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Mitochondrial dysfunction and oxidative stress in selective fetal growth restriction Placenta (IF 3.0) Pub Date : 2024-09-10 Yucheng Hu, Yuhong Lin, Jiawen Yang, Shan Wang, Li Gao, Yan Bi, Yanlin Wang
Placental dysfunction is the primary cause of selective fetal growth restriction (sFGR), and the specific role of mitochondria remains unclear. This study aims to elucidate mitochondrial functional defects in sFGR placentas and explore the roles of mitochondrial genomic and epigenetic alterations in its pathogenesis. The placental villi of MCDA twins with sFGR were collected and the morphology and
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Trophoblast Research Editorial 27th International Federation of Placenta Associations Conference, Rotorua, New Zealand Placenta (IF 3.0) Pub Date : 2024-09-07 Larry Chamley
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A straightforward cell culture insert model to incorporate biochemical and biophysical stromal properties into transplacental transport studies Placenta (IF 3.0) Pub Date : 2024-09-05 Katherine M. Nelson, Bryan J. Ferrick, Hassan Karimi, Christine L. Hatem, Jason P. Gleghorn
The placental extracellular matrix (ECM) dynamically remodels over pregnancy and in disease. How these changes impact placental barrier function is poorly understood as there are limited models of the placenta with a modifiable stromal compartment to mechanistically investigate these extracellular factors. We developed a straightforward method to incorporate uniform hydrogels into standard cell culture
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KLF6 negatively regulates HIF-1α in extravillous trophoblasts under hypoxia Placenta (IF 3.0) Pub Date : 2024-09-05 Ana C. Racca, Sofía Nardi, Jésica Flores-Martin, Susana Genti-Raimondi, Graciela M. Panzetta-Dutari
HIF-1α, the master regulator of hypoxia cellular response, is stabilized under low oxygen levels and degraded in the presence of oxygen but its transcription, translation, and degradation are tightly regulated by numerous pathways. KLF6 is a transcription factor involved in proliferation, differentiation, and apoptosis in several cell systems. Under hypoxia it is upregulated in a HIF-1α-dependent manner
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Obituary to the IFPA Journal: Placenta - Date: August 16, 2024 Placenta (IF 3.0) Pub Date : 2024-09-02 Christopher Redman
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Feto-placental and coronary endothelial genes implicated in miscarriage, congenital heart disease and stillbirth, a systematic review and meta-analysis Placenta (IF 3.0) Pub Date : 2024-09-01 Jacinta I. Kalisch-Smith, Nusaybah Ehtisham-Uddin, Helena Rodriguez-Caro
The first trimester placenta is very rarely investigated for placental vascular formation in developmental or diseased contexts. Defects in placental formation can cause heart defects in the fetus, and vice versa. Determining the causality is therefore difficult as both organs develop concurrently and express many of the same genes. Here, we performed a systematic review to determine feto-placental
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Utility of placental biomarkers and fetoplacental Dopplers in predicting likely placental pathology in early and late fetal growth restriction – A prospective study Placenta (IF 3.0) Pub Date : 2024-08-30 Jesrine Hong, Kylie Crawford, Matthew Daly, Vicki Clifton, Fabricio da Silva Costa, Anthony V. Perkins, Admire Matsika, Rohan Lourie, Sailesh Kumar
The aim of this study was to evaluate the association between placental abnormalities, placental biomarkers, and fetoplacental Dopplers in a cohort of pregnancies complicated by fetal growth restriction (FGR). We also ascertained the risk of perinatal mortality, severe neurological morbidity, and severe non-neurological morbidity by type of placental abnormality. This was a prospective cohort study
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Obstetric and neonatal outcomes in pregnancies complicated by placental abruption with vs. without supporting sonographic findings- A retrospective cohort study Placenta (IF 3.0) Pub Date : 2024-08-30 Liat Mor, Naama Erteschik, Erika Gandelsman, Anna Vartkova, Ilia Kleiner, Giulia Barda, Liat Gindes, Letizia Schreiber, Eran Weiner, Noa Gonen
Placental abruption (PA) is a major obstetric complication associated with worse maternal and neonatal outcomes. Though ultrasound findings may support the diagnosis of PA, the association of such findings to the severity of PA and maternal and neonatal outcomes is not yet clear. We aimed to assess the maternal and neonatal outcomes of PA cases with vs. without related sonographic findings. In this
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Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is reduced with preeclampsia and small for gestational aged fetuses Placenta (IF 3.0) Pub Date : 2024-08-29 Lucy A. Bartho, Susan P. Walker, Ping Cannon, Tuong-Vi Nguyen, Anna Nguyen, Stefan M. Botha, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) is an inhibitory receptor expressed on immune cells. We evaluated LAIR1 in placentas from preeclamptic or small for gestational age (SGA) pregnancies, and placental explant model (1 % O, IL6 and TNFα, or control). mRNA was reduced in placentas from preeclamptic (p < 0.0001, n = 78) and SGA (p < 0.0001, n = 32) pregnancies. LAIR1 protein expression
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Long-term culture and passaging of term trophoblast for the investigation of syncytiotrophoblast function Placenta (IF 3.0) Pub Date : 2024-08-28 Alice Hawkins, Paschalia Pantazi, Liheng Yang, Carolyn B. Coyne, Vladimir Bokun, Jose M. Lemme-Dumit, Marcela F. Pasetti, Sara Barnett, Fiona J. Culley, Beth Holder
Recent advances in the use of trophoblast stem cells and organoid models have markedly enhanced our understanding of placental development and function. These models offer significant improvements over previous systems due to their extended viability in culture and capacity to replicate various trophoblast functions, such as extravillous trophoblast invasion, syncytialisation and 3D architecture. Initially
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Preeclampsia - A patient's perspective Placenta (IF 3.0) Pub Date : 2024-08-24 D. Mark, J.L. James
The opening session of the 2023 International Federation of Placenta Associations meeting included a powerful patient perspective from invited guest Dawn Mark about her experience with preeclampsia and stillbirth. As part of this issue of Trophoblast Research we invited Dawn to provide this in written form, to more widely share her important message. Her children's names have been changed to protect
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Docosahexaenoic acid insufficiency impairs placental angiogenesis by repressing the methylene-bridge fatty acylation of AKT in preeclampsia Placenta (IF 3.0) Pub Date : 2024-08-22 Lidong Liu, Huanqiang Zhao, Yinan Wang, Yutong Cui, Huiqing Lu, Yu Xiong, Xirong Xiao, Qiongjie Zhou, Yiyuan Yuan, Shimin Zhao, Xiaotian Li
Preeclampsia (PE), characterised by hypertension in pregnancy, is regarded as a placental metabolism-related syndrome affecting 5–8% of pregnancies worldwide. The insufficiency of polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA), is a causative factor of PE pathogenesis. However, its molecular aetiology is yet to be comprehensively elucidated. CRISPR/Cas9 was used to construct
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High expression of CX3CL1/CX3CR1 at the mother-fetus interface of preeclampsia inhibits trophoblast invasion and migration Placenta (IF 3.0) Pub Date : 2024-08-21 Haixia Liu, Ping Wang, Junbin Yin, Ping Yang, Jingjing Shi, Aihua Li, Xietong Wang, Jinlai Meng
Preeclampsia is associated with maternal inflammatory overreaction and imbalanced immunity at the mother-fetus interface. The pro-inflammatory chemokine fractalkine (CX3CL1) is recently recognized apart from imbalanced immunity. In this study, CX3CL1- CX3C chemokine receptor 1(CX3CR1) regulation of decidual macrophage function and trophoblast invasion ability in preeclampsia was initially explored
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Prevalence of placental bed spiral artery pathology in preeclampsia and fetal growth restriction: A prospective cohort study Placenta (IF 3.0) Pub Date : 2024-08-20 Laura Brouwers, Steffie de Gier, Tatjana E. Vogelvang, Jan H.W. Veerbeek, Arie Franx, Bas B. van Rijn, Peter G.J. Nikkels
Preeclampsia and fetal growth restriction (PE/FGR) are pregnancy complications known to be associated with poor utero-placental function due to abnormal “physiological” remodeling of spiral arteries and unfavorable maternal cardiovascular health. However, the prevalence and degree of impaired spiral artery remodeling has not been clearly established. Prospective, multi-center observational cohort study
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ASPG and DAD1 are potential placental-derived biomarkers for ASD-like symptom severity levels in male/female offspring Placenta (IF 3.0) Pub Date : 2024-08-14 Yi-Xiao Wu, Ming-Jie Li, Yue Liu, Min Guo, Meng-Ning Lan, Hua-Jun Zheng
An early evaluating system for autism spectrum disorder (ASD) severity is crucial. Questionnaire survey is challenging for accurately assessing the severity levels for ASD in children. Offspring with ASD-like phenotypes were induced by treating pregnant mice with Poly (I:C) at GD12.5 and the placentae corresponding to the offspring were obtained by caesarean. The autism severity composite score (ASCS)
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Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy Placenta (IF 3.0) Pub Date : 2024-08-13 Kelsey L. Swingle, Alex G. Hamilton, Michael J. Mitchell
Clinically approved therapeutics for obstetric conditions are extremely limited, with over 80% of drugs lacking appropriate labeling information for pregnant individuals. The pathology for many of these obstetric conditions can be linked to the placenta, necessitating the development of therapeutic platforms for selective drug delivery to the placenta. When evaluating therapeutics for placental delivery
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Hydroquinone impairs trophoblast migration and invasion via AHR-twist-IFITM1 axis Placenta (IF 3.0) Pub Date : 2024-08-10 Anthony Maxwell, Grace Swanson, Annie Thy Nguyen, Anna Hu, Darby Richards, Yuan You, Laura Stephan, Marcia Manaloto, Aihua Liao, Jiahui Ding, Gil Mor
Embryo implantation is a tightly regulated process, critical for a successful pregnancy. After attachment of the blastocyst to the surface epithelium of the endometrium trophoblast migrate from the trophectoderm and invade into the stromal component of endometrium. Alterations on either process will lead to implantation failure or miscarriage. Volatile organic compounds (VOCs) such as benzene induce
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Bioengineering approaches for patient-specific analysis of placenta structure and function Placenta (IF 3.0) Pub Date : 2024-08-08 Adrienne K. Scott, Daniella M. Fodera, Patrick Yang, Abigail Arter, Amelia M. Hines, Samyuktha S. Kolluru, Samantha G. Zambuto, Kristin M. Myers, Ulugbek S. Kamilov, Anthony O. Odibo, Michelle L. Oyen
The leading cause of perinatal mortality is fetal growth restriction (FGR), defined as fetal growth below the 10th percentile. Insufficient exchange of oxygen and nutrients at the maternal-fetal interface is associated with FGR. This transport occurs through the vasculature of the placenta, particularly in the terminal villi, where the vascular membranes have a large surface area and are the thinnest
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Magnetic resonance imaging diagnosis of abnormal placental cord insertions Placenta (IF 3.0) Pub Date : 2024-08-08 Gan Tian, Xiaochao Fang, Fengying Chen, Pin Wang, Yunya Lu, Ying Zhang, Yunsi Liang, Haojie Ning, Donghua Zhou, Dawei Zhang, Xiangliang Tan
Abnormal placental cord insertions (APCIs) are significant risk factors for pregnancy complications, encompassing marginal cord insertion (MCI), velamentous cord insertion (VCI), and vasa previa (VP). While ultrasound is the primary imaging modality, its accuracy can be limited by factors such as maternal obesity and fetal positioning. Complementary to ultrasound, magnetic resonance imaging (MRI) offers
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MicroRNA expression profile in the basal plate of human placenta associates with spontaneous preterm birth Placenta (IF 3.0) Pub Date : 2024-08-06 Heli Tiensuu, Antti M. Haapalainen, Pinja Tissarinen, Anu Pasanen, Mikko Hallman, Mika Rämet
MicroRNAs regulate post-transcriptional gene expression. Their expression has been linked to many pregnancy complications, including preterm birth. Placental microRNA levels differ between preterm and term pregnancies. Not much is known about the targets that are affected by these differences in microRNA expression. We investigated associations between microRNA expression levels in the basal plate
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Comprehensive microarray analysis of severe preeclampsia placenta to identify differentially expressed genes, biological pathways, hub genes, and their related non-coding RNAs Placenta (IF 3.0) Pub Date : 2024-08-06 Maedeh Shabani, Maryam Eghbali, Ameneh Abiri, Maryam Abiri
Preeclampsia (PE) is a serious pregnancy-related complication caused by high blood pressure in pregnant women. The severe form has more devastating effects. According to the growing evidence, the placenta is a crucial component in the pathogenesis of PE, and eliminating it will alleviate symptoms. GEO's severe preeclampsia placenta microarray datasets; GSE147776, GSE66273, GSE102897, and GSE10588,
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Relevance of the regulation of the brain-placental axis to the nocturnal bottleneck of mammals Placenta (IF 3.0) Pub Date : 2024-08-06 Shankar P. Poudel, Susanta K. Behura
Evolutionary theory suggests that the ancestors of all placental animals were nocturnal. Visual perceptive function of mammalian brain has evolved extensively, but nearly 70 % of today's mammals are still nocturnal. While placental influence on brain development is known, if placenta plays a role in the visual perceptive function of mammalian brain remains untested. The present study aims to test this
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Krüppel-like factor 6 involvement in the endoplasmic reticulum homeostasis of extravillous trophoblasts Placenta (IF 3.0) Pub Date : 2024-08-05 Lucille T. Kourdova, Andrea L. Miranda, Milagros Ovejero, Agustín Anastasía, Susana Genti-Raimondi, Ana C. Racca, Graciela M. Panzetta-Dutari
Trophoblast homeostasis and differentiation require a proper endoplasmic reticulum (ER) function. The Krüppel-like factor-6 (KLF6) transcription factor modulates trophoblast migration, differentiation, and reactive oxygen species (ROS) production. Since ROS may impact on ER homeostasis, we assessed whether downregulation of KLF6 altered the unfolded protein response (UPR) and cellular process associated
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Characterizing placental pericytes: Hypoxia and proangiogenic signalling Placenta (IF 3.0) Pub Date : 2024-08-02 Megan J. Morrison, Bryony V. Natale, Sofia Allen, Nichole Peterson, David R.C. Natale
Pericytes wrap microvessels and interact with endothelial cells to regulate vascular growth. Though pericyte dropout has been reported in pathological human placentae and mouse models of placental pathology, there has been limited investigation of the role and function of placental pericytes in vascular health and pathology. This study aimed to investigate the angiogenic potential of human placental
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Correlative three-dimensional X-ray histology (3D-XRH) as a tool for quantifying mammalian placental structure Placenta (IF 3.0) Pub Date : 2024-07-31 Davis Laundon, Thomas Lane, Orestis L. Katsamenis, Jeanette Norman, Lois Brewer, Shelley E. Harris, Philip J. Basford, Justine Shotton, Danielle Free, Georgina Constable-Dakeyne, Neil J. Gostling, Pascale Chavatte-Palmer, Rohan M. Lewis
Mammalian placentas exhibit unparalleled structural diversity, despite sharing a common ancestor and principal functions. The bulk of structural studies in placental research has used two-dimensional (2D) histology sectioning, allowing significant advances in our understanding of mammalian placental structure. However, 2D histology sectioning may be limited if it does not provide accurate information
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Quantitative microCT imaging of a whole equine placenta and its blood vessel network Placenta (IF 3.0) Pub Date : 2024-07-31 Davis Laundon, Ella Proudley, Philip J. Basford, Orestis L. Katsamenis, David S. Chatelet, Jane K. Cleal, Neil J. Gostling, Pascale Chavatte-Palmer, Rohan M. Lewis
Placental structure is linked to function across morphological scales. In the placenta, changes to gross anatomy, such as surface area, volume, or blood vessel arrangement, are associated with suboptimal physiological outcomes. However, quantifying each of these metrics requires different laborious semi-quantitative methods. Here, we demonstrate how, with minimal sample preparation, whole-organ computed
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Multi-type maternal diabetes mellitus affects human placental villous geometric morphology: A three-dimensional imaging study Placenta (IF 3.0) Pub Date : 2024-07-30 Xuemei Gao, Xiaoyang Qin, Shaoyu Pei, Wenjing Wang, Renxiong Wu, Jie Mei, Yong Liu, Yao Xie, Guangming Ni
Diabetes mellitus leads to maldevelopment of the villous morphology in the human placenta, disrupting the exchange of materials between the maternal and fetal compartments, consequently compromising fetal development. This study aims to explore how different types of diabetes mellitus affect human placental villous geometric morphology including branching numbers and sizes (length, diameter). Here
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Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia Placenta (IF 3.0) Pub Date : 2024-07-29 Ya-Nan Wang, Xue-Ling Chen, Ju Yang, Xing-Xing Gong, Hai-Feng Zhang, Yan-Mei Zhang, Dan-Feng Zeng, Pei-Shan Chen, Hai-Bin Chen
Preeclampsia is a pregnancy-specific disorder characterized by de novo development of hypertension and proteinuria over 20 weeks gestation that has been associated with the dysfunction of trophoblasts. Current evidence suggests that syncytin-1 plays an important role in the non-fusogenic biological activity of trophoblasts, except for specific fusogenic function. However, the underlying mechanism remains
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Transcriptional insights from the human embryo identify laminin-511 as a suitable matrix for human trophoblast stem cell culture Placenta (IF 3.0) Pub Date : 2024-07-26 Nathaly Hernández-Díaz, Sofia Tzouganatou, Praditi R. Mulik, Paula A. Balestrini, Norah M.E. Fogarty
The establishment of culture conditions to propagate self-renewing human trophoblast stem cells in long-term culture provides a paradigm for modelling of trophoblast. The extracellular matrix (ECM) is a critical determinant of cell identity and behaviour. Therefore, models aiming to reproduce cells should recapitulate the native cell-ECM microenvironment. Here, we mine human embryo transcriptional
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Association between trimester-specific prenatal air pollution exposure and placental weight of twins Placenta (IF 3.0) Pub Date : 2024-07-26 Simone Teresa Böhm-González, Alischa Ziemendorff, Eline Meireson, Steven Weyers, Tim Nawrot, Esmée Bijnens, Marij Gielen
This study investigates the association between maternal exposure to particulate matter (PM) and nitric dioxide (NO) during the first, second and third trimester and placental weight and birth weight/placental weight (BW/PW) ratio in twins at birth. Cross-sectional data of 3340 twins from the East Flanders Prospective Twin Survey was used. Air pollutant exposure was estimated via spatial temporal interpolation
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Isolation of pure primary term human cytotrophoblasts and their differentiation into syncytiotrophoblast-like cells as an ex vivo model of the human placenta Placenta (IF 3.0) Pub Date : 2024-07-24 Kenichiro Motomura, Hideaki Morita, Hiromichi Yamamoto, Seiji Wada, Haruhiko Sago, Hironori Takahashi, Hirohisa Saito, Kenji Matsumoto
The placenta plays a fundamental role in fetal growth and maintenance of pregnancy. Its cellular components include a large multinucleated syncytiotrophoblast (STB) and its progenitor, cytotrophoblasts (CTBs), both of which perform vital functions in the human placenta. Primary cytotrophoblasts isolated from term human placentas that spontaneously fuse and differentiate into syncytiotrophoblast-like
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Identification of divergent placental profiles in clinically distinct pregnancy complications revealed by the transcriptome Placenta (IF 3.0) Pub Date : 2024-07-22 Camille Couture, Maxime Caron, Pascal St-Onge, Marie-Eve Brien, Daniel Sinnett, Dorothée Dal Soglio, Sylvie Girard
Pregnancy complications, including preeclampsia (PE), preterm birth (PTB), and intra-uterine growth restriction (IUGR) have individually been associated with inflammation but the combined comparative analysis of their placental profiles at the transcriptomic and histological levels is lacking. Bulk RNA-sequencing of human placental biopsies from uncomplicated term pregnancies (CTL) and pregnancies
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Unveiling the placental secrets: Exploring histopathological changes and TROP2 expression in intrahepatic cholestasis of pregnancy Placenta (IF 3.0) Pub Date : 2024-07-20 Cezmi Baran Ozalp, Sozdar Akdogan, Dilan Cetinavci, Melike Nur Akin, Hulya Elbe, Burcu Kasap
Gestational cholestasis, also known as intrahepatic cholestasis of pregnancy (ICP) or obstetric cholestasis, is a liver disease that can manifest in late pregnancy. Trophoblast cell surface antigen (TROP2) is a type I transmembrane glycoprotein identified in placental trophoblast cells that plays a critical role in trophoblast invasion of the decidua upon implantation into the placenta. Our study aims
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Relation between possible under-diagnosed/treated glucose dysmetabolism, delayed villous maturation, and lethal fetal pneumonia Placenta (IF 3.0) Pub Date : 2024-07-20 M. Petrovic, E. Savvoulidou, S. Johnson, C. Battaglino, I. Bourne, M. Whitten, D. Siassakos
Gestational diabetes mellitus (GDM) is a known risk factor for stillbirth (Rosenstein et al., 2012) [1]. Delayed villous maturation (DVM), predominantly seen in term placentas in pregnancies complicated with glucose dysmetabolism, may in part be a consequence of excessive maternal glucose leading to release of fetal insulin and other growth factors that promote excessive placental growth at the expense
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A quantitative image analysis platform for assessing trophoblast differentiation Placenta (IF 3.0) Pub Date : 2024-07-18 Mahe Jabeen, Victoria Karakis, John Britt, Adriana San Miguel, Balaji Rao
Immunofluorescence microscopy is extensively used in characterization of trophoblast differentiation in vitro. However, such data is primarily used to confirm the presence of protein markers or qualitatively compare levels of protein markers across experimental conditions. Imaging data, when processed and analyzed appropriately can provide quantitative and spatial information, and provide biological
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MRI assessed placental volume and adverse pregnancy outcomes: Secondary analysis of prospective cohort study Placenta (IF 3.0) Pub Date : 2024-07-14 Karen J. Gibbins, Victoria H.J. Roberts, Jamie O. Lo, Emily R. Boniface, Matthias C. Schabel, Robert M. Silver, Antonio E. Frias
Our goal was to evaluate the potential utility of magnetic resonance imaging (MRI) placental volume as an assessment of placental insufficiency. Secondary analysis of a prospective cohort undergoing serial placental MRIs at two academic tertiary care centers. The population included 316 participants undergoing MRI up to three times throughout gestation. MRI was used to calculate placental volume in
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Lower ERVW-1 and higher VEGF, FLT-1 and HIF-1 gene expression in placentae of low birth babies from Indonesia Placenta (IF 3.0) Pub Date : 2024-07-14 Teresa Nurtanio, Bilqis Zahra Nabila, Jajah Fachiroh, Neti Nuraini, Dewajani Purnomosari
Poor placental angiogenesis is associated with several pregnancy complications including fetal growth restriction (FGR), which causes low birth weight (LBW) babies to have a high risk of growth disorders and metabolic disorders in adulthood. Recent research using syncytin knock-out mice showed significant disruption in the growth of placental vascularization. Syncytin-1 which encoded by gene, is proposed
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Unlocking the secrets of Hofbauer cells in placental (patho-) physiology: Isolation and quality assessment in human term placenta Placenta (IF 3.0) Pub Date : 2024-07-10 Monika Horvat Mercnik, Christian Wadsack, Carolin Schliefsteiner
Hofbauer cells (HBCs) are macrophages of fetal origin that reside in the villous tissue. They are the only immune cells within healthy villi. While HBCs perform innate immune functions such as phagocytosis and antigen presentation, they are increasingly recognized for their diverse roles in placental physiology e.g. vascular functionality, tissue homeostasis, tolerance. Consequently, HBCs are of utmost
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Optimized CRISPR-based knockout in BeWo cells Placenta (IF 3.0) Pub Date : 2024-07-08 Eric Yin, Meagan N. Esbin
CRISPR genome editing is a widely used tool to perturb genes of interest within cells and tissues and can be used as a research tool to study the connection between genotypes and cellular phenotypes. Highly efficient genome editing is limited in certain cell types due to low transfection efficiency or single-cell survivability. This is true for BeWo cells, an model of placental syncytiotrophoblast
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Placental biophysical model for prediction of early onset fetal growth restriction in first and second trimester of pregnancy: A prospective cohort study Placenta (IF 3.0) Pub Date : 2024-07-04 Manisha Kumar, Kirti Balyan, Ekta Debnath, Ben Humtsoe, Bhawana Meena, V. Ravi, Shalini Singh
To assess the placental biometry, placental biomarkers and uterine artery Doppler in each trimester of pregnancy for prediction of early-onset fetal growth restriction (EO FGR). In this prospective cohort study placental biometry; biomarkers PAPP-A, sFLT-1, and PlGF along with the uterine artery blood flow evaluation was done serially at 11–14, 20–24 and 28–32 weeks of gestation. The above parameters
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Effects of different PCOS phenotypes on placental three-dimensional power Doppler indices and placental volume during the first trimester Placenta (IF 3.0) Pub Date : 2024-07-03 Erdem Sahin, Mefkure Eraslan Sahin, Mehmet Mete Kirlangic, Serhan Kutuk, Seyma Daglıtuncezdi Cam, Havva Can Ozdemir, Emre Genc
The aim of the present study was to evaluate the effects of different polycystic ovary syndrome (PCOS) phenotypes using first-trimester placental three-dimensional power Doppler indices and placental volume. In this prospective case-control study, 170 pregnant women who met the inclusion criteria were divided into five groups according to PCOS phenotype: non-PCOS control ( = 34), PCOS phenotype A ( = 34)
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Placental chronic inflammatory histopathology and fetal growth in a cohort with universal placental examination Placenta (IF 3.0) Pub Date : 2024-07-02 Carolyn M. Salafia, Caitlin Rukat, Beata Dygulska, Richard K. Miller, Dawn P. Misra
Chronic placental inflammation is a routinely diagnosed group of placental lesions that reflect immunologic dysfunction of the mother, fetus, or both. Complete placental pathology examinations were performed for all term births at New York Presbyterian- Brooklyn Methodist Hospital from January 2010–August 2016. Diagnoses were blinded except to gestational age. CPI lesions were marked as chronic choriodeciduitis
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Fibroblasts activation by embryonic signal switching: A novel mechanism of placental growth factor-induced cardiac remodeling Placenta (IF 3.0) Pub Date : 2024-07-02 Lisa Kitasato, Minako Yamaoka-Tojo, Machika Suzuki, Shohei Nakahara, Toshiyuki Iwaya, Sho Ogiso, Yusuke Murayama, Takehiro Hashikata, Nonoka Misawa, Rei Kawashima, Jun Oikawa, Masaki Nakamura, Yumi Tokui, Jun Naraba, Mototsugu Nishii, Hidero Kitasato, Junya Ako
Cardiac remodeling is defined as cellular interstitial changes that lead dysfunction of the heart after injury. Placental growth factor (PlGF), a member of the VEGF family, has been reported to regulate cardiac hypertrophy in hemodynamic state. PlGF overexpressed mouse embryonic fibroblasts derived from C57BL/6 mice, were made by deficient retrovirus vector, designated as C57/PlGF. Only retrovirus
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Criteria and non-criteria antiphospholipid autoantibodies screening in patients with late pregnancy morbidity: A cross-sectional study Placenta (IF 3.0) Pub Date : 2024-06-29 Clothilde Gros, Arthur Mageau, Tiphaine Barral, Pascale Roland Nicaise, Marie-Hélène Saint-Frison, Margot Bucau, Valérie Vivier, Valentine Marie Ferre, Agnès Bourgeois-Moine, Thomas Papo, Tiphaine Goulenok, Karim Sacre
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Reply to Van Gemert et al.: Towards a future of placental research with deep-learning models Placenta (IF 3.0) Pub Date : 2024-06-28 A.T.R. Noll, L.E. Van der Meeren, E.J.T. Verweij, L. Lewi
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Inhibitory effect of all-trans retinoic acid on ferroptosis in BeWo cells mediated by the upregulation of heme Oxygenase-1 Placenta (IF 3.0) Pub Date : 2024-06-24 Tomona Matsuoka, Kazuhiro Kajiwara, Tomoyuki Kawasaki, Seiji Wada, Osamu Samura, Haruhiko Sago, Aikou Okamoto, Akihiro Umezawa, Hidenori Akutsu
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Oxidative stress biomarkers for fetal growth restriction in umbilical cord blood: A scoping review Placenta (IF 3.0) Pub Date : 2024-06-24 Evelien L. Blok, Renée J. Burger, Jenny E.Van Bergeijk, Arno R. Bourgonje, Harry Van Goor, Wessel Ganzevoort, Sanne J. Gordijn
Fetal growth restriction and underlying placental insufficiency are associated with increased oxidative stress. Current diagnostics fail to identify all growth restricted fetuses and newborns, due to focus on small size. This scoping review aims to summarize the available evidence on usefulness of cord blood oxidative stress biomarkers for identification of growth restricted newborns in need of monitoring
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Placental somatic mutation in human stillbirth and live birth: A pilot case-control study of paired placental, fetal, and maternal whole genomes Placenta (IF 3.0) Pub Date : 2024-06-22 Amelia D. Wallace, Nathan R. Blue, Terry Morgan, Tsegaselassie Workalemahu, Robert M. Silver, Aaron R. Quinlan
A high frequency of single nucleotide somatic mutations in the placenta has been recently described, but its relationship to placental dysfunction is unknown. We performed a pilot case-control study using paired fetal, maternal, and placental samples collected from healthy live birth controls (n = 10), live births with fetal growth restriction (FGR) due to placental insufficiency (n = 7), and stillbirths
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Mammalian placental explants: A tool for studying host-parasite interactions and placental biology Placenta (IF 3.0) Pub Date : 2024-06-19 Christian Castillo, Cintia Díaz-Luján, Ana Liempi, Ricardo Fretes, Ulrike Kemmerling
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Is the rabbit a natural model of fetal growth restriction? Morphological and functional characterization study using diffusion-weighted MRI and stereology Placenta (IF 3.0) Pub Date : 2024-06-19 Matthieu Dap, Théo Albert, Ikrame Ramdhani, Anne Couturier-Tarrade, Olivier Morel, Pascale Chavatte-Palmer, Marine Beaumont, Charline Bertholdt
Rabbits are routinely used as a natural model of fetal growth restriction (FGR); however, no studies have confirmed that rabbits have FGR. This study aimed to characterize the fetoplacental unit (FPU) in healthy pregnant rabbits using diffusion-weighted MRI and stereology. A secondary objective of the study was to describe the associations among findings from diffusion-weighted MRI (DW-MRI), fetal
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Immunohistochemical localization of HCA1 receptor in placenta in presence of fetal growth restriction Placenta (IF 3.0) Pub Date : 2024-06-19 Ayumi Kozai, Ryuta Murakami, Yoichi Chiba, Yumi Miyai, Koichi Matsumoto, Kenji Kanenishi, Masaki Ueno
Glucose metabolism produces lactate and hydrogen ions in an anaerobic environment. Fetuses with intrauterine growth restriction are considered to become progressively lactacidemic as well as hypoxic. Roles of lactate in the placenta in the presence of fetal growth restriction (FGR) remain to be clarified. Immunohistochemical localization of lactate-related substances, such as a receptor for lactate
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Circ_0007611 modulates the miR-34c-5p/LPAR2 cascade to suppress proliferation and enhance apoptosis of HTR-8/SVneo cells Placenta (IF 3.0) Pub Date : 2024-06-18 Meiyu Song, Qian Yan, Ronghui Liu
The aberrant biological behaviors of trophoblast cells actively take part in the pathogenesis of preeclampsia (PE). Herein, we defined the action of the circular RNA (circRNA) circ_0007611 on trophoblast cell apoptosis and growth to understand its role in PE. Expression of circ_0007611, miR-34c-5p and lysophosphatidic acid receptor 2 (LPAR2) mRNA was analyzed by qPCR. LPAR2 protein was determined by
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Homeobox genes in the human placenta: Twists and turns on the path to find novel targets Placenta (IF 3.0) Pub Date : 2024-06-18 Padma Murthi, Bill Kalionis
Fetal growth restriction (FGR) is a clinically important human pregnancy disorder that is thought to originate early in pregnancy and while its aetiology is not well understood, the disorder is associated with placental insufficiency. Currently treatment for FGR is limited by increased surveillance using ultrasound monitoring and premature delivery, or corticosteroid medication in the third trimester
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Small RNAs in the pathogenesis of preeclampsia Placenta (IF 3.0) Pub Date : 2024-06-17 William R. Cooke, Gabriel Davis Jones, Christopher WG. Redman, Manu Vatish
Preeclampsia is a major contributor to maternal and fetal morbidity and mortality. The disorder can be classified into early- and late-onset subtypes, both of which evolve in two stages. The first stage comprises the development of pre-clinical, utero-placental malperfusion. Early and late utero-placental malperfusion have different causes and time courses. Early-onset preeclampsia (20 % of cases)
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Confined placental mosaicism: Distribution of chromosomally abnormal cells over the term placenta Placenta (IF 3.0) Pub Date : 2024-06-15 G.M. Eggenhuizen, S. van Veen, N. van Koetsveld, A.T.J.I. Go, K.E.M. Diderich, M. Joosten, M. van den Born, M.I. Srebniak, D. Van Opstal
Non-invasive prenatal testing (NIPT) investigates placental DNA and may detect confined placental mosaicism (CPM). The aim of this study was to confirm CPM in the term placenta in cases with abnormal NIPT but normal follow-up cytogenetic studies of fetus and mother. Additionally we examined the distribution of abnormal cells over the placenta. Four chorionic villus (CV) biopsies from four placental
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Fluorescence-activated nuclear sorting (FANS) of nuclei from in vitro-generated syncytiotrophoblast Placenta (IF 3.0) Pub Date : 2024-06-13 Teka Khan, Jeffrey J. Whyte, Laura C. Schulz, R. Michael Roberts
Large, multinucleated cells, like syncytiotrophoblasts (STB), are not readily analyzed by standard methods used for single cells, such as single-cell RNA-sequencing and fluorescence-activated cellular sorting (FACS). Here we have demonstrated that fluorescence-activated nuclear sorting (FANS) is suitable to analyze nuclei from STB. Human pluripotent stem cells (PSCs) can be differentiated into a mixed
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Step-by-step protocol for isolating the entire repertoire of human first trimester placental cells Placenta (IF 3.0) Pub Date : 2024-06-13 Theresa Maxian, Anna-Maria Prandstetter, Hanna Waldhäusl, Anna-Lena Höbler, Gudrun Meinhardt, Jasmin Wächter, Jürgen Pollheimer, Martin Knöfler, Sandra Haider
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Comparative proteomics analysis of decidua reveals altered RNA processing and impaired ribosome function in recurrent pregnancy loss Placenta (IF 3.0) Pub Date : 2024-06-08 Katarina Davalieva, Marija Terzikj, Gjorgji Bozhinovski, Sanja Kiprijanovska, Katerina Kubelka-Sabit, Dijana Plaseska-Karanfilska
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Unravelling the oxygen factor - An investigation of transcriptional activation of hypoxia associated placental angiogenesis in recurrent pregnancy loss (RPL) patients from Assam, India Placenta (IF 3.0) Pub Date : 2024-06-07 N. Kashyap, C.R. Das, R. Datta, A. Begum, M. Islam, S. Bose, P.D. Bose
Recurrent pregnancy loss (RPL) is defined as the spontaneous loss of two or more consecutive pregnancies before 20 weeks of gestation, and affects 7.46 % of the Indian population. About 40–50 % of RPL cases are idiopathic making it a therapeutic challenge for clinicians. This study focuses on elucidating the role of hypoxia-associated placental angiogenesis in these idiopathic RPL cases. Whole blood
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Characterisation of ciclesonide metabolism in human placentae across gestation Placenta (IF 3.0) Pub Date : 2024-06-04 Ashley S. Meakin, Kathryn L. Gatford, Yu-Chin Lien, Michael D. Wiese, Rebecca A. Simmons, Janna L. Morrison
Current clinical management of pregnancies at risk of preterm delivery includes maternal antenatal corticosteroid (ACS) treatment. ACS activate the glucocorticoid receptor (GR) in all fetal tissues, maturing the lungs at the cost of impaired brain development, creating a need for novel treatments. The prodrug ciclesonide (CIC) activates the GR only when converted to des-CIC by specific enzymes, including