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Cardiovascular disrupting effects of bisphenols, phthalates, and parabens related to endothelial dysfunction: Review of toxicological and pharmacological mechanisms Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-28 Cristina Lemini, Patricia Silveyra, Mariana Segovia-Mendoza
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. CVDs are promoted by the accumulation of lipids and immune cells in the endothelial space resulting in endothelial dysfunction. Endothelial cells are important components of the vascular endothelium, that regulate the vascular flow. The imbalance in the production of vasoactive substances results in the loss of vascular homeostasis
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Effect of beta-cypermethrin on the reproductive capacity of female mice in advanced age Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-28 Qian-Feng Qiao, Li-Qing Wang, De-E. Yu, Na Li, Qiong-Jun Xu, Yong-Jiang Zhou
The aim of the present study was to investigate whether exposure to pesticides beta-cypermethrin (β-CYP) harms the reproductive capacity of advanced-age female mice. The results evidenced that peri-implantation β-CYP exposure significantly reduced the number of fetuses per advanced-age female in the first litter, and the number and weight of implantation sites. The levels of decidualization markers
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Decreased immune response in undernourished rats after air pollution exposure Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-24 Melisa Lidia Kurtz, Nadia Soledad Orona, Christian Lezón, Verónica Cecilia Defosse, Francisco Astort, Guillermo Alberto Maglione, Patricia Mónica Boyer, Deborah Ruth Tasat
Children are highly vulnerable subpopulation to malnutrition and air pollution. We investigate, in a rat nutritional growth retardation (NGR) model, the impact of Residual Oil Fly Ash (ROFA) on the lung immune response using and methods. : Alveolar macrophages (AM) were isolated from Control (C) and NGR animals, cultured and treated with ROFA (1–100 µg/ml) for 24 h. : C and NGR rats were intranasally
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Chronic arsenic exposure suppresses proteasomal and autophagic protein degradation Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Isabell I. Augenstein, Alexandra N. Nail, Ana P. Ferragut Cardoso, J. Christopher States, Mayukh Banerjee
Ubiquitin Proteasomal System (UPS) and autophagy dysregulation initiate cancer. These pathways are regulated by zinc finger proteins. Trivalent inorganic arsenic (iAs) displaces zinc from zinc finger proteins disrupting functions of important cellular proteins. The effect of chronic environmental iAs exposure (100 nM) on UPS has not been studied. We tested the hypothesis that environmental iAs exposure
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Protection against β-N-methylamino-l-alanineꟷinduced vesicular monoamine transporter 2 inhibition by hydroxyl-containing proteinogenic amino acids Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Rianita van Onselen, Chanté Kennedy, Tim G. Downing
β--methylamino--alanine (BMAA) has been shown to inhibit vesicular monoamine transporter 2 (VMAT2), thereby preventing the uptake of monoaminergic neurotransmitters into platelet dense granules and synaptic vesicles. The inhibition is hypothesized to be through direct association of BMAA with hydroxyl groupꟷcontaining amino acid residues in VMAT2. This study evaluated whether BMAA-induced inhibition
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Short-term effects of sodium arsenite (AsIII) and sodium arsenate (AsV) on carbohydrate metabolism in the perfused rat liver Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-23 Nairana Mithieli de Queiroz Eskuarek Melo, Jurandir Fernando Comar, Anacharis Babeto de Sá-Nakanishi, Rosane Marina Peralta, Lívia Bracht, Adelar Bracht
The actions of arsenite and arsenate on carbohydrate metabolism in the once-through perfused rat liver were investigated. The compound inhibited lactate gluconeogenesis with an IC of 25 µM. It also increased glycolysis and fructolysis at concentrations between 10 and 100 µM. This effect was paralleled by strong inhibition of pyruvate carboxylation (IC = 4.25 µM) and by a relatively moderate diminution
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Lead induced genotoxicity and hepatotoxicity in zebrafish (Danio rerio) at environmentally relevant concentration: Nrf2-Keap1 regulated stress response and expression of biomarker genes Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-22 Koushik Kumar Dey, Sreejata Kamila, Tanmoy Das, Ansuman Chattopadhyay
Genotoxic and hepatotoxic potentials of Pb at an environmentally relevant concentration (5 ppm) in zebrafish were investigated in the present study. Erythrocytic nuclear abnormality tests revealed the increased frequencies of abnormal erythrocytes after Pb exposure, indicating a strong genotoxic potential of Pb. Multiple stress-related parameters were further evaluated in liver, the major detoxifying
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Metal bioaccumulation and histological alterations in Oreochromis andersonii at Itezhi-tezhi Dam downstream of a mining area in the Central Province of Zambia Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-19 Chris Sihoka, Ina Wagenaar, Cobus van Dyk
The Itezhi-tezhi Dam on the Kafue River in Zambia is a major capture fishery. However, the upstream reaches of the Kafue River receive effluents from copper mines. It was unclear whether fish health in the dam is adversely affected due to the mining effluents. We investigated the health status of fish in Itezhi-tezh Dam using a histology-based fish health assessment protocol with as a bioindicator
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E-cigarettes exacerbate allergic inflammation via cytokine induction and MUC5AC/5B expression in a murine asthma model Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-19 Young-Ha Lee, Hyung Gyun Na, Yoon Seok Choi, Chang Hoon Bae, Si-Youn Song, Yong-Dae Kim
The effects of electronic cigarettes (e-cigarettes) vapor on inflammation and mucin secretion on asthmatics remain insufficiently explored. This study investigated the effects of e-cigarette vapor on allergic inflammation, cytokine production, and MUC5AC/5B expression in murine asthma model. Airway hyperresponsiveness was significantly higher in the e-cigarette-exposed ovalbumin (OVA) sensitization
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Genotoxicity responses of single and mixed exposure to heavy metals (cadmium, silver, and copper) as environmental pollutants in Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-16 Eşref Demir, Fatma Turna Demir
Heavy metals are now persistently present in living things' environments, in addition to their potential toxicity. Therefore, the aim of this study was to utilize . to determine the biological effects induced by different heavy metals including cadmium chloride (CdCl), copper (II) sulfate pentahydrate (CuSO 4.5 HO), and silver nitrate (AgNO). experiments were conducted utilizing three low and environmentally
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Impact of DEHP Exposure on Female Reproductive Health: Insights into Uterine Effects Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-16 Martínez-Ibarra Alejandra, Marco Cerbón, Martínez-Razo Luis Daniel, Morales-Pacheco Miguel, S Kawa, Rodríguez-Dorantes Mauricio
Several endocrine disrupting compounds released from plastics, including polyfluoroalkyl substances, bisphenols, flame retardants, phthalates and others, are of great concern to human health due to their high toxicity. This review discusses the effects of di-(2-ethylhexyl) phthalate (DEHP), the most common member of the phthalate family, on female reproduction. and studies link DEHP exposure to impaired
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PM2.5 induces cardiac defects via AHR-SIRT1-PGC-1α mediated mitochondrial damage Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-15 Jin Chen, Mingxuan Zhang, Stanley Aniagu, Yan Jiang, Tao Chen
Recent evidence indicates that PM poses a risk for congenital heart diseases but the mechanisms remain unclear. We hypothesized that AHR activated by PM might cause mitochondrial damage via PGC-1α dysregulation, leading to heart defects. We initially discovered that the PGC-1α activator ZLN005 counteracted cardiac defects in zebrafish larvae exposed to EOM (extractable organic matter) from PM. Moreover
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Butyl Benzyl Phthalate (BBP) disrupts neuromast development in embryonic zebrafish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-15 Evelyn Paquette, John Paul Giacalone, Michael Fumo, Nicole M. Roy
Butyl benzyl phthalate (BBP) is found in common household and industrial products world-wide. Phthalates are not covalently bound to plastics and continuously leach into the soil, sediment and aquatic environments. The lateral line system of fish is a mechanosensory system composed of neuromasts essential for survival behaviors including rheotaxis, schooling and predator avoidance. Here, we investigated
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Histological Evidence of Hypothyroidism in Mice Chronically Exposed to Conventional Farming (Revised) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-14 Nádia Coelho, Ricardo Camarinho, Patrícia Garcia, Armindo S Rodrigues
Worldwide, disorders of the thyroid gland are a growing concern; such can be caused by exposure to contaminants, including agrochemicals used in conventional agriculture, which act as endocrine disruptors. The purpose of this study is to evaluate whether or not exposure to an environment with conventional agriculture leads to thyroid disruption. were used as bioindicator species, captured in two sites:
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Depletion kinetics of semicarbazide in giant river prawn (Macrobrachium rosenbergii) following nitrofurazone oral administration and its occurrence in an aquaculture farm Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-13 Putsucha Phansawat, Niti Chuchird, Arunothai Keetanon, Natnicha Chongprachavat, Phongchate Pichitkul, Natthapong Paankhao, Suwinai Paankhao, Lalitphan Kitsanayanyong, Puttharat Baoprasertkul, Tirawat Rairat
Semicarbazide (SEM), a marker residue used to monitor the use of prohibited drug nitrofurazone (NFZ), is commonly found in wild crustaceans, implying the natural origin. However, the difference between endogenous and exogenous SEM has rarely been investigated. So, tissue-bound SEM was determined in samples collected from giant river prawns cultured in an aquaculture farm and in samples from an experiment
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Chronic exposure to 2,2′-azobis-2-amidinopropane that induces intestinal damage and oxidative stress in larvae of Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-13 Rener Mateus Francisco Duarte, Serena Mares Malta, Fernanda Naves Araújo do Prado Mascarenhas, Vinicius Prado Bittar, Ana Luiza Borges, Renata Roland Teixeira, Renata Graciele Zanon, Carlos Ueira Vieira, Foued Salmen Espindola
Embryonic development is exceptionally susceptible to pathogenic, chemistry and mechanical stressors as they can disrupt homeostasis, causing damage and impacted viability. Oxidative stress has the capacity to induce alterations and reshape the environment. However, the specific impacts of these oxidative stress-induced damages in the gastrointestinal tract of larvae have been minimally explored. This
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A Model Naphthenic Acid Decouples Oxidative Phosphorylation through Selective Inhibition of Mitochondrial Complex Activity Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-09 Zahra Kalvani, Collins Kamunde, Don Stevens, Michael R. van den Heuvel
The naphthenic acid fraction compound (NAFC), 3,5-dimethyladamantane-1-acetic acid, was tested for its ability to uncouple mitochondrial oxidative phosphorylation. Mitochondria isolated from rainbow trout () liver were exposed to 3,5-dimethyladamantane-1-acetic acid in state 3 and 4 respiration and mitochondrial membrane potential were quantified. Electron transport chain (ETC) protein complexes were
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Oxidative stress-activated Nrf2 remitted polystyrene nanoplastic-induced mitochondrial damage and inflammatory response in HepG2 cells Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-08 Menghao Guo, Yunjing Li, Shuyan Niu, Rui Zhang, Xin Shen, Yu Ma, Liqing Wu, Tianshu Wu, Ting Zhang, Meng Tang, Yuying Xue
Generated from plastics, microplastics (MPs) and nanoplastics (NPs) are difficult to completely degrade in the natural environment, which can accumulate in almost all lives. Liver is one of the main target organs. In this study, HepG2 and L02 cells were exposed to 0-50μg/mL polystyrene (PS)-NPs to investigate the mechanism of mitochondrial damage and inflammation. The results showed mitochondria damage
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Evaluating the persistence of malachite green residues in tilapia and pacu fish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-06 Lucas Victor Pereira de Freitas, Juliana Grell Fernandes Silveira, Marina Alves Damaceno, Sarah Chagas Campanharo, Agnaldo Fernando Baldo da Silva, da Silva Jonas Joaquim Mangabeira, Ana Carolina Vellosa Portela, Raphael Barbetta de Jesus, James Jacob Sasanya, Fabiana Pilarski, Susanne Rath, Jonas Augusto Rizzato Paschoal
Although banned in food-producing animals, residues of malachite green (MG) and its primary metabolite, leucomalachite green (LMG), have been found in fish due to illegal use in aquaculture and the release of industrial wastewater, which represent a serious risk to food and environmental securities. This study aimed to investigate the residue depletion profile of MG and LMG in edible tissues of Nile
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Are the new phthalates safe? Evaluation of Diisononilphtalate (DINP) effects in porcine ovarian cell cultures Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-06 G. Basini, S. Bussolati, S. Grolli, P. Berni, F. Grasselli
Phthalates are plasticizing chemicals, widely used in packaging materials and consumer products for several decades. These molecules have raised concerns because of their toxicity and their use have been restricted in several countries. Therefore, novel phthalates have been introduced. Among these, diisononilphtalate (DINP) is widely employed. However, its safety has not been properly addressed. Therefore
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Adverse effects of 2,4-D dimethylammonium based-herbicide on Acetylcholinesterase expression in Nile tilapia (Oreochromis niloticus) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-05 Chutima Thanomsit, Prang Khanchanasal, Witchuda Prasatkaew, Jakkaphun Nanuam, Panomsak Meemon, Amnuay Wattanakornsiri, Phochit Nanthanawat
In this study, the evaluation of a 2,4-D dimethylammonium based-herbicide impacted on Nile tilapia was done. The effects focus on Acetylcholinesterase (AChE) expression in the brain, gill, muscle, and plasma using antibody techniques. Our findings revealed a decrease in AChE expression with prolonged exposure. For these, AChE was purified using hydroxyapatite column chromatography. Moreover, the isolated
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Long-term impacts of endocrine-disrupting chemicals exposure on kidney function: A community-based cohort study Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-02 Chun-Yu Chen, Chin-Chan Lee, Heng-Jung Hsu, I-Wen Wu, Yung-Chang Chen, Heng-Chih Pan, Yih-Ting Chen, Cheng-Kai Hsu, Chiao-Yin Sun
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Neurotoxicity of glyphosate: Focus on molecular mechanisms probably associated with alterations in cognition and behavior Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-02 Jesús Chávez-Reyes, Cristian D. Gutiérrez-Reyes, Eduardo Hernández-Cuellar, Bruno A. Marichal-Cancino
In recent decades, glyphosate (Gly) and glyphosate-based herbicides (GBH) have been extensively used in agriculture all over the world. Initially, they were considered safe, but rising evidence suggests that these molecules reach the central nervous system producing metabolic, functional, and permanent alterations that impact cognition and behavior. This theoretical and non-systematic review involved
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Modeling mixtures interactions in environmental toxicology Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-02-02 James Y. Liu, Christie M. Sayes
In the environment, organisms are exposed to mixtures of different toxicants, which may interact in ways that are difficult to predict when only considering each component individually. Adapting and expanding tools from pharmacology, the toxicology field uses analytical, graphical, and computational methods to identify and quantify interactions in multi-component mixtures. The two general frameworks
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Cytotoxicity of vanadium dioxide nanoparticles to human embryonic kidney cell line: Compared with vanadium(IV/V) ions Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-29 Jia-Bei Li, Dan Li, Yuan-Yuan Liu, Aoneng Cao, Haifang Wang
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Modulation in growth, oxidative stress, photosynthesis, and morphology reveals higher toxicity of alpha-cypermethrin than chlorpyrifos towards a non-target green alga at high doses Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-24 Prithu Baruah, Akanksha Srivastava, Yogesh Mishra, Neha Chaurasia
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Polystyrene microplastics effects on zebrafish embryological development: Comparison of two different sizes Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-19 Alessandra La Pietra, Gianluca Fasciolo, Daniela Lucariello, Chiara Maria Motta, Paola Venditti, Ida Ferrandino
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Physiological responses of oxidative damage, genotoxicity and hematological parameters of the toxic effect of neonicotinoid-thiamethoxam in Oreochromis niloticus Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-23 Özge Temiz, Dicle Kargın
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Hepatocellular degeneration in mice co-exposed to in-utero aluminium and cadmium: Implication of a disordered antioxidant and energy homeostatic response in the liver Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-21 Omamuyovwi Irerhievwie, Patrick Chukwuyenum Ichipi-Ifukor, Samuel Ogheneovo Asagba
The current study comprised four groups of pregnant animals viz; Control (CTR) received 10 ml/kg of normal saline, Al:10 mg/kg of AlCl3, Cd: 1.5 mg/Kg of CdCl2 Al+Cd; 10 mg/kg of AlCl3 and 1.5 mg/Kg of CdCl2. Treatment was done from pregnancy days (PNT) 7–20. After delivery, male animals were weaned on PSD 21 and sacrificed on PSD 78. From the study significant increases on serum liver enzymes in the
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Investigation of the effects of crocin on inflammation, oxidative stress, apoptosis, NF-κB, TLR-4 and Nrf-2/HO-1 pathways in gentamicin-induced nephrotoxicity in rats Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-19 Tuba Dogan, Betul Apaydin Yildirim, Kubra Asena Terim Kapakin
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Erythrocyte alterations in specimens of Danio rerio caused by exposure to metformin Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-18 Pablo Americo Barbieri, Luara Lupepsa, Brennda Ribeiro Paupitz, Camila Oliveira de Andrade, Adriana Aparecida Sinópolis Gigliolli, Ana Luiza de Brito Portela-Castro, Ricardo Pereira Ribeiro, Carlos Alexandre Fernandes, Luciana Andreia Borin-Carvalho
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Amitriptyline ecotoxicity in Danio rerio (Hamilton, 1822) embryos – similar toxicity profile in the presence of nanoplastics Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-18 Joana Santos, Angela Barreto, Teresa Coelho, Edna Carvalho, Diogo Pereira, Vânia Calisto, Vera L. Maria
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Assessment of thimerosal effects in sublethal concentrations on zebrafish (Danio rerio) embryos exploring NMR-based metabolomics profile Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-09 Edmilson Rodrigues da Rocha Junior, Viviane Amaral Porto, Alessandre Carmo Crispim, Jeferson Santana Ursulino, Lázaro Wender Oliveira de Jesus, Edson de Souza Bento, Josué Carinhanha Caldas Santos, Thiago Mendonça de Aquino
Thimerosal, a preservative commonly used in the pharmaceutical and cosmetic industry, has raised concerns regarding its potentially toxic effects as an organic mercury compound. Within this context, using an NMR-based metabolomics profile and chemometric analysis, zebrafish embryos were used as an in vivo model to study the effects of thimerosal in metabolic profiles after exposure to sublethal concentrations
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Haematological, biochemical, enzymological changes and mitochondrial dysfunction of liver in freshwater climbing perch Anabas testudineus during their acute and chronic exposure to sodium fluoride Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-01-02 Nimai Chandra Saha, Priyajit Banerjee, Arnab Chatterjee, Ritwick Bhattacharya, Shubhajit Saha, Paolo Pastorino
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Ruminal ergovaline and volatile fatty acid dynamics: Association with poor performance and a key growth regulator in steers grazing toxic tall fescue Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-25 I.M. Llada, R.S. Mote, N.S. Hill, J.M. Lourenco, D.P. Jones, G. Suen, M.K. Ross, N.M. Filipov
Fescue toxicosis (FT) is produced by an ergot alkaloid (i.e., ergovaline [EV])-producing fungus residing in toxic fescue plants. Associations between EV, decreased weight gain and ruminal volatile fatty acids are unclear. Feces, rumen fluid, and blood were collected from 12 steers that grazed non-toxic (NT) or toxic (E +) fescue for 28 days. The E + group exhibited decreased propionate (P), increased
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Fluoxetine may interfere with learning in fish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-27 Malgorzata Grzesiuk, Marta Grabska, Alicja Pawelec
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Pharmacokinetic model of human exposure to ciprofloxacin through consumption of fish Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-30 Oguz Kaan Kum, Karen M. Chan, Noam Morningstar-Kywi, J. Andrew MacKay, Ian S. Haworth
Fluoroquinolones are broad-spectrum antibiotics that accumulate in the environment. To assess human exposure through the food chain, we developed a pharmacokinetic model of fluoroquinolone accumulation in fish and a human pharmacokinetic model to predict gastrointestinal concentrations of ciprofloxacin, a common fluoroquinolone, following consumption of fish. At 70 ng/L ciprofloxacin, the average in
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The use of a complex tetra-culture alveolar model to study the biological effects induced by gold nanoparticles with different physicochemical properties Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-30 Melissa Saibene, Tommaso Serchi, Patrizia Bonfanti, Anita Colombo, Inge Nelissen, Rashi Halder, Jean-Nicolas Audinot, Beatriz Pelaz, Mahmoud G. Soliman, Wolfgang J. Parak, Paride Mantecca, Arno C. Gutleb, Sebastien Cambier
A substantial increase in engineered nanoparticles in consumer products has been observed, heightening human and environmental exposure. Inhalation represents the primary route of human exposure, necessitating a focus on lung toxicity studies. However, to avoid ethical concerns the use of in vitro models is an efficient alternative to in vivo models. This study utilized an in vitro human alveolar barrier
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Indicators of occupational pesticide exposure are associated with psychiatric symptoms. Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-27 Zheng Ruirui, Romero-del Rey Raúl, Garcia-Gonzalez Jessica, Requena-Mullor Mar, Ángela Navarro-Mena, Antonia López-Villén, Alarcon-Rodriguez Raquel
In southeastern Spain, intensive and highly productive agriculture under plastic also poses a risk to human health, as evidenced by reports on acute pesticide poisoning and its effects on mental health. However, knowledge of chronic exposures and their relationship to psychiatric disorders is still limited. This study analyzed the relationship between occupational exposure to pesticides and psychiatric
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A review on fluoride contamination in groundwater and human health implications and its remediation: A sustainable approaches Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-28 Pankaj Kumar, Manoj Kumar, Abdulwasa Bakr Barnawi, Parul Maurya, Snigdha Singh, Deepankshi Shah, Virendra Kumar Yadav, Anand Kumar, Ramesh Kumar, Krishna Kumar Yadav, Amel Gacem, Akil Ahmad, Ashish Patel, Maha Awjan Alreshidi, Vipin Singh, Zaher Mundher Yaseen, Marina M.S. Cabral-Pinto, Vandana Vinayak, Shivraj Gangadhar Wanale
Contamination of drinking water due to fluoride (F−) is a major concern worldwide. Although fluoride is an essential trace element required for humans, it has severe human health implications if levels exceed 1.5 mg. L−1 in groundwater. Several treatment technologies have been adopted to remove fluoride and reduce the exposure risk. The present article highlights the source, geochemistry, spatial distribution
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Evaluation of renal function in precarious workers exposed to heavy metals in vulnerable scenarios in the metropolitan area of San Luis Potosí, México Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-27 Mariana Alejandra Castro-Mejía, Kelvin Saldaña-Villanueva, Karen Beatriz Méndez-Rodríguez, Manolo Ortega-Romero, Olivier C. Barbier, Francisco Javier Pérez-Vázquez
The aim of the study was to evaluate renal function in three groups of precarious workers: garbage recyclers (REC), quarry workers (CAN), and brick makers (LAD). Samples of urine and blood were collected to evaluate clinical parameters and the metal levels in urine was measured using ICP-MS. REC group had the highest concentrations of chromium in urine (36.03 ± 27.2 µg/l) compared to CAN and LAD groups
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Effects of acute exposure to environmentally realistic tebuconazole concentrations on stress responses of kidney and digestive gland of Lymnaea stagnalis Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-21 Sezgi Somuncu, Harika Atmaca, Suleyman Ilhan
This study aimed to investigate the effects of 24 and 72 h exposure to environmentally relevant concentrations of tebuconazole (TEB) (10, 100 and 500 µg/L) fungicide on the freshwater snail Lymnaea stagnalis. The focus was induction of oxidative stress, alteration of gene expressions and histopathological changes in the kidney and digestive gland. TEB treatment induced a time- and concentration-dependent
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Potential involvement of ferroptosis in BPA-induced neurotoxicity: An in vitro study Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-26 Nita Jangid, Ankita Sharma, Nidhi Srivastava
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Orthogonal assay and QSAR modelling of Tox21 PPARγ antagonist in vitro high-throughput screening assay Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-23 Jacob Ardenkjær-Skinnerup, Ana Caroline Vasconcelos Engedal Nissen, Nikolai Georgiev Nikolov, Niels Hadrup, Gitte Ravn-Haren, Eva Bay Wedebye, Ulla Vogel
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Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-20 Emelie Rietz Liljedahl, Anda Gliga, Helena Korres de Paula, Malin Engfeldt, Anneli Julander, Carola Lidén, Christian Lindh, Karin Broberg
Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure
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Mycotoxin sequestering agent: impact on health and performance of dairy cows and efficacy in reducing AFM1 residues in milk Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-21 D. Costamagna, M. Gaggiotti, A. Smulovitz, A. Abdala, M. Signorini
The objectives of this study were to evaluate the exposure to a diet naturally contaminated with mycotoxins on lactation performance, animal health, and the ability to sequester agents (SA) to reduce the human exposure to AFM1. Sixty healthy lactating Holstein cows were randomly assigned to two groups: naturally contaminated diet without and with the addition of a SA (20 g/cow/d AntitoxCooPil® -60%
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Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-21 Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong
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Integrated transcriptomics and metabolomics reveal the toxic mechanisms of mercury exposure to an endangered species Tachypleus tridentatus Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-15 Mujiao Xie, Yuyuan Bao, Xiaoyong Xie, Ziwei Ying, Guoling Ye, Chunhou Li, Qingyang Guo, Wanling Zhang, Zimeng Luo
Mercury (Hg) pollution is threatening the health of endangered Tachypleus tridentatus whereas the toxic mechanism is still unclear. This study combined transcriptomic and metabolomics technology to reveal the toxic mechanisms of mercury (Hg 2+, 0.025 mg/L) exposing to T. tridentatus larvae for 15 days. Mercury induced cellular toxicity and cardiovascular dysfunction by dysregulating the genes related
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Transcriptomic and proteomic fingerprints induced by the fungicides difenoconazole and metalaxyl in zebrafish embryos Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-20 Fatma Marghany, Steve U. Ayobahan, Gabriela Salinas, Christoph Schäfers, Henner Hollert, Sebastian Eilebrecht
In this study, we applied OMICs analysis to identify substance-specific biomarker candidates, which may act as early indicators for specific ecotoxic modes of actions (MoA). Zebrafish embryos were exposed to two sublethal concentrations of difenoconazole and metalaxyl according to a modified protocol of the OECD test guideline No. 236. At the end of exposure, total RNA and protein were extracted, followed
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Pharmacokinetic characterisation of a valproate Autism Spectrum Disorder rat model in a context of co-exposure to α-Hexabromocyclododecane Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-19 C. Morel, J. Paoli, C. Emond, F. Debaugnies, E.M. Hardy, M. Creta, M. Montagne, P. Borde, A. Van Nieuwenhuyse, R.C. Duca, H. Schroeder, N. Grova
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Runoff of foliar-applied natural fungicides in aquaponics: Implications for fish and nitrification Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-10 Ewumi Azeez Folorunso, Radek Gebauer, Andrea Bohata, Josef Velíšek, Nikola Třešnáková, Petr Dvořák, Aleš Tomčala, Felix Kofi Agbeko Kuebutornye, Jan Mráz
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Aromatic Hydrocarbon Receptor Repressor (AHRR) is a biomarker of ambient air pollution exposure and Coronary Artery Disease (CAD) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-14 Ibrahim Ridany, Reem Akika, Najat Aoun Saliba, Hani Tamim, Kamal Badr, Nathalie Khoueiry Zgheib
Two hundred and twenty subjects were recruited while undergoing cardiac catheterization. AHRR cg05575921 methylation was shown to be significantly decreased in ever smokers compared to never smokers (Mean± SD = 64.2 ± 17.2 vs 80.1 ± 11.1 respectively; P < 0.0001). In addition, higher urinary levels of 2-OHNAP and 2-OHFLU were significantly associated with more AHRR cg05575921 hypomethylation, even
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Cyanobacterial bloom-associated lipopolysaccharides induce pro-inflammatory processes in keratinocytes in vitro Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-12-12 P. Raptová, V. Skočková, P. Babica, I. Sovadinová, E. Sychrová, P. Vídeňská, P. Šplíchalová, O. Vašíček, L. Šindlerová
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Biomarker responses and lethal dietary doses of tau-fluvalinate and coumaphos in honey bees: Implications for chronic acaricide toxicity Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-11-30 María Benito-Murcia, Cristina Botías, Raquel Martín-Hernández, Mariano Higes, Francisco Soler, Marcos Pérez-López, María Prado Míguez-Santiyán, Salomé Martínez-Morcillo
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Promotion of myofibroblast differentiation through repeated treatment of fibroblasts to low concentrations of PM2.5 Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-11-28 Nathan A. Craig, Anne M. Scruggs, Jack P. Berens, Furong Deng, Yahong Chen, J. Timothy Dvonch, Steven K. Huang
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Microplastics and their environmental effects Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-11-22 Paolo Pastorino, Damià Barceló
Microplastics (MPs) are acknowledged as emerging contaminants that pose a substantial threat to the environment. The adverse impacts of MP pollution extend across marine, freshwater, and terrestrial ecosystems, covering regions from the Tropics to the Poles. Although our comprehension of MP behavior has progressed in recent years, it is still difficult to predict exposure hotspots or exposure scenarios
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DNA damage in workers exposed to pigment grade titanium dioxide (TiO2) and association with biomarkers of oxidative stress and inflammation Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-11-25 Sa. Bonetta, M. Macrì, M. Acito, M. Villarini, M. Moretti, Si. Bonetta, D. Bosio, G. Mariella, V. Bellisario, E. Bergamaschi, E. Carraro
The present study was aimed at investigating DNA damage, micronuclei frequency and meta-nuclear alterations in buccal cells of workers involved in pigment-grade TiO2 production (15 exposed and 20 not-exposed). We also assessed associations of genotoxicity biomarkers with oxidative stress/inflammatory biomarkers in urine and exhaled breath condensate (EBC), as well as possible associations between biomarkers
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Secondary exposure to heavy metal in genetically susceptible mice leads to acceleration of autoimmune response Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-11-19 Sara Puente-Marin, Per Hultman, Jimmy Ekstrand, Jesper Bo Nielsen, Said Havarinasab
Exposure to mercury (Hg) and silver (Ag) has been shown to induce autoimmune diseases in genetically susceptible rodents. Here, A.SW mice were initially exposed to HgCl2, AgNO3 or tap water (control) for 3 weeks. After 13 weeks of stoppage, all mice had secondary exposure to 203HgCl2. After secondary exposure, higher and earlier ANoA titers were observed in mice initially exposed to Hg or Ag compared
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The effect of cigarette smoke extract exposure on the size and sexual behaviour of Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-11-22 Athanasios-Stefanos Giannopoulos, Lydia Giannakou, Natalia Gourgoulianni, Eleanna Pitaraki, Rajesh Jagirdar, Periklis Marnas, Panagiotis I. Tzamalas, Erasmia Rouka, Eleni Livanou, Chrissi Hatzoglou, Konstantinos Gourgoulianis, Stefan Lüpold, Wolf U. Blanckenhorn, Sotirios G. Zarogiannis
Drosophila melanogaster is a widely used animal model in human diseases and to date it has not been applied to the study of the impact of tobacco use on human sexual function. Hence, this report examines the effects of different concentrations of cigarette smoke extract (CSE) exposure on the size and sexual behavior of D. melanogaster. Wild-type flies were held in vials containing CSE-infused culture
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Acute and repeated exposures of normal human bronchial epithelial (NHBE) cells culture to particles from a coloured pyrotechnic smoke Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2023-11-24 Violaine Martin de Lagarde, Laurence Chevalier, Clémence Méausoone, Fabrice Cazier, Dorothée Dewaele, Francine Cazier-Dennin, Marion Janona, Cathy Logie, Sophie Achard, Véronique André, Tiphaine Rogez-Florent, Christelle Monteil, Cécile Corbiere