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Ecotoxicity of a representative urban mixture of rare earth elements to rainbow trout juveniles Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-05-16 J. Auclair, E. Roubeau-Dumont, C. André, F. Gagné
Municipal wastewaters contain a peculiar mix of rare earth elements (REEs) dominated by gadolinium (Gd). The sublethal and lethal toxicity was examined in rainbow trout exposed to a representative REE mixture (municipal waswaters) composed of Gd (105 ng/L), Ce (9 ng/L), Nd (8 ng/L), Yb (6.2 ng/L) and Dy (4 ng/L) corresponding to total REEs loading of 137 ng/L. Juveniles were exposed to a mixture of
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Time dynamics models for oxidative stress markers in honey bees (Apis mellifera) following paraquat-induced stress Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-05-15 Jana Biová, Dalibor Kodrík, Martina Janků, Silvie Dostálková, Michael Simone-Finstrom, Marek Petřivalský, Jiří Danihlík
Many agrochemicals disrupt redox homeostasis, yet the dynamics of oxidative stress responses in honey bees (Apis mellifera) remain insufficiently understood. This study established a controlled model to monitor ROS-related markers over time following paraquat injection, using Bayesian modeling to characterize time-dependent changes. We observed a transient rise in hydroperoxides and early fluctuation
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Assessment of genetic damage levels in agricultural workers exposed to pesticides in Paraíba, Brazil Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-05-09 Laís Campos Teixeira de Carvalho-Gonçalves, Patricianny Barreto de Góis Santos, Glauciane Andrade da Silva, Lucas Monteiro Bezerra Pinheiro, Thiago Marcel Galdino Olinto, Adegildo Rolim de Abreu Junior, Márcia Helena Pontieri, Solange Maria de Vasconcelos, Jéssica Pedrosa de Lima, Luiz Gualberto de Andrade Sobrinho, Angela Lima Meneses de Queiroz, Márcia Aparecida Cezar, Juan Carlos Ramos Gonçalves
Pesticide use has transformed agriculture, but improper handling poses serious health and environmental risks. Brazil, a top global pesticide consumer, faces alarming unapproved usage—nearly 80 % of pesticides sold lack approval in at least three OECD countries. This study investigates genotoxic effects on farmers in Paraíba, Brazil, analyzing buccal mucosa cells for DNA and cellular damage. Using
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Effects of PDYN 68-bpVNTR, BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 polymorphisms on opioid-methamphetamine co-use Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-05-08 Merve Ak, Gizem Özer-Uzaldı, Mukaddes Asena Yıldırım, Selin Özkan-Kotiloğlu, Mustafa Danışman, Dilek Kaya-Akyüzlü
To investigate the impact of PDYN 68-bpVNTR, BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572 variations on the susceptibility to opioid-methamphetamine co-use, a total of 532 individuals, including opioid (n = 104), and methamphetamine (n = 166) users as well as opioid and methamphetamine co- users (n = 158) and healthy individuals (n = 104), were included. BDNF rs6265, OPRD1 rs569356 and OPRM1 rs2075572
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Combined exposure to atrazine and phoxim exacerbated the alterations of enzyme activity and abnormal gene expression in earthworms (Eisenia fetida) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-05-07 Jinzhan Li, Jingwen Wang, Fang Shu, Nan Huang, Ru Jia, Yanhua Wang
Multiple pesticides often coexist in soil, potentially leading to interactions among their components, these may detrimentally impact soil organisms. This study assessed the potential risks posed by simultaneous exposure to atrazine (ATR) and phoxim (PHO) on enzyme and transcription levels in earthworms (Eisenia fetida). The results revealed that ATR exhibited higher acute toxicity towards E. fetida
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Long-term joint exposure of outdoor air pollutants and impaired kidney function in Korean adults: A mixture analysis based on a nationwide sample (2007–2019) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-05-06 Seong-Uk Baek, Jin-Ha Yoon
We explored the association between exposure to air pollutant mixture and renal function. A nationwide sample of 69,066 Korean adults was analyzed. The 1-year moving averages of the concentrations of PM10, PM2.5, SO₂, NO₂, CO, and O₃ were estimated using the air pollution modeling. The outcome was estimated glomerular filtration rate (eGFR) value. Quantile-based G-computation analyses were performed
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The Alarming Consequences of Workforce Reductions at the FDA, EPA, NIH and CDC in the United States Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-05-05 Martin van den Berg PhD, Daniel R. Dietrich PhD, Sonja von Aulock PhD, Anna Bal-Price PhD, Michael D. Coleman PhD, Mark T.D. Cronin PhD, Paul Jennings PhD, Angela Mally PhD, Mathieu Vinken PhD, Matthew C. Wright PhD
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Pesticide stress induces spermatozoa DNA damage and morphological abnormalities in Apis mellifera populations Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-30 Vesela Mitkovska, Ivan Stoyanov, Tsenka Chassovnikarova, Penka Vasileva, Plamen Petrov, Evgeniya N. Ivanova
The rising losses of honey bee colonies are causing public concern regarding the species' long-term sustainability. Therefore, this study aimed to assess how pesticide exposure affects DNA damage and morphological traits of drone spermatozoa across different Apis mellifera populations, categorized by varying colony loss rates. Chromatographic analysis identified 24 pesticide residues in bee samples
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Tebuconazole-based fungicide impairs embryonic development of the South African Clawed Frog Xenopus laevis Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-30 Vanessa Ihle, Hannah Flach, Florian Kaminski, Petra Dietmann, Sarah Pfeffer, Susanne J. Kühl
Tebuconazole (TBZ) is a broad-spectrum fungicide that disrupts fungal cell membrane. Due to its extensive application in agriculture, TBZ is frequently detected in aquatic ecosystems, posing potential risks to amphibians. However, the effects of TBZ-based formulations on amphibian development remain poorly understood. The present study investigates the effects of the TBZ-based fungicide Tebucur on
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Evaluation of the interaction between the pesticides chlorantraniliprole and imidacloprid with the ATP-binding cassette transporter G2 (ABCG2): In vitro and in vivo assays Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-29 Esther Blanco-Paniagua, Indira Álvarez-Fernández, Laura Álvarez- Fernández, Alicia Millán-García, Gracia Merino
Pesticides used in agriculture to control pests can also affect non-target animals, such as livestock and humans, through exposure. Pesticide residues found in animal-derived products like milk serve as evidence of exposure in mammals and may pose health risks due to bioaccumulation. Understanding the mechanisms of elimination and toxicity of pesticides is essential to minimize their negative impact
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Cytotoxic and metabolic effects of organic extracts from airborne fine particulate matter (PM2.5) in neuronal cells Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-29 Tatiana Silva, Célia Alves, Margarita G. Evtyugina, Ana S. Dias, Guilherme Martins Pereira, Pérola de Castro Vasconcellos, Maria de Fátima Andrade, Helena Oliveira, Iola F. Duarte
Airborne fine particulate matter (PM2.5) has been linked to neurological diseases, but its cellular and metabolic effects remain incompletely understood. This study assessed the cytotoxic and metabolic impact of PM2.5 samples from São Paulo, Brazil, on SH-SY5Y neuroblastoma cells. Even at low toxicity levels (IC10–IC30), PM2.5 organic extracts induced apoptosis, increased TNF-α secretion, and triggered
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Are glyphosate or glyphosate-based herbicides linked to metabolic dysfunction-associated steatotic liver disease (MASLD)? The weight of current evidence Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-29 Luana Riechelmann-Casarin, Leticia Cardoso Valente, Rosemari Otton, Luís Fernando Barbisan, Guilherme Ribeiro Romualdo
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects around 30 % of the world’s population, increasing its prevalence by 50 % in the last three decades. MASLD pathogenesis is considered multiaxial, involving disturbances in the liver, adipose tissue (AT), and gut microbiome. In parallel with MASLD increasing trends, the total herbicide use has nearly tripled over the last three
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Construction of a toxicity pathway from activation of the TLR4/NF-κB/NLRP3 axis to Parkinson's disease-like non-motor symptoms in mice Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-28 Kaidong Wang, Ge Shi, Yonghang Li, Qi Liu, Qianrong Zhang, Chenyang Wu, Yuxuan Jiao, Yuan Ma, Ai Qi, Min Huang
Bipyridyl herbicides, like paraquat, are among the most widely used herbicides worldwide. Although the lungs are the main target organ for acute exposure to paraquat, chronic exposure to paraquat is thought to induce neurotoxicity and is one of the environmental risk factors for neurodegenerative diseases. In the last two decades, as paraquat has been banned in some regions, diquat has gradually become
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Environmental assessment of steroid endocrine disruptors in stranded cetaceans: A methodological approach to detection and analysis Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-23 Adrián Bullón-Téllez, Zoraida Sosa-Ferrera, José Juan Santana-Rodríguez, Natalia Garcia-Álvarez, Jesús De la Fuente, Manuel Arbelo, Antonio Fernández, Pedro López-Suárez, Carolina Oujo, Katia Freire-Lopes, Rayco Guedes-Alonso
Exploring the presence of endocrine disrupting compounds in marine organisms, particularly cetaceans, is crucial to evaluate contamination within the ocean's food web and the detection of synthetic hormones in cetaceans is a strong indication of anthropogenic pollution in marine ecosystems. Due to their characteristics, blubber samples are a key component in assessing the analysis of cetaceans, but
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Polystyrene microplastics reduce honeybee survival by disrupting gut microbiota and metabolism Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-22 Han Li, Wangjiang Feng, Tong An, Pingli Dai, Yong-Jun Liu
Polystyrene microplastics (PS-MPs) pose significant risks to honeybee health. However, how microplastics (MPs) adversely influence honeybee survival through the gut pathway, especially the metabolic processes, remains poorly understood. To conduct the experiment, the honeybees (Apis mellifera L.) were exposed to PS-MPs (0.5 μm and 5 μm) at environmental concentrations of 25 mg/L and 50 mg/L for 21
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Effect of Bisphenol A on the neuro-immune-endocrine mechanisms controlling the reproductive axis response during an inflammatory event Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-18 Romina Penalba, Juan Manuel Gamez, Nancy Cardoso, Rodrigo M. Bilbao, Osvaldo J. Ponzo, Roxana Reynoso
Endotoxin-induced toxicity could increase with previous exposure to sensitizing agents like endocrine disruptors (EDs). We studied the effects on the reproductive axis on adult male rat pups exposed to BPA since gestation day (GD) 1 to final lactation and its response to LPS before sacrifice. The decrease in GnRH release caused by LPS and BPA was more pronounced in the BPA + LPS group compared to the
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Comparison of the impact of chlordecone and its metabolite chlordecol on genes involved in pesticide metabolism in HepG2 cell line Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-17 Gulminyam Baratzhanova, Hanan EL Sheikh Saad, Agnès Fournier, Marion Huguet, Olivier Joubert, Arnaud Paul, Leyla Djansugurova, Céline Cakir-Kiefer
Chlordecone (CLD) is an organochlorine pesticide that is highly resistant in the environment. This compound and its metabolite chlordecol (CLD-OH) still can be found in the French West Indies, after being banned 30 years ago. The novelty of this work lies in evaluating the toxicity of CLD-OH compared to CLD and examining the effects of these compounds on nuclear receptor (PXR, PPARα, and CAR) and metabolism-related
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Metabolism and genotoxicity of 4,4’-oxydianiline is dependent on N-acetyltransferase 2 genetic polymorphism Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-15 Raul A. Salazar-González, James T.F. Wise, Mark A. Doll, David W. Hein
4,4’-oxydianiline (ODA) is an environmental aromatic amine reasonably anticipated to be a human carcinogen. We investigated ODA genotoxicity and oxidative stress modified by N-acetyltransferase 2 (NAT2) genetic polymorphism in yeast and DNA repair deficient (UV5) Chinese hamster ovary cells (CHO) expressing human NAT2*4 (rapid acetylator allele) or human NAT2*5B (slow acetylator allele) and in cryopreserved
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Pesticide residues in honey: Agricultural landscapes and commercial wax foundation sheets as potential routes of chronic exposure for honey bees Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-15 Deicy C. Munoz Agudelo, Hannah Whitehead, Laura L. Figueroa, Lynn S. Adler
Pesticides pose significant threats to pollinators, and honey bees are frequently exposed through foraging and beekeeping practices. We assessed honey bee pesticide exposure by analyzing 92 pesticide residues in honey from 30 hobbyist apiaries across Massachusetts, along with store-bought honey and commercial wax foundation. For all samples, we calculated the risk of multiresidue toxicity to honey
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Early life developmental effects induced by dioxins and PCBs in novel bioassays with C. elegans Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-15 Cong Bao, Antoine Karengera, Jan Kammenga, Inez Dinkla, Willemien Wieland, AlberTinka J. Murk
This study assessed the effects of TCDD, two PCB mixtures (Clophen A50 and Aroclor 1254), and field extracts from marine sediments and swimming crab tissues on early-life development in Caenorhabditis elegans. Gravid nematodes were exposed on agar, and isolated eggs and larvae were tested in solution. Larval development was evaluated after 72 hours. Reporter gene assays (DR-CALUX) were also used to
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Disruptive ecotoxicological effects of fluoxetine on serotoninergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-10 Kainã Rocha Cabrera Fagundes, Natalia Kasica, Małgorzata Potoczna, Shiho Okitsu-Sakurayama, Piotr Podlasz, Renata de Britto Mari
This study investigated the multilevel effects of environmentally relevant concentrations of fluoxetine on serotonergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio). To this end, zebrafish were exposed to various concentrations of fluoxetine for four days, from the 1,000-cell stage to 4 days post-fertilization (dpf).Following exposure, whole larvae were subjected to molecular
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Effect of Cu(ATSM) on the expression and activity of ABC export proteins in killifish (Fundulus heteroclitus) kidney tubules Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-10 Lisa Kraus, Gert Fricker
ABC transporters are important for excretion of xenobiotics and metabolites into urine. They are sensitive to metallic pollutants like cadmium, mercury, zinc, or arsenic. Here, we show that copper (Cu(ATSM)) stimulates ABC transporter-mediated export in isolated renal proximal tubules from Atlantic killifish (Fundulus heteroclitus) with main focus on Mrp2. Transporter stimulation was reduced by cycloheximide
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Isatin-linked pyrazole K1 derivative alter the phosphatidylinositol-3-kinase pathway by enhancing the metabolic function and folliculogenesis in the triclosan-induced PCOS-like condition in zebrafish model Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-09 Karthikeyan Ramamurthy, Marapatla Shiny, S. Madesh, Santhanam Sanjai Dharshan, Girija Sastry Vedula, Mansour K. Gatasheh, Kathiravan Muthu Kumaradoss, Jesu Arockiaraj
Polycystic ovarian syndrome (PCOS), which causes hormonal imbalance, inflammation, and metabolic disorders, requires several treatments. This study aimed to examine the Isatin-linked pyrazole K1 derivative's effectiveness in PCOS induced by environmental contaminants such as triclosan, specifically assessing its biochemical, metabolic, and reproductive impacts. Isatin-linked pyrazole K1 derivative
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Effects of lithium on mortality and metabolite profiles in Drosophila lithium-inducible SLC6 transporter mutants Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-04-05 Junko Kasuya, Karina Kruth, Dongkeun Lee, Jong Sung Kim, Aislinn Williams, Toshihiro Kitamoto
Lithium has long been the primary treatment for bipolar disorder and shows promise for managing other neurological and psychiatric conditions. We previously identified the Lithium-inducible SLC6 transporter (List) in Drosophila melanogaster as a gene significantly upregulated in response to lithium chloride supplementation. List encodes a putative amino acid transporter belonging to the Na⁺-dependent
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Alleviation of specific responses in the combined exposure of freshwater mussel Unio tumidus to psychoactive substances and microplastics Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-31 K. Yunko, V. Martyniuk, L. Gnatyshyna, V. Khoma, T. Matskiv, H. Tulaidan, O. Mykhalyuk, R. Karitonas, B. Gylyte, L. Manusadžianas, O. Stoliar
The environmentally relevant aquatic pollution is associated with the mixtures of xenobiotics, each in the low, picomolar to micromolar concentrations. Among these substances, the combinations of pharmaceuticals and microplastics (MP) have become an increasingly serious threat. The objective of this study was to track the specific and multi-stress responses of swollen river mussels (Unio tumidus) to
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Environmental pollution and health risks to informal workers: Exposure to heavy metals in human hair at Indonesian landfills Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-30 Azham Umar Abidin, Fina Binazir Maziya, Septian Hadi Susetyo, Arvi Tri Sulistiyani, Minoru Yoneda, Taiki Nagaya, Yasuto Matsui
The concentration of heavy metals (HMs) in human hair is a bioindicator of environmental pollution over a long period from worker, including the informal worker at landfills. A landfill is where final-stage refuse is deposited, transported, and disposed of solid waste from urban areas. No study has been conducted on heavy metals in landfills and their health impact on informal workers. This study aims
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PM10 exposure in beauty salons: impact on A549 cell viability, cell cycle, oxidative stress, and mutagenicity Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-28 Daniela Figueiredo, Estela D. Vicente, Cátia Gonçalves, Isabel Lopes, Célia A. Alves, Helena Oliveira
Beauty salons are unique indoor environments where elevated PM10 levels may arise from frequent use of personal care and cosmetic products, potentially exposing salon workers and clients to harmful chemicals. This study aimed to assess the biological effects of PM10 collected indoors and outdoors of a beauty salon, as well as the mutagenic potential of PM10-bound polycyclic aromatic hydrocarbons (PAHs)
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Environmental pollutants and genetic toxicity: From mechanisms to human studies Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-26 Hilmi Orhan, Marcus S. Cooke
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Neonicotinoid and EBI fungicide in combination hazard the population of red mason bees under field conditions Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-25 Abdulrahim T. Alkassab, Nadine Kunz, Gabriela Bischoff, Dorothee Lüken, Martina Janke, Klaus Wallner, Wolfgang H. Kirchner, Jens Pistorius
Mixing several agrochemicals, e.g., insecticides, fungicides, and herbicides, is a common practice by farmers, enhancing the economic and efficacy of a single application. Their effects on non-target organisms are not routinely evaluated during the authorisation of single products. A field study was conducted in Germany to assess the performance and exposure level of red mason bees after application
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Zebrafish as a model to assess the neurotoxic potential of propylene glycol ethers Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-23 Ramya Deepthi Puligilla, Noëmi Johanna Roos, Jan Stephan Bolten, Nancy B. Hopf, Marie-Gabrielle Zurich, Nikolai Barulin, Jörg Huwyler
Propylene glycol ethers are increasingly used as organic solvents of choice in domestic products and industrial manufacturing. However, little is known about their potential neurotoxic effects. In the present study, we therefore evaluated the acute toxic and behavioral effects of propylene glycol ethers using zebrafish larvae as a vertebrate model. Studied endpoints included viability, motor behavior
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Mother-child exposure to polychlorinated biphenyls and organochlorine pesticides in the Northern Finland cohort (NUGEN) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-23 Saranya Palaniswamy, Soha Salah, Petra Přibylová, Petr Kukučka, Liisa Laatio, Elina Sieppi, Maria Kummu, Arja Rautio, Päivi Myllynen, Khaled Abass
Limited knowledge exists on persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs), in mother-child pairs from Northern Finland. This study examines plasma PCB and OCP concentrations and their determinants. Blood plasma concentrations of 13 PCBs and 6 OCPs were measured in mothers and in cord samples from the NUGEN birth cohort (N = 102
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Single and mixture effect of cyanobacterial metabolites, cylindrospermopsin, anabaenopeptin-A, microginin-FR1 and aeruginosin 98-A, on behaviour, food uptake, oxygen consumption and muscular F-actin degradation of Thamnocephalus platyurus Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-21 Małgorzata Adamczuk, Adam Bownik, Barbara Pawlik-Skowrońska
This study showed that single cyanobacterial metabolites had various effects on the tested parameters. Among them, only cylindrospermopsin was lethal to the animals; cylindrospermopsin was also the most potent inhibitor of the remaining parameters. Cylindrospermopsin in binary mixtures with the other tested metabolites displayed antagonistic or additive effects for survival, movement, food uptake and
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Exposure to a widely used mito-toxic fungicide negatively affects hemolymph protein and vitellogenin levels in honey bees (Apis mellifera) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-16 Adrian Fisher II, Keerut Chahal, Gloria DeGrandi-Hoffman, Brian H. Smith, Jennifer H. Fewell, Jon F. Harrison
Mito-toxic fungicides used in crop protection negatively affect pollinating insects. The fungicide formulation Pristine® (ai: 25.2 % boscalid, 12.8 % pyraclostrobin) induces precocious foraging, reduced lifespan, impaired homing abilities, and reduced body size at field-relevant concentrations. However, the underlying physiological mechanisms for these outcomes are poorly understood. To assess the
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Reliability of pesticide toxicity evaluation: Effects of pesticides on cellular respiration under conventional versus physiological growth conditions Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-15 Kersti Tepp, Giuseppe Leonardo Auditano, Marju Puurand, Tuuli Kaambre
The use of pesticides to enhance crop yields remains prevalent despite persistent concerns about their potential harmful side effects. Moreover, most cell viability studies are conducted in growth media and oxygen concentrations that do not accurately reflect the in vivo conditions in tissues, and therefore may influence the outcomes of toxicity assessments. The aim of the study was to examine how
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Dimethylmonothioarsinic acid (DMMTAV) induces NQO1 expression through coordinated activation of NRF2 and AHR pathways Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-08 Sara R. El-Mahrouk, Ayman O.S. El-Kadi
Dimethylmonothioarsinic acid (DMMTAV), a potent toxic metabolite of arsenic, exhibits higher cytotoxicity than other arsenicals. This study investigates its influence on NAD(P)H:quinone oxidoreductase (NQO1) regulation in C57BL/6 mice and Hepa-1c1c7 cells. Mice were administered DMMTAV (6 mg/kg, IP) with or without TCDD (15 µg/kg, IP), and hepatic and extrahepatic tissues were analyzed for NQO1 expression
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Mitigating pesticide risk on bee pollinators and angiosperm biodiversity in the Ndop wetlands: A conservation approach Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-07 Therese Ncheuveu Nkwatoh, Patricia Bi Asanga Fai, Alvine Larissa Meyabeme Elono, Louis Sevitenyi Nkwatoh, Sali Atanga Ndindeng
This study aimed to assess the risk of pesticides on bee pollinators and propose strategies to conserve entomophilous angiosperm species in the Ndop wetlands. Results showed that the applied pesticide doses were often excessive, increasing the exposure toxicity ratios (ETR). Among the pesticides, insecticides posed the highest risk to bee pollinators, with Emamectin benzoate (ETR=591.4) presenting
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Assessing the toxicity of gadolinium in freshwater and marine ecosystems: Effects across trophic levels Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-06 Camilla Mossotto, Serena Anselmi, Stefania Trevisan, Francesca Provenza, Alessandra Maganza, Alice Gabetti, Giuseppe Esposito, Antonia Concetta Elia, Marino Prearo, Monia Renzi, Paolo Pastorino
Rare Earth Elements, particularly gadolinium (Gd), are increasingly used in industrial and medical applications, leading to their dispersion in aquatic environments. This study examines the ecotoxicological effects of Gd on aquatic organisms across different trophic levels in freshwater and marine ecosystems. Using standardized bioassays, the impact of Gd was assessed on Aliivibrio fischeri, Raphidocelis
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Determination of 5-OH-DMT (bufotenine) in the Asian toad Duttyphrynus melanostictus, Hoplobatrachus tigerinus and Haemopis sanguisiga in Madagascar by UHPLC-MS/MS Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-06 Christina Ververi, Elisah Rasoanomenjanahary Nahavitatsara, Brigitte Annie Bezandry, Vonimanitra Juliana Rasoma Rahantavololona, Cristina Giacoma, Alberto Salomone
5-hydroxy-N,N-dimethyltryptamine (5-OH-DMT), known as bufotenine, is proven to have psychoactive effects in high concentrations. Duttyphrynus melanostictus, which produces bufotenine, has migrated to the city of Toamasina in Madagascar, thus, the determination bufotenine’s levels in the species’ samples is necessary. This study aimed to quantify bufotenine in eggs, tadpoles and toad’s skin samples
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Contaminant-driven midgut histological damage in bees and other aculeate Hymenoptera: A quantitative review Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-04 Carlo Polidori, Chiara Francesca Trisoglio, Andrea Ferrari, Andrea Romano, Francesco Bonasoro
We present a review about histological sub-lethal effects due to anthropogenic contaminants on the midgut of bees and other aculeate hymenopterans. Contaminant types, damage types, and methodology were extracted and summarized from 74 published articles, and then quantitatively analyzed. We found that the Western honeybee (Apis mellifera) is by far the most widely used model. Contaminants have largely
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Sexually dimorphic cardiovascular impacts of prenatal exposure to a real-life environmental chemical mixture in adult offspring Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-03-04 Noor Muhammad Khan, Victoria Scott, Mohammad Ghasemzadeh-Hasankolaei, Vasantha Padmanabhan, Arpita Vyas, Neil P. Evans, Michelle Bellingham
Cardiovascular disease (CVD) is a leading cause of death that is sexually dimorphic. This study used an ovine model to investigate whether maternal exposure to an environmental chemical (EC) mixture (biosolids) prior to and throughout pregnancy, affected offspring cardiovascular (CV) structure and function in adulthood. CV function of male and female offspring from ewes grazed on either conventionally
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Preliminary study on the effect of first- and second-hand smoke of heat-not-burn tobacco products on urinary nicotine and cotinine levels and cardiovascular system Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-27 Dae-Hyeon Kim, Petros Koutrakis, Youn-Suk Son
Heart rate variability (HRV) of 10 participants was assessed to evaluate the impact of exposure to first- and second-hand smoke from heat-not-burn (HnB) products and conventional cigarettes on cardiovascular health and the autonomic nervous system. The nicotine and cotinine concentrations in the urine of smokers and non-smokers exposed to this smoke were also measured. Nicotine levels in the urine
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Genetic variation in the INMT gene strongly impacts the production of trimethylsulfonium in humans Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-24 Olivia Trummer, Carina Maria Laglstorfer, Christoph W. Haudum, Cornelia Missbrenner, Walter Goessler, Barbara Obermayer-Pietsch, Bassam Lajin
We previously identified the trimethylsulfonium ion (TMS) in human urine and highlighted its potential as a novel H2S biomarker but observed significant inter-individual variability in its urinary excretion. In this work we investigate the contribution of genetic factors to this variability in a group of European subjects (n = 100) from the BioPersMed cohort. Urinary TMS concentrations displayed two
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Toxicity and bioaccumulation of nanoparticles of zinc oxide (ZnO) and titanium dioxide (TiO2) in Chydorus sphaericus and Cypridopsis cf. vidua (Crustacea) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-22 Miguel Hernández-Pedraza, Jesús Alvarado-Flores, Marcelo Silva-Briano, Araceli Adabache-Ortiz, Roberto Rico-Martínez
Nanoparticles of titanium dioxide (TiO2) and zinc oxide (ZnO), have great demand and commercial use. Their presence in water reservoirs constitute a potential to produce adverse effects on crustaceans. We used two species of crustaceans: the cladoceran Chydorus sphaericus, and the ostracod Cypridopsis cf. vidua. Cultures were kept in a bioclimatic chamber at 20°C and 25°C respectively. Model organisms
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Chlordecone reduces hyperpolarization-activated-current (Ih) conductance in honeybee Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-19 Patrick Bois, Alain Chavanieu, Christophe Magaud, Nassim Fares, Mahira Kaabeche, Aurelien Chatelier, Pierre Charnet, Thierry Cens
The pacemaker channel (HCN) is responsible for electrical activity in a wide range of excitable cells, including those of invertebrates. Using Xenopus oocytes and HEK cell, we show here that HCN-channel from Apis mellifera is activated by hyperpolarization, modulated by cAMP, and blocked by cesium. Its PNa/PK relative permeability is 1:3, and its unitary conductance is 1.5 pS, which is similar to that
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Platelet and IL-33 count as biomarkers for lung function impairment: An 11-year follow-up study on populations exposed to hexavalent chromium Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-18 Pai Zheng, Yi Zhang, Jiaqi Shi, Zekang Su, Guiping Hu, Yi Bai, Zhangjian Chen, Guang Jia
Recent research has highlighted the crucial role of immune regulation in lung function impairment due to exposure to hazardous materials. This study aimed to identify dynamic network biomarkers for lung function damage caused by hexavalent chromium inhalation exposure, using immune-related indicators in blood. An 11-year follow-up longitudinal study was conducted on a population occupationally exposed
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Environmental exposure to pesticides is associated with oxidative stress, oxidative DNA damage, and elevated interleukin-8 in a child population. Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-18 José Antonio Aguilar-Bañuelos, Yael Yvette Bernal-Hernández, Irma Martha Medina-Díaz, Miguel Alfonso Ruiz-Arias, José Francisco Herrera-Moreno, Briscia Socorro Barrón-Vivanco, Cyndia Azucena González-Arias, Juan Manuel Agraz-Cibrián, José Francisco Zambrano-Zaragoza, Francisco Alberto Verdín-Betancourt, Néstor Ponce Ruiz, Eugenia Flores-Alfaro, Aurora Elizabeth Rojas-García
Pesticide exposure can cause various adverse effects in humans, with children being particularly susceptible. Such exposure leads to neurological, immunological, respiratory, and genetic damage, primarily by generating reactive oxygen species (ROS). The increase in ROS induces lipid peroxidation (LPO) and the formation of hydroxyl radicals, which generate DNA adducts. This study involved children aged
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Effects of anthropogenic stress on stingless bees Melipona mandacaia inhabiting urban and natural environments Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-17 Isabelle Letícia Bender de Souza, Leanna Camila Macarini, Cíntia Mara Ribas de Oliveira, Nuno G.C. Ferreira, Ana Tereza Bittencourt Guimarães
Bees play a crucial role as pollinators, significantly contributing to ecosystem health. However, they face growing threats from human activities. This study uses biomarkers to evaluate the health status of Melipona mandacaia, a stingless bee native to the Caatinga biome, as indicators of anthropogenic stress. Bees were collected from the unique Caatinga biome, which had no recorded human pressure
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Toxic effects of microplastics (polyethylene) exposure on acetylcholinesterase, stress indicators and immunity in Korean Bullhead, Pseudobagrus fulvidraco Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-11 Ju-Hyeong Lee, Jae-Ho Choi, Yue Jai Kang, Young Jae Choi, Cheol Young Choi, Ju-Chan Kang, Jun-Hwan Kim
Microplastics (MPs) in aquatic environments can have toxic effects on various organisms, including fish. This study exposed Pseudobagrus fulvidraco to polyethylene MPs at 0, 10 mg/L (approximately 9.50 ×108 particles/L), 20 mg/L (approximately 1.9 ×109 particles/L), 5000 mg/L (approximately 4.75 ×1011 particles/L), and 10,000 mg/L (approximately 9.50 ×1011 particles/L) concentrations for 96 h. At relatively
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Multi-biomarker approach to assess the toxicity of carbamazepine, a neuropharmaceutical, in the female fish Astyanax lacustris (Teleostei: Characidae) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-11 Amanda da Silveira Guerreiro, Guilherme de Aguiar, Cecilia Bertacini, Filipe Guilherme Andrade de Godoi, Giovana Souza Branco, Renato Massaaki Honji, Larissa Caminhas, Susanne Rath, Renata Guimarães Moreira
Carbamazepine (CBZ) is a pharmaceutical commonly used in the treatment of epilepsy and bipolar disorder and has been detected in different aquatic ecosystems worldwide. Considering its possible role in altering nervous system and reproduction, this study aimed to evaluate the effects of CBZ on molecular and cellular biomarkers of the teleost Astyanax lacustris. Results demonstrated that CBZ, in environmentally
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Toxicokinetic and risk assessment of methylmercury in Indonesian pregnant population using physiologically-based toxicokinetic and reverse dosimetry modelling Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-10 Hasnawati Amqam, Rahayu Indriasari, Wahiduddin, Basir, Yusep Suparman
Methylmercury (MeHg) exposure poses significant risks, especially for pregnant women in Indonesia, where fish consumption is a common dietary habit. This study used a physiologically based toxicokinetic model and reverse dosimetry to estimate MeHg exposure levels and assess health risks in pregnant Indonesian women. The model was validated against biomarker data, with observed MeHg blood levels of
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Analysis of key proinflammatory mechanisms in cardiovascular pathology through stimulation with lipopolysaccharide and urban particulate matter in mouse atrial cardiomyocytes Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-09 Darío Mandaglio-Collados, Antonio José Ruiz-Alcaraz, José Miguel Rivera-Caravaca, María Pilar Ramos-Bratos, Francisco Marín, Raquel López-Gálvez
Air pollution has emerged as one of the leading causes of mortality, aggravating cardiovascular diseases. Urban-particulate matter (PM) can accumulate in the cardiovascular system and through inflammation, trigger systemic damage. One of the key mechanisms of this process could be related to the activation of the inflammasome through the pre-existence of a low-grade endotoxemia and PM presence in the
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Evaluation of sevoflurane volatilization from gel and microsphere formulations and prediction of workplace exposure Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-04 María Trinidad Gómez-Sánchez, F.Dámaso Fernández-Ginés, Sergio Parra, Manuel Gerónimo-Pardo
The general inhalation anesthetic sevoflurane can be used as a topical analgesic in patients with painful wounds. For this new indication, it is irrigated in its liquid formulation into the wound bed, which inevitably causes room pollution. This investigation aimed to analyze the environmental contamination caused by new sevoflurane gel and microsphere formulations at different concentrations (50 %
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Investigating the effects of anthropogenic yttrium contamination: Biochemical alterations in the gills and digestive gland of exposed mussels (Mytilus galloprovincialis) Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-03 João Pinto, Marta Cunha, Carla Leite, Amadeu M.V.M. Soares, Rosa Freitas, Eduarda Pereira
The rapid growth of electronic waste, including fluorescent lamp waste (FLW), has led to an increase in elements like yttrium (Y) and other rare earth elements (REE) in aquatic environments due to improper waste management. However, there are no guidelines for permissible concentrations of these elements in the environment. This study examines the biochemical impacts of varying Y concentrations (50
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Diverse alterations and correlations in antioxidant gene expression in honeybee (Apis mellifera) hemocytes interacting with microbial pathogen-associated molecular patterns and pesticide cocktails Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-02-01 Dani Sukkar, Lea Wagner, Antoine Bonnefoy, Jairo Falla-Angel, Philippe Laval-Gilly
Imidacloprid and amitraz, two common pesticides, affect honeybee health, behavior, and pathogen resistance. Understanding multi-risk exposures is vital to explaining their role in hive performance decline and colony health. This study assessed antioxidant system genes to evaluate pesticide impacts on immune response and enzymes responsible for hydrogen peroxide (H₂O₂) production. Honeybee hemocytes
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Mitigation of experimental hepatocellular Carcinoma by Inonotus obliquus Mushroom extract in association with oxidative stress and inflammation signaling Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-01-30 Zaved Ahmad, Pir Mohammad Ishfaq, Subodh Kumar Jain, Siddhartha Kumar Mishra
Chaga mushroom (Inonotus obliquus) has been a component of folk medicine treating several disorders mainly through its anti-inflammatory and antioxidant properties, yet its effects on liver carcinoma needed elucidation. This study investigated the effect of an aqueous extract of Inonotus obliquus (IOAE) against diethyl-nitrosamine/carbon tetrachloride (DEN/CCl4) induced HCC in mice and addressed its
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Aflatoxin B1-induced DNA adduct formation in murine kidney and liver Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-01-28 Pawel Jaruga, Vladimir L. Vartanian, Irina G. Minko, Miral Dizdaroglu, R. Stephen Lloyd
Aflatoxicosis is a life-threatening nephrotoxic condition arising from eating foods highly contaminated with aflatoxin-producing molds. Additionally, chronic aflatoxin exposures are linked to enhanced hepatocellular carcinomas. Using recent advances in mass spectrometry for the detection of aflatoxin B1 (AFB1) DNA adducts, we present data which show generation of these adducts in the kidney, albeit
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Ex vivo electrophysiological evaluation of peripheral nerve functioning following exposition of adult mice to the organophosphorus pesticide chlormephos Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-01-27 Robert Frangež, Evelyne Benoit
The organophosphorus pesticide chlormephos was tested for its potential peripheral neurotoxicity by analyzing the diphasic compound action potential (CAP) of sciatic nerves isolated from adult mice chronically exposed to a sub-lethal dose of this pesticide, compared with control age-matched animals being only exposed to the vehicle. No significant modification was detected between chlormephos-exposed
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Investigating the multigenerational effects of DDT residues exposure on dental development in Wistar rats Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-01-26 Camilla de Marchi Sanches Azevedo, Fernanda Coleraus, Ana Tereza Bittencourt Guimarães, Christian Kirschneck, Erika Calvano Küchler
The pesticide Dichlorodiphenyltrichloroethane (DDT) and its degradation by-products (Dichlorodiphenyldichloroethane-DDD and dichlorodiphenyldichloroethylene-DDE) are health concerns. This study aimed to investigate the impact of multigenerational exposure to traces of DDD and DDE on odontogenesis Wistar rats were allocated in 4 groups over 2 generations (F1 and F2). Water was provided ad libitum throughout
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Assessing aflatoxin exposure in the United Arab Emirates (UAE): Biomonitoring AFM1 levels in urine samples and their association with dietary habits Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-01-25 Shahd Elabed, Raghad Khaled, Nada Farhat, Mohamed Madkour, Shima A. Mohammad Zadeh, Tamer Shousha, Jalal Taneera, Lucy Semerjian, Khaled Abass
Aflatoxins, known for their carcinoginc properties and produced by Aspergillus fungi, pose a substantial threat to public health, particularly in regions with hot and humid climates, where individuals are exposed to these toxins through contaminated food. The primary objective of this study was to assess the extent of aflatoxin exposure in the Emirate of Sharjah employing Aflatoxin M1 (AFM1) as a biomarker
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Impact of environmentally relevant concentrations of glyphosate on Boana faber tadpoles exposed in the laboratory: Morphological and functional markers Environ. Toxicol. Pharmacol. (IF 4.2) Pub Date : 2025-01-22 Cristiano Roberto Hentges, Laura Kauer Schuck, Carolina De Abreu Caberlon, Alexandro Marques Tozetti, Guendalina Turcato Oliveira
This study evaluated the effects of a glyphosate-based herbicide on the oxidative balance, energy metabolism, and body condition indices in tadpoles of Boana faber. Anuran spawns were collected, and after hatching and reaching Gosner stage 25, they were acclimated and exposed (168 hours) to concentrations of glyphosate (G1: 65, G2: 260, and G3: 520 µg/L). The body condition markers revealed a significant