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Simultaneous detection of breast cancer biomarkers circROBO1 and BRCA1 based on a CRISPR-Cas13a/Cas12a system Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-08 Chengchen Tan, Guoyang Xie, Song Wu, Cailu Song, Jinhui Zhang, Xinyao Yi, Jianxiu Wang, Hailin Tang
Breast cancer is reported to be one of the most lethal cancers in women, and its multi-target detection can help improve the accuracy of diagnosis. In this work, a cluster regularly interspaced short palindromic repeats (CRISPR)-Cas13a/Cas12a-based system was established for the simultaneous fluorescence detection of breast cancer biomarkers circROBO1 and BRCA1. CRISPR-Cas13a and CRISPR-Cas12a were
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Laponite-activated AIE supramolecular assembly with modulating multicolor luminescence for logic digital encryption and perfluorinated pollutant detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-06 Wei-Lei Zhou, Yun-Ga Wu, Siwei Wang, Rong Zhang, Li-Hua Wang, Jinglin Liu, Xiufang Xu
Recently, the non-covalently activated supramolecular scaffold method has become a prominent research area in the field of intelligent materials. Here, the inorganic clay (LP) promoted the AIE properties of 4,4′,4″,4‴-(ethene-1,1,2,2-tetrayltetrakis(benzene-4,1-diyl))tetrakis(1-ethylpyridin-1-ium) (P-TPE), showing an astonishing 42-fold enhancement of the emission intensity of the yellow-green luminescence
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All-printed wearable biosensor based on MWCNT-iron oxide nanocomposite ink for physiological level detection of glucose in human sweat Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-04 Chandradas Shamili, Adarsh Sivan Pillai, Saisree S, Achu Chandran, Manoj Raama Varma, Surendran Kuzhichalil Peethambharan
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Rapid, on-site quantitative determination of mycotoxins in grains using a multiple time-resolved fluorescent microsphere immunochromatographic test strip Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-03 JunFa Liang, Xuewei Li, Bin Huang, Yupeng Pan, Zile Zhuang, Qiuxiong Ye, Cheng Peng, Huangyi Deng, Yunting Yi, Binbin Zhang, Peiyi Chen, Xuncai Chen
The label probe plays a crucial role in enhancing the sensitivity of lateral flow immunoassays. However, conventional fluorescent microspheres (FMs) have limitations due to their short fluorescence lifetime, susceptibility to background fluorescence interference, and inability to facilitate multi-component detection. In this study, carboxylate-modified Eu(III)-chelate-doped polystyrene nanobeads were
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Needle-in-needle electrochemical sensor for in-vivo monitoring of anticancer drug etoposide Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-03 Weilu Liu, Qiuyun Li, Qiushuo han
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Dual-ligand Eu-MOF/CuS@Au Heterostructure Array-based ECL Sensor for MiRNA-128 Detection in Glioblastoma Tissues Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-01 Wenyan Li, Zihui Liang, Peilin Wang, Zhenrun Li, Qiang Ma
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Synergistic enhancement of wearable biosensor through Pt single-atom catalyst for sweat analysis Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-01 Yong Zhang, Zhihao Yang, Cailin Qiao, Yiyi Liu, Cuncun Wang, Xin Zeng, Jingzhou Hou, Danqun Huo, Changjun Hou
Real-time monitoring of biological markers in sweat is a valuable tool for health assessment. In this study, we have developed an innovative wearable biosensor for precise analysis of glucose in sweat during physical activities. The sensor is based on a single-atom catalyst of platinum (Pt) uniformly dispersed on tricobalt tetroxide (CoO) nanorods and reduced graphene oxide (rGO), featuring a unique
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Deep learning-assisted monitoring of trastuzumab efficacy in HER2-Overexpressing breast cancer via SERS immunoassays of tumor-derived urinary exosomal biomarkers Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-01 Jinyoung Kim, Hye Young Son, Sojeong Lee, Hyun Wook Rho, Ryunhyung Kim, Hyein Jeong, Chaewon Park, Byeonggeol Mun, Yesol Moon, Eunji Jeong, Eun-Kyung Lim, Seungjoo Haam
Monitoring drug efficacy is significant in the current concept of companion diagnostics in metastatic breast cancer. Trastuzumab, a drug targeting human epidermal growth factor receptor 2 (HER2), is an effective treatment for metastatic breast cancer. However, some patients develop resistance to this therapy; therefore, monitoring its efficacy is essential. Here, we describe a deep learning-assisted
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Unraveling the structure-chirality sensing relationship between achiral anthracene-based tetracationic nanotubes and nucleosides in aqueous host-guest complexation Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-05-01 Ting Yang, Honghong Duan, Hao Nian, Pingxia Wang, Chaochao Yan, Fan Cao, Qingfang Li, Liping Cao
In biological systems, nucleosides play crucial roles in various physiological processes. In this study, we designed and synthesized four achiral anthracene-based tetracationic nanotubes (–) as artificial hosts and chiroptical sensors for nucleosides in aqueous media. Notably, different nanotubes exhibit varied chirality sensing on circular dichroism (CD)/circularly polarized luminescence (CPL) spectra
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A miniaturized wash-free microfluidic assay for electrical impedance-based assessment of red blood cell-mediated microvascular occlusion Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-30 Solomon Oshabaheebwa, Christopher A. Delianides, Akshay A. Patwardhan, Erica N. Evans, Zoe Sekyonda, Allison Bode, Faith M. Apio, Cissy K. Mutuluuza, Vivien A. Sheehan, Michael A. Suster, Umut A. Gurkan, Pedram Mohseni
The production of HbS — an abnormal hemoglobin (Hb) — in sickle cell disease (SCD) results in poorly deformable red blood cells (RBCs) that are prone to microcapillary occlusion, causing tissue ischemia and organ damage. Novel treatments, including gene therapy, may reduce SCD morbidity, but methods to functionally evaluate RBCs remain limited. Previously, we presented the microfluidic impedance red
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Fe-single-atom catalysts boosting electrochemiluminescence via bipolar electrode integrated with its peroxidase-like activity for bioanalysis Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-30 Xiaodong Chen, Huijuan Xv, Can Li, Linghui Kong, Chunxiang Li, Feng Li
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Development of a thermotaxis and rheotaxis microfluidic device for motile spermatozoa sorting Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-30 Teng-Kuan Huang, Chung-Hsien Huang, Pei-An Chen, Ching Hung Chen, Farn Lu, Wen-Ju Yang, Jack Yu Jen Huang, Bor-Ran Li
Male infertility is a pervasive global reproductive challenge, primarily attributed to a decline in semen quality. Addressing this concern, there has been a growing focus on spermatozoa sorting in assisted reproductive technology. This study introduces a groundbreaking development in the form of a thermotaxis and rheotaxis microfluidic (TRMC) device designed for efficient motile spermatozoa sorting
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Carbon nanotubes integrated photonic barcodes in Herringbone Microfluidics for Multiplex Biomarker Quantification Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-29 Xueqin Li, Rui Liu, Nan Zhang, Junqi Zhao, Yuanyang Zhou, Qing Zhou, Zhuxiao Gu, Dagan Zhang
Early monitoring of cardiovascular disease (CVD) is crucial for its treatment and prognosis. Hence, highly specific and sensitive detection method is urgently needed. In this study, we propose a novel herringbone microfluid chip with aptamer functionalized core-shell photonic crystal (PhC) barcode integration for high throughput multiplex CVD detection. Based on the PhC derived from co-assembled carboxylated
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Bilateral efforts to improve SERS detection efficiency of exosomes by Au/Na7PMo11O39 Combined with Phospholipid Epitope Imprinting Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-29 Qingnan Zhao, Xianhui Cheng, Saizhen Hu, Menghan Zhao, Junjie Chen, Ming Mu, Yumei Yang, Hao Liu, Lianghai Hu, Bing Zhao, Wei Song
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A “dual-key-and-lock” platform for distinguishing autophagy during neuroinflammation Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-27 Shuyang Zhai, Wei Hu, Zhihong Liu, Yingbin Liu
Autophagy is an essential degradative process that governs the renewal of organelle and maintains the homeostasis of cellular microenvironment. Its dysregulation has been demonstrated to be an indicator for neuroinflammation. To elucidate the interrelationship between neuroinflammation and autophagy, optical probes are ideal tools as they offer a number of advantages such as high spatiotemporal resolution
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Metal-organic polymer enables efficient organic photoelectrochemical transistor biosensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-27 Cheng Yuan, Qiqi Wu, Ke-Xin Xu, Xing-Shi Liu, Hao Lou, Yi-Tong Xu, Zheng Li, Yuanyuan Meng, Tan Li, Rui Ban, Guangxu Chen, Wei-Wei Zhao
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Integrated molybdenum single atom array sensors with multichannels for nitrite detection in foods Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-27 Mei Ding, Kangling Tian, Jingwen Wang, Yuhang Liu, Guangxuan Hu, Yan Zheng, Shaohui Lei, Jiayue Sun, Hong Bin Yang, Fang Xin Hu
Nitrite (NO) is present in a variety of foods, but the excessive intake of NO can indirectly lead to carcinogenic, teratogenic, mutagenicity and other risks to the human body. Therefore, the detection of NO is crucial for maintaining human health. In this study, an integrated array sensor for NO detection is developed based on molybdenum single atom material (IMS) using high-resolution electrohydrodynamic
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Enhanced CRISPR/Cas12a-based quantitative detection of nucleic acids using double emulsion droplets Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-26 Yang Zhang, Hangrui Liu, Yuta Nakagawa, Yuzuki Nagasaka, Tianben Ding, Shi-Yang Tang, Yaxiaer Yalikun, Keisuke Goda, Ming Li
Pairing droplet microfluidics and CRISPR/Cas12a techniques creates a powerful solution for the detection and quantification of nucleic acids at the single-molecule level, due to its specificity, sensitivity, and simplicity. However, traditional water-in-oil (W/O) single emulsion (SE) droplets often present stability issues, affecting the accuracy and reproducibility of assay results. As an alternative
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Low-cost inkjet-printed nanostructured biosensor based on CRISPR/Cas12a system for pathogen detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Angela Gilda Carota, Andrea Bonini, Massimo Urban, Noemi Poma, Federico Maria Vivaldi, Arianna Tavanti, Marianna Rossetti, Giulio Rosati, Arben Merkoçi, Fabio Di Francesco
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Detecting normal and cancer skin cells via glycosylation and adhesion signatures: A path to enhanced microfluidic phenotyping Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Renata Szydlak, Marcin Luty, Victorien E. Prot, Ingrid H. Øvreeide, Joanna Zemła, Bjørn T. Stokke, Małgorzata Lekka
Recruiting circulating cells based on interactions between surface receptors and corresponding ligands holds promise for capturing cells with specific adhesive properties. Our study investigates the adhesion of skin cells to specific lectins, particularly focusing on advancements in lectin-based biosensors with diagnostic potential. We explore whether we can successfully capture normal skin (melanocytes
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Aptamer-free upconversion nanoparticle/silk biosensor system for low-cost and highly sensitive detection of antibiotic residues Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Yajun Shuai, Na Li, Ying Zhang, Qing Bao, Tiancheng Wei, Tao Yang, Qichao Cheng, Wei Wang, Baolan Hu, Chuanbin Mao, Mingying Yang
The detection of antibiotics is crucial for safeguarding the environment, ensuring food safety, and promoting human health. However, developing a rapid, convenient, low-cost, and sensitive method for antibiotic detection presents significant challenges. Herein, an aptamer-free biosensor was successfully constructed using upconversion nanoparticles (UCNPs) coated with silk fibroin (SF), based on Förster
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Rapid prototyping and facile customization of conductive hydrogel bioelectronics based on all laser process Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Jin Kim, Daeyeon Won, Tae Hyun Kim, C-Yoon Kim, Seung Hwan Ko
Proper customization in size and shape is essential in implantable bioelectronics for stable bio-signal recording. Over the past decades, many researchers have heavily relied on conventional photolithography processes to fabricate implantable bioelectronics. Therefore, they could not avoid the critical limitation of high cost and complex processing steps to optimize bioelectronic devices for target
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Homochiral light-sensitive metal-organic framework photoelectrochemical gated transistor for enantioselective discrimination of monosaccharides Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Jian-Hong Zhu, Haiquan Wang, Junli Guo, Junjian Zhao, Zhida Gao, Yan-Yan Song, Chenxi Zhao
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Softening implantable bioelectronics: Material designs, applications, and future directions Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Subin Oh, Simok Lee, Sung Woo Kim, Choong Yeon Kim, Eun Young Jeong, Juhyun Lee, Do A Kwon, Jae-Woong Jeong
Implantable bioelectronics, integrated directly within the body, represent a potent biomedical solution for monitoring and treating a range of medical conditions, including chronic diseases, neural disorders, and cardiac conditions, through personalized medical interventions. Nevertheless, contemporary implantable bioelectronics rely heavily on rigid materials (e.g., inorganic materials and metals)
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OriPlex: Origami-enabled multiplexed detection of respiratory pathogens Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Andreu Vaquer, Cristina Adrover-Jaume, Antonio Clemente, Julia Viana, Rocío Rodríguez, Estrella Rojo-Molinero, Antonio Oliver, Roberto de la Rica
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Chip-based automated equipment for dual-mode point-of-care testing foodborne pathogens Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Binfeng Yin, Haoyu Zhu, Shiyu Zeng, A.S.M. Muhtasim Fuad Sohan, Xinhua Wan, Jun Liu, Pan Zhang, Xiaodong Lin
Foodborne pathogens have a substantial bearing on food safety and environmental health. The development of automated, portable and compact devices is essential for the on-site and rapid point-of-care testing (POCT) of bacteria. Here, this work developed a micro-automated microfluidic device for detecting bacteria, such as () O157:H7, using a seashell-like microfluidic chip (SMC) as an analysis and
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Magnetically modified bacteriophage-triggered ATP release activated EXPAR-CRISPR/Cas14a system for visual detection of Burkholderia pseudomallei Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-25 Juan Yao, Zhang Zhang, Hua Pei, Ting Zhang, Yuping Ruan, Chenyuan Liu, Yongcan Guo, Shuo Gu, Qianfeng Xia
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Massive field-of-view sub-cellular traction force videography enabled by Single-Pixel Optical Tracers (SPOT) Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Xing Haw Marvin Tan, Yijie Wang, Xiongfeng Zhu, Felipe Nanni Mendes, Pei-Shan Chung, Yu Ting Chow, Tianxing Man, Hsin Lan, Yen-Ju Lin, Xiang Zhang, Xiaohe Zhang, Thang Nguyen, Reza Ardehali, Michael A. Teitell, Arjun Deb, Pei-Yu Chiou
We report a massive field-of-view and high-speed videography platform for measuring the sub-cellular traction forces of more than 10,000 biological cells over 13 mm at 83 frames per second. Our Single-Pixel Optical Tracers (SPOT) tool uses 2-dimensional diffraction gratings embedded into a soft substrate to convert cells' mechanical traction force into optical colors detectable by a video camera. The
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Reduced graphene oxide electrodes meet lateral flow assays: A promising path to advanced point-of-care diagnostics Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Enric Calucho, Ruslan Álvarez-Diduk, Andrew Piper, Marianna Rossetti, Tarja K. Nevanen, Arben Merkoçi
Research in electrochemical detection in lateral flow assays (LFAs) has gained significant momentum in recent years. The primary impetus for this surge in interest is the pursuit of achieving lower limits of detection, especially given that LFAs are the most widely employed point-of-care biosensors. Conventionally, the strategy for merging electrochemistry and LFAs has centered on the superposition
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Lanthanide metal-organic framework-based surface molecularly imprinted polymers ratiometric fluorescence probe for visual detection of perfluorooctanoic acid with a smartphone-assisted portable device Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Yuanyuan Yang, Xiaohui Liu, Bofang Mu, Shuang Meng, Shun Mao, Wenquan Tao, Zhuo Li
Perfluorooctanoic acid (PFOA) poses a threat to the environment and human health due to its persistence, bioaccumulation, and reproductive toxicity. Herein, a lanthanide metal-organic framework (Ln-MOF)-based surface molecularly imprinted polymers (SMIPs) ratiometric fluorescence probe (Eu/Tb-MOF@MIPs) and a smartphone-assisted portable device were developed for the detection of PFOA with high selectivity
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Optimization and miniaturization of SE-ECL for potential-resolved, multi-color, multi-analyte detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Reza Abbasi, Sebastian Wachsmann-Hogiu
Electrochemiluminescence (ECL) is a bioanalytical technique with numerous advantages, including the potential for high temporal and spatial resolution, a high signal-to-noise ratio, a broad dynamic range, and rapid measurement capabilities. To reduce the complexity of a multi-electrode approach, we use a single-electrode electrochemiluminescence (SE-ECL) configuration to achieve the simultaneous emission
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Development of a CRISPR/Cas12a-mediated aptasensor for Mpox virus antigen detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Cong Han, Qirui Liu, Xuantong Luo, Jian Zhao, Zheng Zhang, Jiaxuan He, Feng Ge, Wei Ding, Zhaofeng Luo, Chao Jia, Liyun Zhang
The emergence and rapid spread of Mpox (formerly monkeypox) have caused significant societal challenges. Adequate and appropriate diagnostics procedures are an urgent necessity. Herein, we discover a pair of aptamers through the systematic evolution of ligands by exponential enrichment (SELEX) that exhibit high affinity and bind to different sites towards the A29 protein of the Mpox virus. Subsequently
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Time-encoded electrical detection of trace RNA biomarker by integrating programmable molecular amplifier on chip Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Gurpreet Kaur, Marcel Tintelott, Mohit Suranglikar, Antoine Masurier, Xuan-Thang Vu, Guillaume Gines, Yannick Rondelez, Sven Ingebrandt, Yannick Coffinier, Vivek Pachauri, Alexis Vlandas
One of the serious challenges facing modern point-of-care (PoC) molecular diagnostic platforms relate to reliable detection of low concentration biomarkers such as nucleic acids or proteins in biological samples. Non-specific analyte-receptor interactions due to competitive binding in the presence of abundant molecules, inefficient mass transport and very low number of analyte molecules in sample volume
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Ultra-sensitive and rapid detection of Salmonella enterica and Staphylococcus aureus to single-cell level by aptamer-functionalized carbon nanotube field-effect transistor biosensors Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Xiaoxuan Feng, Pengzhen Li, Tingxian Li, Xiaoling Cao, Daohe Liu, Mengmeng Xiao, Li Wang
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Electrospun EU/HPMC nanofibers decorated by ZIF-8 nanoparticle as the advanced electrochemical biosensor modifier for sensitive and selective detection of c-MET cancer biomarker in human plasma sample Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Fatemeh Maleki, Habib Razmi, Mohammad-Reza Rashidi, Mehdi Yousefi, Soghra Ramezani, Marjan Ghorbani
This research presents a selective and sensitive electrochemical biosensor for the detection of the mesenchymal–epithelial transition factor (c-MET). The biosensing is based on a modification of the SPCE (screen-printed carbon electrode) with the electrospun nanofiber containing eudragit (EU), hydroxypropyl methylcellulose (HPMC), and Zeolite imidazolate frameworks (ZIF-8) nanoparticles. EU/HPMC/ZIF-8
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In situ detection of dopamine in single living cells by molecularly imprinted polymer-functionalized nanoelectrodes Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-23 Cuiyu Zhou, Xiaoxue Xi, Xiong Liu, Wei Wen, Xiuhua Zhang, Zhen Wu, Shengfu Wang
In situ detection of dopamine (DA) at single-cell level is critical for exploring neurotransmitter-related biological processes and diseases. However, the low content of DA and a variety of distractors with similar oxidation potentials as DA in cells brought great challenges. Here, a sensitive and specific electrochemical nanosensor was proposed for in situ detection of DA in single living cells based
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A cell-free biosensor for multiplexed and sensitive detection of biological warfare agents Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-23 Yu Jin Park, Sunjoo Choi, Kyung Won Lee, So-Yoon Park, Dong-Yeon Song, Tae Hyeon Yoo, Dong-Myung Kim
The rapid and precise detection of pathogenic agents is critical for public health and societal stability. The detection of biological warfare agents (BWAs) is especially vital within military and counter-terrorism contexts, essential in defending against biological threats. Traditional methods, such as polymerase chain reaction (PCR), are limited by their need for specific settings, impacting their
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An instrument-free, integrated micro-platform for rapid and multiplexed detection of dairy adulteration in resource-limited environments Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-23 Nan Wang, Xiaoyun Sun, Juan Zhang, Ying Chen, Jiukai Zhang, Fengchun Huang, Ailiang Chen
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Sensing patches for biomarker identification in skin-derived biofluids Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Chen Wei, Danni Fu, Tianyue Ma, Mo Chen, Fangling Wang, Guojun Chen, Zejun Wang
In conventional clinical disease diagnosis and screening based on biomarker detection, most analysis samples are collected from serum, blood. However, these invasive collection methods require specific instruments, professionals, and may lead to infection risks. Additionally, the diagnosis process suffers from untimely results. The identification of skin-related biomarkers plays an unprecedented role
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A sensitive, portable, and smartphone-based whole-cell biosensor device for salicylic acid monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Nisha He, Qin Wei, Yiwen Li, Shantong Hu, Yufan Xian, Mo Yang, Pan Wu, Zhenghui Lu, Guimin Zhang
Considerable effort has been invested in developing salicylic acid (SA) biosensors for various application purposes. Here, by engineering the sensing modules and host cell chassis, we have gradually optimized the NahR-Psal/Pr-based SA biosensor, increasing the sensitivity and maximum output by 17.2-fold and 9.4-fold, respectively, and improving the detection limit by 800-fold, from 80 μM to 0.1 μM
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MOF-derived sandwich-structured dual Z-Scheme Co9S8@ZnIn2S4/CdSe hollow nanocages heterojunction: Target-induced ultrasensitive photoelectrochemical sensing of chlorpyrifos Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Ben-Fang Xu, Jin Zhang, Aisyah Protonia Tanjung, Fan Xu, Ai-Jun Wang, Li-Ping Mei, Pei Song, Jiu-Ju Feng
Exploring efficient photoactive material presents an intriguing opportunity to enhance the analytical performance of photoelectrochemical (PEC) sensor in the environmental analysis. In this work, a sandwich-structured multi-interface CoS@ZnInS/CdSe QDs dual Z-Scheme heterojunction, derived from metal-organic framework (MOF), was synthesized as a sensing platform for chlorpyrifos detection, by integrating
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Fluorescent metal nanoclusters: From luminescence mechanism to applications in enzyme activity assays Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Tong Wang, Hong-Sheng Tan, Ai-Jun Wang, Shan-Shan Li, Jiu-Ju Feng
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Culture-free detection of β-lactamase-Producing bacteria in urinary tract infections using a paper sensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Guangming Liu, Wenshuai Li, Siya Li, Jia Xu, Xinsheng Wang, Hua Xu, Dingbin Liu, Hongmei Gao
Developing simple, inexpensive, fast, sensitive, and specific probes for antibiotic-resistant bacteria is crucial for the management of urinary tract infections (UTIs). We here propose a paper-based sensor for the rapid detection of -lactamase-producing bacteria in the urine samples of UTI patients. By conjugating a strongly electronegative group –N(CH) with the core structures of cephalosporin and
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NIR-driven multifunctional PEC biosensor based on aptamer-modified PDA/MnO2 photoelectrode for bacterial detection and inactivation Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-20 Anni Cui, Lihua Dong, Yiting Hou, Xin Mu, Yu Sun, Huan Wang, Xiahua Zhong, Guiye Shan
Sensitive detection and effective inactivation of bacteria are essential in preventing foodborne bacterial infection that poses a significant threat to human health. Herein, a near-infrared (NIR)-driven multifunctional photoelectrochemical (PEC) biosensor was constructed for detection and inactivation of . Based on the covalent bonding between amine and carboxyl groups, carboxyl-functionalized SA31
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A dual-channel electrochemical biosensor enables concurrent detection of pathogens and antibiotic resistance Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-20 Dharanivasan Gunasekaran, Irina Rostovsky, David Taussig, Talya Bar-Am, Yariv Wine, Neta Sal-Man, Sefi Vernick
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Polymeric optical fiber biosensor with PAMAM dendrimer-based surface modification and PlGF detection for pre-eclampsia diagnosis Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-18 Ratan Kumar Chaudhary, Narayanan Madaboosi, Jitendra Satija, Balaji Nandagopal, Ramprasad Srinivasan, V.V.R. Sai
Pre-eclampsia (PE) is a life-threatening complication that occurs during pregnancy, affecting a large number of pregnant women and newborns worldwide. Rapid, on-site and affordable screening of PE at an early stage is necessary to ensure timely treatment and minimize both maternal and neonatal morbidity and mortality rates. Placental growth factor (PlGF) is an angiogenic blood biomarker used for PE
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Editorial note: Low temperature synthesis of carbon dots in microfluidic chip and their application for sensing cefquinome residues in milk [Biosens. Bioelectron. 228 (2023) 115187] Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-18 Guangming Li, Chen Liu, Xingcai Zhang, Peng Zhai, Xinyi Lai, Wenxiao Jiang
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Rational design of nanozyme with integrated sample pretreatment for colorimetric biosensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Jia Wu, Ling Liang, Shuishi Li, Yuan Qin, Shulin Zhao, Fanggui Ye
Nanozymes have been widely used in the field of biosensing owing to their high stability, low cost, adjustable catalytic activity, and convenient modification. However, achieving high selectivity and sensitivity simultaneously in nanozyme-based colorimetric sensing remains a major challenge. Nanozymes are nanomaterials with enzyme-simulating activity that are often used as solid-phase adsorbents for
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Vortexing-generated high throughput single-cell droplets for facile analysis of multiplexed microRNA dynamic secretion Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Fengjiao Zhu, Yangyang Long, Weiwei Shi, Bin Li, Yahui Ji, Xue Bai, Xianming Liu, Dongyuan Qi, Bo Sun, Fuyin Zhang, Tingjiao Liu, Bingcheng Lin, Yao Lu
Discriminating secretory phenotypes provides a direct, intact, and dynamic way to evaluate the heterogeneity in cell states and activation, which is significant for dissecting non-genetic heterogeneity for human health studies and disease diagnostics. In particular, secreted microRNAs, soluble signaling molecules released by various cells, are increasingly recognized as a critical mediator for cell-cell
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Recent advances in implantable sensors and electronics using printable materials for advanced healthcare Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Seunghyeb Ban, Haran Lee, Jiehao Chen, Hee-Seok Kim, Yuhang Hu, Seong J. Cho, Woon-Hong Yeo
This review article focuses on the recent printing technological progress in healthcare, underscoring the significant potential of implantable devices across diverse applications. Printing technologies have widespread use in developing health monitoring devices, diagnostic systems, and surgical devices. Recent years have witnessed remarkable progress in fabricating low-profile implantable devices,
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Paper-based loop-mediated isothermal amplification and CRISPR integrated platform for on-site nucleic acid testing of pathogens Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Anindita Sen, Manaswini Masetty, Sasanka Weerakoon, Calum Morris, Jagjit S. Yadav, Senu Apewokin, Jennifer Trannguyen, Murray Broom, Aashish Priye
We report the development and initial validation of a paper-based nucleic acid testing platform that integrates Loop-mediated isothermal amplification (LAMP) with clustered regularly interspaced short palindromic repeats (CRISPR) technology, referred to as PLACID (Paper-based LAMP-CRISPR Integrated Diagnostics). LAMP eliminates the need for thermal cycling, resulting in simplified instrumentation,
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Remote optogenetic control of the enteric nervous system and brain-gut axis in freely-behaving mice enabled by a wireless, battery-free optoelectronic device Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Andrew I. Efimov, Timothy J. Hibberd, Yue Wang, Mingzheng Wu, Kaiqing Zhang, Kaila Ting, Surabhi Madhvapathy, Min-Kyu Lee, Joohee Kim, Jiheon Kang, Mohammad Riahi, Haohui Zhang, Lee Travis, Emily J. Govier, Lianye Yang, Nigel Kelly, Yonggang Huang, Abraham Vázquez-Guardado, Nick J. Spencer, John A. Rogers
Wireless activation of the enteric nervous system (ENS) in freely moving animals with implantable optogenetic devices offers a unique and exciting opportunity to selectively control gastrointestinal (GI) transit , including the gut-brain axis. Programmed delivery of light to targeted locations in the GI-tract, however, poses many challenges not encountered within the central nervous system (CNS). We
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Rapid and sensitive parallel on-site detection of antibiotics and resistance genes in aquatic environments using evanescent wave dual-color fluorescence fiber-embedded optofluidic nanochip Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Dan Chen, Wenjuan Xu, Yongkai Lu, Yuxin Zhuo, Tianxiang Ji, Feng Long
Environmental antibiotics and antibiotic resistance genes (ARGs) pose considerable threat to humans and animals; thus, the rapid and sensitive parallel detection of these pollutants from a single sample is urgently required. However, traditional multiplexed analytic technologies detect only one type of target (e.g., small molecules or nucleic acids) per assay. To address this issue, Evanescent wave
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Combining deep learning and droplet microfluidics for rapid and label-free antimicrobial susceptibility testing of colistin Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Justine Riti, Guillaume Sutra, Thierry Naas, Hervé Volland, Stéphanie Simon, Karla Perez-Toralla
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A self-powered and supercapacitive microneedle continuous glucose monitoring system with a wide range of glucose detection capabilities Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Hye-Jun Kil, Jang Hyeon Kim, Kanghae Lee, Tae-Uk Kang, Ju-Hyun Yoo, Yong-ho Lee, Jin-Woo Park
Continuous detection of sudden changes in blood glucose is essential for individuals with diabetes who have difficulty in maintaining optimal control of their blood glucose levels. Hypoglycemic shock or a hyperglycemic crisis are likely to occurs in patients with diabetes and poses a significant threat to their lives. Currently, commercial continuous glucose monitoring (CGM) has limits in the glucose
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Highly sensitive humidity sensor based on composite film of partially reduced graphene oxide and bacterial cellulose Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Jingyi Song, Mingshuai Fan, Rui Zhang, Meijie Qu, Ping Tang, Hai Wang, Yuezhen Bin
Breathing is an important physiological activity of human body, which not only reflects the state of human movement, but also is one of the important health indicators. Breathing can change the concentration of water molecules, so monitoring humidity has gradually become a hot topic in modern research. In this study, a humidity sensing composite film with high sensitivity and short response time was
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Wearable smart contact lenses: A critical comparison of three physiological signals outputs for health monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Fei Han, Juju Li, Pingping Xiao, Yanshen Yang, Hao Liu, Zhao Wei, Yuan He, Feng Xu
Smart contact lenses (SCLs) have been considered as novel wearable devices for out-of-hospital and self-monitoring applications. They are capable of non-invasively and continuously monitoring physiological signals in the eyes, including vital biophysical (, intraocular of pressure, temperature, and electrophysiological signal) and biochemical signals (, pH, glucose, protein, nitrite, lactic acid, and
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Adaptively resettable microfluidic patch for sweat rate and electrolytes detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Mengyuan Liu, Siyuan Liu, Tong Zhang, Dengfeng Zhou, Lianhui Li, Qiang Gao, Yujie Liu, Changlei Ge, Yongfeng Wang, Mingxu Wang, Feng Wen, Zuoping Xiong, Zhen Zhou, Shuqi Wang, Ting Zhang
Skin-interfaced microfluidic patch has become a reliable device for sweat collection and analysis. However, the intractable problems of emptying the microchannel for reuse, and the channel's volumetric capacity limited by the size of the patch, directly hinder the practical application of sweat sensors. Herein, we report an adaptively resettable microfluidic sweat patch (Art-Sweat patch) capable of
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A rapid and sensitive one-pot platform integrating fluorogenic RNA aptamers and CRISPR-Cas13a for visual detection of monkeypox virus Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Xiao Wang, Xiaobao Deng, Yidun Zhang, Weiyi Dong, Qiao Rao, Qingmei Huang, Fei Tang, Rong Shen, Hongzhi Xu, Zhen Jin, Youzhi Tang, Dan Du
The recent global upsurge in Monkeypox virus (MPXV) outbreaks underscores the critical need for rapid and precise diagnostic solutions, particularly in resource-constrained settings. The gold standard diagnostic method, qRT-PCR, is hindered by its time-consuming nature, requirement for nucleic acid purification, expensive equipment, and the need for highly trained personnel. Traditional CRISPR/Cas
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Target proteins-regulated DNA nanomachine-electroactive substance complexes enable separation-free electrochemical detection of clinical exosome Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-14 Xianghu Zeng, Chengyong Wu, Ying Xiong, Zixuan Zhan, Congcong Shen, Feng Lin, Junlong Zhang, Piaopiao Chen
Simple and reliable profiling of tumor-derived exosomes (TDEs) holds significant promise for the early detection of cancer. Nonetheless, this remains challenging owing to the substantial heterogeneity and low concentration of TDEs. Herein, we devised an accurate and highly sensitive electrochemical sensing strategy for TDEs simultaneously targeting exosomal mucin 1 (MUC1) and programmed cell death