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Exosome-Based Macromolecular neurotherapeutic drug delivery approaches in overcoming the Blood-Brain barrier for treating brain disorders Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-18 Krishna Yadav, R. Vijayalakshmi, Kantrol Kumar Sahu, Pavani Sure, Kavita Chahal, Renu Yadav, Sucheta, Akhilesh Dubey, Megha Jha, Madhulika Pradhan
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Bioequivalence risk assessment of oral formulations containing racemic ibuprofen through a chiral physiologically based pharmacokinetic model of ibuprofen enantiomers Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-17 Javier Reig-López, Marina Cuquerella-Gilabert, Enrique Bandín-Vilar, Matilde Merino-Sanjuán, Víctor Mangas-Sanjuán, Alfredo García-Arieta
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Transcriptomic and western blot characterisation of the human CLEFF4 clone, a new rapid cell line replacement for the Caco2 model Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-17 Andrew Crowe
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Minitablets current use and future opportunities – An APV course on manufacturing, packaging, characterization and use of minitablets Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-16 Susanne Page, Timo Rode, Jörg Breitkreutz, Leonie Wagner-Hattler
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Formulation study of PLGA in situ films for topical delivery of salicylates Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-12 Eva Snejdrova, Jan Loskot, Andrea Veris, Petr Kastner, Rudolf Andrys
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Layer-by-layer self-assembly embedding of nattokinase in chitosan/γ-polyglutamic acid: Preparation, fibrinolytic activity, stability, and in vitro digestion study Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-08 Zhihan Liu, Yan He, Hua Zhang, Xia Ma
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Throat spray formulated with virucidal pharmaceutical excipients as an effective early prophylactic or treatment strategy against pharyngitis post-exposure to SARS-CoV-2 Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-07 Amira A. Boseila, Ahmed Z. Ghareeb, Miral G. AbdElwahab, Mohamed G. Seadawy, Ahmed A. Al-Karmalawy, Nashwa W. Yassa, Doaa A. Ghareeb
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Engineering resveratrol-loaded chitosan nanoparticles for potential use against Helicobacter pylori infection Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-06 Larissa Spósito, Diana Fonseca, Suzana Gonçalves Carvalho, Rafael Miguel Sábio, Gabriel Davi Marena, Taís Maria Bauab, Andréia Bagliotti Meneguin, Paula Parreira, M. Cristina L. Martins, Marlus Chorilli
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Continuous direct compression of a commercially batch-manufactured tablet formulation with two different processing lines Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-05 Jenna Lyytikäinen, Pawel Stasiak, Tomáš Kubelka, Ivan Bogaerts, Adam Wanek, Bart Stynen, James Holman, Jarkko Ketolainen, Tuomas Ervasti, Ossi Korhonen
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Corrigendum to ’Co-assembly of doxorubicin and curcumin targeted micelles for synergistic delivery and improving anti-tumor efficacy’ [Eur. J. Pharma. Biopharm. 112 (2017) 209–223] Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-04 Wenzhuan Ma, Qiang Guo, Ying Li, Xiaohui Wang, Jinling Wang, Pengfei Tu
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Exploring the potential of black cumin derived nanovesicles for miRNA drug delivery Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-04 Adelina Khristiani Rahayu, Azzania Fibriani, Marselina Irasonia Tan
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Is there a fast track (“Darmstrasse”) for fluids in the small intestine? Evidence from magnetic resonance imaging Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-04 Linus Großmann, Katharina Springub, Linda Krüger, Fabian Winter, Adrian Rump, Marie-Luise Kromrey, Robin Bülow, Norbert Hosten, Jennifer Dressman, Werner Weitschies, Michael Grimm
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Can (Natural) deep eutectic systems increase the efficacy of ocular therapeutics? Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-04-04 Célia Sarmento, Ana Rita C. Duarte, Ana Rita Jesus
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Exploring the effect of protein secondary structure on the solid state and physical stability of protein-based amorphous solid dispersions Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-30 Xuezhi Zhuo, Julia Ochner, Donglei Leng, Vito Foderà, Korbinian Löbmann
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Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicity Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-26 J. Anupama Sekar, Shiny Velayudhan, M. Senthilkumar, P.R. Anil Kumar
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Development of a simple paste for 3D printing of drug formulations containing a mesoporous material loaded with a poorly water-soluble drug Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-26 Christos S. Katsiotis, Evgenii Tikhomirov, Christos Leliopoulos, Maria Strømme, Ken Welch
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Exploring the influence of microstructure and phospholipid type of liposomes on their interaction with lung Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-25 Jing Zhao, Ye Yuan, Jingwen Xue, Anyue Hou, Shimeng Song, Jian Guan, Xin Zhang, Shirui Mao
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Sucrose ester embedded lipid carrier for DNA delivery Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-23 Yinan Zhao, Wanting Ma, Kexin Tian, Zhe Wang, Xingxing Fu, Qi Zuo, Yanfei Qi, Shubiao Zhang
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Corrigendum to “Sequentially dynamic polymeric micelles with detachable PEGylation for enhanced chemotherapeutic efficacy” [Eur. J. Pharm. Biopharm. 145 (2019) 54–64] Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-22 Guoqing Yan, Yan Huang, Dapeng Li, Yong Xu, Jun Wang, Xin Wang, Rupei Tang
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Exploring the potential of P-glycoprotein inhibitors in the targeted delivery of anti-cancer drugs: A comprehensive review Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-20 Dhvani Patel, Nutan Sethi, Paresh Patel, Shreeraj Shah, Kaushika Patel
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Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-16 Melike Ongun, Abhijeet Girish Lokras, Saahil Baghel, Zhenning Shi, Signe Tandrup Schmidt, Henrik Franzyk, Thomas Rades, Federica Sebastiani, Aneesh Thakur, Camilla Foged
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Meta-analysis guided development of a standard artificial urine Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-16 Kimberley A. Noble, Hayley K.Y. Chan, Oisín N. Kavanagh
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Don’t shake it! Mechanical stress testing of mRNA-lipid nanoparticles Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-15 Anna Ruppl, Denis Kiesewetter, Franziska Strütt, Monika Köll-Weber, Regine Süss, Andrea Allmendinger
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Reducing hydrophobic drug adsorption in an in-vitro extracorporeal membrane oxygenation model Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-14 Nitish Khurana, Kamiya Watkins, Debika Ghatak, Jane Staples, Oliver Hubbard, Venkata Yellepeddi, Kevin Watt, Hamidreza Ghandehari
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Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Annika Valtari, Susanna Posio, Elisa Toropainen, Anusha Balla, Jooseppi Puranen, Amir Sadeghi, Marika Ruponen, Veli-Pekka Ranta, Kati-Sisko Vellonen, Arto Urtti, Eva M. del Amo
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Phage-Based antibacterial hydrogels for bacterial targeting and Ablation: Progress and perspective Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Haoran Bai, Qinggele Borjihan, Zheng Li, Peiran Qin, Jingli Cheng, Douxin Xiao, Alideertu Dong
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Phototoxicity in vitro and safety in vivo of the emulsion photosensitizer based on furanocoumarins of Heracleum sosnowskyi Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Oleg A. Kulikov, Vasilisa I. Shlyapkina, Ekaterina P. Brodovskaya, Amina M. Al-khadj Aioub, Valentin P. Ageev, Mikhail N. Zharkov, Denis E. Yakobson, Daniil S. Sokushev, Nikolay A. Pyataev, Gleb B. Sukhorukov
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Recent advances of ultrasound-responsive nanosystems in tumor immunotherapy Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Penghui Wang, Ji Chen, Runming Zhong, Yuanyuan Xia, Zhina Wu, Chunye Zhang, Hai Yao
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Synthesis of folate targeted theranostic cubosomal platform for co-delivery of bismuth oxide and doxorubicin to melanoma in vitro and in vivo Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Mahsa Zahiri, Hosein Kamali, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Negar Nekooei, Mohammad Ramezani, Mona Alibolandi
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Cyclodextrin microneedles for the delivery of a nanoparticle-based peptide antigen vaccine Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-11 Silvana Geisshüsler, Frida A. Nilsson, Nicole Ziak, Zuzanna Kotkowska, Marta Paolucci, Marina Green Buzhor, Nicole Zoratto, Pål Johansen, Jean-Christophe Leroux
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Antimicrobial peptide A9K as a gene delivery vector in cancer cells Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-11 Silvia Cirillo, Bo Zhang, Stephen Brown, Xiubo Zhao
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Identification of structural origins of complex charge heterogeneity in therapeutic ACE2Fc fusion protein facilitated by free-flow isoelectric focusing Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-10 Lingyu Wang, Hai Wu, Ting Cao, Hongyang Li, Pengcheng Shen, Lihong Lu, Zhongli Zhang
Fc Fusion protein represents a versatile molecular platform with considerable potential as protein therapeutics of which the charge heterogeneity should be well characterized according to regulatory guidelines. Angiotensin-converting enzyme 2 Fc fusion protein (ACE2Fc) has been investigated as a potential neutralizing agent to various coronaviruses, including the lingering SARS-CoV-2, as this coronavirus
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Effect of in vitro transcription conditions on yield of high quality messenger and self-amplifying RNA Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-09 Petya G. Popova, Melissa A. Lagace, George Tang, Anna K. Blakney
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Toward the boosted loading of cisplatin drug into liposome nanocarriers Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-06 Anna M. Wróblewska, Ewelina Łukawska, Zuzanna Wakuła, Joanna Zajda, Bernhard K. Keppler, Andrei R. Timerbaev, Magdalena Matczuk
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Preparation of etoposide liposomes for enhancing antitumor efficacy on small cell lung cancer and reducing hematotoxicity of drugs Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-06 Ruixue Huang, Huali Chen, Damao Pi, Xuemei He, Chao Yu, Chaoqun Yu
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Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-03 David C. Jürgens, Joschka T. Müller, Anny Nguyen, Olivia M. Merkel
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Development of an in vitro co-culture model using Caco-2 and J774A.1 cells to mimic intestinal inflammation Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-02 Mona Belaid, Jana Javorovic, Giorgia Pastorin, Driton Vllasaliu
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On the uncertainty of the correlation between nanoparticle avidity and biodistribution Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-02 Oliver Zimmer, Achim Goepferich
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Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust molecule: A case study of Aprepitant Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-01 Ajay Sanjay Lale, Arvind Sirvi, Shubham Debaje, Sadhana Patil, Abhay T. Sangamwar
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A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on the tensile strength Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-28 Valentinë Lura, Stefan Klinken, Jörg Breitkreutz
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Development of cationic solid lipid nanoparticles incorporating cholesteryl-9-carboxynonanoate (9CCN) for delivery of antagomiRs to macrophages Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-27 Adrian Mallén, David A. Narváez-Narváez, M.D. Pujol, Estanis Navarro, Josep Maria Suñé-Negre, Encarna García-Montoya, Pilar Pérez-Lozano, Benjamín Torrejón-Escribano, Marc Suñé-Pou, Miguel Hueso
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Minimizing pain in deer antler removal: Local anaesthetics in ZnO nanoparticle based collagen dressings as a promising solution Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-24 Farzin Sahebjam, Paul Chambers, Kavitha Kongara, Yi Zhang, Nicholas Lopez, Antony Jacob, Preet Singh, Sujay Prabakar
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Analytical techniques for the characterization of nanoparticles for mRNA delivery Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-23 Sara S. Nogueira, Eleni Samaridou, Johanna Simon, Simon Frank, Moritz Beck-Broichsitter, Aditi Mehta
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RNA-encapsulating lipid nanoparticles in cancer immunotherapy: From pre-clinical studies to clinical trials Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-23 Tiffaney Hsia, Yunching Chen
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Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6 Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-22 Maximilian Walther, Robert Jenke, Achim Aigner, Alexander Ewe
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Kinetics of RNA-LNP delivery and protein expression Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-20 Judith A. Müller, Nathalie Schäffler, Thomas Kellerer, Gerlinde Schwake, Thomas S. Ligon, Joachim O. Rädler
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Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-20 A. Abruzzo, R. Pucci, P.M. Abruzzo, S. Canaider, C. Parolin, B. Vitali, F. Valle, M. Brucale, T. Cerchiara, B. Luppi, F. Bigucci
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Long acting tariquidar loaded stearic acid-modified hydroxyapatite enhances brain penetration and antitumor effect of temozolomide Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-19 Cheng-Ping Yu, Shang-Wen Lin, Jui-Chen Tsai, Yan-Jye Shyong
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Advancing injection force modeling and viscosity-dependent injectability evaluation for prefilled syringes Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-18 Linke Wu, Hui Li, Yunyun Wang, Chengyu Liu, Zhixin Zhao, Guisheng Zhuang, Quanmin Chen, Weichang Zhou, Jeremy Guo
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Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-17 Camilla Hald Gregersen, Razan Mearraoui, Pia Pernille Søgaard, Gael Clergeaud, Karsten Petersson, Andrew J. Urquhart, Jens B. Simonsen
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Assessing Abuse-Deterrent formulations utilizing Ion-Exchange resin complexation processed via Twin-Screw granulation for improved safety and effectiveness Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-17 Siva Ram Munnangi, Nagarjuna Narala, Preethi Lakkala, Sateesh Kumar Vemula, Michael Repka
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Rapid characterization of physical properties for the pharmaceutical pellet cores based on NIR spectroscopy and ensemble learning Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-15 Sijun Wu, Chaoliang Jia, Li Wang, Cheng Ye, Zheng Li, Wenlong Li
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Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-15 Pieterjan Merckx, Griet Conickx, Evy Blomme, Tania Maes, Ken R. Bracke, Guy Brusselle, Stefaan C. De Smedt, Koen Raemdonck
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Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-15 Tao Yin, Ning Wang, Fang Jia, Yuchao Wu, Lei Gao, Jing Zhang, Rongrong Hou
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Personalised oral dosage forms using an ultra-compact tablet press at the point of care Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-14 Ingo Krause, Rene Manigk, Elena Arribas Lopez, Dennis Douroumis
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Reply to comments by Dr. Ali Shayanfar Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-12 Han Hao, Jing Wang
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Comments on “Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration” Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-12 Raha Kaviani, Amin Alvani, Ali Shayanfar
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The role of phospholipids in drug delivery formulations – Recent advances presented at the Researcher’s Day 2023 Conference of the Phospholipid Research Center Heidelberg Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-11 Richard Wibel, Peter van Hoogevest, Simon Drescher
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Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-10 Viktor Laurin Sedlmayr, Silvia Schobesberger, Sarah Spitz, Peter Ertl, David Johannes Wurm, Julian Quehenberger, Oliver Spadiut
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