22 Mohsen A.A. Farghaly, Sarah Alzayyat, Daliah Kassim, Sherin A. Taha, Hany Aly, Mohamed A. Mohamed
Necrotizing enterocolitis (NEC) is a major cause for morbidity and mortality among newborn infants. Chorioamnionitis is a perinatal complication that is associated with preterm delivery. Few reports have studied chorioamnionitis as a possible risk factor for NEC. Further investigation is needed to fully understand this association. To examine the association of chorioamnionitis with NEC in newborn
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Prolonged oligohydramnios and the adverse composite outcome of death or severe neurodevelopmental impairment at 3 years of age in infants born at 22–29 gestational weeks Early Hum. Dev. (IF 2.2) Pub Date : 2024-08-15 Mitsuhiro Haga, Eri Nishimura, Ayumi Oshima, Naoyuki Miyahara, Shuntaro Oka, Yukiko Motojima, Kana Saito, Kanako Itoh, Masayo Kanai, Kazuhiko Kabe, Sumiko Era, Shinichiro Yabe, Akihiko Kikuchi, Fumihiko Namba
To investigate the association between prolonged oligohydramnios and a composite outcome of death or severe neurodevelopmental impairment (NDI) at 3 years of age. This single-center retrospective cohort study enrolled infants born at 22–29 weeks of gestational age without major congenital anomalies. The patients were classified into three groups depending on the existence and duration of oligohydramnios:
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Direct breastfeeding: Predictive factors and possible effects on neurodevelopment in very preterm infants Early Hum. Dev. (IF 2.2) Pub Date : 2024-08-14 Carlo Dani, Caterina Coviello, Martina Ciarcià, Monica Fusco, Clara Lunardi, Giulia Remaschi, Davide Sarcina, Giovanni Sassudelli, Simone Pratesi, Silvia Perugi, PROBREAST Study Group
the importance of sucking milk directly at the mother's breast is often underestimated and many aspects of direct breastfeeding of very preterm infants are not investigated. The primary endpoint of the study was to identify maternal and infant clinical predictors of direct breastfeeding in a cohort of infants born at <32 weeks of gestation or weighing <1500 g. The secondary endpoint was to evaluate
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Predictive validity of the Standardized Infant NeuroDevelopmental Assessment (SINDA) to identify 4–5 year-old children at risk of developmental delay in a low-risk sample Early Hum. Dev. (IF 2.2) Pub Date : 2024-08-05 Selena J. Rosinda, Pieter J. Hoekstra, Mijna Hadders-Algra, Annelies de Bildt, Kirsten R. Heineman
Early detection of developmental problems is important as it allows for early intervention. Previous studies, in high-risk infants, found high predictive values of atypical scores on the Standardized Infant NeuroDevelopmental Assessment (SINDA) for later neurodevelopmental disorders (i.e., cerebral palsy, intellectual disability). The present study explored SINDA's predictive values to identify risk
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High threshold of total developmental quotient at 3 years for follow-up in extremely preterm infants Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-31 Takashi Maeda, Yoshihiro Tanahashi, Hideyuki Asada, Hiroyuki Kidokoro, Yoshiyuki Takahashi, Yoshiaki Sato
To investigate the relationship between the developmental quotient (DQ) at age 3 years and the need for educational support at school age in extremely preterm infants. A total of 176 infants with a gestational age of <28 weeks were analyzed. The total DQ and subscales were evaluated using the Kyoto Scale of Psychological Development (KSPD) test. Neurodevelopment at age 3 years was stratified using
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Circadian rhythm development in preterm infants. The role of postnatal versus postmenstrual age Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-27 R.B. Govindan, Nickie N. Andescavage, Sudeepta Basu, Jonathan Murnick, Julius Ngwa, Jeffrey T. Galla, Kushal Kapse, Catherine Limperopoulos, Adre du Plessis
Circadian rhythm maturation may be disturbed in premature infants undergoing neonatal intensive care. We used continuous heart rate recordings across the entire neonatal intensive care period to study circadian rhythm development in preterm infants and to evaluate the roles of postmenstrual (PMA) versus postnatal age (PNA). The circadian rhythm was calculated using a cosine fit of heart rate. The circadian
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The relationship between digit ratio (2D:4D) and intelligence levels in specific learning disorders Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-27 Pınar AYDOĞAN AVŞAR, Tayfun KARA, Orhan KOCAMAN, Merve AKKUŞ
Higher prenatal testosterone exposure regulates brain development and affects learning and intelligence directly. The digit ratio (2D:4D) is regarded as an indicator of prenatal testosterone exposure. This study aims to investigate the 2D:4D ratios and intelligence levels in individuals with specific learning disorders (SLD) and compare the ratios with healthy subjects. The study included a total of
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Value of near-infrared spectroscopy in evaluating the risk of neonatal necrotizing enterocolitis: A systematic review and meta-analysis Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-23 Yan Gan, Junjie Ying, Xia Qiu, Siyi You, Ting Zhang, Tiechao Ruan, Ruixi Zhou, Yanxiu Ye, Yan Yue, Li Zhang, Dezhi Mu
Recently, near-infrared spectroscopy (NIRS) has been proposed for diagnosing patients with neonatal necrotizing enterocolitis (NEC). However, a consensus on the credibility of NIRS in evaluating NEC risk has not been reached. This meta-analysis aimed to evaluate the relationship between NEC and splanchnic regional tissue oxygen saturation (SrSO) and cerebral regional tissue oxygen saturation (CrSO)
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Exploring the association between haematological markers of iron and general movements in 4-month-old infants exposed to anaemia in-utero Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-20 Kiran P. Nadgauda, Deepa C. Metgud, Roopa M. Bellad, Deepthy M. Sadanandan, Arend F. Bos, Michael K. Georgieff
Iron is a vital micronutrient for brain development, influencing myelination, neurotransmitter balance, and the maturation of specific brain cells. Hence iron insufficiency in the foetal, neonatal and infancy period has the potential to influence the neuromotor development. We aimed to describe haematological markers of iron at 4 months of age in infants exposed to prenatal anaemia and explore the
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Trait mindfulness during pregnancy and maternal-infant bonding: Longitudinal associations with infant temperament and social-emotional development Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-18 Noor de Waal, Paul Lodder, Ivan Nyklíček, Lianne P. Hulsbosch, Marion I. van den Heuvel, Katleen van der Gucht, Elien de Caluwé, Victor J.M. Pop, Myrthe G.B.M. Boekhorst
Maternal love and caregiving are pillars for optimal child development and may affect infant outcomes from pregnancy onwards. The present study aimed to examine whether maternal trait mindfulness during pregnancy and pre- and postnatal maternal-infant bonding were associated with maternal perceptions of infant temperament and social-emotional development. In total, 408 Dutch women ( = 31.33, = 3.59)
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Placenta histology related to flow and oxygenation in fetal congenital heart disease Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-18 Maartje C. Snoep, Maaike Nijman, Marco C. DeRuiter, Mireille N. Bekker, Moska Aliasi, Johannes M.P.J. Breur, Arend D.J. ten Harkel, Manon J.N.L. Benders, Lotte E. van der Meeren, Monique C. Haak
Fetuses with congenital heart defects (CHD) show delayed neurodevelopment, fetal growth restriction (FGR) and placenta related complications. The neurodevelopmental delay may be, partly, attributed to placental factors. As both placental development and fetal aortic flow/oxygenation influence neurodevelopment, placentas were compared within fetal CHD groups based on aortic oxygenation and flow, aiming
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Prolonged COVID-19 related effects on early language development: A longitudinal study Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-17 Jovana Pejovic, Cátia Severino, Marina Vigário, Sónia Frota
There is growing evidence that COVID-19 brought changes that immediately affected early language development. Little is known for how long these COVID-19 related changes shaped development. The current study systematically and longitudinally addressed this issue, following up children's language development throughout the first 2.5 years. The present study follows up on the sample from Frota et al
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Parents-reported nutrition and feeding difficulties in infants with congenital diaphragmatic hernia after hospital discharge Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-14 Judith Leyens, Bartolomeo Bo, Andreas Heydweiller, Thomas Schaible, Michael Boettcher, Lukas Schroeder, Andreas Mueller, Florian Kipfmueller
Congenital diaphragmatic hernia (CDH) affects 1 in 3000–5000 newborns. In survivors, long-term complications include gastroesophageal reflux (GER), feeding difficulties, and failure to thrive. Data from the parents' perspective remain scarce. This study aims to report the prevalence and impact of feeding difficulties on CDH families after discharge. National web-based survey amongst families with CDH
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Association of second and fourth digit (2D:4D) ratios with metabolic syndrome and cardiovascular disease risk Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-11 Çağla ÖZDEMİR, Adem DURMAZ
The study aimed to investigate the association of second and fourth-digit (2D:4D) ratios with metabolic syndrome (MS) and cardiovascular disease risk (CVR). This case-control study was conducted between February and March 2024 with 200 participants (100 patients +100 controls). Biochemical parameters (glucose, total cholesterol, HDL, LDL, triglycerides, haemogram, HbA1C) were recorded. All participants
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Neonatal therapeutic hypothermia in a regional swedish cohort: Adherence to guidelines, transport and outcomes Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-11 Karla Gonzalez Tamez, Andreas Ohlin, Sverre Wikström, Andreas Odlind, Linus Olson, Lena Hellström-Westas, Johan Ågren
Swedish guidelines for therapeutic hypothermia (TH) after perinatal asphyxia were established in 2007, following several randomised studies that demonstrated improved outcomes. We assessed the implementation of hypothermia treatment in a mid-Swedish region with a sizeable proportion of outborn infants. A population-based TH cohort from 2007 to 2015 was scrutinised for adherence to national guidelines
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Factors influencing on gross motor skills in infants: Implications for walking development Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-10 Noppharath Sangkarit, Weerasak Tapanya
This longitudinal study aimed to explore the impact of containers on gross motor percentile from 8 to 13 months corrected age during the walking development in moderate to late preterm infants. Sixty preterm infants were enrolled in this study, and their monthly assessment the gross motor percentile using the Alberta Infant Motor Scale. Monthly parent interviews focused on collecting information about
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Safety of different cord clamping strategies in the early postnatal period Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-10 Akan Yaman, Kamil Sharifov, Asli Memisoglu, Ibrahim Kandemir, Baran Cengiz Arcagok, Hulya Selva Bilgen, Sibel Sakarya, Eren Ozek
This study aimed to evaluate the effect of ICC (cord clamping within the first 15 s), DCC (delayed cord clamping at 60 s), and cut-UCM (cut-umbilical cord milking, cord clamping within the first 15 s) groups on oxygen saturation (SpO2), heart rate (HR), and perfusion index (PI) up to 10 min after birth in newborn infants. We conducted this randomized clinical trial in the delivery unit of a University
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Detecting month and year of birth effects on reproduction and marriage patterns in two long-term data sets Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-05 Martin Fieder, Susanne Huber
This study examines the effects of birth month on reproduction and mating behavior using historical and contemporary census data from 1820 to 1970. The research examines the effect of birth month on the number of children for women and their male spouses, finding a monthly cycle for both men and women. In addition, the study examines whether birth month influences whether a person has ever been married
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Egg donation and gestational surrogacy: Pregnancy is riskier with an unrelated embryo Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-02 Dakota E. McCoy, David Haig, Jennifer Kotler
Modern medicine has revolutionized family planning. Remarkably, women can carry to term embryos with whom they share no genetic connection, a feat made possible through egg donation and/or gestational surrogacy. Our reproductive systems evolved to accommodate embryos that are 50% related to the carrier, not 0% related. Here, we apply evolutionary theory to explain how and why pregnancy is riskier with
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Early developmental masculinization among boys: More prenatal testosterone action (assessed via 2D:4D) renders their faces perceived as masculine but not pretty or cute Early Hum. Dev. (IF 2.2) Pub Date : 2024-07-02 Katrin Schaefer, Amalie Seidl-Berger, Sonja Windhager
The ‘organizational-activational hypothesis’ posits that the fetal environment has a lasting impact on offspring physical, cognitive, and behavioral phenotype. An established biomarker for human prenatal testosterone exposure is the second-to-fourth digit ratio (2D:4D). While related facial characteristics and their social perceptions have been investigated in young adults, studies focusing on younger
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Corrigendum to “Relationship of passive hypothermia during transport with the incidence of early multiorgan compromise in newborns with perinatal asphyxia” [Early Human Development 187 (2023) 105902] Early Hum. Dev. (IF 2.2) Pub Date : 2024-06-28 Gloria Troncoso, Sergio Agudelo-Pérez, Nicole Thorin Maldonado, Mateo Perdigón Becerra
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Sensitivity and specificity of the Neonatal Visual Assessment to predict motor and cognitive outcomes in infants born very preterm Early Hum. Dev. (IF 2.2) Pub Date : 2024-06-24 Jessica W. Blazek, Paul B. Colditz, Andrea Guzzetta, Robert S. Ware, Mark D. Chatfield, Judith L. Hough, Roslyn N. Boyd, Joanne M. George
Very preterm infants are at increased risk of neurodevelopmental impairments. The Neonatal Visual Assessment (NVA) assesses visual function and outcomes and has been used to assess early neurodevelopmental outcomes. This study aimed to compare NVA results of very preterm and term-born infants and to calculate the sensitivity and specificity of the NVA at term equivalent age (TEA) and three months corrected
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Hybrid developmental follow-up for preterm infants in Brazil: A feasibility study Early Hum. Dev. (IF 2.2) Pub Date : 2024-06-20 Isabella Saraiva Christovão, Lara de Almeida Rodrigues, Ana Carolina Cabral de Paula Machado, Ana Flávia de Souza Pascoal, Déborah Ebert Fontes, Karoline Tury de Mendonça, Lívia de Castro Magalhães, Ana Cristina Resende Camargos
The low attendance of families in child developmental follow-up programs for at-risk preterm children is a challenge in Brazil. This study evaluates the feasibility of implementing a developmental follow-up program for Brazilian preterm infants in a hybrid format. This is an observational, prospective cohort study, involving preterm infants. Longitudinal developmental test results, the participation
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First trimester maternal sex steroids and the digit ratios of mothers and children Early Hum. Dev. (IF 2.2) Pub Date : 2024-06-15 Anna Kasielska-Trojan, John T. Manning, Marek Kałuża, Ewa Głowacka, Bogusław Antoszewski
It is thought that digit ratios (2D:4D) are a correlate of 1st trimester maternal and foetal sex steroids. Here we consider the relationship of 2D:4D to the former. Digit lengths were directly measured with a calliper at infant age 13 months. Measures of T and E were obtained from mother's blood at 6–8 weeks, 10–11 weeks and 1st trimester means were calculated. There were 69 mother-infant pairs (33
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Interventions and their efficacy in supporting language development among preterm children aged 0-3 years – A systematic review Early Hum. Dev. (IF 2.2) Pub Date : 2024-06-09 Anna Markkula, Riikka Pyhälä-Neuvonen, Suvi Stolt
Preterm children have a higher risk for linguistic delays than full-term infants but are rarely provided with language intervention at an early age. Knowledge on early language interventions targeted to preterm children is scarce, and efficacy of the interventions is rarely reported. This systematic review aims to identify interventions for preterm children aged 0–3 years with at least one language
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Investigating the effects of prenatal testosterone exposure (via 2D:4D) and socio-relational factors on 3–6-year-old preschoolers' prosocial choices Early Hum. Dev. (IF 2.2) Pub Date : 2024-06-06 Lisa Horn, Sonja Windhager, Nina Juricka, Thomas Bugnyar, Jorg J.M. Massen, Gabriela Markova
Prosocial behavior such as helping and sharing develops early in childhood. Yet very few studies have investigated physiological and relational factors shaping prosociality among children. Here, we systematically examined the role of prenatal androgen exposure alongside prestige, dominance, and friendship in 3–6-year-old preschoolers' prosocial sharing with familiar peers. We tested a sample of 65
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Motor performance of Indian preterm infants as compared to the US population on the Test of Infant Motor Performance (TIMP) Early Hum. Dev. (IF 2.2) Pub Date : 2024-06-04 Diana Rodrigues, Kirti Joshi, Sayli Rajadhyaksha, Ramesh V. Debur
The study aimed at scoring Indian preterm infants at three months corrected age on the TIMP and then comparing the scores to the United States age-based population scores. After obtaining Ethical clearance, participants meeting the inclusion criteria of 53 infants whose parents consented were screened and recruited ( = 47) at a tertiary care hospital. The TIMP was then administered at three months
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Correlation of fetal lung area with MRI derived pulmonary volume Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-24 Carla L. Avena-Zampieri, Theodore Dassios, Anna Milan, Rui Santos, Vanessa Kyriakopoulou, Daniel Cromb, Megan Hall, Alexia Egloff, Matthew McGovern, Alena Uus, Jana Hutter, Kelly Payette, Mary Rutherford, Anne Greenough, Lisa Story
Neonatal chest-Xray (CXR)s are commonly performed as a first line investigation for the evaluation of respiratory complications. Although lung area derived from CXRs correlates well with functional assessments of the neonatal lung, it is not currently utilised in clinical practice, partly due to the lack of reference ranges for CXR-derived lung area in healthy neonates. Advanced MR techniques now enable
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No differences were observed in the prevention of necrotizing enterocolitis and late–onset sepsis among preterm infants who received either single–species or multi–species probiotics Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-22 Peter Korček, Zbyněk Straňák
Probiotic prophylaxis has been suggested to reduce the incidence of necrotizing enterocolitis (NEC) and late–onset sepsis (LOS) in very preterm newborns. However, choosing the optimal probiotic is difficult due to variations in strain–specific effects and interactions facilitated by the use of combination species. To compare clinical outcomes of very preterm infants receiving multi or single–species
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Neurobehavioral outcomes of infants exposed to buprenorphine-naloxone compared with naltrexone during pregnancy Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-21 Saaz Mantri, An-Chiao Cheng, Kelley Saia, Hira Shrestha, Rachel Amgott, Jonathan Bressler, Martha M. Werler, Ginny Carter, Hendree E. Jones, Elisha M. Wachman
Naltrexone is a medication used to treat both opioid and alcohol use disorder with limited experience in pregnant individuals, particularly in comparison to more commonly utilized treatments such as buprenorphine-naloxone. The long-term outcomes of infants exposed to naltrexone has not been previously examined. To compare the neurobehavioral outcomes of naltrexone versus buprenorphine-naloxone exposed
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The role of delta neutrophil index in early prediction of retinopathy of prematurity Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-21 Dilek Ulubas Isik, Istemi Han Celik, Fatih Isleyen, Fatma Pinar Tabanli, Esay Kiran Yenice
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Necrotizing enterocolitis in monochorionic twins: Insights from an identical twin model Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-21 Nour Rebai, Enrico Lopriore, Vincent Bekker, Femke Slaghekke, Michiel H.D. Schoenaker, Sophie G. Groene
Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality in preterm neonates, yet its pathophysiology remains unclear. The aim of this study is to evaluate risk factors for NEC using an identical twin model. In this case-control study, all monochorionic twin pairs born in our center in 2002–2020 were retrospectively reviewed for NEC. Potential risk factors for NEC were studied
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The use of two or more courses of low-dose systemic dexamethasone to extubate ventilator-dependent preterm neonates may be associated with a higher prevalence of cerebral palsy at two years of corrected age Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-20 Gustavo Rocha, Rita Calejo, Vanessa Arnet, Filipa Flôr de Lima, Gonçalo Cassiano, Isabel Diogo, Joana Mesquita, Gabriela Mimoso, Elisa Proença, Carmen Carvalho, Constança Gouvêa Pinto, Anabela Salazar, Marta Aguiar, Albina Silva, Almerinda Barroso, Conceição Quintas
Our objective was to determine whether the use of two or more courses of low-dose systemic dexamethasone for extubation of ventilator-dependent preterm infants after the first week of life, as proposed in the DART study, is associated with greater neurodevelopmental harm at two years of corrected age, compared to a single course. Retrospective review at seven level III neonatal intensive care units
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Reflections about being born extremely preterm in children and adolescents: A qualitative descriptive study Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-19 Anniina Väliaho, Liisa Lehtonen, Anna Axelin, Riikka Korja
The survival of the smallest and most immature preterm infants, born at 23–24 weeks of gestation, has improved significantly. While there is a substantial amount of research on the neurocognitive and social outcomes of extremely premature birth, little is known about the survivors' subjective experience of being born preterm and its effect on later life. The purpose was to study the subjective experiences
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Corrigendum to “Heart function by M-mode and tissue Doppler in the early neonatal period in neonates with fetal growth restriction”, [Early Hum. Dev. 183 (2023) 105809] Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-18 Eirik Nestaas, Lisa Bjarkø, Torvid Kiserud, Guttorm Haugen, Drude Fugelseth
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Functional lateralization in social-emotional processing: The influence of sexual orientation and gender identity on cradling preferences Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-18 Gianluca Malatesta, Daniele Marzoli, Chiara Lucafò, Anita D'Anselmo, Teresiana Azzilonna, Giulia Prete, Luca Tommasi
The left-cradling bias (i.e., the motor asymmetry for cradling infants on the left side) has often been associated to the right-hemispheric social-emotional specialization, and it has often been reported to be stronger in females than in males. In this study we explored the effects of sexual orientation and gender identity on this lateral bias by means of a web-based investigation in a sample of adults
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Neonatal neurobehavior associated with developmental changes from age 2 to 3 in very preterm infants Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-14 Alexandrea L. Craft, Marie Camerota, Cynthia Loncar, Brian S. Carter, Jennifer Check, Jennifer B. Helderman, Julie A. Hofheimer, Elisabeth C. McGowan, Charles R. Neal, T. Michael O'Shea, Steven L. Pastyrnak, Lynne M. Smith, Lynne M. Dansereau, Sheri A. DellaGrotta, Carmen Marsit, Barry M. Lester
Understand how high-risk infants' development changes over time. Examine whether NICU Network Neurobehavioral Scale (NNNS) profiles are associated with decrements in developmental outcomes between ages 2 and 3 years in infants born very preterm. The Neonatal Outcomes for Very preterm Infants (NOVI) cohort is a multisite prospective study of 704 preterm infants born <30 weeks' gestation across nine
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Effect of a lifestyle intervention among pregnant women with overweight on neonatal adiposity: A randomized controlled clinical trial Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-12 Naiara Franco Baroni, Mariana Rinaldi Carvalho, Izabela da Silva Santos, Ana Vitória Lanzoni Chaves, Daniela Elias Goulart de Andrade Miranda, Lívia Castro Crivellenti, Daniela Saes Sartorelli
The excess neonatal adiposity is considered a risk factor for the development of childhood obesity and the birth weight is a marker of health throughout life. To evaluate the effect of a lifestyle intervention conducted among pregnant women with overweight on neonatal adiposity and birth weight. A total of 350 pregnant women were recruited and randomly allocated into the control (CG) and intervention
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Associations between 2D:4D from direct and radiographic measurements with handgrip strength in young adult Tuvans Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-08 Marina Butovskaya, Yulia Adam, Valery Batsevich, Todd K. Shackelford, Bernhard Fink
Digit ratio (2D:4D) – the relative lengths of the index and ring finger – is sexually dimorphic (male < female), possibly because of the sex-differentiated impact of prenatal androgenization on fetal development in the 1st trimester. The sex difference remains stable with age and has been reported in children, adolescents, and adults from industrialized and non-industrialized societies. Handgrip strength
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Association between decreased cord blood inter-alpha inhibitor levels and neonatal encephalopathy at birth Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-07 Lynn Bitar, Barbara S. Stonestreet, Yow-Pin Lim, Joseph Qiu, Xiaodi Chen, Imran N. Mir, Lina F. Chalak
Inter-alpha inhibitor proteins (IAIPs) are structurally related proteins found in the systemic circulation with immunomodulatory anti-inflammatory properties. Reduced levels are found in inflammatory related conditions including sepsis and necrotizing enterocolitis, and in neonatal rodents after exposure to hypoxia ischemia. In the current study, cord blood IAIP levels were measured in neonates with
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Commentary on Segal (2024) “Assortative parenting and assortative cross-parenting: New views of parental preference for selected children” Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-04 Glenn Weisfeld PhD
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Commentary: Assortative parenting and assortative cross-parenting: New views of parental preference for selected children Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-03 Hila Segal
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Humanity's evolved nest and its relation to cardiac vagal regulation in the first years of life Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-03 Mary S. Tarsha, Darcia Narvaez
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Evaluating the relationship between aEEG findings and two-year prognosis in neonates with severe hyperbilirubinemia Early Hum. Dev. (IF 2.2) Pub Date : 2024-05-03 Hassan Boskabadi, Susan Hashemi Sadr, Azadeh Darabi
Identifying factors that can better predict the prognosis of neonates with hyperbilirubinemia is important. In this study, we aimed to evaluate the relationship between electroencephalography (EEG) findings and two-year prognosis in neonates with severe hyperbilirubinemia. In a cohort prospective study, we studied neonates with a total serum bilirubin level of higher than 18 mg/dL, who were admitted
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Neurocognitive outcomes in moderately preterm born adolescents Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-26 A.E. den Heijer, A.S.N. Jansen, M. van Kersbergen, N.H. van Dokkum, S.A. Reijneveld, J.M. Spikman, M.L.A. de Kroon, A.F. Bos
Early preterm (EP) born children are at risk of neurocognitive impairments persisting into adulthood. Less is known about moderately to late (MLP) preterm born children, especially after early childhood. The aim of this study was to assess neurocognitive functioning of MLP adolescents regarding intelligence, executive and attentional functioning, compared with EP and full-term (FT) adolescents. This
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Accuracy and repeatability of fetal facial measurements in 3D ultrasound: A longitudinal study Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-26 Nerea González-Aranceta, Antonia Alomar, Ricardo Rubio, Silvia Maya-Enero, Antonio Payá, Gemma Piella, Federico Sukno
Fetal face measurements in prenatal ultrasound can aid in identifying craniofacial abnormalities in the developing fetus. However, the accuracy and reliability of ultrasound measurements can be affected by factors such as fetal position, image quality, and the sonographer's expertise. This study assesses the accuracy and reliability of fetal facial measurements in prenatal ultrasound. Additionally
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Impact of neonatal pain and opiate administration in animal models: A meta-analysis concerning pain threshold Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-26 Philipp Steinbauer, Tamara Lisy, Francisco J. Monje, Eva Chwala, Brigitte Wildner, Hannah Schned, Philipp Deindl, Angelika Berger, Vito Giordano, Monika Olischar
Neonatal intensive care treatment, including frequently performed painful procedures and administration of analgesic drugs, can have different effects on the neurodevelopment. This systematic review and meta-analysis aimed to investigate the influence of pain, opiate administration, and pre-emptive opiate administration on pain threshold in animal studies in rodents, which had a brain development corresponding
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Inter-rater reliability and agreement of the General Movement Assessment and Motor Optimality Score-Revised in a large population-based sample Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-25 Caroline Alexander, Natasha Amery, Alison Salt, Catherine Morgan, Alicia Spittle, Robert S. Ware, Catherine Elliott, Jane Valentine
Prechtl's General Movement Assessment (GMA) at fidgety age (3–5 months) is a widely used tool for early detection of cerebral palsy. Further to GMA classification, detailed assessment of movement patterns at fidgety age is conducted with the Motor Optimality Score-Revised (MOS-R). Inter-rater reliability and agreement are properties that inform test application and interpretation in clinical and research
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Infant neurodevelopment during the COVID-19 pandemic: Associations with maternal pandemic-related experiences, parenting stress, and self-efficacy Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-25 Qingyu Jiang, Natalie Feldman, Amanda Koire, Candice Ma, Leena Mittal, Hung-Chu Lin, Carmina Erdei, Joshua L. Roffman, Cindy H. Liu
Although pandemic-related experiences have been linked to the psychological well-being of mothers, the effects of the COVID-19 pandemic on infant neurodevelopmental outcomes have not been sufficiently studied. To assess whether maternal COVID-19-related experiences (i.e., COVID-19-related health, risk, resource worries, and feelings of grief), parenting stress, and maternal self-efficacy are associated
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The impact of Toxocara-seropositivity on attention and motor skills in children with attention-deficit hyperactivity disorder Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-22 Mustafa Tolga Tunagur, Hatice Aksu, Evren Tileklioğlu, Hatice Ertabaklar
The study aims to compare neurological soft signs and executive functions between -seropositive and seronegative groups in children with attention-deficit/hyperactivity disorder. The study included 60 boys with ADHD, aged 7–12. After blood samples were taken, the Stroop Color Word Test and Judgment of Line Orientation test (JLOT) were implemented to measure executive functions. Neurological soft signs
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Impact of discharge criteria on the length of stay in preterm infants: A retrospective study in Japan and Finland Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-21 Ryo Itoshima, Venla Ojasalo, Liisa Lehtonen
To shorten the hospital stay in preterm infants, it is important to understand the factors extending the length of stay. To understand how different discharge criteria affect the length of stay in preterm infants. A retrospective comparison study. Preterm infants born at 28 to 31 gestational weeks in 2020–2021 in a Level IV NICU in Japan ( = 22) and a Level III NICU in Finland ( = 49). We compared
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Predictability of the neurodevelopmental assessment based on the Kyoto Scale of Psychological Development 2001 at 18–24 months of corrected age and 3 years of age in identifying cognitive impairment at 6 years of age in very preterm infants: A retrospective study at a Japanese tertiary center Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-20 Mitsuhiro Haga, Masayo Kanai, Yukiko Motojima, Kana Saito, Kanako Itoh, Takami Saito, Akio Ishiguro, Eiko Takada, Tetsuya Kunikata, Hisanori Sobajima, Fumihiko Namba, Kazuhiko Kabe
It is unknown how accurately the current Japanese classification system for neurodevelopmental delay based on the assessment with the Kyoto Scale of Psychological Development (KSPD) at toddlerhood and pre-school periods predicts cognitive impairment at school age. This single-center retrospective cohort study enrolled infants born at 22–29 weeks of gestational age. At 18–24 months of corrected age
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Characteristics and special challenges of neonatal emergency transports Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-19 S. Schumacher, B. Mitzlaff, C. Mohrmann, K.M. Fiedler, A. Heep, F. Beske, F. Hoffmann, M. Lange
As a rule, newborns do not require special medical care. If unexpected complications occur peripartum or postpartum, support from and transport to specialised neonatal hospitals might be needed. In a retrospective study, all transport protocols of a supraregional paediatric‑neonatological maximum care hospital in northwestern Germany from 01.10.2018 through 30.09.2021 were analysed. The particular
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The effect of music played to new birth mothers on postpartum blues: A randomized controlled trial Early Hum. Dev. (IF 2.2) Pub Date : 2024-04-17 Burcu KÜÇÜKKAYA, Işıl CAN, Gamze GÜLER
Postpartum blues/postpartum maternal blues is a psychological disorder experienced by mothers with symptoms of postpartum sadness, easy crying, easy anxiety, sensitivity, indecisiveness. The study aimed to examine the effect of music played on newly delivered mothers on postpartum blues. A prospective, two-arm, randomized controlled study was conducted on = 82 (41 = control, 41 = music group) mothers