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Ultra-sensitive and rapid detection of Salmonella enterica and Staphylococcus aureus to single-cell level by aptamer-functionalized carbon nanotube field-effect transistor biosensors Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Xiaoxuan Feng, Pengzhen Li, Tingxian Li, Xiaoling Cao, Daohe Liu, Mengmeng Xiao, Li Wang
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Electrospun EU/HPMC nanofibers decorated by ZIF-8 nanoparticle as the advanced electrochemical biosensor modifier for sensitive and selective detection of c-MET cancer biomarker in human plasma sample Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-24 Fatemeh Maleki, Habib Razmi, Mohammad-Reza Rashidi, Mehdi Yousefi, Soghra Ramezani, Marjan Ghorbani
This research presents a selective and sensitive electrochemical biosensor for the detection of the mesenchymal–epithelial transition factor (c-MET). The biosensing is based on a modification of the SPCE (screen-printed carbon electrode) with the electrospun nanofiber containing eudragit (EU), hydroxypropyl methylcellulose (HPMC), and Zeolite imidazolate frameworks (ZIF-8) nanoparticles. EU/HPMC/ZIF-8
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A cell-free biosensor for multiplexed and sensitive detection of biological warfare agents Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-23 Yu Jin Park, Sunjoo Choi, Kyung Won Lee, So-Yoon Park, Dong-Yeon Song, Tae Hyeon Yoo, Dong-Myung Kim
The rapid and precise detection of pathogenic agents is critical for public health and societal stability. The detection of biological warfare agents (BWAs) is especially vital within military and counter-terrorism contexts, essential in defending against biological threats. Traditional methods, such as polymerase chain reaction (PCR), are limited by their need for specific settings, impacting their
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An instrument-free, integrated micro-platform for rapid and multiplexed detection of dairy adulteration in resource-limited environments Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-23 Nan Wang, Xiaoyun Sun, Juan Zhang, Ying Chen, Jiukai Zhang, Fengchun Huang, Ailiang Chen
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MOF-derived sandwich-structured dual Z-Scheme Co9S8@ZnIn2S4/CdSe hollow nanocages heterojunction: Target-induced ultrasensitive photoelectrochemical sensing of chlorpyrifos Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Ben-Fang Xu, Jin Zhang, Aisyah Protonia Tanjung, Fan Xu, Ai-Jun Wang, Li-Ping Mei, Pei Song, Jiu-Ju Feng
Exploring efficient photoactive material presents an intriguing opportunity to enhance the analytical performance of photoelectrochemical (PEC) sensor in the environmental analysis. In this work, a sandwich-structured multi-interface CoS@ZnInS/CdSe QDs dual Z-Scheme heterojunction, derived from metal-organic framework (MOF), was synthesized as a sensing platform for chlorpyrifos detection, by integrating
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Fluorescent metal nanoclusters: From luminescence mechanism to applications in enzyme activity assays Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Tong Wang, Hong-Sheng Tan, Ai-Jun Wang, Shan-Shan Li, Jiu-Ju Feng
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Culture-free detection of β-lactamase-Producing bacteria in urinary tract infections using a paper sensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-22 Guangming Liu, Wenshuai Li, Siya Li, Jia Xu, Xinsheng Wang, Hua Xu, Dingbin Liu, Hongmei Gao
Developing simple, inexpensive, fast, sensitive, and specific probes for antibiotic-resistant bacteria is crucial for the management of urinary tract infections (UTIs). We here propose a paper-based sensor for the rapid detection of -lactamase-producing bacteria in the urine samples of UTI patients. By conjugating a strongly electronegative group –N(CH) with the core structures of cephalosporin and
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NIR-driven multifunctional PEC biosensor based on aptamer-modified PDA/MnO2 photoelectrode for bacterial detection and inactivation Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-20 Anni Cui, Lihua Dong, Yiting Hou, Xin Mu, Yu Sun, Huan Wang, Xiahua Zhong, Guiye Shan
Sensitive detection and effective inactivation of bacteria are essential in preventing foodborne bacterial infection that poses a significant threat to human health. Herein, a near-infrared (NIR)-driven multifunctional photoelectrochemical (PEC) biosensor was constructed for detection and inactivation of . Based on the covalent bonding between amine and carboxyl groups, carboxyl-functionalized SA31
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A dual-channel electrochemical biosensor enables concurrent detection of pathogens and antibiotic resistance Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-20 Dharanivasan Gunasekaran, Irina Rostovsky, David Taussig, Talya Bar-Am, Yariv Wine, Neta Sal-Man, Sefi Vernick
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Polymeric optical fiber biosensor with PAMAM dendrimer-based surface modification and PlGF detection for pre-eclampsia diagnosis Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-18 Ratan Kumar Chaudhary, Narayanan Madaboosi, Jitendra Satija, Balaji Nandagopal, Ramprasad Srinivasan, V.V.R. Sai
Pre-eclampsia (PE) is a life-threatening complication that occurs during pregnancy, affecting a large number of pregnant women and newborns worldwide. Rapid, on-site and affordable screening of PE at an early stage is necessary to ensure timely treatment and minimize both maternal and neonatal morbidity and mortality rates. Placental growth factor (PlGF) is an angiogenic blood biomarker used for PE
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Editorial note: Low temperature synthesis of carbon dots in microfluidic chip and their application for sensing cefquinome residues in milk [Biosens. Bioelectron. 228 (2023) 115187] Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-18 Guangming Li, Chen Liu, Xingcai Zhang, Peng Zhai, Xinyi Lai, Wenxiao Jiang
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Rational design of nanozyme with integrated sample pretreatment for colorimetric biosensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Jia Wu, Ling Liang, Shuishi Li, Yuan Qin, Shulin Zhao, Fanggui Ye
Nanozymes have been widely used in the field of biosensing owing to their high stability, low cost, adjustable catalytic activity, and convenient modification. However, achieving high selectivity and sensitivity simultaneously in nanozyme-based colorimetric sensing remains a major challenge. Nanozymes are nanomaterials with enzyme-simulating activity that are often used as solid-phase adsorbents for
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Vortexing-generated high throughput single-cell droplets for facile analysis of multiplexed microRNA dynamic secretion Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Fengjiao Zhu, Yangyang Long, Weiwei Shi, Bin Li, Yahui Ji, Xue Bai, Xianming Liu, Dongyuan Qi, Bo Sun, Fuyin Zhang, Tingjiao Liu, Bingcheng Lin, Yao Lu
Discriminating secretory phenotypes provides a direct, intact, and dynamic way to evaluate the heterogeneity in cell states and activation, which is significant for dissecting non-genetic heterogeneity for human health studies and disease diagnostics. In particular, secreted microRNAs, soluble signaling molecules released by various cells, are increasingly recognized as a critical mediator for cell-cell
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Recent advances in implantable sensors and electronics using printable materials for advanced healthcare Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Seunghyeb Ban, Haran Lee, Jiehao Chen, Hee-Seok Kim, Yuhang Hu, Seong J. Cho, Woon-Hong Yeo
This review article focuses on the recent printing technological progress in healthcare, underscoring the significant potential of implantable devices across diverse applications. Printing technologies have widespread use in developing health monitoring devices, diagnostic systems, and surgical devices. Recent years have witnessed remarkable progress in fabricating low-profile implantable devices,
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Paper-based loop-mediated isothermal amplification and CRISPR integrated platform for on-site nucleic acid testing of pathogens Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-17 Anindita Sen, Manaswini Masetty, Sasanka Weerakoon, Calum Morris, Jagjit S. Yadav, Senu Apewokin, Jennifer Trannguyen, Murray Broom, Aashish Priye
We report the development and initial validation of a paper-based nucleic acid testing platform that integrates Loop-mediated isothermal amplification (LAMP) with clustered regularly interspaced short palindromic repeats (CRISPR) technology, referred to as PLACID (Paper-based LAMP-CRISPR Integrated Diagnostics). LAMP eliminates the need for thermal cycling, resulting in simplified instrumentation,
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Combining deep learning and droplet microfluidics for rapid and label-free antimicrobial susceptibility testing of colistin Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Justine Riti, Guillaume Sutra, Thierry Naas, Hervé Volland, Stéphanie Simon, Karla Perez-Toralla
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A self-powered and supercapacitive microneedle continuous glucose monitoring system with a wide range of glucose detection capabilities Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Hye-Jun Kil, Jang Hyeon Kim, Kanghae Lee, Tae-Uk Kang, Ju-Hyun Yoo, Yong-ho Lee, Jin-Woo Park
Continuous detection of sudden changes in blood glucose is essential for individuals with diabetes who have difficulty in maintaining optimal control of their blood glucose levels. Hypoglycemic shock or a hyperglycemic crisis are likely to occurs in patients with diabetes and poses a significant threat to their lives. Currently, commercial continuous glucose monitoring (CGM) has limits in the glucose
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Highly sensitive humidity sensor based on composite film of partially reduced graphene oxide and bacterial cellulose Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Jingyi Song, Mingshuai Fan, Rui Zhang, Meijie Qu, Ping Tang, Hai Wang, Yuezhen Bin
Breathing is an important physiological activity of human body, which not only reflects the state of human movement, but also is one of the important health indicators. Breathing can change the concentration of water molecules, so monitoring humidity has gradually become a hot topic in modern research. In this study, a humidity sensing composite film with high sensitivity and short response time was
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Wearable smart contact lenses: A critical comparison of three physiological signals outputs for health monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Fei Han, Juju Li, Pingping Xiao, Yanshen Yang, Hao Liu, Zhao Wei, Yuan He, Feng Xu
Smart contact lenses (SCLs) have been considered as novel wearable devices for out-of-hospital and self-monitoring applications. They are capable of non-invasively and continuously monitoring physiological signals in the eyes, including vital biophysical (, intraocular of pressure, temperature, and electrophysiological signal) and biochemical signals (, pH, glucose, protein, nitrite, lactic acid, and
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Adaptively resettable microfluidic patch for sweat rate and electrolytes detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Mengyuan Liu, Siyuan Liu, Tong Zhang, Dengfeng Zhou, Lianhui Li, Qiang Gao, Yujie Liu, Changlei Ge, Yongfeng Wang, Mingxu Wang, Feng Wen, Zuoping Xiong, Zhen Zhou, Shuqi Wang, Ting Zhang
Skin-interfaced microfluidic patch has become a reliable device for sweat collection and analysis. However, the intractable problems of emptying the microchannel for reuse, and the channel's volumetric capacity limited by the size of the patch, directly hinder the practical application of sweat sensors. Herein, we report an adaptively resettable microfluidic sweat patch (Art-Sweat patch) capable of
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A rapid and sensitive one-pot platform integrating fluorogenic RNA aptamers and CRISPR-Cas13a for visual detection of monkeypox virus Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-16 Xiao Wang, Xiaobao Deng, Yidun Zhang, Weiyi Dong, Qiao Rao, Qingmei Huang, Fei Tang, Rong Shen, Hongzhi Xu, Zhen Jin, Youzhi Tang, Dan Du
The recent global upsurge in Monkeypox virus (MPXV) outbreaks underscores the critical need for rapid and precise diagnostic solutions, particularly in resource-constrained settings. The gold standard diagnostic method, qRT-PCR, is hindered by its time-consuming nature, requirement for nucleic acid purification, expensive equipment, and the need for highly trained personnel. Traditional CRISPR/Cas
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Target proteins-regulated DNA nanomachine-electroactive substance complexes enable separation-free electrochemical detection of clinical exosome Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-14 Xianghu Zeng, Chengyong Wu, Ying Xiong, Zixuan Zhan, Congcong Shen, Feng Lin, Junlong Zhang, Piaopiao Chen
Simple and reliable profiling of tumor-derived exosomes (TDEs) holds significant promise for the early detection of cancer. Nonetheless, this remains challenging owing to the substantial heterogeneity and low concentration of TDEs. Herein, we devised an accurate and highly sensitive electrochemical sensing strategy for TDEs simultaneously targeting exosomal mucin 1 (MUC1) and programmed cell death
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Functionalized gold nanoparticle enhanced nanorod hyperbolic metamaterial biosensor for highly sensitive detection of carcinoembryonic antigen Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-12 Huimin Wang, Jintao Cai, Tao Wang, Ruoqin Yan, Ming Shen, Jinyan Zhang, Xinzhao Yue, Lu Wang, Xuyang Yuan, Enze Lv, Jinwei Zeng, Xuewen Shu, Jian Wang
Hyperbolic metamaterial (HMM) biosensors based on metals have superior performance in comparison with conventional plasmonic biosensors in the detection of low concentrations of molecules. In this study, a nanorod HMM (NHMM) biosensor based on refractive index changes for carcinoembryonic antigen (CEA) detection is developed using secondary antibody modified gold nanoparticle (AuNP-Ab) nanocomposites
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Rapid and multi-target genotyping of Helicobacter pylori with digital microfluidics Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-11 Jinsong Liu, Rongxin Fu, Shuailong Zhang, Jialu Hou, Hanbin Ma, Siyi Hu, Hang Li, Yanli Zhang, Weian Wang, Bokang Qiao, Baisheng Zang, Xun Min, Feng Zhang, Jie Du, Shengkai Yan
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Controllable detection threshold achieved through the toehold switch system in a mercury ion whole-cell biosensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-09 Qinglong Zhang, Zixiang Wei, Xiaoqiang Jia
Due to the toxicity of mercury and its harmful effects on human health, it is essential to establish a low-cost, highly sensitive and highly specific monitoring method with a wide detection range, ideally with a simple visual readout. In this study, a whole-cell biosensor with adjustable detection limits was developed for the detection of mercury ions in water samples, allowing controllable threshold
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An integrated wearable differential microneedle array for continuous glucose monitoring in interstitial fluids Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-09 Yong Yang, Can Sheng, Fang Dong, Sheng Liu
Monitoring biomarkers in human interstitial fluids (ISF) using microneedle sensors has been extensively studied. However, most of the previous studies were limited to simple in vitro demonstrations and lacked system integration and analytical performance. Here we report a miniaturized, high-precision, fully integrated wearable electrochemical microneedle sensing device that works with a customized
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An enzyme-free sensing platform for miRNA detection and in situ imaging in clinical samples based on DNAzyme cleavage-triggered catalytic hairpin assembly Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-09 Hechen Wang, Minzhe Shen, Xudan Shen, Jiatong Liu, Wenwen Huang, Xianfeng Jiang, Hui Liu, Su Zeng, Kewang Nan, Sheng Cai
MicroRNA (miRNA) is demonstrated to be associated with the occurrence and development of various diseases including cancer. Currently, most miRNA detection methods are confined to detection and cannot obtain information on the temporal and spatial expression of miRNA in relevant tissues and cells. In this work, we established a novel enzyme-free method that can be applied to both detection and imaging
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Graphene derivative-based ink advances inkjet printing technology for fabrication of electrochemical sensors and biosensors Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Martin-Alex Nalepa, David Panáček, Ivan Dědek, Petr Jakubec, Vojtěch Kupka, Vítězslav Hrubý, Martin Petr, Michal Otyepka
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An enzymatically activated AND-gate DNA logic circuit for tumor cells recognition via multi-microRNAs detection Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Hanrong Yan, Guojun Cao, Jin Wang, Xu Zhu, Shuqing Dong, Yuqi Huang, Minghao Chao, Yuting Li, Fenglei Gao, Lei Hua
The DNA-based logic circuit, constructed to mimic biochemical reaction networks, is highly significant in detecting biomarkers at the molecular level. The differences in the expression levels of microRNAs (miRNAs) within different types of cells provide hope for distinguishing cell subtypes. However, reliance on a single miRNA often leads to unreliable results. Herein, we constructed an enzyme-triggered
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Perovskite hydroxide-based laccase mimics with controllable activity for environmental remediation and biosensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Yufeng Liu, Jing Zhang, Shuai Cui, Hui Wei, Dongzhi Yang
Constructing relatively inexpensive nanomaterials to simulate the catalytic performance of laccase is of great significance in recent years. Although research on improving laccase-like activity by regulating ligands of copper (amino acids or small organic molecules, etc.) have achieved remarkable success. There are few reports on improving laccase-like activity by adjusting the composition of metal
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A photoelectrochemical biosensor based on self-calibration platform of carbon-rich plasmonic probe with near-infrared driving signal amplification Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-07 Yanjie Chen, Yitian Huang, Shupei Zhang, Lihong Gao, Hong Dai
Exploring the photochemical (PEC) method induced by low-energy light source makes great significance to achieve high stability and accurate analysis. A sensing platform driven by near-infrared (NIR) light was designed by making the biochemically encoded carbon rich plasmonic hybrid (CPH) probe, the peptide@C–MoC. The inherent plasmonic effect of C–MoC CPH can directly absorb NIR light, thus starting
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Highly sensitive and selective demethylase FTO detection using a DNAzyme-mediated CRISPR/Cas12a signal cascade amplification electrochemiluminescence biosensor with C–CN/PCNV heterojunction as emitter Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-06 Hong Li, Shuai Qiao, Heng Zhang, Yanxia Qiao, Jin Liu, Yan Li
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Metabolism-triggered sensor array aided by machine learning for rapid identification of pathogens Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-06 Xin Wang, Huida Li, Chengxin Wu, Jianyu Yang, Jianhua Wang, Ting Yang
Chemical-nose strategy has achieved certain success in the discrimination and identification of pathogens. However, this strategy usually relies on non-specific interactions, which are prone to be significantly disturbed by the change of environment thus limiting its practical usefulness. Herein, we present a novel chemical-nose sensing approach leveraging the difference in the dynamic metabolic variation
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MXene/Hydrogel-based bioelectronic nose for the direct evaluation of food spoilage in both liquid and gas-phase environments Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Jing Liu, Youngju Nam, Danmin Choi, Yoonji Choi, Sang-Eun Lee, Honggyu Oh, Guangxian Wang, Seung Hwan Lee, Yuan Liu, Seunghun Hong
Various bioelectronic noses have been recently developed for mimicking human olfactory systems. However, achieving direct monitoring of gas-phase molecules remains a challenge for the development of bioelectronic noses due to the instability of receptor and the limitations of its surrounding microenvironment. Here, we report a MXene/hydrogel-based bioelectronic nose for the sensitive detection of liquid
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Detection of SARS-CoV-2 using machine learning-enabled paper-assisted ratiometric fluorescent sensors based on target-induced magnetic DNAzyme Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Wenhai Wang, Lun Luo, Yanmei Li, Bin Hong, Yi Ma, Keren Kang, Jufang Wang
The development of an advanced analytical platform with regard to SARS-CoV-2 is crucial for public health. Herein, we present a machine learning platform based on paper-assisted ratiometric fluorescent sensors for highly sensitive detection of the SARS-CoV-2 RdRp gene. The assay involves target-induced rolling circle amplification to generate magnetic DNAzyme, which is then detectable using the paper-assisted
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Hepatocellular carcinoma biomarkers screening based on hydrogel photonic barcodes with tyramine deposition amplified ELISA Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Wenjing Xue, Li Wang, Kexin Yi, Lingyu Sun, Haozhen Ren, Feika Bian
Hepatocellular carcinoma (HCC), as one of the most lethal cancers, significantly impacts human health. Attempts in this area tends to develop novel technologies with sensitive and multiplexed detection properties for early diagnosis. Here, we present novel hydrogel photonic crystal (PhC) barcodes with tyramine deposition amplified enzyme-linked immunosorbent assay (ELISA) for highly sensitive and multiplexed
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Coreactant-free aggregation-induced electrochemiluminescence system based on the novel zinc-luminol metal-organic gel for ultrasensitive detection of PiRNA-823 Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-04 Congyi Hu, Liping Cao, Xinjie Wu, Gaoxu Chen, Yuanfang Li, Jian Wang, Chengzhi Huang, Lei Zhan
Aggregation-induced electrochemiluminescence (AIECL) technology has aroused widespread interest due to the significant improve in ECL response by solving the problems of aggregation-caused quenching and poor water solubility of the luminophore. However, the existing AIECL emitters still suffer from low ECL efficiency, additional coreactants and complex synthesis steps, which greatly limit their applications
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Construction of self-enhanced luminescence probes based on Ti3C2 reducibility for ultrasensitive PNK analysis Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-03 Zhihao Wei, Huixin Zhang, Feifei Zhang, Jianfei Xia, Qingyang Meng, Hongjie Huang, Zonghua Wang
Au nano-clusters (Au NCs) were promising electrochemiluminescence (ECL) nano-materials. However, the small size of Au NCs presented a challenge in terms of their immobilization during the construction of an ECL biosensing platform. This limitation significantly hindered the wider application of Au NCs in the ECL field. In this work, we successfully used the reducibility of TiC to fabricate a self-enhanced
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Two-dimensional metal-organic framework nanozyme-mediated portable paper-based analytical device for dichlorophen assay Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-03 Jiafu Chang, Ruixian Hu, Jinyan Zhang, Ting Hou, Feng Li
The metal-organic frameworks (MOFs) nanozyme-mediated paper-based analytical devices (PADs) have shown great potential in portable visual determination of phenolic compounds in the environment. However, most MOF nanozymes suffer from poor dispersibility and block-like structure, which often prompts deposition and results in diminished enzymatic activity, severely hindering their environmental applications
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High-throughput visualization mutation screening technology to enhance the specificity of CadR based whole-cell cadmium biosensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-02 Mingzhang Guo, Shijing Chen, Hongfei Su, Xiaolin Chen, Huilin Liu, Baoguo Sun
As a heavy metal pollutant, Cd often enters the human body through the food chain causing great harm to human health. Whole-cell biosensor is an emerging technology for rapid on-site detection of heavy metals with the advantages of inexpensive, fast to mass-produce, and strong in anti-interference resistance, but suffering from insatisfactory specificity. In this study, a strategy of Adjacent Site
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Flexible low-profile external ventricular drain catheter for real-time brain monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-02 Hoon Yi, Hodam Kim, Ka Ram Kim, Ju Hyeon Kim, Juhee Kim, Hyunjae Lee, Sanjeet S. Grewal, William D. Freeman, Woon-Hong Yeo
External ventricular drainage is one of the most common neurosurgical procedures in the world for acute hydrocephalus, which must be performed carefully by a neurosurgeon. Although various neuromonitoring external ventricular drain (EVD) catheters have been utilized, they still suffer from rigidity and bulkiness to mitigate post-EVD placement trauma. Here, we introduce a flexible and low-profile smart
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Nanozyme-assisted molecularly imprinted polymer-based indirect competitive ELISA for the detection of marine biotoxin Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-02 Chae Hwan Cho, Ji Hong Kim, Navnath S. Padalkar, Y. Veera Manohara Reddy, Tae Jung Park, Jinyoung Park, Jong Pil Park
Saxitoxin (STX), which is produced by certain dinoflagellate species, is a type of paralytic shellfish poisoning toxin that poses a serious threat to human health and the environment. Therefore, developing a technology for the convenient and cost-effective detection of STX is imperative. In this study, we developed an affinity peptide-imprinted polymer-based indirect competitive ELISA (ic-ELISA) without
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Fiber-optic immunosensor based on a Fabry–Perot interferometer for single-molecule detection of biomarkers Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-04-01 Haiming Qiu, Yong Yao, Yongkang Dong, Jiajun Tian
Immunosensors capable of ultralow-concentration and single-molecule detection of biomarkers are garnering attention for the early diagnosis of cancer. Herein, a fiber-optic Fabry–Perot interferometer (FPI)–based immunosensor was used for the first time for single-molecule detection of progastrin-releasing peptide (ProGRP). The cascaded FPI structure of the immunosensor introduces a high-order harmonic
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Advancing abiotic stress monitoring in plants with a wearable non-destructive real-time salicylic acid laser-induced-graphene sensor Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-31 Sammy A. Perdomo, Drochss Pettry Valencia, Gabriel Esteban Velez, Andres Jaramillo-Botero
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Ultrahigh peroxidase-like catalytic performance of Cu–N4 and Cu–N4S active sites-containing reduced graphene oxide for sensitive electrochemical biosensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-31 Phan Gia Le, Xuan Ai Le, Hai Sang Duong, Sung Hoon Jung, TaeYoung Kim, Moon Il Kim
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Automatic ultrasensitive lateral flow immunoassay based on a color-enhanced signal amplification strategy Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-30 Huiyang Jie, Yu Wang, Meng Zhao, Xiuzhen Wang, Zhong Wang, Lingliao Zeng, Xiaobao Cao, Tao Xu, Fan Xia, Qian Liu
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Modulus-tunable multifunctional hydrogel ink with nanofillers for 3D-Printed soft electronics Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-30 Minkyong Kang, Jae Park, Soo A Kim, Tae Young Kim, Ju Yeon Kim, Dae Woo Kim, Kijun Park, Jungmok Seo
Seamless integration and conformal contact of soft electronics with tissue surfaces have emerged as major challenges in realizing accurate monitoring of biological signals. However, the mechanical mismatch between the electronics and biological tissues impedes the conformal interfacing between them. Attempts have been made to utilize soft hydrogels as the bioelectronic materials to realize tissue-comfortable
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Biosensors for psychiatric biomarkers in mental health monitoring Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-29 Lin Wang, Yubing Hu, Nan Jiang, Ali K. Yetisen
Psychiatric disorders are associated with serve disturbances in cognition, emotional control, and/or behavior regulation, yet few routine clinical tools are available for the real-time evaluation and early-stage diagnosis of mental health. Abnormal levels of relevant biomarkers may imply biological, neurological, and developmental dysfunctions of psychiatric patients. Exploring biosensors that can
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A spatial-potential resolved bipolar electrode electrochemiluminescence biosensor based on polarity conversion for dual-mode detection of miRNA-122 and CEA Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Hongkun Li, Qianqian Cai, Zhikang Li, Guifen Jie, Hong Zhou
In this work, a spatial-potential resolved bipolar electrode electrochemiluminescence (BPE-ECL) biosensor based on polarity conversion strategy and CuHCF electrocatalyst was constructed for dual-mode detection of miRNA-122 and carcinoembryonic antigen (CEA). ECL technology was firstly used to systematically study the polarity conversion of BPE. It was found that changing the polarity of the driving
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Layer-by-layer growth of Cu3(HHTP)2 films on Cu(OH)2 nanowire arrays for high performance ascorbic acid sensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Chenhuinan Wei, Zhuo Wang, Yurun Hu, Jingqi Huang, Yang Zhang, Huihu Wang, Qiming Liu, Ziyang Yu
Growing three-dimensional (3D) metal organic frameworks (MOFs) via heterogeneous epitaxial growth on metal hydroxide arrays are effective for constructing electrochemical sensor. However, the growth of MOFs is difficult to control, resulting in thick and irregular morphologies and even damage the metal hydroxide template. In this work, Cu(HHTP) (HHTP = 2, 3, 6, 7, 10, 11-hexahydroxytriphenylene) films
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Dual toeholds regulated CRISPR-Cas12a sensing platform for ApoE single nucleotide polymorphisms genotyping Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Yuedong Zhu, Yanan Lin, Bin Gong, Yan Zhang, Gaoxing Su, Yanyan Yu
Single nucleotide polymorphisms (SNPs) are closely associated with many biological processes, including genetic disease, tumorigenesis, and drug metabolism. Accurate and efficient SNP determination has been proved pivotal in pharmacogenomics and diagnostics. Herein, a universal and high-fidelity genotyping platform is established based on the dual toeholds regulated Cas12a sensing methodology. Different
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Proximity labeling-assisted click conjugation for electrochemical analysis of specific subpopulations in circulating extracellular vesicles Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Yue Cao, Liang Zhou, Guozhang Zhou, Wensheng Liu, Haiyan Cui, Ya Cao, Xiaolei Zuo, Jing Zhao
Sensitive and accurate analysis of specific subpopulations in circulating extracellular vesicles (EVs) can provide a wealth of information for cancer diagnosis and management. Thus, we propose herein a new electrochemical biosensing method based on a proximity labeling-assisted click conjugation strategy. The method's core design is use of antibody-guided proximity labeling to equip target EVs with
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Fully integrated and automated centrifugal microfluidic chip for point-of-care multiplexed molecular diagnostics Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Yujin Xiao, Mengfan Zhou, Changgen Liu, Siyu Gao, Chao Wan, Shunji Li, Chenxi Dai, Wei Du, Xiaojun Feng, Yiwei Li, Peng Chen, Bi-Feng Liu
Public health events caused by pathogens have imposed significant economic and societal burdens. However, conventional methods still face challenges including complex operations, the need for trained operators, and sophisticated instruments. Here, we proposed a fully integrated and automated centrifugal microfluidic chip, also termed IACMC, for point-of-care multiplexed molecular diagnostics by harnessing
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Theory of nanostructured sensors integrated in/on microneedles for diagnostics and therapy Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Marco Fratus, Muhammad A. Alam
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Flexible microfluidic co-recognition coupled with magnetic enrichment and silent SERS sensing for simultaneous analysis of bacteria in food Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-28 Bingyang Huo, Ling Xia, Yuling Hu, Gongke Li
Food safety represents a critical global public health issue, with safety challenges posed by foodborne pathogens garnering extensive attention. Therefore, we introduce a co-recognition, enrichment and sensing (CES) all-in-one strategy for analysis of bacteria with low background and high specificity. This method employs antimicrobial peptide (AMP) functionalized magnetic nanoparticles (MNPs) to enrich
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Light-driven, bias-free nitrogenase-based bioelectrochemical cell for ammonia generation Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-27 Matan M. Meirovich, Oren Bachar, Mor Shemesh, Yifat Cohen, Alice Popik, Omer Yehezkeli
Nitrogen fixation is a key process that sustains life on Earth. Nitrogenase is the sole enzyme capable of fixing nitrogen under ambient conditions. Extensive research efforts have been dedicated to elucidating the enzyme mechanism and its artificial activation through high applied voltage, photochemistry, or strong reducing agents. Harnessing light irradiation to minimize the required external bias
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Nonwoven fiber meshes for oxygen sensing Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-27 Nikolaos Salaris, Wenqing Chen, Paul Haigh, Lorenzo Caciolli, Giovanni Giuseppe Giobbe, Paolo De Coppi, Ioannis Papakonstantinou, Manish K. Tiwari
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Development of a selective electrochemical microsensor based on molecularly imprinted polydopamine/ZIF-67/laser-induced graphene for point-of-care determination of 3-nitrotyrosine Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-26 Chibin Zheng, Ruwei Liu, Jianyue Chen, Shilin Li, Yunhan Ling, Zhengjun Zhang
3-nitrotyrosine (3-NT) is a biomarker closely associated with the early diagnosis of oxidative stress-related disorders. The development of an accurate, cost-effective, point-of-care 3-NT sensor holds significant importance for self-monitoring and clinical treatment. In this study, a selective, sensitive, and portable molecularly imprinted electrochemical sensor was developed. ZIF-67 with strong adsorption
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Bacterial detection based on Förster resonance energy transfer Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-26 Wanqing Zhang, Weiqiang Li, Yang Song, Qian Xu, Hengyi Xu
The huge economic loss and threat to human health caused by bacterial infection have attracted the public's concern, and there is an urgent need to relieve and improve the tough problem. Therefore, it is significant to establish a facile, rapid, and sensitive method for bacterial detection considering the shortcomings of existing methods. Förster resonance energy transfer (FRET)-based sensors have
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Improving trans-cleavage activity of CRISPR-Cas13a using engineered crRNA with a uridinylate-rich 5′-overhang Biosens. Bioelectron. (IF 12.6) Pub Date : 2024-03-25 Yihan Yang, Lingli Sun, Jianhong Zhao, Yang Jiao, Taoli Han, Xiaohong Zhou