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Integrated analysis of multi‐omics data on epigenetic changes caused by combined exposure to environmental hazards Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-13 So Yeon Yu; Eun Jung Koh; Seung Hwan Kim; So Yul Lee; Ji Su Lee; Sang Wook Son; Seung Yong Hwang
Humans are easily exposed to environmentally hazardous factors in industrial sites or daily life. In addition, exposure to various substances and not just one harmful substance is common. However, research on the effects of combined exposure on humans is limited. Therefore, this study examined the effects of combined exposure to volatile organic compounds (VOCs) on the human body. We separated 193
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Puerarin prevents cadmium‐induced disorder of testicular lactic acid metabolism in rats by activating 5′ AMP‐activated protein kinase (AMPK)/sirtuin 1 (SIRT1) signaling pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-06 Wenxuan Dong; Kanglei Zhang; Gang Liu; Yun Tan; Hui Zou; Yan Yuan; Jianhong Gu; Ruilong Song; Jiaqiao Zhu; Zongping Liu
Cadmium (Cd) interferes with the function of the male reproductive system; however, the molecular mechanism is poorly understood. This study aimed to evaluate the effect of puerarin (PU) on Cd‐induced testicular lactic acid metabolism disorder. Weaning male Sprague–Dawley rats were pre‐fed for 7 days, weighed, and randomly divided into four groups: Control group, CdAc2 group, CdAc2 + PU group, PU group
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The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-06 Jialiu Wei; Xifeng Wang; Qian Liu; Na Zhou; Shuxiang Zhu; Zekang Li; Xiaoli Li; Jinpeng Yao; Lianshuang Zhang
The extensive existing of microplastics (MPs) in the ecosystem have increased considerable attention concerning their potential adverse effects, the toxicities and the underlying mechanism of MPs are still scarce. To explore the effect of MPs on cardiac tissue in Wistar rats and unravel the mechanism of pyroptosis and oxidative stress in the process of cardiomyocytes injury, 32 male Wister rats were
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Dichloroacetate attenuates the stemness of hepatocellular carcinoma cells via promoting nucleus‐cytoplasm translocation of YAP Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-06 Duanyu Su; Zhian Lin
The antitumor effects of dichloroacetate (DCA) have been widely explored, however, its roles in hepatocellular carcinoma (HCC) progression are still unclear. In the current work, we found that DCA had little effects on HCC cell viability, but could attenuate the stemness of HCC cells, which is evident by decreasing the tumor sphere‐formation ability, ALDH activity and the expression of stemness critical
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Cyclopiazonic acid induced p53‐dependent apoptosis in the testis of mice: Another male related risk factor of infertility Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-05 Farzaneh Bonyadi; Shapor Hasanzadeh; Hassan Malekinejad
Cyclopiazonic acid (CPA) is an indole tetrameric acid mycotoxin. This study carried out to investigate the potential effects of CPA on male reproductive system. In the current study, 40 adult male mice were divided into five groups (n = 8). The control group did not expose to CPA, while animals in vehicle‐received group; received the CPA‐solvent (0.05% dimethyl sulfoxide) and the animals of third,
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Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 through pro‐oxidant stimulus Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-04 Khairy A. Ibrahim; Hala A. Abdelgaid; Mohamed Ali El‐Desouky; Abdelgawad Ali Fahmi; Mohamed M. Abdel‐Daim
Gestational exposure to environmental pollutants can induce oxidative injury and apoptosis since the fetal organs are sensitively vulnerable to these chemicals. In this work, we have investigated the renal anti‐apoptotic efficiency of linseed (LS) against the oxidative stress‐mediated upregulation of the fetal apoptosis‐related genes following the prenatal intoxication with diesel nanoparticles (DNPs)
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The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-04 Stéphane Zingue; Julia Cisilotto; Robinson Charly Mbe Fogang; Edwige Nana Tchoupang; Derek Tantoh Ndinteh; Nestor‐Fernand Tchuenguem Fohouo; Dieudonné Njamen; Tânia Beatriz Creczynski‐Pasa
Identification of novel natural treatment to combat cancer is a current need. This study was aimed at assessing the anticancer effects of ethanol‐extracted Cameroonian propolis (EEP). The antitumor effect of EPP was evaluated in vitro by measuring; cell viability, cell cycle, cell death mechanism, cell migration/invasion, reactive oxygen species (ROS), mitochondrial potential (ΔΨm), caspase activity
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Hydromethanolic root and aerial part extracts from Echium arenarium Guss suppress proliferation and induce apoptosis of multiple myeloma cells through mitochondrial pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-04 Inès Limam; Fatma Ben Aissa‐Fennira; Rim Essid; Ahlem Chahbi; Sarra Kefi; Khaoula Mkadmini; Salem Elkahoui; Mohamed Abdelkarim
Echium arenarium Guss is a Mediterranean plant traditionally used in healing skin wound and it was reported exhibiting potent antioxidant, antibacterial, and antiparasitic activities. However, antitumoral activities of this plant have not yet been explored. Here we investigated for the first time, root (EARE) and aerial part (EAAPE) extracts of E. arenarium Guss to examine cytotoxicity and apoptosis
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Ras/Raf/MEK/ERK pathway axis mediated neurotoxicity induced by high‐risk pesticide residue‐Avermectin Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-31 Ting Zhu; Xu Liu; Jian Song; Dong Li; Xiao‐Jing Pang; Sheng‐Hui Wang; Qing‐Rong Li; Dong‐Jun Fu; Sai‐Yang Zhang; Han‐Zhong Xie
Pesticide residues have become a healthy threaten of human beings. Among the pesticides, many of them have neurotoxicity. Extracellular Regulated Protein Kinases (ERK) pathway is an important signaling pathway that regulates a variety of downstream progress. In this work, peach (PRUNUS persica) and cherry (PRUNUS cerasus) were sampled from over 300 plantations in China and assessed for the residue
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Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-31 Mathan Ramesh; Madhavan Sujitha; Pottanthara Ashokan Anila; Zongming Ren; Rama Krishnan Poopal
Ciprofloxacin drugs are a second‐generation fluoroquinolone highly prescribed medication against various bacterial infections in human and aquaculture practices. These drugs are chemically designed to persist in the body long enough to achieve target objectives. Extensive usage has resulted in ciprofloxacin becoming a ubiquitous contaminant in the environment. Unfortunately, the ecotoxicological profiles
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6,8‐Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53 Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-31 Yong Jun Choi; Jongsung Lee; Sang Hoon Ha; Han Ki Lee; Heui Min Lim; Seon‐Hak Yu; Chang Min Lee; Myeong Jin Nam; Yung‐Hun Yang; Kyungmoon Park; Youn Soo Choi; Kyu Yun Jang; See‐Hyoung Park
6,8‐Diprenylorobol is a natural compound mainly found in Glycyrrhiza uralensis fisch and Maclura tricuspidata, which has been used traditionally as food and medicine in Asia. So far, the antiproliferative effect of 6,8‐diprenylorobol has not been studied yet in colon cancer. In this study, we aimed to evaluate the antiproliferative effects of 6,8‐diprenylorobol in LoVo and HCT15, two kinds of human
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The role of H3K9me2‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba extract intervention Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-30 Xuejiao Ding; Anliu Zhang; Changzhe Li; Lu Ma; Shunfang Tang; Qi Wang; Guanghong Yang; Jun Li
Arsenic is an established human carcinogen that can induce DNA damage; however, the precise mechanism remains unknown. Histone modification is of great significance in chemical toxicity and carcinogenesis. To investigate the role of histone H3K9me2 in arsenic‐induced DNA damage, HaCaT cells were exposed to sodium arsenite in this study, and the results showed that the enrichment level of H3K9me2 at
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Effects of benzo(a)pyrene at environmentally relevant doses on embryo‐fetal development in rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-22 Suyane da Silva Moreira; Leonardo Cesar de Lima Inocêncio; Bárbara Campos Jorge; Ana Carolina Casali Reis; Hamilton Hisano; Arielle Cristina Arena
Studies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of
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Genistein enhances the effects of L‐asparaginase on inducing cell apoptosis in human leukemia cancer HL‐60 cells Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-21 Yin‐Chen Hsiao; Fu‐Shin Chueh; Yi‐Shih Ma; Jin‐Cherng Lien; Te‐Chun Hsia; Wen‐Wen Huang; Yu‐Cheng Chou; Po‐Yuan Chen; Jing‐Gung Chung; Hung‐Yi Chen; Kuo‐Ching Liu
Genistein (GEN) has been shown to induce apoptotic cell death in various human cancer cells. L‐asparaginase (Asp), a clinical drug for leukemia, has been shown to induce cell apoptosis in leukemia cells. No available information concerning GEN combined with Asp increased the cell apoptosis compared to GEN or Asp treatment alone. The objective of this study is to evaluate the anti‐leukemia activity
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Chemopreventive effect of dieckol against 7,12‐dimethylbenz(a)anthracene induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-21 Wenming Xiao; Hongyan Liu; Ying Lei; Huawei Gao; Tahani Awad Alahmadi; Haitao Peng; Wei Chen
Skin cancer is the commonly found type, which contributes to 40% of whole cancer incidences worldwide. Dieckol is an active compound occurs in the marine algae with many biological benefits. In this exploration, we intended to investigate the therapeutic potency of dieckol against the 7,12‐dimethylbenz(a)anthracene (DMBA)‐triggered skin carcinogenesis in mice. The skin cancer was stimulated to the
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Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-19 Bolin Wu; Chengyou Yang; Yuefeng Fang; Weilong Ding; Yuqing Zhang
Long noncoding RNA (lncRNA) DUXAP10 has been shown to act as an oncogene in various tumors; however, its roles in glioma progression have never been established. Here, we show that DUXAP10 is overexpressed in glioma tissues and cells. Loss of function experiments reveal that DUXAP10 knockdown has little effects on glioma cell viability, but significantly reduces the stemness of glioma cells, which
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Poria cocos (Fuling) targets TGFβ/Smad7 associated collagen accumulation and enhances Nrf2‐antioxidant mechanism to exert anti‐skin aging effects in human dermal fibroblasts Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-18 Chien‐Liang Fang; Catherine Reena Paul; Cecilia Hsuan Day; Ruey‐Lin Chang; Chia‐Hua Kuo; Tsung‐Jung Ho; Dennis Jine‐Yuan Hsieh; Vijaya Padma Viswanadha; Wei‐Wen Kuo; Chih‐Yang Huang
Oxidative stress is a major cause of aging related skin injuries. Hydrogen peroxide related ROS accumulation triggers increase in matrix metalloproteinases and elevated collagen degradation, which is a characteristic of skin aging. In this study, we investigated the protective effect of Poria cocos, used widely in the treatment of inflammatory diseases, against H2O2 induced oxidative stress. The aqueous
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Nimodipine attenuates dibutyl phthalate‐induced learning and memory impairment in kun ming mice: An in vivo study based on bioinformatics analysis Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-18 Biao Yan; Ping Ma; Shaohui Chen; Hongguo Cheng; Min Tang; Yanling Sun; Xu Yang; Yang Wu; Menglin Cheng
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Dieckol alleviates dextran sulfate sodium‐induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO‐1 signaling pathway Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-17 Xiaoyan Zhu; Yuanhua Sun; Ying Zhang; Xinyou Su; Changqin Luo; Saud Alarifi; Hui Yang
Ulcerative colitis (UC) is the major type of inflammatory ailment with elevated prevalence worldwide. Dieckol (DEK) is a phlorotannin that is extensively found in marine algae and has been found to have different pharmacological properties. Nevertheless, the impact of DEK in UC has not been investigated earlier. Therefore, we appraised DEK's function in dextran sulfate sodium (DSS)‐induced UC in the
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Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di‐N‐butyl‐phthalate Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-17 Xiaolei Xu; Zhenting Qu; Honghao Qian; Zhongming Li; Xiuling Sun; Xinrui Zhao; Huan Li
With the aggravation of environmental pollution, the incidence of infertility is increasing. Ginsenoside Rg1 is a monomer component extracted from Panax ginseng. It has been found that Ginsenoside Rg1 is able to prevent premature ovarian failure and delay testicular senescence. Therefore, we speculate Ginsenoside Rg1 may have great potential to prevent and treat infertility. The aim of this work is
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Kirenol inhibited the cell survival and induced apoptosis in human thyroid cancer cells by altering PI3K/AKT and MAP kinase signaling pathways Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-17 Yulong Wang; Jia Xu; Saud Alarifi; Huanjun Wang
The thyroid cancer, especially papillary thyroid cancers are very common among population with high intake of iodine or iodine uptake. Even though several treatment options are available, there is still complication and side effects are still persistent. The role of signaling molecules in cancer signaling is very vast and their significance in progression of disease was increasing which leads to mortality
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Biochemical study on the protective effect of curcumin on acetaminophen and gamma‐irradiation induced hepatic toxicity in rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-17 Mamdouh M. T. Eassawy; Asmaa A. Salem; Amel F. M. Ismail
Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID‐19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the current study represents that treatment of rats with either APAP‐overdose, or gamma‐irradiation
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Dual down‐regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-16 Tzu‐Chao Chuang; Kuohui Wu; Ying‐Yu Lin; Han‐Peng Kuo; Ming‐Ching Kao; Vinchi Wang; Shih‐Chung Hsu; Shou‐Lun Lee
The overexpression of EGFR and/or ErbB2 occurs frequently in ovarian cancers and is associated with poor prognosis. The purpose of this study was to examine the anticancer effects and molecular mechanisms of berberine on human ovarian cancer cells with different levels of EGFR and/or ErbB2. We found that berberine reduced the motility and invasiveness of ovarian cancer cells. Berberine depleted both
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Butein induces cellular senescence through reactive oxygen species‐mediated p53 activation in osteosarcoma U‐2 OS cells Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-16 Yung‐Ken Hsu; Hsuan‐Ying Chen; Chia‐Chieh Wu; Ying‐Chih Huang; Cheng‐Pu Hsieh; Po‐Feng Su; Yi‐Fu Huang
Butein is a flavonoid isolated from various medicinal plants. It is known to have different biological activities including anti‐inflammation, anti‐adipogenesis, and anti‐angiogenesis. In the study, we demonstrated the anti‐proliferative effect of butein in human osteosarcoma U‐2 OS cells. Our data showed that butein significantly suppressed the viability and colony formation ability of U‐2 OS cells
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Seven traditional Chinese herbal extracts fermented by Lactobacillus rhamnosus provide anti‐pigmentation effects by regulating the CREB/MITF/tyrosinase pathway Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-14 Chih‐Chu Ho; Shang‐Chuan Ng; Ho‐Lin Chuang; Jia‐Yi Chen; Su‐Ying Wen; Chia‐Hua Kuo; B. Mahalakshmi; Quoc‐Vu Le; Chih‐Yang Huang; Wei‐Wen Kuo
Skin pigmentation is resulted from several processes, such as melanin synthesis transportation and abnormal melanin accumulation in keratinocytes. Various studies have suggested that seven traditional Chinese herbal extracts from Atractylodes macrocephala, Paeonia lactiflora, Bletilla striata, Poria cocos, Dictamnus dasycarpus, Ampelopsis japonica and Tribulus terrestris (which we collectively named
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MiRNA‐429 alleviates ketamine‐induced neurotoxicity through targeting BAG5 Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-07 Xiaodi Fan; Wenchao Bian; Meichen Liu; Jinjie Li; Yunyun Wang
Ketamine is a kind of anesthetic broadly applied in clinic. However, growing evidence has indicated that ketamine may induce neurotoxicity. Previous studies showed that mircoRNAs (miRNAs) participate in various aspects of biological regulations. In our work, we aimed to reveal the role of miR‐429 in ketamine‐induced neurotoxicity. The qRT‐PCR was used to measure the miR‐429 levels in ketamine‐treated
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Nimbolide induces cell death in T lymphoma cells: Implication of altered apoptosis and glucose metabolism Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-04 Pradip Kumar Jaiswara; Vishal Kumar Gupta; Pratishtha Sonker; Shiv Govind Rawat; Rajan Kumar Tiwari; Chandramani Pathak; Santosh Kumar; Ajay Kumar
Nimbolide is a tetranortriterpenoid derived from the leaves and flowers of Azadirachta indica (Neem). It exhibits anticancer activity against a variety of cancers by modulating various crucial features, including cell proliferation, apoptosis, and invasion and metastasis. More importantly, the cytotoxic effect of nimbolide has also been observed against T cell lymphoma, but the underlying mechanisms
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Carboxy terminus of HSP70‐interacting protein (CHIP) attenuates the stemness of thyroid cancer cells through decreasing OCT4 protein stability Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-03 Ying Xu; Gang Xu; Huimin Dang; Wei Qu; Dan Chang; Xin He; Minmin Li; Qian Wang
Cancer cell stemness results in the occurrence and progression of tumors and Oct4 (octamer‐binding transcription factor) has been confirmed to be a critical contributor and marker of cancer cell stemness. Here, we aimed to explore the underlying mechanisms contributing to Oct4 protein stability, which is necessary for thyroid cancer (TC) cell stemness. We indicated that carboxy terminus of HSP70‐interacting
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Nootkatone improves anxiety‐ and depression‐like behavior by targeting hyperammonemia‐induced oxidative stress in D‐galactosamine model of liver injury Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-03 Tingxu Yan; Fuyuan Li; Weilin Xiong; Bo Wu; Feng Xiao; Bosai He; Ying Jia
Acute or chronic liver injury is closely related to hyperammonemia, which will result in oxidative stress and damage to nerve cells, and these factors are vital to the development of anxiety and depression. In this study, the effect of Nootkatone (NKT) on the anxiety‐ and depression‐like behavioral changes in mice induced by liver injury was investigated. Liver injury was induced by D‐galactosamine
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Extracts of Jasminum sambac flowers fermented by Lactobacillus rhamnosus inhibit H2O2‐ and UVB‐induced aging in human dermal fibroblasts Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-03 Chih‐Chu Ho; Shang‐Chuan Ng; Ho‐Lin Chuang; Su‐Ying Wen; Chia‐Hua Kuo; B. Mahalakshmi; Chih‐Yang Huang; Wei‐Wen Kuo
Ultraviolet (UV) irradiation is a crucial factor that leads to skin photoaging and results in increased DNA damage, oxidative stress, and collagen degradation. Jasmine flowers have been utilized as a traditional medicine in Asia to treat various diseases, including dermatitis, diarrhea, and fever. Furthermore, the fermented broth of Lactobacillus rhamnosus has been reported to exert protective effects
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Silica nanoparticles induce mitochondrial pathway‐dependent apoptosis by activating unfolded protein response in human neuroblastoma cells Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-03 Shanshan Hou; Xiayu Zhang; Haiying Du; Xiaofan Ning; Hao Wu; Chunrui Li; Yuxin Liu; Zhiwei Sun; Zhongjun Du; Minghua Jin
The application of silica nanoparticles (SiNPs) in areas of agriculture and medicine has raised great concerns for the potential adverse effects of SiNPs. The increasing toxicological studies focused mainly on the lung and cardiovascular system, but the adverse effects of SiNPs on nervous system have not been well explored. This study aimed to evaluate the role and mechanism of unfolded protein reaction
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Early embryonic exposure to chlorpyrifos‐cypermethrin combination induces pattern deficits in the heart of domestic hen Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-03 Urja Verma; Kashmira Khaire; Isha Desai; Shashikant Sharma; Suresh Balakrishnan
Exposure to chlorpyrifos‐cypermethrin combination during early development resulted in defective looping and ventricular noncompaction of heart in domestic chicken. The study was extended to elucidate the molecular basis of this novel observation. The primary culture of chicken embryonic heart cells showed a concentration‐dependent loss of viability when challenged with this combination of technical‐grade
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Protective effect of hesperidin against N,N′‐dimethylhydrazine induced oxidative stress, inflammation, and apoptotic response in the colon of Wistar rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-02 Shekh Mohammad Afzal; Abul Vafa; Summya Rashid; Preeti Barnwal; Ayaz Shahid; Alpa Shree; Johirul Islam; Nemat Ali; Sarwat Sultana
Hesperidin (HD), a citrus bioflavonoid possesses a variety of biological activities including antioxidant, anti‐inflammatory, anti‐apoptotic and anti‐carcinogenic properties. In the present study, we investigated the effect of HD treatment on N,N′‐dimethylhydrazine (DMH) induced oxidative stress, inflammation, apoptosis and goblet cell disintegration in the colon of Wistar rats. Administration of HD
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The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-01 Junxia Shi; Chenyu Liu; Mingyue Chen; Jinhui Yan; Chonggang Wang; Zhenghong Zuo; Chengyong He
Numerous studies have shown that endocrine‐disrupting chemicals are one of the important pathogenic factors in women with polycystic ovary syndrome. Our previous study has revealed that bisphenol A (BPA) can cause steroid hormone imbalance, polycystic ovary, and estrus cycle disorder. In this study, we aimed to explore the effect of BPA, a typical environmental estrogen, on the synthesis of steroid
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Biofabricated zinc oxide nanoparticles impair cognitive function via modulating oxidative stress and acetylcholinesterase level in mice Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-28 Ekta Yadav; Pankajkumar Yadav
Current work was designed to explore the effect of ZnO nanoparticles (ZnONP) biofabricated by using Trianthema portulacastrum (TP) leaves extract on mice brain hippocampus. ZnO nanoparticles of TP leaves (ZnOTP) were synthesized by co‐precipitation method and further characterized by using various techniques such as UV‐Vis spectrophotometer, Field Emission Scanning Electron Microscopy (FESEM), Fourier
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Histological and transcriptional effects of androstenedione in adult zebrafish (Danio rerio) Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-28 Yan‐Qiu Liang; Chang‐Gui Pan; Linchun Xie; Jialiang Huo; Jiahao Yang; Tianhong Lan; Zhongdian Dong; Meina Duan
As a natural androgen, androstenedione (AED) may pose potential risks to aquatic organisms due to its ubiquitousness in aquatic environments. Here we assessed the adverse effects of AED on histology of gonads, as well as mRNA expression levels of 34 genes concerned with hypothalamic‐pituitary‐gonadal (HPG) axis, germ‐cell differentiation and sex differentiation in zebrafish (Danio rerio). Adult zebrafish
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Ginsenoside Rb1 protects porcine oocytes against methylglyoxal damage thus it improves the quality of parthenogenetic activation and in vitro fertilization embryos Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-25 Zhao‐Bo Luo; Mei‐Fu Xuan; Sheng‐Zhong Han; Zhou‐Yan Li; Nasar Khan; Biao‐Hu Quan; Xi‐Jun Yin; Jin‐Dan Kang
Panax ginseng, a functional food, has been widely used as an edible nourishment and medicinal supplement. Ginsenoside Rb1 is a major bioactive ingredient of ginseng, which shows very specific anti‐apoptosis and anti‐oxidant activities. Methylglyoxal (MGO) is one of intermediate products of glucose metabolism, which is absorbed easily from high sugar foods or carbonated beverages. It may involve in
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Reproductive organ dysfunction and gene expression after orally administration of ZnO nanoparticles in murine Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-25 Huijuan Kuang; Wanyi Zhang; Lin Yang; Zoraida P. Aguilar; Hengyi Xu
ZnO nanoparticles (NPs) are among the most manufactured nanoparticles in the consumer products, industries, and researches. An increasing body of evidence indicated that ZnO NPs show toxicological effects in vivo. Sex differences in the toxicity of ZnO NPs are not clear, thus the aim of this study was to investigate the effects of ZnO NPs on the female and male reproductive organs (uterus, ovary and
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N‐acetylcysteine reduced the immunotoxicity effects induced in vitro by azoxystrobin and iprodione fungicides in mice Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-23 Sahar Naasri; Imen Helali; Majoub Aouni; Maha Mastouri; Hedi Harizi
Azoxystrobin (AZO) and Iprodione (IPR) fungicides are extensively used worldwide, and therefore, contaminate all environmental compartments. The toxicity and the mechanisms by which they affected immune cells are complex and remain unknown. This study investigated the impact of AZO and IPR on the in vitro function of mice peritoneal macrophages including lysosomal enzyme activity and tumor necrosis
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Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-23 Chen‐Lin Yu; Yung‐Luen Yu; Shun‐Fa Yang; Chung‐En Hsu; Chia‐Liang Lin; Yi‐Hsien Hsieh; Hui‐Ling Chiou
Praeruptorin A (PA) is one of the active ingredients found in the dried root of Peucedanum praeruptorum Dunn, has been reported to possess anticancer effects against various types of cancer. However, the effect of PA on human hepatocellular carcinoma (HCC) remains uncleared. In this study, our results indicated that PA did not induce cytotoxicity or alter cell cycle distribution in human HCC cells
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Melatonin attenuates branch chain fatty acid induced apoptosis mediated neurodegeneration Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-21 Shaista Chaudhary; Upasana Sahu; Suhel Parvez
Valproic acid (VPA)—a short branched chain fatty acid (BCFA), is widely recognized as an anticonvulsant and a mood‐stabilizing drug, but various adverse effects of VPA have also been investigated. However, the impact of BCFAs aggregation on brain cells, in the pathogenesis of neurodegeneration remains elusive. The objective of this study is to understand the cellular mechanisms underlying VPA‐induced
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Cover Image Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-13 Yu‐Hsien Lin; Yu‐Jung Lin; Ting‐Hsuan Chang; Yun‐Hsuan Chang; Yun‐Ping Lim; Jing‐Gung Chung; Wen‐Tsong Hsieh
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Protective effects of Saraca indica L. leaves extract (family Fabaceae) against gamma irradiation induced injury in the kidney of female albino rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-09 Marwa Abd El Hameed Mohamed; Hala Sh. Mohammed; Shaimaa Ali Mostafa; Magda Tohamy Ibrahim
This work was designed to estimate the protective effect of Saraca indica L. leaves ethanolic exract against γ‐irradiation induced renal damage in rats. Phytochemical examinations of S. indica L. leaves extract resulted in the separation of three flavanone glycosides: Astilibin (1), Neoastilbin (2), and Eriodictyol‐7‐O‐α‐l‐rhamnopyranoside (3); two flavonols: Quercetin (4) and Quercetin‐3‐O‐α‐l‐ar
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Dichloroacetate attenuates the stemness of colorectal cancer cells via trigerring ferroptosis through sequestering iron in lysosomes Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-09 Jie Sun; Xiuqin Cheng; Shubo Pan; Liangjing Wang; Wenhuan Dou; Jie Liu; Xiaohua Shi
Colorectal cancer stem cell (CSC) has been regarded to be the root of colorectal cancer progression. However, there is still no effective therapeutic method targeting colorectal CSC in clinical application. Here, we investigated the effects of dichloroacetate (DCA) on colorectal cancer cell stemness. We showed that DCA could reduce colorectal cancer cell stemness in a dose‐dependent manner, which is
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Borneol protects against cerulein‐induced oxidative stress and inflammation in acute pancreatitis mice model Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-09 Sapana Bansod; Shrilekha Chilvery; Mohd Aslam Saifi; Tridip Jyoti Das; Hui Tag; Chandraiah Godugu
Borneol is a commonly used flavouring substance in traditional Chinese medicine, which possesses several pharmacological activities including analgesic, antiinflammatory, and antioxidant properties. The aim of this study was to investigate the effects of borneol on cerulein‐induced acute pancreatitis (AP) model. Swiss albino mice were pretreated with borneol (100 and 300 mg/kg) daily for 7 days, before
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Chemomodulatory effect of neferine on DMBA‐induced squamous cell carcinogenesis: Biochemical and molecular approach Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-06 Jingxuan Wang; Yan Hu; Jieying Yuan; Yan Zhang; Yifan Wang; Yingshun Yang; Tahani Awad Alahmadi; Sulaiman Ali Alharbi; Zhizheng Zhuang; Fan Wu
Neferine (NEF) is nontoxic, bisbenzylisoquinoline alkaloid is derived from the seed embryo of lotus, a familiar medicinal plant. Although several mechanisms have been planned, an evident antitumor action pathway of NEF on the oral tumor is still not known. In the current study, we aimed at investigating the protecting effect of NEF against experimental oral carcinoma and clarify its possible mechanism
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Synthesis of sophocarpine triflorohydrazone and its proliferation inhibition and apoptosis induction activity in myeloma cells through Notch3‐p53 signaling activation Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-06 Yong Wang; Wen Li; Fangmei Huang; Xiaojian Wu; Wenbin Chen; Ming Dong; Jie Zhou
Multiple myeloma is indicated by the presence of excessive monoclonal plasma cells in bone marrow, which result in the formation of osteolytic lesions. The present study investigated SCA as anti‐proliferative agent for myeloma cells and explored the mechanism associated. Effect of SCA on viabilities of KRASA12 and AMO‐1 cells was evaluated by MTT assay and apoptotic ratio using flow cytometry. Protein
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Syringin alleviates ovalbumin‐induced lung inflammation in BALB/c mice asthma model via NF‐κB signaling pathway Environ. Toxicol. (IF 3.118) Pub Date : 2020-11-04 Rui Dai; Manman Niu; Ningling Wang; Yan Wang
Asthma is an allergic chronic inflammatory disease of the pulmonary airways, characterized by the infiltration of white blood cells and release of inflammatory cytokines of complex pathways linked to its pathogenesis. Syringin extracted from various medicinal plants has been used extensively for the treatment of inflammatory diseases. Hence, this study was conducted to further explore the protective
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Prostate cancer‐secreted CCN3 uses the GSK3β and β‐catenin pathways to enhance osteogenic factor levels in osteoblasts Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-27 Po‐Chun Chen; Shan‐Chi Liu; Tien‐Huang Lin; Liang‐Wei Lin; Hsi‐Chin Wu; Huai‐Ching Tai; Shih‐Wei Wang; Chih‐Hsin Tang
Prostate cancer osteoblastic bone metastases are incurable and associated with chronic bone pain and a high mortality rate. Osteoclast‐targeting drugs intended to prevent skeletal‐related events associated with prostate cancer bone metastases do not prolong overall survival. Improved understanding of the bone‐derived factors that contribute to prostate cancer osteoblastic bone metastases is required
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Protection of melatonin against long‐term radon exposure‐caused lung injury Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-27 Qianqian Wu; Lijun Fang; Youjing Yang; Aiqing Wang; Xiaoyu Chen; Jiaojiao Sun; Jianmei Wan; Chengjiao Hong; Jian Tong; Shasha Tao; Hailin Tian
Radon is one of the major pathogenic factors worldwide. Recently, epidemiological studies have suggested that radon exposure plays an important role in lung injury, which could further cause cancer. However, the toxic effects and underlying mechanism on lung injury are still not clear. Here, we identified the detailed toxic effects of long‐term radon exposure. Specifically, the manifestations were
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Amphora algae with low‐level ionizing radiation exposure ameliorate D‐galactosamine‐induced inflammatory impairment in rat kidney Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-27 Sawsan M. El‐sonbaty; Fatma S. M. Moawed; Mustafa M. M. Elbakry
d‐Galactosamine (d‐GalN) is a well‐known toxin that causes many metabolic and morphological abnormalities resulting in advanced renal failure and liver damage. Occupational exposure to low‐level ionizing radiation (<1 Gy) was shown to enhance cell protection via attenuating an established inflammatory process. The present study was therefore aimed to investigate the protective impact of Amphora coffaeiformis
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Shunaoxin pills improve the antihypertensive effect of nifedipine and alleviate its renal lipotoxicity in spontaneous hypertension rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-24 Xuanshuo Liu; Shuli Man; Chen Luo; Yu Liu; Yan Liu; Changxiao Liu; Wenyuan Gao
Shunaoxin pills (SNX) have been used to treat cerebrovascular diseases in China since 2005. Hypertension is a major risk factor for cerebrovascular disease. This study aimed to explore the synergistic antihypertensive effect of SNX and nifedipine and whether SNX could alleviate nifedipine‐induced renal lipotoxicity. During administration, systolic blood pressure was measured weekly. After 5 weeks administration
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Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/HO‐1 and SIRT‐1/FOXO‐1 expressions Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-24 Jitendra Kumar; Rakesh Verma; Chandana Haldar
BPS has detrimental effects on human reproductive health and emerged as an environmental contaminant for global health concern. This study deals with the adverse impact of BPS exposure on testicular oxidative stress, inflammation and apoptosis in adult male golden hamster, Mesocricetus auratus and its amelioration by melatonin. BPS (75 mg/kg BW/day) exposure caused testicular impairment as evident
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Molecular mechanisms associated with oxidative damage in the mouse testis induced by LaCl3 Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-24 Jianhui Ji; Fashui Hong; Yingjun Zhou; Tingwu Liu; Dongxue Fan; Xingxiang Zhang; Yutian Lu; Lingling Jiang; Xiaomei Wang; Chen Wang
China is the world's largest rare earth producer and exporter, previous studies have shown that rare earth elements can cause oxidative damage in animal testis. However, the molecular mechanisms underlying these observations have yet to be elucidated. In this paper, male mice were fed with different doses (10, 20, and 40 mg/kg BW) of LaCl3 for 90 consecutive days, regulatory role of nuclear factor
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Silver nanocolloid affects hindbrain vascular formation during medaka embryogenesis Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-24 Tomomi Matsukura; Chisato Kataoka; Yohei Kawana; Misato Fujita; Shosaku Kashiwada
Angiogenesis is essential for the normal development of an embryo. Silver nanocolloid (SNC) is known to induce vascular malformation in the medaka embryo. We focused on the development of the central arteries (CtAs) in the hindbrain of Japanese medaka. The CtAs and the basilar artery from which they branch are essential for transporting the blood and nutrients necessary to support the hindbrain parenchyma
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SH3PXD2A‐AS1/miR‐330‐5p/UBA2 ceRNA network mediates the progression of colorectal cancer through regulating the activity of the Wnt/β‐catenin signaling pathway Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-19 Shuang Guo; Kong‐xi Zhu; Wei‐hua Yu; Teng Wang; Shuai Li; Yun‐xia Wang; Chen‐chen Zhang; Jian‐qiang Guo
Long non‐coding RNAs have important roles in the occurrence and progression of various cancers. However, the molecular mechanism of lncRNAs in colorectal cancer (CRC) is not well illustrated. Thus, we used bioinformatics methods to find potential lncRNAs associated with CRC progression, and chose SH3PXD2A‐AS1 as a candidate for further analysis. The roles of SH3PXD2A‐AS1 in CRC cells were determined
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Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12‐dimethylbenz[a]anthracene‐induced hamster oral cancer via the down‐regulation of PI3K/AKT/mTOR signaling pathways Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-17 Yumei Pu; Shiqi Hu; Yongfeng Chen; Qian Zhang; Chengwan Xia; Han Deng; Yuxin Wang; Qingang Hu
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Vitamin K protects against 7,12‐dimethylbenz(A)anthracene induced hepatotoxicity in Wistar rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-16 Oluwatosin Adebisi Dosumu; Solomon Oladapo Rotimi; Oluwagbemiga Olanrewaju Adeleye; Adio Jamiu Akamo; Kehinde Temitope Osinuga; Odunayo Anthonia Taiwo; Oluwatosin Oyebola Omotosho; Latifah Oyefoluke Sani
Humans are daily exposed to 7,12‐dimethylbenz(a)anthracene (DMBA), a well known polycyclic aromatic hydrocarbons (PAH). This study investigated the role of dietary intake of Vitamin K (VK), a polyphenolic compound, with potential antioxidative properties, against DMBA‐induced hepatotoxicity. Sixty experimental animals (120‐150 g) were divided into six groups (A‐F): Control, DMBA (80 mg/kg bw) only
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Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-15 Ling‐Ling Zhao; Emmanuel Ayobami Makinde; Opeyemi Joshua Olatunji
Diabetic mellitus is a chronic metabolic disorder that is associated with several complications including testicular dysfunction. This research investigated the protective action of the ethyl acetate extract from Shorea roxburghii (SRE) on diabetes induced testicular damage in rats. Diabetic rats were orally administered with SRE at doses of 100 and 400 mg/kg for 4 weeks. SRE improved the body weight
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Benzo[a]pyrene exposure and overcrowding stress impacts anxiety‐like behavior and impairs learning and memory in adult zebrafish, Danio rerio Environ. Toxicol. (IF 3.118) Pub Date : 2020-10-14 Sai Aparna; Manorama Patri
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