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Broad toxicological effects of Per-/Poly- fluoroalkyl substances (PFAS) on the unicellular eukaryote, Tetrahymena pyriformis Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-08-07 Jenson Lim
Per-/Poly- fluoroalkyl substances represent emerging persistent organic pollutants. Their toxic effects can be broad, yet little attention has been given to organisms at the microscale. To address this knowledge shortfall, the unicellular eukaryote Tetrahymena pyriformis was exposed to increasing concentrations (0 - 5000 μM) of PFOA/PFOS and monitored for cellular motility, division and function (i
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Dust fall PM2.5-induced lung inflammation in rats is associated with hypermethylation of the IFN-γ gene promoter via the PI3K-Akt-DNMT3b pathway Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-08-04 Jun Bai, Hailan Wang, Siyu Yang, Ji Lu, Chenwen Li, Yaochuan Sun, Tingting Huo, Jianjun Deng, Qingbi Zhang
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Aprepitant exerts anti-fibrotic effect via inhibition of TGF-β/Smad3 pathway in bleomycin-induced pulmonary fibrosis in rats Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-08-02 Mervat Z. Mohamed, Mohamed F. Abed El Baky, Merhan E. Ali, Heba M. Hafez
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Effect of Diacerein on HOTAIR/IL-6/STAT3, Wnt/β-Catenin and TLR-4/NF-κB/TNF-α axes in colon carcinogenesis Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-08-05 Nada H. Eisa, Eman Said, Ahmed E Khodir, Dina Sabry, Hasnaa Ali Ebrahim, Dalia Mahmoud Abdelmonem Elsherbini, Reem Altemani, Dania Mohammed Alnasser, Nehal M Elsherbiny, Mohamed El-Sherbiny
Colorectal cancer (CRC) is a common malignancy with high mortality and poor prognosis. Diacerein (DIA) is an anti-inflammatory used for treatment of osteoarthritis. We delineated some underlying molecular mechanisms of DIA’s anti-carcinogenic effect in CRC using in vivo and in vitro models. Human Caco-2 cells were treated with DIA followed by MTT and Annexin V assays and CRC was experimentally induced
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Relationship between miRNAs polymorphisms and peripheral blood leukocyte DNA telomere length in coke oven workers: A cross-sectional study Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-08-03 Zhifeng Guo, Kaili Zou, Xinling Li, Xiaoran Duan, Yahui Fan, Xiaohua Liu, Wei Wang
Objective The purpose of this study was to investigate the factors affecting telomere length (TL) in coke oven workers by analyzing the interaction between miRNAs polymorphisms and coke oven emissions (COEs) exposure. Methods A total of 544 coke oven workers and 238 healthy controls were recruited. Peripheral blood was collected from the subjects, genomic DNA was extracted, leukocyte TL was detected
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Comparison of biodistribution of cerium oxide nanoparticles after repeated oral administration by gavage or snack in Sprague Dawley rats Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-28 Trine Berthing, Else Holmfred, Janja Vidmar, Niels Hadrup, Alicja Mortensen, Józef Szarek, Katrin Loeschner, Ulla Vogel
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Sulfur dioxide-enhanced asthma susceptibility is involved with inhibition of bitter taste transduction in mouse lung Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-28 XiuJuan Li, HuiLan Yi
Sulfur dioxide (SO2) may induce asthma-like symptoms or worsen existing asthma, but the underlying mechanism is still unclear. In this study, the relationship between SO2 exposure, asthma development, and bitter taste transduction was analyzed using ovalbumin (OVA)-induced and SO2-aggravated asthma models. The results showed that twenty-seven and twelve bitter taste receptors (Tas2rs) were detectable
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Comparison of the antioxidant properties of serum and plasma samples as well as glutathione under environmental and pharmacological stress factors involving different classes of drugs Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-22 Małgorzata Olszowy-Tomczyk, Łukasz Paprotny, Agnieszka Celejewska, Dorota Szewczak, Dorota Wianowska
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Can iron, zinc, copper and selenium status be a prognostic determinant in COVID-19 patients? Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-23 Ayse Basak Engin, Evren Doruk Engin, Atilla Engin
In severe COVID-19, the levels of iron (Fe), copper (Cu), zinc (Zn) and selenium (Se), do not only regulate host immune responses, but modify the viral genome, as well. While low serum Fe concentration is an independent risk factor for the increased death rate, Zn controls oxidative stress, synthesis of inflammatory cytokines and viral replication. Therefore, Zn deficiency associates with a worse prognosis
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Neurotoxicity of singular and combined exposure of Oreochromis niloticus to methomyl and copper sulphate at environmentally relevant levels: Assessment of neurotransmitters, neural stress, oxidative injury and histopathological changes Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-23 Ola A. Habotta, Samia Elbahnaswy, Iman Ibrahim
Aquatic organisms are concomitantly exposed to multiple noxious chemicals that can be discharged into water bodies. We aimed to investigate the single and simultaneous sub-acute exposure to copper and methomyl on juvenile Oreochromis niloticus. Compared to the controls, the outcomes revealed that brain of methomyl-exposed fish displayed significant declines in the activities of SOD, CAT, and GST in
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Efficacy of stem cell-based therapies for colistin-induced nephrotoxicity Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-19 Özlem Öz Gergin, Sibel Seckin Pehlivan, Menekse Ulger, Ozge Cengiz Mat, Adnan Bayram, Zeynep Burçin Gönen, Nur Seda Gökdemir, Cihangir Biçer, Karamehmet Yildiz, Arzu Hanım Yay
The increase in infections with multidrug resistant bacteria has forced to return to the use of colistin, antibiotic with known nephrotoxicity. Mesenchymal stem cells (MSCs) are being extensively investigated for their potential in regenerative medicine. This study aimed to investigate the possible protective mechanisms of the MSCs against kidney injury induced by colistin. Forty adult female albino
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Histological alterations and oxidative stress in adult zebrafish muscle after aluminium exposure Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-20 Ida Ferrandino, Teresa Capriello, Luis M. Félix, Gianluca Di Meglio, Dércia Santos, Sandra M. Monteiro
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Salinity and/or nanoparticles (Al2O3, TiO2) affect metal accumulation and ATPase activity in freshwater fish (Oreochromis niloticus) Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-14 Nagihan Pepe, Esin Gülnaz Canli, Mustafa Canli
The osmoregulation system of freshwater fish is sensitive to salinity increase in water. There is no satisfactory data to our knowledge on the accumulation of metal-oxide nanoparticles (NPs) in tissues of O. niloticus and their effects on ATPases (Na,K-ATPase, Mg-ATPase, Ca-ATPase) in differing salinities. Thus, this study investigated the effects of salinity (0 and 10 ppt) and Al2O3 and TiO2 NPs (1
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Ecotoxicological effects of human and veterinary antibiotics on water flea (Daphnia magna) Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-14 Kafilat A. Bawa-Allah, Aideloje O. Ehimiyein
In the present study, we assessed the ecotoxicological effects of selected human and veterinary antibiotics to D. magna. Ecological risk assessment was done by calculating the risk quotients (RQs) of the antibiotics to the species. Results showed that enrofloxacin, a veterinary fluoroquinolone antibiotic, was the most toxic against D. magna with a 48 h EC50 value of 28.59 mg/l. The binary mixture of
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Effective removal of pharmaceutical contaminants ibuprofen and sulfamethoxazole from water by Corn starch nanoparticles: An ecotoxicological assessment Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-11 Vishnu Priyan V, Selvaraju Narayanasamy
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Multi-biomarker approach and IBR index to evaluate the effects of bisphenol A on embryonic stages of zebrafish (Danio rerio) Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-12 Gerardo Heredia-García, Leobardo Manuel Gómez-Oliván, Gustavo Axel Elizalde-Velázquez, Jesús Daniel Cardoso-Vera, José Manuel Orozco-Hernández, Karina Elisa Rosales-Pérez, Sandra García-Medina, Hariz Islas-Flores, Marcela Galar-Martínez, Octavio Dublán-García
This study assessed the effects of Bisphenol A in embryonic stages of zebrafish, applying an IBR multi-biomarker approach that included alterations in growth and oxidative status and relates it with the expression of Nrf1, Nrf2, Wnt3a, Wnt8a, COX-2, Qdpra, and DKK1 genes. For this purpose, we exposed zebrafish embryos to eight environmentally relevant concentrations of BPA (220, 380, 540, 700, 860
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Multiomics analysis of the impact of polychlorinated biphenyls on environmental liver disease in a mouse model Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-06 Belinda J. Petri, Kellianne M. Piell, Banrida Wahlang, Kimberly Z. Head, Kalina Andreeva, Eric C. Rouchka, Jianmin Pan, Shesh N. Rai, Matthew C. Cave, Carolyn M. Klinge
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Effects of short-term continuous and pulse cadmium exposure on gut histology and microbiota of adult male frogs (Pelophylax nigromaculatus) during pre-hibernation Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-03 Yuyue Wan, Minyi Huang, Xiang Xu, Xiaohong Cao, Hongping Chen, Renyan Duan
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Species, tissue and gender-related metal and element accumulation in fish species in a large reservoir (Turkey) and health risks and nutritional benefits for consumers Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-07 Memet Varol, Emel Kaçar, Muhammet Raşit Sünbül, Abu Reza Md Towfiqul Islam
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Imidacloprid-based commercial pesticide causes behavioral, biochemical, and hematological impairments in Wistar rats Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-03 Bruna Ducatti Tonietto, Ana Olívia Martins Laurentino, Marina Tuerlinckx Costa-Valle, Larissa Vivan Cestonaro, Bibiana Pereira Antunes, Cleofas Sates, Nícolas Guimarães dos Santos, Eliane Dallegrave, Solange Cristina Garcia, Mirna Bainy Leal, Marcelo Dutra Arbo
Imidacloprid (IMI) is a neonicotinoid insecticide employed worldwide for crop protection. IMI’s mode of action occurs through the agonism of postsynaptic nicotinic acetylcholine receptors (nAChRs), with high specificity for insect nAChRs although there are reports of mammals’ toxicity. Studies on IMI’s neurotoxicity are not conclusive; therefore, the aim of this study was to evaluate the subchronic
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Advances in biological moval efficiency can be calculated by using tethods for the sequestration of heavy metals from water bodies: A review Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-07-06 Divya Jyoti, Reshma Sinha, Caterina Faggio
Pollution is a major concern of the modern era as it affects all the principal aspects of the environment, especially the hydrosphere. Pollution with heavy metals has unequivocally threatened aquatic bodies and organisms as these metals are persistent, non-biodegradable, and toxic. Heavy metals tend to accumulate in the environment and eventually in humans, which makes their efficient removal a topic
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Joint action of binary mixtures based on parameter k·ECx from concentration-response curves in long-term toxicity assay Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-30 Na Wang, Huanle Zhang, Xiaoyan Ma, Jingkun Zhang, Jiajing Sun, Xiaochang Wang, Jinhong Zhou, Jiaxuan Wang, Chengmin Ge
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Non-malignant respiratory illness associated with exposure to arsenic compounds in the environment Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-30 Deepa Gandhi, Sneha Bhandari, Sehal Mishra, Rajnarayan R. Tiwari, Subbiah Rajasekaran
Arsenic (As), a toxic metalloid, primarily originates from both natural and anthropogenic activities. Reports suggested that millions of people globally exposed to high levels of naturally occurring As compounds via inhalation and ingestion. There is evidence that As is a well-known lung carcinogen. However, there has been relatively little evidence suggesting its non-malignant lung effects. This review
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Evaluation of toxicity of Personal Care Products (PCPs) in freshwaters: Zebrafish as a model Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-28 Giorgia Zicarelli, Cristiana Roberta Multisanti, Francesca Falco, Caterina Faggio
Personal care products (PCPs) are part of the large and growing family of emerging contaminants (ECs). Many daily products such as sunscreens, toothpaste, make-up products, perfume, and others, fall under this definition, and their use is increasing exponentially. Furthermore, the degradation of some components of these products is limited. Indeed, they are able to easily reach and accumulate in aquatic
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Protective effect of protexin concentrate in reducing the toxicity of chlorpyrifos in common carp (Cyprinus carpio) Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-23 Mahdi Banaee, Antoni Sureda, Caterina Faggio
The present study aimed to evaluate the protective effect of protexin supplementation against chlorpyrifos-induced oxidative stress and immunotoxicity in Cyprinus carpio. After 21 days, the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR), and total antioxidant levels significantly decreased in hepatocytes of fish exposed to chlorpyrifos, while malondialdehyde
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Evaluating the chronic effect of two varroacides using multiple biomarkers and an integrated biological response index Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-27 María Benito-Murcia, Cristina Botías, Raquel Martín-Hernández, Mariano Higes, Francisco Soler, Marcos Perez-Lopez, María Prado Míguez-Santiyán, Salome Martinez-Morcillo
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Cylindrospermopsin induces oocyte maturation and disrupts gene expression in zebrafish ovarian follicles Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-21 Adriana Carvalho Natal de Moraes, Hamideh Pourmohammadi Fallah, Valéria Freitas de Magalhães, Hamid R. Habibi
There is evidence that cylindrospermopsin (CYN) exerts reproductive toxicity in mice. However, little information is available concerning the toxicity of CYN in nonmammalian vertebrates. Here, we investigated the direct action of CYN on female reproduction by studying germinal vesicle breakdown, transcript abundance, caspase-3 activity, and testosterone production using cultured follicle-enclosed zebrafish
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Zinc supplementation prevents arsenic-induced dysregulation of ZRANB2 splice function Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-25 Jonathan C. Bastick, Mayukh Banerjee, J. Christopher States
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Triazole fungicide tebuconazole induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-23 Yosra Ben Othmène, Kevin Monceaux, Anissa Belhadef, Ahmed Karoui, Intidhar Ben Salem, Manel Boussabbeh, Salwa Abid-Essefi, Christophe Lemaire
Tebuconazole (TEB) is a common triazole fungicide that has been widely applied in the treatment of fungal diseases. It is reported that TEB could exert harmful effects on mammals’ health. However, the molecular mechanism involved in TEB toxicity remain undefined. Our study aimed to investigate the mechanisms of TEB-induced toxicity in intestinal cells. We found that TEB stimulates apoptosis through
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Exposure to Polystyrene nanoparticles induces liver damage in rat via induction of oxidative stress and hepatocyte apoptosis Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-17 Noha A.E. Yasin, Mehrez E. El-Naggar, Zainab Sabry Othman Ahmed, Mona K. Galal, Maha M. Rashad, Ahmed M. Youssef, Ebtihal M.M. Elleithy
Plastic products are widely used in different applications. Thus, exposure of human and other organisms to these products may affect their biological system. The current study was conducted to investigate the potential deleterious effect of Polysterene nanoparticles (PS-NPs) on the liver and to state the cellular and molecular mechanisms associated with exposure to PS-NPs.30 male rats were divided
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Pharmaceutical and personal care products as emerging environmental contaminants in Nigeria: A systematic review Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-20 Aliyu Zakari-Jiya, Chiara Frazzoli, Cecilia Nwadiuto Obasi, Bolaji Bernard Babatunde, Kingsley C. Patrick-Iwuanyanwu, Orish E. Orisakwe
The increasingly broad and massive use of pharmaceuticals (human, veterinary) and personal care products in industrially developing nations makes their uncontrolled environmental and ecological impact a true concern. Focusing on Nigeria, this systematic literature search (databases: PubMed, ScienceDirect, Google Scholar, EMBASE, Scopus, Cochrane library and African Journals Online) aims to increase
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Effects of fluoride exposure on mitochondrial function: Energy metabolism, dynamics, biogenesis and mitophagy Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-20 Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio-Trejo, Marco Antonio Sanchez-Guerra, Olivier Christophe Barbier
Fluoride is ubiquitous in the environment. Furthermore, drinking water represents the main source of exposure to fluoride for humans. Interestingly, low fluoride concentrations have beneficial effects on bone and teeth development; however, chronic fluoride exposure has harmful effects on human health. Besides, preclinical studies associate fluoride toxicity with oxidative stress, inflammation, and
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Developmental exposure to real-life environmental chemical mixture programs a testicular dysgenesis syndrome-like phenotype in prepubertal lambs Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-20 Chris S. Elcombe, Ana Monteiro, Matthew R. Elcombe, Mohammad Ghasemzadeh-Hasankolaei, Kevin D. Sinclair, Richard Lea, Vasantha Padmanabhan, Neil P. Evans, Michelle Bellingham
Current declines in male reproductive health may, in part, be driven by anthropogenic environmental chemical (EC) exposure. Using a biosolids treated pasture (BTP) sheep model, this study examined the effects of gestational exposure to a translationally relevant EC mixture. Testes of 8-week-old ram lambs from mothers exposed to BTP during pregnancy contained fewer germ cells and had a greater proportion
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Toxic effects of pristine and aged polystyrene microplastics on selective and continuous larval culture of acorn barnacle Amphibalanus amphitrite. Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-18 Rabia Nousheen, Daniel Rittschof, Imran Hashmi
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Toxicity of palytoxin, purified ovatoxin-a, ovatoxin-d and extracts of Ostreopsis cf. ovata on the Caco-2 intestinal barrier model Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-17 Marin-Pierre Gémin, Rachelle Lanceleur, Lisa Meslier, Fabienne Hervé, Damien Réveillon, Zouher Amzil, Eva Ternon, Olivier P. Thomas, Valérie Fessard
Human intoxications in the Mediterranean Sea have been linked to blooms of the dinoflagellate Ostreopsis cf. ovata, producer of palytoxin (PlTX)-like toxins called ovatoxins (OVTXs). Exposure routes include only inhalation and contact, although PlTX-poisoning by seafood has been described in tropical regions. To address the impact of OVTXs on the intestinal barrier, dinoflagellate extracts, purified
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Influence of temperature on growth, development and thyroid metabolism of American bullfrog tadpoles (Lithobates catesbeianus) exposed to the herbicide tebuthiuron Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-16 Suelen C. Grott, Nicole Israel, Daína Lima, Daiane Bitschinski, Gustavo Abel, Thiago C. Alves, Elizia B. da Silva, Claudia A.C. de Albuquerque, Jacó J. Mattos, Afonso C.D. Bainy, Eduardo A. de Almeida
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Effects of polyethylene terephthalate microplastic on germination, biochemistry and phytotoxicity of Cicer arietinum L. and cytotoxicity study on Allium cepa L Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-13 Naba Kumar Mondal, Susmita Kundu, Priyanka Debnath, Arghadip Mondal, Kamalesh Sen
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Protective effect of empagliflozin on gentamicin-induced acute renal injury via regulation of SIRT1/NF-κB signaling pathway Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-11 Sandy R. Botros, Asmaa I. Matouk, Aliaa Anter, Mohamed M.A. Khalifa, Gehan H. Heeba
Gentamicin is a highly effective antibiotic. However, its major complication is nephrotoxicity. This study investigated the beneficial effects of empagliflozin against gentamicin-induced nephropathy. Kidney damage was induced in male Wistar rats by administration of gentamicin (100 mg/kg/day, i.p.) for 8 days. Two doses of empagliflozin (10 and 20 mg/kg, p.o.) were concomitantly given with gentamicin
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Evidences of the radiofrequency exposure on the antioxidant status, potentially contributing to the inflammatory response and demyelination in rat brain Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-11 Anjali Sharma, Sadhana Shrivastava, Asha Singh, Shamli S. Gupte, Arti Rathour, Mohd Salim Reshi, Sangeeta Shukla
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MicroRNAs as serum biomarker for Senecio brasiliensis poisoning in cattle Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-11 Evelyn Winter, Julia Cisilotto, André L.F. Goetten, Ângela Veiga, Adriano T. Ramos, Francielli C. Zimermann, Carolina Reck, Tânia B. Creczynski-Pasa
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Effects of UGT2B7 rs7662029 and rs7439366 polymorphisms on sublingual buprenorphine metabolism in heroin addicts: An improved PCR-RFLP assay for the detection of rs7662029 polymorphism Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-10 Dilek Kaya-Akyüzlü, Selin Özkan-Kotiloğlu, Ceylan Bal, Şafak Yalçın-Şahiner, Gamze Avcıoğlu, Mustafa Danışman
This study aimed to determine the effects of UGT2B7 rs7662029 and rs7439366 polymorphisms on plasma buprenorphine (BUP) concentration and different treatment responses in a sample of 109 patients with opioid use disorder (OUD) treated with sublingual BUP/naloxone. Polymorphisms were analysed by PCR-RFLP. Plasma concentrations of BUP and its metabolite norbuprenorphine were detected by LC–MS/MS. Craving
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Risk of preeclampsia among women living in coastal areas impacted by sargassum strandings on the French Caribbean island of Martinique Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-06-06 Donatien Bahezre de Lanlay, Alice Monthieux, Rishika Banydeen, Mehdi Jean-Laurent, Dabor Resiere, Moustapha Drame, Remi Neviere
Objective To investigate preeclampsia risk of pregnant women living in coastal areas regularly impacted by massive sargassum strandings. Design Retrospective cohort study Settings and population Pregnant women (n = 3020), seen at the University Hospital of Martinique, were included between 25/01/2016 and 31/07/2020. Methods Patient records were retrospectively reviewed. Distance from coastline sargassum
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Relationship between lifespan and somatic mutation in D. melanogaster after treatment with chlorophyllin Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-30 Martha Patricia Cruces, Elena González, Emilio Pimentel, Elizabeth Jiménez, Petra Sánchez
Sodium copper chlorophyllin (SCC) has a genetic damage inhibitory capacity due to its antioxidant action. For this reason, it was considered to investigate its role in the life span of Drosophila melanogaster and its relationship with the frequency of somatic mutation induced by gamma rays. Results indicated that SCC alone prolonged the lifespan only in females, but in combination with 20 Gy of gamma
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Rotenone mediated developmental toxicity in Drosophila melanogaster Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-30 P. Pramod Kumar, Saliya S. Bawani, Duraiswamy Usha Anandhi, K.V. Harish Prashanth
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CORAL: Development of a hybrid descriptor based QSTR model to predict the toxicity of dioxins and dioxin-like compounds with correlation intensity index and consensus modelling Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-30 Parvin Kumar, Ashwani Kumar, Devender Singh
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Comparison of cellular mechanisms induced by pharmaceutical exposure to caffeine and its combination with salicylic acid in mussel Mytilus galloprovincialis Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-19 Giuseppe De Marco, Sabrine Afsa, Mariachiara Galati, Barbara Billè, Vincenzo Parrino, Hedi ben Mansour, Tiziana Cappello
Urban and hospital-sourced pharmaceuticals are continuously discharged into aquatic environments, threatening biota. To date, their impact as single compounds has been widely investigated, whereas few information exists on their effects as mixtures. We assessed the time-dependent biological impact induced by environmental concentrations of caffeine alone (CAF; 5 ng/L to 10 µg/L) and its combination
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Differential effects of fluoxetine on the phototactic behavior of 3 amphipod species (Crustacea; Amphipoda) Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-20 Melissa Doot Kennedy, Victoria P. Connaughton
We document phototactic responses in different amphipod populations of Gammarus minus, Stygobromus tenuis, and Crangonyx shoemakeri, each collected at 2–3 sites within the Washington DC area. We then assessed how baseline phototaxis was altered following either short-term (3-week) or long-term (6-week) exposure to 0.05 µg/L or 0.5 µg/L fluoxetine. Our results classify all species as significantly photonegative
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Acrolein, an environmental toxicant and its applications to in vivo and in vitro atherosclerosis models: An update Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-22 Liana N. Crowley, Brandy L. Le, Cara Cicalo, Justin Brown, Yali Li, Young Jun Kim, Jin Hyup Lee, Jeong Hoon Pan, Shannon L. Lennon, Bok Kyung Han, Jae Kyeom Kim
Cardiovascular disease, the foremost cause of death worldwide, is an overarching disease term that encompasses a number of disorders involving the heart and circulatory system, including atherosclerosis. Atherosclerosis is a primary cause of cardiovascular diseases and is caused by buildup of plaque and narrowing of blood vessels. Epidemiological studies have suggested that environmental pollutants
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Effects of di-(2-ethylhexyl) phthalate (DEHP) on behavior and dopamine signaling in zebrafish (Danio rerio) Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-17 Wenlong Huang, Jiefeng Xiao, Xiaoling Shi, Shukai Zheng, Haiyi Li, Caixia Liu, Kusheng Wu
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Subacute and sublethal ingestion of microcystin-LR impairs lung mitochondrial function by an oligomycin-like effect Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-20 Flávia Muniz de Mesquita, Dahienne Ferreira de Oliveira, Dayene de Assis Fernandes Caldeira, João Paulo Cavalcante de Albuquerque, Leonardo Matta, Caroline Coelho de Faria, Itanna Isis Araujo de Souza, Christina Maeda Takiya, Rodrigo Soares Fortunato, José Hamilton Matheus Nascimento, Sandra Maria Feliciano de Oliveira Azevedo, Walter Araujo Zin, Leonardo Maciel
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Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-20 Dorinda Marques-da-Silva, Paula Alexandra Videira, Ricardo Lagoa
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Biochemical and body condition markers in Rhinella icterica tadpoles exposed to atrazine, glyphosate, and quinclorac based herbicides in ecologically relevant concentrations Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-13 Leici Maria Machado Reichert, Diogo Reis de Oliveira, Jonas Londero Papaleo, Artur Antunes Navarro Valgas, Guendalina Turcato Oliveira
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A study on bisphenol S induced nephrotoxicity and assessment of altered downstream kidney metabolites using gas chromatography–mass spectrometry based metabolomics Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-10 Kapil Mandrah, Veena Jain, Shagun Shukla, Jamal Ahmad Ansari, Pankaj Jagdale, Anjaneya Ayanur, Vikas Srivastava, Somendu Kumar Roy
The global use of bisphenol S (BPS) has now been significantly increased for commensurate utilization as a substitute for BPA for its regulatory concerns. Though, previous reports indicated that BPS been also appeared as a toxic congener comparable to BPA. In the present study, we determined nephrotoxicity condition induced due to BPS exposure. Results indicated that BPS significantly promoted histopathological
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In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-10 Eliška Sychrová, Affiefa Yawer, Petra Labohá, Amrita Basu, Aneta Dydowiczová, Ishita Virmani, Pavel Babica, Iva Sovadinová
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Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-10 Nuanyi Liang, Shiva Emami, Kelley T. Patten, Anthony E. Valenzuela, Christopher D. Wallis, Anthony S. Wexler, Keith J. Bein, Pamela J. Lein, Ameer Y. Taha
Chronic exposure to traffic-related air pollution (TRAP) is known to promote systemic inflammation, which is thought to underlie respiratory, cardiovascular, metabolic and neurological disorders. It is not known whether chronic TRAP exposure dampens inflammation resolution, the homeostatic process for stopping inflammation and repairing damaged cells. In vivo, inflammation resolution is facilitated
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Risk evaluation of occupational exposure of southern Brazilian flower farmers to pesticides potentially leading to cholinesterase inhibition and metals exposure Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-07 Raul Gomes Aguera, Camila da Silva Freires, Luís Otavio de Oliveira, Lucilena Rebelo Monteiro, Renata Sano Lini, Jéssica Cristina Zoratto Romoli, Bruna Moreira Freire, Samuel Botião Nerilo, Miguel Machinski Junior, Bruno Lemos Batista, Simone Aparecida Galerani Mossini
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Environmentally relevant manganese concentrations evoke anxiety phenotypes in adult zebrafish Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-04 Sabrina Antunes Ferreira, Julia Sepel Loreto, Matheus Mülling dos Santos, Nilda Vargas Barbosa
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D-Ribose-LCysteine attenuates manganese-induced cognitive and motor deficit, oxidative damage, and reactive microglia activation Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-05-02 Grace T. Akingbade, Omamuyovwi M. Ijomone, Aminu Imam, Michael Aschner, Moyosore S. Ajao
Due to overexposure, manganese (Mn) accumulation in the brain can trigger the inhibition of glutathione synthesis and lead to increased generation of reactive oxygen species (ROS) and oxidative stress. D-Ribose-L-Cysteine (RibCys) has been demonstrated to effectively support glutathione synthesis to scavenge ROS and protect cells from oxidative damage. In the present study, we examined the effects
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Hematological effects of glyphosate in mice revealed by traditional toxicology and transcriptome sequencing Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-04-27 Yuhong He, Fei Xiong, Yongkang Qian, Kai Xu, Yunqiu Pu, Jiawei Huang, Manman Liu, Lihong Yin, Juan Zhang, Yuepu Pu, Rongli Sun
The herbicide glyphosate is being used worldwide. Hematological toxicity caused by glyphosate exposure has been reported, but the underlying mechanisms remain unclear. In this study, classical toxicology methods and RNA sequencing were performed to explore the molecular mechanisms related to glyphosate hematotoxicity. We found that 500 mg/kg b.w. glyphosate-based herbicide (GBH) significantly decreased
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Neuro-hepatopathological changes in juvenile Oreochromis niloticus exposed to sublethal concentrations of commercial herbicides Environ. Toxicol. Pharmacol. (IF 5.785) Pub Date : 2022-04-29 Shaimaa M.M. Saleh, Ibrahim A. Mohamed, Mohamed Fathy, Alaa El-Din H Sayed