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Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation J. Adv. Res. (IF 6.992) Pub Date : 2021-03-04 Heng Li; Xianglei Zhang; Caigui Xiang; Chunlan Feng; Chen Fan; Moting Liu; Huimin Lu; Haixia Su; Yu Zhou; Qing Qi; Yechun Xu; Wei Tang
Arctigenin, derived from Arctium lappa L., has multiple pharmacological activities, including immunoregulatory, anti-diabetic, anti-tumor, and neuroprotective effects. Nevertheless, the potential therapeutic target of arctigenin in modulating inflammation remains undefined. In the present study, we identified that arctigenin was a phosphodiesterase-4 (PDE4) selective inhibitor for the first time. Arctigenin
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The hepatitis D virus in Italy. A vanishing infection, not yet a vanished disease J. Adv. Res. (IF 6.992) Pub Date : 2021-03-02 Gian Paolo Caviglia; Silvia Martini; Alessia Ciancio; Grazia Anna Niro; Antonella Olivero; Rossana Fontana; Francesco Tandoi; Chiara Rosso; Renato Romagnoli; Giorgio Maria Saracco; Antonina Smedile; Mario Rizzetto
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Progesterone affects clinic oocyte yields by coordinating with follicle stimulating hormone via PI3K/AKT and MAPK pathways J. Adv. Res. (IF 6.992) Pub Date : 2021-03-02 Hui Long; Weina Yu; Sha Yu; Mingru Yin; Ling Wu; Qiuju Chen; Renfei Cai; Lun Suo; Li wang; Qifeng Lyu; Yanping Kuang
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Understanding mechanisms of shape memory function deterioration for nitinol alloy during non-equilibrium solidification by electron beam J. Adv. Res. (IF 6.992) Pub Date : 2021-02-25 Guoqing Chen; Junpeng Liu; Zhibo Dong; Yulong Li; Yuxing Zhao; Binggang Zhang; Jian Cao
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Innate Tumor-Targeted Nanozyme Overcoming Tumor Hypoxia for Cancer Theranostic Use J. Adv. Res. (IF 6.992) Pub Date : 2021-02-24 Hanitrarimalala Veroniaina; Zhenghong Wu; Xiaole Qi
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Derivation of “Egyptian Varices Prediction (EVP) Index”: A Novel Noninvasive Index for Diagnosing Esophageal Varices in HCV J. Adv. Res. (IF 6.992) Pub Date : 2021-02-24 Shimaa M. Abd-Elsalam; Mohamed M. Ezz; Shehab Gamalel-Din; Gamal Esmat; Wafaa Elakel; Mahmoud ElHefnawi
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Assessment of the Link of ABCB1 and NR3C1 gene polymorphisms with the prednisolone resistance in pediatric nephrotic syndrome patients of Bangladesh: a genotype and haplotype approach J. Adv. Res. (IF 6.992) Pub Date : 2021-02-17 Most. Nazma Parvin; Md. Abdul Aziz; Sikder Nahidul Islam Rabbi; Mir Md. Abdullah Al-Mamun; Mohammed Hanif; Md. Saiful Islam; Mohammad Safiqul Islam
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The heterogeneity among subgroups of haplogroup J influencing Alzheimer’s disease risk J. Adv. Res. (IF 6.992) Pub Date : 2021-02-17 HaoChen Liu; Yixuan Zhang; Huimin Zhao; Yanan Du; XiaoQuan Liu
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PIK3CB is associated with metastasis through the regulation of cell adhesion to collagen I in pancreatic cancer J. Adv. Res. (IF 6.992) Pub Date : 2021-02-17 Jianhua Qu; Biao Zheng; Kenoki Ohuchida; Haimin Feng; Stephen Jun Fei Chong; Xianbin Zhang; Rui Liang; Zhong Liu; Kengo Shirahane; Kazuhiro Mizumoto; Peng Gong; Masafumi Nakamura
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Erythrina velutina Willd. alkaloids: piecing biosynthesis together from transcriptome analysis and metabolite profiling of seeds and leaves J. Adv. Res. (IF 6.992) Pub Date : 2021-02-10 Daisy Sotero Chacon; Taffarel de Melo Torres; Ivanice Bezerra da Silva; Thiago Ferreira de Araújo; Alan de Araújo Roque; Francisco Ayrton Senna Domingos Pinheiro; Denise Selegatto; Alan Pilon; Fernanda Priscila Santos Reginaldo; Cibele Tesser da Costa; Johnatan Vilasboa; Rafael Freire; Eduardo Luiz Voigt; José Angelo Silveira Zuanazzi; Renata Libonati; Julia A. Rodrigues; Filippe L.M. Santos; Kátia
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CSN improves seed vigor of aged sunflower seeds by regulating fatty acid, glycometabolism, and abscisic acid metabolism J. Adv. Res. (IF 6.992) Pub Date : 2021-02-09 Yutao Huang; Shuyu Cai; Xiaoli Ruan; Jun Xu; Dongdong Cao
Intro duction: Sunflower seeds possess higher oil content than do cereal crop seeds. Storage of sunflower seeds is accompanied by loss of seed vigor and oxidation of storage and membrane lipids. Objectives This study first reported that compound sodium nitrophenolate (CSN), a new plant growth modulator, improved the germination and seedling emergence of aged sunflower seeds. The present study provide
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Based on Tumor Mutation Burden to construct diagnosis and prognosis models and provides guidance for the treatment in the Hepatocellular Carcinoma patients J. Adv. Res. (IF 6.992) Pub Date : 2021-02-09 Bufu Tang; Jinyu Zhu; Zhongwei Zhao; Chenying Lu; Siyu Liu; Shiji Fang; Liyun Zheng; Nannan Zhang; Minjiang Chen; Min Xu; Risheng Yu; Jiansong Ji
Introduction The development and prognosis of HCC involve complex molecular mechanisms, which affect the effectiveness of its treatment strategies. Tumor mutational burden (TMB) is related to the efficacy of immunotherapy, but the prognostic role of TMB-related genes in HCC has not yet been determined clearly. Objectives In this study, we identified TMB-specific genes with good prognostic value to
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Longxuetongluo Capsule protects against cerebral ischemia/reperfusion injury through endoplasmic reticulum stress and MAPK-mediated mechanisms J. Adv. Res. (IF 6.992) Pub Date : 2021-02-09 Bo Pan; Jing Sun; Ziyu Liu; Lingxiao Wang; Huixia Huo; Yunfang Zhao; Pengfei Tu; Wei Xiao; Jiao Zheng; Jun Li
Introduction Longxuetongluo Capsule (LTC) is wildly applied to treat ischemic stroke in clinical practice in China. However, the pharmacological mechanism of LTC on ischemic stroke is still unstated. Objective Our research was designed to study the protective effect of LTC against cerebral ischemia-reperfusion (I/R) injury and reveal the underlying mechanism both in vivo and in vitro. Methods PC12
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Novel diagnostic options for endometriosis - based on the glycome and microbiome J. Adv. Res. (IF 6.992) Pub Date : 2021-02-05 Zsuzsanna Kovács; Louise Glover; Fiona Reidy; John MacSharry; Radka Saldova
Background Endometriosis is a chronic gynaecological disease whose aetiology is still unknown. Despite its prevalence among women of reproductive age, the pathology of the disease has not yet been elucidated and only symptomatic treatment is available. Endometriosis has high latency and diagnostic methods are both limited and invasive. Aim of Review The aim of this review is to summarise minimally
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The diverse roles of TMEM16A Ca2+-activated Cl- channels in inflammation J. Adv. Res. (IF 6.992) Pub Date : 2021-02-04 Weiliang Bai; Mei Liu; Qinghuan Xiao
Background Transmembrane protein 16A (TMEM16A) Ca2+-activated Cl- channels have diverse physiological functions, such as epithelial secretion of Cl- and fluid and sensation of pain. Recent studies have demonstrated that TMEM16A contributes to the pathogenesis of infectious and non-infectious inflammatory diseases. However, the role of TMEM16A in inflammation has not been clearly elucidated. Aim of
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ultifunctional derivatives of pyrimidine-5-carbonitrile and differently substituted carbazoles for doping-free sky-blue OLEDs and luminescent sensors of oxygen J. Adv. Res. (IF 6.992) Pub Date : 2021-02-04 Uliana Tsiko; Oleksandr Bezvikonnyi; Galyna Sych; Rasa Keruckiene; Dmytro Volyniuk; Jurate Simokaitiene; Iryna Danyliv; Yan Danyliv; Audrius Bucinskas; Xiaofeng Tan; Jouzas Vidas Grazulevicius
Introduction Evolution of organic light-emitting diodes (OLEDs) reached the point, which allows to obtain maximum internal quantum efficiency of 100 % partly using heavy-metal-free emitters exhibiting thermally activated delayed fluorescence (TADF). Such emitters are also predictively perfect candidates for new generation of optical sensors since triplet harvesting can be sensitive to different analytes
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Enzyme–polymeric/inorganic metal oxide/hybrid nanoparticle bio-conjugates in the development of therapeutic and biosensing platforms J. Adv. Res. (IF 6.992) Pub Date : 2021-02-04 Suliman Khan; Mohammad Mahdi Nejadi Babadaei; Anwarul Hasan; Zehra Edis; Farnoosh Attar; Rabeea Siddique; Qian Bai; Majid Sharifi; Mojtaba Falahati
Background Because enzymes can control several metabolic pathways and regulate the production of free radicals, their simultaneous use with nanoplatforms showing protective and combinational properties is of great interest in the development of therapeutic nano-based platforms. However, enzyme immobilization on nanomaterials is not straightforward due to the toxic and unpredictable properties of nanoparticles
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Vitamin D/VDR Regulates Peripheral Energy Homeostasis via Central Renin-Angiotensin System J. Adv. Res. (IF 6.992) Pub Date : 2021-02-02 Han Su; Ning Liu; Yalin Zhang; Juan Kong
Background Some epidemiological studies have revealed vitamin D (VD) deficiency is closely linked with the prevalence of obesity, however, the role of VD in energy homeostasis is yet to be investigated, especially in central nervous system. Given that VD negatively regulates renin in adipose tissue, we hypothesized that central VD might play a potential role in energy homeostasis. Methods This study
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Application of M1 Macrophage as a Live Vector in Delivering Nanoparticles for in vivo Photothermal Treatment J. Adv. Res. (IF 6.992) Pub Date : 2021-02-01 Nu-Ri Im; Taeseok Daniel Yang; Kwanjun Park; Jang-Hoon Lee; Jonghwan Lee; Yoon Hyuck Kim; Jae-Seung Lee; Byoungjae Kim; Kwang-Yoon Jung; Youngwoon Choi; Seung-Kuk Baek
Introduction To enhance photothermal treatment (PTT) efficiency, a delivery method that uses cell vector for nanoparticles (NPs) delivery has drawn attention and studied widely in recent years. Objectives In this study, we demonstrated the feasibility of M1 activated macrophage as a live vector for delivering NPs and investigated the effect of NPs loaded M1 stimulated by Lipopolysaccharide on PTT efficiency
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Virulence alterations in Staphylococcus aureus upon treatment with the sub-inhibitory concentrations of antibiotics J. Adv. Res. (IF 6.992) Pub Date : 2021-01-23 Juan Chen; Huyue Zhou; Jingbin Huang; Rong Zhang; Xiancai Rao
Background The treatment of patients with Staphylococcus aureus infections mainly relies on antistaphylococcal regimens that are established with effective antibiotics. In antibiotic therapy or while living in nature, pathogens often face the sub-inhibitory concentrations (sub-MICs) of antibiotics due to drug pharmacokinetics, diffusion barriers, waste emission, resistant organism formation, and farming
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Naringenin ameliorates homocysteine induced endothelial damage via the AMPKα/Sirt1 pathway J. Adv. Res. (IF 6.992) Pub Date : 2021-01-23 Hui Li; Linlin Liu; Zhiwen Cao; Wen Li; Rui Liu; Youwen Chen; Chenxi Li; Yurong Song; Guangzhi Liu; Jinghong Hu; Zhenli Liu; Cheng Lu; Yuanyan Liu
Introduction Endothelial damage (ED) has been implicated in accelerating the development of atherosclerosis. The latter condition is a risk factor for developing several cardiovascular diseases (CVDs) associated with high morbidity and mortality rates worldwide. Objectives In our previous studies, we found naringenin (Nar), a bioactive flavanone compound, to protect against mitochondrial damage and
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Pathological and immunological characterization of bluetongue virus serotype 1 infection in type I interferons blocked immunocompetent adult mice J. Adv. Res. (IF 6.992) Pub Date : 2021-01-20 Mani Saminathan; Karam Pal Singh; Madhulina Maity; Sobharani Vineetha; Gundallhalli Bayyappa Manjunathareddy; Kuldeep Dhama; Yashpal Singh Malik; Muthannan Andavar Ramakrishnan; Jyoti Misri; Vivek Kumar Gupta
Introduction Wild-type adult mice with intact interferon (IFN) system were neither susceptible to bluetongue virus (BTV) infection nor showed signs of morbidity/mortality. Establishment of immunologically competent wild-type adult mouse model with type I IFNs blockade is necessary to assess the pathogenesis, immune responses and testing of BTV vaccines. Objectives Present study aimed to establish and
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The numerical solution of high dimensional variable-order time fractional diffusion equation via the Singular boundary method J. Adv. Res. (IF 6.992) Pub Date : 2021-01-16 Vahid Reza Hosseini; Farzaneh Yousefi; W.-N. Zou
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Lung cancer dynamics using fractional order impedance modeling on a mimicked lung tumor setup J. Adv. Res. (IF 6.992) Pub Date : 2021-01-13 Maria Ghita; Dana Copot; Clara M. Ionescu
Introduction: As pulmonary dysfunctions are prospective factors for developing cancer, efforts are needed to solve the limitations regarding applications in lung cancer. Fractional order respiratory impedance models can be indicative of lung cancer dynamics and tissue heterogeneity. Objective: The purpose of this study is to investigate how the existence of a tumorous tissue in the lung modifies the
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Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria J. Adv. Res. (IF 6.992) Pub Date : 2021-01-12 Engy A. Abdel-Rahman; Salma Hosseiny; Abdullah Aaliya; Mohamed Adel; Basma Yasseen; Abdelrahman Al-Okda; Yasmine Radwan; Saber H. Saber; Nada Elkholy; Eslam Elhanafy; Emily E. Walker; Juan P. Zuniga-Hertz; Hemal H. Patel; Helen R. Griffiths; Sameh S. Ali
Introduction Incidents of myocardial infarction and sudden cardiac arrest vary with time of the day, but the mechanism for this effect is not clear. We hypothesized that diurnal changes in the ability of cardiac mitochondria to control calcium homeostasis dictate vulnerability to cardiovascular events. Objectives Here we investigate mitochondrial calcium dynamics, respiratory function, and reactive
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An Alternative Design Approach for Fractional Order Internal Model Controllers for Time Delay Systems J. Adv. Res. (IF 6.992) Pub Date : 2021-01-12 C.I. Muresan; I. Birs; R. De Keyser
Introdu ction: Fractional Order Internal Model Control (FO-IMC) extends the capabilities of the classical IMC approach into the generalized domain of fractional calculus. When dealing with processes that exhibit time delays, implementation of such controllers in a classical feedback loop requires the approximation of the fractional order terms, as well as of the corresponding time delays. Objectives
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Novel Pathogenic Mutations and Further Evidence for Clinical Relevance of Genes and Variants Causing Hearing Impairment in Tunisian population J. Adv. Res. (IF 6.992) Pub Date : 2021-01-12 Amal Souissi; Mariem Ben Said; Ikhlas Ben Ayed; Ines Elloumi; Amal Bouzid; Mohamed Ali Mosrati; Mehdi Hasnaoui; Malek Belcadhi; Nabil Idriss; Hassen Kamoun; Nourhene Gharbi; Abdullah A. Gibriel; Abdelaziz Tlili; Saber Masmoudi
Introduction Hearing impairment (HI) is characterized by complex genetic heterogeneity. The evolution of next generation sequencing, including targeted enrichment panels, has revolutionized HI diagnosis. Objectives In this study, we investigated genetic causes in 22 individuals with non-GJB2 HI. Methods We customized a HaloplexHS kit to include 30 genes known to be associated with autosomal recessive
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The Airborne Inertially Stabilized Platform Suspend by an Axial-Radial Integrated Active Magnetic Actuator System J. Adv. Res. (IF 6.992) Pub Date : 2021-01-11 Tong Wen; Biao Xiang
Introduction The inertial stabilization platform (ISP) is widely used in the earth observation system to stably track the line of sight of the payload because it could isolate vibrations and angular motions of the aviation platform. Objectives an active magnetic actuator (AMA) system integrating the axial and the radial control is used to levitate the azimuth gimbal to improve attitude stabilization
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MicroRNAs secreted by human embryos could be potential biomarkers for clinical outcomes of assisted reproductive technology J. Adv. Res. (IF 6.992) Pub Date : 2021-01-11 Fang FANG; Zili LI; Jiangyu YU; Yuting LONG; Qian ZHAO; Xiaofang DING; Li WU; Shumin SHAO; Ling ZHANG; Wenpei XIANG
Introduction MicroRNAs (miRNAs) are important regulators of many biological functions, including embryo implantation and development. Recently, it has been reported that miRNAs in biofluids are predictive for physiological and pathological processes. Objectives In this study, we aim to investigate whether the miRNAs secreted by human embryos in culture medium can be used as embryonic biomarkers. Methods
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CAMOUFLAGE STRATEGIES FOR THERAPEUTIC EXOSOMES EVASION FROM PHAGOCYTOSIS J. Adv. Res. (IF 6.992) Pub Date : 2021-01-08 Nicol Parada; Alfonso Romero-Trujillo; Nicolás Georges; Francisca Alcayaga-Miranda
Background Even though exosome-based therapy has been shown to be able to control the progression of different pathologies, the data revealed by pharmacokinetic studies warn of the low residence time of exogenous exosomes in circulation that can hinder the clinical translation of therapeutic exosomes. The macrophages related to the organs of the mononuclear phagocytic system are responsible primarily
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Fractional and fractal processes applied to cryptocurrencies price series J. Adv. Res. (IF 6.992) Pub Date : 2021-01-07 S.A. David; C.M. C. Inacio Jr.; R. Nunes; J.A.T. Machado
Introduction: Cryptocurrencies have been attracting the attention from media, investors, regulators and academia during the last years. In spite of some scepticism in the financial area, cryptocurrencies are a relevant subject of academic research. Objectives: In this paper, several tools are adopted as an instrument that can help market agents and investors to more clearly assess the cryptocurrencies
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Lung but not brain cancer cell malignancy inhibited by commonly used anesthetic propofol during surgery: Implication of reducing cancer recurrence risk J. Adv. Res. (IF 6.992) Pub Date : 2021-01-06 Cong Hu; Masae Iwasaki; Zhigang Liu; Bincheng Wang; Xiaomeng Li; Han Lin; Jun Li; Jia V. Li; Qingquan Lian; Daqing Ma
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Recovery scenario and immunity in COVID-19 disease: a new strategy to predict the potential of reinfection J. Adv. Res. (IF 6.992) Pub Date : 2021-01-05 Zahra Khoshkam; Younes Aftabi; Peter Stenvinkel; B. Paige Lawrence; Mehran Habibi Rezaei; Gaku Ichihara; Sasan Fereidouni
Background The recent ongoing outbreak of coronavirus disease 2019 (COVID-19), still is an unsolved problem with a growing rate of infected cases and mortality worldwide. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is targeting the angiotensin-converting enzyme 2 (ACE2) receptor and mostly causes a respiratory illness. Although acquired and resistance immunity
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Biostimulation and toxicity: the magnitude of the impact of nanomaterials in microorganisms and plants J. Adv. Res. (IF 6.992) Pub Date : 2021-01-05 Antonio Juárez-Maldonado; Gonzalo Tortella; Olga Rubilar; Paola Fincheira; Adalberto Benavides-Mendoza
Background Biostimulation and toxicity constitute the continuous response spectrum of a biological organism against physicochemical or biological factors. Among the environmental agents capable of inducing biostimulation or toxicity are nanomaterials. On the <100 nm scale, nanomaterials impose both physical effects resulting from the corés and coronás surface properties, and chemical effects related
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Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of Thrombin pathway J. Adv. Res. (IF 6.992) Pub Date : 2021-01-05 Mohamed Gamal El-Din Ewees; Mohamed Sadek Abdel-Bakky; Asmaa Mostafa Ahmed Bayoumi; Ali Ahmed Abo-Saif; Waleed Mohammad Altowayan; Khalid Saad Alharbi; Basim Anwar Shehata Messiha
Introduction Cisplatin (CDDP) nephrotoxicity is one of the most significant complications limiting its use in cancer therapy. Objectives This study investigated the pivotal role played by thrombin in CDDP-mediated nephrotoxicity. This work also aimed to clarify the possible preventive effect of Dabigatran (Dab), a direct thrombin inhibitor, on CDDP nephrotoxicity. Methods Animals were grouped as follow;
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A Value-Added Application of Eugenol As Acaricidal Agent: The Mechanism of Action and the Safety Evaluation J. Adv. Res. (IF 6.992) Pub Date : 2020-12-28 Xiao-Fei Shang; Li-Xia Dai; Chen-Jie Yang; Xiao Guo; Ying-Qian Liu; Xiao-Lou Miao; Ji-Yu Zhang
Introduction Eugenol is a major component of essential oils of several plants, it exhibits significant antiparasitic and acaricidal activities, yet its molecular targets remain unknown. Objectives We aimed to systematically investigate the mechanism of action and the potential targets of eugenol against P. cuniculi, and evaluate the safety for laying the theoretical foundation for clinical application
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Domestication affects the composition, diversity, and co-occurrence of the cereal seed microbiota J. Adv. Res. (IF 6.992) Pub Date : 2020-12-17 Yulduzkhon Abdullaeva; Binoy Ambika Manirajan; Bernd Honermeier; Sylvia Schnell; Massimiliano Cardinale
Introduction The seed-associated microbiome has a strong influence on plant ecology, fitness, and productivity. Plant microbiota could be exploited for a more responsible crop management in sustainable agriculture. However, the relationships between seed microbiota and hosts related to the changes from ancestor species to breeded crops still remain poor understood. Objectives Our aim was i) to understand
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Fibroblast growth factor 13 stabilizes microtubules to promote Na+ channel function in nociceptive DRG neurons and modulates inflammatory pain J. Adv. Res. (IF 6.992) Pub Date : 2020-12-17 Qiong Wang; Jing Yang; Handong Wang; Bin Shan; Chengyu Yin; Hang Yu; Xuerou Zhang; Zishan Dong; Yulou Yu; Ran Zhao; Boyi Liu; Hailin Zhang; Chuan Wang
Introduction Fibroblast growth factor homologous factors (FHFs), among other fibroblast growth factors, are increasingly found to be important regulators of ion channel functions. Although FHFs have been link to several neuronal diseases and arrhythmia, its role in inflammatory pain still remains unclear. Objectives This study aimed to investigate the role and mechanism of FGF13 in inflammatory pain
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Preparation of biological sustained-release nanocapsules and explore on algae-killing properties J. Adv. Res. (IF 6.992) Pub Date : 2020-12-15 Jinyun Li; Ming Guo; Yiping Wang; Bihuan Ye; Youwu Chen; Xuejuan Yang
Introduction Green algae seriously affect the quality and yield of Torreya grandis, it is important to explore new, environmentally friendly ways to control it. Objectives The present study aimed at preparing sustained-release algae-killing nanocapsules without pollution to the environment. Methods In this work, sodium carboxymethylcellulose (CMC), sodium alginate (SA), and chitosan (CTS) were used
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Study on Machining Characteristics of Magnetically Controlled Laser Induced Plasma Micro-machining Single-crystal Silicon J. Adv. Res. (IF 6.992) Pub Date : 2020-12-15 Yanming Zhang; Zhen Zhang; Yi Zhang; Denghua Liu; Jie Wu; Yu Huang; Guojun Zhang
Introduction Laser induced plasma micro-machining (LIPMM) has proved its superiority in micro-machining of hard and brittle materials due to less thermal defects, smaller heat affected zone and larger aspect ratio compared to conventional laser ablation. Objectives In order to improve characteristics and stability of induced plasma, this paper proposed magnetically controlled LIPMM (MC-LIPMM) to achieve
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Analysis of fractional model of guava for biological pest control with memory effect J. Adv. Res. (IF 6.992) Pub Date : 2020-12-10 Jagdev Singh; Behzad Ganbari; Devendra Kumar; Dumitru Baleanu
Introduction Fractional operators find their applications in several scientific and engineering processes. We consider a fractional guava fruit model involving a non-local additionally non-singular fractional derivative for the interaction into guava pests and natural enemies. The fractional guava fruit model is considered as a Lotka-Volterra nature. Objectives The main objective this work is to study
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Rare variants discovery by extensive whole-genome sequencing of the Han Chinese population in Taiwan: applications to cardiovascular medicine J. Adv. Res. (IF 6.992) Pub Date : 2020-12-07 Jyh-Ming Jimmy Juang; Tzu-Pin Lu; Ming-Wei Su; Chien-Wei Lin; Jenn-Hwai Yang; Hou-Wei Chu; Chien-Hsiun Chen; Yi-Wen Hsiao; Chien-Yueh Lee; Li-Mei Chiang; Qi-You Yu; Chuh-Hsing K. Hsiao; Ching-Yu Julius Chen; Pei-Ei Wu; Chien-Hua Pai; Eric Y. Chuang; Chen-Yang Shen
Introduction A population-specific genomic reference is important for research and clinical practice, yet it remains unavailable for Han Chinese (HC) in Taiwan. Objectives We report the first whole genome sequencing (WGS) database of HC (1000 Taiwanese genome (1KTW-WGS)) and demonstrate several applications to cardiovascular medicine. Methods Whole genomes of 997 HC were sequenced to at least 30X depth
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Comprehensive analysis of the lysine acetylome and succinylome in the hippocampus of gut microbiota-dysbiosis mice J. Adv. Res. (IF 6.992) Pub Date : 2020-12-07 Lanxiang Liu; Haiyang Wang; Xuechen Rao; Ying Yu; Wenxia Li; Peng Zheng; Libo Zhao; Chanjuan Zhou; Juncai Pu; Deyu Yang; Liang Fang; Ping Ji; Jinlin Song; Hong Wei; Peng Xie
Introduction Major depressive disorder is caused by gene–environment interactions, and the host microbiome has been recognized as an important environmental factor. However, the underlying mechanisms of the host–microbiota interactions that lead to depression are complex and remain poorly understood. Objectives The present study aimed to explore the possible mechanisms underlying gut microbiota dysbiosis-induced
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Magnetic nanocatalysts as multifunctional platforms in cancer therapy through the synthesis of anticancer drugs and facilitated Fenton reaction J. Adv. Res. (IF 6.992) Pub Date : 2020-12-05 Suliman Khan; Majid Sharifi; Anwarul Hasan; Farnoosh Attar; Zehra Edis; Qian Bai; Hossein Derakhshankhah; Mojtaba Falahati
Background Heterocyclic compounds have always been used as a core portion in the development of anticancer drugs. However, there is a pressing need for developing inexpensive and simple alternatives to high-cost and complex chemical agents-based catalysts for large-scale production of heterocyclic compounds. Also, development of some smart platforms for cancer treatment based on nanoparticles (NPs)
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Dynamics of fractional order nonlinear System: A realistic perception with Neutrosophic Fuzzy number and Allee Effect J. Adv. Res. (IF 6.992) Pub Date : 2020-12-03 Najeeb Alam Khan; Oyoon Abdul Razzaq; Fatima Riaz; Ali Ahmadian; Norazak Senu
Introduction The fusion of fractional order differential equations and fuzzy numbers has been widely used in modelling different engineering and applied sciences problems. In addition to these, the Allee effect, which is of high importance in field of biology and ecology, has also shown great contribution among other fields of sciences to study the correlation between density and the mean fitness of
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Optimal Charging of Fractional-order Circuits with Cuckoo Search J. Adv. Res. (IF 6.992) Pub Date : 2020-12-03 A.M. AbdelAty; Mohammed E. Fouda; Menna T.M.M. Elbarawy; A.G. Radwan
Introduction: Optimal charging of RC circuits is a well-studied problem in the integer-order domain due to its importance from economic and system temperature hazards perspectives. However, the fractional-order counterpart of this problem requires investigation. Objectives: This study aims to find approximate solutions of the most energy-efficient input charging function in fractional-order RC circuits
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Micro-RNAs in the regulation of immune response against SARS COV-2 and other viral infections J. Adv. Res. (IF 6.992) Pub Date : 2020-12-02 Tareq Abu-Izneid; Noora AlHajri; Abdallah Mohammed Ibrahim; Md. Noushad Javed; Khairi Mustafa Salem; Faheem Hyder Pottoo; Mohammad Amjad Kamal
Background Micro-RNAs (miRNAS) are non-coding, small RNAs that have essential roles in different biological processes through silencing genes, they consist of 18-24 nucleotide length RNA molecules. Recently, miRNAs have been viewed as important modulators of viral infections they can function as suppressors of gene expression by targeting cellular or viral RNAs during infection. Aim of Review We describe
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Genomic characterization of SARS-CoV-2 in Egypt J. Adv. Res. (IF 6.992) Pub Date : 2020-11-26 Abdel-Rahman N. Zekri; Khaled Easa Amer; Mohammed M Hafez; Zeinab K. Hassan; Ola S Ahmed; Hany K. Soliman; Abeer A. Bahnasy; Wael Abdel Hamid; Ahmad Gad; Mahmoud Ali; Wael Hassan; Mahmoud Samir; Ahmad Raouf; Ayman A. Khattab; Mona Salah El Din Hamdy; May Sherif Soliman; Maha Hamdi El Sissy; Sara Mohamed El khateeb; Mohamed Abouelhoda
Introduction The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the globe, causing a pandemic. In Egypt over 96,108 individuals were infected so far. Objective In the present study, the objective is to perform a complete genome sequence of SAR-CoV2 isolated from Egyptian coronavirus disease (COVID-19) patients. Methods Nasopharyngeal swabs were
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Robotic in situ 3D bio-printing technology for repairing large segmental bone defects J. Adv. Res. (IF 6.992) Pub Date : 2020-11-25 Lan Li; Jianping Shi; Kaiwei Ma; Jing Jin; Peng Wang; Huixin Liang; Yi Cao; Xingsong Wang; Qing Jiang
Introduction The traditional clinical treatment of long segmental bone defects usually requires multiple operations and depends on donor availability. The 3D bio-printing technology constitutes a great potential therapeutic tool for such an injury. However, in situ 3D bio-printing remains a major challenge. Objectives In this study, we report the repair of long segmental bone defects by in situ 3D
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Synthesis, microstructural characterization and nanoindentation of Zr, Zr-nitride and Zr-carbonitride coatings deposited using magnetron sputtering J. Adv. Res. (IF 6.992) Pub Date : 2020-11-25 Anwar Ul-Hamid
Introduction Hard coatings are primarily based on carbides, nitrides and carbonitrides of transition metal elements such as W, Ti, Zr, etc. Zr-based hard coatings show good resistance to wear, erosion, and corrosion as well as exhibit high hardness, high temperature stability, and biocompatibility, making them suitable candidates for tribological, biomedical, and electrical applications. Objectives
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RBC-derived vesicles as a systemic delivery system of doxorubicin for lysosomal-mitochondrial axis-improved cancer therapy J. Adv. Res. (IF 6.992) Pub Date : 2020-11-24 Shu-Hui Wu; Chia-Chu Hsieh; Szu-Chun Hsu; Ming Yao; Jong-Kai Hsiao; Shih-Wei Wang; Chih-Peng Lin; Dong-Ming Huang
Introd uction Chemotherapeutic drugs are the main intervention for cancer management, but many drawbacks impede their clinical applications. Nanoparticles as drug delivery systems (DDSs) offer much promise to solve these limitations. Objectives A novel nanocarrier composed of red blood cell (RBC)-derived vesicles (RDVs) surface-linked with doxorubicin (Dox) using glutaraldehyde (glu) to form Dox-gluRDVs
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PAP90, a novel rice protein plays a critical role in regulation of D1 protein stability of PSII J. Adv. Res. (IF 6.992) Pub Date : 2020-11-23 M. Raghurami Reddy; Satendra K. Mangrauthia; S. Venkata Reddy; P. Manimaran; Poli Yugandhar; P. Naresh Babu; T. Vishnukiran; D. Subrahmanyam; R.M. Sundaram; S.M. Balachandran
Photosystem II (PSII) protein complex plays an essential role in the entire photosynthesis process. Various protein factors are involved in the dynamics of the PSII complex. Here, we report the development and characterization of a loss-of-function mutant pap90 (PSII auxiliary protein- ∼90KDa; OsPAP90) from rice. The mutant showed reduced photosynthesis due to D1 protein instability that subsequently
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Genomics-guided identification of a conserved CptBA-like toxin-antitoxin system in Acinetobacter baumannii J. Adv. Res. (IF 6.992) Pub Date : 2020-11-23 Shahira A. ElBanna; Nayera A. Moneib; Ramy K. Aziz; Reham Samir
Introduction Toxin-antitoxin (TA) systems are widespread among bacteria, archaea and fungi. They are classified into six types (I-VI) and have recently been proposed as novel drug targets. Objectives This study aimed to screen the pathogen Acinetobacter baumannii, known for its alarming antimicrobial resistance, for TA systems and identified a CptBA-like type IV TA, one of the least characterized systems
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Influence of ageing treatment temperature and duration on σ-phase precipitation and mechanical properties of UNS S32750 SDSS alloy J. Adv. Res. (IF 6.992) Pub Date : 2020-11-14 Elisabeta Mirela Cojocaru; Doina Raducanu; Anna Nocivin; Vasile Danut Cojocaru
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A risk prediction model of gene signatures in ovarian cancer through bagging of GA-XGBoost models J. Adv. Res. (IF 6.992) Pub Date : 2020-11-11 Yi-Wen Hsiao; Chun-Liang Tao; Eric Y. Chuang; Tzu-Pin Lu
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Piperidine based 1,2,3-triazolylacetamide derivatives induce cell cycle arrest and apoptotic cell death in Candida auris J. Adv. Res. (IF 6.992) Pub Date : 2020-11-10 Vartika Srivastava; Mohmmad Younus Wani; Abdullah Saad Al-Bogami; Aijaz Ahmad
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Roles of specialized metabolites in biological function and environmental adaptability of tea plant (Camellia sinensis) as a metabolite studying model J. Adv. Res. (IF 6.992) Pub Date : 2020-11-09 Lanting Zeng; Xiaochen Zhou; Yinyin Liao; Ziyin Yang
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33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways J. Adv. Res. (IF 6.992) Pub Date : 2020-11-08 Chunmei Guo; Nannan Li; Chengyong Dong; Liming Wang; Zhaopeng Li; Qinlong Liu; Qinglai Ma; Frederick T. Greenaway; Yuxiang Tian; Lihong Hao; Shuqing Liu; Ming-Zhong Sun
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Comparison of Tear Proteomic and Neuromediator Profiles Changes Between Small Incision Lenticule Extraction (SMILE) and Femtosecond Laser-Assisted in-situ Keratomileusis (LASIK) J. Adv. Res. (IF 6.992) Pub Date : 2020-11-05 Yu-Chi Liu; Gary Hin-Fai Yam; Molly Tzu-Yu Lin; Ericia Teo; Siew-Kwan Koh; Lu Deng; Lei Zhou; Louis Tong; Jodhbir S. Mehta
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Rescuing Key Native Traits in Cultured Dermal Papilla Cells for Human Hair Regeneration J. Adv. Res. (IF 6.992) Pub Date : 2020-11-04 Carla M. Abreu; Mariana T. Cerqueira; Rogério P. Pirraco; Luca Gasperini; Rui L. Reis; Alexandra P. Marques
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