Real-time monitoring of biological markers in sweat is a valuable tool for health assessment. In this study, we have developed an innovative wearable biosensor for precise analysis of glucose in sweat during physical activities. The sensor is based on a single-atom catalyst of platinum (Pt) uniformly dispersed on tricobalt tetroxide (CoO) nanorods and reduced graphene oxide (rGO), featuring a unique three-dimensional nanostructure and excellent glucose electrocatalytic performance with a wide detection range of 1–800 μM. Additionally, density functional theory calculations have revealed the synergetic role of Pt active sites in the Pt single-atom catalyst (CoO/rGO/Pt) in glucose adsorption and electron transfer, thereby enhancing sensor performance. To enable application in wearable devices, we designed an S-shaped microfluidic chip and a point-of-care testing (POCT) device, both of which were validated for effectiveness through actual use by volunteers. This research provides valuable insights and innovative approaches for analyzing sweat glucose using wearable devices, contributing to the advancement of personalized healthcare.

中文翻译：

---

通过 Pt 单原子催化剂协同增强可穿戴生物传感器用于汗液分析


实时监测汗液中的生物标记物是健康评估的重要工具。在这项研究中，我们开发了一种创新的可穿戴生物传感器，用于精确分析体育活动期间汗液中的葡萄糖。该传感器基于均匀分散在四氧化三钴（CoO）纳米棒和还原氧化石墨烯（rGO）上的铂（Pt）单原子催化剂，具有独特的三维纳米结构和优异的葡萄糖电催化性能，具有较宽的检测范围1–800 μM。此外，密度泛函理论计算揭示了Pt单原子催化剂（CoO/rGO/Pt）中Pt活性位点在葡萄糖吸附和电子转移中的协同作用，从而提高了传感器性能。为了实现在可穿戴设备中的应用，我们设计了S形微流控芯片和即时检测（POCT）设备，这两种设备都通过志愿者的实际使用验证了有效性。这项研究为使用可穿戴设备分析汗液葡萄糖提供了宝贵的见解和创新方法，有助于推动个性化医疗保健的进步。