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Fifty years of research on cannabidiol (CBD) as an anticonvulsant: The legacy of Brazilian groups. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-25 Antonio Waldo Zuardi,José Alexandre Crippa
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Yanomami Humanitarian Tragedy - An Urgent Colonial Heritage. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-23 Marcelo G Lima,Thiago M Fidalgo
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110 years of Karls Jaspers's book "Allgemeine Psychopathologie": is there still a role for Jaspers's phenomenological approach to psychopathology in the DSM era? Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-23 Paulo Marcos Brasil Rocha
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Risk factors for executive function impairment in adolescence: 2004 Pelotas Birth Cohort study. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-23 Júlia de Souza Rodrigues,Alicia Matijasevich,Luciana Tovo-Rodrigues,Tiago N Munhoz,Iná S Santos,Maria Pastor-Valero
OBJECTIVE To investigate risk factors associated with impaired attention-related executive functions (EFs) at age 11 and working memory at age 15. METHODS Data from the population-based 2004 Pelotas Birth Cohort was analyzed at ages 11 (N=3,582) and 15 (N=1,950). The study measured attentional control, cognitive flexibility, and selective attention using the Daily Attention Test for Children. Spatial
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Rural-urban disparities in the consumption of fruits and vegetables and cognitive performance in Brazil. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-23 Gomes Gonçalves,Laiss Bertola,Cleusa Pinheiro Ferri,Claudia Kimie Suemoto
OBJECTIVES Rural residents face many risk factors for poor diet quality, such as low socioeconomic status and food insecurity. However, differences in the association of fruit and vegetable consumption with cognitive performance in urban and rural areas have not been explored. The aim of this study was to investigate the association of fruit and vegetable consumption with cognitive performance in urban
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Cross-cultural Adaptation and Validity Evidence of the Mind-Wandering Questionnaire (MWQ) for Brazilian Portuguese. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-23 Franciele Cristiane Peloso,Murilo Ricardo Zibetti,Antonio Egidio Nardi,Ramiro Figueiredo Catelan
OBJECTIVE The objective of the present study is to adapt and present validity evidence based on the internal structure of the Mind-Wandering Questionnaire (MWQ) for the Brazilian context. METHODS A total of 2682 Brazilian adults from different regions of the country have taken part in this study. Confirmatory factor analyses and multigroup confirmatory factor analyses (MGCFA) were performed to assess
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Depressive Symptoms and Self-Rated Health among Brazilian Older Adults: Baseline Data from the Elsi Brazil Study. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-23 Natalia T Ito,Déborah Oliveira,Fabricio M S Rodrigues,Erico Castro-Costa,Maria F Lima-Costa,Cleusa P Ferri
OBJECTIVE This study investigates whether having a higher number of depressive symptoms is associated with negative self-rated health even in the presence of illnesses. METHODS This is a secondary analysis of the baseline data from the Longitudinal Study of the Health of Elderly Brazilians (ELSI - Brazil), conducted in 2015-2016, using a national sample of 9,412 people aged 50 or over. Self-rated health
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Sodium nitroprusside as an adjunctive treatment for schizophrenia reduces the Ndel1 oligopeptidase activity. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-23 João Victor Nani,Juliana Mayumi Ushirohira,Nicholas J Bradshaw,João Paulo Machado-de-Sousa,Jaime Eduardo Cecílio Hallak,Mirian A F Hayashi
OBJECTIVE Schizophrenia (SCZ) is a disabling disorder that continues to defy clinicians and researchers. We investigated the effects of sodium nitroprusside (sNP) in an animal model of SCZ and as an add-on therapy in patients and the relationship between treatment with sNP and activity of the nDel1 enzyme, whose involvement in the pathophysiology of the disorder has been suggested earlier. METHODS
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The association of Maternal Fears regarding their infants/toddlers during the COVID-19 pandemic, and Maternal Depression and Anxiety trajectories: a birth cohort study. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-13 Raquel Wermann Foschiera,Júlia Pustrelo Moro,Fabiana de Abreu Getulino,Marina Xavier Carpena,Francine Dos Santos Costa,Cauane Blumenberg,Rafaela Costa Martins,Thais Martins-Silva,Luana Patrícia Marmitt,Alejandra Goicochea,Rodrigo Meucci,Juraci Cesar,Christian Loret de Mola
OBJECTIVE Assess the association between maternal fears/worries regarding their infant's/toddler's, and maternal depression and anxiety trajectories during COVID-19. METHODS In 2019, all hospital births in Rio Grande (southern Brazil) were identified and mothers answered a standardized questionnaire (baseline). We followed them between May-June 2020 (1st follow-up), August-December 2020 (2nd follow-up)
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Brazilian Psychiatric Association guidelines for the treatment of generalized anxiety disorder (GAD). Pharmacological and Psychotherapy approach. Perspectives. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-11-13 Leonardo Baldaçara,Ana Beatriz Paschoal,Aldo Felipe Pinto,Fabiano Franca Loureiro,Luiz Antonio Vesco Gaiotto,Diogo de Lacerda Veiga,Thales Marcon Almeida,Diogo Cesar Dos Santos,Leandro Fernandes Malloy-Diniz,Marcelo Feijó de Mello,Andrea Feijó de Mello,Marsal Sanches,Lucas Marques Gandarela,Márcio Antonini Bernik,Antonio E Nardi,Antônio Geraldo da Silva,Ricardo R Uchida
OBJECTIVE To combine elements of a systematic review and critical review to produce best evidence synthesis for the treatament of GAD. METHOD There was included systematic reviews, metanalysis, and randomized controlled trials. Descriptor used was "generalized anxiety disorder", resulting in 4860 articles and 7 other studies, of which 59 were selected. RESULTS Antidepressants and benzodiazepines are
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Prediction of Declarative Memory Profile in Panic Disorder Patients: A Machine Learning-Based Approach. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-10-25 Felipe Dalvi-Garcia,Laiana Azevedo Quagliato,Donald J Bearden,Antonio Egidio Nardi
INTRODUCTION Panic disorder (PD) is common and defined by recurrent, unexpected panic attacks and persistent concern about additional attacks and their consequences. Anxiety affects declarative memory, which is important for reframing maladaptive thoughts and beliefs and learning healthy coping strategies. METHODS We developed random forest (RF) models to classify the declarative memory profile of
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Progressive multifocal leukoencephalopathy cannot be due to liver cirrhosis alone. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-10-25 Fulvio A Scorza,Josef Finsterer
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Discussing clozapine adverse effects and monitoring strategies: a focus on ethnic diversity. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-10-04 Ana Teresa Caliman-Fontes,Gustavo C Leal,Ary Gadelha,Lucas C Quarantini
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The best of two worlds: Combining the DSM-5 and ICD-11 clusters of symptoms for PTSD in a single screening scale. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-10-04 Alina Vasconcelos,Michael Reichenheim,Elizabeth do Nascimento,Eduardo Lima,Christian Kristensen,Mauro Mendlowicz
INTRODUCTION The most recent diagnostic criteria of DSM-5 (2013) and ICD-11 (2018) list PTSD encompasses 20 and 6 symptoms, respectively, organized in different structures. The study aimed to investigate the dimensions of the Posttraumatic Stress Disorder Checklist 5 according to the DSM-5's broader definition of PTSD and the ICD-11's narrower approach, as well as to explore an alternative restricted
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Treatment Resistance in Schizophrenia: a Meta-Analysis of Prevalences and Correlates. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Elton Diniz,Lais Fonseca,Deyvis Rocha,Alisson Trevizol,Raphael Cerqueira,Bruno Ortiz,André R Brunoni,Rodrigo Bressan,Christoph U Correll,Ary Gadelha
OBJECTIVE To define the prevalence and correlates of treatment-resistant schizophrenia (TRS) through a systematic review and meta-analysis. METHODS Following PRISMA criteria, an electronic search was performed in PubMed and EMBASE through May 17, 2022. All study designs that assessed a minimum of 20 schizophrenia-spectrum patients, providing data on TRS prevalence or allowing its calculation, were
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Professor Dr. Ellis Alindo D'Arrigo Busnello: a humanist and a scientist with a passion for psychiatry and psychopathology. A great mentor of Brazilian Psychiatric Scientific Post-Graduation Programs. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Flavio Kapczinski,Antonio E Nardi
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Brazilian Psychiatric Association Guidelines on the Integration of Spirituality into Mental Health Clinical Practice: Part 1. Spiritual History and Differential Diagnosis. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Bruno Paz Mosqueiro,Marianna de Abreu Costa,André C Caribé,Fabrício Oliveira de Oliveira,Leandro Pizutti,Rogério R Zimpel,Leonardo Baldaçara,Antônio Geraldo da Silva,Alexander Moreira-Almeida
OBJECTIVE To present an evidence-based guideline for clinical practice in Brazil with regard to religiosity and spirituality in mental healthcare. METHODS A systematic review was conducted to identify potentially eligible articles indexed in the PubMed, PsycINFO, SciELO, LILACS and Cochrane databases. A summary of recommendations and the level of evidence was produced in accordance with the Oxford
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Brazilian Journal of Psychiatry sustains its remarkable growth in 2023. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Antonio E Nardi,João Quevedo,Antonio Geraldo da Silva
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Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Gustavo Magno Baldin Tiguman,Rogério Hoefler,Vanessa Gomes Lima,Marcus Tolentino Silva,Inês Ribeiro-Vaz,Taís Freire Galvão
OBJECTIVE To estimate the prevalence of antidepressant use in Brazil. METHODS We conducted a systematic review with searches in MEDLINE, Embase, Scopus, LILACS, and SciELO up to May 2023. Two researchers independently selected studies, extracted data and assessed the methodological quality. We combined the prevalence of antidepressant use using meta-analyses of proportions by Freeman-Tukey and estimated
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Brazilian research consortium on obsessive-compulsive spectrum disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part II: Cognitive-Behavior Therapy treatment. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Maria Alice de Mathis,Priscila Chacon,Rodrigo Boavista,Marcos Vinícius Sousa de Oliveira,Pedro Macul Ferreira de Barros,Marco Antonio Nocito Echevarria,Ygor Arzeno Ferrão,Edoardo Felippo de Queiroz Vattimo,Antônio Carlos Lopes,Albina Rodrigues Torres,Juliana Belo Diniz,Leonardo Fontenelle,Maria Conceição do Rosário,Roseli Gedanke Shavitt,Renata de Melo Felipe da Silva,Eurípedes Constantino Miguel,Daniel
OBJECTIVE To summarize the evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). METHODS A systematic review of the literature on CBT interventions for the treatment of adult OCD, comprising behavior therapy and exposure and response prevention (ERP) was done. The objective of this study is to present
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Drug Overdose Deaths in Brazil between 2000 and 2020: an Analysis of Sociodemographics and Intentionality. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Marina Costa Moreira Bianco,Vitor S Tardelli,Emily Rose Brooks,Kelsy C N Areco,Adalberto O Tardelli,Paulo Bandiera-Paiva,Julian Santaella,Luis E Segura,João M Castaldelli-Maia,Silvia S Martins,Thiago M Fidalgo
OBJECTIVE The aim of the project was to examine drug overdose records in Brazil from 2000 to 2020 and analyze trends over time in overdoses and overall sociodemographic characteristics of the deceased. METHODS Using data from the Mortality Information System for Brazil, we identified records from 2000-2020 in which the underlying cause-of-death was one of the following codes: X40-X45 (accidental poisoning)
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Improvement of hedonic perception of odors as a marker of treatment response to Escitalopram - Olfactory changes through an open-label antidepressant trial. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 François Kazour,Boriana Atanasova,Thomas Desmidt,Valérie Gissot,Apolline Lefevre,Vincent Camus,Catherine Belzung,Wissam El-Hage
The aim of this study is to assess olfactory functions (Threshold, identification and hedonic valence) of depressed subjects before and after an 8-week Escitalopram trial, and compare the results of responders and non-responders to antidepressant. Fifty-two depressed subjects were recruited. Participants received Escitalopram with two evaluation visits, at baseline (V0) and at week 8 (V8). They were
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Is maintenance needed for patients who responded to acute TMS therapy? Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-09-17 Bashar Asir,Andrea Boscutti,João Quevedo
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A meta-analysis and electric field modeling to understand the antidepressant effects of tDCS. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-07-03 Lais B Razza,Miles Wischnewski,Paulo Suen,Stefanie De Smet,Pedro Henrique Rodrigues da Silva,Beatriz Catoira,André R Brunoni,Marie-Anne Vanderhasselt
Transcranial direct current stimulation (tDCS) presents mixed effects for major depressive disorder (MDD) symptoms, partially owing to a large inter-experimental variability in tDCS protocols and their correlated induced electric fields (E-fields). We investigated whether tDCS-induced E-field strength of distinct tDCS parameters was associated with antidepressant effect. A meta-analysis was performed
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Validity and Reliability of the Brazilian Version of the Cognitive Reserve Assessment Scale in Health (CRASH). Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-07-03 Joana Bücker,Silvia Amoretti,Eduard Vieta,Leticia Czepielewsk,Denise Scheibe,Bruno Braga Montezano,Jeferson Goularte,Adriane Rosa
OBJECTIVE As the elderly population increases, it is important to identify factors that may reduce risks of dementia in the general population. One such factor is the concept of cognitive reserve (CR). The present study analyzed the psychometric properties of the Cognitive Reserve Assessment Scale in Health (CRASH) in the Brazilian population, which was originally developed to measure CR in individuals
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Postpartum Psychosis: An Alternate Explanation for Symptom Specificity. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-07-03 Verinder Sharma,Dwight Mazmanian
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Changes and predictors of adolescent emotion regulation, selfesteem, and locus of control during the COVID-19 pandemic: the 2004 Pelotas Birth Cohort. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-07-03 Jessica Mayumi Maruyama,Luciana Tovo-Rodrigues,Iná S Santos,Joseph Murray,Alicia Matijasevich
OBJECTIVE There is a growing interest in examining the impacts of the COVID-19 pandemic on adolescent socioemotional development. This study aimed to examine changes in adolescent emotion regulation, self-esteem, and locus of control from before to during the pandemic in a Brazilian birth cohort, and to investigate the variables associated with changes in those socioemotional competences. METHODS 1
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Multidisciplinary contributions towards an evolutive interpretation of bipolar disorders: Could it be the pathological drift of a potentially adaptive condition? Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-06-12 Mauro Giovanni Carta,Antonio E Nardi,Samantha Pinna,Giulia Cossu,Oye Gureje
This paper tries to summarize the results of studies from different disciplines supporting the idea that temperamental traits, such as "reckless/hyper-exploratory" attitudes, commonly believed to be associated with psychopathology, surprisingly turn out as adaptive under specific stress conditions. In particular, this paper analyzes an ethologic line of research on primates suggesting models for a
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Emerging synthetic cannabinoids and the risk of psychosis: a growing concern for public health. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-06-12 José Diogo R Souza,Clarice S Madruga,Cristiano Noto
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Brazilian norms for Patient Health Questionnaire (PHQ-9): so near or not too close? Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-06-08 Yuan-Pang Wang,Clarice Gorenstein
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Comorbidity Patterns and Mortality Among Hospitalized Patients with Psychiatric Disorders and COVID-19. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-06-08 Marina Sánchez-Rico,Katayoun Rezaei,Alfonso Delgado-Álvarez,Frédéric Limosin,Nicolas Hoertel,Jesús M Alvarado
OBJECTIVE To examine the association between psychiatric and non-psychiatric comorbidity and 28-day mortality among patients with psychiatric disorders and COVID-19. METHODS We performed a multicenter observational retrospective cohort study of adult patients with psychiatric disorders hospitalized with laboratory-confirmed COVID-19 at 36 Greater Paris University hospitals (January 2020-May 2021) (N=3
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Dr. Raphael Mechoulam, cannabis and cannabinoids research pioneer (November 5, 1930-March 9, 2023) and his legacy for Brazilian pharmacology. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-27 José Alexandre S Crippa,Francisco S Guimarães,Antonio Waldo Zuardi,Jaime E C Hallak
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An MRI-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-27 Fernanda Rohrsetzer,Joana Bisol Balardin,Felipe Picon,João Ricardo Sato,Lucas Battel,Anna Viduani,Pedro Henrique Manfro,Leehyun Yoon,Brandon A Kohrt,Helen L Fisher,Valeria Mondelli,Johnna R Swartz,Christian Kieling
OBJECTIVE To explore differences in regional cortical morphometric structure between adolescents at risk for depression or with current depression. METHODS We analyzed cross-sectional structural neuroimaging data from a sample of 150 Brazilian adolescents classified as low-risk (n=50) or high-risk for depression (n=50) or with current depression (n=50) through a vertex-based approach with measurements
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Relative impact of diagnosis and clinical stage on response to electroconvulsive therapy: a retrospective cohort. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-27 Eduardo Tedeschi,Mauricio S Hoffmann,Pedro V S Magalhaes
OBJECTIVE Electroconvulsive therapy (ECT) is commonly indicated for refractory psychiatric disorders. However, response comparison across diagnoses is scantly investigated. Here, we aimed to evaluate the relative impact of diagnosis and clinical staging as response predictors in a cross-diagnostic sample. METHODS We investigate, in a retrospective cohort of adult inpatients (N=287) who underwent at
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Glymphatic system waste clearance and Alzheimer's disease. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-25 Joao Luis Barichello de Quevedo,Douglas Teixeira Leffa,Tharick A Pascoal
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Mass murders in Brazil: the rise of a tragic forensic and public health problem. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-25 Thiago Henrique Roza,Alexandre Martins Valença,Milena Ferreira de França Alexandre,Antônio Geraldo da Silva,Lisieux Elaine de Borba Telles
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Examining differences in brain metabolism associated with childhood maltreatment and suicidal attempt in euthymic patients with bipolar disorder: A PET and Machine Learning Study. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-11 Dante Duarte,Manuel Schütze,Mazen Elkhayat,Maila de Castro Neves,Marco A Romano-Silva,Humberto Correa
OBJECTIVE Childhood maltreatment (CM) is a significant risk factor for the development and severity of bipolar disorder (BD) with increased risk of suicide attempts (SA). This study evaluated whether a machine learning algorithm could be trained to predict if a patient with BD has a history of CM or previous SA based on brain metabolism measured by positron emission tomography. METHODS Thirty-six euthymic
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Is insulin resistance truly responsible for post-COVID depression? Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-01 Josef Finsterer,Carla Scorza
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When should a university student be allowed academic accommodation For ADHD? A position statement for a unified procedure for use in Brazil. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-01 Bernardo Oppermann Lisboa,Arthur Caye,Angelo Masson Hernandes,Antonio Geraldo da Silva,Carlos Roberto M Rieder,Edmund Sonuga-Barke,Iane Kestelman,Jason M Nelson,Marisa Irene Siqueira Castanho,Rochele Paz Fonseca,Stephen P Hinshaw,Luis Augusto Rohde
OBJECTIVE To identify under what circumstances a university student should be allowed academic accommodation for ADHD. To frame an evidence-based policy for use in Brazil based on a worldwide experience. METHODS We reviewed the literature to acquire information on what documents are commonly required by disability services before accommodation for ADHD is made (including malingering detection). We
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Increased insulin resistance is associated with depressive symptoms due to Long COVID. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-01 Michael Maes,Abbas F Almulla,Hussein Kadhem Al-Hakeim
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The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a systematic review and meta-analysis of cerebrospinal fluid studies. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-01 Mehmet Enes Inam,Brisa S Fernandes,Estela Salagre,Iria Grande,Eduard Vieta,João Quevedo,Zhongming Zhao
INTRODUCTION The kynurenine pathway has been attracting attention as a relevant pathway in schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD). We conducted a systematic review and meta-analysis of the kynurenine pathway metabolites from cerebrospinal fluid (CSF) samples in SZ, BD, and MDD. METHODS PubMed and Scopus databases were systematically searched to identify peer-reviewed
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Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-04-26 Graccielle R Cunha,Arthur Caye,Pedro Pan,Helen L Fisher,Rivka Pereira,Carolina Ziebold,Rodrigo Bressan,Eurípedes Constantino Miguel,Giovanni A Salum,Luis Augusto Rohde,Brandon A Kohrt,Valeria Mondelli,Christian Kieling,Ary Gadelha
OBJECTIVE The Identifying Depression Early in Adolescence Risk Score (IDEA-RS) was recently developed in Brazil using data from the Pelotas 1993 Birth Cohort to estimate the individualized probability of developing depression in adolescence. This model includes 11 sociodemographic variables and has been assessed in longitudinal studies from four other countries. We aimed to test the performance of
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Mapping the modulating effect of transcutaneous auricular vagus nerve stimulation on voxel-based analyses in patients with first-episode major depressive disorder: a resting-state functional magnetic resonance imaging study. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-11 Jia-Kai He,Shao-Yuan Li,Yu Wang,Bin Zhao,Xue Xiao,Xiao-Bing Hou,Shuai Zhang,Ya-Nan Zhao,Wei-Hang Zhai,Ji-Liang Fang,Pei-Jing Rong
INTRODUCTION Seed-based analysis has shown that transcutaneous auricular vagus nerve stimulation (taVNS) can modulate the dysfunctional brain network in patients with major depressive disorder (MDD). However, the voxel-based neuropsychological mechanism of taVNS on patients with first-episode MDD is poorly understood. The objective of this study was to assess the effects of an 8-week course of taVNS
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Overdose death rates in Brazil: an ecological analysis by region. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-04-04 Vitor S Tardelli,Marina C M Bianco,Rachel Patel,Kelsy C N Areco,Paulo Bandiera-Paiva,Adalberto O Tardelli,Luis E Segura,João M Castaldelli-Maia,Thiago M Fidalgo,Silvia S Martins
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Progressive multifocal leukoencephalopathy presenting with confusion and behavioral disturbances in an HIV-negative patient. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-04-04 Ana Isabel Almeida,José Maria Sousa,Sofia Vedor,Luís Augusto
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Tourette syndrome and multiple sclerosis: a case report. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-04-04 Francisco de Assis Aquino Gondim,Antônio Miguel Furtado Leitão,Leonardo José Rodrigues de Araújo Melo,Ineusi Teixeira de Araújo
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A dopamine receptor D2 genetic polymorphism associated with transition to mental disorders in a cohort of individuals with at-risk mental state for psychosis. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-04-04 Julia Hatagami Marques,Leda Leme Talib,Lucas Hortêncio,Julio Cesar Andrade,Tania Maria Alves,Mauricio Henriques Serpa,Guilherme Lopes Yamamoto,Martinus Theodorus van de Bilt,Wulf Rössler,Wagner Farid Gattaz,Alexandre Andrade Loch
OBJECTIVES To test the association of 45 single nucleotide polymorphisms (SNPs) with transition to psychiatric disorders in a cohort of individuals at ultrahigh risk (UHR) mental state for psychosis. METHODS Through general population screening, 88 non-help-seeking UHR subjects and 130 healthy control individuals were genotyped for 45 SNPs related to psychosis. They were followed for a mean of 2.5
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Climate awareness, anxiety, and actions among youth: a qualitative study in a middle-income country. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-04-04 Debora Tseng Chou,Emilio Abelama Neto,Isaiah Thomas,Andrés Martin,Laelia Benoit
OBJECTIVES The impact of climate change on mental health is well established, but few studies have examined the perspectives of young people, especially in low- and middle-income countries (LMICs). In this qualitative study, we explored how Brazilian children and adolescents experience climate change. This approach can help inform environmental education, communication, and self-care strategies for
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Translating measurement into practice: Brazilian norms for the Patient Health Questionnaire (PHQ-9) for assessing depressive symptoms. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-03-19 Rodolfo Furlan Damiano,Maurício Scopel Hoffmann,Natan Pereira Gosmann,Pedro Mario Pan,Eurípedes Constantino Miguel,Giovanni Abrahão Salum
OBJECTIVE To provide practical norms for measuring depressive symptoms using the Patient Health Questionnaire 9 (PHQ-9) in Brazil using a state-of-art psychometrics analysis. METHODS We used a large and representative Brazilian dataset from the 'Pesquisa Nacional de Saúde - 2019'(PNS-2019), which includes 90,846 Brazilian citizens. First, to assess the scale structure, we assessed the unidimensional
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The mirror neuron: thirty years since its discovery. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-03-14 Luiz Felipe Figueiredo,Maria Eduarda Lannes,Catia Mathias,Marleide Mota Gomes,Antonio E Nardi
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Lifetime cannabis use and childhood trauma associated with CNR1 genetic variants increase the risk of psychosis: findings from the STREAM study. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-03-14 Camila Marcelino Loureiro,Fabiana Corsi-Zuelli,Helene Aparecida Fachim,Rosana Shuhama,Adrielle Martins de Oliveira,Paulo Rossi Menezes,Caroline F Dalton,Paulo Louzada-Junior,Sintia Iole Belangero,Fernanda Coeli-Lacchini,Gavin P Reynolds,Riccardo Lacchini,Cristina Marta Del-Ben
OBJECTIVES Gene-environment interactions increase the risk of psychosis. The objective of this study was to investigate gene-gene and gene-environment interactions in psychosis, including single nucleotide variants (SNVs) of dopamine-2 receptor (D2R), N-methyl-d-aspartate receptor (NMDAR), and cannabinoid receptor type 1 (CB1R), lifetime cannabis use, and childhood trauma. METHODS Twenty-three SNVs
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Efficacy of bupropion and cognitive behavioral therapy in the treatment of methamphetamine use disorder: a systematic review and meta-analysis. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-03-14 Luis Fernando Maya Apuy,Marie Antouannet Bernabé Barreto,Luis Alejandro Hurtado Merino
OBJECTIVES We assessed the efficacy of cognitive behavioral therapy and bupropion compared to cognitive behavioral therapy alone for methamphetamine use disorder. METHODS The selection criteria for this systematic review study with meta-analysis were randomized clinical trials on the efficacy of cognitive behavioral therapy and bupropion in the treatment for methamphetamine use disorder (assessed by
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Guidelines for integrating spirituality into the prevention and treatment of alcohol and other substance use disorders. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-02-08 Alexandre de Rezende-Pinto,Alexander Moreira-Almeida
Alcohol and other substance use disorders are complex problems with multiple variables and determinants, requiring a multidimensional approach to prevention and treatment. A robust body of research shows that religiosity and spirituality (R/S) play a prominent role in these disorders; however, how to apply this knowledge remains unclear. We present practical guidelines on how to integrate R/S into
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CRISPR/Cas9 Genome Editing Approaches for Psychiatric Research. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-11 Araceli Gutiérrez-Rodríguez,Carlos S Cruz-Fuentes,Alma D Genis-Mendoza,Humberto Nicolini
Currently, genome editing technologies, such as clustered regularly interspaced short palindromic repeats (CRISPR/Cas9), are predominantly used to model genetic diseases. This genome editing system can correct point or frameshift mutations in risk genes. Here, we analyze and discuss the advantages of genome editing, its current applications, and the feasibility of the CRISPR/Cas9 system in research
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Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-11 Marcos Vinícius Sousa de Oliveira,Pedro Macul Ferreira de Barros,Maria Alice de Mathis,Rodrigo Boavista,Priscila Chacon,Marco Antonio Nocito Echevarria,Ygor Arzeno Ferrão,Edoardo Felippo de Queiroz Vattimo,Antônio Carlos Lopes,Albina Rodrigues Torres,Juliana Belo Diniz,Leonardo F Fontenelle,Maria Conceição do Rosário,Roseli Gedanke Shavitt,Eurípedes Constantino Miguel,Renata de Melo Felipe da Silva
OBJECTIVES To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). METHODS The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with
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Social cognition across bipolar disorder and behavioral variant frontotemporal dementia: an exploratory study. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-11 Izabela Guimarães Barbosa,Flávia da Mata Chiácchio Leite,Maxime Bertoux,Henrique Cerqueira Guimarães,Luciano Inácio Mariano,Leandro Boson Gambogi,Antônio Lúcio Teixeira,Paulo Caramelli,Leonardo Cruz de Souza
OBJECTIVES Bipolar disorder type 1 (BD1) and behavioral-variant frontotemporal dementia (bvFTD) share similar behavioral and cognitive symptoms, rendering the differential diagnosis between them a clinical challenge. We investigated the accuracy of social cognition (SC) measures to differentiate bvFTD from BD. METHODS We included three groups of participants: early-onset BD1 (in remission, n=20), bvFTD
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Behavioral self-regulation in pediatric bipolar disorder and healthy offspring of bipolar patients. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-01-01 Cristiana C A Rocca,Sheila C Caetano,Gabriel Okawa Belizario,Ana Kleinman,Lena Nabuco de Abreu,Beny Lafer,Geraldo F Busatto,Bernardo C Gomes
OBJECTIVES This study investigated behavioral self-regulation problems using the Children's Hostility Inventory (CHI) in pediatric bipolar disorder (PBD), healthy offspring of bipolar disorder patients (HOBD), and healthy controls (HC) without previous history of psychiatric disorders. METHODS The CHI was administered to 41 consecutive children and adolescents diagnosed with PBD, to 16 HOBD, and to
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Efficacy and safety of ketamine for the treatment of depressive symptoms in palliative care: A systematic review. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-11 Matheus Ghossain Barbosa,Gabriela Takayanagi Garcia,Luciana Maria Sarin,Andrea Parolin Jackowski
OBJECTIVES Ketamine has a fast onset of action that may offer a paradigm change for depression management at the end of life. We aimed to synthesize evidence regarding the safety and efficacy of ketamine in depression treatment within a broad palliative care concept. METHODS We searched seven databases and included studies on the safety and efficacy of ketamine for depression treatment in patients
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Grief, interpersonal disputes and role transitions: the breadth of Interpersonal Telepsychotherapy as a strategy to reduce mental health suffering due to the COVID-19 pandemic in health professionals. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-11 Marcelo Pio Fleck,Lucas Spanemberg,Livia Hartmann de Souza,Giovanni Abrahão Salum Junior
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Naltrexone-induced psychosis in a patient with alcohol use disorder. Brazilian Journal of Psychiatry (IF 5.5) Pub Date : 2023-05-08 Hu Ruei-Yuan,Lee Chuan-Ya