Proper customization in size and shape is essential in implantable bioelectronics for stable bio-signal recording. Over the past decades, many researchers have heavily relied on conventional photolithography processes to fabricate implantable bioelectronics. Therefore, they could not avoid the critical limitation of high cost and complex processing steps to optimize bioelectronic devices for target organs with various sizes and shapes. Here, we propose rapid prototyping using all laser processes to fabricate customized bioelectronics. PEDOT:PSS is selectively irradiated by an ultraviolet (UV) pulse laser to form wet-stable conductive hydrogels that can softly interact with biological tissues (50 μm line width). The encapsulation layer is selectively patterned using the same laser source by UV-curing polymer networks (110 μm line width). For high stretchability (over 100%), mesh structures are made by the selective laser cutting process. Our rapid prototyping strategy minimizes the use of high-cost equipment, using only a single UV laser source to process the electrodes, encapsulation, and substrates that constitute bioelectronics without a photomask, enabling the prototyping stretchable microelectrode array with an area of 1 cm less than 10 min. We fabricated an optimized stretchable microelectrode array with low impedances (∼1.1 kΩ at 1 kHz) that can effectively record rat's cardiac signals with various health states.

中文翻译：

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基于全激光工艺的导电水凝胶生物电子学的快速原型制作和轻松定制


在植入式生物电子学中，尺寸和形状的适当定制对于稳定的生物信号记录至关重要。在过去的几十年里，许多研究人员严重依赖传统的光刻工艺来制造可植入生物电子学。因此，他们无法避免高成本和复杂处理步骤的关键限制，以优化各种尺寸和形状的目标器官的生物电子设备。在这里，我们建议使用所有激光工艺进行快速原型制作来制造定制的生物电子学。 PEDOT:PSS 通过紫外线 (UV) 脉冲激光选择性照射，形成湿稳定的导电水凝胶，可以与生物组织轻柔地相互作用（50 μm 线宽）。使用相同的激光源通过紫外线固化聚合物网络（110 μm 线宽）对封装层进行选择性图案化。为了实现高拉伸性（超过 100%），网状结构是通过选择性激光切割工艺制成的。我们的快速原型设计策略最大限度地减少了高成本设备的使用，仅使用单个紫外激光源即可加工构成生物电子学的电极、封装和基板，无需使用光掩模，从而能够原型制作出面积小于 1 cm 的可拉伸微电极阵列。 10 分钟我们制造了一种优化的低阻抗可拉伸微电极阵列（1kHz 时~1.1kΩ），可以有效记录各种健康状态下的大鼠心脏信号。