Current vascular grafts, primarily Gore-Tex® and Dacron®, don't integrate with the host and have low patency in small-diameter vessels (<6 mm). Biomaterials that possess appropriate viscoelasticity, compliance, and high biocompatibility are essential for their application in small blood vessels. We have developed metal ion crosslinked poly(propanediol--(hydroxyphenyl methylene)amino-propanediol sebacate) (M-PAS), a biodegradable elastomer with a wide range of mechanical properties. We call these materials metallo-elastomers. An initial test on Zn-, Fe-, and Cu-PAS grafts reveals that Cu-PAS is the most suitable because of its excellent elastic recoil and well-balanced polymer degradation/tissue regeneration rate. Here we report host remodeling of Cu-PAS vascular grafts in rats over one year. 76 % of the grafts remain patent and >90 % of the synthetic polymer is degraded by 12 months. Extensive cell infiltration leads to a positive host remodeling. The remodeled grafts feature a fully endothelialized lumen. Circumferentially organized smooth muscle cells, elastin fibers, and widespread mature collagen give the neoarteries mechanical properties similar to native arteries. Proteomic analysis further reveals the presence of important vascular proteins in the neoarteries. Evidence suggests that Cu-PAS is a promising material for engineering small blood vessels.

中文翻译：

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颈动脉介入模型中金属弹性体移植物一年多的转化


目前的血管移植物，主要​​是 Gore-Tex® 和 Dacron®，无法与宿主融合，并且在小直径血管 (<6 mm) 中的通畅性较低。具有适当粘弹性、顺应性和高生物相容性的生物材料对于其在小血管中的应用至关重要。我们开发了金属离子交联聚（丙二醇-（羟苯基亚甲基）氨基丙二醇癸二酸酯）（M-PAS），这是一种具有广泛机械性能的可生物降解弹性体。我们将这些材料称为金属弹性体。对 Zn-、Fe- 和 Cu-PAS 接枝物的初步测试表明，Cu-PAS 是最合适的，因为它具有出色的弹性反冲力和均衡的聚合物降解/组织再生率。在此，我们报告了大鼠体内 Cu-PAS 血管移植物一年多的宿主重塑。 76% 的移植物保持专利状态，并且 >90% 的合成聚合物在 12 个月内降解。广泛的细胞浸润导致宿主的积极重塑。重塑的移植物具有完全内皮化的管腔。圆周组织的平滑肌细胞、弹性蛋白纤维和广泛的成熟胶原赋予新动脉与天然动脉相似的机械特性。蛋白质组学分析进一步揭示了新动脉中重要血管蛋白的存在。有证据表明，Cu-PAS 是一种很有前景的小血管工程材料。