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N-linked α2,6-sialylation of integrin β1 by the sialyltransferase ST6Gal1 promotes cell proliferation and stemness in gestational trophoblastic disease Placenta (IF 3.8) Pub Date : 2024-03-11 Jianwei Liu, Xinyue Dong, Ru Xie, Ying Tang, Aline M. Thomas, Shen Li, Shuai Liu, Ming Yu, Huamin Qin
Gestational trophoblastic disease (GTD) encompasses a spectrum of rare pre-malignant and malignant entities originating from trophoblastic tissue, including partial hydatidiform mole, complete hydatidiform mole and choriocarcinoma. β-galactoside α2,6 sialyltransferase 1 (ST6Gal1), the primary sialyltransferase responsible for the addition of α2,6 sialic acids, is strongly associated with the occurrence
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A longitudinal and cross-sectional study of placental circulation between normal and placental insufficiency pregnancies Placenta (IF 3.8) Pub Date : 2024-03-11 J.Y. Chen, B.L. Yu, X.J. Wu, Y.F. Li, L.Y. Zhong, M. Chen
To longitudinally and cross-sectionally study the differences in the uterine artery pulsatility index (UTPI), umbilical artery pulsatility index (UAPI) and placental vascularization indices (PVIs, derived from 3-dimensional power Doppler) between normal and placental insufficiency pregnancies throughout gestation. UTPI, UAPI and PVI were measured 6 times at 4- to 5- week intervals from 11-13 weeks–36
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HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions Placenta (IF 3.8) Pub Date : 2024-03-11 Mayuri Bora, Sushmita Singha, Taruna Madan, Gitanjali Deka, Sumita Gogoi Hazarika, Shashi Baruah
Spontaneous abortion (SAB) affects approximately 10% of clinically recognized pregnancies. Fetal trophobalst invasion and remodeling of maternal spiral arteries is reported to be dependent on crosstalk between HLA-C/HLA-G expressed on extra villous trophoblast (EVTs)and Killer cell Immunoglobin like receptors (KIRs) of decidual NK (dNK). Immune dysfunction in decidua contributes to early miscarriage
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PFAS alters placental arterial vasculature in term human placentae: A prospective pregnancy cohort study Placenta (IF 3.8) Pub Date : 2024-03-09 Sadia Firoza Chowdhury, Nashae Prout, Zorimar Rivera-Núñez, Emily Barrett, Jessica Brunner, Zoe Duberstein, Kurunthachalam Kannan, Carolyn M. Salafia, Ruchit Shah, Richard K. Miller, Thomas G. O'Connor
Perfluoroalkyl substances (PFAS) are synthetic chemicals used in industrial and consumer goods that are widely detected in human populations and are associated with adverse health outcomes, including perinatal health risks and child health. One mechanism of influence may be the impact of PFAS exposure on placental structure and function. The objective of this study is to investigate the relationship
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Whole exome sequencing of placental chorangioma Placenta (IF 3.8) Pub Date : 2024-03-08 Rachelle P. Mendoza, Kristina Doytcheva, Minhaz Ud Dean, Kyla M. Jorgenson, Donghyuk Choi, Jeremy Segal, Peng Wang, Ricardo R. Lastra
Placental chorangioma is a benign non-trophoblastic vascular proliferation of the placental chorion favored to represent hamartoma-like or hyperplastic capillary lesions. As the exact pathophysiology has not been established, we investigated the molecular characteristics of placental chorangiomas using exploratory whole exome sequencing. Three cases were retrospectively selected and whole exome sequencing
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Two-dimensional (2D) placental ultrasound measurements – The correlation with placental volume measured by magnetic resonance imaging (MRI) Placenta (IF 3.8) Pub Date : 2024-02-28 Karianne Sagberg, Anne Eskild, Silje Sommerfelt, Tuva K. Halle, Vigdis Hillestad, Camilla Haavaldsen
Information about placental size in ongoing pregnancies may aid the identification of pregnancies with increased risk of adverse outcome. Placental volume can be measured using magnetic resonance imaging (MRI). However, this method is not universally available in antenatal care. Ultrasound is the diagnostic tool of choice in pregnancy. Therefore, we studied whether simple two-dimensional (2D) ultrasound
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Improved neonatal outcomes in pregnancies with coexisting gestational diabetes and preeclampsia in normal birthweight neonates- insights from a retrospective cohort study Placenta (IF 3.8) Pub Date : 2024-02-27 Liat Mor, Liliya Tamayev, Barak Laxer, Ella Toledano, Letizia Schreiber, Yael Ganor Paz, Giulia Barda, Michal Levy, Eran Weiner
We aimed to assess neonatal and maternal outcomes in appropriate-for-gestational-weight (AGA) neonates of mothers with both gestational diabetes mellitus (GDM) and preeclampsia (PET). Medical records of women diagnosed with GDM or PET were reviewed. Women with AGA neonates were divided into three groups- GDM, PET, and GDM + PET and maternal neonatal and placental outcomes were compared. The primary
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IFPA Joan Hunt Senior Award in Placentology lecture: Extracellular vesicle signalling and pregnancy Placenta (IF 3.8) Pub Date : 2024-02-23 Gregory E. Rice, Carlos Salomon
The field of extracellular vesicle (EV) signalling has the potential to transform our understanding of maternal-fetal communication and affords new opportunities for non-invasive prenatal testing and therapeutic intervention. EVs have been implicated in implantation, placentation, maternal adaptation to pregnancy and complications of pregnancy, being detectable in maternal circulation as early as 6
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Placentae of small appropriately-grown-for-gestational-age neonates exhibit sexually dimorphic transcriptomic changes representative of placental insufficiency Placenta (IF 3.8) Pub Date : 2024-02-23 Adam Ewing, Jessica L. O'Callaghan, Sharon McCracken, Stacy Ellery, Martha Lappas, Olivia J. Holland, Anthony Perkins, Zarqa Saif, Vicki L. Clifton
Previous studies have reported that neonates less than the 25th BWC especially if they were male, were more likely to be associated with birth complications suggesting small neonates often identified as appropriately grown are at risk of adverse outcomes. We have questioned whether smaller neonates not typically categorized as “small for gestational age” may not reach their genetically determined growth
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Association between CORIN promoter methylation and hypertensive disorders of pregnancy – A nested case-control study Placenta (IF 3.8) Pub Date : 2024-02-23 Wenxiu Fan, Yuanyuan Mao, Lei Wu, Pei Feng, Xueyang Zhang, Jianwei Hu, Yibing Jin, Xiangdong Yang, Hongmei Li, Qin Liu, Hao Peng
Corin protein and its coding gene variants have been associated with hypertensive disorders of pregnancy (HDP), but the underlying mechanisms are unclear. As a mediator linking fixed genome with the dynamic environment, DNA methylation at the gene may link corin with HDP but not has been studied. This study aimed to examine whether promoter methylation and HDP in Chinese pregnant women. Based on a
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Engineering placental trophoblast fusion: A potential role for biomechanics in syncytialization Placenta (IF 3.8) Pub Date : 2024-02-21 Prabu Karthick Parameshwar, Cathy Vaillancourt, Christopher Moraes
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Placental weight, surface area, shape and thickness - Relations with maternal ethnicity and cardio-metabolic factors during pregnancy Placenta (IF 3.8) Pub Date : 2024-02-15 Line Sletner, Chittaranjan S. Yajnik, Gitta Turowski, Trond M. Michelsen, Christine Sommer, Kåre I. Birkeland, Borghild Roald, Anne Karen Jenum
A better understanding of the determinants of placental growth is needed. Our primary aim was to explore associations between maternal ethnic origin and cardio-metabolic factors during pregnancy, and placental weight, surface area, shape and thickness. A multi-ethnic population-based cohort study of 474 pregnant women examined at mean 15 and 28 weeks’ gestation. Placentas were inspected after birth
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Evaluation of utero-placental vascularization using contrast-enhanced ultrasound: Early first trimester maternal perfusion of the intervillous space is confirmed Placenta (IF 3.8) Pub Date : 2024-02-13 C. Bertholdt, O. Morel, G. Hossu, A. Cherifi, M. Beaumont, M.L. Eszto
The objective was to confirm and semiquantify the maternal perfusion of the intervillous space between 8 and 13 + 6 gestational weeks (GW). We conducted a prospective, multicenter, and nonrandomized open study. Women undergoing voluntary termination of pregnancy at three different gestational ages (Group 8 GW: 8 to 8 + 6 GW, Group 11GW: 11 to 11 + 6 GW and Group 13GW: 13 to 13 + 6 GW) were included
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Induction of human-fetal-membrane remodeling in-vitro by the alpha hemolysin of Escherichia coli Placenta (IF 3.8) Pub Date : 2024-02-13 Melisa Pucci Molineris, Florencia Schibert, María Lima, Paula Accialini, Lucía Cané, Pablo Pelinsky, Mariana Farina, Vanesa Herlax
Almost 80% of urinary tract infections during pregnancy are caused by uropathogenic strains of . Alpha-hemolysin, toxin secreted by them, has a fundamental role in this pathology development. Considering that urinary tract infections are related with premature rupture of fetal membranes, we proposed to evaluate the effects that alpha-hemolysin induces on human-fetal-membranes. Thirteen fetal membranes
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COVID-19 vaccination protects infected pregnant women from developing SARS-CoV-2 placentitis and decreases the risk for stillbirth Placenta (IF 3.8) Pub Date : 2024-02-10 Gitte Zels, Cecile Colpaert, Dorien Leenaerts, Heleen Nailis, Magali Verheecke, Luc De Catte, Jute Richter, Marcella Baldewijns
The impact of COVID-19 infection in pregnant women remained unclear for a long time. Previous research showed that SARS-CoV-2 virus is able to infect the placenta, potentially causing significant lesions leading to placental insufficiency. The impact of maternal vaccination status on the prevalence of SARS-CoV-2 placentitis remains unclear. We characterized placental lesions in SARS-CoV-2 infected
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The role of ERp29/FOS/EMT pathway in excessive apoptosis of placental trophoblast cells in intrahepatic cholestasis of pregnancy Placenta (IF 3.8) Pub Date : 2024-02-08 Gaoying Wang, Ruirui Dong, Haijian Zhao, Ningzhen Ye, Jing Wang, Jing Cheng, Xinrui Shi, Liang Luo, Ting Zhang
Abnormal bile acid metabolism leading to changes in placental function during pregnancy. To determine whether endoplasmic reticulum protein 29 (ERp29) can mediate the pregnancy effects of cholestasis by altering the level of trophoblast cell apoptosis. ERp29 in serum of 66 intrahepatic cholestasis of pregnancy (ICP) pregnant women and 74 healthy were detected by ELISA. Subcutaneous injection of ethinyl
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First-trimester 3D power Doppler imaging markers of utero-placental vascular development are associated with placental weight and diameter at birth: The Rotterdam Periconception Cohort Placenta (IF 3.8) Pub Date : 2024-02-08 Eline S. de Vos, Lotte E. van der Meeren, Anton H.J. Koning, Peter G.J. Nikkels, Eric A.P. Steegers, Régine P.M. Steegers-Theunissen, Annemarie G.M.G.J. Mulders
Early utero-placental vascular development impacts placental development and function throughout pregnancy. We investigated whether impaired first-trimester utero-placental vascular development is associated with pathologic features of the postpartum placenta. In this prospective observational study of 65 ongoing pregnancies, we obtained three-dimensional power Doppler ultrasounds of the placenta at
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Placental energy metabolism: Evidence for a placental-maternal lactate-ketone trade in the human Placenta (IF 3.8) Pub Date : 2024-02-05 Tore Henriksen, Muhammad U. Sajjad, Guttorm Haugen, Trond M. Michelsen
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Nicotine regulates abnormal macrophage polarization and trophoblast invasion associated with preterm labor via the α7nAChR/SIRT1 axis Placenta (IF 3.8) Pub Date : 2024-01-29 Aihua Ye, Liling Li, Haozhong Chen, Ping Tao, Shuiping Lou
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Involvement of GAT2/Slc6a13 in hypotaurine uptake at fetal-facing plasma membrane of syncytiotrophoblasts at mid-to-late gestation in rats and mice Placenta (IF 3.8) Pub Date : 2024-02-02 Tomohiro Nishimura, Hikari Araki, Kei Higuchi, Saki Noguchi, Kei Saito, Kanako Hara, Haruya Yagishita, Risa Akashi, Sakiko Obata, Masatoshi Tomi
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Altered release of thrombomodulin and HMGB1 in the placenta complicated with preeclampsia Placenta (IF 3.8) Pub Date : 2024-02-01 Hiroko Oda, Takeshi Nagamatsu, Takayuki Iriyama, Yutaka Osuga
Preeclampsia (PE) is a severe pregnancy complication due to placental dysfunction. Thrombomodulin (TM), a glycoprotein expressed on the trophoblast cell membrane, plays an organ-protective role in the placenta by regulating coagulation and inflammation. TM-mediated regulation of High Mobility Group Box1(HMGB1) is an essential mechanism that contributes to placental homeostasis and prevents pregnancy
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MiR-155-5p improves the insulin sensitivity of trophoblasts by targeting CEBPB in gestational diabetes mellitus Placenta (IF 3.8) Pub Date : 2024-02-01 Huiting Zhang, Yi Jiang, Shenglan Zhu, Lijie Wei, Xuan Zhou, Peng Gao, Jingyi Zhang, Yuting Chen, Yuanyuan Du, Chenyun Fang, Rui Su, Jiaqi Li, Shaoshuai Wang, Ling Feng
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication featuring impaired insulin sensitivity. MiR-155-5p is associated with various metabolic diseases. However, its specific role in GDM remains unclear. CCAAT enhancer binding protein beta (CEBPB), a critical role in regulating glucolipid metabolism, has been identified as a potential target of miR-155-5p. This study aims to investigate
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HtrA4 is required for human trophoblast stem cell differentiation into syncytiotrophoblast Placenta (IF 3.8) Pub Date : 2024-02-01 Bothidah Thach, Yao Wang, Sophea Heng, Guiying Nie
The syncytiotrophoblast (STB) of the human placenta facilitates vital maternal-fetal communication and is maintained by fusion (syncytialization) of cytotrophoblasts. Serine protease HtrA4 (high temperature requirement factor A4) is highly expressed only in the human placenta and was previously reported to be important for BeWo fusion. This study investigated whether HtrA4 is critical for differentiation
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Placental cellular composition and umbilical cord tissue metal(loid) concentrations: A descriptive molecular epidemiology study leveraging DNA methylation Placenta (IF 3.8) Pub Date : 2024-01-24 Catherine M. Bulka, Husena M. Rajkotwala, Lauren A. Eaves, Amaree J. Gardner, Patrick J. Parsons, Aubrey L. Galusha, T. Michael O'Shea, Rebecca C. Fry
The placenta is a mixture of cell types, which may regulate maternal-fetal transfer of exogenous chemicals or become altered in response to exposures. We leveraged placental DNA methylation to characterize major constituent cell types and applied compositional data analysis to test associations with non-essential metal(loid)s measured in paired umbilical cord tissue (N = 158). Higher proportions of
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Synthesis of phospholipids in human placenta Placenta (IF 3.8) Pub Date : 2024-01-21 Theresa L. Powell, Veronique Ferchaud-Roucher, Lana Madi, Charis Uhlson, Karin Zemski-Berry, Avery C. Kramer, Kathryn Erickson, Claire Palmer, Stephanie S. Chassen, Marisol Castillo-Castrejon
Introduction Placental phospholipid synthesis is critical for the expansion of the placental exchange surface area and for production of signaling molecules. Despite their importance, it is not yet established which enzymes involved in the de novo synthesis and remodeling of placental phospholipids are expressed and active in the human placenta. Methods We identified phospholipid synthesis enzymes
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Non-hypertensive gestational diabetes mellitus: Placental histomorphology and its association with perinatal outcomes Placenta (IF 3.8) Pub Date : 2024-01-23 Yip Meng Lai, Geok Chin Tan, Shamsul Azhar Shah, Rahana Abd Rahman, Muhamad Fakhri Mohd Saleh, Suhada Mansor, Teck Yee Khong, Yin Ping Wong
Introduction Gestational diabetes mellitus (GDM) exerts a great impact on the placenta and reflects changes on placentas both morphological and functionally. The aims of this study are to evaluate the prevalence of placental histopathological lesions in pregnancies complicated by GDM compared to gestational age-matched controls, and their association with maternal and fetal complications. Methods Fifty-four
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TET3-mediated novel regulatory mechanism affecting trophoblast invasion and migration: Implications for preeclampsia development Placenta (IF 3.8) Pub Date : 2024-01-26 Cong Wang, Huihui Ju, Lihong Zhou, Yuanyuan Zhu, Liuxin Wu, Xiaokang Deng, Lingling Jiang, Lizhou Sun, Yetao Xu
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Urine congophilia associated with preeclampsia does not persist 6-months postpartum Placenta (IF 3.8) Pub Date : 2024-01-26 P. Hofstee, J.S. Lum, Y.Y. Chow, M.R. Wittwer, M. Arstall, G. Dekker, V.L. Clifton, I.M. Wright, M.A. Kelly, H. Ecroyd
Introduction Preeclampsia is a common hypertensive disorder of pregnancy. Several studies have demonstrated that protein aggregates, detected through urine congophilia, is associated with preeclampsia; however, it has yet to be investigated whether urine congophilia remains postpartum in these women. In this study, we aimed to augment prior studies and determine whether urine congophilia is present
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Novel high throughput screen reports that benzo(a)pyrene overrides mouse trophoblast stem cell multipotency, inducing SAPK activity, HAND1 and differentiated trophoblast giant cells Placenta (IF 3.8) Pub Date : 2024-01-19 B.L. Kidder, X. Ruden, A. Singh, T.A. Marben, L. Rass, A. Chakravarty, Y. Xie, E.E. Puscheck, A.O. Awonuga, S. Harris, D.M. Ruden, D.A. Rappolee
Introduction Cultured mouse trophoblast stem cells (mTSC) maintain proliferation/normal stemness (NS) under FGF4, which when removed, causes normal differentiation (ND). Hypoxic, or hyperosmotic stress forces trophoblast giant cells (TGC) differentiate. Hypoxic, hyperosmotic, and genotoxic benzo(a)pyrene (BaP), which is found in tobacco smoke, force down-regulation of inhibitor of differentiation (Id)2
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OLFML3 suppresses trophoblast apoptosis via the PI3K/AKT pathway: A possible therapeutic target in preeclampsia Placenta (IF 3.8) Pub Date : 2024-01-19 Haiying Chen, Ruiping Li, Jiangyujing Bian, Xiaoqing Li, Cunjing Su, Yang Wang, Hongping Zhang, Jianqiong Zheng, Yeping Wang, Hong Zhang
Introduction Preeclampsia (PE) is a pregnancy complication that encompasses various pathogenic mechanisms. Shallow implantation of the placenta due to abnormal trophoblast behavior is considered an important mechanism underlying PE; however, its exact etiology remains unclear. Methods The expression of OLFML3 in the placenta and important clinical indicators were performed, followed by a correlation
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Preeclamptic serum and soluble fms-like tyrosine kinase-1 suppress endothelial inward rectifier potassium currents Placenta (IF 3.8) Pub Date : 2024-01-11 Wuttinan Theerathananon, Wattana B. Watanapa, Tuangsit Wataganara, Busadee Pratumvinit, Suraiya Rahman
Introduction Inward rectifier K+ (Kir) channel, a major factor determining endothelial membrane potential, regulates Ca2+ influx and vasodilator release, which is impaired in preeclamptic blood vessels. Previously, human umbilical vein endothelial cell (HUVEC) Kir currents were shown to decrease after incubating in preeclamptic plasma. We aimed to demonstrate whether sFlt-1, which is high in preeclamptic
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Real-time fetal monitoring using photoacoustic measurement of placental oxygen saturation in a rabbit hypoxia model Placenta (IF 3.8) Pub Date : 2024-01-14 Kiguna Sei Okawa, Takeshi Hirasawa, Shinpei Okawa, Masanori Fujita, Miya Ishihara
Introduction Ensuring adequate fetal oxygenation is an essential aim of fetal monitoring. The purpose of this study was to establish a basic technique for real-time measurement of blood oxygen saturation of the placenta by photoacoustic (PA) technique as a new fetal monitoring method. Methods The hypoxia model established in our previous study was applied to 7 pregnant rabbits. Three phases were induced:
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Human placenta releases extracellular vesicles carrying corticotrophin releasing hormone mRNA into the maternal blood Placenta (IF 3.8) Pub Date : 2024-01-05 Nilanjana Paul, Kaushik Maiti, Zakia Sultana, Joshua J. Fisher, Huiming Zhang, Nicole Cole, Terry Morgan, Roger Smith
The human placenta releases diverse extracellular vesicles (EVs), including microvesicles (100–1000 nm) and exosomes (30–150 nm), into the maternal blood for feto-maternal communication. Exosomes and microvesicles contribute to normal pregnancy physiology and major pregnancy pathologies. Differences in miRNA expressions and protein content in placental exosomes have been reported in complicated pregnancies
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Placenta Accreta Spectrum: Evaluation of classic and non-classic presentations, pathologic grading, and uterine scar dehiscence features in a modern institutional series Placenta (IF 3.8) Pub Date : 2024-01-03 Grace Neville, Daniela Carusi, Hope Y. Yu, Aarti Sharma, Bradley J. Quade, Carlos Parra-Herran
Introduction The aim of this study is to document the distribution of classic versus non-classic presentation of Placenta Accreta Spectrum (PAS) disorders as well as grading categories by the Society for Pediatric Pathology (SPP) and FIGO systems in an institutional cohort of gravid hysterectomies. We also document the prevalence of uterine scar as a histologic correlate for uterine scar dehiscence
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Visual identification of three kinds of human decidual tissues from elective termination of pregnancy Placenta (IF 3.8) Pub Date : 2024-01-05 Ziwei Yin, Jingjing Su, Linsen Lu, Liangliang Yang, Shiyue Su, Xiangxiang Jiang
Introduction The decidua can be classified into the decidua basalis, decidua capsularis and decidua parietalis. This study aimed to visually identify these three kinds of decidual tissues from fresh samples obtained in early pregnancy based on their macroscopic appearances, which can be discerned visually. Methods Decidual samples were collected from 15 pregnant women between 6 and 8 weeks of gestation
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Influence of forkhead box protein 3 gene polymorphisms in recurrent pregnancy loss: A meta-analysis Placenta (IF 3.8) Pub Date : 2024-01-04 Chitra Bamba, Minakshi Rohilla, Anu Kumari, Anupriya Kaur, Priyanka Srivastava
Background Treg cells play an important role in development of tolerance in maternal immune system against the semi-allogenic embryo. Human forkhead box protein 3 (FOXP3) gene, is the major transcription factor responsible for the regulation of Treg function during pregnancy. Single nucleotide polymorphisms (SNPs) of FOXP3 gene have been reported as a risk factor for Recurrent Pregnancy Loss (RPL)
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Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction Placenta (IF 3.8) Pub Date : 2023-12-28 Qing Hua, Zhe Li, Yadan Zhou, Yali Wang, Yangyang Yu, Lei Sun, Jianping Ye, Li Li
Introduction Fetal growth restriction (FGR) can lead to fetal mental development abnormalities, malformations, and even intrauterine death. Defects in the trophoblasts at the maternal-fetal interface may contribute to FGR. However, the impact of trophoblasts on FGR is still not well understood. Therefore, the objective of this study is to characterize the heterogeneity of placental cells at the single-cell
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Significant association between circumvallate placenta, placental abruption and acute chorioamnionitis in preterm birth: A 23-year retrospective cohort study Placenta (IF 3.8) Pub Date : 2023-12-27 D.G. Stuijt, M. Bos, P.G.J. Nikkels, R. Wolterbeek, L.E. van der Meeren
Aim circumvallate placenta, placental abruption and acute chorioamnionitis separately are associated with unfavourable clinical outcomes. We aimed to determine the prevalence and define whether an association exists between the three abnormalities. Methods 16,042 placenta pathology reports between 1997 and 2020 from a tertiary care centre in the Netherlands were retrospectively analysed. For the statistical
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Artery-to-vein anastomoses in unequally divided placentas and their association with birthweight discordance Placenta (IF 3.8) Pub Date : 2023-12-30 A.T.R. Noll, F.C. Lof, S.G. Groene, M.C. Haak, E. Lopriore, F.M. Russo, F. Slaghekke, L.S.A. Tollenaar, J. Van der Merwe, E.J.T. Verweij, L. Lewi
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Role of paralogs in the sex-bias transcriptional and metabolic regulation of the brain-placental axis in mice Placenta (IF 3.8) Pub Date : 2023-12-19 Maliha Islam, Susanta K. Behura
Introduction Duplicated genes or paralogs play important roles in the adaptive function of eukaryotic genomes. Animal studies have shown evidence for the functional role of paralogs in pregnancy, but our knowledge about the role of paralogs in the fetoplacental regulation remains limited. In particular, if fetoplacental metabolic regulation is modulated by differential expression of paralogs remains
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Two-dimensional phase-contrast MRI reveals changes in uterine arterial blood flow in pregnant women administered tadalafil for fetal growth restriction Placenta (IF 3.8) Pub Date : 2023-12-23 Masafumi Nii, Naosuke Enomoto, Masaki Ishida, Shoichi Magawa, Sho Takakura, Shintaro Maki, Kayo Tanaka, Kuniaki Toriyabe, Hiroaki Tanaka, Eiji Kondo, Hajime Sakuma, Tomoaki Ikeda
Introduction We aimed to examine the effect of uterine arterial (UtA) blood flow changes after tadalafil treatment for fetal growth restriction (FGR) using two-dimensional (2D) phase-contrast magnetic resonance imaging (PC-MRI). Methods We recruited 14 pregnant women with FGR aged 20–44 years, at ≥20 weeks’ gestation, between May 2019 and July 2020. They underwent 2D PC-MRI for UtA blood flow measurement
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A real-life prospective blinded evaluation of placental biometry and macroscopic morphology from 1008 unselected consecutive pregnancies Placenta (IF 3.8) Pub Date : 2023-12-22 Chiara Tasca, Francesca Parisi, Marta Zambon, Susanna Bonato, Martina Bombelli, Roberta Simona Rossi, Emilio Caselli, Duccio Petrella, Manuela Nebuloni, Irene Cetin
Introduction The study of the macroscopic appearance of the placenta may represent a useful tool to understand the pathophysiology of adverse pregnancy outcomes. The aim of this study was to evaluate biometry and morphology of placentas in relation to maternal, neonatal and pregnancy course characteristics. Methods Clinical and placental data (biometry and macroscopic features of chorionic disk and
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Placental pathology in a large (Swedish) cohort of SARS-CoV-2 infected mothers Placenta (IF 3.8) Pub Date : 2023-12-15 Lisa Fredriksson, Evelina Tidholm Qvist, Meeli Sirotkina, Karin Pettersson, Nikos Papadogiannakis
Introduction SARS-CoV-2 placentitis is associated with placental destruction and insufficiency and can affect perinatal outcome. The aim of the current study was to contribute with increased knowledge regarding placental histology in maternal SARS-CoV-2 infection during the pregnancy, as well as the correlation to the severity of maternal SARS-CoV-2 infection. Material and methods This retrospective
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Transplacental migration of maternal natural killer and T cells assessed by ex vivo human placenta perfusion Placenta (IF 3.8) Pub Date : 2023-12-20 Diana M. Morales-Prieto, Kathrin Wieditz, Juliane Götze, Jana Pastuschek, Maja Weber, Claudia Göhner, Tanja Groten, Udo R. Markert
Introduction The transplacental passage of cells between a mother and her fetus, known as microchimerism, is a less studied process during pregnancy. The frequency of maternal microchimeric cells in fetal tissues in physiological pregnancies and mechanisms responsible for transplacental cell trafficking are poorly understood. This study aimed to evaluate the placental trafficking of maternal peripheral
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Maternal serum amino acid levels as predictors of premature rupture of membranes: A comprehensive analysis Placenta (IF 3.8) Pub Date : 2023-12-15 Savas Karakus, Halef Okan Dogan
Introduction The aim of this study is to investigate the association between altered maternal serum amino acids (AAs) levels and premature rupture of membranes (pPROM) in pregnant women. Methods We conducted a case-control study involving 60 pregnant women diagnosed with pPROM and 60 healthy pregnant women as controls. Amino acid levels were quantified using high-performance liquid chromatography.
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Association between maternal diet, smoking, and the placenta MTHFR 677C/T genotype and global placental DNA methylation Placenta (IF 3.8) Pub Date : 2023-12-19 Hector Diaz-Garcia, Jenny Vilchis-Gil, Karla V. Castro-Cerritos, Luis E. Rivera-Susunaga, Miguel Klünder-Klünder, Javier T. Granados-Riveron, Jaqueline Gómez-López, Adolfo López-Torres, Rocío Sánchez-Urbina
Introduction The placenta provides nutrients to the fetus, and it has protective effects against harmful substances. Unhealthy maternal diets and toxic agents might increase free radical (FR) production. Elevated FR levels are associated with a high risk of oxidative stress, which may cause DNA damage. DNA might be oxidized in the placenta, occasionally affecting its methylation profile due to 8-h
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Novel high throughput screen reports that benzo(a)pyrene overrides trophoblast stem cell multipotency, inducing SAPK activity, HAND1 and differentiated trophoblast giant cells Placenta (IF 3.8) Pub Date : 2023-12-13 B.L. Kidder, X. Ruden, A. Singh, T.A. Marben, L. Rass, A. Chakravarty, Y. Xie, E.E. Puscheck, A.O. Awonuga, S. Harris, D.M. Ruden, D.A. Rappolee
Introduction Cultured mTSC maintain proliferation/normal stemness (NS) unless FGF4 is removed, causing normal differentiation (ND). Hypoxic, or hyperosmotic stress force trophoblast giant cells (TGC) differentiation. Hypoxic, hyperosmotic, and genotoxic benzo(a)pyrene (BaP) force down-regulation of inhibitor of differentiation (Id)2, enabling TGC differentiation. Hypoxic and hyperosmotic stress induce
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Fetal endothelial colony-forming cells: Possible targets for prevention of the fetal origins of adult diseases Placenta (IF 3.8) Pub Date : 2023-12-10 , Baitao Ma, Xianlan Zhao
Endothelial colony-forming cells (ECFCs), a subset of circulating and resident endothelial progenitor cells, are capable of self-renewal and de novo vessel formation, and are known key regulators of vascular integrity and homeostasis. Numerous studies have found that exposure to hostile environment during the fetal development exerts a profound influence on the level and function of ECFCs, which may
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A validation of placental pathology reports by ethnicity in New Zealand, through systematic analysis of histological slides Placenta (IF 3.8) Pub Date : 2023-12-15 Esti de Graaff, Ngaire Anderson, Lynn Sadler, Heena Lakhdhir, Rachel Simon-Kumar, Roshini Peiris-John, Wendy Burgess, Karaponi Okesene-Gafa, Robin Cronin, Lesley McCowan, Kate Bartlett
Introduction Reliability studies of placental examination have shown differing interobserver agreement for certain pathological features, a lack of uniform reporting criteria and variable experience among pathologists. In previous analyses we have shown that placental pathology differs by ethnicity. This validation study was performed to investigate whether bias related to ethnicity is a feature of
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Placental cell conditioned media modifies hematopoietic stem cell transcriptome in vitro Placenta (IF 3.8) Pub Date : 2023-12-15 Sean M. Harris, Anthony L. Su, John F. Dou, Rita Loch-Caruso, Elana R. Elkin, Sammy Jaber, Kelly M. Bakulski
Introduction Hematopoietic stem cells are cells that differentiate into blood cell types. Although the placenta secretes hormones, proteins and other factors important for maternal/fetal health, cross-talk between placental and hematopoietic stem cells is poorly understood. Moreover, toxicant impacts on placental-hematopoietic stem cell communication is understudied. The goals of this study were to
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The normality of the first-trimester placentae collected from elective terminations Placenta (IF 3.8) Pub Date : 2023-12-15 Hua Fang, Jinqiu Zhang, Jiayuan Wang, Bridget W. Tsai, Ye Shen, Qi Chen
Placentae collected from elective terminations during the first trimester are commonly used as control samples in research. However, it is widely acknowledged that many complications of pregnancies can occur or originate during the early stage of gestation. This raises the question that the placentae collected from the first trimester may not accurately reflect normal placental conditions. In this
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Reference range of placental growth factors at 11–14 weeks’ gestation in Indonesia Placenta (IF 3.8) Pub Date : 2023-12-14 Detty Siti Nurdiati, Aditya Kusuma, Adly Nanda Al Fattah, Nining Handayani
Objectives To develop a reference chart for placental growth factor (PLGF) value during 11–14 weeks’ gestation in Indonesian population. Methods This was an observational study observing women in their first trimester. Maternal characteristics, biophysical tests, and serum PLGF levels were collected during the visit. PLGF Multiple of Median (MoM) was adjusted for maternal characteristics including
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Angiogenic growth factors, oxidative stress and haematobiochemical measures as predictors of preeclampsia with and without foetal growth restriction: A case-control study in a Ghanaian population Placenta (IF 3.8) Pub Date : 2023-12-12 Enoch Odame Anto, Wina Ivy Ofori Boadu, Charity Hughes, Emmanuel Ekow Korsah, Joseph Frimpong, Ezekiel Ansah, Augustine Tawiah, Valentine Christian Kodzo Tsatsu Tamakloe, Emmanuel Acheampong, Evans Adu Asamoah, Stephen Opoku, Elizabeth Aboagye, Etwi-Mensah Albright, Eric Adua, Ebenezer Afrifa-Yamoah, Agartha Odame Anto, Max Efui Annani-Akollor, Yaw Amo Wiafe, Christian Obirikorang
Introduction This study compares the angiogenic growth mediators (AGMs), oxidative stress (OS) and haematobiochemical profile as well as foeto-maternal outcomes of preeclampsia (PE) with and without foetal growth restriction (FGR) and the discriminative potential of these markers for identifying these conditions. Methods This hospital-based case-control study recruited a total of 209 women including
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Immune-regulatory properties of endovascular extravillous trophoblast cells in human placenta Placenta (IF 3.8) Pub Date : 2023-12-12 Yeling Ma, Xin Yu, Shenglong Ye, Wenlong Li, Qian Yang, Yu-xia Li, Yongqing Wang, Yan-Ling Wang
Introduction Uterine spiral artery remodeling is the prerequisite for ensuring adequate blood supply to the maternal-fetal interface during human pregnancy. One crucial cellular event in this process involves the extensive replacement of the spiral artery endothelial cells by endovascular extravillous trophoblasts (enEVTs), a subtype of extravillous trophoblasts (EVTs). However, our understanding of
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ADAM9 deubiquitination induced by USP22 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells in preeclampsia Placenta (IF 3.8) Pub Date : 2023-12-11 Jie Liu, Yan Wang, Suqin Zhang, Liyan Sun, Yanmei Shi
Introduction The dysregulation of deubiquitination has been shown to affect the development of pre-eclampsia (PE). A disintegrin and metalloprotease 9 (ADAM9) plays roles in diverse physiological contexts, including PE. Here, this study aimed to investigate whether ADAM9 regulated trophoblast cell dysfunction through ubiquitin-specific protease 22 (USP22) deubiquitinase-mediated deubiquitination during
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Placental size at gestational week 27 and 37: The associations with pulsatility index in the uterine and the fetal-placental arteries Placenta (IF 3.8) Pub Date : 2023-12-04 Carl Petter Skaar Kulseng, Silje Sommerfelt, Kari Flo, Kjell-Inge Gjesdal, Helene Fjeldvik Peterson, Vigdis Hillestad, Anne Eskild
Introduction Fetal growth restriction is known to be related to decreased fetal and placental blood flow. It is not known, however, whether placental size is related to fetal and placental blood flow. We studied the correlations of intrauterine placental volume and placental-fetal-ratio with pulsatility index (PI) in the uterine arteries, fetal middle cerebral artery, and umbilical artery. Methods
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Luteolin prevents TNF-α-induced NF-κB activation and ROS production in cultured human placental explants and endothelial cells Placenta (IF 3.8) Pub Date : 2023-12-08 Adrian C. Eddy, Augustine Rajakumar, Frank T. Spradley, Joey P. Granger, Sarosh Rana