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Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo Malaria J. (IF 3.0) Pub Date : 2024-03-18 Nadine Kalenda Kayiba, Yuko Nitahara, Evariste Tshibangu-Kabamba, Denis Kalambayi Mbuyi, Augustin Kabongo-Tshibaka, Nestor Tshituka Kalala, Barthélemy Mukenga Tshiebue, Katherine-Sofia Candray-Medina, Natsuko Kaku, Yu Nakagama, Niko Speybroeck, Dieudonné Ngoyi Mumba, Ghislain Tumba Disashi, Akira Kaneko, Yasutoshi Kido
Adults infected with Plasmodium spp. in endemic areas need to be re-evaluated in light of global malaria elimination goals. They potentially undermine malaria interventions but remain an overlooked aspect of public health strategies. This study aimed to estimate the prevalence of Plasmodium spp. infections, to identify underlying parasite species, and to assess predicting factors among adults residing
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Comparison of different trapping methods to collect malaria vectors indoors and outdoors in western Kenya Malaria J. (IF 3.0) Pub Date : 2024-03-16 Jackline Kosgei, John E. Gimnig, Vincent Moshi, Seline Omondi, Daniel P. McDermott, Martin J. Donnelly, Collins Ouma, Bernard Abong’o, Eric Ochomo
Vector surveillance is among the World Health Organization global vector control response (2017–2030) pillars. Human landing catches are a gold standard but difficult to implement and potentially expose collectors to malaria infection. Other methods like light traps, pyrethrum spray catches and aspiration are less expensive and less risky to collectors. Three mosquito sampling methods (UV light traps
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Cost effectiveness of malaria vector control activities in Sudan Malaria J. (IF 3.0) Pub Date : 2024-03-15 Sami M. HasapAla, Rasha S. Azrag, Osama M. Awad
Malaria vector control activities in Sudan rely largely on Long-Lasting Insecticidal Nets (LLINs), Indoor Residual Spray (IRS) and Larval Source Management (LSM). The present study attempted to determine cost effectiveness of inputs and operations of vector control interventions applied in different environmental settings in central and eastern Sudan, as well as their impact. The inputs utilized and
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Microsatellites reveal high polymorphism and high potential for use in anti-malarial efficacy studies in areas with different transmission intensities in mainland Tanzania Malaria J. (IF 3.0) Pub Date : 2024-03-15 Deus S. Ishengoma, Celine I. Mandara, Rashid A. Madebe, Marian Warsame, Billy Ngasala, Abdunoor M. Kabanywanyi, Muhidin K. Mahende, Erasmus Kamugisha, Reginald A. Kavishe, Florida Muro, Renata Mandike, Sigsbert Mkude, Frank Chacky, Ritha Njau, Troy Martin, Ally Mohamed, Jeffrey A. Bailey, Abebe A. Fola
Tanzania is currently implementing therapeutic efficacy studies (TES) in areas of varying malaria transmission intensities as per the World Health Organization (WHO) recommendations. In TES, distinguishing reinfection from recrudescence is critical for the determination of anti-malarial efficacy. Recently, the WHO recommended genotyping polymorphic coding genes, merozoite surface proteins 1 and 2 (msp1
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Application of advanced very high-resolution radiometer (AVHRR)-based vegetation health indices for modelling and predicting malaria in Northern Benin, West Africa Malaria J. (IF 3.0) Pub Date : 2024-03-15 Gouvidé Jean Gbaguidi, Mouhamed Idrissou, Nikita Topanou, Walter Leal Filho, Guillaume K. Ketoh
Vegetation health (VH) is a powerful characteristic for forecasting malaria incidence in regions where the disease is prevalent. This study aims to determine how vegetation health affects the prevalence of malaria and create seasonal weather forecasts using NOAA/AVHRR environmental satellite data that can be substituted for malaria epidemic forecasts. Weekly advanced very high-resolution radiometer
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Insecticide susceptibility status of Anopheles gambiae mosquitoes and the effect of pre-exposure to a piperonyl butoxide (PBO) synergist on resistance to deltamethrin in northern Namibia Malaria J. (IF 3.0) Pub Date : 2024-03-14 Rosalia N. Joseph, Tabeth Mwema, Seth J. Eiseb, Deodatus V. Maliti, Munyaradzi Tambo, Iitula Iitula, Lydia Eloff, Ophilia Lukubwe, Cara Smith-Gueye, Élodie A. Vajda, Allison Tatarsky, Stark T. Katokele, Petrina N. Uusiku, Dennis Walusimbi, Sheila B. Ogoma, Davis R. Mumbengegwi, Neil F. Lobo
Pyrethroid-based indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) have been employed as key vector control measures against malaria in Namibia. However, pyrethroid resistance in Anopheles mosquitoes may compromise the efficacy of these interventions. To address this challenge, the World Health Organization (WHO) recommends the use of piperonyl butoxide (PBO) LLINs in areas
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Epidemiology of Plasmodium vivax in Duffy negatives and Duffy positives from community and health centre collections in Ethiopia Malaria J. (IF 3.0) Pub Date : 2024-03-14 Lauren Bradley, Delenasaw Yewhalaw, Elizabeth Hemming-Schroeder, Brook Jeang, Ming-Chieh Lee, Endalew Zemene, Teshome Degefa, Eugenia Lo, Christopher King, James Kazura, Guiyun Yan
Malaria remains a significant cause of morbidity and mortality in Ethiopia with an estimated 3.8 million cases in 2021 and 61% of the population living in areas at risk of malaria transmission. Throughout the country Plasmodium vivax and Plasmodium falciparum are co-endemic, and Duffy expression is highly heterogeneous. The public health significance of Duffy negativity in relation to P. vivax malaria
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Comparing malaria risk exposure in rural Cambodia population using GPS tracking and questionnaires Malaria J. (IF 3.0) Pub Date : 2024-03-12 Anaïs Pepey, Marc Souris, Saorin Kim, Thomas Obadia, Sophy Chy, Malen Ea, Sivkeng Ouk, Franck Remoue, Siv Sovannaroth, Ivo Mueller, Benoit Witkowski, Amélie Vantaux
The Great Mekong Subregion has attained a major decline in malaria cases and fatalities over the last years, but residual transmission hotspots remain, supposedly fueled by forest workers and migrant populations. This study aimed to: (i) characterize the fine-scale mobility of forest-goers and understand links between their daily movement patterns and malaria transmission, using parasites detection
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Malaria transmission heterogeneity in different eco-epidemiological areas of western Kenya: a region-wide observational and risk classification study for adaptive intervention planning Malaria J. (IF 3.0) Pub Date : 2024-03-12 Guofa Zhou, John Githure, Ming-Chieh Lee, Daibin Zhong, Xiaoming Wang, Harrysone Atieli, Andrew K. Githeko, James Kazura, Guiyun Yan
Understanding of malaria ecology is a prerequisite for designing locally adapted control strategies in resource-limited settings. The aim of this study was to utilize the spatial heterogeneity in malaria transmission for the designing of adaptive interventions. Field collections of clinical malaria incidence, asymptomatic Plasmodium infection, and malaria vector data were conducted from 108 randomly
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Factors affecting delays in seeking treatment among malaria patients during the pre-certification phase in China Malaria J. (IF 3.0) Pub Date : 2024-03-11 Lianyu Jia, Xiaoyu Chen, Zhanchun Feng, Shangfeng Tang, Da Feng
Delays in malaria treatment can not only lead to severe and even life-threatening complications, but also foster transmission, putting more people at risk of infection. This study aimed to investigate the factors influencing treatment delays among malaria patients and their health-seeking behaviour. The medical records of 494 patients diagnosed with malaria from 6 different malaria-endemic provinces
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First report of natural infection of Anopheles gambiae s.s. and Anopheles coluzzii by Wolbachia and Microsporidia in Benin: a cross-sectional study Malaria J. (IF 3.0) Pub Date : 2024-03-11 Minassou Juvénal Ahouandjinou, Arthur Sovi, Aboubakar Sidick, Wilfried Sewadé, Come Zinsou Koukpo, Saïd Chitou, Linda Towakinou, Bruno Adjottin, Steve Hougbe, Filémon Tokponnon, Germain Gil Padonou, Martin Akogbéto, Louisa A. Messenger, Razaki A. Ossè
Recently, bacterial endosymbiont, including Wolbachia and Microsporidia were found to limit the infection of Anopheles mosquitoes with Plasmodium falciparum. This study aimed to investigate the natural presence of key transmission-blocking endosymbionts in Anopheles gambiae and Anopheles coluzzii in Southern Benin. The present study was conducted in seven communes (Cotonou, Porto-Novo, Aguégués, Ifangni
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Trends of Plasmodium falciparum molecular markers associated with resistance to artemisinins and reduced susceptibility to lumefantrine in Mainland Tanzania from 2016 to 2021 Malaria J. (IF 3.0) Pub Date : 2024-03-09 Catherine Bakari, Celine I. Mandara, Rashid A. Madebe, Misago D. Seth, Billy Ngasala, Erasmus Kamugisha, Maimuna Ahmed, Filbert Francis, Samwel Bushukatale, Mercy Chiduo, Twilumba Makene, Abdunoor M. Kabanywanyi, Muhidin K. Mahende, Reginald A. Kavishe, Florida Muro, Sigsbert Mkude, Renata Mandike, Fabrizio Molteni, Frank Chacky, Dunstan R. Bishanga, Ritha J. A. Njau, Marian Warsame, Bilali Kabula
Therapeutic efficacy studies (TESs) and detection of molecular markers of drug resistance are recommended by the World Health Organization (WHO) to monitor the efficacy of artemisinin-based combination therapy (ACT). This study assessed the trends of molecular markers of artemisinin resistance and/or reduced susceptibility to lumefantrine using samples collected in TES conducted in Mainland Tanzania
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RNAscope in situ hybridization reveals microvascular sequestration of Plasmodium relictum pSGS1 blood stages but absence of exo-erythrocytic dormant stages during latent infection of Serinus canaria Malaria J. (IF 3.0) Pub Date : 2024-03-08 Tanja Himmel, Josef Harl, Julia Matt, Nora Nedorost, Tatjana Iezhova, Mikas Ilgūnas, Gediminas Valkiūnas, Herbert Weissenböck
Birds chronically infected with avian malaria parasites often show relapses of parasitaemia after latent stages marked by absence of parasites in the peripheral circulation. These relapses are assumed to result from the activation of dormant exo-erythrocytic stages produced during secondary (post-erythrocytic) merogony of avian Plasmodium spp. Yet, there is no morphological proof of persistent or dormant
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The impact of agrochemical pollutant mixtures on the selection of insecticide resistance in the malaria vector Anopheles gambiae: insights from experimental evolution and transcriptomics Malaria J. (IF 3.0) Pub Date : 2024-03-05 Christabelle G. Sadia, Jean-Marc Bonneville, Marius G. Zoh, Behi K. Fodjo, France-Paraudie A. Kouadio, Sebastien K. Oyou, Benjamin G. Koudou, Beatrice A. Adepo-Gourene, Stephane Reynaud, Jean-Philippe David, Chouaibou S. Mouahamadou
There are several indications that pesticides used in agriculture contribute to the emergence and spread of resistance of mosquitoes to vector control insecticides. However, the impact of such an indirect selection pressure has rarely been quantified and the molecular mechanisms involved are still poorly characterized. In this context, experimental selection with different agrochemical mixtures was
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Evaluating the performance of Plasmodium falciparum genetic metrics for inferring National Malaria Control Programme reported incidence in Senegal Malaria J. (IF 3.0) Pub Date : 2024-03-05 Wesley Wong, Stephen F. Schaffner, Julie Thwing, Mame Cheikh Seck, Jules Gomis, Younouss Diedhiou, Ngayo Sy, Medoune Ndiop, Fatou Ba, Ibrahima Diallo, Doudou Sene, Mamadou Alpha Diallo, Yaye Die Ndiaye, Mouhamad Sy, Aita Sene, Djiby Sow, Baba Dieye, Abdoulaye Tine, Jessica Ribado, Joshua Suresh, Albert Lee, Katherine E. Battle, Joshua L. Proctor, Caitlin A. Bever, Bronwyn MacInnis, Daouda Ndiaye, Daniel
Genetic surveillance of the Plasmodium falciparum parasite shows great promise for helping National Malaria Control Programmes (NMCPs) assess parasite transmission. Genetic metrics such as the frequency of polygenomic (multiple strain) infections, genetic clones, and the complexity of infection (COI, number of strains per infection) are correlated with transmission intensity. However, despite these
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Insecticide-treated bed nets and residual indoor spraying reduce malaria in areas with low transmission: a reanalysis of the Maltrials study Malaria J. (IF 3.0) Pub Date : 2024-03-04 Taye Gari, Bernt Lindtjørn
The malaria incidence data from a malaria prevention study from the Rift Valley, Central Ethiopia, were reanalysed. The objective was to investigate whether including an administrative structure within the society, which may have required consideration in the protocol or previous analysis, would provide divergent outcomes on the effect measures of the interventions. A cluster-randomized controlled
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Early morning anopheline mosquito biting, a potential driver of malaria transmission in Busia County, western Kenya Malaria J. (IF 3.0) Pub Date : 2024-03-04 Julius I. Odero, Bernard Abong’o, Vincent Moshi, Sheila Ekodir, Steven A. Harvey, Eric Ochomo, John E. Gimnig, Nicole L. Achee, John P. Grieco, Prisca A. Oria, April Monroe
Insecticide-treated nets (ITNs) contributed significantly to the decline in malaria since 2000. Their protective efficacy depends not only on access, use, and net integrity, but also location of people within the home environment and mosquito biting profiles. Anopheline mosquito biting and human location data were integrated to identify potential gaps in protection and better understand malaria transmission
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Adult mosquitoes of the sibling species Anopheles gambiae and Anopheles coluzzii exhibit contrasting patterns of susceptibility to four neonicotinoid insecticides along an urban-to-rural gradient in Yaoundé, Cameroon Malaria J. (IF 3.0) Pub Date : 2024-03-02 Fred A. Ashu, Caroline Fouet, Marilene M. Ambadiang, Véronique Penlap-Beng, Colince Kamdem
Neonicotinoids are potential alternatives for controlling pyrethroid-resistant mosquitoes, but their efficacy against malaria vector populations of sub-Saharan Africa has yet to be investigated. The aim of the present study was to test the efficacy of four neonicotinoids against adult populations of the sibling species Anopheles gambiae and Anopheles coluzzii sampled along an urban-to-rural gradient
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Progress towards malaria elimination in the Greater Mekong Subregion: perspectives from the World Health Organization Malaria J. (IF 3.0) Pub Date : 2024-03-01 Giulia Manzoni, Rady Try, Jean Olivier Guintran, Céline Christiansen-Jucht, Elodie Jacoby, Siv Sovannaroth, Zaixing Zhang, Vilasack Banouvong, Matthew Scott Shortus, Rita Reyburn, Chitsavang Chanthavisouk, Nay Yi Yi Linn, Badri Thapa, San Kyawt Khine, Prayuth Sudathip, Deyer Gopinath, Nguyen Quang Thieu, Mya Sapal Ngon, Dai Tran Cong, Liu Hui, James Kelley, Neena Nee Kesar Valecha, Maria Dorina Bustos
Malaria remains a global health challenge, disproportionately affecting vulnerable communities. Despite substantial progress, the emergence of anti-malarial drug resistance poses a constant threat. The Greater Mekong Subregion (GMS), which includes Cambodia, China’s Yunnan province, Lao People's Democratic Republic, Myanmar, Thailand, and Viet Nam has been the epicentre for the emergence of resistance
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Correction: Testing and treatment for malaria elimination: a systematic review Malaria J. (IF 3.0) Pub Date : 2024-03-01 Gretchen Newby, Chris Cotter, Michelle E. Roh, Kelly Harvard, Adam Bennett, Jimee Hwang, Nakul Chitnis, Sydney Fine, Gillian Stresman, Ingrid Chen, Roly Gosling, Michelle S. Hsiang
Correction: Malaria Journal (2023) 22:254 https://doi.org/10.1186/s12936-023-04670-8 Following publication of the original article [1], the authors flagged two sets of errors (one in the Results and the other in Table 2) and made one clarification (in the caption of Figure 4): The first error arose because they updated Fig. 3 prior to submission but neglected to update the accompanying text; the second
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Malaria elimination and the need for intensive inter-country cooperation. a critical evaluation of regional technical co-operation in Southern Africa Malaria J. (IF 3.0) Pub Date : 2024-02-28 Chadwick H. Sikaala, Bongani Dlamini, Alphart Lungu, Phelele Fakudze, Mukosha Chisenga, Chishala Lukwesa Siame, Nyasha Mwendera, Dumisani Shaba, John M. Chimumbwa, Immo Kleinschmidt
Malaria elimination requires closely co-ordinated action between neighbouring countries. In Southern Africa several countries have reduced malaria to low levels, but the goal of elimination has eluded them thus far. The Southern Africa Development Community (SADC) Malaria Elimination Eight (E8) initiative was established in 2009 between Angola, Botswana, Eswatini, Mozambique, Namibia, South Africa
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Safety and efficacy of pyronaridine–artesunate paediatric granules in the treatment of uncomplicated malaria in children: insights from randomized clinical trials and a real-world study Malaria J. (IF 3.0) Pub Date : 2024-02-28 Michael Ramharter, Abdoulaye A. Djimde, Isabelle Borghini-Fuhrer, Robert Miller, Jangsik Shin, Adam Aspinall, Naomi Richardson, Martina Wibberg, Lawrence Fleckenstein, Sarah Arbe-Barnes, Stephan Duparc
Children are particularly at risk of malaria. This analysis consolidates the clinical data for pyronaridine–artesunate (PA) paediatric granules in children from three randomized clinical trials and a real-world study (CANTAM). An integrated safety analysis of individual patient data from three randomized clinical trials included patients with microscopically-confirmed Plasmodium falciparum, body weight ≥ 5 kg
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Sibling species of the major malaria vector Anopheles gambiae display divergent preferences for aquatic breeding sites in southern Nigeria Malaria J. (IF 3.0) Pub Date : 2024-02-27 Faith I. Ebhodaghe, Irma Sanchez-Vargas, Clement Isaac, Brian D. Foy, Elizabeth Hemming-Schroeder
When integrated with insecticide-treated bed nets, larval control of Anopheles mosquitoes could fast-track reductions in the incidence of human malaria. However, larval control interventions may deliver suboptimal outcomes where the preferred breeding places of mosquito vectors are not well known. This study investigated the breeding habitat choices of Anopheles mosquitoes in southern Nigeria. The objective
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How using light touch immersion research revealed important insights into the lack of progress in malaria elimination in Eastern Indonesia Malaria J. (IF 3.0) Pub Date : 2024-02-27 Dee Jupp, Sherria Ayuandini, Frisca Tobing, Denny Halim, Enny Kenangalem, Maria E. Sumiwi, Hellen D. Prameswari, Minerva Theodora, Hermawan Susanto, Riskha T. P. Dewi, Dedy Supriyanto, Bayu Kurnia, Mrunal Shetye, Ermi Ndoen, Yuka Onishi
By 2022, the Government of Indonesia had successfully eliminated malaria in 389 out of 514 districts but continues to face a challenge in Eastern Indonesia where 95% of the total 2021 malaria cases were reported from Papua, West Papua and Nusa Tenggara Timur provinces. There is an increased recognition that malaria elimination will require a better understanding of the human behavioural factors hindering
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Competency of malaria laboratory diagnosis at national and provincial levels at the beginning of malaria post-elimination phase, China Malaria J. (IF 3.0) Pub Date : 2024-02-26 He Yan, Mei Li, Zhi-gui Xia, Jian-hai Yin
Qualified malaria diagnosis competency has contributed to the great achievement of malaria elimination in China. After eliminating malaria, it is still critical to the prevention of re-establishment of malaria transmission in China. This study was aimed to assess the malaria detection competency at national and provincial levels in China at the beginning of malaria post-elimination phase. In the present
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Bayesian spatio-temporal analysis of malaria prevalence in children between 2 and 10 years of age in Gabon Malaria J. (IF 3.0) Pub Date : 2024-02-23 Fabrice Mougeni, Bertrand Lell, Ngianga-Bakwin Kandala, Tobias Chirwa
Gabon still bears significant malaria burden despite numerous efforts. To reduce this burden, policy-makers need strategies to design effective interventions. Besides, malaria distribution is well known to be related to the meteorological conditions. In Gabon, there is limited knowledge of the spatio-temporal effect or the environmental factors on this distribution. This study aimed to investigate
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Radical cure for Plasmodium vivax malaria after G6PD qualitative testing in four provinces in Cambodia, results from Phase I implementation Malaria J. (IF 3.0) Pub Date : 2024-02-23 Dysoley Lek, Yu-Cheng Tsai, Jillian Hirano, Siv Sovannaroth, Voeurng Bunreth, Prak Vonn, Or Vannthen, Tol Bunkea, Top Samphornarann, Nguon Sokomar, Mak Sarath, Soy Ty Kheang, Evelyn Wong, Michelle K. Burbach, Jayme Hughes, Huy Rekol
Cambodia aims to eliminate all forms of malaria by 2025. In 2020, 90% of all malaria cases were Plasmodium vivax. Thus, preventing P. vivax and relapse malaria is a top priority for elimination. 14-day primaquine, a World Health Organization-recommended radical cure treatment regimen, specifically targets dormant hypnozoites in the liver to prevent relapse. Cambodia introduced P. vivax radical cure
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Genetic differentiation of Plasmodium vivax duffy binding protein in Ethiopia and comparison with other geographical isolates Malaria J. (IF 3.0) Pub Date : 2024-02-23 Abnet Abebe, Cheikh Cambel Dieng, Sisay Dugassa, Deriba Abera, Tassew T. Shenkutie, Ashenafi Assefa, Didier Menard, Eugenia Lo, Lemu Golassa
Plasmodium vivax Duffy binding protein (PvDBP) is a merozoite surface protein located in the micronemes of P. vivax. The invasion of human reticulocytes by P. vivax merozoites depends on the parasite DBP binding domain engaging Duffy Antigen Receptor for Chemokine (DARC) on these red blood cells (RBCs). PvDBPII shows high genetic diversity which is a major challenge to its use in the development of
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Risk factors for non-participation in ivermectin and dihydroartemisinin-piperaquine mass drug administration for malaria control in the MASSIV trial Malaria J. (IF 3.0) Pub Date : 2024-02-22 Christian Kositz, Hristina Vasileva, Nuredin Mohammed, Jane Achan, Edgard Diniba Dabira, Umberto D’Alessandro, John Bradley, Michael Marks
Mass Drug Administration (MDA) has become a mainstay for the control of several diseases over the last two decades. Successful implementation of MDA programmes requires community participation and can be threatened by systematic non-participation. Such concerns are particularly pertinent for MDA programmes against malaria, as they require multi-day treatment over several consecutive months. Factors
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Correlative light-electron microscopy methods to characterize the ultrastructural features of the replicative and dormant liver stages of Plasmodium parasites Malaria J. (IF 3.0) Pub Date : 2024-02-21 Gabriel Mitchell, Laura Torres, Matthew E. Fishbaugher, Melanie Lam, Vorada Chuenchob, Reena Zalpuri, Shreya Ramasubban, Caitlin N. Baxter, Erika L. Flannery, Anke Harupa, Sebastian A. Mikolajczak, Danielle M. Jorgens
The infection of the liver by Plasmodium parasites is an obligatory step leading to malaria disease. Following hepatocyte invasion, parasites differentiate into replicative liver stage schizonts and, in the case of Plasmodium species causing relapsing malaria, into hypnozoites that can lie dormant for extended periods of time before activating. The liver stages of Plasmodium remain elusive because
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Trend analysis of malaria surveillance data in West Wallaga, West Oromia, Ethiopia: a framework for planning and elimination Malaria J. (IF 3.0) Pub Date : 2024-02-21 Sahilu Tesfaye, Aman Yesuf
Although Ethiopia has made a remarkable progress towards malaria prevention and control, malaria remains one of the most devastating parasitic diseases affecting humans. However, the distribution and transmission of malaria varies across the country. The study aimed to describe 5 years of malaria distribution and magnitude within the West Wallaga Zone and its respective woredas. A retrospective cross-sectional
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Making the most of malaria chemoprevention Malaria J. (IF 3.0) Pub Date : 2024-02-19 Jasper Littmann, Dorothy Achu, Miriam K. Laufer, Corine Karema, David Schellenberg
Against a backdrop of stalled progress in malaria control, it is surprising that the various forms of malaria chemoprevention are not more widely used. The World Health Organization (WHO) has recommended several malaria chemoprevention strategies, some of them for over a decade, and each with documented efficacy and cost effectiveness. In 2022, the WHO updated and augmented its malaria chemoprevention
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Time series analysis of malaria cases to assess the impact of various interventions over the last three decades and forecasting malaria in India towards the 2030 elimination goals Malaria J. (IF 3.0) Pub Date : 2024-02-15 Mrigendra P. Singh, Harsh Rajvanshi, Praveen K. Bharti, Anup R. Anvikar, Altaf A. Lal
Despite the progress made in this decade towards malaria elimination, it remains a significant public health concern in India and many other countries in South Asia and Asia Pacific region. Understanding the historical trends of malaria incidence in relation to various commodity and policy interventions and identifying the factors associated with its occurrence can inform future intervention strategies
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Using serological diagnostics to characterize remaining high-incidence pockets of malaria in forest-fringe Cambodia Malaria J. (IF 3.0) Pub Date : 2024-02-15 Mathilde Grimée, Costanza Tacoli, Mirco Sandfort, Thomas Obadia, Aimee R. Taylor, Amélie Vantaux, Leanne J. Robinson, Dysoley Lek, Rhea J. Longley, Ivo Mueller, Jean Popovici, Michael T. White, Benoît Witkowski
Over the last decades, the number of malaria cases has drastically reduced in Cambodia. As the overall prevalence of malaria in Cambodia declines, residual malaria transmission becomes increasingly fragmented over smaller remote regions. The aim of this study was to get an insight into the burden and epidemiological parameters of Plasmodium infections on the forest-fringe of Cambodia. 950 participants
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Classification and clinical significance of immunogenic cell death-related genes in Plasmodium falciparum infection determined by integrated bioinformatics analysis and machine learning Malaria J. (IF 3.0) Pub Date : 2024-02-15 Yan-hui Zhang, Li-hua Xie, Jian Li, Yan-wei Qi, Jia-jian Shi
Immunogenic cell death (ICD) is a type of regulated cell death that plays a crucial role in activating the immune system in response to various stressors, including cancer cells and pathogens. However, the involvement of ICD in the human immune response against malaria remains to be defined. In this study, data from Plasmodium falciparum infection cohorts, derived from cross-sectional studies, were
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Evaluation of the malaria case surveillance system in KwaZulu-Natal Province, South Africa, 2022: a focus on DHIS2 Malaria J. (IF 3.0) Pub Date : 2024-02-14 Maxwell Mabona, Thembekile Zwane, Jaishree Raman, Lazarus Kuonza, Babongile Mhlongo, Poncho Phafane
South Africa set a target to eliminate malaria by 2023, with KwaZulu-Natal (KZN) Province the malaria-endemic province closest to achieving this goal. Objective two of the National Malaria Elimination Strategic Plan (NMESP) focused on strengthening surveillance systems to support the country’s elimination efforts. Regular evaluations of the malaria surveillance systems against the targets of the NMESP
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A machine learning approach for early identification of patients with severe imported malaria Malaria J. (IF 3.0) Pub Date : 2024-02-13 Alessandra D’Abramo, Francesco Rinaldi, Serena Vita, Riccardo Mazzieri, Angela Corpolongo, Claudia Palazzolo, Tommaso Ascoli Bartoli, Francesca Faraglia, Maria Letizia Giancola, Enrico Girardi, Emanuele Nicastri
The aim of this study is to design ad hoc malaria learning (ML) approaches to predict clinical outcome in all patients with imported malaria and, therefore, to identify the best clinical setting. This is a single-centre cross-sectional study, patients with confirmed malaria, consecutively hospitalized to the Lazzaro Spallanzani National Institute for Infectious Diseases, Rome, Italy from January 2007
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Two promising candidates for paratransgenesis, Elizabethkingia and Asaia, increase in both sexes of Anopheles gambiae mosquitoes after feeding Malaria J. (IF 3.0) Pub Date : 2024-02-12 Richardson K. Egyirifa, Jewelna Akorli
The male mosquito microbiome may be important for identifying ideal candidates for disease control. Among other criteria, mosquito-associated symbionts that have high localization in both male and female mosquitoes and are transmissible through both vertical and sexual routes are desirable. However, mosquito microbiome studies have mainly been female-focused. In this study, the microbiota of male and
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Epigenetic regulation as a therapeutic target in the malaria parasite Plasmodium falciparum Malaria J. (IF 3.0) Pub Date : 2024-02-12 Thibaud Reyser, Lucie Paloque, Jean-Michel Augereau, Luisa Di Stefano, Françoise Benoit-Vical
Over the past thirty years, epigenetic regulation of gene expression has gained increasing interest as it was shown to be implicated in illnesses ranging from cancers to parasitic diseases. In the malaria parasite, epigenetics was shown to be involved in several key steps of the complex life cycle of Plasmodium, among which asexual development and sexual commitment, but also in major biological processes
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Evaluation of the malaria elimination programme in Muara Enim Regency: a qualitative study from Indonesia Malaria J. (IF 3.0) Pub Date : 2024-02-12 Hamzah Hasyim, Heni Marini, Misnaniarti Misnaniarti, Rostika Flora, Iche Andriyani Liberty, Ahmed Elagali, Hartoni Hartoni, Fadhilah Eka Maharani
Malaria remains an enduring public health concern in Indonesia, exacerbated by its equatorial climate that fosters the proliferation of Anopheles mosquitoes. This study seeks to assess the performance of the malaria elimination programme comprehensively. Between May and August 2022, a qualitative study was conducted in Muara Enim Regency, South Sumatra Province, involving 22 healthcare professionals
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Artificial nighttime lighting impacts Plasmodium falciparum mature stage V gametocytes infectivity in Anopheles stephensi Malaria J. (IF 3.0) Pub Date : 2024-02-08 Jose Luis Llergo, Helena Garuti, Celia Lopez, Julia Sanchez, David Calvo
Malaria is one of the most important vector-borne diseases of humans with an estimated 241 million cases worldwide in 2020. As an urban and periurban mosquito species, Anopheles stephensi is exposed to artificial human stimuli like light that can alter many aspects of mosquito behaviour, physiology and metabolism. Therefore, fluctuations in the light environment may influence the host, parasite and/or
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Assessing availability, prices, and market share of quality-assured malaria ACT and RDT in the private retail sector in Nigeria and Uganda Malaria J. (IF 3.0) Pub Date : 2024-02-06 Meley Woldeghebriel, Ezinne Aso, Erica Berlin, Chizoba Fashanu, Sylvia N. Kirumira, Felix Lam, Robert Mugerwa, Juliet Nakiganda, Tayo Olaleye, Jimmy Opigo, Funlola Osinupebi, Natalie Priestley, Rodger Stringham, Perpetua Uhomoibhi, Theodoor Visser, Abigail Ward, Owens Wiwa, Aaron Woolsey
An estimated 50% of suspected malaria cases in sub-Saharan Africa first seek care in the private sector, especially in private medicine retail outlets. Quality of care in these outlets is generally unknown but considered poor with many patients not receiving a confirmatory diagnosis or the recommended first-line artemisinin-based combination therapy (ACT). In 2010, a subsidy pilot scheme, the Affordable
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Effectiveness of artemether–lumefantrine for treating uncomplicated malaria in low- and high-transmission areas of Ghana Malaria J. (IF 3.0) Pub Date : 2024-02-05 Mawusi Adepa Mawuli, Linda Eva Amoah, Liwang Cui, Neils Ben Quashie, Yaw Asare Afrane
Artemisinin-based combination therapy (ACT) has been effective in the supervised treatment of uncomplicated malaria in Ghana. Since ACT usage is primarily unsupervised, this study aimed to determine the effectiveness of artemether–lumefantrine (AL) for treating malaria patients in two transmission settings in Ghana. Eighty-four individuals with uncomplicated Plasmodium falciparum malaria were recruited
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From efficacy to effectiveness: a comprehensive framework for monitoring, evaluating and optimizing seasonal malaria chemoprevention programmes Malaria J. (IF 3.0) Pub Date : 2024-02-02 Monica Anna de Cola, Elisabeth G. Chestnutt, Sol Richardson, Matthieu Baudry, Chuks Nnaji, Taiwo Ibinaiye, Azoukalné Moukénet, Kunle Rotimi, Benoît Sawadogo, Joshua Okafor, Cheick Saïd Compaoré, Chibuzo Oguoma, Christian Rassi, Arantxa Roca-Feltrer
Seasonal Malaria Chemoprevention (SMC) is a highly effective intervention for preventing malaria, particularly in areas with highly seasonal transmission. Monitoring and evaluating (M&E) SMC programmes are complex due to the scale, time-sensitive delivery of the programme, and influence of external factors. This paper describes the process followed to develop a comprehensive M&E framework tailored
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Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines Malaria J. (IF 3.0) Pub Date : 2024-02-02 Usa Boonyuen, Beatriz Aira C. Jacob, Jutamas Wongwigkan, Kamonwan Chamchoy, Natsamon Singha-art, Natnicha Pengsuk, Duantida Songdej, Emily R. Adams, Thomas Edwards, Supat Chamnanchanunt, Syazwani Itri Amran, Nurriza Ab Latif, Naveen Eugene Louis, Shamini Chandran
It was hypothesized that glucose-6-phosphate dehydrogenase (G6PD) deficiency confers a protective effect against malaria infection, however, safety concerns have been raised regarding haemolytic toxicity caused by radical cure with 8-aminoquinolines in G6PD-deficient individuals. Malaria elimination and control are also complicated by the high prevalence of G6PD deficiency in malaria-endemic areas
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Forest-goers as a heterogeneous population at high-risk for malaria: a case–control study in Aceh Province, Indonesia Malaria J. (IF 3.0) Pub Date : 2024-01-30 Sarah Gallalee, Iska Zarlinda, Martha G. Silaen, Chris Cotter, Carmen Cueto, Iqbal R. F. Elyazar, Jerry O. Jacobson, Roly Gosling, Michelle S. Hsiang, Adam Bennett, Farah N. Coutrier, Jennifer L. Smith
A major challenge to malaria elimination is identifying and targeting populations that are harbouring residual infections and contributing to persistent transmission. In many near-elimination settings in Southeast Asia, it is known that forest-goers are at higher risk for malaria infection, but detailed information on their behaviours and exposures is not available. In Aceh Province, Indonesia, a near-elimination
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Molecular surveillance of Kelch 13 polymorphisms in Plasmodium falciparum isolates from Kenya and Ethiopia Malaria J. (IF 3.0) Pub Date : 2024-01-29 Brook Jeang, Daibin Zhong, Ming-Chieh Lee, Harrysone Atieli, Delenasaw Yewhalaw, Guiyun Yan
Timely molecular surveillance of Plasmodium falciparum kelch 13 (k13) gene mutations is essential for monitoring the emergence and stemming the spread of artemisinin resistance. Widespread artemisinin resistance, as observed in Southeast Asia, would reverse significant gains that have been made against the malaria burden in Africa. The purpose of this study was to assess the prevalence of k13 polymorphisms
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msp1, msp2, and glurp genotyping to differentiate Plasmodium falciparum recrudescence from reinfections during prevention of reestablishment phase, Sri Lanka, 2014–2019 Malaria J. (IF 3.0) Pub Date : 2024-01-27 Kumudunayana T. Gunasekera, Risintha G. Premaratne, Shiroma M. Handunnetti, Jagathpriya Weerasena, Sunil Premawansa, Deepika S. Fernando
Sri Lanka after eliminating malaria in 2012, is in the prevention of re-establishment (POR) phase. Being a tropical country with high malariogenic potential, maintaining vigilance is important. All malaria cases are investigated epidemiologically and followed up by integrated drug efficacy surveillance (iDES). Occasionally, that alone is not adequate to differentiate Plasmodium falciparum reinfections
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Emergence of Plasmodium falciparum strains with artemisinin partial resistance in East Africa and the Horn of Africa: is there a need to panic? Malaria J. (IF 3.0) Pub Date : 2024-01-25 Ashenafi Assefa, Abebe A. Fola, Geremew Tasew
The emergence and spread of artemisinin partial resistance in East and Horn of Africa is alarming. However, artemisinin-based combination therapy (ACT) generally remains efficacious for the treatment of falciparum malaria. The emergence of partial artemisinin resistance does not currently meet the criteria to initiate change on treatment guidelines nor affect ACT routine procurement and distribution
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A quasi-experimental study to estimate effectiveness of seasonal malaria chemoprevention in Aweil South County in Northern Bahr El Ghazal, South Sudan Malaria J. (IF 3.0) Pub Date : 2024-01-24 Jamshed Khan, Maria Suau Sans, Francis Okot, Abubaker Rom Ayuiel, Jonathan Magoola, Christian Rassi, Sikai Huang, Denis Mubiru, Craig Bonnington, Kevin Baker, Julla Ahmed, Chuks Nnaji, Sol Richardson
Seasonal malaria chemoprevention (SMC) is an effective intervention to prevent malaria in children in locations where the burden of malaria is high and transmission is seasonal. There is growing evidence suggesting that SMC with sulfadoxine–pyrimethamine and amodiaquine can retain its high level of effectiveness in East and Southern Africa despite resistance concerns. This study aims to generate evidence
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Analysing the six-year malaria trends at Metehara Health Centre in Central Ethiopia: the impact of resurgence on the 2030 elimination goals Malaria J. (IF 3.0) Pub Date : 2024-01-23 Aynalem Mandefro, Geletta Tadele, Bacha Mekonen, Lemu Golassa
Despite Ethiopia’s concerted efforts to eliminate malaria by 2030, the disease continues to pose a significant public health and socioeconomic challenge in the country. The year 2021 witnessed 2.78 million malaria cases and 8041 associated deaths, emphasizing the persistent threat. Monitoring the prevalence trend of malaria is crucial for devising effective control and elimination strategies. This
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Impact of a spatial repellent intervention on Anopheles kdr insecticide resistance allele in Sumba, Indonesia Malaria J. (IF 3.0) Pub Date : 2024-01-22 Lepa Syahrani, Puji B. S. Asih, Anom Bowolaksono, Astari Dwiranti, Siti Zubaidah, Ismail E. Rozi, Dendi H. Permana, Claus Bøgh, Michael J. Bangs, John P. Grieco, Nicole L. Achee, Neil F. Lobo, Din Syafruddin
The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this residual transmission. With limited options for effective insecticides, regular resistance monitoring is warranted for selecting and using appropriate tools. This study evaluates the pyrethroid knockdown
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Epidemiological behaviour and interventions of malaria in Niger, 2010–2019: a time-series analysis of national surveillance data Malaria J. (IF 3.0) Pub Date : 2024-01-19 Ali Issakou Malam Tchole, Run-Ze Ye, Qing Xu, Zhen-Wei Li, Jin-Yue Liu, Shan-Shan Wang, Jing Liu, Xiao-Yang Wang, Alassan Maman Bachir, Lin Zhao, Wu-Chun Cao
Malaria remains a significant public health concern in Niger, with the number of cases increasing from 592,334 in 2000 to 3,138,696 in 2010. In response, a concerted campaign against the disease has been initiated. However, the implementation of these malaria interventions and their association with epidemiological behaviour remains unclear. A time-series study was conducted in Niger from 2010 to 2019
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Dynamics of malaria vector composition and Plasmodium falciparum infection in mainland Tanzania: 2017–2021 data from the national malaria vector entomological surveillance Malaria J. (IF 3.0) Pub Date : 2024-01-19 Charles D. Mwalimu, Samson Kiware, Rosemary Nshama, Yahya Derua, Pendael Machafuko, Peter Gitanya, Winfred Mwafongo, Jubilate Bernard, Basiliana Emidi, Victor Mwingira, Robert Malima, Victoria Githu, Brian Masanja, Yeromin Mlacha, Patrick Tungu, Bilali Kabula, Edward Sambu, Bernard Batengana, Johnson Matowo, Nicodem Govella, Prosper Chaki, Samwel Lazaro, Naomi Serbantez, Jovin Kitau, Stephen M. Magesa
In 2015, Tanzania National Malaria Control Programme (NMCP) established a longitudinal malaria vector entomological surveillance (MVES). The MVES is aimed at a periodical assessment of malaria vector composition and abundance, feeding and resting behaviours, and Plasmodium falciparum infection in different malaria epidemiological strata to guide the NMCP on the deployment of appropriate malaria vector
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Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria Malaria J. (IF 3.0) Pub Date : 2024-01-19 Ronke Olowojesiku, Meredith G. Sherman, Amina M. Mukadam, Rami Imam, Kennedy M. Chastang, Karl B. Seydel, Alice M. Liomba, John R. Barber, Nicole F. O’Brien, Douglas G. Postels
In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker associated with death. The usefulness of post-admission measurements of blood lactate in children with CM is less clear. The strength of association between blood lactate and neurological sequelae in CM survivors, as well as the optimal duration
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Genomic insights into Plasmodium vivax population structure and diversity in central Africa Malaria J. (IF 3.0) Pub Date : 2024-01-18 Valerie Gartner, Benjamin D. Redelings, Claudia Gaither, Jonathan B. Parr, Albert Kalonji, Fernandine Phanzu, Nicholas F. Brazeau, Jonathan J. Juliano, Gregory A. Wray
Though Plasmodium vivax is the second most common malaria species to infect humans, it has not traditionally been considered a major human health concern in central Africa given the high prevalence of the human Duffy-negative phenotype that is believed to prevent infection. Increasing reports of asymptomatic and symptomatic infections in Duffy-negative individuals throughout Africa raise the possibility
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In-vitro susceptibility and ex-vivo evaluation of macrocyclic lactone endectocides sub-lethal concentrations against Plasmodium vivax oocyst development in Anopheles arabiensis Malaria J. (IF 3.0) Pub Date : 2024-01-18 Gemechu Zeleke, Luc Duchateau, Delenasaw Yewhalaw, Sultan Suleman, Mathias Devreese
Asymptomatic malaria transmission has become a public health concern across malaria-endemic Africa including Ethiopia. Specifically, Plasmodium vivax is more efficient at transmitting earlier in the infection and at lower densities than Plasmodium falciparum. Consequently, a greater proportion of individuals infected with P. vivax can transmit without detectable gametocytaemia. Mass treatment of livestock
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Triple artemisinin-based combination therapy (TACT): advancing malaria control and eradication efforts Malaria J. (IF 3.0) Pub Date : 2024-01-18 Emmanuel Kokori, Gbolahan Olatunji, Adeola Akinboade, Aminat Akinoso, Emmanuel Egbunu, Sikiru Ademola Aremu, Chuka Emmanuel Okafor, Olamide Oluwole, Nicholas Aderinto
This paper examines the far-reaching implications of Triple Artemisinin-Based Combination Therapy (TACT) in the global battle against malaria. Artemisinin-Based Combination Therapy (ACT) is recognized for its cost-effectiveness, lower likelihood of adverse events, and widespread acceptance by patients and healthcare providers. However, TACT introduces novel dimensions to the fight against malaria that
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Presence and abundance of malaria vector species in Miami-Dade County, Florida Malaria J. (IF 3.0) Pub Date : 2024-01-18 André B. B. Wilke, Chalmers Vasquez, Johana Medina, Isik Unlu, John C. Beier, Marco Ajelli
Malaria outbreaks have sporadically occurred in the United States, with Anopheles quadrimaculatus serving as the primary vector in the eastern region. Anopheles crucians, while considered a competent vector, has not been directly implicated in human transmission. Considering the locally acquired Plasmodium vivax cases in Sarasota County, Florida (7 confirmed cases), Cameron County, Texas (one confirmed
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Multiple Anopheles species complicate downstream analysis and decision-making in a malaria pre-elimination area in southern Mozambique Malaria J. (IF 3.0) Pub Date : 2024-01-18 Mara Máquina, Mercy A. Opiyo, Nelson Cuamba, Dulcisária Marrenjo, Maria Rodrigues, Sarmento Armando, Sheila Nhate, Fabião Luis, Francisco Saúte, Baltazar Candrinho, Neil F. Lobo, Krijn P. Paaijmans
Different anopheline species (even within a species group/complex) can differ in their feeding and resting behaviours, which impact both malaria transmission patterns as well as the efficacy of vector control interventions. While morphological identification of sampled specimens is an important first step towards understanding species diversity and abundance, misidentification can result in the implementation