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Brief Communication: Confocal microscopy of oral streptococcal biofilms grown in simulated microgravity using a random positioning machine npj Micrograv. (IF 4.4) Pub Date : 2024-09-09 Kelly C. Rice, Ke Aira T. Davis
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Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth npj Micrograv. (IF 4.4) Pub Date : 2024-08-21 Fay Ghani, Abba C. Zubair
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Author Correction: Hydrogel mechanical properties in altered gravity. npj Micrograv. (IF 4.4) Pub Date : 2024-08-21 Vanja Mišković,Immacolata Greco,Christophe Minetti,Francesca Cialdai,Monica Monici,Arianna Gazzi,Jeremiah Marcellino,Yarjan Abdul Samad,Lucia Gemma Delogu,Andrea C Ferrari,Carlo Saverio Iorio
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Functional activities essential for space exploration performed in partial gravity during parabolic flight npj Micrograv. (IF 4.4) Pub Date : 2024-08-17 Gilles Clément, Timothy R. Macaulay, Austin Bollinger, Hannah Weiss, Scott J. Wood
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Simulated microgravity impairs human NK cell cytotoxic activity against space radiation-relevant leukemic cells npj Micrograv. (IF 4.4) Pub Date : 2024-08-14 Bradford M. Kuhlman, Jonathan H. Diaz, Trang Simon, Kimberly D. Reeves, Stephen J. Walker, Anthony Atala, Graça Almeida-Porada, Christopher D. Porada
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Establishing a method for the cryopreservation of viable peripheral blood mononuclear cells in the International Space Station npj Micrograv. (IF 4.4) Pub Date : 2024-08-09 Hiroto Ishii, Rin Endo, Sanae Hamanaka, Nobuyuki Hidaka, Maki Miyauchi, Naho Hagiwara, Takahisa Miyao, Tohru Yamamori, Tatsuya Aiba, Nobuko Akiyama, Taishin Akiyama
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Hydrogel mechanical properties in altered gravity npj Micrograv. (IF 4.4) Pub Date : 2024-08-08 Vanja Mišković, Immacolata Greco, Christophe Minetti, Francesca Cialdai, Monica Monici, Arianna Gazzi, Jeremiah Marcellino, Yarjan Abdul Samad, Lucia Gemma Delogu, Andrea C. Ferrari, Carlo Saverio Iorio
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Light has a principal role in the Arabidopsis transcriptomic response to the spaceflight environment npj Micrograv. (IF 4.4) Pub Date : 2024-08-06 Mingqi Zhou, Robert J. Ferl, Anna-Lisa Paul
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Rotational and translational motions in a homogeneously cooling granular gas npj Micrograv. (IF 4.4) Pub Date : 2024-07-31 Torsten Trittel, Dmitry Puzyrev, Kirsten Harth, Ralf Stannarius
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Growth and mineralization of fetal mouse long bones under microgravity and daily 1 g gravity exposure npj Micrograv. (IF 4.4) Pub Date : 2024-07-27 Jack J. W. A. van Loon, Olga P. Berezovska, Theodorus J. M. Bervoets, Dina Montufar-Solis, Cor M. Semeins, Behrouz Zandieh-Doulabi, P. Natalia V. Rodionova, Jackie Duke, J. Paul Veldhuijzen
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Advancing insights into microgravity induced muscle changes using Caenorhabditis elegans as a model organism npj Micrograv. (IF 4.4) Pub Date : 2024-07-26 Laura J. Beckett, Philip M. Williams, Li Shean Toh, Volker Hessel, Lukas Gerstweiler, Ian Fisk, Luis Toronjo-Urquiza, Veeren M. Chauhan
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Expiration analysis of the International Space Station formulary for exploration mission planning npj Micrograv. (IF 4.4) Pub Date : 2024-07-23 Thomas E. Diaz, Emma C. Ives, Diana I. Lazare, Daniel M. Buckland
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Thermodynamic assessment of evaporation during molten steel testing onboard the International Space Station npj Micrograv. (IF 4.4) Pub Date : 2024-07-19 Jannatun Nawer, Brian Stanford, Matthias Kolbe, Stephan Schneider, Stéphane Gossé, Rainer K. Wunderlich, Markus Mohr, Aurelio Borzì, Antonia Neels, Douglas M. Matson
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Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment npj Micrograv. (IF 4.4) Pub Date : 2024-07-19 Jessica L. Braun, Val A. Fajardo
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Modeling cellular responses to serum and vitamin D in microgravity using a human kidney microphysiological system npj Micrograv. (IF 4.4) Pub Date : 2024-07-09 Kevin A. Lidberg, Kendan Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang, James W. MacDonald, Theo K. Bammler, Justina Calamia, Kenneth E. Thummel, Catherine K. Yeung, Stefanie Countryman, Paul Koenig, Jonathan Himmelfarb, Edward J. Kelly
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Demonstration for cold atmospheric pressure plasma jet operation and antibacterial action in microgravity npj Micrograv. (IF 4.4) Pub Date : 2024-07-06 A. Rouillard, P. Escot Bocanegra, A. Stancampiano, S. Dozias, J. Lemaire, J. M. Pouvesle, E. Robert, F. Brulé-Morabito, M. Demasure, S. Rouquette
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A meta-analysis of semiconductor materials fabricated in microgravity npj Micrograv. (IF 4.4) Pub Date : 2024-06-26 Ashley R. Wilkinson, Frances Brewer, Hannah Wright, Ben Whiteside, Amari Williams, Lynn Harper, Anne M. Wilson
This meta-analysis of 160 semiconductor crystals that were grown in microgravity on orbital vehicles between 1973 and 2016 is based on publicly available information documented in the literature. This analysis provides comparisons of crystal metrics including size, structure quality, uniformity, and improved performance between crystals grown in microgravity or terrestrially. Improvement in at least
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Evaluation of body shape as a human body composition assessment in isolated conditions and remote environments npj Micrograv. (IF 4.4) Pub Date : 2024-06-24 Michael C. Wong, Jonathan P. Bennett, Lambert T. Leong, Yong E. Liu, Nisa N. Kelly, John Cherry, Kate Kloza, Bosco Li, Sandra Iuliano, Jean Sibonga, Aenor Sawyer, Jeff Ayton, John A. Shepherd
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Weightlessness leads to an increase granulosa cells in the growing follicle npj Micrograv. (IF 4.4) Pub Date : 2024-06-22 Anna Yu. Kikina, Mariia S. Matrosova, Elena Yu. Gorbacheva, Ksenia K. Gogichaeva, Konstantin A. Toniyan, Valery V. Boyarintsev, Oleg V. Kotov, Irina V. Ogneva
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Machine learning workflow for edge computed arrhythmia detection in exploration class missions npj Micrograv. (IF 4.4) Pub Date : 2024-06-22 Cyril Mani, Tanya S. Paul, Patrick M. Archambault, Alexandre Marois
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Physical exercise restores adult neurogenesis deficits induced by simulated microgravity npj Micrograv. (IF 4.4) Pub Date : 2024-06-21 Alexandra Gros, Fandilla Marie Furlan, Vanessa Rouglan, Alexandre Favereaux, Bruno Bontempi, Jean-Luc Morel
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Dry immersion rapidly disturbs iron metabolism in men and women: results from the VIVALDI studies npj Micrograv. (IF 4.4) Pub Date : 2024-06-15 Mathieu Horeau, Nastassia Navasiolava, Angelique Van Ombergen, Marc-Antoine Custaud, Adrien Robin, Martine Ropert, Inês Antunes, Marie-Pierre Bareille, Rebecca Billette De Villemeur, Guillemette Gauquelin-Koch, Frédéric Derbré, Olivier Loréal
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Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: proof of concept npj Micrograv. (IF 4.4) Pub Date : 2024-06-11 Khaled Y. Kamal, Mariam Atef Othman, Joo-Hyun Kim, John M. Lawler
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Influence of the spaceflight environment on macrophage lineages npj Micrograv. (IF 4.4) Pub Date : 2024-06-11 Rocky An, Virginia Katherine Blackwell, Bijan Harandi, Alicia C. Gibbons, Olivia Siu, Iris Irby, Amy Rees, Nadjet Cornejal, Kristina M. Sattler, Tao Sheng, Nicholas C. Syracuse, David Loftus, Sergio R. Santa Maria, Egle Cekanaviciute, Sigrid S. Reinsch, Hami E. Ray, Amber M. Paul
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Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes npj Micrograv. (IF 4.4) Pub Date : 2024-06-11 Hari Ilangovan, Prachi Kothiyal, Katherine A. Hoadley, Robin Elgart, Greg Eley, Parastou Eslami
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Characterizing dehydration in short-term spaceflight using evidence from Project Mercury npj Micrograv. (IF 4.4) Pub Date : 2024-06-11 Robert J. Reynolds, Mark Shelhamer, Erik L. Antonsen, William R. Carpentier
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Ocular perfusion pressure is not reduced in response to lower body negative pressure npj Micrograv. (IF 4.4) Pub Date : 2024-06-08 Eric A. Hall, Richard S. Whittle, Ana Diaz-Artiles
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Cold atom microwave clock based on intracavity cooling in China space station npj Micrograv. (IF 4.4) Pub Date : 2024-06-06 Siminda Deng, Wei Ren, Jingfeng Xiang, Jianbo Zhao, Lin Li, Di Zhang, JinYin Wan, Yanling Meng, XiaoJun Jiang, Tang Li, Liang Liu, Desheng Lü
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Demonstration of charge-hold-vent (CHV) and no-vent-fill (NVF) in a simulated propellent storage tank during tank-to-tank cryogen transfer in microgravity npj Micrograv. (IF 4.4) Pub Date : 2024-06-06 J. N. Chung, Jun Dong, Hao Wang, Bo Han Huang, Jason Hartwig
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Spaceflight on the ISS changed the skeletal muscle proteome of two astronauts npj Micrograv. (IF 4.4) Pub Date : 2024-06-05 Marta Murgia, Jörn Rittweger, Carlo Reggiani, Roberto Bottinelli, Matthias Mann, Stefano Schiaffino, Marco V. Narici
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Effect of artificial gravity on neurocognitive performance during head-down tilt bedrest npj Micrograv. (IF 4.4) Pub Date : 2024-06-05 Borbála Tölgyesi, Anna Altbäcker, Irén Barkaszi, Tim Stuckenschneider, Leonard Braunsmann, Endre Takács, Bea Ehmann, László Balázs, Vera Abeln
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Transcranial magnetic stimulation as a countermeasure for behavioral and neuropsychological risks of long-duration and deep-space missions npj Micrograv. (IF 4.4) Pub Date : 2024-05-28 Afik Faerman, Derrick M. Buchanan, Nolan R. Williams
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Acute cardiovascular and muscular response to rowing ergometer exercise in artificial gravity – a pilot trial npj Micrograv. (IF 4.4) Pub Date : 2024-05-23 Timo Frett, Leo Lecheler, Michael Arz, Willi Pustowalow, Guido Petrat, Florian Mommsen, Jan Breuer, Marie-Therese Schmitz, David Andrew Green, Jens Jordan
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Inspiration4 data access through the NASA Open Science Data Repository npj Micrograv. (IF 4.4) Pub Date : 2024-05-14 Lauren M. Sanders, Kirill A. Grigorev, Ryan T. Scott, Amanda M. Saravia-Butler, San-huei Lai Polo, Rachel Gilbert, Eliah G. Overbey, JangKeun Kim, Christopher E. Mason, Sylvain V. Costes
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Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog npj Micrograv. (IF 4.4) Pub Date : 2024-05-13 Guy Trudel, Daniel Stratis, Lynda Rocheleau, Martin Pelchat, Odette Laneuville
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Development of a kidney microphysiological system hardware platform for microgravity studies npj Micrograv. (IF 4.4) Pub Date : 2024-05-11 Kendan A. Jones-Isaac, Kevin A. Lidberg, Catherine K. Yeung, Jade Yang, Jacelyn Bain, Micaela Ruiz, Greta Koenig, Paul Koenig, Stefanie Countryman, Jonathan Himmelfarb, Edward J. Kelly
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Unraveling dispersion and buoyancy dynamics around radial A + B → C reaction fronts: microgravity experiments and numerical simulations npj Micrograv. (IF 4.4) Pub Date : 2024-05-09 Yorgos Stergiou, Darío M. Escala, Paszkál Papp, Dezső Horváth, Marcus J. B. Hauser, Fabian Brau, Anne De Wit, Ágota Tóth, Kerstin Eckert, Karin Schwarzenberger
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Water droplet evaporation in varied gravity and electric fields npj Micrograv. (IF 4.4) Pub Date : 2024-05-07 M. J. Gibbons, A. I. Garivalis, S. M. O’Shaughnessy, A. J. Robinson, P. Di Marco
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Simulated lunar microgravity transiently arrests growth and induces osteocyte-chondrocyte lineage differentiation in human Wharton’s jelly stem cells npj Micrograv. (IF 4.4) Pub Date : 2024-05-04 Arjunan Subramanian, Chelsea Han Lin IP, Wei Qin, Xiawen Liu, Sean W.D. Carter, Gokce Oguz, Adaikalavan Ramasamy, Sebastian E. Illanes, Arijit Biswas, Gabriel G. Perron, Erin L. Fee, Sarah W. L. Li, Michelle K.Y. Seah, Mahesh A. Choolani, Matthew W. Kemp
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How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems? npj Micrograv. (IF 4.4) Pub Date : 2024-05-01 Craig R. G. Willis, Marco Calvaruso, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Eugénie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Francesca Cialdai, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl’Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky
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NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions npj Micrograv. (IF 4.4) Pub Date : 2024-04-26 Konstantinos I. Adamopoulos, Lauren M. Sanders, Sylvain V. Costes
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Systematic review of the effectiveness of standalone passive countermeasures on microgravity-induced physiologic deconditioning npj Micrograv. (IF 4.4) Pub Date : 2024-04-25 Syed Shozab Ahmed, Nandu Goswami, Adam Sirek, David Andrew Green, Andrew Winnard, Leonie Fiebig, Tobias Weber
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Modeling the impact of thoracic pressure on intracranial pressure npj Micrograv. (IF 4.4) Pub Date : 2024-04-10 Drayton W. Munster, Beth E. Lewandowski, Emily S. Nelson, R. K. Prabhu, Jerry G. Myers Jr
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Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice npj Micrograv. (IF 4.4) Pub Date : 2024-04-04 Yan Zhang, Lei Zhao, Yeqing Sun
Transcriptome profiles are sensitive to space stressors and serve as valuable indicators of the biological effects during spaceflight. Herein, we transformed the expression profiles into gene interaction patterns by single-sample networks (SSNs) and performed the integrated analysis on the 301 spaceflight and 290 ground control samples, which were obtained from the GeneLab platform. Specifically, an
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RNA-seq analysis in simulated microgravity unveils down-regulation of the beta-rhizobial siderophore phymabactin npj Micrograv. (IF 4.4) Pub Date : 2024-04-03 Daphné Golaz, Chad K. Papenfuhs, Paula Bellés-Sancho, Leo Eberl, Marcel Egli, Gabriella Pessi
Exploiting the symbiotic interaction between crops and nitrogen-fixing bacteria is a simple and ecological method to promote plant growth in prospective extraterrestrial human outposts. In this study, we performed an RNA-seq analysis to investigate the adaptation of the legume symbiont Paraburkholderia phymatum STM815T to simulated microgravity (s0-g) at the transcriptome level. The results revealed
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Spaceflight effects on human vascular smooth muscle cell phenotype and function npj Micrograv. (IF 4.4) Pub Date : 2024-03-28 Marina M. Scotti, Brandon K. Wilson, Jodi L. Bubenik, Fahong Yu, Maurice S. Swanson, Josephine B. Allen
The cardiovascular system is strongly impacted by the hazards of spaceflight. Astronauts spending steadily increasing lengths of time in microgravity are subject to cardiovascular deconditioning resulting in loss of vascular tone, reduced total blood volume, and diminished cardiac output. Appreciating the mechanisms by which the cells of the vasculature are altered during spaceflight will be integral
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Orbital Reef and commercial low Earth orbit destinations—upcoming space research opportunities npj Micrograv. (IF 4.4) Pub Date : 2024-03-29 Luis Zea, Liz Warren, Tara Ruttley, Todd Mosher, Laura Kelsey, Erika Wagner
As the International Space Station comes to the end of a transformative era of in-space research, NASA’s Commercial Low Earth Orbit (LEO) Destinations (CLD) Program aims to catalyze a new generation of platforms with co-investment from the private sector, preventing a potential gap in research performed in LEO, while building a robust LEO economy. In this paper, we provide insight into the CLD Program
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Effect of 60 days of head down tilt bed rest on amplitude and phase of rhythms in physiology and sleep in men npj Micrograv. (IF 4.4) Pub Date : 2024-03-29 María-Ángeles Bonmatí-Carrión, Nayantara Santhi, Giuseppe Atzori, Jeewaka Mendis, Sylwia Kaduk, Derk-Jan Dijk, Simon N. Archer
Twenty-four-hour rhythms in physiology and behaviour are shaped by circadian clocks, environmental rhythms, and feedback of behavioural rhythms onto physiology. In space, 24 h signals such as those associated with the light-dark cycle and changes in posture, are weaker, potentially reducing the robustness of rhythms. Head down tilt (HDT) bed rest is commonly used to simulate effects of microgravity
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SANS-CNN: An automated machine learning technique for spaceflight associated neuro-ocular syndrome with astronaut imaging data npj Micrograv. (IF 4.4) Pub Date : 2024-03-28 Sharif Amit Kamran, Khondker Fariha Hossain, Joshua Ong, Nasif Zaman, Ethan Waisberg, Phani Paladugu, Andrew G. Lee, Alireza Tavakkoli
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Substrate metabolism in male astronauts onboard the International Space Station: the ENERGY study npj Micrograv. (IF 4.4) Pub Date : 2024-03-27 Elisa Le Roux, Alexandre Zahariev, Isabelle Chery, Dale A. Schoeller, Pierre Bourdier, Alain Maillet, Cecile Thevenot, Maël Garnotel, Guillemette Gauquelin-Koch, Laurie Van Den Berghe, Stéphane Blanc, Chantal Simon, Audrey Bergouignan
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Long non-coding RNA-NONMMMUT004552.2 regulates the unloading-induced bone loss through the miRNA-15b-5p/Syne1 in mice npj Micrograv. (IF 4.4) Pub Date : 2024-03-23 Zheng Zhang, Yu Jing, Ang Zhang, JiShan Liu, Heming Yang, Xiaotong Lou, Liyan Xu, Min Liu, Yikun Zhang, Jianwen Gu
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Cooling of a granular gas mixture in microgravity npj Micrograv. (IF 4.4) Pub Date : 2024-03-22 Dmitry Puzyrev, Torsten Trittel, Kirsten Harth, Ralf Stannarius
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Cellular mechanotransduction of human osteoblasts in microgravity npj Micrograv. (IF 4.4) Pub Date : 2024-03-21 Nadab H. Wubshet, Grace Cai, Samuel J. Chen, Molly Sullivan, Mark Reeves, David Mays, Morgan Harrison, Paul Varnado, Benjamin Yang, Esmeralda Arreguin-Martinez, Yunjia Qu, Shan-Shan Lin, Pamela Duran, Carlos Aguilar, Shelby Giza, Twyman Clements, Allen P. Liu
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Cryogenic propellant management in space: open challenges and perspectives npj Micrograv. (IF 4.4) Pub Date : 2024-03-20 Alessia Simonini, Michael Dreyer, Annafederica Urbano, Francesco Sanfedino, Takehiro Himeno, Philipp Behruzi, Marc Avila, Jorge Pinho, Laura Peveroni, Jean-Baptiste Gouriet
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Levels of evidence for human system risk evaluation npj Micrograv. (IF 4.4) Pub Date : 2024-03-20 Jessica Ward, Robert J. Reynolds, Erin Connell, Wilma Anton, Avalon Kabeel, Jacqueline M. Charvat, Nicholas Nartey, Kristina Marotta, Ahmed Abukmail, Dan M. Buckland, Mary Van Baalen, Erik Antonsen
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Causal diagramming for assessing human system risk in spaceflight npj Micrograv. (IF 4.4) Pub Date : 2024-03-19 Erik Antonsen, Robert J. Reynolds, Jacqueline Charvat, Erin Connell, Avalon Monti, Devan Petersen, Nicholas Nartey, Wilma Anton, Ahmed Abukmail, Kristina Marotta, Mary Van Baalen, Daniel M. Buckland
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Autophagy formation, microtubule disorientation, and alteration of ATG8 and tubulin gene expression under simulated microgravity in Arabidopsis thaliana npj Micrograv. (IF 4.4) Pub Date : 2024-03-18 Alla Yemets, Ruslana Shadrina, Rostyslav Blume, Svitlana Plokhovska, Yaroslav Blume
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Future opportunities in solar system plasma science through ESA’s exploration programme npj Micrograv. (IF 4.4) Pub Date : 2024-03-14 Mats Holmstrom, Mark Lester, Beatriz Sanchez-Cano
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Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity npj Micrograv. (IF 4.4) Pub Date : 2024-03-15 François-Xavier Lehr, Bruno Pavletić, Timo Glatter, Thomas Heimerl, Ralf Moeller, Henrike Niederholtmeyer
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The effects of long-term exposure to microgravity and body orientation relative to gravity on perceived traveled distance npj Micrograv. (IF 4.4) Pub Date : 2024-03-13 Björn Jörges, Nils Bury, Meaghan McManus, Ambika Bansal, Robert S. Allison, Michael Jenkin, Laurence R. Harris