Posterior capsule opacification (PCO) is a predominant postoperative complication, often leading to visual impairment due to the aberrant proliferation and adhesion of lens epithelial cells (LECs) and protein precipitates subsequent to intraocular lens (IOL) implantation. To address this clinical issue, a foldable and antifouling sharp-edged IOL implant based on naturally-derived cellulose hydrogel is synthesized. The mechanical strength and transparency of the hydrogel is enhanced via repeated freeze-thaw (FT) cycles. The incorporated zwitterionic modifications can remarkably prevent the incidence of PCO by exhibiting proteins repulsion and cell anti-adhesion properties. The graft of dopamine onto both the haptic and the periphery of the posterior surface ensures the adhesion of the hydrogel to the posterior capsule and impedes the migration of LECs without compromising transparency. In study, the zwitterionic modified foldable hydrogel exhibits uveal and capsular biocompatibility synchronously with no signs of inflammatory response and prevent PCO formation, better than that of commercialized and PEG-modified IOL. With foldability, endurability, antifouling effect, and adhesive to posterior capsule, the reported hydrogel featuring heterogeneous surface design displays great potential to eradicate PCO and attain post-operative efficacy after cataract surgery.

中文翻译：

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两性离子改性和冻融增强可折叠水凝胶作为人工晶状体用于预防后囊混浊


后囊混浊（PCO）是主要的术后并发症，通常由于人工晶状体（IOL）植入后晶状体上皮细胞（LEC）和蛋白质沉淀的异常增殖和粘附而导致视力障碍。为了解决这个临床问题，我们合成了一种基于天然纤维素水凝胶的可折叠、防污、锋利边缘的人工晶状体植入物。通过反复冻融（FT）循环，水凝胶的机械强度和透明度得到增强。掺入的两性离子修饰可以通过表现出蛋白质排斥和细胞抗粘附特性来显着预防 PCO 的发生。将多巴胺移植到触觉和后表面周边确保了水凝胶与后囊的粘附，并在不影响透明度的情况下阻止 LEC 的迁移。在研究中，两性离子改性可折叠水凝胶同时表现出葡萄膜和囊膜生物相容性，没有炎症反应迹象，并能防止 PCO 形成，优于商业化和 PEG 修饰的 IOL。所报道的具有异质表面设计的水凝胶具有可折叠性、耐用性、防污作用和对后囊的粘附性，在白内障手术后具有根除PCO并获得术后疗效的巨大潜力。