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Propolis alleviates 4‐aminobiphenyl‐induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-04-13 Eva Ari Wahyuni, Chien Yi Chen, Huery Nuo Wu, Chih‐Ching Chien, Ssu‐Ching Chen
4‐Aminobiphenyl (4‐ABP) may cause DNA damage in human liver cells (HepG2 and L‐02). Propolis exhibits antioxidant properties through reactive oxygen species (ROS) scavenging. We determined the effects of propolis in alleviating 4‐ABP ‐induced DNA damage using the comet assay. Results revealed that propolis could significantly alleviated oxidative damaged DNA by 4‐ABP. Furthermore, we proved that inhibition
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Trans‐ovo permethrin exposure affects growth, brain morphology and cardiac development in quail Environ. Toxicol. (IF 3.118) Pub Date : 2021-04-12 Grace H. Curtis, Sara Nogueiro, Sydney Schneider, Marissa Bernhofer, Mara McDermott, Erin Nixon, Kylie Noelle Perez, Robyn E. Reeve, Marietta R. Easterling, Erica J. Crespi
Permethrin is a commonly used, highly effective pesticide in poultry agriculture, and has recently been trialed in conservation efforts to protect Galápagos finch hatchlings from an invasive ectoparasite. Although permethrin is considered safe for adults, pesticides can have health consequences when animals are exposed during early life stages. The few studies that have examined permethrin's effects
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MicroRNA‐17‐5p restrains the dysfunction of Ang‐II induced podocytes by suppressing secreted modular calcium‐binding protein 2 via NF‐κB and TGFβ signaling Environ. Toxicol. (IF 3.118) Pub Date : 2021-04-09 Mingzhu Xu, Mengqiu Yi, Na Li
Glomerulonephritis, also known as nephritis syndrome (nephritis for short), is a common kidney disease. Previous research has proved that microRNAs (miRNAs) frequently regulate various diseases including nephritis. Nonetheless, the biological function and molecular mechanism of miR‐17‐5p are unclear in nephritis. In the current study, RT‐qPCR analysis showed that miR‐17‐5p was downregulated in Ang
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Mechanisms underlying protective effects of vitamin E against mycotoxin deoxynivalenol‐induced oxidative stress and its related cytotoxicity in primary human brain endothelial cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-04-05 Pochuen Shieh, Shu‐Shong Hsu, Wei‐Zhe Liang
Fusarium mycotoxins are one of the largest families of mycotoxins. Among these mycotoxins, deoxynivalenol is the most widespread pollutant of grains. However, the mechanism underlying the effect of deoxynivalenol on cytotoxicity in human brain endothelial cells was still unclear. This study examined whether deoxynivalenol induced oxidative stress‐associated cytotoxicity in primary human brain endothelial
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ROCK inhibitor attenuates carbon blacks‐induced pulmonary fibrosis in mice via Rho/ROCK/NF‐kappa B pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-31 Junyan Yan, Yaxin Tang, Xin Zhong, Huarong Huang, Haonan Wei, Yulei Jin, Yanjiang He, Jinqiao Cao, Lifang Jin, Baowei Hu
Exposure to carbon blacks (CBs) has been associated with the progression of pulmonary fibrosis, whereas the mechanism is still not clear. We therefore aimed to investigate the effect of RhoA/ROCK pathway on pulmonary fibrosis caused by CBs exposure. Western blot analysis indicated that CBs could promote the activation of RhoA/ROCK pathway and phosphorylation of p65 and IκBα in mice lung. However, ROCK
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Long noncoding RNA MCF2L‐AS1 promotes the cancer stem cell‐like traits in non‐small cell lung cancer cells through regulating miR‐873‐5p level Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-30 Shouguo Li, Liancheng Lin
The roles of long noncoding RNA (lncRNA) MCF2L‐AS1 have been identified in colorectal cancer, however, its roles in lung cancer progression have never been revealed. Here, we found that lncRNA MCF2L‐AS1 was highly expressed in lung cancer tissues and cells, especially in non‐small cell lung cancer (NSCLC). Functional experiments showed that MCF2L‐AS1 knockdown suppressed the cancer stem cell (CSC)‐like
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Chronic lung inflammation and pulmonary fibrosis after multiple intranasal instillation of PM2.5 in mice Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-29 Mengmeng Xu, Xiaohui Wang, Lu Xu, Hai Zhang, Chenfei Li, Qi Liu, Yuqing Chen, Kian Fan Chung, Ian M. Adcock, Feng Li
Fine particulate matter (PM2.5) is an important component of air pollution and can induce lung inflammation and oxidative stress. We hypothesized that PM2.5 could play a role in the induction of pulmonary fibrosis. We examined whether multiple intranasal instillation of PM2.5 can induce pulmonary fibrosis in the mouse, and also investigated the underlying pro‐fibrotic signaling pathways. C57/BL6 mice
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Cytotoxicity of mesoporous silica modified by amino and carboxyl groups on vascular endothelial cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-25 Ji Zhao, De‐yun Bu, Na Zhang, Da‐nian Tian, Li‐ya Ma, Hui‐fang Yang
Mesoporous silica is widely used because of its unique and excellent properties, especially it can be used as a drug carrier and gene carrier in the biomedical field. After the mesoporous silica is put into clinical use, it is more likely to be exposed in human body. Therefore, the effect of mesoporous silica on human body cannot be ignored. The injury of vascular endothelial cells is a prerequisite
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Activation of Nrf2/HO‐1 signaling pathway attenuates ROS‐mediated autophagy induced by silica nanoparticles in H9c2 cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-25 Guanqun Cui, Ziyuan Li, Feifei Cao, Peng Li, Minghua Jin, Shanshan Hou, Xu Yang, Yingwen Mu, Cheng Peng, Hua Shao, Zhongjun Du
Silica nanoparticles (SiNPs) as one of the most productive nano‐powder, has been extensively applied in various fields. There has been increasing concern about the adverse effects of SiNPs on the health of ecological organisms and human. The potential cardiovascular toxicity of SiNPs and involved mechanisms remain elusive. Hence, in this study, we investigated the cardiovascular toxicity of SiNPs (60 nm)
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In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-24 Mariana Pires Teixeira, Eliza Freitas Passos, Natalia Ferreira Haddad, Marcelle Novaes Andrade, Vivian Mary Rumjanek, Leandro Miranda‐Alves, Denise Pires de Carvalho, Luciana Souza de Paiva
Ouabain is a steroid described as a compound extracted from plants that is capable of binding to Na+, K+‐ATPase, inhibiting ion transport and triggering cell signaling pathways. Due to its positive ionotropic effect, ouabain was used for more than 200 years for the treatment of cardiac dysfunctions. Numerous antitumor effects of ouabain have been described so far; however, its role on thyroid cancer
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Panax ginseng modulates oxidative stress, DNA damage, apoptosis, and inflammations induced by silicon dioxide nanoparticles in rats Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-21 Fatma M. El‐Demerdash, Mohammed A. El‐Magd, Raghda A. El‐Sayed
Silicon dioxide nanoparticles (SiO2NPs) are extensively used in cosmetics, food, and drug delivery. The main mechanism of SiO2NPs toxicities depends on oxidative stress. Ginseng (Panax ginseng Meyer) is used in various medicinal applications because of its antioxidant efficiency. Therefore, the present study was carried out to investigate the possible combated role of ginseng against SiO2NPs toxicity
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High‐fat diet exacerbates lead‐induced blood–brain barrier disruption by disrupting tight junction integrity Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-21 Chao Li, Liang Shi, Yuanbo Wang, Cheng Peng, Lei Wu, Yanshu Zhang, Zhongjun Du
Environmental exposure to lead (Pb) can damage to the central nervous system (CNS) in humans. High‐fat diet (HFD) also has been suggested to impair neurocognitive function. Blood–brain barrier (BBB) is a rigorous permeability barrier for maintaining homeostasis of CNS. The damage of BBB caused by tight junctions (TJs) disruption is central to the etiology of various CNS disorders. This study aimed
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Running head MBP‐activated autoimmunity plays a role in arsenic‐induced peripheral neuropathy and the potential protective effect of mecobalamin Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-19 Qican He, Bingzhi Chen, Shaoyi Chen, Muyang Zhang, Lidan Duan, Xiangling Feng, Jihua Chen, Lezhou Zhou, Lv Chen, Yanying Duan
Intake excessive arsenic (As) is related to the occurrence of peripheral neuropathy. However, both the underlying mechanism and the preventive approach remain largely unknown. In the present study, As treatment significantly decreased the mechanical withdrawal threshold and increased the titer of anti‐myelin basic protein antibody in rats, accompanied with damaged BNB. The levels of inflammatory cytokines
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Effect of resveratrol on the inflammatory status and oxidative stress in thymus gland and spleen of sulfoxaflor‐treated rats Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-18 Samah M. Fathy, Ibrahim Y. Abdelkader
Resveratrol (Res), a polyphenolic compound that exerts mitigating consequences against various insults due to its antioxidant, anti‐inflammatory, and immunomodulatory properties. Sulfoxaflor (SFX), a neonicotinoid insecticide, has been used worldwide and leading to deleterious effects on the environment and public health. The current study aimed to investigate the protective effect of Res on the inflammatory
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CircKDM4C upregulates P53 by sponging hsa‐let‐7b‐5p to induce ferroptosis in acute myeloid leukemia Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-18 Li‐hua Dong, Jing‐jing Huang, Peng Zu, Jing Liu, Xue Gao, Jian‐wei Du, Yu‐fu Li
To investigate the role of circKDM4C in acute myeloid leukemia (AML), the expression of circKDM4C, hsa‐let‐7b‐5p, and P53 was measured by qRT‐RCR. AML cell lines(K‐562 and HL‐60) were transfected correspondingly and investigated for cell proliferation, migration, and invasion abilities by CCK‐8, colony formation, transwell, and wound healing assays, respectively. The levels of P53, ACSL4, PTGS2, GPX4
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AXL is crucial for E1A‐enhanced therapeutic efficiency of EGFR tyrosine kinase inhibitors through NFI in breast cancer Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-18 Chih‐Ming Su, Tung‐Wei Hsu, Shian‐Ying Sung, Ming‐Te Huang, Kuan‐Chou Chen, Chih‐Yang Huang, Chien Yi Chiang, Yen‐Hao Su, Hsin‐An Chen, Po‐Hsiang Liao
AXL which is a chemosensitizer protein for breast cancer cells in response to epidermal growth factor receptor‐tyrosine kinase inhibitor and suppresses tumor growth. The clinical information show nuclear factor I (NFI)‐C and NFI‐X expression correlate with AXL expression in breast cancer patients. Following, we establish serial deletions of AXL promoter to identify regions required for Adenovirus‐5
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Shenlian extract protects against ultrafine particulate matter‐aggravated myocardial ischemic injury by inhibiting inflammation response via the activation of NLRP3 inflammasomes Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-17 Shuiqing Qu, Kai Li, Ting Yang, Yuanmin Yang, Zhongyuzn Zheng, Hui Liu, Xi Wang, Yu Zhang, Shuoqiu Deng, Xiaoxin Zhu, Lina Chen, Yujie Li
Air pollution is a growing public health burden associated with several negative health effects, especially cardiovascular disease. Shenlian extract (SL), a traditional Chinese medicine, has the effects of clearing heat‐toxin and promoting blood circulation for removing blood stasis, and it has long been used to treat cardiovascular diseases and atherosclerosis. This study explored the underlying action
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Maternal exposure to tributyltin during early gestation increases adverse pregnancy outcomes by impairing placental development Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-15 Hui Liu, Wenyu Jiang, Yafen Ye, Bei Yang, Xin Shen, Siying Lu, Jun Zhu, Mengling Liu, Chuanzhen Yang, Haibin Kuang
Tributyltin (TBT) is a persistent organotin pollutant widely used as agricultural and wood biocides, exhibiting well‐documented toxicity to reproductive functions in aquatic organisms. However, the effect of TBT on early pregnancy and placental development has been rarely studied in mice. Pregnant mice were fed with 0, 0.2, and 2 mg/kg/day TBT from gravid day 1 to day 8 or 13. TBT exposure led to an
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Sub‐chronic exposure to ammonia inhibits the growth of juvenile Wuchang bream (Megalobrama amblycephala) mainly by downregulation of growth hormone/insulin‐like growth factor axis Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-15 Honghui Guo, Wang Lin, Liping Yang, Yuming Qiu, Yu Kuang, Hui Yang, Ce Zhang, Li Li, Dapeng Li, Rong Tang, Xi Zhang
In this study, healthy Wuchang bream (Megalobrama amblycephala) juveniles were exposed to 0, 5, 10, 20 and 30 mg/L total ammonia nitrogen for 30 days to elucidate toxic effects and mechanisms of ammonia on growth performance involved with the regulation of growth hormone/insulin‐like growth factor (GH/IGF) and hypothalamic–pituitary‐thyroid (HPT) axes. Our results showed that the increasing total ammonia
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Sinapic acid mitigates methotrexate‐induced hepatic injuries in rats through modulation of Nrf‐2/HO‐1 signaling Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-15 Ajaz Ahmad, Khalid M. Alkharfy, Yousef A. Bin Jardan, Mudassar Shahid, Mushtaq Ahmad Ansari, Saeed Alqahtani, Basit L. Jan, Fahad I. Al‐Jenoobi, Mohammad Raish
The present research has been investigated to study the protective outcomes of sinapic acid (SA) against methotrexate (MTX) encouraged liver damage in rats by modulating the Nrf2/HO‐1 and NF‐κB signaling pathways. The animals were arbitrarily allocated into four groups: group I rats administered a 0.5% carboxymethyl cellulose (CMC) vehicle orally for 15 consecutive days with a single intravenous standard
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Silica dust exposure induces pulmonary fibrosis through autophagy signaling Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-15 Ning Li, Fan Shi, Xiaoyan Wang, Pan Yang, Kun Sun, Lin Zhang, Xiaohui Hao, Xiaoming Li, Jinlong Li, Yulan Jin
Silicosis is a well‐acknowledged occupational lung disease caused by inhalation of a large amount of free silica dust during the production period and eventually a considerable negative impact on the patients' quality of life. Autophagy exerts a critical influence on immune and inflammatory responses during the pathogenesis of pulmonary fibrosis. In this study, we sought to determine whether autophagy
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A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl‐1 downregulation in human breast cancer cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-13 Chang‐Fang Chiu, Shih‐Jiuan Chiu, Li‐Yuan Bai, Chia‐Hsien Feng, Jing‐Lan Hu, Wei‐Yu Lin, Hao‐Yu Huang, Jing‐Ru Weng
Secondary metabolites in marine organisms exhibit various pharmacological activities against diseases, such as cancer. In this study, the anti‐proliferative effect of JBIR‐100, a macrolide isolated from Streptomyces sp., was investigated in breast cancer cells. Cell growth was inhibited in response to JBIR‐100 treatment concentration‐ and time‐dependently in both MCF‐7 and MDA‐MB‐231 breast cancer
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Trimetazidine improved adriamycin‐induced cardiomyopathy by downregulating TNF‐α, BAX, and VEGF immunoexpression via an antioxidant mechanism Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-11 Basma G. Eid, Nagla Abd El‐Aziz El‐Shitany, Thikryat Neamatallah
Few studies have reported a prophylactic effect of the anti‐ischemic trimetazidine (TRI) against cardiac toxicity caused by adriamycin (ADR). However, the mechanism of action of TRI remained incomplete. The cardioprotective mechanism(s) of TRI against ADR‐induced cardiotoxicity was investigated in this study. Cardiotoxicity was induced in three groups of Wistar rats by injecting a single dose of ADR
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Tribulus terrestris fruit extract inhibits autophagic flux to diminish cell proliferation and metastatic characteristics of oral cancer cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-10 Chih‐Wen Shu, Jing‐Ru Weng, Hsueh‐Wei Chang, Pei‐Feng Liu, Jih‐Jung Chen, Chien‐Chi Peng, Jia‐Wen Huang, Wei‐Yu Lin, Ching‐Yu Yen
Elevated autophagy is highly associated with cancer development and progression. Fruit extracts of several plants inhibit activity of autophagy‐related protease ATG4B and autophagy activity in colorectal cancer cells. However, the effects of these plant extracts in oral cancer cells remain unclear. In this study, we found that the extracted Tribulus terrestris fruit (TT‐(fr)) and Xanthium strumarium
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Perfluorotridecanoic acid inhibits fetal Leydig cell differentiation after in utero exposure in rats via increasing oxidative stress and autophagy Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-08 Changchang Li, Cheng Zou, Haoni Yan, Zengqiang Li, Yang Li, Peipei Pan, Feifei Ma, Yige Yu, Yiyan Wang, Zina Wen, Ren‐Shan Ge
Perfluorotridecanoic acid (PFTrDA) is a long‐chain perfluoroalkyl substance, and its effect on the differentiation of fetal Leydig cells remains unclear. The objective of this study is to explore the effect of in utero PFTrDA exposure on the differentiation of fetal Leydig cells and investigate its underlying mechanisms. Pregnant Sprague–Dawley female rats were daily administered by gavage of PFTrDA
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Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-04 Xufeng Fu, Hang Han, Yuanyuan Li, Bo Xu, Wenjie Dai, Yaoxu Zhang, Feng Zhou, Huiming Ma, Xiuying Pei
Di‐(2‐ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it is widely applied in various plastic products. DEHP is an endocrine‐disrupting chemical (EDC) that has been shown to disrupt the function of reproductive system in females. Although many studies have shown that DEHP potentially causes female reproductive toxicity, including depletion of the primordial follicle
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Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53 Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-03 Shaoping Huang, Ying Lu, Suying Li, Tao Zhou, Jing Wang, Jiangyan Xia, Xinxin Zhang, Zuomin Zhou
Fenvalerate (Fen) is an endocrine disruptor, capable of interfering with the activity of estrogen and androgen. Our objective was to explore the molecular mechanisms of Fen on sperm in vivo. Adult male Sprague–Dawley rats were orally exposed to 0, 0.00625, 0.125, 2.5, 30 mg/kg/day Fen for 8 weeks. Sperm morphology, differential proteomics of sperm and testes, bioinformatic analysis, western blotting
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The crosstalk between mitochondrial dysfunction and endoplasmic reticulum stress promoted ATF4‐mediated mitophagy induced by hexavalent chromium Environ. Toxicol. (IF 3.118) Pub Date : 2021-03-02 Mongameli B. Dlamini, Zeyun Gao, Hasenbilige, Liping Jiang, Chengyan Geng, Qiujuan Li, Xiaoxia Shi, Yong Liu, Jun Cao
Chromium (Cr) compounds are markedly toxic and carcinogenic. Previously, we found that Cr (VI) induced autophagy in A549 cells. Here, the effect of mitochondrial dysfunction and endoplasmic reticulum (ER) stress on inducing mitophagy was investigated in both A549 and H1299 cells. Exposure to Cr (VI) for 6 h significantly enhanced reactive oxygen species (ROS) production and reduced mitochondrial membrane
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Parental PM2.5 exposure changes Th17/Treg cells in offspring, is associated with the elevation of blood pressure Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-19 Kun Pan, Shuo Jiang, Xihao Du, Xuejiao Zeng, Jia Zhang, Liying Song, Lei Lei, Ji Zhou, Haidong Kan, Qinghua Sun, Yuquan Xie, Chen Dong, Jinzhuo Zhao
Epidemiological evidences have indicated that fine particulate matter (PM2.5) exposure is associated with the occurrence and development of hypertension. The present study aims to explore the effects of parental PM2.5 exposure on blood pressure in offspring and elucidate the potential mechanism. The parental male and female C57BL/6 mice were exposed to concentrated PM2.5 or filtered air (FA) using
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The effect of reproductive toxicity induced by ZnO NPs in mice during early pregnancy through mitochondrial apoptotic pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-18 Ling Chen, Haifang Wu, Wuding Hong, Zoraida P. Aguilar, Fen Fu, Hengyi Xu
The potential toxicity of Zinc oxide nanoparticles (ZnO NPs) to human beings has become a widespread concern. This study explored the reproductive toxicity and the mechanism of toxicity of ZnO NPs in early pregnant mice. The results showed that abnormal weight changes, induced inflammation, reduced level of serum sex hormones, damaged uterus, increased abortion, and abnormal development of fetus. In
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DNA damage induced by cylindrospermopsin on different tissues of the biomonitor fish Poecilia reticulata Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-12 Jéssica C. S. Rabelo, Alex L. Hanusch, Lázaro Wender O. de Jesus, Lorena A. Mesquita, Fernanda C. Franco, Raquel A. Silva, Simone M. T. Sabóia‐Morais
The cyanotoxin cylindrospermopsin (CYN) is the second biggest cause of poisoning worldwide, both in humans and animals. Although CYN primarily affects the aquatic environments and can be absorbed in fishes by multiple routes, data reporting its toxicity and mechanism of action are still scarce in this group. Using P. reticulata as model species, it was evaluated whether CYN promotes mutagenic and genotoxic
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Cadmium cytotoxicity and possible mechanisms in human trophoblast HTR‐8/SVneo cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-09 Ying Liao, Hong Zheng, Langbo Wu, Lei He, Yu Wang, Yangsong Ou, Hongjun Yang, Shiqin Peng, Fengwang Chen, Xiaoyan Wang, Jiayuan Zhao
The accumulation of cadmium (Cd) in the human body through food chain can lead to adverse pregnancy outcomes. In this study, Cd cytotoxicity and its mechanisms in HTR‐8/SVneo cells were investigated. Cd disrupted the cellular submicrostructure and inhibited the cell viability in a time‐ and dose‐dependent manner. The levels of reactive oxygen species, malondialdehyde content, and the activities of
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LncRNA MEG3 mediates nickel oxide nanoparticles‐induced pulmonary fibrosis via suppressing TGF‐β1 expression and epithelial‐mesenchymal transition process Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-06 Haibing Zhan, Xuhong Chang, Xiaoxia Wang, Mengmeng Yang, Qing Gao, Han Liu, Chengyun Li, Sheng Li, Yingbiao Sun
Nickel oxide nanoparticles (NiO NPs) causes pulmonary fibrosis via activating transforming growth factor‐β1 (TGF‐β1) in rats, but its upstream regulatory mechanisms are unknown. This study aimed to explore the role of long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) in NiO NPs‐induced collagen deposition. Male Wistar rats were intratracheally instilled with NiO NPs (0.015, 0.06, and 0
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SMAR1 attenuates the stemness of osteosarcoma cells via through suppressing ABCG2 transcriptional activity Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-05 Hongyu Xu, Ting Liu, Wenjie Li, Qi Yao
The promoting roles of the transcriptional regulator SMAR1 have been revealed in several tumors, such as colorectal and breast cancer, however, its roles in osteosarcoma (OS) progression are still confusing. Here, we find that SMAR1 expression is positively correlated with the overall survival of OS patients and negatively correlated with the expression of stemness markers by analyzing the online datasets
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Curcumin suppresses the stemness of non‐small cell lung cancer cells via promoting the nuclear‐cytoplasm translocation of TAZ Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-04 Yuzhen Zheng, Xingping Yang, Jian Tan, Renjiang Tian, Piao Shen, Weijie Cai, Hongying Liao
Curcumin has been shown to suppress the progression of lung cancer, however, the underlying mechanisms are largely unknown. Here, we aimed to investigate the effects of curcumin on the stemness of non‐small cell lung cancer (NSCLC) cells. We found that curcumin reduced the sphere formation ability at the concentrations without affecting the cell viability of NSCLC cells and normal pulmonary epithelial
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SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-01 Sizhen Li, Qingsong Yang, Zixiu Zhou, Min Fu, Xiaodong Yang, Kuanxiao Hao, Yating Liu
Glaucoma is the main reason for irreversible blindness, and pathological increased intraocular pressure is the leading risk factor for glaucoma. It is reported that trabecular meshwork cell injury is closely associated with the elevated intraocular pressure. The current study aimed to investigate the role of small nucleolar RNA host gene 3 (SNHG3) in human trabecular meshwork (HTM) cells under oxidative
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Verbascoside inhibits the epithelial‐mesenchymal transition of prostate cancer cells through high‐mobility group box 1/receptor for advanced glycation end‐products/TGF‐β pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-01 Chun‐Hsien Wu, Chung‐Hsien Chen, Pei‐Fang Hsieh, Yen‐Hsi Lee, Wade Wei‐Ting Kuo, Richard Chen‐Yu Wu, Chih‐Hsin Hung, Yu‐Lin Yang, Victor C. Lin
Prostate cancer has significant mortality and metastasis rate in the male. Unfortunately, effective treatment for patients with advanced prostate cancer is still lacking. Verbascoside, a phenylethanoid glycoside, displays various pharmacological properties, such as the anti‐cancer activities. The present study aimed to evaluate the effects of purified verbascoside on human prostate cancer and the associated
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Potential chemotherapeutic effect of betalain against human non‐small cell lung cancer through PI3K/Akt/mTOR signaling pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-02-01 Zongxiu Yin, Yanna Yang, Tianfang Guo, Vishnu Priya Veeraraghavan, Xin Wang
This work focuses on evaluating the therapeutic ability of betalain and its causal mechanisms in NSCLC both in vivo and in vitro. The experimental results demonstrated that betalain was able to reduce the viability of A549 cells dose dependently with undetectable toxicity toward normal human cells. Betalain also augmented the apoptotic cells of A549 and cell cycle arrest which was evidenced via increased
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Intergenerational thyroid hormone homeostasis imbalance in cerebellum of rats perinatally exposed to glyphosate‐based herbicide Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-29 Luã Tainã Costa Reis, Janaina Sena de Souza, Roberto Hirochi Herai, Eduardo Brunetti Cunha, Janaina Ribeiro Pereira Soares, Ramon Santos El‐Bachá, Victor Diogenes Amaral da Silva, Marco Aurelio Romano, Renata Marino Romano, Maria Izabel Chiamolera, Gisele Giannocco, Silvia Lima Costa, Magnus Régios Dias da Silva, Suzana Telles da Cunha Lima
Agrochemicals became a public health concern due to increased human exposure and possible endocrine disruption effects in several organs, including the brain. Thyroid hormones controls neurodevelopment, which turn them sensitive to endocrine disruptors (EDs). In this work, we evaluated the effect of glyphosate‐based herbicides (GBH) as an intergenerational endocrine disrupter on thyroid homeostasis
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Melatonin increases the anticancer potential of doxorubicin in Caco‐2 colorectal cancer cells Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-28 Mahdieh Farhoudi Sefidan Jadid, Elnaz Aghaei, Elham Taheri, Nasrin Seyyedsani, Reza Chavoshi, Samane Abbasi, Afshin Khorrami, Pouya Goleij, Saba Hajazimian, Sina Taefehshokr, Alireza Isazadeh, Dariush Shanehbandi
Colorectal cancer (CC) is an important human malignancy with high cancer related death worldwide. The chemotherapy using doxorubicin hydrochloride is one of the most common cancer therapeutic methods. However, drug resistance lowers the treatment efficacy in CC patients. The combination therapies seem to be more promising by taking the advantage of synergistic effects. The present study aimed to evaluate
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Enhanced anticancer potency of hydroxytyrosol and curcumin by PLGA‐PAA nano‐encapsulation on PANC‐1 pancreatic cancer cell line Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-26 Mahdieh Farhoudi Sefidan Jadid, Behrouz Shademan, Reza Chavoshi, Nasrin Seyyedsani, Elnaz Aghaei, Elham Taheri, Pouya Goleij, Saba Hajazimian, Vahidreza Karamad, Javad Behroozi, Mehrdad Nasrollahzadeh Sabet, Alireza Isazadeh, Behzad Baradaran
Many chemotherapeutic regimens have been investigated for advanced unresectable and metastatic pancreatic cancer (PC), but with only minimal improvement in survival and prognosis. Here, we investigated anti‐cancer function of free and nano‐encapsulated hydroxytyrosol (Hyd) and curcumin (Cur), and its combinations (Hyd‐Cur) on PANC‐1 cell line. The poly lactide‐co‐glycolide‐co‐polyacrylic acid (PLGA‐co‐PAA)
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Hsa_circ_0001073 targets miR‐626/LIFR axis to inhibit lung cancer progression Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-21 Qun Liu, Gang Cao, Yufeng Wan, Chuanqin Xu, Yuanqiang He, Gang Li
Circular RNAs (circRNAs) are associated with lung cancer progression. However, it is unclear whether and how circRNA hsa_circ_0001073 (circ_0001073) are involved in lung cancer progression. circ_0001073, microRNA (miR)‐626, and leukemia inhibitory factor receptor (LIFR) abundances were determined via quantitative reverse transcription polymerase chain reaction or western blot. Cell viability, invasion
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Anti‐apoptotic and pro‐survival effects of longan flower extracts on rat hearts with fructose‐induced metabolic syndrome Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-21 Shiu‐Min Cheng, V. Bharath Kumar, Liang‐Yi Wu, Hsiao‐Chuan Chang, Chia‐Hua Kuo, Li‐Shan Wei, Yueh‐Min Lin, V. Vijaya Padma, Shin‐Da Lee, Chih‐Yang Huang
The aim of this study was to investigate the effects of longan flower (LF) water extract on cardiac apoptotic and survival pathways in rat models of fructose‐induced metabolic syndrome. The study findings revealed that the levels of glucose, insulin, triglyceride, and cholesterol and TUNEL‐positive apoptotic cells were significantly increased in the HF group compared with the control group; whereas
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Cardioprotective potential of amygdalin against angiotensin II induced cardiac hypertrophy, oxidative stress and inflammatory responses through modulation of Nrf2 and NF‐κB activation Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-15 Yen‐Lun Kung, Cheng‐You Lu, Khan Fareen Badrealam, Wei‐Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray‐Jade Chen, Shang‐Yeh Lu, Viswanadha Vijaya Padma, Chih‐Yang Huang
Heart failure (HF) and cardiac hypertrophy is an unfavorable outcome of pathological cardiac remodeling and represents the most important contributing factor for HF and cardiac hypertrophy. Amygdalin (AMG) is a cyanogenic glycoside derived from bitter almonds. Accumulating evidences have highlighted their pharmacological potentials against various diseases. However, there is no report delineating the
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Integrated analysis of multi‐omics data on epigenetic changes caused by combined exposure to environmental hazards Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-13 So Yeon Yu, Eun Jung Koh, Seung Hwan Kim, So Yul Lee, Ji Su Lee, Sang Wook Son, Seung Yong Hwang
Humans are easily exposed to environmentally hazardous factors in industrial sites or daily life. In addition, exposure to various substances and not just one harmful substance is common. However, research on the effects of combined exposure on humans is limited. Therefore, this study examined the effects of combined exposure to volatile organic compounds (VOCs) on the human body. We separated 193
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Puerarin prevents cadmium‐induced disorder of testicular lactic acid metabolism in rats by activating 5′ AMP‐activated protein kinase (AMPK)/sirtuin 1 (SIRT1) signaling pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-06 Wenxuan Dong, Kanglei Zhang, Gang Liu, Yun Tan, Hui Zou, Yan Yuan, Jianhong Gu, Ruilong Song, Jiaqiao Zhu, Zongping Liu
Cadmium (Cd) interferes with the function of the male reproductive system; however, the molecular mechanism is poorly understood. This study aimed to evaluate the effect of puerarin (PU) on Cd‐induced testicular lactic acid metabolism disorder. Weaning male Sprague–Dawley rats were pre‐fed for 7 days, weighed, and randomly divided into four groups: Control group, CdAc2 group, CdAc2 + PU group, PU group
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The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3/Caspase‐1 signaling pathway and oxidative stress in Wistar rats Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-06 Jialiu Wei, Xifeng Wang, Qian Liu, Na Zhou, Shuxiang Zhu, Zekang Li, Xiaoli Li, Jinpeng Yao, Lianshuang Zhang
The extensive existing of microplastics (MPs) in the ecosystem have increased considerable attention concerning their potential adverse effects, the toxicities and the underlying mechanism of MPs are still scarce. To explore the effect of MPs on cardiac tissue in Wistar rats and unravel the mechanism of pyroptosis and oxidative stress in the process of cardiomyocytes injury, 32 male Wister rats were
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Dichloroacetate attenuates the stemness of hepatocellular carcinoma cells via promoting nucleus‐cytoplasm translocation of YAP Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-06 Duanyu Su, Zhian Lin
The antitumor effects of dichloroacetate (DCA) have been widely explored, however, its roles in hepatocellular carcinoma (HCC) progression are still unclear. In the current work, we found that DCA had little effects on HCC cell viability, but could attenuate the stemness of HCC cells, which is evident by decreasing the tumor sphere‐formation ability, ALDH activity and the expression of stemness critical
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Cyclopiazonic acid induced p53‐dependent apoptosis in the testis of mice: Another male related risk factor of infertility Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-05 Farzaneh Bonyadi, Shapor Hasanzadeh, Hassan Malekinejad
Cyclopiazonic acid (CPA) is an indole tetrameric acid mycotoxin. This study carried out to investigate the potential effects of CPA on male reproductive system. In the current study, 40 adult male mice were divided into five groups (n = 8). The control group did not expose to CPA, while animals in vehicle‐received group; received the CPA‐solvent (0.05% dimethyl sulfoxide) and the animals of third,
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Linseed ameliorates renal apoptosis in rat fetuses induced by single or combined exposure to diesel nanoparticles or fenitrothion by inhibiting transcriptional activation of p21/p53 and caspase‐3/9 through pro‐oxidant stimulus Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-04 Khairy A. Ibrahim, Hala A. Abdelgaid, Mohamed Ali El‐Desouky, Abdelgawad Ali Fahmi, Mohamed M. Abdel‐Daim
Gestational exposure to environmental pollutants can induce oxidative injury and apoptosis since the fetal organs are sensitively vulnerable to these chemicals. In this work, we have investigated the renal anti‐apoptotic efficiency of linseed (LS) against the oxidative stress‐mediated upregulation of the fetal apoptosis‐related genes following the prenatal intoxication with diesel nanoparticles (DNPs)
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The antimammary tumor effects of ethanolic extract of propolis from Adamawa region (Cameroon) are by apoptosis via reactive oxygen species‐mediated mitochondrial pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-04 Stéphane Zingue, Julia Cisilotto, Robinson Charly Mbe Fogang, Edwige Nana Tchoupang, Derek Tantoh Ndinteh, Nestor‐Fernand Tchuenguem Fohouo, Dieudonné Njamen, Tânia Beatriz Creczynski‐Pasa
Identification of novel natural treatment to combat cancer is a current need. This study was aimed at assessing the anticancer effects of ethanol‐extracted Cameroonian propolis (EEP). The antitumor effect of EPP was evaluated in vitro by measuring; cell viability, cell cycle, cell death mechanism, cell migration/invasion, reactive oxygen species (ROS), mitochondrial potential (ΔΨm), caspase activity
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Hydromethanolic root and aerial part extracts from Echium arenarium Guss suppress proliferation and induce apoptosis of multiple myeloma cells through mitochondrial pathway Environ. Toxicol. (IF 3.118) Pub Date : 2021-01-04 Inès Limam, Fatma Ben Aissa‐Fennira, Rim Essid, Ahlem Chahbi, Sarra Kefi, Khaoula Mkadmini, Salem Elkahoui, Mohamed Abdelkarim
Echium arenarium Guss is a Mediterranean plant traditionally used in healing skin wound and it was reported exhibiting potent antioxidant, antibacterial, and antiparasitic activities. However, antitumoral activities of this plant have not yet been explored. Here we investigated for the first time, root (EARE) and aerial part (EAAPE) extracts of E. arenarium Guss to examine cytotoxicity and apoptosis
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Ras/Raf/MEK/ERK pathway axis mediated neurotoxicity induced by high‐risk pesticide residue‐Avermectin Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-31 Ting Zhu, Xu Liu, Jian Song, Dong Li, Xiao‐Jing Pang, Sheng‐Hui Wang, Qing‐Rong Li, Dong‐Jun Fu, Sai‐Yang Zhang, Han‐Zhong Xie
Pesticide residues have become a healthy threaten of human beings. Among the pesticides, many of them have neurotoxicity. Extracellular Regulated Protein Kinases (ERK) pathway is an important signaling pathway that regulates a variety of downstream progress. In this work, peach (PRUNUS persica) and cherry (PRUNUS cerasus) were sampled from over 300 plantations in China and assessed for the residue
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Responses of Cirrhinus mrigala to second‐generation fluoroquinolone (ciprofloxacin) toxicity: Assessment of antioxidants, tissue morphology, and inorganic ions Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-31 Mathan Ramesh, Madhavan Sujitha, Pottanthara Ashokan Anila, Zongming Ren, Rama Krishnan Poopal
Ciprofloxacin drugs are a second‐generation fluoroquinolone highly prescribed medication against various bacterial infections in human and aquaculture practices. These drugs are chemically designed to persist in the body long enough to achieve target objectives. Extensive usage has resulted in ciprofloxacin becoming a ubiquitous contaminant in the environment. Unfortunately, the ecotoxicological profiles
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6,8‐Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53 Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-31 Yong Jun Choi, Jongsung Lee, Sang Hoon Ha, Han Ki Lee, Heui Min Lim, Seon‐Hak Yu, Chang Min Lee, Myeong Jin Nam, Yung‐Hun Yang, Kyungmoon Park, Youn Soo Choi, Kyu Yun Jang, See‐Hyoung Park
6,8‐Diprenylorobol is a natural compound mainly found in Glycyrrhiza uralensis fisch and Maclura tricuspidata, which has been used traditionally as food and medicine in Asia. So far, the antiproliferative effect of 6,8‐diprenylorobol has not been studied yet in colon cancer. In this study, we aimed to evaluate the antiproliferative effects of 6,8‐diprenylorobol in LoVo and HCT15, two kinds of human
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The role of H3K9me2‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba extract intervention Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-30 Xuejiao Ding, Anliu Zhang, Changzhe Li, Lu Ma, Shunfang Tang, Qi Wang, Guanghong Yang, Jun Li
Arsenic is an established human carcinogen that can induce DNA damage; however, the precise mechanism remains unknown. Histone modification is of great significance in chemical toxicity and carcinogenesis. To investigate the role of histone H3K9me2 in arsenic‐induced DNA damage, HaCaT cells were exposed to sodium arsenite in this study, and the results showed that the enrichment level of H3K9me2 at
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Effects of benzo(a)pyrene at environmentally relevant doses on embryo‐fetal development in rats Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-22 Suyane da Silva Moreira, Leonardo Cesar de Lima Inocêncio, Bárbara Campos Jorge, Ana Carolina Casali Reis, Hamilton Hisano, Arielle Cristina Arena
Studies have demonstrated that Benzo(a)Pyrene (BaP), a polycyclic aromatic hydrocarbon ubiquituous in the environment, can cause teratogenic effects. Since the majority of studies used in vitro models or high doses of BaP, this study evaluated the teratogenicity, reproductive and developmental performance of low doses of BaP through maternal and fetus examination after daily oral administration of
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Genistein enhances the effects of L‐asparaginase on inducing cell apoptosis in human leukemia cancer HL‐60 cells Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-21 Yin‐Chen Hsiao, Fu‐Shin Chueh, Yi‐Shih Ma, Jin‐Cherng Lien, Te‐Chun Hsia, Wen‐Wen Huang, Yu‐Cheng Chou, Po‐Yuan Chen, Jing‐Gung Chung, Hung‐Yi Chen, Kuo‐Ching Liu
Genistein (GEN) has been shown to induce apoptotic cell death in various human cancer cells. L‐asparaginase (Asp), a clinical drug for leukemia, has been shown to induce cell apoptosis in leukemia cells. No available information concerning GEN combined with Asp increased the cell apoptosis compared to GEN or Asp treatment alone. The objective of this study is to evaluate the anti‐leukemia activity
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Chemopreventive effect of dieckol against 7,12‐dimethylbenz(a)anthracene induced skin carcinogenesis model by modulatory influence on biochemical and antioxidant biomarkers Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-21 Wenming Xiao, Hongyan Liu, Ying Lei, Huawei Gao, Tahani Awad Alahmadi, Haitao Peng, Wei Chen
Skin cancer is the commonly found type, which contributes to 40% of whole cancer incidences worldwide. Dieckol is an active compound occurs in the marine algae with many biological benefits. In this exploration, we intended to investigate the therapeutic potency of dieckol against the 7,12‐dimethylbenz(a)anthracene (DMBA)‐triggered skin carcinogenesis in mice. The skin cancer was stimulated to the
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Long noncoding RNA DUXAP10 promotes the stemness of glioma cells by recruiting HuR to enhance Sox12 mRNA stability Environ. Toxicol. (IF 3.118) Pub Date : 2020-12-19 Bolin Wu, Chengyou Yang, Yuefeng Fang, Weilong Ding, Yuqing Zhang
Long noncoding RNA (lncRNA) DUXAP10 has been shown to act as an oncogene in various tumors; however, its roles in glioma progression have never been established. Here, we show that DUXAP10 is overexpressed in glioma tissues and cells. Loss of function experiments reveal that DUXAP10 knockdown has little effects on glioma cell viability, but significantly reduces the stemness of glioma cells, which
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