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Unraveling resistance mechanisms in combination therapy: A comprehensive review of recent advances and future directions Heliyon (IF 4.0) Pub Date : 2024-03-11 Nami Morales-Durán, Angel León-Buitimea, José R. Morones-Ramírez
Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are the main drivers in developing drug-resistant bacteria. The emergence of the rapid global spread of multi-resistant bacteria requires urgent multisectoral action to generate novel treatment alternatives. Combination therapy offers the potential to exploit synergistic effects for enhanced antibacterial efficacy
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Mapping the 5-HTergic neural pathways in perimenopausal mice and elucidating the role of oestrogen receptors in 5-HT neurotransmission Heliyon (IF 4.0) Pub Date : 2024-03-11 Hanfei Wang, Yanrong Sun, Wenjuan Wang, Xiangqiu Wang, Jinglin Zhang, Yu Bai, Ke Wang, Liju Luan, Junhao Yan, Lihua Qin
Perimenopausal syndrome (PMS) encompasses neuropsychiatric symptoms, such as hot flashes and depression, which are associated with alterations in the 5-HTergic neural pathway in the brain. However, the specific changes and mechanisms underlying these alterations remain unclear. In this study, ovariectomized mice were used to successfully establish a perimenopause model, and the changes in the expression
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From pandemic to endemic: Divergence of COVID-19 positive-tests and hospitalization numbers from SARS-CoV-2 RNA levels in wastewater of Rochester, Minnesota Heliyon (IF 4.0) Pub Date : 2024-03-11 Ramanath Majumdar, Biruhalem Taye, Corey Bjornberg, Matthew Giljork, Danielle Lynch, Fadumasahra Farah, Intisar Abdullah, Kristin Osiecki, Iris Yousaf, Aaron Luckstein, Wendy Turri, Priya Sampathkumar, Ann M. Moyer, Benjamin R. Kipp, Roberto Cattaneo, Caroline R. Sussman, Chanakha K. Navaratnarajah
Traditionally, public health surveillance relied on individual-level data but recently wastewater-based epidemiology (WBE) for the detection of infectious diseases including COVID-19 became a valuable tool in the public health arsenal. Here, we use WBE to follow the course of the COVID-19 pandemic in Rochester, Minnesota (population 121,395 at the 2020 census), from February 2021 to December 2022.
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Artemisinin and its derivatives as promising therapies for autoimmune diseases Heliyon (IF 4.0) Pub Date : 2024-03-11 Kaidi Xie, Zhen Li, Yang Zhang, Hao Wu, Tong Zhang, Wen Wang
Artemisinin, a traditional Chinese medicine with remarkable antimalarial activity. In recent years, studies demonstrated that artemisinin and its derivatives (ARTs) showed anti-inflammatory and immunoregulatory effects. ARTs have been developed and gradually applied to treat autoimmune and inflammatory diseases. However, their role in the treament of patients with autoimmune and inflammatory diseases
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Towards the prospect of carbon-neutral power system 2060: A Power-Meteorology-Society systematic view Heliyon (IF 4.0) Pub Date : 2024-03-11 Hao Ming, Mingyi Lin, Ciwei Gao, Ning Zhang, Le Xie, Yuting Mou
—With the target of achieving carbon peaking and neutrality in the power sector in China, both State Grid and China Southern Power Grid have made plans of a rapid increase of renewables in future years towards 2060. However, considering the interactions between the power system and meteorological, society factors, whether those plans would lead to CO emission peak in 2030 and carbon neutrality in 2060
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Lower serum uric acid and impairment of right cerebral hemisphere structural brain networks are related to depressive symptoms in cerebral small vessel disease: A cross-sectional study Heliyon (IF 4.0) Pub Date : 2024-03-11 Lei Yu, Ming Yi, Jiayu Guo, Jinbiao Li, Huixing Zeng, Liqian Cui, Xiangming Xu, Gang Liu, Yuhua Fan, Jinsheng Zeng, Shihui Xing, Yicong Chen, Meng Wang, Shuangquan Tan, Leow Yi Jin, Dilip Kumar, Ashwati Vipin, Soo See Ann, Fatin Zahra Binte Zailan, Gurveen Kaur Sandhu, Nagaendran Kandiah, Chao Dang
Cerebral small vessel disease (SVD) may be associated with an increased risk of depressive symptoms. Serum uric acid (SUA), an antioxidant, may be involved in the occurrence and development of depressive symptoms, but the mechanism remains unknown. Moreover, the relationship between structural brain networks and SUA has not been explored. This study examined the relationship between SUA and depressive
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Digitalization and SMEs development in the context of sustainable development: A China perspective Heliyon (IF 4.0) Pub Date : 2024-03-11 Ilknur Ozturk, Omaima Alqassimi, Sana Ullah
Worldwide economies are determined to achieve sustainable development. In this pursuit, the role of SMEs and ICT has emerged as an inevitable choice for sustainable development. The literature on the impact of SMEs and ICT on sustainable development, particularly in China's context, is scarce. Therefore, the analysis aims to investigate the impact of SMEs and ICT on sustainable development in China
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Attitude towards consent-free research use of personal medical data in the general German population Heliyon (IF 4.0) Pub Date : 2024-03-11 Gesine Richter, Nourane Trigui, Amke Caliebe, Michael Krawczak
The design of appropriate consent procedures for the secondary use of personal health data is a key concern of current medical research. In Germany, the concept of ‘data donation’ has recently come into focus, defined as a legal entitlement to the research use of personal medical data without prior consent, combined with an easy-to-exercise right of the data subjects to opt-out. Standardized online
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Genomic analysis of seven mycobacteriophages identifies three novel species with differing phenotypic stabilities Heliyon (IF 4.0) Pub Date : 2024-03-11 Laura M. O'Connell, Aidan Coffey, Jim M. O'Mahony
Recently, case studies have been published regarding the application of mycobacteriophage (MP) therapy (MPT) in patients with multi-antibiotic-resistant infections. A major limitation in the development of MPT is the paucity of therapeutically useful MP. As there are approximately 10,000 MP that have yet to be sequenced, it is possible that characterization of this cohort would increase the repertoire
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The impact of economic uncertainty on bank efficiency—the moderating role of country governance Heliyon (IF 4.0) Pub Date : 2024-03-11 Heng Luo, Fakarudin Kamarudin, Normaziah Mohd Nor
This study examined the impact of economic uncertainty (EU) on Islamic banks (IBs) and conventional banks' (CBs) efficiency in countries that meet a standard where 1% share of Islamic banking assets is part of their total domestic banking sector assets. In addition, this study explored the moderating effect of country governance (CG) by employing the quantitative methodology based on secondary data
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The nonlinear impact of financial flexibility on corporate sustainability: Empirical evidence from the Chinese manufacturing industry Heliyon (IF 4.0) Pub Date : 2024-03-11 Xiaojuan Sheng, Yuxiang An
In the face of challenges ushered in by globalization and technological advancements, financial flexibility has emerged as a pivotal strategy for attaining sustainable development in China's manufacturing sector. Financial flexibility allows firms to manage internal cash flows, alleviate external financing constraints, and augment their capability to absorb risks. Using the framework of Financial Flexibility
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People are an organic unity: Gut-lung axis and pneumonia Heliyon (IF 4.0) Pub Date : 2024-03-11 Jing Guo, Le Wang, Ningxin Han, Caiyun Yuan, Yujie Yin, Tongxing Wang, Jiemeng Sun, Peipei Jin, Yi Liu, Zhenhua Jia
People are an organic unity. Every organ of our body doesn't exist alone. They are a part of our body and have important connections with other tissues or organs. The gut-lung axis is a typical example. Here, we reviewed the current research progress of the gut-lung axis. The main cross-talk between the intestine and lungs was sorted out, i.e. the specific interaction content contained in the gut-lung
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Surface activation of Hastalex by vacuum argon plasma for cytocompatibility enhancement Heliyon (IF 4.0) Pub Date : 2024-03-11 Nikola Slepičková Kasálková, Silvie Rimpelová, Cyril Vacek, Dominik Fajstavr, Václav Švorčík, Petr Sajdl, Petr Slepička
Here, we present surface analysis and biocompatibility evaluation of novel composite material based on graphene oxide traded as Hastalex. First, the surface morphology and elemental analysis of the pristine material were examined by atomic force and scanning electron microscopies, and by energy-dispersive and X-ray photoelectron spectroscopies, respectively. The Hastalex surface was then modified by
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Assessment of the radionuclide remediation potential of novel miscanthus hybrids Heliyon (IF 4.0) Pub Date : 2024-03-11 Vanja Jurišić, Davor Rašeta, Mislav Kontek, John Clifton-Brown, Luisa M. Trindade, Isabelle Lamy, Annie Guerin, Andreas Kiesel, Ana Matin, Tajana Krička, Branko Petrinec
There are few studies related to the radionuclide remediation options, which comply to the demands of the environmentally non-destructive physical remediation methods. So far, most of the research was conducted on the phytoremediation capacity of different energy crops, as well as the established miscanthus hybrids which involved metal and heavy metal contaminants. Hence, the objective of this research
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A metamaterial unit-cell based patch radiator for brain-machine interface technology Heliyon (IF 4.0) Pub Date : 2024-03-11 Emtiaz Ahmed Mainul, Md Faruque Hossain
This paper presents a novel approach to the design of a brain implantable antenna tailored for brain-machine interface (BMI) technology. The design is based on a U-shaped unit-cell metamaterial (MTM), introducing innovative features to enhance performance and address specific challenges associated with BMI applications. The motivation behind the use of the unit-cell structure is to elongate the electric
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The oncogene MYBL2 promotes the malignant phenotype and suppresses apoptosis through hedgehog signaling pathway in clear cell renal cell carcinoma Heliyon (IF 4.0) Pub Date : 2024-03-11 Wenjie Yang, Hualin Chen, Lin Ma, Mengchao Wei, Xiaoqiang Xue, Yingjie Li, Zhaoheng Jin, Jie dong, He Xiao
Multiple cancers have been associated with MYB-related protein B (MYBL2), its involvement in clear cell renal cell carcinoma (ccRCC) has yet to be demonstrated. Our study revealed a significant upregulation of MYBL2 in ccRCC tissues, correlating with clinicopathological features and patient prognosis. Increased MYBL2 expression promoted cell proliferation and suppressed apoptosis. RNA-seq analysis
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Hidden blood loss and its influencing factors after cement augmentation for vertebral metastasis Heliyon (IF 4.0) Pub Date : 2024-03-11 Zhenguo Zhao, Shuguang Zhang, Libin Xu, Songfeng Xu, Xinxin Zhang, Ting Liu, Xuan Liu, Shengji Yu
Few studies have focused on the risk factors for hidden blood loss (HBL) during cement augmentation surgery for pathologic vertebral compression fraction (PVCFs). From January 2014 to December 2020, the clinical data of 169 PVCF patients (283 levels) who underwent cement augmentation were retrospectively analysed. HBL was calculated according to the linear Gross formula using the patient's average
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Prognostic factors for postoperative papillary thyroid cancer with unexplained elevated Tg: A retrospective study Heliyon (IF 4.0) Pub Date : 2024-03-11 Chenghui Lu, Na Han, Jiao Li, Guoqiang Wang, Congcong Wang, Qiang Jia, Jian Tan, Xufu Wang, Zhaowei Meng
This study aimed to investigate the underlying reasons for unexplained elevated thyroglobulin (Tg) in postoperative papillary thyroid cancer (PTC) patients according to follow-up results post RAT and to explore the long-term clinical outcomes and prognostic factors associated with these patients. From April 2016 to June 2019, a retrospective study was conducted on postoperative PTC patients who underwent
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Insight on ecDNA-mediated tumorigenesis and drug resistance Heliyon (IF 4.0) Pub Date : 2024-03-11 Qing Huang, Su Zhang, Guosong Wang, Junhong Han
Extrachromosomal DNAs (ecDNAs) are a pervasive feature found in cancer and contain oncogenes and their corresponding regulatory elements. Their unique structural properties allow a rapid amplification of oncogenes and alter chromatin accessibility, leading to tumorigenesis and malignant development. The uneven segregation of ecDNA during cell division enhances intercellular genetic heterogeneity, which
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The relationship between mass customization and sustainable performance: The role of firm size and global E-commerce Heliyon (IF 4.0) Pub Date : 2024-03-11 Guan Hui, Abdullah Al Mamun, Mohammad Masukujjaman, Zafir Khan Mohamed Makhbul, Mohd Helmi Ali
The formation of mass customization competencies is crucial for the increasing number of manufacturing companies in modern times. This study assessed the relationship between mass customization capability and its determinants on sustainable performance. Additionally, it explores the mediating role of mass customization capability and sustainable performance, while also examining the moderating effects
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Polyphenol-rich black currant and cornelian cherry juices ameliorate metabolic syndrome induced by a high-fat high-fructose diet in Wistar rats Heliyon (IF 4.0) Pub Date : 2024-03-11 Marija Paunovic, Maja Milosevic, Olivera Mitrovic-Ajtic, Natasa Velickovic, Bojana Micic, Olgica Nedic, Vanja Todorovic, Vesna Vucic, Snjezana Petrovic
Diets high in fat and sugar lead to metabolic syndrome (MetS) and related chronic diseases. We investigated the effects of commercially available, cold-pressed polyphenol-rich black currant (BC) and cornelian cherry (CC) juices on the prevention of MetS in rats induced by a 10-week high-fat high-fructose (HFF) diet. Juice consumption, either BC or CC, with an HFF diet resulted in lower serum triglycerides
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Impact of natural disasters on student enrollment in higher education programs: A systematic review Heliyon (IF 4.0) Pub Date : 2024-03-11 J, i, n, g, , W, a, n, g
This study aims to evaluate how natural disasters affect student enrollment in higher education programs, considering both immediate and long-term consequences. The PRISMA guidelines were adhered to in conducting this review. Multiple databases, such as Web of Science and Scopus, including those with articles from January 2000 to February 2023, were thoroughly searched. Articles focusing on how natural
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Downstaging guided neoadjuvant strategy shift and bladder preservation in locally advanced bladder cancer: A case report Heliyon (IF 4.0) Pub Date : 2024-03-11 Gan Du, Zhichao Jiang, Wang Qu, Jin Zhang, Shan Zheng, Yueping Liu, Aiping Zhou, Hongzhe Shi, Jianzhong Shou
The study of bladder preservation for muscle-invasive bladder cancer (MIBC) mainly focuses on the T2 stage, which remains difficult in the T3 and T4 stage. Pembrolizumab has been applied as neoadjuvant therapy followed by radical cystectomy for MIBC, gaining encouraging results in the phase II study. Disitamab vedotin, an antibody-drug conjugate (ADC), also achieved promising efficacy for refractory
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Differential clinical outcomes after 3 versus 5 years in a comparison of preoperative chemotherapy with and without radiotherapy in locally advanced rectal cancer: A national cohort propensity score-matched study Heliyon (IF 4.0) Pub Date : 2024-03-11 Yuanxin Zhang, Rui Luo, Jingqi Peng, Zichuan He, Delin Tan, Xueping Liu, Hui Wang, Huaiming Wang
Preoperative chemotherapy alone might be a good alternative to preoperative chemoradiotherapy for patients with locally advanced rectal cancer, yet long-term real-world data from the same cohort are lacking. Patients diagnosed with stage II-III rectal adenocarcinoma from 2011 to 2015 were randomly sampled from the SEER-Plus database to evaluate the superiority of preoperative chemoradiotherapy versus
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Spatial patterns, factors, and ethnic differences: A study on ethnic minority villages in Yunnan, China Heliyon (IF 4.0) Pub Date : 2024-03-11 Wenjing Gao, Xiaolan Zhuo, Dawei Xiao
This paper takes ethnic minority villages in Yunnan province of China, which have significant characteristics of multi-ethnic integration, as the research object. Through various spatial statistical analysis methods, we analyzed the overall distribution characteristics of ethnic villages in Yunnan, the distribution difference among various ethnic groups, and the influencing factors of the distribution
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Gamo's cultural forum-Dubussha as a tool for social change communication: Illiteracy and child labor abuse as a case in point Heliyon (IF 4.0) Pub Date : 2024-03-11 Mekonen Teka Ayalew, Tafesse Walea Wanke
This study investigated the instrumental potential of Gamo's traditional dialogue forum-Dubussha-for social change communication in general, using illiteracy and child labour abuse as a case in point. The study went on to analyze the motive that when traditions pave the way for new ways of life and thinking, changes are more applicable and transformative. As a result, this study sought to apply current
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Risk assessment of driver performance in the oil and gas transportation industry: Analyzing the relationship between driver vigilance, attention, reaction time, and safe driving practices Heliyon (IF 4.0) Pub Date : 2024-03-11 Al-Baraa Abdulrahman Al-Mekhlafi, Ahmad Shahrul Nizam Isha, Nicholas Chileshe, Ahmed Farouk Kine-ber, Muhammad Ajmal, Abdullah O. Baarimah, Al-Hussein M.H. Al-Aidrous
The increasing use of road traffic for land transportation has resulted in numerous road accidents and casualties, including those involving oil and gas tanker vehicles. Despite this, little empirical research has been conducted on the factors influencing tanker drivers' performance. This study aims to address this knowledge gap, particularly in the energy transportation industry, by examining the
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In-silico characterization of LSDV132 protein divulged its BCL-2-like nature Heliyon (IF 4.0) Pub Date : 2024-03-11 Muhammad Farhan Sarwar, Qurat ul Ain Waseem, Mudassar Fareed Awan, Sajed Ali, Ajaz Ahmad, Saif ul Malook, Qurban Ali
Lumpy skin disease virus (LSDV) belongs to family. This virus possesses various proteins which impart potential functions to it including assembly of newly synthesized viruses in the replication cycle and forming their structure. LSDV132 protein is also one of such proteins. Its key characteristics were unknown because, no any relevant study was reported about it. This study aimed to investigate its
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Ivermectin for treatment of COVID-19: A systematic review and meta-analysis Heliyon (IF 4.0) Pub Date : 2024-03-11 Zhilong Song, Senyuan Shi, Yongli Zhang
The effect of ivermectin (IVM) in treating coronavirus disease 2019 (COVID-19) is still controversial, yet the drug has been widely used in the world. The aim of this review was to systematically evaluate the clinical outcomes of IVM in patients with COVID-19. From inception to June 22, 2023, the PubMed, EMBASE, Web of Science (WOS), and scopus databases were searched for relevant observational studies
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Impact of the addition of dexmedetomidine to patient-controlled intravenous analgesia on postoperative pain-sleep interaction cycle and delirium: A systematic review and meta-analysis of randomized controlled trials Heliyon (IF 4.0) Pub Date : 2024-03-11 Wenjie Xu, Yuxiang Zheng, Qing Wang, Zizheng Suo, Lingling Fang, Jing Yang, Shuai Li, Peng Li, Xixi Jia, Xiaoyan Liu, Hui Zheng, Cheng Ni
The reciprocal nexus between sleep and pain is well-documented, with the deleterious impact of operative trauma potentially playing a pivotal role in the dysregulation of this interplay, which could significantly contribute to the manifestation of postoperative delirium (POD). Studies have investigated the effect of adding dexmedetomidine (DEX) to patient-controlled intravenous analgesia (PCIA) pumps
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Using person reported outcomes: Psychometric properties of the German diabetes treatment satisfaction questionnaire (DTSQ) for teens and parents Heliyon (IF 4.0) Pub Date : 2024-03-11 Su-Jong Kim-Dorner, Heike Saßmann, Bettina Heidtmann, Thomas M. Kapellen, Olga Kordonouri, Karolin M.E. Krosta, Roland Schweizer, Simone von Sengbusch, Karin Lange
To examine psychometric properties including the factor structure of the German versions of the Diabetes Treatment Satisfaction Questionnaire for teens and parents (DTSQ-T/-P). Linguistically validated questionnaires were completed by 363 adolescents with type 1 diabetes and 655 parent-caregivers in a multicenter study. Confirmatory factor analysis (CFA), reliability, and correlations were examined
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Explaining uncertainty in women's fertility preferences Heliyon (IF 4.0) Pub Date : 2024-03-11 Amke M.G. van Tintelen, Gert Stulp
People's fertility preferences are often considered an important determinant of fertility. What is often neglected in studies of preferred fertility, is the uncertainty that people may have about their preferences. In this study, using data on Dutch women through the Longitudinal Internet studies for the Social Sciences (collected early 2018), we examined women's fertility preferences and asked detailed
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Repurposing of Food and Drug Admnistration (FDA) approved library to identify a potential inhibitor of trypanothione synthetase for developing an antileishmanial agent Heliyon (IF 4.0) Pub Date : 2024-03-11 Divya Vemula, Shreelekha Mohanty, Vasundhra Bhandari
Leishmaniasis is one of the top 10 neglected tropical diseases. Globally, it impacts more than 12 million individuals. In light of the absence of a safer, affordable treatment for the Leishmaniasis, along with therapeutic failures and drug resistance, novel therapeutic strategies are necessary to discover new drugs. Treatment would benefit by concentrating on the precise targets that are crucial for
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Comparison of three VST orthokeratology lenses in axial length growth and average corneal reshaping in myopia children: A retrospective self-controlled study Heliyon (IF 4.0) Pub Date : 2024-03-11 Anken Wang, Wansheng Zang, Li Shen, Lu Gao, Chenhao Yang
To determine the differences in myopia control efficiency and corneal reshaping between three different brands of orthokeratology (OK) lenses (Lucid, Euclid, and Alpha). We retrospectively reviewed subjects who started simultaneously using different brands of OK lenses. For each participant, every 6 months in the 19 months of following, the changes in axial length (AL), horizontal and vertical maximum
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Exercise capacity-hemodynamics mismatch in elderly patients with pulmonary hypertension: A nationwide multicenter study from Taiwan Society of Cardiology Pulmonary Hypertension Registry (TAIPANS) Heliyon (IF 4.0) Pub Date : 2024-03-11 Chang-Ying Chen, Wang Mei-Tzu, Shih-Hsien Sung, Yih-Jer Wu, Chih-Hsin Hsu, Wan-Jing Ho, Yen-Hung Lin, Wei-Shin Liu, Ju-Chi Liu, Yung-Ta Kao, Wen-Shiann Wu, Chun-Hsien Wu, Meng-Huan Lei, Yu-Wei Chen, Chien Chen-Yu, Yu-Wei Chiu, Zen-Kong Dai, Tsung-Hsien Lin, Lin Lin, Cheng-Chih Chung, Chang-Min Chung, Sung-Hao Huang, Chin-Chang Cheng, Yen-Wen Wu, Ting-Hsing Chao, Juey-Jen Hwang, Charles Jia-Yin Hou
Demographics of pulmonary hypertension (PH) has changed a lot over the past forty years. Several recent registries noted an increase in mean age of PH but only a few of them investigated the characteristics of elderly patients. Thus, we aimed to analyze the characteristics of PH in such a population in this study. This multicenter study enrolled patients diagnosed with PH in group 1, 3, 4, and 5 consecutively
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Application of the superior mesenteric artery-first approach in laparoscopic pancreatoduodenectomy: A literature review Heliyon (IF 4.0) Pub Date : 2024-03-11 Jianji Ke, Feiqi Liu, Jianjia Ke, Hongqiao Cai, Yahui Liu, Bai Ji
Laparoscopic pancreaticoduodenectomy (LPD) is a complicated surgical procedure that has recently been performed safely. A superior mesenteric artery (SMA)-first approach can allow complete mesopancreas resection, maximizing surgical margins and R0 resection rates. Therefore, the SMA-first approach is recommended. This review is a literature summary of recent updates of the SMA approaches for LPD and
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Magnetic susceptibility in the assessment of toxic heavy metal elements in the surface sediments of Inner Ambon Bay, Maluku province, Indonesia Heliyon (IF 4.0) Pub Date : 2024-03-11 Yohansli Noya, Satria Bijaksana, Silvia Jannatul Fajar, Putu Billy Suryanata, Ulvienin Harlianti, Khalil Ibrahim, Ni Komang Tri Suandayani, Warni Multi, Samsul Bahri
The Inner Ambon Bay (IAB) is an important area for the economic development of the city of Ambon, one of only a few urban areas in eastern Indonesia. This study is intended to monitor the anthropogenic impact on IAB by employing combined rock magnetic and geochemical analyses on 20 samples collected from IAB and the surrounding rivers. Magnetic susceptibility values of samples in the IAB averaged 26
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Advancing sanitary surveillance: Innovating a live-feed sewer monitoring framework for effective water level and chamber cover detections Heliyon (IF 4.0) Pub Date : 2024-03-11 Yelbek Utepov, Alexandr Neftissov, Timoth Mkilima, Zhanbolat Shakhmov, Sungat Akhazhanov, Alizhan Kazkeyev, Assel Toleubekovna Mukhamejanova, Aigul Kenzhebekkyzy Kozhas
Efficient sanitation system management relies on vigilant sewage surveillance to uphold environmental hygiene. The absence of robust monitoring infrastructure jeopardizes unimpeded conduit flow, leading to floods and contamination. The accumulation of harmful gases in sewer chambers, coupled with tampered lids, compounds sewer network challenges, resulting in structural damage, disruptions, and safety
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Low expression of RACK1 is associated with metastasis and worse prognosis in cholangiocarcinoma Heliyon (IF 4.0) Pub Date : 2024-03-11 Zhihui Gao, Wentao Sun, Xiaojian Ni, Wenze Wan, Tao Suo, Xiaoling Ni, Han Liu, Na Li, Sheng Shen, Houbao Liu
Cholangiocarcinoma is a poorly prognostic malignant tumor, and the metastatic stage of cancer is not an early stage when diagnosed. Lymph node metastasis is common in the early stage. Ribosomal receptor for activated C-kinase 1 (RACK1) has found involved in the oncogenesis of various tumors and in the epithelial-mesenchymal transition (EMT). Nevertheless, its role in cholangiocarcinoma remains unknown
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Identification of different subtypes of ovarian cancer and construction of prognostic models based on glutamine-metabolism associated genes Heliyon (IF 4.0) Pub Date : 2024-03-11 Xie Yaqing, Gao Yang, Yang Linlin, Ruan Youqing, Yang Henghui, Yang Ping, Yang Hongying, Shaojia Wang
Ovarian cancer (OC) is common malignant tumor of female reproductive system. Glutamine metabolism-related genes (GMRGs) play a key role in ovarian cancer. Here, available database-- The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO) databases were applied in our research. OC samples from TCGA were divided into different clusters based on Cox analysis
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Photocatalytic degradation of acid yellow 36 with calcined titania-hydroxyapatite-cuo xerogels Heliyon (IF 4.0) Pub Date : 2024-03-11 S.López Ayala, C. Menchaca Campos, M.E. Rincón, C.A. García Pérez, J. Uruchurtu
Advanced oxidation processes (AOP), using semiconductor (SC) and hydroxyapatite (HA) composites, are promising due to the synergy of photocatalytic and adsorption properties. Still, dye removal efficiency of composites based on HA-SC remains low, because most of the research reported consider single SC materials. In this work, nanocrystalline xerogels of titanium oxide (TiO2) with copper oxide (CuO)
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“Salicylic acid enhances thermotolerance and antioxidant defense in Trigonella foenum graecum L. under heat stress” Heliyon (IF 4.0) Pub Date : 2024-03-11 Sana Choudhary, Towseef Mohsin Bhat, Khairiah Mubarak Alwutayd, Diaa Abd El-Moneim, Neha Naaz
Plants possess various defense mechanisms to cope with genotoxic and environmental challenges, with high temperatures posing a significant threat due to global warming. In this investigation, ten-day-old (fenugreek) seedlings were cultivated in a controlled environment chamber with conditions set at 70–80% relative humidity, a day/night cycle of 25/18 °C, and a photosynthetically active radiation (PAR)
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A nonsense CC2D1A variant is associated with congenital anomalies, motor delay, hypotonia, and slight deformities Heliyon (IF 4.0) Pub Date : 2024-03-11 Sheng Yi, Xianglian Tang, Qiang Zhang, Yu Liang, Jing Huang, Shujie Zhang, Limei Huang, Shang Yi, Minpan Huang, Zailong Qin, Jingsi Luo
Autosomal recessive intellectual developmental disorder-3 is caused by homozygous or compound heterozygous mutations in the gene. The disorder is characterized by intellectual disability (ID) and autism spectrum disorder (ASD). To date, 39 patients from 17 families with -related disorders have been reported worldwide, in whom only six pathogenic or likely pathogenic loss-of-function variants and three
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The occurrence and development of abdominal aortic aneurysm may be related to the energy metabolism disorder and local inflammation Heliyon (IF 4.0) Pub Date : 2024-03-11 Jun Li, Yang Liu, Zhitao Wei, Jie Cheng, Yongfa Wu
The cellular mechanism of the formation of abdominal aortic aneurysm (AAA) is very complicated. A series of sophisticated events eventually led to significant pathological changes in the anatomical structure and function of the arterial wall and they are still not clear nowadays. We pooled publicly available GEO datasets (GSE57691 and GSE47472) to get a comprehensive comparisons between normal tissues
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Carveol mitigates the development of the morphine anti-nociceptive tolerance, physical dependence, and conditioned place preference in mice Heliyon (IF 4.0) Pub Date : 2024-03-11 Ismail Badshah, Neelum Gul Qazi, Maira Anwar, Bushra Shaukat, Muhammad Imran Khan, Babar Murtaza
Emergence of analgesic tolerance and dependence to morphine is frequently the limiting factor in the use of this agent in the management of pain. Hence, this study aimed to investigate the beneficial effects of the natural compound carveol (CV) against morphine antinociceptive tolerance, dependence and conditioned place preference (CPP) in mice. Behavioural paradigms included hot plate and tail-flick
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Advancing cancer theranostics through biomimetics: A comprehensive review Heliyon (IF 4.0) Pub Date : 2024-03-11 Kuttiappan Anitha, Santenna Chenchula, Vijayaraj Surendran, Bhatt Shvetank, Parameswar Ravula, Rhythm Milan, Radhika Chikatipalli, Padmavathi R
Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation of diagnostics and therapeutics, known as cancer theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers a multidisciplinary avenue with potential in advancing cancer theranostics. This review comprehensively
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Translating microcalcification biomarker information into the laboratory: A preliminary assessment utilizing core biopsies obtained from sites of mammographic calcification Heliyon (IF 4.0) Pub Date : 2024-03-11 Iain D. Lyburn, Robert Scott, Eleanor Cornford, Pascaline Bouzy, Nicholas Stone, Charlene Greenwood, Ihsanne Bouybayoune, Sarah E. Pinder, Keith Rogers
The potential of breast microcalcification chemistry to provide clinically valuable intelligence is being increasingly studied. However, acquisition of crystallographic details has, to date, been limited to high brightness, synchrotron radiation sources. This study, for the first time, evaluates a laboratory-based system that interrogates histological sections containing microcalcifications. The principal
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Sugar-coated bullets: Unveiling the enigmatic mystery ‘sweet arsenal’ in osteoarthritis Heliyon (IF 4.0) Pub Date : 2024-03-11 Hong-zhi Liu, Xin-qiu Song, Hongmei Zhang
Glycosylation is a crucial post-translational modification process where sugar molecules (glycans) are covalently linked to proteins, lipids, or other biomolecules. In this highly regulated and complex process, a series of enzymes are involved in adding, modifying, or removing sugar residues. This process plays a pivotal role in various biological functions, influencing the structure, stability, and
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Psychological readiness of football players for the match and its connection with self-esteem and competitive anxiety Heliyon (IF 4.0) Pub Date : 2024-03-11 A, d, r, i, a, n, a, , K, a, p, l, á, n, o, v, á
For athletes, failure in a match is psychologically difficult. Since the movement abilities of athletes are often comparable, it is assumed that one of the key elements of victory is also their psychological readiness. Many experts recommend rigorously examining all factors affecting the performance of football players, especially in matches. The aim of our study is to determine whether a football
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Association of lipopolysaccharide with new-onset atrial fibrillation in ST-segment elevation myocardial infarction Heliyon (IF 4.0) Pub Date : 2024-03-11 Honglong Ren, Zhonghua Wang, Yong Li, Jinqi Liu
Lipopolysaccharide (LPS) is related to various cardiovascular diseases. However, the relationship between LPS and new-onset atrial fibrillation (NOAF) after ST-segment elevation myocardial infarction (STEMI) has yet to be elucidated. This study aimed to evaluate the impact of LPS on NOAF in STEMI patients. This was a single-center retrospective observational study including 806 patients diagnosed with
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Dose–response relationship of levodopa with dyskinesia in Parkinson's disease: A systematic review and meta-analysis Heliyon (IF 4.0) Pub Date : 2024-03-10 Taozhi He, Dai Wang, Xinyu Zhang, Jiawen Liu, Shiyu Fang, Zhe Zhang, Hongjie Liu
Despite existing evidence linking dyskinesia to levodopa, the primary treatment for Parkinson's, the dose–response relationship and risk factors remain uncertain. In this study, the risk for dyskinesia in patients with Parkinson's disease receiving levodopa was evaluated via meta-analysis and meta-regression approaches to examine dyskinesia risk factors more reliably and improve treatment strategies
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The influence of triglyceride and low-density-lipoprotein target levels on microcirculation: is there a difference? Heliyon (IF 4.0) Pub Date : 2024-03-10 Gergely Galos, Miklos Rabai, Reka Szabo, Rita Szalai, Kalman Toth, Peter Hegyi, Barbara Sandor
This study aimed to validate the role of high low-density lipoprotein cholesterol [LDL-C] and triglyceride [TG] treatment target levels on the microcirculation in a very high and high cardiovascular risk group. 119 patients with high or very high cardiovascular [CV] risk were included. We have registered the main co-morbidities, smoking habits, body mass index [BMI] and the lipid lowering medication
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Pallidal versus subthalamic deep brain stimulation for Meige syndrome: A systematic review and meta-analysis Heliyon (IF 4.0) Pub Date : 2024-03-10 Xin Wu, Tao Xue, Shiqing Pan, Weikang Xing, Chuanjun Huang, Jianguo Zhang, Guozheng Zhao
Globus pallidus internus (GPi) and subthalamic nucleus (STN) are two common deep brain stimulation (DBS) targets. This meta-analysis was to compared the efficacy and safety of these two DBS targets for the treatment of Meige syndrome (MS). A systematic search was performed using EMBASE, MEDLINE, the Cochrane Library, and to identify DBS trials for MS. Review Manager 5.3 was used to perform meta-analysis
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Treatment gaps in the care of amyotrophic lateral sclerosis in the Philippines: A scoping review Heliyon (IF 4.0) Pub Date : 2024-03-10 Iris D. Ditan, Christian Wilson R. Turalde
Amyotrophic lateral sclerosis (ALS) is a progressive disease affecting both the upper and lower motor neurons. Much of the management of ALS is supportive with the goal of maximizing patient quality of life. While the Philippines was participative in the “Ice Bucket Challenge” in 2014, it is up for investigation whether substantial changes occurred to improve healthcare for ALS patients. This study
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Risk factors and prediction models for cardiovascular complications of hypertension in older adults with machine learning: A cross-sectional study Heliyon (IF 4.0) Pub Date : 2024-03-10 Yixin Wu, Bo Xin, Qiuyuan Wan, Yanping Ren, Wenhui Jiang
Hypertension has emerged as a chronic disease prevalent worldwide that may cause severe cardiovascular complications, particularly in older patients. However, there is a paucity of studies that use risk factors and prediction models for cardiovascular complications associated with hypertension in older adults. To identify the risk factors and develop prediction models for cardiovascular complications
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Fibroblast growth factor 23 during septic shock and myocardial injury in ICU patients Heliyon (IF 4.0) Pub Date : 2024-03-10 Zheng Yang, Jie Wang, Jilin Ma, Danhong Ren, Zhihui Li, Kun Fang, Zhanli Shi
Fibroblast growth factor 23 (FGF23) has been recognized as an important biomarker of cardiovascular disease and is closely related to inflammation over the past decade. This study aimed to assess the relationship between FGF23 and myocardial injury in patients with sepsis. We sequentially measured serum FGF23, Klotho, biomarkers of inflammation (CRP, IL-6 and WBC), myocardial injury (cTnI and N-terminal
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Assessing the impact of emergency measures in varied population density areas during a large dengue outbreak Heliyon (IF 4.0) Pub Date : 2024-03-10 Chia-Hsien Lin, Tzai-Hung Wen
The patterns of dengue are affected by many factors, including population density and climate factors. Densely populated areas could play a role in dengue transmission due to increased human-mosquito contacts, the presence of more diverse and suitable vector habitats and breeding sites, and changes in land use. In addition to population densities, climatic factors such as temperature, relative humidity
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The role of the transcriptional repressor CssR in Corynebacterium glutamicum in response to phenolic compounds Heliyon (IF 4.0) Pub Date : 2024-03-10 Ju Zhang, Yuying Zhao, Zhaoxin Peng, MingFei Yang, Wenyu Zou, Xinyu Wu, Chenghui Wang, Meiru Si, Can Chen
The gene () of encodes a repressor of the TetR (tetracycline regulator) family. Its role in the stress response to antibiotics/heavy metals has been investigated, but how CssR functions in response to phenolic compounds in has been rarely studied. In this study, we applied transcriptomic analysis, β-galactosidase analysis, qRT-PCR, and EMSAs to analyze the target genes and functions of CssR in response
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Acute Coronary Artery Air Embolism Complicating a CT-guided percutaneous lung biopsy: A case report Heliyon (IF 4.0) Pub Date : 2024-03-10 Haotian Lu, Jieqiong Yu, Hongliang Sun, Shengtao Yan
Systemic air embolism is a fatal complication of computed tomography-guided percutaneous lung biopsy. Here, we report a case of acute coronary artery air embolism following computed tomography (CT) guided percutaneous lung biopsy. The patient exhibited cardiac symptoms, and CT showed air density in left ventricle and aorta, indicating air embolism. Trendelenburg positioning and coronary angiography
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Accounting for the health risk of probiotics Heliyon (IF 4.0) Pub Date : 2024-03-10 Xiangyi Liu, Haiyi Zhao, Aloysius Wong
Probiotics have long been associated with a myriad of health benefits, so much so that their adverse effects whether mild or severe, are often neglected or overshadowed by the enormous volume of articles describing their beneficial effects in the current literature. Recent evidence has demonstrated several health risks of probiotics that warrant serious reconsideration of their applications and further