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Phenylacetyl glutamine (PAGln) enhances cardiomyocyte death after myocardial infarction through β1 adrenergic receptor Environ. Toxicol. (IF 4.5) Pub Date : 2023-12-02 Hang Xu, Na Yang, Bao-Yan Wang, Lin Zhou, Li-Li Xu, Yan Chen, Dong-Jin Wang, Wei-Hong Ge
This study aims to explore the roles of phenylacetyl glutamine (PAGln) on myocardial infarction (MI) pathogenesis. Here, using targeted metabolomics analysis, it was found that the plasma metabolite PAGln was upregulated in coronary artery disease (CAD) patients and MI mice and could be an independent risk factor for CAD. In vivo and in vitro functional experiments revealed that PAGln pretreatment
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Protective effect of chicory and/or artichoke leaves extracts on carbon tetrachloride and gamma-irradiation-induced chronic nephrotoxicity in rats Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-30 Mamdouh M. T. Eassawy, Amel F. M. Ismail
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Cuproptosis-related lncRNAs ovarian cancer: Multi-omics analysis of molecular mechanisms and potential therapeutic targets Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-29 Yichen Wang, Qi Liang, Lu Xu, Jian Xiong, Kefei Gao, Ping Xu, Weiming Huang
Ovarian cancer (OV) is an aggressive malignancy that poses a significant threat to the health and lives of women. Cuproptosis is a newly discovered form of programmed cell death that offers a promising therapeutic target, although its significance in cancer progression remains uncertain. In this study, we established a prognostic model of OV with six cuproptosis-related long non-coding RNAs (lncRNAs)
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Screening of liothyronine network pharmacology role in the treatment of ischemic stroke and molecular mechanism Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-29 Li Yuan, Dongdong Xiao, Rumei Yang, Lei Ge, Yuye Wan, Lianglei Jiang
The present study aimed to elucidate mechanisms of liothyronine on the treatment of ischemic stroke (IS).
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Methyltransferase-like 3-mediated m6A modification of miR-1908-5p contributes to nasopharyngeal carcinoma progression by targeting homeodomain-only protein homeobox Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-29 Yuanhong Zhou, Wei Li
N6-methyladenosine (m6A) modification interacting microRNAs (miRNAs) have been confirmed to participate in nasopharyngeal carcinoma (NPC) progression. This research investigated miR-1908-5p's function and regulatory mechanism in the tumorigenesis of NPC via m6A modification and targeting a key gene.
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Copper and nanocopper toxicity using integrated biomarker response in Pangasianodon hypophthalmus Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Neeraj Kumar, Eric Gismondi, Kotha Sammi Reddy
The current study focused on assessing the toxicological effects of copper (Cu) and copper nanoparticles (Cu-NPs) in acute condition on Pangasianodon hypophthalmus. The median lethal concentration (LC50) for Cu and Cu-NPs were determined as 8.04 and 3.85 mg L−1, respectively. For the subsequent definitive test, varying concentrations were selected: 7.0, 7.5, 8.0, 8.5, and 9.0 mg L−1 for Cu, and 3.0
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Cisplatin induces acute kidney injury by downregulating miR-30e-5p that targets Galnt3 to activate the AMPK signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Weipu Mao, Lei Zhang, Yiduo Wang, Si Sun, Jianping Wu, Jie Sun, Xiangyu Zou, Ming Chen, Guangyuan Zhang
Cisplatin nephrotoxicity is an etiological factor for acute kidney injury (AKI). MicroRNA (miRNA) expression is dysregulated in cisplatin-induced AKI (cAKI) although the underlying mechanisms are unclear. A cAKI model was established by intraperitoneally injecting cisplatin, and key miRNAs were screened using high-throughput miRNA sequencing. The functions of key miRNAs were determined using the cell
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Exploring the role of lactylation-related genes in osteosarcoma: A deep dive into prognostic significance and therapeutic potential Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Jingdong Sun, Yong Li, Rui Chen, Yi Xie, Jie Wei, Binbin Li
Osteosarcoma (OS), notorious for its complex pathogenesis and formidable prognosis, represents a significant medical quandary. This research embarked on a quest to unravel the implications of lactylation-related genes (LRGs) in OS, offering a novel lens through which to interpret its intricacies. A meticulous evaluation of 329 LRGs within the TARGET dataset spotlighted 27 paramount genes, intricately
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Citrate-coated silver nanoparticles loaded with agomelatine provide neuronal therapy in acute cerebral ischemia/reperfusion of rats by inhibiting the oxidative stress, endoplasmic reticulum stress, and P2X7 receptor-mediated inflammasome Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Volkan Gelen, Seçkin Özkanlar, Adem Kara, Ali Yeşildağ
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CircVMP1 promotes glycolysis and disease progression by upregulating HKDC1 in colorectal cancer Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Hong-Yu Chen, Xiang-Nan Li, Lei Yang, Chun-Xiang Ye, Zhi-Lei Chen, Zhen-Jun Wang
Circular RNAs (circRNAs) have been reported to play important roles in cancers. Here, we characterized circVMP1 (hsa_circ_0006508), an important circRNA which promoted glycolysis and disease progression in colorectal cancer (CRC). In this study, we aimed to explore the mechanism by which circVMP1 regulated tumor glycolysis and its related pathways in promoting CRC cell proliferation and metastasis
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MicroRNA-140-3p inhibits proliferation and promotes apoptosis in non-small cell lung cancer by targeting MDIG Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Miaomiao Yu, Yueren Fan, Yihang Zhao, Yu Tang
MicroRNAs (miRNAs) are associated with cancer progression. MiR-140-3p is a tumor suppressor. Nevertheless, its function in non-small cell lung cancer (NSCLC) is unclear.
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Evodiamine attenuates oxidative stress and ferroptosis by inhibiting the MAPK signaling to improve bortezomib-induced peripheral neurotoxicity Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Yunlong Tang, Weiying Gu, Lingling Cheng
Bortezomib (BTZ) is a commonly used antitumor drug, but its peripheral neuropathy side effect poses a limitation on its dosage. Evodiamine (EVO) exhibits various biological activities, including antioxidant, anti-inflammatory, and anticancer effects. The purpose of this investigation is to confirm the impact of EVO on BTZ-induced peripheral neurotoxicity.
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Effect of chronic deltamethrin exposure on brain transcriptome and metabolome of juvenile crucian carp Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Hao Wu, Jinwei Gao, Zhonggui Xie, Min Xie, Rui Song, Xiping Yuan, Yuanan Wu, Dongsheng Ou
Deltamethrin (Del), a widely administered pyrethroid insecticide, has been established as a common contaminant of the freshwater environment and detected in many freshwater ecosystems. In this study, we investigated the changes in brain transcriptome and metabolome of crucian carp after exposure to 0.6 μg/L Del for 28 days. Elevated MDA levels and inhibition of SOD activity indicate damage to the antioxidant
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Genomic and immune landscape in hepatocellular carcinoma: Implications for personalized therapeutics Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-27 Jiaoyun Zheng, Junyan Chen, Shuchao Wang, Dun Yang, Peng Zhou
Hepatocellular carcinoma (HCC) is a globally prevalent malignancy, marked by genetic heterogeneity and intricate tumor microenvironment interactions. In this study, we undertook a detailed single-cell analysis of six active HCC patients, highlighting strong correlations between gene expression levels and cellular characteristics. UMAP clustering revealed seven distinct cell categories with associated
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1-Benzylimidazole attenuates the stemness of breast cancer cells through partially targeting CYP4Z1 Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-23 Hai Qin, Yi Zhou, Hai Liu, Yaqin Yuan, Qianqian Guo, Manqin Yuan, Tao Xi, Yujie Zhang
Cytochrome P450 (CYP) 4Z1 (CYP4Z1) has recently garnered much interest as its expression predicts a poor prognosis and as a oncogene in breast cancer, and overexpressed in other many cancers. We previously showed that CYP4Z1 acts as a promoter of cancer stem cells (CSCs) to facilitate the occurrence and development of breast cancer. Here, RNA sequencing found that 1-benzylimidazole (1-Benzy) held a
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Melatonin ameliorates PM2.5-induced spermatogenesis disorder by preserving H3K9 methylation and SIRT3 Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-23 Jianhui Liu, Moxuan Zhao, Xiaomin Dong, Yue Zhang, Jinglong Xue, Junchao Duan, Zhiwei Sun, Xianqing Zhou
There was a link between exposure to PM2.5 and male infertility. Melatonin has beneficial effects on the male reproductive processes. How PM2.5 caused spermatogenesis disturbance and whether melatonin could prevent PM2.5-induced reproductive toxicity have remained unclear. The results showed that PM2.5 could inhibit the Nrf2-mediated antioxidant pathway and distinctly increase the cell apoptosis in
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The effects of 17α-methyltestosterone on gonadal histology and gene expression along hypothalamic-pituitary-gonadal axis, germ cells, sex determination, and hypothalamus-pituitary-thyroid axis in zebrafish (Danio rerio) Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-23 Minchun Li, Ning Zhang, Yiting Huang, Chang-Gui Pan, Zhongdian Dong, Zhong Lin, Chengyong Li, Yu-Xia Jiang, Yan-Qiu Liang
As a synthetic androgen, 17α-methyltestosterone (MT) is widely used in aquaculture to induce sex reversal and may pose a potential risk to aquatic organisms. This ecological risk has attracted the attention of many scholars, but it is not comprehensive enough. Thus, the adverse effects of MT on zebrafish (Danio rerio) were comprehensively evaluated from gonadal histology, as well as the mRNA expression
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Matrine suppresses hepatocellular carcinoma tumorigenesis by modulating circ_0055976/miR-1179/lactate dehydrogenase A axis Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-23 Xinfeng Chang, Hongwei Li, Zhengchun Huang, Chunhua Song, Zhihua Zhang, Wen Pan
Matrine has been identified to have anticancer activity in hepatocellular carcinoma (HCC). Circ_0055976 was highly expressed in HCC. Here, we investigated the function and relationship of Matrine and circ_0055976 in HCC tumorigenesis.
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ASIC1a contributes to the epithelial–mesenchymal transformation of breast cancer by activating the Ca2+/β-catenin pathway Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-22 Jiawei Wang, Chao Yang, Ruihua Yu, Ming Zhuang, Feng Jiang
Breast cancer is the most common cancer in the world, with metastasis being one of the leading causes of death among patients. The acidic environment of breast cancer tissue promotes tumor cell invasion and migration by inducing epithelial–mesenchymal transformation (EMT) in tumor cells, but the exact mechanisms are not yet fully understood. This study investigated the expression of acid-sensitive
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The identification and functional analysis of CircRNAs in endometrial receptivity of mice with polycystic ovary Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-21 Ziwei Zhao, Dawei Li, Nan Wang, Li Xu, Yujing Weng, Weiqin Zhou, Yanping Pan
The disorders of endometrial receptivity and ovulatory dysfunction are both significant causes of infertility in patients with polycystic ovary syndrome (PCOS). In this study, we investigated the expression profile and functional implications of circular RNAs (circRNAs) in the endometrial receptivity of PCOS-affected mice. Twenty-four female C57BL/6 mice were divided into PCOS and normal control groups
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Anethole mitigates H2O2-induced inflammation in HIG-82 synoviocytes by suppressing the aquaporin 1 expression and activating the protein kinase A pathway Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-21 Tai-Lung Huang, Yu-Chun Chang, Bruce Chi-Kang Tsai, Tung-Sheng Chen, Shih-Wen Kao, Yung-Yun Tsai, Shinn-Zong Lin, Chun-Hsu Yao, Kuan-Ho Lin, Wei-Wen Kuo, Chih-Yang Huang
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting approximately 1% of the global population, with a higher prevalence in women than in men. Chronic inflammation and oxidative stress play pivotal roles in the pathogenesis of RA. Anethole, a prominent compound derived from fennel (Foeniculum vulgare), possesses a spectrum of therapeutic properties, including anti-arthritic, anti-inflammatory
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Selenium reduces acrylamide-induced testicular toxicity in rats by regulating HSD17B1, StAR, and CYP17A1 expression, oxidative stress, inflammation, apoptosis, autophagy, and DNA damage Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-21 Serkan Yildirim, Emin Sengul, Emrah Hicazi Aksu, İrfan Cinar, Volkan Gelen, Samet Tekin, Yusuf Dag
This study investigated the effects of Selenium (Se) on testis toxicity induced by Acrylamide (ACR) in rats. In our study, 50 male adult rats were used, and the rats were divided into five groups; control, ACR, Se0.5 + ACR, Se1 + ACR, and Se1. Se and ACR treatments were applied for 10 days. On the 11th day of the experimental study, intracardiac blood samples from the rats were taken under anesthesia
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Circ_0082878 contributes to prostate cancer progression via the miR-455-3p/WTAP axis Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-21 Pengcheng Zhao, Pengli Han, Yan Ma, Pei Tian, Jing Li
Circ_0082878 has been found to be strongly expressed in prostate cancer (PCa). However, its roles and potential mechanism in PCa have not been investigated. This study aims to clarify it. RNase R digestion method was adopted for verifying the circular structure of circ_0082878. RT-qPCR assay is aimed to detect the expressions of circ_0082878, miR-455-3p and WTAP in PCa tissues and cells. For identifying
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Engrailed 2 serves as a master regulator of the super-enhancer in the TNC gene locus in non-small cell lung cancer Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-21 Yan Li, Jie Jiang, Xiaoyan Wang, Yong Cao, Li Tang, Xueqin Song, Fang Huang, Mingying Li, Feng Chen, Haisu Wan, Sujuan Ye
Engrailed 2 (EN2) is a homeodomain-containing protein that is dysregulated in many types of cancer. However, the role of EN2 in non-small cell lung cancer (NSCLC) and the mechanism underlying its biological function are largely unclear. Here, we showed that EN2 played an oncogenic function in NSCLC and greatly enhanced the malignant phenotype of NSCLC cells. Meanwhile, EN2 was able to boost the expression
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Tanshinone IIA ameliorates cisplatin-induced toxicology and cisplatin resistance via regulating SLC7A11 expression Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-21 Hai Qin, Yaqin Yuan, Manqin Yuan, Siyi Yi, Yonghong Yang, Yujie Zhang
Cisplatin, a potent chemotherapy agent, is highly effective against various cancers but is hindered by resistance and toxicities. This study aims to investigate the roles of SLC7A11, a cystine/glutamate transporter, in cisplatin resistance, and explored Tanshinone IIA as a therapeutic option. Cisplatin reduced SLC7A11 in renal cells, worsening toxicity. Cisplatin-resistant gastric cancer cells show
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TXNIP-NLRP3-GSDMD axis-mediated inflammation and pyroptosis of islet β-cells is involved in cigarette smoke-induced hyperglycemia, which is alleviated by andrographolide Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-21 Wenchao Xu, Hailan Wang, Qian Sun, Tianqi Hua, Jun Bai, Qingbi Zhang, Qizhan Liu, Xinye Ni
Epidemiologic surveys have indicated that cigarette smoking is an important risk factor for diabetes, but its mechanisms remain unclear. Andrographolide, an herb traditionally utilized in medicine, provides anti-inflammatory benefits for various diseases. In the present work, 265 patients with Type 2 diabetes (T2D) were investigated, and male C57BL/6 mice were exposed to cigareete smoke (CS) and/or
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Influence of silver doping on pro-inflammatory and pro-fibrogenic effects of nano-titanium dioxide in murine lung Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-20 Xiaoquan Huang, Congcong Li, Tingting Wei, Lingyue Zou, Na Liu, Changcun Bai, Yongshuai Yao, Zhihui Wang, Binjing Li, Dong Qiao, Yiru Niu, Xiaoli Wang, Meng Tang
Silver is usually loaded on nano-titanium dioxide (TiO2) through photodeposition method to enhance visible-light catalytic functions for environment purification. However, little is known about how the toxicity changes after silver doping and how the physicochemical properties of loaded components affect nanocomposite toxicity. In this study, Ag-TiO2 with different sizes and contents of silver particles
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Radiogenomics uncovers an interplay between angiogenesis and clinical outcomes in bladder cancer Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-17 Chentao Xu, Jincheng Cao, Tianjin Zhou
Precision medicine has become a promising clinical treatment strategy for various cancers, including bladder cancer, where angiogenesis plays a critical role in cancer progression. However, the relationship between angiogenesis, immune cell infiltration, clinical outcomes, chemotherapy, and targeted therapy remains unclear.
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Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-17 Jiadong Chen, Tianxin Zhao, Xiangqin Zheng, Lian Kang, Junke Wang, Yuexin Wei, Yuhao Wu, Lianju Shen, Chunlan Long, Guanghui Wei, Shengde Wu
Di(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is one of the most common plasticizers and is widely used in various plastic products. DEHP induces apoptosis and oxidative stress and has been shown to have androgenic toxicity. However, the methods to combat DEHP-induced testicular damage and the mechanisms involved remain to be elucidated. In the present study, we used melatonin
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MT1G, an emerging ferroptosis-related gene: A novel prognostic biomarker and indicator of immunotherapy sensitivity in prostate cancer Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-16 Bisheng Cheng, Yiming Lai, Hao Huang, Shirong Peng, Chen Tang, Junxiu Chen, Tianlong Luo, Jilin Wu, Haixia He, Qiong Wang, Hai Huang
Prostate cancer is a leading cause of cancer-related deaths in men worldwide. Despite advances in treatment strategies, there is still a need for novel therapeutic targets and approaches. Ferroptosis has emerged as a critical process in the development and progression of several cancers, including prostate cancer (PCA). In this study, we investigate the role of MT1G, a gene implicated in immune responses
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Prognostic impact of lactylation-associated gene modifications in clear cell renal cell carcinoma: Insights into molecular landscape and therapeutic opportunities Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-16 Jinsha Liu, Pang Chen, Jie Zhou, Haoguang Li, Zifeng Pan
Clear cell renal cell carcinoma (ccRCC) stands as a challenging subtype of kidney cancer, frequently complicating patient prognosis due to factors like postsurgical recurrences or late-stage diagnoses. In this study, we employed bioinformatics to investigate lactylation modifications in ccRCC, focusing on the TCGA-KIRC cohort. Out of 328 lactylation-associated genes, 31 emerged as differentially expressed
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Tretinoin (2,4-difluoro-phenyl) triazole activates proapoptotic protein expression and targets NRP2 protein to inhibit esophageal carcinoma cell growth Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-16 Saad H. Alotaibi
The present study investigated the effect of tretinoin (2,4-difluoro-phenyl) triazole (TDFPT) on the growth and proliferation of Kyse-270 and EC9706 esophageal carcinoma cells and explored the underlying mechanism. The results demonstrated that TDFPT treatment of Kyse-270 and EC9706 cells led to a dose-dependent reduction in cell proliferation. Colony formation was significantly (p < .05) reduced in
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Chronic arsenite exposure induced skeletal muscle atrophy by disrupting angiotensin II-melatonin axis in rats Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-15 Wanying Chen, Dapeng Wang, Lu Ma, Fan Wu, Qian Ren, Junyan Tao, Xiong Chen, Aihua Zhang
Arsenic is a well-known environmental toxicant and emerging evidence suggests that arsenic exposure has potential skeletal muscle toxicity; however, the underlying mechanism has not yet been clarified. The aim of this study was to investigate the correlation among adverse effects of subchronic and chronic environmental arsenic exposure on skeletal muscle as well as specific myokines secretion and angiotensin
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The role of PKP1 in tumor progression in melanoma: Analysis of a cell adhesion-related model Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-15 Chao Yue, Wenqin Lian, Zhongru Fan, Haochen Li, Mengying Duan, Lingshan Qin, Xianbin Cao, Jianzhong Peng
The incidence rate of melanoma varies across regions, with Europe, the United States, and Australia having 10–25, 20–30, and 50–60 cases per 1 00 000 people. In China, patients with melanoma exhibit different clinical manifestations, pathogenesis, and outcomes. Current treatments include surgery, adjuvant therapy, and immune checkpoint inhibitors. Nonetheless, complications may arise during treatment
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Allyl isothiocyanate induces DNA damage and inhibits DNA repair-associated proteins in a human gastric cancer cells in vitro Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-15 Yung-Luen Shih, Sheng-Yao Hsu, Kuang-Chi Lai, Fu-Shin Chueh, Yuan-Li Huang, Chao-Lin Kuo, Yung-Liang Chen, Chiung-Ju Chen, Shu-Fen Peng, Wen-Wen Huang, Hsu-Fen Lu
Allyl isothiocyanate (AITC) is abundant in cruciferous vegetables and it present pharmacological activity including anticancer activity in many types of human cancer cells in vitro and in vivo. Currently, no available information to show AITC affecting DNA damage and repair-associated protein expression in human gastric cancer cells. Therefore, in the present studies, we investigated AITC-induced cytotoxic
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Uroprotective effects of berberine and curcumin in cyclophosphamide-induced interstitial cystitis Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-13 Murat Demir, Fikret Altındağ
In this study, it was aimed to investigate the effects of berberine (BER) and curcumin (CUR) in the experimental model of cystitis induced by cyclophosphamide (CYP). A total of 36 Wistar-Albino female rats were used in the study. Rats were randomly divided into six groups (n = 6). Normal control group, dimethyl sulfoxide (DMSO) group, CYP group (75 mg/kg), CYP + BER (75 mg/kg CYP and 50 mg/kg BER)
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Demethylnobiletin ameliorates cerebral ischemia-reperfusion injury in rats through Nrf2/HO-1 signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-13 Dan Huang, Ali Chyadmarzok Al Awad, Chuai Tang, Yunqiang Chen
Demethylnobiletin (DN), with a variety of biological activities, is a polymethoxy-flavanone (PMF) found in citrus. In the present study, we explored the biological activities and potential mechanism of DN to improve cerebral ischemia reperfusion injury (CIRI) in rats, and identified DN as a novel neuroprotective agent for patients with ischemic brain injury.
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Multidimensional progressive single-cell sequencing reveals cell microenvironment composition and cancer heterogeneity in lung cancer Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-13 Hua Chen, Anqi Song, Faisal UL Rehman, Dan Han
Despite substantial advances in cancer biology and treatment, the clinical outcomes of patients with lung cancer remain unsatisfactory. The tumor microenvironment (TME) is a potential target. Using single-cell RNA sequencing, we could distinguish eight distinct cell types in the lung cancer microenvironment, demonstrating substantial intratumoral heterogeneity in 19 different lung cancer tumor samples
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Mechanisms underlying the combination effect of arsenite and high-fat diet on aggravating liver injury in mice Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-13 Zijun Ye, Haiyan Xiong, Liping Huang, Qianyu Zhao, Zhu Xiong, Hongguo Zhang, Wei Zhang
Arsenic (As) is a highly toxic metalloid that can be found in insufficiently purified drinking water and exerts adverse effects on the physiology of living organisms that can negatively affect human health after subchronic exposure, causing several diseases, such as liver damage. A high-fat diet, which is increasing in frequency worldwide, can aggravate hepatic pathology. However, the mechanisms behind
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Resveratrol alleviates fumonisin-induced intestinal cytotoxicity by modulating apoptosis, tight junction, and inflammation in IPEC-J2 porcine intestinal epithelial cells Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-13 Song Yu, Lianpeng Zou, Jiawei Zhao, Yiping Zhu
Fumonisins are common contaminants in the global food and environment, pose a variety of health risks to humans and animals. However, the method of mitigating fumonisin toxicity is still unclear. Resveratrol is a natural compound with antioxidant and anti-inflammatory properties. In this study, the protective effect of resveratrol against fumonisin-induced intestinal toxicity was investigated by the
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Pb(NO3)2 induces cell apoptosis through triggering of reactive oxygen species accumulation and disruption of mitochondrial function via SIRT3/SOD2 pathways Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-10 Hui-Wen Lin, Hsiang-Lin Lee, Ting-Jing Shen, Meng-Ting Ho, Yi-Ju Lee, Inga Wang, Ching-Pin Lin, Yuan-Yen Chang
Lead (Pb) is nonbiodegradable and toxic to the lungs. To investigate the potential mechanisms of Pb-induced reactive oxygen species (ROS) accumulation and cell death in the lungs, human non-small lung carcinoma H460 cells were stimulated with Pb(NO3)2 in this study. The results showed that Pb(NO3)2 stimulation increased cell death by inducing cell apoptosis which showed a reduced Bcl-2 expression and
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Inhibition of miR-578 through SOCS2-dependent manner reverses gefitinib resistance in NSCLC cells Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-10 Bo Yang, Lei Yao, Liankai Yang, Fang Zhao, Wenyan Zhou
Nonsmall-cell lung cancer (NSCLC) has emerged as one of the dreadful lung cancers globally due to its increased mortality rates. Concerning chemotherapy, gefitinib has been employed as an effective first-line treatment drug for NSCLC. Nonetheless, the acquired resistance to gefitinib has remained one of the treatment obstacles of NSCLC, requiring improvement in the therapeutic effect of gefitinib.
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Degradation of AZGP1 suppresses the progression of breast cancer cells via TRIM25 Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-06 Hai Qin, Yaqin Yuan, Manqin Yuan, Haiyan Wang, Yonghong Yang
Alpha-2-glycoprotein 1, zinc-binding (AZGP1) is a secreted protein, which has been shown to be a potential biomarker of cancer progression; however, its roles in breast cancer are still unclear. Currently, we analyzed the online datasets and found that AZGP1 was highly expressed in breast cancer tissues and its expression was negatively correlated with the survival of breast cancer patients. Functional
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6-benzylaminopurine causes endothelial dysfunctions to human umbilical vein endothelial cells and exacerbates atorvastatin-induced cerebral hemorrhage in zebrafish Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-06 Guiyi Gong, Hiotong Kam, Yubin Bai, Wai san Cheang, Shuilong Wu, Xiaoning Cheng, John P. Giesy, Simon Ming-yuen Lee
6-benzylaminopurine (6-BA), a multifunctional plant growth regulator, which is frequently used worldwide to improve qualities of various crops, is an important ingredient in production of “toxic bean sprouts.” Although there is no direct evidence of adverse effects, its hazardous effects, as well as joint toxicity with other chemicals, have received particular attention and aroused furious debate between
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SNHG1, interacting with SND1, contributes to sorafenib resistance of liver cancer cells by increasing m6A-mediated SLC7A11 expression and promoting aerobic glycolysis Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-06 Rong Li, Shunle Li, Lin Shen, Junhui Li, Di Zhang, Jinmin Yu, Lanxuan Huang, Na Liu, Hongwei Lu, Meng Xu
Aerobic glycolysis plays an important role in multidrug resistance of cancer cells. Here, we screened different expressed lncRNAs associated with sorafenib resistance of liver cancer cells, by intersecting the bioinformatics analyses of TCGA and GEO (the GSE62813 dataset) databases. Our results revealed that the 18 upregulated lncRNAs in the intersection are associated with and enriched in metabolism
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Comparative analysis of diisononyl phthalate and di(isononyl)cyclohexane-1,2 dicarboxylate plasticizers in regulation of lipid metabolism in 3T3-L1 cells Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-06 Ceyhun Bereketoglu, Isabel Häggblom, Beste Turanlı, Ajay Pradhan
Diisononyl phthalate (DINP) and di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) are plasticizers introduced to replace previously used phthalate plasticizers in polymeric products. Exposure to DINP and DINCH has been shown to impact lipid metabolism. However, there are limited studies that address the mechanisms of toxicity of these two plasticizers. Here, a comparative toxicity analysis has been
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Perinatal exposure to bisphenol A impairs cognitive function via the gamma-aminobutyric acid signaling pathway in male rat offspring Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-05 Yi Guo, Yuxin Kang, Wenjie Bai, Qiling Liu, Rongqiang Zhang, Yuxin Wang, Chong Wang
Bisphenol A (BPA) is a common synthetic endocrine disruptor that can be utilized in the fabrication of materials such as polycarbonates and epoxy resins. Numerous studies have linked BPA to learning and memory problems, although the precise mechanism remains unknown. Gamma-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the vertebrate central nervous system, and it is intimately
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Hsa_circ_0001707 regulates endothelial-mesenchymal transition in esophageal squamous cell carcinoma via miR-203a-3p/Snail2 pathway Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-03 Han Gao, Mingjun Sun, Zhikui Gao, Jing Song, Derong Tang, Ran Liu
Esophageal squamous cell carcinoma (ESCC) is a malignant tumor with high mortality and poor prognosis. Despite intensive research focused on tumor suppression, the 5-year survival rate of ESCC is lower than 15%. Therefore, investigate fundamental mechanisms involved in ESCC is on-demand crucial for diagnostics and developing targeted therapeutic drugs. Circular RNAs (circRNAs), as an emerging class
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Demethoxymurrapanine, an indole-naphthoquinone alkaloid, inhibits the proliferation of oral cancer cells without major side effects on normal cells Environ. Toxicol. (IF 4.5) Pub Date : 2023-11-03 Ya-Ting Chuang, Ching-Yu Yen, Jun-Ping Shiau, Fang-Rong Chang, Chang-Yih Duh, Ping-Jyun Sung, Kuan-Liang Chen, Yi-Hong Tsai, Jen-Yang Tang, Jiiang-Huei Jeng, Jyh-Horng Sheu, Hsueh-Wei Chang
Antioral cancer drugs need a greater antiproliferative impact on cancer than on normal cells. Demethoxymurrapanine (DEMU) inhibits proliferation in several cancer cells, but an in-depth investigation was necessary. This study evaluated the proliferation-modulating effects of DEMU, focusing on oral cancer and normal cells. DEMU (0, 2, 3, and 4 μg/mL) at 48 h treatments inhibited the proliferation of
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Assessing the mechanisms and adjunctive therapy for arsenic-induced liver injury in rats Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-30 Yuyan Xu, Qibing Zeng, Aihua Zhang
Environmental arsenic exposure is a significant global public health concern. Previous studies have demonstrated the association between arsenic-induced liver injury and oxidative stress as well as ferroptosis. However, the knowledge of the interactions among these mechanisms remains limited. Moreover, there is a lack of research on potential therapeutic interventions for liver injury resulting from
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Dieckol prevents prostate cancer cell proliferation by transcriptionally attenuating JAK/STAT3 signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-27 Vimala Karuppaiya, Asaikkutti Annamalai, Shanthi Krishnamurthy, Kannan Soundarapandian
This study delved at how the natural substance dieckol (DCL) prevents prostate cancerous cells from proliferating and migrating by blocking the JAK/STAT3 signaling pathway in PC-3 cells. For numerous tests, the cells were treated to DCL at a range of concentrations (0–20 μM) for 24 h. DCL mediated cytotoxicity was analyzed by MTT assay. To evaluate ROS, DCFH-DA staining was employed. Dual (AO/EtBr)
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The single-cell evolution trajectory presented different hypoxia heterogeneity to reveal the carcinogenesis of genes in clear cell renal cell carcinoma: Based on multiple omics and real experimental verification Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-27 Baoluo Ma, Linghui Qin, Zhou Sun, Jingyu Wang, Lisa Jia Tran, Jing Zhang, Fangdie Ye, Yan Liu, Min Chen
Clear cell renal cell carcinoma (ccRCC) is the most prevalent and aggressive subtype of renal cell carcinoma, originating from renal tubular epithelial cells in the kidney. Hypoxia proves to be a feature commonly observed in solid tumors, leading to increased resistance to treatment and tumor progression.
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Airborne magnetite nanoparticles induced early vascular pathologies by disrupting lipid metabolism under high-fat dietary patterns Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-20 Jingxu Zhang, Hongyan Yu, Ruonan Pan, Gan Miao, Yu Wang, Ziyuan Li, Haiyi Yu, Lin Lu, Xiaoting Jin
Magnetite nanoparticles (MNPs) have been extensively detected in the atmospheric environment and implicated as a prominent threat to atherosclerosis, a chronic vascular inflammatory disease. Due to globalization and economic development, the dramatic shift in diet from traditional to high-fat dietary patterns aggravated atherosclerosis progression induced by environmental factors. However, limited
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Ubiquitin-specific peptidase 10 attenuates the ferroptosis to promote thyroid cancer malignancy by facilitating GPX4 via elevating SIRT6 Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-20 Feng Lian, Dandan Dong, Jiaxi Pu, Guanghua Yang, Jing Yang, Shaofei Yang, Yijie Wang, Bin Zhao, Minhao Lu
Ubiquitin-specific peptidase 10 (USP10) has been found to have oncogenic activity in several human tumors. This study first revealed the exact function of USP10 on the progression of thyroid cancer (THCA) by researching its effect on the ferroptosis.
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Nano-selenium alleviates cadmium-induced neurotoxicity in cerebrum via inhibiting gap junction protein connexin 43 phosphorylation Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-20 Ya-Ru Xu, Milton Talukder, Chen-Xi Li, Ying-Xin Zhao, Cong Zhang, Jing Ge, Jin-Long Li
Cadmium (Cd) as a ubiquitous toxic heavy metal is reported to affect the nervous system. Selenium (Se) has been shown to have antagonistic effects against heavy metal toxicity. In addition, it shows potential antioxidant and anti-inflammatory properties. Thus, the purpose of this study was to determine the possible mechanism of brain injury after high Cd exposure and the mitigation of Nano-selenium
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Effect and molecular mechanism of Sulforaphane alleviates brain damage caused by acute carbon monoxide poisoning:Network pharmacology analysis, molecular docking, and experimental evidence Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-20 Ao-Chun Yue, Xu-Dong Zhou, Hui-Ping Song, Xu-Han Liu, Ming-Jun Bi, Wei Han, Qin Li
Sulforaphane (SFN) has attracted much attention due to its ability on antioxidant, anti-inflammatory, and anti-apoptotic properties, while its functional targets and underlying mechanism of action on brain injury caused by acute carbon monoxide poisoning (ACOP) have not been fully elucidated. Herein, we used a systematic network pharmacology approach to explore the mechanism of SFN in the treatment
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Corosolic acid inhibits metastatic response of human renal cell carcinoma cells by modulating ERK/MMP2 signaling Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-20 Tsai-Kun Wu, Tung-Wei Hung, Yong-Syuan Chen, Ying-Ru Pan, Yi-Hsien Hsieh, Jen-Pi Tsai
Corosolic acid (CA), a plant-derived pentacyclic triterpenoid, has potent anti-inflammatory, anti-metabolic, and anti-neoplastic actions against a variety of human cancers. However, the specific mechanism by which CA inhibits the progression of renal cell carcinoma (RCC) is yet unclear. We found that CA (≤8 μM) had no influence on either the growth or viability of RCC cell lines (786-O, ACHN, and Caki-1)
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Escin-sorafenib synergy up-regulates LC3-II and p62 to induce apoptosis in hepatocellular carcinoma cells Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-18 Yusuf Hussain, Jyoti Singh, Abha Meena, Rohit Anthony Sinha, Suaib Luqman
Hepatocellular carcinoma (HCC) is a common solid cancer and the leading cause of cancer deaths worldwide. Sorafenib is the first drug used to treat HCC but its effectiveness needs to be improved, and it is important to find ways to treat cancer that combine sorafenib with other drugs. Synergistic therapies lower effective drug doses and side effects while enhancing the anticancer effect.
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Arsenic-induced IGF-1 signaling impairment and neurite shortening: The protective roles of IGF-1 through the PI3K/Akt axis Environ. Toxicol. (IF 4.5) Pub Date : 2023-10-18 Churaibhon Wisessaowapak, Apichaya Niyomchan, Daranee Visitnonthachai, Naphada Leelaprachakul, Piyajit Watcharasit, Jutamaad Satayavivad
We recently reported that arsenic caused insulin resistance in differentiated human neuroblastoma SH-SY5Y cells. Herein, we further investigated the effects of sodium arsenite on IGF-1 signaling, which shares downstream signaling with insulin. A time-course experiment revealed that sodium arsenite began to decrease IGF-1-stimulated Akt phosphorylation on Day 3 after treatment, indicating that prolonged