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Integrated analyses reveal CST7 and DUSP5 regulate Th2 cells differentiation to promote chronic HBV infection Genes. Immun. (IF 5.0) Pub Date : 2024-09-05 Gang Ning, Xianxiang Liao, Hongye Jiang
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Integrated machine learning survival framework to decipher diverse cell death patterns for predicting prognosis in lung adenocarcinoma Genes. Immun. (IF 5.0) Pub Date : 2024-08-31 Fangchao Zhao, Xu Zhang, Yanhua Tian, Haiyong Zhu, Shujun Li
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Innate immune dynamics in the context of multisite EGFR mutations in lung adenocarcinoma Genes. Immun. (IF 5.0) Pub Date : 2024-08-06 Yuan Peng, Chuan Zeng, Rongxin Liao, Lu Shen, Yan Zhou, Zhenzhou Yang
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Apolipoprotein E deficiency leads to the polarization of splenic macrophages towards M1 phenotype by increasing iron content Genes. Immun. (IF 5.0) Pub Date : 2024-08-05 Meng-Qi Shen, Qian Guo, Wei Li, Zhong-Ming Qian
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Identification of the ferroptosis‐related gene signature and the associated regulation axis in lung cancer and rheumatoid arthritis Genes. Immun. (IF 5.0) Pub Date : 2024-07-29 Bo Cai, Yibin Huang, Dandan Liu, Yizheng You, Nuoshi Chen, Ligang Jie, Hongyan Du
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Machine-learning and scRNA-Seq-based diagnostic and prognostic models illustrating survival and therapy response of lung adenocarcinoma Genes. Immun. (IF 5.0) Pub Date : 2024-07-29 Qingyu Cheng, Weidong Zhao, Xiaoyuan Song, Tengchuan Jin
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The ability of microRNAs to regulate the immune response in ischemia/reperfusion inflammatory pathways Genes. Immun. (IF 5.0) Pub Date : 2024-06-22 Peter Artimovič, Ivana Špaková, Ema Macejková, Timea Pribulová, Miroslava Rabajdová, Mária Mareková, Martina Zavacká
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Sphingomyelin-derived epacadostat nanovesicle enhances IDO1 inhibition for improved melanoma combination immunotherapy Genes. Immun. (IF 5.0) Pub Date : 2024-06-11 Zhiren Wang, Wenpan Li, Jianqin Lu
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Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry Genes. Immun. (IF 5.0) Pub Date : 2024-06-06 Eric Engelbrecht, Oscar L. Rodriguez, Kaitlyn Shields, Steven Schultze, David Tieri, Uddalok Jana, Gur Yaari, William D. Lees, Melissa L. Smith, Corey T. Watson
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Machine learning-derived immunosenescence index for predicting outcome and drug sensitivity in patients with skin cutaneous melanoma Genes. Immun. (IF 5.0) Pub Date : 2024-05-29 Linyu Zhu, Lvya Zhang, Junhua Qi, Zhiyu Ye, Gang Nie, Shaolong Leng
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Osteogenesis imperfecta type 10 and the cellular scaffolds underlying common immunological diseases Genes. Immun. (IF 5.0) Pub Date : 2024-05-29 Alan Herbert
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TIMP-1 is an activator of MHC-I expression in myeloid dendritic cells with implications for tumor immunogenicity Genes. Immun. (IF 5.0) Pub Date : 2024-05-22 Miriam Langguth, Eleftheria Maranou, Saara A. Koskela, Oskar Elenius, Roosa E. Kallionpää, Eva-Maria Birkman, Otto I. Pulkkinen, Maria Sundvall, Marko Salmi, Carlos R. Figueiredo
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MDSC expansion during HIV infection: regulators, ART and immune reconstitution Genes. Immun. (IF 5.0) Pub Date : 2024-04-11 Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani
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Comparative single-cell transcriptomic profile of hybrid immunity induced by adenovirus vector-based COVID-19 vaccines Genes. Immun. (IF 5.0) Pub Date : 2024-04-03 Melissa García-Vega, Hui Wan, Mónica Reséndiz-Sandoval, Diana Hinojosa-Trujillo, Olivia Valenzuela, Verónica Mata-Haro, Freddy Dehesa-Canseco, Mario Solís-Hernández, Harold Marcotte, Qiang Pan-Hammarström, Jesús Hernández
In this study, antibody response and a single-cell RNA-seq analysis were conducted on peripheral blood mononuclear cells from five different groups: naïve subjects vaccinated with AZD1222 (AZ) or Ad5-nCoV (Cso), individuals previously infected and later vaccinated (hybrid) with AZD1222 (AZ-hb) or Ad5-nCoV (Cso-hb), and those who were infected and had recovered from COVID-19 (Inf). The results showed
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Neu5Gc regulates decidual macrophages leading to abnormal embryo implantation Genes. Immun. (IF 5.0) Pub Date : 2024-03-18 Wu Yue, Zhou Huiling, Liu Yuxin, Wang Ling, Gao Feng, Liu Qicai
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Chemoimmunotherapy combinations: translating basic knowledge into clinical successes Genes. Immun. (IF 5.0) Pub Date : 2024-03-13 Lionel Apetoh
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Intratumoral NK cell delivery combined with neutralization of the NKG2A pathway as treatment for solid cancer Genes. Immun. (IF 5.0) Pub Date : 2024-03-09 Ignacio Melero, Carmen Molina, Cristina Eguizabal, Maite Alvarez
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Getting under the skin: resident memory CD8+ T cells have a second residence in the draining lymph node Genes. Immun. (IF 5.0) Pub Date : 2024-03-08 Teresa Neuwirth, Azuah L. Gonzalez, Emilie Fisher-Gupta, Georg Stary
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Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease Genes. Immun. (IF 5.0) Pub Date : 2024-02-23 Marisa Flook, Elena Rojano, Alvaro Gallego-Martinez, Alba Escalera-Balsera, Patricia Perez-Carpena, M. del Carmen Moleon, Rocio Gonzalez-Aguado, Victoria Rivero de Jesus, Emilio Domínguez-Durán, Lidia Frejo, Juan A. G. Ranea, Jose Antonio Lopez-Escamez
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Navigating the thymic landscape through development: from cellular atlas to tissue cartography Genes. Immun. (IF 5.0) Pub Date : 2024-02-10 Dörte Symmank, Felix Clemens Richter, André F. Rendeiro
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An immunogenomic exome landscape of triple positive primary antiphospholipid patients Genes. Immun. (IF 5.0) Pub Date : 2024-01-24 A. Guffroy, L. Jacquel, Y. Seeleuthner, N. Paul, V. Poindron, F. Maurier, V. Delannoy, A. C. Voegeli, P. Zhang, B. Nespola, A. Molitor, M. J. Apithy, P. Soulas-Sprauel, T. Martin, R. E. Voll, S. Bahram, V. Gies, J. L. Casanova, A. Cobat, B. Boisson, R. Carapito, A. S. Korganow
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BCL2 inhibition stimulates dendritic cell function for improved anticancer immunotherapy Genes. Immun. (IF 5.0) Pub Date : 2024-01-24 Peng Liu, Liwei Zhao, Guido Kroemer, Oliver Kepp
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Same name, different game?—How ontogeny shapes classical monocyte phenotypes Genes. Immun. (IF 5.0) Pub Date : 2024-01-20 Lisabeth Pimenov, Azuah Lucrecia Gonzalez, Amanda C. Doran, Sylvia Knapp
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Do inhibitory receptors need to be proximal to stimulatory receptors to function? Genes. Immun. (IF 5.0) Pub Date : 2024-01-12 Jonathan D. Worboys, Daniel M. Davis
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Preclinical models of breast cancer: B6BC, a transplantable hormone receptor-positive C57BL/6 mouse cell line. Genes. Immun. (IF 5.0) Pub Date : 2024-01-13 Maria Perez-Lanzon,Maria Chiara Maiuri,Carlos Lopez-Otin,Guido Kroemer
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Environmental variation and genetic diversity contribute to population differences in immune responses to SARS-CoV-2 and COVID-19 risk Genes. Immun. (IF 5.0) Pub Date : 2023-12-23 Maxime Rotival, Lluis Quintana-Murci
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Uncovering intestinal macrophages through the integration of single-cell and spatial transcriptomics Genes. Immun. (IF 5.0) Pub Date : 2023-12-23 Alba Garrido-Trigo, Marisol Veny, Azucena Salas
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The genomics revolution comes to the immunopeptidome Genes. Immun. (IF 5.0) Pub Date : 2023-12-22 Peter M. Bruno
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Deciphering the host genetic factors conferring susceptibility to severe COVID-19 using exome sequencing Genes. Immun. (IF 5.0) Pub Date : 2023-12-20 Kubra Uslu, Firat Ozcelik, Gokmen Zararsiz, Vahap Eldem, Ahu Cephe, Izem Olcay Sahin, Recep Civan Yuksel, Hilal Sipahioglu, Zuhal Ozer Simsek, Osman Baspinar, Hilal Akalin, Yasin Simsek, Kursat Gundogan, Nuri Tutar, Aynur Karayol Akin, Yusuf Ozkul, Orhan Yildiz, Munis Dundar
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Boosting SARS-CoV-2 immunity in immunocompromised individuals. Genes. Immun. (IF 5.0) Pub Date : 2023-12-19 Thomas R Müller,Marcus Buggert
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AHR and tryptophan metabolism: a collaborative dynamics of immune regulation Genes. Immun. (IF 5.0) Pub Date : 2023-12-16 Jingjing Zhu, Benoit J. Van den Eynde
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Orchestrating an immune response to cancer with cellular reprogramming Genes. Immun. (IF 5.0) Pub Date : 2023-12-15 Olga Zimmermannova, Alexandra Gabriela Ferreira, Carlos-Filipe Pereira
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From patient tissue correlates to molecular mechanisms of cancer immune evasion: the emerging role of CD58 and PD-L1 co-regulation via CMTM6 Genes. Immun. (IF 5.0) Pub Date : 2023-12-11 Johannes C. Melms, Patricia Ho, Meri Rogava, Benjamin Izar
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Targeting CTLA-4: a possible solution for microsatellite-stable colorectal cancer Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 François Ghiringhelli, Marion Thibaudin
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Serving up whatever you wish: CRISPR-base editing generates novel cancer-restricted antigens for immunotherapy Genes. Immun. (IF 5.0) Pub Date : 2023-12-11 Ute E. Burkhardt, Edward F. Fritsch
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Mapping the landscape of T cell-recognized neoantigens in cancer patients Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 Wouter Scheper
Immunotherapies for cancer that seek to leverage the anti-tumor reactivity of T cells, such as immune checkpoint inhibition, have yielded remarkable clinical effects in a proportion of cancer patients. Evidence from work performed over the last 5–10 years suggests that the clinical efficacy of these therapies in many cases depends on the reactivity of patient T cells to so-called neoantigens—short
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To whom B cells toll extrafollicular responses Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 Jonathan H. Lam, Nicole Baumgarth
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Interleukin-3 gets a fresh start in the brain Genes. Immun. (IF 5.0) Pub Date : 2023-12-08 Abi G. Yates, Annie Khamhoung, Cameron S. McAlpine
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RNA modifications-a regulatory dimension yet to be deciphered in immunity. Genes. Immun. (IF 5.0) Pub Date : 2023-12-01 Cuong Thi Pham,Laurie Rangan,Susan Schlenner
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Genetic variants of interferon-response factor 5 are associated with the incidence of chronic kidney disease: the D.E.S.I.R. study Genes. Immun. (IF 5.0) Pub Date : 2023-11-17 Frédéric Fumeron, Gilberto Velho, Fawaz Alzaid, Ray El Boustany, Claire Vandiedonck, Amélie Bonnefond, Philippe Froguel, Louis Potier, Michel Marre, Beverley Balkau, Ronan Roussel, Nicolas Venteclef
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Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2) Genes. Immun. (IF 5.0) Pub Date : 2023-11-04 Aroosha Raja, Jonas J. W. Kuiper
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Circulating biomarkers at diagnosis correlate with distant metastases of early luminal-like breast cancer Genes. Immun. (IF 5.0) Pub Date : 2023-09-27 Yentl Lambrechts, Abhishek D. Garg, Giuseppe Floris, Kevin Punie, Patrick Neven, Ines Nevelsteen, Jannes Govaerts, François Richard, Annouschka Laenen, Christine Desmedt, Hans Wildiers, Sigrid Hatse
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“IL-2 immunotherapy for targeting regulatory T cells in autoimmunity” Genes. Immun. (IF 5.0) Pub Date : 2023-09-23 Valentina Lykhopiy, Vanshika Malviya, Stephanie Humblet-Baron, Susan M. Schlenner
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Disentangling the complexity of psoriasis in the post-genome-wide association era Genes. Immun. (IF 5.0) Pub Date : 2023-09-16 Charalabos Antonatos, Katerina Grafanaki, Sophia Georgiou, Evangelos Evangelou, Yiannis Vasilopoulos
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Reverse translation: the key to increasing the clinical success of immunotherapy? Genes. Immun. (IF 5.0) Pub Date : 2023-09-11 Isaure Vanmeerbeek, Stefan Naulaerts, Abhishek D. Garg
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Hypertonic saline induces inflammation in human macrophages through the NLRP1 inflammasome Genes. Immun. (IF 5.0) Pub Date : 2023-08-12 Francesca Sposito, Sarah Northey, Amandine Charras, Paul S. McNamara, Christian M. Hedrich
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Research progress on the application of single-cell sequencing in autoimmune diseases Genes. Immun. (IF 5.0) Pub Date : 2023-08-07 Xueli Yang, Xianliang Hou, Junning Zhang, Zhenyu Liu, Guangyu Wang
Autoimmune diseases (AIDs) are caused by immune tolerance deficiency or abnormal immune regulation, leading to damage to host organs. The complicated pathogenesis and varied clinical symptoms of AIDs pose great challenges in diagnosing and monitoring this disease. Regrettably, the etiological factors and pathogenesis of AIDs are still not completely understood. It is noteworthy that the development
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Clinical, immunological and molecular findings of 8 patients with typical and atypical severe combined immunodeficiency: identification of 7 novel mutations by whole exome sequencing Genes. Immun. (IF 5.0) Pub Date : 2023-07-29 Zahra Alizadeh, Mohammad Reza Fazlollahi, Marzieh Mazinani, Mohsen Badalzadeh, Hanieh Heydarlou, Raphael Carapito, Anne Molitor, Andrés Caballero Garcia de Oteyza, Michele Proietti, Maryam Soleimani Bavani, Mansoureh Shariat, Morteza Fallahpour, Masoud Movahedi, Leila Moradi, Bodo Grimbacher, Seiamak Bahram, Zahra Pourpak
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Transmission disequilibrium analysis of whole genome data in childhood-onset systemic lupus erythematosus Genes. Immun. (IF 5.0) Pub Date : 2023-07-24 Kathleen M. Vazzana, Anthony M. Musolf, Joan E. Bailey-Wilson, Linda T. Hiraki, Earl D. Silverman, Christiaan Scott, Clifton L. Dalgard, Sarfaraz Hasni, Zuoming Deng, Mariana J. Kaplan, Laura B. Lewandowski
Childhood-onset systemic lupus erythematosus (cSLE) patients are unique, with hallmarks of Mendelian disorders (early-onset and severe disease) and thus are an ideal population for genetic investigation of SLE. In this study, we use the transmission disequilibrium test (TDT), a family-based genetic association analysis that employs robust methodology, to analyze whole genome sequencing data. We aim
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The dynamic interface of genetics and immunity: toward future horizons in health & disease Genes. Immun. (IF 5.0) Pub Date : 2023-07-18 Abhishek D. Garg
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Exploiting big data survival information to unify risk-stratification related, adaptive immune receptor parameters for multiple myeloma Genes. Immun. (IF 5.0) Pub Date : 2023-07-13 Hope J. Wolmarans, Vayda R. Barker, Andrea Chobrutskiy, Boris I. Chobrutskiy, Taha I. Huda, George Blanck
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Systems-level profiling of early peripheral host-response landscape variations across COVID-19 severity states in an Indian cohort Genes. Immun. (IF 5.0) Pub Date : 2023-07-12 Ushashi Banerjee, Sneha Chunchanur, Ambica R, Kithiganahalli Narayanaswamy Balaji, Amit Singh, Dipshikha Chakravortty, Nagasuma Chandra
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Integrated analyses reveal the prognostic, immunological features and mechanisms of cuproptosis critical mediator gene FDX1 in KIRC Genes. Immun. (IF 5.0) Pub Date : 2023-07-10 Yi Wang, Xinyu Zhang, Guihua Chen, Qianwei Xing, Bingye Zhu, Xiang Wang
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Potential diagnostic biomarkers: 6 cuproptosis- and ferroptosis-related genes linking immune infiltration in acute myocardial infarction Genes. Immun. (IF 5.0) Pub Date : 2023-07-08 Mengdan Miao, Shanhu Cao, Yifei Tian, Da Liu, Lixia Chen, Qiaoying Chai, Mei Wei, Shaoguang Sun, Le Wang, Shuanli Xin, Gang Liu, Mingqi Zheng
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αCGRP deficiency aggravates pulmonary fibrosis by activating the PPARγ signaling pathway Genes. Immun. (IF 5.0) Pub Date : 2023-05-25 Xiaoting Lv, Qingquan Chen, Zewei Zhang, Kaili Du, Yaping Huang, Xingzhe Li, Yiming Zeng
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IgE-binding monocytes upregulate the coagulation cascade in allergic horses Genes. Immun. (IF 5.0) Pub Date : 2023-05-16 Elisabeth M. Simonin, Bettina Wagner
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Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease Genes. Immun. (IF 5.0) Pub Date : 2023-05-08 Aliya Rehati, Buzukela Abuduaini, Zhao Liang, Dong Chen, Fangping He
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Modulation of immune checkpoint regulators in interferon γ induced urothelial carcinoma and activated T-lymphocyte cells by cytostatics Genes. Immun. (IF 5.0) Pub Date : 2023-05-03 Jörg Hänze, Johannes Schulte-Herbrüggen, Rainer Hofmann, Axel Hegele
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Genetic epidemiology of resistance to M. tuberculosis Infection: importance of study design and recent findings Genes. Immun. (IF 5.0) Pub Date : 2023-04-22 Catherine M. Stein
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Long non-coding RNA maternally expressed gene 3, miR-125a-5p, CXCL13, and NF-kB in patients with immune thrombocytopenia Genes. Immun. (IF 5.0) Pub Date : 2023-04-12 Mervat Naguib, Shereen El Sawy, Laila Rashed, Maha AlHelf, Marwa Abdelgwad