Herein, we describe the 3′-sialyllactose-polyethyleneimine-chlorine e6 conjugate (3PC), meticulously engineered to effectively target Helicobacter bacteria () within the gastric environment. The composition of 3PC comprises polyethyleneimine, a cationic polymer, 3′-sialyllactose, which exhibits a specific binding affinity for surface proteins, and a photosensitizer capable of generating oxygen radicals in response to specific wavelengths. The distinctive feature of 3PC lies in its capacity to enhance interaction with the anionic mucus layer facilitated by electrostatic forces. This interaction results in prolonged residence within the intestinal environment. The extended vacation in the intestinal milieu overcomes inherent limitations that have historically impeded conventional antibiotics from efficiently reaching and targeting . 3PC can be harnessed as a potent tool for antibacterial photodynamic therapy, and its versatility extends to addressing the challenges posed by various antibiotic-resistant strains. The exceptional efficacy of 3PC in enhancing intestinal residence time and eradicating has been robustly substantiated in animal models, particularly in mice. In summary, 3PC is a formidable agent capable of eradicating , irrespective of its antibiotic resistance status, by efficiently penetrating and selectively targeting the mucus layer within the gastric environment.

中文翻译：

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利用基于粘蛋白粘附聚合物的疗法克服幽门螺杆菌基因突变引起的抗生素耐药性

在此，我们描述了 3'-唾液酸乳糖-聚乙烯亚胺-氯 e6 缀合物 (3PC)，该缀合物经过精心设计，可有效靶向胃环境中的螺杆菌 ()。 3PC的组合物包含聚乙烯亚胺、阳离子聚合物、对表面蛋白质具有特异性结合亲和力的3'-唾液酸乳糖以及能够响应特定波长产生氧自由基的光敏剂。 3PC 的显着特征在于其能够通过静电力增强与阴离子粘液层的相互作用。这种相互作用导致在肠道环境中的停留时间延长。肠道环境的延长假期克服了历史上阻碍传统抗生素有效到达和靶向的固有限制。 3PC 可以作为抗菌光动力疗法的有效工具，其多功能性还可以解决各种抗生素耐药菌株带来的挑战。 3PC 在延长肠道停留时间和根除肠道菌群方面的卓越功效已在动物模型（尤其是小鼠）中得到充分证实。总之，3PC 是一种强大的药剂，能够通过有效渗透并选择性地靶向胃环境内的粘液层来根除抗生素，无论其抗生素耐药性状况如何。