In biological systems, nucleosides play crucial roles in various physiological processes. In this study, we designed and synthesized four achiral anthracene-based tetracationic nanotubes (–) as artificial hosts and chiroptical sensors for nucleosides in aqueous media. Notably, different nanotubes exhibit varied chirality sensing on circular dichroism (CD)/circularly polarized luminescence (CPL) spectra through the host-guest complexation, which prompted us to explore the factors influencing their chiroptical responses. Through systematic host-guest experiments, the structure-chirality sensing relationship between achiral anthracene-based tetracationic nanotubes and nucleosides in the host-guest complexation was unraveled. Firstly, the CD response originates from the anthracene rings situated at the side-wall position, resulting from the right-handed (- or left-handed (-twisted conformation of the macrocyclic structure. Secondly, the CPL signal is influenced by the presence of anthracene rings at the linking-wall position, which results from intermolecular chiral twisted stacking between these anthracene rings. Therefore, these nanotubes can serve as chiroptical sensor arrays to enhance the accuracy of nucleotide recognition through principal component analysis (PCA) analysis based on the diversified CD spectra. This study provides insights for the construction of adaptive chirality from achiral nanotubes with dynamic conformational nature and might facilitate further design of chiral functional materials for several applications.

中文翻译：

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揭示水性主客体络合中非手性蒽基四阳离子纳米管与核苷之间的结构-手性传感关系


在生物系统中，核苷在各种生理过程中发挥着至关重要的作用。在这项研究中，我们设计并合成了四种非手性蒽基四阳离子纳米管（-）作为水介质中核苷的人工宿主和手性光学传感器。值得注意的是，不同的纳米管通过主客体络合作用在圆二色性（CD）/圆偏振发光（CPL）光谱上表现出不同的手性传感，这促使我们探索影响其手性光学响应的​​因素。通过系统的主客体实验，揭示了主客体络合中非手性蒽基四阳离子纳米管与核苷之间的结构-手性传感关系。首先，CD响应源自位于侧壁位置的蒽环，这是由大环结构的右手（-或左手（-）扭曲构象产生的）。其次，CPL信号受到存在的影响蒽环位于连接壁位置，这是由于这些蒽环之间的分子间手性扭曲堆积而产生的，因此，这些纳米管可以作为手性光学传感器阵列，通过基于多样化的主成分分析（PCA）分析来提高核苷酸识别的准确性。 CD光谱。这项研究为从具有动态构象性质的非手性纳米管构建自适应手性提供了见解，并可能有助于进一步设计用于多种应用的手性功能材料。