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Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth Environ. Int. (IF 7.577) Pub Date : 2021-02-25 Yu Zhang; Vicente Mustieles; Paige L. Williams; Blair J. Wylie; Irene Souter; Antonia M. Calafat; Melina Demokritou; Alexandria Lee; Stylianos Vagios; Russ Hauser; Carmen Messerlian
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Ambient PM2.5 species and ultrafine particle exposure and their differential metabolomic signatures Environ. Int. (IF 7.577) Pub Date : 2021-02-24 Feiby L. Nassan; Cuicui Wang; Rachel S. Kelly; Jessica A. Lasky-Su; Pantel S. Vokonas; Petros Koutrakis; Joel D. Schwartz
Background The metabolomic signatures of short- and long-term exposure to PM2.5 have been reported and linked to inflammation and oxidative stress. However, little is known about the relative contribution of the specific PM2.5 species (hence sources) that drive these metabolomic signatures. Objectives We aimed to determine the relative contribution of the different species of PM2.5 exposure to the
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Size-dependent adverse effects of microplastics on intestinal microbiota and metabolic homeostasis in the marine medaka (Oryzias melastigma) Environ. Int. (IF 7.577) Pub Date : 2021-02-24 Xu Zhang; Kai Wen; Dongxiao Ding; Jintao Liu; Zhao Lei; Xiaoxuan Chen; Guozhu Ye; Jie Zhang; Heqing Shen; Changzhou Yan; Sijun Dong; Qiansheng Huang; Yi Lin
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Prenatal exposure to bisphenols and cognitive function in children at 7 years of age in the Swedish SELMA study Environ. Int. (IF 7.577) Pub Date : 2021-02-23 Carl-Gustaf Bornehag; Elin Engdahl; Maria Unenge Hallerbäck; Sverre Wikström; Christian Lindh; Joëlle Rüegg; Eva Tanner; Chris Gennings
Background Experimental evidence demonstrates that exposure to bisphenol A (BPA), and the recently introduced alternatives bisphenol S (BPS) and bisphenol F (BPF) alter normal neurodevelopment. More research is needed to evaluate the associations between exposure to individual BPA alternatives and neurodevelopmental outcomes in humans. Objective The present study aimed at examining the individual associations
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A new LC/MS method for specific determination of human systemic exposure to bisphenol A, F and S through their metabolites: Application to cord blood samples Environ. Int. (IF 7.577) Pub Date : 2021-02-23 C.A. Gély; A. Huesca; N. Picard-Hagen; P.L. Toutain; A. Berrebi; G. Gauderat; V. Gayrard; M.Z. Lacroix
Due to restriction of the use of BPA, several structural analogues such as BPS and BPF have been proposed for its replacement in many consumer products. This has increased the prevalence of BPS and BPF in urine from tested cohorts. However, these substitutes have similar endocrine disrupting properties to BPA, particularly on reproductive and metabolic functions, which suggests that fetal exposure
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Towards guidelines for time-trend reviews examining temporal variability in human biomonitoring data of pollutants Environ. Int. (IF 7.577) Pub Date : 2021-02-21 Brij Mohan Sharma; Jiří Kalina; Paul Whaley; Martin Scheringer
In the last few decades, a plethora of studies have focused on human biomonitoring (HBM) of chemical pollutants. Reviewing the copious HBM data reported in these studies is essential for evaluating the effectiveness of pollution management efforts, for example by evaluating time-trends. Nevertheless, guidance to systematically evaluate time trends in published HBM data has never been developed. In
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Per- and polyfluoroalkyl substances and calcifications of the coronary and aortic arteries in adults with prediabetes: Results from the diabetes prevention program outcomes study Environ. Int. (IF 7.577) Pub Date : 2021-02-22 Citlalli Osorio-Yáñez; Marco Sanchez-Guerra; Andres Cardenas; Pi-I. D. Lin; Russ Hauser; Diane R. Gold; Ken P. Kleinman; Marie-France Hivert; Abby F. Fleisch; Antonia M. Calafat; Thomas F. Webster; Edward S. Horton; Emily Oken
Background Per- and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals that have been associated with cardiovascular risk factors including elevated body weight and hypercholesterolemia. Therefore, PFAS may contribute to the development of atherosclerosis and cardiovascular disease (CVD). However, no previous study has evaluated associations between PFAS exposure and arterial calcification
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Antibiotic exposure decreases soil arsenic oral bioavailability in mice by disrupting ileal microbiota and metabolic profile Environ. Int. (IF 7.577) Pub Date : 2021-02-20 Meng-Ya Li; Xiao-Qiang Chen; Jue-Yang Wang; Hong-Tao Wang; Xi-Mei Xue; Jing Ding; Albert L. Juhasz; Yong-Guan Zhu; Hong-Bo Li; Lena Q. Ma
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A global overview of the trophic structure within microbiomes across ecosystems Environ. Int. (IF 7.577) Pub Date : 2021-02-20 Wu Xiong; Alexandre Jousset; Rong Li; Manuel Delgado-Baquerizo; Mohammad Bahram; Ramiro Logares; Benjamin Wilden; Gerard Arjen de Groot; Nathalie Amacker; George A. Kowalchuk; Qirong Shen; Stefan Geisen
The colossal project of mapping the microbiome on Earth is rapidly advancing, with a focus on individual microbial groups. However, a global assessment of the associations between predatory protists and their bacterial prey is still missing at a cross-ecosystem level. This knowledge is critical to better understand the importance of top-down links in structuring microbiomes. Here, we examined 38 sequence-based
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Fouling potentials and properties of foulants in an innovative algal-sludge membrane bioreactor Environ. Int. (IF 7.577) Pub Date : 2021-02-21 Li Sun; Yu Tian; Hui Li; Qiong Wang
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Estimation of ambient PM2.5 in Iraq and Kuwait from 2001 to 2018 using machine learning and remote sensing Environ. Int. (IF 7.577) Pub Date : 2021-02-19 Jing Li; Eric Garshick; Jaime E. Hart; Longxiang Li; Liuhua Shi; Ali Al-Hemoud; Shaodan Huang; Petros Koutrakis
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Early occupational exposure to lead on neutrophil-to-lymphocyte ratio and genotoxicity Environ. Int. (IF 7.577) Pub Date : 2021-02-19 Yu Meng; Kan Wang; Tuanwei Wang; Yuting Tu; Shiyang Gong; Yunxia Zhang; Guanghui Zhang; William Au; David C. Christiani; Zhao-lin Xia
Background Lead (Pb) is known to induce detrimental health effects in exposed populations, including hematotoxicity and genotoxicity. Complete blood count (CBC) is a cost-effective and easy way to determine toxicity, and variations in proportion of different types of leukocytes: neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR) are further evidence of hematotoxicity. However
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Maternal phthalate urine concentrations, fetal growth and adverse birth outcomes. A population-based prospective cohort study Environ. Int. (IF 7.577) Pub Date : 2021-02-17 Susana Santos; Chalana M. Sol; Charissa van Zwol – Janssens; Elise M. Philips; Alexandros G. Asimakopoulos; Maria-Pilar Martinez-Moral; Kurunthachalam Kannan; Vincent W.V. Jaddoe; Leonardo Trasande
Importance Exposure to phthalates may affect fetal growth, but previous studies are inconsistent and have not explored the trimester-specific effects of phthalates on repeated measures of fetal growth. Objective To assess the associations of maternal phthalate metabolites urine concentrations with fetal growth measures and birth outcomes and identify potential windows of vulnerability to exposure.
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Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort Environ. Int. (IF 7.577) Pub Date : 2021-02-17 Anna Birukov; Louise Bjørkholt Andersen; Marianne Skovsager Andersen; Julie H. Nielsen; Flemming Nielsen; Henriette Boye Kyhl; Jan Stener Jørgensen; Philippe Grandjean; Ralf Dechend; Tina Kold Jensen
Background Previous studies of association between exposure to poly- and perfluoroalkyl substances (PFAS) and gestational hypertension (GH) and preeclampsia (PE) have shown conflicting results, but most dichotomized outcome and did not study continuous blood pressure (BP) changes. Objectives To study the association between PFAS exposure in early pregnancy and maternal BP trajectories in pregnancy
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Sustained bloodstream release of persistent organic pollutants induced by extensive weight loss after bariatric surgery: Implications for women of childbearing age Environ. Int. (IF 7.577) Pub Date : 2021-02-18 Patrick Fénichel; Patrick Coquillard; Françoise Brucker-Davis; Philippe Marchand; German Cano-Sancho; Mireille Boda; Jean-Philippe Antignac; Antonio Iannelli; Jean Gugenheim; Bruno Le Bizec; Nicolas Chevalier
Background Lipophilic persistent organic pollutants (POPs) are stored in adipose tissues and released in case of weight loss. Objectives To analyze the kinetics and characteristics of this release during drastic weight loss after bariatric surgery and compare the results in case of women of childbearing age (WCBA) with critical blood concentration thresholds. Methods 100 morbidly obese patients (73
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Wood emissions and asthma development: Results from an experimental mouse model and a prospective cohort study Environ. Int. (IF 7.577) Pub Date : 2021-02-18 Kristin M. Junge; Lisa Buchenauer; Elena Elter; Katja Butter; Tibor Kohajda; Gunda Herberth; Stefan Röder; Michael Borte; Wieland Kiess; Martin von Bergen; Jan C. Simon; Ulrike E. Rolle-Kampczyk; Irina Lehmann; Richard Gminski; Martin Ohlmeyer; Tobias Polte
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The effect of occupational exposure to noise on ischaemic heart disease, stroke and hypertension: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-Related Burden of Disease and Injury Environ. Int. (IF 7.577) Pub Date : 2021-02-18 Liliane R. Teixeira; Frank Pega; Angel M. Dzhambov; Alicja Bortkiewicz; Denise T. Correa da Silva; Carlos A.F. de Andrade; Elzbieta Gadzicka; Kishor Hadkhale; Sergio Iavicoli; Martha S. Martínez-Silveira; Małgorzata Pawlaczyk-Łuszczyńska; Bruna M. Rondinone; Jadwiga Siedlecka; Antonio Valenti; Diana Gagliardi
Background The World Health Organization (WHO) and the International Labour Organization (ILO) are developing joint estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large number of individual experts. Evidence from mechanistic data suggests that occupational exposure to noise may cause cardiovascular disease (CVD). In this paper, we present
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Short-term exposure to sulphur dioxide (SO2) and all-cause and respiratory mortality: A systematic review and meta-analysis Environ. Int. (IF 7.577) Pub Date : 2021-02-15 Pablo Orellano; Julieta Reynoso; Nancy Quaranta
Background Many studies have assessed the harmful effects of ambient air pollution on human mortality, but the evidence needs further exploration, analysis, and refinement, given the large number of studies that have been published in recent years. The objective of this study was to evaluate all the available evidence of the effect of short-term exposure to ambient sulphur dioxide (SO2) on all-cause
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Short-term exposure to ozone, nitrogen dioxide, and sulphur dioxide and emergency department visits and hospital admissions due to asthma: A systematic review and meta-analysis Environ. Int. (IF 7.577) Pub Date : 2021-02-15 Xue-yan Zheng; Pablo Orellano; Hua-liang Lin; Mei Jiang; Wei-jie Guan
Background Air pollution is a major environmental hazard to human health and a leading cause of morbidity for asthma worldwide. Objectives To assess the current evidence on short-term effects (from several hours to 7 days) of exposure to ozone (O3), nitrogen dioxide (NO2), and sulphur dioxide (SO2) on asthma exacerbations, defined as emergency room visits (ERVs) and hospital admissions (HAs). Methods
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Concentration-dependent health effects of air pollution in controlled human exposures Environ. Int. (IF 7.577) Pub Date : 2021-02-15 Juma Orach; Christopher F. Rider; Christopher Carlsten
Background Air pollution is a leading contributor to premature mortality worldwide and is often represented by particulate matter (PM), a key contributor to its harmful health effects. Concentration-response relationships are useful for quantifying the effects of air pollution in relevant populations and in considering potential effect thresholds. Controlled human exposures can provide data on acute
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Evidence for selection of multi-resistant E. coli by hospital effluent Environ. Int. (IF 7.577) Pub Date : 2021-02-13 Nadine Kraupner; Marion Hutinel; Kilian Schumacher; Declan A. Gray; Maja Genheden; Jerker Fick; Carl-Fredrik Flach; D.G. Joakim Larsson
There is a risk that residues of antibiotics and other antimicrobials in hospital and municipal wastewaters could select for resistant bacteria. Still, direct experimental evidence for selection is lacking. Here, we investigated if effluent from a large Swedish hospital, as well as influent and effluent from the connected municipal wastewater treatment plant (WWTP) select for antibiotic resistant Escherichia
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Spatiotemporal variations in the association between particulate matter and airborne bacteria based on the size-resolved respiratory tract deposition in concentrated layer feeding operations Environ. Int. (IF 7.577) Pub Date : 2021-02-11 Zonggang Li; Weichao Zheng; Yang Wang; Baoming Li; Yuxin Wang
Bacterial loading aggravates the health and environmental hazards of particulate matter (PM), particularly in concentrated animal feeding operations. Understanding the association between PM and airborne bacteria is conducive to accurately assessing occupational exposure, providing fundamental data for exposure mitigation via engineering solutions, and providing information regarding the physical properties
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Total mercury concentration in placental tissue, a good biomarker of prenatal mercury exposure, is associated with risk for neural tube defects in offspring Environ. Int. (IF 7.577) Pub Date : 2021-02-10 Mingkun Tong; Jingru Yu; Ming Liu; Zhiwen Li; Linlin Wang; Chenghong Yin; Aiguo Ren; Laiguo Chen; Lei Jin
Objective To examine the role of total mercury (T-Hg) in placenta as a biomarker of prenatal mercury (Hg) exposure and determine the association between prenatal Hg exposure and risk for neural tube defects (NTDs) in offspring. Methods Total Hg concentrations in placental tissue were detected in 408 NTD cases and 593 healthy controls enrolled in Shanxi province in northern China. Methylmercury (MeHg)
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Showcasing the potential of wastewater-based epidemiology to track pharmaceuticals consumption in cities: Comparison against prescription data collected at fine spatial resolution Environ. Int. (IF 7.577) Pub Date : 2021-02-09 M. Escolà Casas; N.S. Schröter; I. Zammit; M. Castaño-Trias; S. Rodriguez-Mozaz; P. Gago-Ferrero; Ll. Corominas
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Seasonal changes dominate long-term variability of the urban air microbiome across space and time Environ. Int. (IF 7.577) Pub Date : 2021-02-09 Andrés Núñez; Ana M. García; Diego A. Moreno; Raúl Guantes
Compared to soil or aquatic ecosystems, the atmosphere is still an underexplored environment for microbial diversity. In this study, we surveyed the composition, variability and sources of microbes (bacteria and fungi) in the near surface atmosphere of a highly populated area, spanning ~ 4,000 Km2 around the city center of Madrid (Spain), in different seasonal periods along two years. We found a core
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Impacts of primary emissions and secondary aerosol formation on air pollution in an urban area of China during the COVID-19 lockdown Environ. Int. (IF 7.577) Pub Date : 2021-02-09 Jie Tian; Qiyuan Wang; Yong Zhang; Mengyuan Yan; Huikun Liu; Ningning Zhang; Weikang Ran; Junji Cao
Restrictions on human activities were implemented in China to cope with the outbreak of the Coronavirus Disease 2019 (COVID-19), providing an opportunity to investigate the impacts of anthropogenic emissions on air quality. Intensive real-time measurements were made to compare primary emissions and secondary aerosol formation in Xi’an, China before and during the COVID-19 lockdown. Decreases in mass
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Urine cadmium and acute myocardial infarction among never smokers in the Danish Diet, Cancer and Health cohort Environ. Int. (IF 7.577) Pub Date : 2021-02-08 Clara G. Sears; Aslak Harbo Poulsen; Melissa Eliot; Chanelle J. Howe; Katherine A. James; James M. Harrington; Nina Roswall; Kim Overvad; Anne Tjønneland; Ole Raaschou-Nielsen; Gregory A. Wellenius; Jaymie Meliker
Cadmium exposure has been associated with cardiovascular disease. Cigarette smoking is a key source of cadmium exposure and thus a potential confounder in observational studies of environmental cadmium and cardiovascular disease that include tobacco smokers. We leveraged up to 20 years of follow-up in the Danish Diet, Cancer and Health cohort to test the hypothesis that cadmium exposure is associated
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Pathways linking biodiversity to human health: A conceptual framework Environ. Int. (IF 7.577) Pub Date : 2021-02-06 Melissa R. Marselle; Terry Hartig; Daniel T.C. Cox; Siân de Bell; Sonja Knapp; Sarah Lindley; Margarita Triguero-Mas; Katrin Böhning-Gaese; Matthias Braubach; Penny A. Cook; Sjerp de Vries; Anna Heintz-Buschart; Max Hofmann; Katherine N. Irvine; Nadja Kabisch; Franziska Kolek; Roland Kraemer; Iana Markevych; Aletta Bonn
Biodiversity is a cornerstone of human health and well-being. However, while evidence of the contributions of nature to human health is rapidly building, research into how biodiversity relates to human health remains limited in important respects. In particular, a better mechanistic understanding of the range of pathways through which biodiversity can influence human health is needed. These pathways
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Exposure to prenatal phthalate mixtures and neurodevelopment in the Conditions Affecting Neurocognitive Development and Learning in Early childhood (CANDLE) study Environ. Int. (IF 7.577) Pub Date : 2021-02-06 Christine T. Loftus; Nicole R. Bush; Drew B. Day; Yu Ni; Frances A. Tylavsky; Catherine J. Karr; Kurunthachalam Kannan; Emily S. Barrett; Adam A. Szpiro; Sheela Sathyanarayana; Kaja Z. LeWinn
Background Findings from epidemiological studies of prenatal phthalate exposure and child cognitive development are inconsistent. Methods for evaluating mixtures of phthalates, such as weighted quantile sum (WQS) regression, have rarely been applied. We developed a new extension of the WQS method to improve specificity of full-sample analyses and applied it to estimate associations between prenatal
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Ubiquitous atmospheric contamination by tobacco smoke: Nicotine and a new marker for tobacco smoke-derived particulate matter, nicotelline Environ. Int. (IF 7.577) Pub Date : 2021-02-06 Noel J. Aquilina; Christopher M. Havel; Polly Cheung; Roy M. Harrison; Kin-Fai Ho; Neal L. Benowitz; Peyton Jacob III
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European Food Safety Authority open access tools to estimate dietary exposure to food chemicals Environ. Int. (IF 7.577) Pub Date : 2021-02-05 Sofia Ioannidou; Claudia Cascio; Mary B. Gilsenan
The European Food Safety Authority (EFSA) has developed a suite of open access tools to estimate dietary exposure to food-borne chemical hazards. The tools are tailored to several regulatory domains within EFSA’s remit (e.g. food and feed additives, pesticide residues, contaminants and food enzymes) and are intended for use by EFSA experts, industry applicants of regulatory product dossiers, researchers
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Maternal exposure to air pollutants, PCSK9 levels, fetal growth and gestational age – An Italian cohort Environ. Int. (IF 7.577) Pub Date : 2021-02-05 C. Macchi; S. Iodice; N. Persico; L. Ferrari; L. Cantone; M.F. Greco; B. Ischia; E. Dozio; A. Corsini; C.R. Sirtori; M. Ruscica; V. Bollati
Objective Exposure to airborne pollutants during pregnancy appears to be associated with uterine growth restriction and adverse neonatal outcome. Proprotein convertase subtilisin/kexin type (PCSK9), the key modulator of low-density lipoprotein (LDL) metabolism, increases following particulate matter (PM10) exposure. Because maternal cholesterol is required for fetal growth, PCSK9 levels could be used
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The E-Morph Assay: Identification and characterization of environmental chemicals with estrogenic activity based on quantitative changes in cell-cell contact organization of breast cancer cells Environ. Int. (IF 7.577) Pub Date : 2021-02-04 Marja Kornhuber; Sebastian Dunst; Gilbert Schönfelder; Michael Oelgeschläger
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Association between body mass index and arsenic methylation in three studies of Bangladeshi adults and adolescents Environ. Int. (IF 7.577) Pub Date : 2021-02-04 Ahlam Abuawad; Miranda J. Spratlen; Faruque Parvez; Vesna Slavkovich; Vesna Ilievski; Angela M. Lomax-Luu; Roheeni Saxena; Hasan Shahriar; Mohammad Nasir Uddin; Tariqul Islam; Joseph H. Graziano; Ana Navas-Acien; Mary V. Gamble
Background Water-borne arsenic (As) exposure is a global health problem. Once ingested, inorganic As (iAs) is methylated to mono-methyl (MMA) and dimethyl (DMA) arsenicals via one-carbon metabolism (OCM). People with higher relative percentage of MMA (MMA%) in urine (inefficient As methylation), have been shown to have a higher risk of cardiovascular disease and several cancers but appear to have a
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Three decades of trace element sediment contamination: The mining of governmental databases and the need to address hidden sources for clean and healthy seas Environ. Int. (IF 7.577) Pub Date : 2021-02-03 Jonathan Richir; Simon Bray; Tom McAleese; Gordon J. Watson
Trace elements (TEs) frequently contaminate coastal marine sediments with many included in priority chemical lists or control legislation. These, improved waste treatment and increased recycling have fostered the belief that TE pollution is declining. Nevertheless, there is a paucity of long-term robust datasets to support this confidence. By mining UK datasets (100s of sites, 31 years), we assess
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Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013–2016 Environ. Int. (IF 7.577) Pub Date : 2021-02-03 Yuqing Wang; Ruxianguli Aimuzi; Min Nian; Yu Zhang; Kai Luo; Jun Zhang
Background Although an alteration in sex hormones has been linked to perfluoroalkyl substances (PFAS) in premenopausal women and girls, whether such associations exist in postmenopausal women remains uncertain. Objects To examine the associations between serum PFAS concentrations and sex hormone levels in postmenopausal women. Methods Data from the National Health and Nutrition Examination Survey (NHANES)
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Stratification of population in NHANES 2009–2014 based on exposure pattern of lead, cadmium, mercury, and arsenic and their association with cardiovascular, renal and respiratory outcomes Environ. Int. (IF 7.577) Pub Date : 2021-02-03 Xu Yao; Xu Steven Xu; Yaning Yang; Zhi Zhu; Zhao Zhu; Fangbiao Tao; Min Yuan
Background Environmental exposure to toxic metals is an important risk factor to human health. Traditional methods have examined associations between a health endpoint and exposure to heavy metals by either univariate or multiple regression. In the setting of ubiquitous heterogeneous environmental exposures, statistical methods that incorporate mixed exposures are increasingly relevant and may provide
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Printing ink related chemicals, including synthetic phenolic antioxidants, organophosphite antioxidants, and photoinitiators, in printing paper products and implications for human exposure Environ. Int. (IF 7.577) Pub Date : 2021-02-03 Runzeng Liu; Scott A. Mabury
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Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes Environ. Int. (IF 7.577) Pub Date : 2021-02-03 Pahriya Ashrap; Amira Aker; Deborah J. Watkins; Bhramar Mukherjee; Zaira Rosario-Pabón; Carmen M. Vélez-Vega; Akram Alshawabkeh; José F. Cordero; John D. Meeker
Background Metal exposure and psychosocial stress in pregnancy have each been associated with adverse birth outcomes, including preterm birth and low birth weight, but no study has examined the potential interaction between them. Objectives We examined the modifying effect of psychosocial stress on the association between metals and birth outcomes among pregnant women in Puerto Rico Testsite for Exploring
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The effect of occupational exposure to ergonomic risk factors on osteoarthritis of hip or knee and selected other musculoskeletal diseases: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury Environ. Int. (IF 7.577) Pub Date : 2021-02-03 Carel T.J. Hulshof; Frank Pega; Subas Neupane; Claudio Colosio; Joost G. Daams; Prakash Kc; Paul P.F.M. Kuijer; Stefan Mandic-Rajcevic; Federica Masci; Henk F. van der Molen; Clas-Håkan Nygård; Jodi Oakman; Karin I. Proper; Monique H.W. Frings-Dresen
Background The World Health Organization (WHO) and the International Labour Organization (ILO) are developing joint estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of experts. Evidence from mechanistic data suggests that occupational exposure to ergonomic risk factors may cause selected other musculoskeletal diseases, other
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Infant total diet study in France: Exposure to substances migrating from food contact materials Environ. Int. (IF 7.577) Pub Date : 2021-01-30 Véronique Sirot; Gilles Rivière; Stéphane Leconte; Jean-Charles Leblanc; Martine Kolf-Clauw; Paule Vasseur; Jean-Pierre Cravedi; Marion Hulin
A total diet study (TDS) was conducted in France to assess the health risks related to the chemicals in food of non-breastfed children under three years of age (Infant TDS). For the first time, substances coming from food contact materials, such as bisphenol A (BPA), bisphenol A diglycidyl ether (BADGE) and its derivatives, some phthalates, and some ink photoinitiators, were targeted because of growing
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Time-resolved characteristics and production pathways of simulated landfilling N2O emission under different oxygen concentrations Environ. Int. (IF 7.577) Pub Date : 2021-01-30 Chengliang Zhang; Xiaojun Wang; Lai Wei; Boguang Wang; Shaohua Chen
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Inhalation of two Prop 65-listed chemicals within vehicles may be associated with increased cancer risk Environ. Int. (IF 7.577) Pub Date : 2021-01-29 Aalekhya Reddam; David C. Volz
Chemicals are listed on California’s Proposition 65 (Prop 65) for their potential to cause cancer, birth defects or other reproductive harm, and certain chemicals from this list are often detected within interior vehicle dust and air. Therefore, this study examined the potential risk associated with five Prop 65-listed chemicals detected within vehicle interiors: benzene, formaldehyde, di (2-ethylhexyl)
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Understanding global changes in fine-mode aerosols during 2008–2017 using statistical methods and deep learning approach Environ. Int. (IF 7.577) Pub Date : 2021-01-29 Xing Yan; Zhou Zang; Chuanfeng Zhao; Letu Husi
Despite their extremely small size, fine-mode aerosols have significant impacts on the environment, climate, and human health. However, current understandings of global changes in fine-mode aerosols are limited. In this study, we employed newly developed satellite retrieval data and an attentive interpretable deep learning model to explore the status, changes, and association factors of the global
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Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring Environ. Int. (IF 7.577) Pub Date : 2021-01-29 Arthur David; Jade Chaker; Thibaut Léger; Raghad Al-Salhi; Marlene D. Dalgaard; Bjarne Styrishave; Daniel Bury; Holger M. Koch; Bernard Jégou; David M. Kristensen
The analgesic paracetamol/acetaminophen (N-acetyl-4-aminophenol, APAP) is commonly used to relieve pain, fever and malaise. While sales have increased worldwide, a growing body of experimental and epidemiological evidence has suggested APAP as a possible risk factor for various health disorders in humans. To perform internal exposure-based risk assessment, the use of accurate and optimized biomonitoring
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Prenatal phthalate exposures and executive function in preschool children Environ. Int. (IF 7.577) Pub Date : 2021-01-29 Giehae Choi; Gro D. Villanger; Samantha S.M. Drover; Amrit K. Sakhi; Cathrine Thomsen; Rachel C. Nethery; Pål Zeiner; Gun Peggy Knudsen; Ted Reichborn-Kjennerud; Kristin R. Øvergaard; Amy H. Herring; Annette H. Skogan; Guido Biele; Heidi Aase; Stephanie M. Engel
Background Prenatal phthalate exposure has been linked with altered neurodevelopment, including externalizing behaviors and attention-deficit hyperactivity disorder (ADHD). However, the implicated metabolite, neurobehavioral endpoint, and child sex have not always been consistent across studies, possibly due to heterogeneity in neurodevelopmental instruments. The complex set of findings may be synthesized
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Linking pollution and cancer in aquatic environments: A review Environ. Int. (IF 7.577) Pub Date : 2021-01-27 Ciara Baines; Adelaide Lerebours; Frederic Thomas; Jerome Fort; Randel Kreitsberg; Sophie Gentes; Richard Meitern; Lauri Saks; Beata Ujvari; Mathieu Giraudeau; Tuul Sepp
Due to the interconnectedness of aquatic ecosystems through the highly effective marine and atmospheric transport routes, all aquatic ecosystems are potentially vulnerable to pollution. Whilst links between pollution and increased mortality of wild animals have now been firmly established, the next steps should be to focus on specific physiological pathways and pathologies that link pollution to wildlife
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Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort Environ. Int. (IF 7.577) Pub Date : 2021-01-25 Louise Dalsager; Nikolas Christensen; Ulrich Halekoh; Clara Amalie Gade Timmermann; Flemming Nielsen; Henriette Boye Kyhl; Steffen Husby; Philippe Grandjean; Tina Kold Jensen; Helle Raun Andersen
Introduction The immunosuppressive properties of PFASs are widely recognized. Early-life exposure to PFAS has been linked to reduced immune response to childhood vaccinations and increased rates of common infectious diseases, but implications for hospitalizations are unclear. Objectives To investigate the association between maternal serum concentrations of five PFASs during pregnancy and the child’s
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Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans Environ. Int. (IF 7.577) Pub Date : 2021-01-25 Xuehan Zheng; Kun Zhang; Yanbin Zhao; Karl Fent
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Polycyclic aromatic hydrocarbon exposure, oxidative potential in dust, and their relationships to oxidative stress in human body: A case study in the indoor environment of Guangzhou, South China Environ. Int. (IF 7.577) Pub Date : 2021-01-28 Ying-Jie Zhang; Cong Huang; Yan-Shan Lv; She-Xia Ma; Ying Guo; Eddy Y. Zeng
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Cadmium exposure impairs pancreatic β-cell function and exaggerates diabetes by disrupting lipid metabolism Environ. Int. (IF 7.577) Pub Date : 2021-01-25 Huihui Hong; Yudong Xu; Jia Xu; Jingjing Zhang; Yu Xi; Huifeng Pi; Lingling Yang; Zhengping Yu; Qingqian Wu; Zhuoxian Meng; Wei-Shuyi Ruan; Yunzhao Ren; Shuzhen Xu; Yuan-Qiang Lu; Zhou Zhou
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Comparing the long-term responses of soil microbial structures and diversities to polyethylene microplastics in different aggregate fractions Environ. Int. (IF 7.577) Pub Date : 2021-01-24 Junhua Hou; Xiangjian Xu; Hong Yu; Beidou Xi; Wenbing Tan
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Interactions between microplastics, pharmaceuticals and personal care products: Implications for vector transport Environ. Int. (IF 7.577) Pub Date : 2021-01-23 Thilakshani Atugoda; Meththika Vithanage; Hasintha Wijesekara; Nanthi Bolan; Ajit K. Sarmah; Michael S. Bank; Siming You; Yong Sik Ok
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Risk of breast cancer associated with long-term exposure to benzo[a]pyrene (BaP) air pollution: Evidence from the French E3N cohort study Environ. Int. (IF 7.577) Pub Date : 2021-01-24 Amina Amadou; Delphine Praud; Thomas Coudon; Floriane Deygas; Leny Grassot; Elodie Faure; Florian Couvidat; Julien Caudeville; Bertrand Bessagnet; Pietro Salizzoni; John Gulliver; Karen Leffondré; Gianluca Severi; Francesca Romana Mancini; Béatrice Fervers
Background Benzo[a]pyrene (BaP) is an endocrine-disrupting pollutant formed during incomplete combustion of organic materials. It has been recognized as a reproductive and developmental toxicant, however epidemiological evidence of the long-term effect of ambient air BaP on breast cancer (BC) is limited. Thus we evaluated associations between ambient air BaP exposure and risk of BC, overall and according
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Health risks to dietary neonicotinoids are low for Chinese residents based on an analysis of 13 daily-consumed foods Environ. Int. (IF 7.577) Pub Date : 2021-01-24 Kai Cui; Xiaohu Wu; Dongmei Wei; Ying Zhang; Junli Cao; Jun Xu; Fengshou Dong; Xingang Liu; Yongquan Zheng
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Genotoxicity of radiofrequency electromagnetic fields: Protocol for a systematic review of in vitro studies Environ. Int. (IF 7.577) Pub Date : 2021-01-21 Stefania Romeo; Olga Zeni; Anna Sannino; Susanna Lagorio; Mauro Biffoni; Maria Rosaria Scarfì
Background Exposure to radiofrequency electromagnetic fields (RF-EMF, 100 kHz – 300 GHz) emitted by wireless communication technologies is pervasive and ubiquitous. Concern has been raised about possible adverse effects to human health. In 2011 the International Agency for Research on Cancer has classified RF-EMF as possibly carcinogenic to humans, highlighting that the evidence is weak and far from
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Metagenomic analysis of microbiota and antibiotic resistome in household activated carbon drinking water purifiers Environ. Int. (IF 7.577) Pub Date : 2021-01-22 Zhenchao Zhou; Lan Xu; Lin Zhu; Yang Liu; Xinyi Shuai; Zejun Lin; Hong Chen
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Extreme heat and occupational injuries in different climate zones: A systematic review and meta-analysis of epidemiological evidence Environ. Int. (IF 7.577) Pub Date : 2021-01-17 Syeda Hira Fatima; Paul Rothmore; Lynne C. Giles; Blesson M. Varghese; Peng Bi
Background The link between heat exposure and adverse health outcomes in workers is well documented and a growing body of epidemiological evidence from various countries suggests that extreme heat may also contribute to increased risk of occupational injuries (OI). Previously, there have been no comparative reviews assessing the risk of OI due to extreme heat within a wide range of global climate zones
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Beyond bulk δ15N: Combining a suite of stable isotopic measures improves the resolution of the food webs mediating contaminant signals across space, time and communities Environ. Int. (IF 7.577) Pub Date : 2021-01-18 Kyle H. Elliott; Birgit M. Braune; John E. Elliott
Top predators are used as indicators of contaminant trends across space and time. However, signals are integrated over complex food webs, and variation in diet may confound such signals. Trophic position, assessed by bulk δ15N, is widely used to infer the variation in diet relevant to contamination, yet a single variable cannot completely describe complex food webs. Thus, we examined relationships
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Prenatal exposure to organochlorine pesticides and infant growth: A longitudinal study Environ. Int. (IF 7.577) Pub Date : 2021-01-18 Chenhui Yang; Jing Fang; Xiaojie Sun; Wenxin Zhang; Juxiao Li; Xiaomei Chen; Ling Yu; Wei Xia; Shunqing Xu; Zongwei Cai; Yuanyuan Li
Background The association between exposure to organochlorine pesticides (OCPs) and infant growth has been reported contradictorily in previous studies. Few studies have investigated the effects of prenatal exposure to OCPs on infant growth assessed longitudinally at multiple time points. Objectives The purpose of the study was to examine the associations between prenatal exposure to OCPs and infant
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