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Regulating tumor innervation by nanodrugs potentiates cancer immunochemotherapy and relieve chemotherapy-induced neuropathic pain Biomaterials (IF 14.0) Pub Date : 2024-05-03 Shuting Zuo, Zhenyu Wang, Xiaoman Jiang, Yuewu Zhao, Panyue Wen, Jine Wang, Junjie Li, Masaru Tanaka, Shao Dan, Yan Zhang, Zheng Wang
Sympathetic nerves play a pivotal role in promoting tumor growth through crosstalk with tumor and stromal cells. Chemotherapy exacerbates the infiltration of sympathetic nerves into tumors, thereby providing a rationale for inhibiting sympathetic innervation to enhance chemotherapy. Here, we discovered that doxorubicin increases the density and activity of sympathetic nerves in breast cancer mainly
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Structure driven bio-responsive ability of injectable nanocomposite hydrogels for efficient bone regeneration Biomaterials (IF 14.0) Pub Date : 2024-05-02 Tao Song, Fengxin Zhao, Ling Yan, Puxin Liu, Jirong Yang, Changshun Ruan, Dongxiao Li, Yumei Xiao, Xingdong Zhang
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3D-Printed proangiogenic patches of photo-crosslinked gelatin and polyurethane hydrogels laden with vascular cells for treating vascular ischemic diseases Biomaterials (IF 14.0) Pub Date : 2024-04-30 Yu-Tsung Shih, Kun-Chih Cheng, Yi-Ju Ko, Chia-Yu Lin, Mei-Cun Wang, Chih-I Lee, Pei-Ling Lee, Rong Qi, Jeng-Jiann Chiu, Shan-hui Hsu
Engineering vascularized tissues remains a promising approach for treating ischemic cardiovascular diseases. The availability of 3D-bioprinted vascular grafts that induce therapeutic angiogenesis can help avoid necrosis and excision of ischemic tissues. Here, using a combination of living cells and biodegradable hydrogels, we fabricated 3D-printed biocompatible proangiogenic patches from endothelial
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Zwitterionic modified and freeze-thaw reinforced foldable hydrogel as intraocular lens for posterior capsule opacification prevention Biomaterials (IF 14.0) Pub Date : 2024-04-30 Cheng-Jui Yang, Wei-Lun Huang, Yu Yang, Chen-Hsiang Kuan, Ching-Li Tseng, Tzu-Wei Wang
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Co-delivery of Plinabulin and Tirapazamine boosts anti-tumor efficacy by simultaneously destroying tumor blood vessels and killing tumor cells Biomaterials (IF 14.0) Pub Date : 2024-04-30 Jianlin Lv, Yajun Xu, Ya Liu, Kazuo Sakurai, Haiyang Yu, Zhaohui Tang
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pH-responsive bioadhesive with robust and stable wet adhesion for gastric ulcer healing Biomaterials (IF 14.0) Pub Date : 2024-04-30 Ruilin Xie, Xueli Yan, Jing Yu, Kaixiang Shen, Mengyuan Zhang, Meng Li, Zhuting Lv, Yuchen Zhang, Zixi Zhang, Yi Lyu, Yilong Cheng, Dake Chu
Development of bioadhesives that can be facilely delivered by endoscope and exhibit instant and robust adhesion with gastric tissues to promote gastric ulcer healing remains challenging. In this study, an advanced bioadhesive is prepared through free radical polymerization of ionized N-acryloyl phenylalanine (iAPA) and N-[tris (hydroxymethyl) methyl] acrylamide (THMA). The precursory polymer solution
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Trehalose-based coacervates for local bioactive protein delivery to the central nervous system Biomaterials (IF 14.0) Pub Date : 2024-04-27 Laboni F. Hassan, Riya Sen, Timothy M. O'Shea
Therapeutic outcomes of local biomolecule delivery to the central nervous system (CNS) using bulk biomaterials are limited by inadequate drug loading, neuropil disruption, and severe foreign body responses. Effective CNS delivery requires addressing these issues and developing well-tolerated, highly-loaded carriers that are dispersible within local neural parenchyma. Here, we synthesized biodegradable
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Microenvironment-sensitive nanozymes for tissue regeneration Biomaterials (IF 14.0) Pub Date : 2024-04-27 Yuan Xiong, Bobin Mi, Guohui Liu, Yanli Zhao
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Transformation of metallo-elastomer grafts in a carotid artery interposition model over a year Biomaterials (IF 14.0) Pub Date : 2024-04-26 Ying Grace Chen, Catia Dombaxe, Anthony Richard D'Amato, Simon Van Herck, Halle Welch, Qin Fu, Sheng Zhang, Yadong Wang
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Dynamic injectable tissue adhesives with strong adhesion and rapid self-healing for regeneration of large muscle injury Biomaterials (IF 14.0) Pub Date : 2024-04-26 Sungmin Nam, Junzhe Lou, Sangmin Lee, Jan-Marc Kartenbender, David J. Mooney
Wounds often necessitate the use of instructive biomaterials to facilitate effective healing. Yet, consistently filling the wound and retaining the material in place presents notable challenges. Here, we develop a new class of injectable tissue adhesives by leveraging the dynamic crosslinking chemistry of Schiff base reactions. These adhesives demonstrate outstanding mechanical properties, especially
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Photosensitive AIEgens sensitize bacteria to oxidative damage and modulate the inflammatory responses of macrophages to salvage the photodynamic therapy against MRSA Biomaterials (IF 14.0) Pub Date : 2024-04-26 Yifan Wu, Jiangao Li, Liwei Zhu, Deliang Wang, Jiayi Song, Xiyong Yu, Ying Li, Ben Zhong Tang
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Corrigendum to ‘Engineered cell-laden human protein-based elastomer’ [34 (2013), 5496–5505] Biomaterials (IF 14.0) Pub Date : 2024-04-24 Nasim Annabi, Suzanne M. Mithieux, Pinar Zorlutuna, Gulden Camci-Unal, Anthony S. Weiss, Ali Khademhosseini
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Mucus-coated, magnetically-propelled fecal surrogate to mimic fecal shear forces on colonic epithelium Biomaterials (IF 14.0) Pub Date : 2024-04-23 Alan S. Wang, Cecilia Villegas-Novoa, Yuli Wang, Christopher E. Sims, Nancy L. Allbritton
The relationship between the mechanical forces associated with bowel movement and colonic mucosal physiology is understudied. This is partly due to the limited availability of physiologically relevant fecal models that can exert these mechanical stimuli in colon models in a simple-to-implement manner. In this report, we created a mucus-coated fecal surrogate that was magnetically propelled to produce
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Wireless breathable face mask sensor for spatiotemporal 2D respiration profiling and respiratory diagnosis Biomaterials (IF 14.0) Pub Date : 2024-04-22 Jaehyun Kim, Heesung Roh, Sungmin Moon, Cheonhoo Jeon, Seunggoo Baek, Woosung Cho, Jae-Yoon Sim, Unyong Jeong
Owing to air pollution and the pandemic outbreak, the need for quantitative pulmonary monitoring has greatly increased. The COVID-19 outbreak has aroused attention for comfortable wireless monitoring of respiratory profiles and more real-time diagnosis of respiratory diseases. Although respiration sensors have been investigated extensively with single-pixel sensors, 2D respiration profiling with a
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A ferroptosis amplifier based on triple-enhanced lipid peroxides accumulation strategy for effective pancreatic cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-04-21 Mengyao Chen, Xiaohan Tong, Yanting Sun, Chunyan Dong, Chen Li, Chunhui Wang, Minyi Zhang, Yixuan Wen, Pinting Ye, Ruihao Li, Jie Wan, Shujing Liang, Shuo Shi
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In vitro models for studying implant-associated biofilms - A review from the perspective of bioengineering 3D microenvironments Biomaterials (IF 14.0) Pub Date : 2024-04-20 Silvia Cometta, Dietmar W. Hutmacher, Liraz Chai
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Trehalose enhanced cold atmospheric plasma-mediated cancer treatment Biomaterials (IF 14.0) Pub Date : 2024-04-18 Xiaona Cao, Tianxu Fang, Mo Chen, Tianqin Ning, Jianyu Li, Peter M. Siegel, Morag Park, Zhitong Chen, Guojun Chen
Cold atmospheric plasma (CAP) is a unique form of physical plasma that has shown great potential for cancer therapy. CAP uses ionized gas to induce lethal oxidative stress on cancer cells; however, the efficacy of CAP therapy continues to be improved. Here, we report an injectable hydrogel-mediated approach to enhance the anti-tumor efficacy of CAP by regulating the phosphorylation of eIF2α. We discovered
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Deciphering platinum dissolution in neural stimulation electrodes: Electrochemistry or biology? Biomaterials (IF 14.0) Pub Date : 2024-04-17 Dhyey Devashish Shah, Paul Carter, Mohit Naresh Shivdasani, Nicole Fong, Wenlu Duan, Dorna Esrafilzadeh, Laura Anne Poole-Warren, Ulises Alejandro Aregueta Robles
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Polymeric micellar nanoparticles for effective CRISPR/Cas9 genome editing in cancer Biomaterials (IF 14.0) Pub Date : 2024-04-17 Yuzhen Li, Chun Li, Jiachang Yan, Ying Liao, Chengyuan Qin, Lingyin Wang, Yi Huang, Chuan Yang, Jianwei Wang, Xin Ding, Yi Yan Yang, Peiyan Yuan
The clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9) gene editing has attracted extensive attentions in various fields, however, its clinical application is hindered by the lack of effective and safe delivery system. Herein, we reported a cationic micelle nanoparticle composed of cholesterol-modified branched small molecular PEI (PEI-CHO) and biodegradable
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Beyond surface modification strategies to control infections associated with implanted biomaterials and devices - Addressing the opportunities offered by nanotechnology Biomaterials (IF 14.0) Pub Date : 2024-04-16 Da-Yuan Wang, Linzhu Su, Kees Poelstra, David W. Grainger, Henny C. van der Mei, Linqi Shi, Henk J. Busscher
Biomaterial-associated infection (BAI) is considered a unique infection due to the presence of a biomaterial yielding frustrated immune-cells, ineffective in clearing local micro-organisms. The involvement of surface-adherent/surface-adapted micro-organisms in BAI, logically points to biomaterial surface-modifications for BAI-control. Biomaterial surface-modification is most suitable for prevention
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Hierarchical self-recognition and response in CSC and non-CSC micro-niches for cancer therapy Biomaterials (IF 14.0) Pub Date : 2024-04-15 Yiliang Yang, Yiwei Peng, Yitian Du, Meng Lin, Jiajia Li, Datong Gao, Zhenzhen Yang, Wei Wang, Yanxia Zhou, Xinru Li, Taiqiang Yan, Xianrong Qi
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Implantable CAR T cell factories enhance solid tumor treatment Biomaterials (IF 14.0) Pub Date : 2024-04-15 Sharda Pandit, Pritha Agarwalla, Feifei Song, Anton Jansson, Gianpietro Dotti, Yevgeny Brudno
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Gram-negative bacteria recognition and photodynamic elimination by Zn-DPA based sensitizers Biomaterials (IF 14.0) Pub Date : 2024-04-15 Zuokai Wang, Shuang Zeng, Yifu Hao, Wenlin Cai, Wen Sun, Jianjun Du, Saran Long, Jiangli Fan, Jingyun Wang, Xiaoqiang Chen, Xiaojun Peng
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NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN-γ released Biomaterials (IF 14.0) Pub Date : 2024-04-15 Junrui Wang, Wenli Zhang, Zhuoyan Xie, Xingyue Wang, Jiangshan Sun, Fei Ran, Weixi Jiang, Yun Liu, Zhigang Wang, Haitao Ran, Dajing Guo
Metallic biomaterials activate tumor ferroptosis by increasing oxidative stress, but their efficacy is severely limited in tumor microenvironment. Although interferon gamma (IFN-γ) can promote tumor ferroptosis sensitivity by inhibiting the antioxidant system and promoting lipid accumulation, this effect limited by the lack of IFN-γ accumulation in tumors. Herein, we report a near-infrared (NIR)-responsive
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Optical controlled and nuclear targeted CECR2 competitor to downregulate CSF-1 for metastatic breast cancer immunotherapy Biomaterials (IF 14.0) Pub Date : 2024-04-12 Yi Cen, Ying Chen, Xinxuan Li, Xiayun Chen, Baixue Yu, Mengyi Yan, Ni Yan, Hong Cheng, Shiying Li
The crosstalk between breast cancer cells and tumor associated macrophages (TAMs) greatly contributes to tumor progression and immunosuppression. In this work, cat eye syndrome chromosome region candidate 2 (CECR2) is identified to overexpress in breast cancer patients, which can recognize v-rel avian reticuloendotheliosis viral oncogene homolog A (RelA) and activate nuclear factor κB (NF-κB) to release
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The orientation of CpG conjugation on aluminum oxyhydroxide nanoparticles determines the immunostimulatory effects of combination adjuvants Biomaterials (IF 14.0) Pub Date : 2024-04-11 Zhihui Liang, Hang Bao, Zhiying Yao, Min Li, Chen Chen, Lei Zhang, Huiyang Wang, Yiyang Guo, Yubin Ma, Xuecheng Yang, Ge Yu, Jiancheng Zhang, Changying Xue, Bingbing Sun, Chuanbin Mao
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Synergistic large segmental bone repair by 3D printed bionic scaffolds and engineered ADSC nanovesicles: Towards an optimized regenerative microenvironment Biomaterials (IF 14.0) Pub Date : 2024-04-08 Wenbin Jiang, Yichen Zhan, Yifan Zhang, Di Sun, Guo Zhang, Zhenxing Wang, Lifeng Chen, Jiaming Sun
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Intranasal delivery of low-dose anti-CD124 antibody enhances treatment of chronic rhinosinusitis with nasal polyps Biomaterials (IF 14.0) Pub Date : 2024-04-06 Jiamin Wu, Natalie Jones, Po-Han Chao, Vanessa Chan, Lukas Hohenwarter, Angeline Wu, Marta Bergamo, Cristina Rodríguez-Rodríguez, Katayoun Saatchi, Alex Liang, Urs O. Häfeli, Zheng Tan, Sarah Hedtrich, Lucas J. Andrew, Shyh-Dar Li
Frequent injections of anti-CD124 monoclonal antibody (αCD124) over long periods of time are used to treat chronic rhinosinusitis with nasal polyps (CRSwNP). Needle-free, intranasal administration (i.n.) of αCD124 is expected to provide advantages of localized delivery, improved efficacy, and enhanced medication adherence. However, delivery barriers such as the mucus and epithelium in the nasal tissue
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Biomimetic and multifunctional nanocomposites for precision fungi theranostics Biomaterials (IF 14.0) Pub Date : 2024-04-04 Li Wang, Yueyue Gui, Kexin Li, Wei Tao, Chao Li, Jin Qiu, Jiehua Ma
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Optimization of lipid nanoparticles for gene editing of the liver via intraduodenal delivery Biomaterials (IF 14.0) Pub Date : 2024-04-04 Yining Zhu, Shuting Sarah Cai, Jingyao Ma, Leonardo Cheng, Christine Wei, Ataes Aggarwal, Wu Han Toh, Charles Shin, Ruochen Shen, Jiayuan Kong, Shuming Alan Mao, Yeh-Hsing Lao, Kam W. Leong, Hai-Quan Mao
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Nitroreductase-responsive nanoparticles for in situ fluorescence imaging and synergistic antibacterial therapy of bacterial keratitis Biomaterials (IF 14.0) Pub Date : 2024-04-03 Jing Xiang, Ruifen Zou, Pin Wang, Xinfangzi Wang, Xuefei He, Fang Liu, Chen Xu, Aiguo Wu
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Microfluidic-based multifunctional microspheres for enhanced oral co-delivery of probiotics and postbiotics Biomaterials (IF 14.0) Pub Date : 2024-04-03 Xinyuan Yang, Weimin Nie, Chong Wang, Zhonglin Fang, Luoran Shang
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Exosome/antimicrobial peptide laden hydrogel wound dressings promote scarless wound healing through miR-21-5p-mediated multiple functions Biomaterials (IF 14.0) Pub Date : 2024-04-02 YuLing Yang, JiaNi Zhang, SiWen Wu, Yu Deng, ShiHan Wang, Li Xie, XiaoPeng Li, Li Yang
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Engineered extracellular vesicle-based gene therapy for the treatment of discogenic back pain Biomaterials (IF 14.0) Pub Date : 2024-04-01 Shirley N. Tang, Ana I. Salazar-Puerta, Mary K. Heimann, Kyle Kuchynsky, María A. Rincon-Benavides, Mia Kordowski, Gilian Gunsch, Lucy Bodine, Khady Diop, Connor Gantt, Safdar Khan, Anna Bratasz, Olga Kokiko-Cochran, Julie Fitzgerald, Damien M. Laudier, Judith A. Hoyland, Benjamin A. Walter, Natalia Higuita-Castro, Devina Purmessur
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Engineering fibronectin-templated multi-component fibrillar extracellular matrices to modulate tissue-specific cell response Biomaterials (IF 14.0) Pub Date : 2024-04-01 Seungkuk Ahn, Akanksha Jain, Krishna Chaitanya Kasuba, Makiko Seimiya, Ryoko Okamoto, Barbara Treutlein, Daniel J. Müller
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Vaso-Lock for sutureless anastomosis in a pig arteriovenous loop model Biomaterials (IF 14.0) Pub Date : 2024-04-01 Xiaowei Li, Emma R. Young, Cameron Martin, Joseph G. Ribaudo, Mohamed Zaghloul, Sophia Roberts, Rodrigo Meade, Batool Arif, William R. Moritz, Sarah Madira, Jonathon B. Schofield, Helen Xun, Caitlin W. Hicks, Sung H. Kang, Mohamed A. Zayed, Justin M. Sacks
A vascular anastomosis is a critical surgical skill that involves connecting blood vessels. Traditional handsewn techniques can be challenging and resource intensive. To address these issues, we have developed a unique sutureless anastomotic device called Vaso-Lock. This intraluminal device connects free vascular ends using anchors to maintain traction and enable a rapid anastomosis. We tested the
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Exosomes based strategies for cardiovascular diseases: Opportunities and challenges Biomaterials (IF 14.0) Pub Date : 2024-03-31 Hang Li, Jun Zhang, Mingyue Tan, Yunfei Yin, Yiyi Song, Yongjian Zhao, Lin Yan, Ning Li, Xianzuo Zhang, Jiaxiang Bai, Tingbo Jiang, Hongxia Li
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Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity Biomaterials (IF 14.0) Pub Date : 2024-03-29 Wan-Yu Chiang, Helen Wenshin Yu, Ming-Chung Wu, Yi-Man Huang, Yin-Quan Chen, Jong-Wei Lin, Yen-Wenn Liu, Li-Ru You, Arthur Chiou, Jean-Cheng Kuo
Sarcopenia, a prevalent muscle disease characterized by muscle mass and strength reduction, is associated with impaired skeletal muscle regeneration. However, the influence of the biomechanical properties of sarcopenic skeletal muscle on the efficiency of the myogenic program remains unclear. Herein, we established a mouse model of sarcopenia and observed a reduction in stiffness within the sarcopenic
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Bispecific fibrous glue synergistically boosts vascular normalization and antitumor immunity for advanced renal carcinoma therapy Biomaterials (IF 14.0) Pub Date : 2024-03-28 Xiu-Hai Wu, Jia-Qi Wang, Man-Di Wang, Ting Xiao, Yu Wang, Jia-Yuan Niu, Lu Wang, Da-Yong Hou, Bo Fu, Zimo Liu, Hao Wang, Wanhai Xu
Immune checkpoint blockade therapy represented by programmed cell death ligand 1 (PD-L1) inhibitor for advanced renal carcinoma with an objective response rate (ORR) in patients is less than 20%. It is attributed to abundant tumoral vasculature with abnormal structure limiting effector T cell infiltration and drug penetration. We propose a bispecific fibrous glue (BFG) to regulate tumor immune and
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Sentinel lymph node identification using NIR-II ultrabright Raman nanotags on preclinical models Biomaterials (IF 14.0) Pub Date : 2024-03-27 Binge Deng, Yan Wang, Xiangdong Bu, Jin Li, Jingsong Lu, Linley Li Lin, Yaohui Wang, Yao Chen, Jian Ye
Surface-enhanced Raman spectroscopy (SERS) nanotags have garnered much attention as promising bioimaging contrast agent with ultrahigh sensitivity, but their clinical translation faces challenges including biological and laser safety. As breast sentinel lymph node (SLN) imaging agents, SERS nanotags used by local injection and only accumulation in SLNs, which were removed during surgery, greatly reduce
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From hemostasis to proliferation: Accelerating the infected wound healing through a comprehensive repair strategy based on GA/OKGM hydrogel loaded with MXene@TiO2 nanosheets Biomaterials (IF 14.0) Pub Date : 2024-03-27 Xingan Qiu, Linxia Nie, Pei Liu, Xiaojiang Xiong, Fangye Chen, Xuezhe Liu, Pengzhen Bu, Bikun Zhou, Meijun Tan, Fangbiao Zhan, Xiufeng Xiao, Qian Feng, Kaiyong Cai
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A functional 3D full-thickness model for comprehending the interaction between airway epithelium and connective tissue in cystic fibrosis Biomaterials (IF 14.0) Pub Date : 2024-03-26 Claudia Mazio, Laura Sara Scognamiglio, Costantino Casale, Valeria Panzetta, Francesco Urciuolo, Luis J.V. Galietta, Giorgia Imparato, Paolo A. Netti
Patients with cystic fibrosis (CF) experience severe lung disease, including persistent infections, inflammation, and irreversible fibrotic remodeling of the airways. Although therapy with transmembrane conductance regulator (CFTR) protein modulators reached optimal results in terms of CFTR rescue, lung transplant remains the best line of care for patients in an advanced stage of CF. Indeed, chronic
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Overcoming antibiotic resistance caused by genetic mutations of Helicobacter pylori with mucin adhesive polymer-based therapeutics Biomaterials (IF 14.0) Pub Date : 2024-03-25 Byoungjun Lim, Kyoung Sub Kim, Ji Yong Ahn, Kun Na
Herein, we describe the 3′-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria () within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3′-sialyllactose, which exhibits a specific binding affinity for surface proteins, and a photosensitizer capable of generating oxygen radicals
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Design and development of novel self-assembled catechol-modified bile acid conjugates as pH-responsive apical sodium-dependent bile acid transporter targeting nanoparticles Biomaterials (IF 14.0) Pub Date : 2024-03-24 Dong-Nyeong Lee, Seong-Bin Yang, Seho Kweon, Jun-Hyuck Lee, Kyeong-Ju Lee, Yeonsu Ryu, Dong Wook Shin, Young Jun Kim, Yong-Kyu Lee, Jooho Park
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Engineered human osteoarthritic cartilage organoids Biomaterials (IF 14.0) Pub Date : 2024-03-22 Laura Dönges, Atharva Damle, Andrea Mainardi, Thomas Bock, Monica Schönenberger, Ivan Martin, Andrea Barbero
The availability of human cell-based models capturing molecular processes of cartilage degeneration can facilitate development of disease-modifying therapies for osteoarthritis [1], a currently unmet clinical need. Here, by imposing specific inflammatory challenges upon mesenchymal stromal cells at a defined stage of chondrogenesis, we engineered a human organotypic model which recapitulates main OA
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Multi-step strategies for synergistic treatment of urinary tract infections based on D-xylose-decorated antimicrobial peptide carbon dots Biomaterials (IF 14.0) Pub Date : 2024-03-22 Chunhui Miao, Yajie Zhang, Guowen Liu, Jianming Yang, Kaiyuan Yu, Junqiang Lv, Ran Liu, Zhi Yao, Yuanjie Niu, Xiaojuan Wang, Quan Wang
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Biomaterial-mediated intracellular control of macrophages for cell therapy in pro-inflammatory and pro-fibrotic conditions Biomaterials (IF 14.0) Pub Date : 2024-03-22 Tina Tylek, Joanna Wong, Andrew E. Vaughan, Kara L. Spiller
Macrophages are key modulators of all inflammatory diseases and essential for their resolution, making macrophage cell therapy a promising strategy for regenerative medicine. However, since macrophages change rapidly in response to microenvironmental cues, their phenotype must be controlled post-administration. We present a tunable biomaterial-based strategy to control macrophages intracellularly via
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Planar amorphous silicon carbide microelectrode arrays for chronic recording in rat motor cortex Biomaterials (IF 14.0) Pub Date : 2024-03-21 Justin R. Abbott, Eleanor N. Jeakle, Pegah Haghighi, Joshua O. Usoro, Brandon S. Sturgill, Yupeng Wu, Negar Geramifard, Rahul Radhakrishna, Sourav Patnaik, Shido Nakajima, Jordan Hess, Yusef Mehmood, Veda Devata, Gayathri Vijayakumar, Armaan Sood, Teresa Thuc Doan Thai, Komal Dogra, Ana G. Hernandez-Reynoso, Joseph J. Pancrazio, Stuart F. Cogan
Chronic implantation of intracortical microelectrode arrays (MEAs) capable of recording from individual neurons can be used for the development of brain-machine interfaces. However, these devices show reduced recording capabilities under chronic conditions due, at least in part, to the brain's foreign body response (FBR). This creates a need for MEAs that can minimize the FBR to possibly enable long-term
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An all-in-one therapeutic platform for the treatment of resistant Helicobacter pylori infection Biomaterials (IF 14.0) Pub Date : 2024-03-21 Chao Sun, Jia Huang, Xiaoqian Guo, Chenli Zhang, Li Wei, Ka Ioi Wong, Ziyun Yang, Gang Zhao, Min Lu, Weiyan Yao
() infection is a major cause of gastric diseases. Currently, bismuth-based quadruple therapy is widely adopted for eradicating infection. However, this first-line strategy faces several challenges such as drug resistance, intestinal dysbacteriosis, and patients’ poor compliance. To overcome these problems, an all-in-one therapeutic platform (CLA-Bi-ZnO@Lipo) that composed of liposomes loading clarithromycin
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Mammary tissue-derived extracellular matrix hydrogels reveal the role of irradiation in driving a pro-tumor and immunosuppressive microenvironment Biomaterials (IF 14.0) Pub Date : 2024-03-21 Tian Zhu, Steven M. Alves, Arianna Adamo, Xiaona Wen, Kevin C. Corn, Anastasia Shostak, Shereena Johnson, Nicholas D. Shaub, Shannon E. Martello, Benjamin C. Hacker, Antonio D'Amore, Rizia Bardhan, Marjan Rafat
Radiation therapy (RT) is essential for triple negative breast cancer (TNBC) treatment. However, patients with TNBC continue to experience recurrence after RT. The role of the extracellular matrix (ECM) of irradiated breast tissue in tumor recurrence is still unknown. In this study, we evaluated the structure, molecular composition, and mechanical properties of irradiated murine mammary fat pads (MFPs)
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Membrane-anchoring selenophene viologens for antibacterial photodynamic therapy against periodontitis via restoring subgingival flora and alleviating inflammation Biomaterials (IF 14.0) Pub Date : 2024-03-21 Rui Ding, Xu Liu, Xiaodan Zhao, Qi Sun, Yilong Cheng, Ang Li, Dandan Pei, Gang He
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FAK, vinculin, and talin control mechanosensitive YAP nuclear localization Biomaterials (IF 14.0) Pub Date : 2024-03-20 Elijah N. Holland, Marc A. Fernández-Yagüe, Dennis W. Zhou, Eric B. O'Neill, Ayanna U. Woodfolk, Ana Mora-Boza, Jianping Fu, David D. Schlaepfer, Andrés J. García
Focal adhesions (FAs) are nanoscale complexes containing clustered integrin receptors and intracellular structural and signaling proteins that function as principal sites of mechanotransduction in part via promoting the nuclear translocation and activation of the transcriptional coactivator yes-associated protein (YAP). Knockdown of FA proteins such as focal adhesion kinase (FAK), talin, and vinculin
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A neoteric antibacterial ceria-silver nanozyme for abiotic surfaces Biomaterials (IF 14.0) Pub Date : 2024-03-18 Abinaya Sindu Pugazhendhi, Craig J. Neal, Khoa Minh Ta, Marco Molinari, Udit Kumar, Fei Wei, Elayaraja Kolanthai, Andrew Ady, Christina Drake, Megan Hughes, Shibu Yooseph, Sudipta Seal, Melanie J. Coathup
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Plant mucus-derived microgels: Blood-triggered gelation and strong hemostatic adhesion Biomaterials (IF 14.0) Pub Date : 2024-03-16 Yu Huang, Weichao Hu, Kaige Xu, Ruijue Dan, Shali Tan, Zhenzhen Shu, Xin Li, Hangzong Liu, Chaoqiang Fan, Malcolm Xing, Shiming Yang
Arrest of bleeding usually applies clotting agents to trigger coagulation procedures or adhesives to interrupt blood flow through sealing the vessel; however, the efficiency is compromised. Here, we propose a concept of integration of hemostasis and adhesion via yam mucus's microgels. The mucus microgels exhibit attractive attributes of hydrogel with uniform size and shape. Their shear-thinning, self-healing
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ROS-responsive drug-releasing injectable microgels for ameliorating myocardial infarction Biomaterials (IF 14.0) Pub Date : 2024-03-16 Shuqin Wang, Yuejun Yao, Liang Song, Zihe Zhai, Shifen Li, Zhaolong Wang, Liyin Shen, Yang Zhu, Wenxing Liu, Changyou Gao
Despite of the recent advances in regulatory T cell (Treg) therapy, a limited number of available cells and specificity at the desired tissue site have severely compromised their efficacy. Herein, an injectable drug-releasing (MTK-TK-drug) microgel system in response to stimulation by reactive oxygen species (ROS) was constructed with a coaxial capillary microfluidic system and UV curing. The spherical
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“On/off”-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX Biomaterials (IF 14.0) Pub Date : 2024-03-14 Shuaijun Li, Caiting Meng, Qian Hao, Ruina Zhou, Luyao Dai, Yucheng Guo, Sitong Zhao, Xin Zhou, Chunju Lou, Ji Xu, Peng Xu, Jinfan Yang, Yifan Ding, Yanni Lv, Shengli Han, Shuai Li, Jing Li, Huafeng Kang, Zhengtao Xiao, Mingqian Tan, Xiaobin Ma, Hao Wu
Non-small cell lung cancer (NSCLC) brain metastases present a significant treatment challenge due to limited drug delivery efficiency and severe adverse reactions. In this study, we address these challenges by designing a “on/off” switchable crosslinked paclitaxel (PTX) nanocarrier, BPM-PD, with novel ultra-pH-sensitive linkages (pH 6.8 to 6.5). BPM-PD demonstrates a distinct “on/off” switchable release
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Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection Biomaterials (IF 14.0) Pub Date : 2024-03-14 Menglin Sun, Jiameng Wang, Xiaobo Huang, Ruiqiang Hang, Peide Han, Jiqiang Guo, Xiaohong Yao, Paul K. Chu, Xiangyu Zhang
The poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO nanorod arrays and -arginine (BaTiO/LA)
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MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes Biomaterials (IF 14.0) Pub Date : 2024-03-13 Yangyang Zhu, Pin Chen, Bochuan Hu, Suqin Zhong, Kai Yan, Yu Wu, Shanshan Li, Yinyin Yang, Zexin Xu, Yutong Lu, Ying Ouyang, Hui Bao, Weiguang Gu, Longping Wen, Yunjiao Zhang
Myeloid-derived suppressor cells (MDSCs) play a crucial role in the immune escape mechanisms that limit the efficacy of immunotherapeutic strategies. In the tumor microenvironment, NLRP3 inflammasome-driven Interleukin-1β (IL-1β) production serves to dampen antitumor immune responses, promoting tumor growth, progression, and immunosuppression. In this study, we revealed that gold nanoparticles (Au
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Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation Biomaterials (IF 14.0) Pub Date : 2024-03-11 Baoyi Li, Menghang Zu, Aodi Jiang, Yingui Cao, Jiaxue Wu, Mohammad-Ali Shahbazi, Xiaoxiao Shi, Rui L. Reis, Subhas C. Kundu, Bo Xiao
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Perfusable adipose decellularized extracellular matrix biological scaffold co-recellularized with adipose-derived stem cells and L6 promotes functional skeletal muscle regeneration following volumetric muscle loss Biomaterials (IF 14.0) Pub Date : 2024-03-11 Wei Liang, Meng Han, Guan Li, Wanwen Dang, Huiting Wu, Xiaoyu Meng, Yonghuan Zhen, Weibo Lin, Rigele Ao, Xiaoqing Hu, Yang An