-
Associations between Blood Lead Levels and Coronary Artery Stenosis Measured Using Coronary Computed Tomography Angiography Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-23 Suwhan Kim; Wonyang Kang; Seunghyeon Cho; Dae-Young Lim; Yeongjae Yoo; Ryoung Jin Park; Byung Chan Lee; Jai-Dong Moon; Won-Ju Park
Abstract Background: Lead exposure is a risk factor for increased blood pressure and cardiovascular disease, even when blood lead levels (BLLs) are within the normal range. Objective: This study aimed to investigate the association between BLL and coronary artery stenosis (CAS) in asymptomatic adults using 128-slice dual-source coronary computed tomography (CT) angiography. Methods: We analyzed medical
-
Environmental Spread of Extended Spectrum Beta-Lactamase (ESBL) Producing Escherichia coli and ESBL Genes among Children and Domestic Animals in Ecuador Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-22 Liseth Salinas; Fernanda Loayza; Paúl Cárdenas; Carlos Saraiva; Timothy J. Johnson; Heather Amato; Jay P. Graham; Gabriel Trueba
Abstract Background: There is a significant gap in our understanding of the sources of multidrug-resistant bacteria and resistance genes in community settings where human–animal interfaces exist. Objectives: This study characterized the relationship of third-generation cephalosporin-resistant Escherichia coli (3GCR-EC) isolated from animal feces in the environment and child feces based on phenotypic
-
Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-19 Elvis Ticiani; Jeremy Gingrich; Yong Pu; Mathew Vettathu; Jacquelyn Davis; Denny Martin; Margaret G. Petroff; Almudena Veiga-Lopez
Abstract Background: Bisphenol S (BPS) is an endocrine-disrupting chemical and the second most abundant bisphenol detected in humans. In vivo BPS exposure leads to reduced binucleate cell number in the ovine placenta. Binucleate cells form by cellular fusion, similar to the human placental syncytiotrophoblast layer. Given that human placental syncytialization can be stimulated through epidermal growth
-
Air Pollution and Polyclonal Elevation of Serum Free Light Chains: An Assessment of Adaptive Immune Responses in the Prospective Heinz Nixdorf Recall Study Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-17 Simone Ohlwein; Frauke Hennig; Sarah Lucht; Börge Schmidt; Lewin Eisele; Marina Arendt; Ulrich Dührsen; Jan Dürig; Karl-Heinz Jöckel; Susanne Moebus; Barbara Hoffmann
Abstract Background: Residential exposure to air pollution (AP) has been shown to activate the immune system (IS). Although innate immune responses to AP have been studied extensively, investigations on the adaptive IS are scarce. Objectives: The aim of this study was to investigate the association between short- to long-term AP exposure and polyclonal free light chains (FLC) produced by plasma cells
-
Regulating PFAS as a Chemical Class under the California Safer Consumer Products Program Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-17 Simona Andreea Bălan; Vivek Chander Mathrani; Dennis Fengmao Guo; André Maurice Algazi
Abstract Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a group of manmade chemicals containing at least one fully fluorinated carbon atom. The widespread use, large number, and diverse chemical structures of PFAS pose challenges to any sufficiently protective regulation, emissions reduction, and remediation at contaminated sites. Regulating only a subset of PFAS has led to their
-
Participatory Research for Environmental Justice: A Critical Interpretive Synthesis Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-16 Leona F. Davis; Mónica D. Ramírez-Andreotta
Abstract Background: Environmental health risks are disproportionately colocated with communities in poverty and communities of color. In some cases, participatory research projects have effectively addressed structural causes of health risk in environmental justice (EJ) communities. However, many such projects fail to catalyze change at a structural level. Objectives: This review employs Critical
-
PM2.5 Concentration and Composition in Subway Systems in the Northeastern United States Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-10 David G. Luglio; Maria Katsigeorgis; Jade Hess; Rebecca Kim; John Adragna; Amna Raja; Colin Gordon; Jonathan Fine; George Thurston; Terry Gordon; M.J. Ruzmyn Vilcassim
Abstract Objectives: The goals of this study were to assess the air quality in subway systems in the northeastern United States and estimate the health risks for transit workers and commuters. Methods: We report real-time and gravimetric PM2.5 concentrations and particle composition from area samples collected in the subways of Philadelphia, Pennsylvania; Boston, Massachusetts; New York City, New York/New
-
Fine Particle Exposure and Clinical Aggravation in Neurodegenerative Diseases in New York State Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-8 Yanelli Nunez; Amelia K. Boehme; Marc G. Weisskopf; Diane B. Re; Ana Navas-Acien; Aaron van Donkelaar; Randall V. Martin; Marianthi-Anna Kioumourtzoglou
Abstract Background: Adult-onset neurodegenerative diseases affect millions and negatively impact health care systems worldwide. Evidence suggests that air pollution may contribute to aggravation of neurodegeneration, but studies have been limited. Objective: We examined the potential association between long-term exposure to particulate matter ≤2.5μm in aerodynamic diameter [fine particulate matter
-
Prenatal Exposure to Nitrate from Drinking Water and Markers of Fetal Growth Restriction: A Population-Based Study of Nearly One Million Danish-Born Children Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-4 Vanessa R. Coffman; Anja Søndergaard Jensen; Betina B. Trabjerg; Carsten B. Pedersen; Birgitte Hansen; Torben Sigsgaard; Jørn Olsen; Inger Schaumburg; Jörg Schullehner; Marie Pedersen; Leslie T. Stayner
Abstract Background: High levels of nitrate (NO3−) in drinking water cause methemoglobinemia in infants; however, few studies have examined the potential effects of low-level exposure on fetal growth, and the results have been inconsistent. Objectives: We sought to assess the association between maternal exposure to nitrate in drinking water during pregnancy and offspring size at birth in a nationwide
-
Potential Mechanisms behind Air Pollution Toxicity: Findings from Real-World Chronic Exposures Environ. Health Perspect. (IF 8.382) Pub Date : 2021-2-1 Florencia Pascual
Abstract
-
NO2 and PM2.5 Exposures and Lung Function in Swiss Adults: Estimated Effects of Short-Term Exposures and Long-Term Exposures with and without Adjustment for Short-Term Deviations Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-27 Alexandra Strassmann; Kees de Hoogh; Martin Röösli; Sarah R. Haile; Alexander Turk; Matthias Bopp; Milo A. Puhan; for the Swiss National Cohort Study Group
Abstract Background: The impact of nitrogen dioxide (NO2) and particulate matter with an aerodynamic diameter of less than or equal to 2.5. microns (PM2.5) exposures on lung function has been investigated mainly in children and less in adults. Furthermore, it is unclear whether short-term deviations of air pollutant concentration need to be considered in long-term exposure models. Objectives: The aims
-
Use of Shotgun Metagenomics and Metabolomics to Evaluate the Impact of Glyphosate or Roundup MON 52276 on the Gut Microbiota and Serum Metabolome of Sprague-Dawley Rats Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-27 Robin Mesnage; Maxime Teixeira; Daniele Mandrioli; Laura Falcioni; Quinten Raymond Ducarmon; Romy Daniëlle Zwittink; Francesca Mazzacuva; Anna Caldwell; John Halket; Caroline Amiel; Jean-Michel Panoff; Fiorella Belpoggi; Michael Nicolas Antoniou
Abstract Background: There is intense debate on whether glyphosate can inhibit the shikimate pathway of gastrointestinal microorganisms, with potential health implications. Objectives: We tested whether glyphosate or its representative EU herbicide formulation Roundup MON 52276 affects the rat gut microbiome. Methods: We combined cecal microbiome shotgun metagenomics with serum and cecum metabolomics
-
Redlines and Greenspace: The Relationship between Historical Redlining and 2010 Greenspace across the United States Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-27 Anthony Nardone; Kara E. Rudolph; Rachel Morello-Frosch; Joan A. Casey
Abstract Introduction: Redlining, a racist mortgage appraisal practice of the 1930s, established and exacerbated racial residential segregation boundaries in the United States. Investment risk grades assigned >80y ago through security maps from the Home Owners’ Loan Corporation (HOLC) are associated with current sociodemographics and adverse health outcomes. We assessed whether historical HOLC investment
-
Exposure of Adult Female Mice to Low Doses of di(2-ethylhexyl) Phthalate Alone or in an Environmental Phthalate Mixture: Evaluation of Reproductive Behavior and Underlying Neural Mechanisms Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-27 Nolwenn Adam; Linda Brusamonti; Sakina Mhaouty-Kodja
Abstract Background: We have previously shown that adult male mice exposure to low doses of an ubiquitous endocrine disruptor, di(2-ethylhexyl) phthalate (DEHP), alters courtship behavior. Objective: The effects of adult exposure to low doses of DEHP alone or in an environmental phthalate mixture on estrous cyclicity, reproductive behavior, and underlying neural structures were analyzed in female mice
-
DNA Methylation Patterns in CD4+ T Cells of Naïve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-15 Catherine G. Burke; Jason R. Myers; Christina M. Post; Lisbeth A. Boulé; B. Paige Lawrence
Abstract Background: Early life environmental exposures can have lasting effects on the function of the immune system and contribute to disease later in life. Epidemiological studies have linked early life exposure to xenobiotics that bind the aryl hydrocarbon receptor (AhR) with dysregulated immune responses later in life. Among the immune cells influenced by developmental activation of the AhR are
-
Mouse Lung Structure and Function after Long-Term Exposure to an Atmospheric Carbon Dioxide Level Predicted by Climate Change Modeling Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-13 Alexander N. Larcombe; Melissa G. Papini; Emily K. Chivers; Luke J. Berry; Robyn M. Lucas; Caitlin S. Wyrwoll
Abstract Background: Climate change models predict that atmospheric carbon dioxide [CO2] levels will be between 700 and 900 ppm within the next 80 y. Despite this, the direct physiological effects of exposure to slightly elevated atmospheric CO2 (as compared with ∼410 ppm experienced today), especially when exposures extend from preconception to adulthood, have not been thoroughly studied. Objectives:
-
Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin—A Human Experimental Study Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-13 Emelie Rietz Liljedahl; Gunnar Johanson; Helena Korres de Paula; Moosa Faniband; Eva Assarsson; Margareta Littorin; Malin Engfeldt; Carola Lidén; Anneli Julander; Karin Wahlberg; Christian Lindh; Karin Broberg
Abstract Background: The filaggrin protein is important for skin barrier structure and function. Loss-of-function (null) mutations in the filaggrin gene FLG may increase dermal absorption of chemicals. Objective: The objective of the study was to clarify if dermal absorption of chemicals differs depending on FLG genotype. Method: We performed a quantitative real-time polymerase chain reaction (qPCR)-based
-
From the Ground up: Assessing Bacterial Diversity in the Air Space of an Urban Park Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-11 Janet L. Pelley
Abstract
-
Implications of Insecticide-Treated Mosquito Net Fishing in Lower Income Countries Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-8 David A. Larsen; Joseph Makaure; Sadie J. Ryan; Donald Stewart; Adrianne Traub; Rick Welsh; Deirdre H. Love; Joseph H. BisesiJr
Abstract Introduction: Insecticide-treated mosquito nets (ITNs) are highly effective for the control of malaria. Yet widely distributed ITNs have been repurposed as fishing nets throughout the world. Objectives: Herein we present a synthesis of the current knowledge of ITN fishing and the toxicity of pyrethroids and discuss the potential implications of widespread fishing with ITNs. We further review
-
Lifetime Pesticide Use and Monoclonal Gammopathy of Undetermined Significance in a Prospective Cohort of Male Farmers Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-6 Jonathan N. Hofmann; Laura E. Beane Freeman; Kazunori Murata; Gabriella Andreotti; Joseph J. Shearer; Katie Thoren; Lakshmi Ramanathan; Christine G. Parks; Stella Koutros; Catherine C. Lerro; Danping Liu; Nathaniel Rothman; Charles F. Lynch; Barry I. Graubard; Dale P. Sandler; Michael C. Alavanja; Ola Landgren
Abstract Background: Farmers have a higher incidence of multiple myeloma, and there is suggestive evidence of an elevated prevalence of its precursor, monoclonal gammopathy of undetermined significance (MGUS), relative to the general population. Pesticide exposures are suspected to play a role; however, the biologic plausibility for associations with multiple myeloma remains unclear. Objectives: Our
-
Risk Characterization and Probabilistic Concentration–Response Modeling of Complex Environmental Mixtures Using New Approach Methodologies (NAMs) Data from Organotypic in Vitro Human Stem Cell Assays Environ. Health Perspect. (IF 8.382) Pub Date : 2021-1-4 Nan-Hung Hsieh; Zunwei Chen; Ivan Rusyn; Weihsueh A. Chiu
Abstract Background: Risk assessment of chemical mixtures or complex substances remains a major methodological challenge due to lack of available hazard or exposure data. Therefore, risk assessors usually infer hazard or risk from data on the subset of constituents with available toxicity values. Objectives: We evaluated the validity of the widely used traditional mixtures risk assessment paradigms
-
Toward Better Estimates of the Cost of Climate Change Mitigation: Guidelines for Studying Potential Health Benefits Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-29 Wendee Nicole
Abstract
-
Community Approaches for Integrating Environmental Exposures into Human Models of Disease Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-28 Anne E. Thessen; Cynthia J. Grondin; Resham D. Kulkarni; Susanne Brander; Lisa Truong; Nicole A. Vasilevsky; Tiffany J. Callahan; Lauren E. Chan; Brian Westra; Mary Willis; Sarah E. Rothenberg; Annie M. Jarabek; Lyle Burgoon; Susan A. Korrick; Melissa A. Haendel
Abstract Background: A critical challenge in genomic medicine is identifying the genetic and environmental risk factors for disease. Currently, the available data links a majority of known coding human genes to phenotypes, but the environmental component of human disease is extremely underrepresented in these linked data sets. Without environmental exposure information, our ability to realize precision
-
Knowledge Organization Systems for Systematic Chemical Assessments Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-24 Paul Whaley; Stephen W. Edwards; Andrew Kraft; Kate Nyhan; Andrew Shapiro; Sean Watford; Steve Wattam; Taylor Wolffe; Michelle Angrish
Abstract Background: Although the implementation of systematic review and evidence mapping methods stands to improve the transparency and accuracy of chemical assessments, they also accentuate the challenges that assessors face in ensuring they have located and included all the evidence that is relevant to evaluating the potential health effects an exposure might be causing. This challenge of information
-
Prenatal Exposure to Per- and Polyfluoroalkyl Substances, Umbilical Cord Blood DNA Methylation, and Cardio-Metabolic Indicators in Newborns: The Healthy Start Study Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-24 Anne P. Starling; Cuining Liu; Guannan Shen; Ivana V. Yang; Katerina Kechris; Sarah J. Borengasser; Kristen E. Boyle; Weiming Zhang; Harry A. Smith; Antonia M. Calafat; Richard F. Hamman; John L. Adgate; Dana Dabelea
Abstract Background: Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals widely detected in women of reproductive age. Prenatal PFAS exposure is associated with adverse health outcomes in children. We hypothesized that DNA methylation changes may result from prenatal PFAS exposure and may be linked to offspring cardio-metabolic phenotype. Objectives: We estimated associations
-
Microplastic Contamination of Seafood Intended for Human Consumption: A Systematic Review and Meta-Analysis Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-23 Evangelos Danopoulos; Lauren C. Jenner; Maureen Twiddy; Jeanette M. Rotchell
Abstract Background: Microplastics (MPs) have contaminated all compartments of the marine environment including biota such as seafood; ingestion from such sources is one of the two major uptake routes identified for human exposure. Objectives: The objectives were to conduct a systematic review and meta-analysis of the levels of MP contamination in seafood and to subsequently estimate the annual human
-
Interaction between Long-Term Exposure to Fine Particulate Matter and Physical Activity, and Risk of Cardiovascular Disease and Overall Mortality in U.S. Women Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-23 Elise G. Elliott; Francine Laden; Peter James; Eric B. Rimm; Kathryn M. Rexrode; Jaime E. Hart
Abstract Background: Increased respiration during physical activity may increase air pollution dose, which may attenuate the benefits of physical activity on cardiovascular disease (CVD) risk and overall mortality. Objectives: We aimed to examine the multiplicative interaction between long-term ambient residential exposure to fine particulate matter <2.5 microns (PM2.5) and physical activity in the
-
Association of Long-Term Air Pollution with Prevalence and Incidence of Distal Sensorimotor Polyneuropathy: KORA F4/FF4 Study Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-23 Christian Herder; Alexandra Schneider; Siqi Zhang; Kathrin Wolf; Haifa Maalmi; Cornelia Huth; Regina Pickford; Michael Laxy; Gidon J. Bönhof; Wolfgang Koenig; Wolfgang Rathmann; Michael Roden; Annette Peters; Barbara Thorand; Dan Ziegler
Abstract Background: Air pollution contributes to type 2 diabetes and cardiovascular diseases, but its relevance for other complications of diabetes, in particular distal sensorimotor polyneuropathy (DSPN), is unclear. Recent studies have indicated that DSPN is also increasingly prevalent in obesity. Objectives: We aimed to assess associations of air pollutants with prevalent and incident DSPN in a
-
The Association between Residential Green Space in Childhood and Development of Attention Deficit Hyperactivity Disorder: A Population-Based Cohort Study Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-22 Malene Thygesen; Kristine Engemann; Gitte J. Holst; Birgitte Hansen; Camilla Geels; Jørgen Brandt; Carsten B. Pedersen; Søren Dalsgaard
Abstract Background: Access to green space has been hypothesized to have a beneficial impact on children’s mental well-being and cognitive development. The underlying mechanisms of the mental health benefits of green space are not fully understood, but different pathways have been suggested, such as the psychologically restoring capacities of green space, the ability to facilitate physical activity
-
Developmental Neurotoxicity of Domoic Acid: Evidence for a Critical Window of Exposure Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-21 Silke Schmidt
Abstract
-
Folic Acid Supplementation and the Association between Maternal Airborne Particulate Matter Exposure and Preterm Delivery: A National Birth Cohort Study in China Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-18 Qin Li; Yuan-Yuan Wang; Yuming Guo; Hong Zhou; Xiaobin Wang; Qiao-Mei Wang; Hai-Ping Shen; Yi-Ping Zhang; Dong-Hai Yan; Shanshan Li; Gongbo Chen; Lizi Lin; Yuan He; Ying Yang; Zuo-Qi Peng; Hai-Jun Wang; Xu Ma
Abstract Background: Potential modification of the association between maternal particulate matter (PM) exposure and preterm delivery (PTD) by folic acid (FA) supplementation has not been studied. Objective: We examined whether FA supplementation could reduce the risk of PTD associated with maternal exposure to PM in ambient air during pregnancy. Method: In a cohort study covering 30 of the 31 provinces
-
Urinary Arsenic and Cadmium Associations with Findings from Cranial MRI in American Indians: Data from the Strong Heart Study Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-17 Astrid Suchy-Dicey; Carolyn Noonan; Ekaterina Burduli; Farrah J. Mateen; W.T. LongstrethJr.; Dedra Buchwald; Ana Navas-Acien
Abstract Background: Arsenic and cadmium are known cardiovascular toxicants that pose disproportionate risk to rural communities where environmental exposures are high. American Indians have high vascular risk, which may be attributable in part to these exposures. Objective: We examined urine metal concentrations in association with magnetic resonance imaging findings of vascular brain injury or cerebral
-
Environmental Cadmium and Mortality from Influenza and Pneumonia in U.S. Adults Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-16 Sung Kyun Park; Coralynn Sack; Matti J. Sirén; Howard Hu
Abstract Background: Environmental cadmium exposure is widespread. In humans, cadmium is poorly excreted, triggers pulmonary inflammation, reduces pulmonary function, and enhances lung injury by respiratory syncytial virus. Objectives: We examined the association of cadmium burden with mortality related to influenza or pneumonia. Methods: This prospective analysis of the National Health and Nutrition
-
Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-16 Min Liu; Shenglan Jia; Ting Dong; Fanrong Zhao; Tengfei Xu; Qin Yang; Jicheng Gong; Mingliang Fang
Abstract Background: Humans are constantly being exposed to various xenobiotics at relatively low concentrations. To date, limited evidence is available to ascertain whether a complex xenobiotic mixture at human-relevant levels causes any health effect. Moreover, there is no effective method to pinpoint the contribution of each chemical toward such an effect. Objectives: This study aims to understand
-
A Case-Crossover Analysis of Indoor Heat Exposure on Mortality and Hospitalizations among the Elderly in Houston, Texas Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-10 Cassandra R. O’Lenick; Amir Baniassadi; Ryan Michael; Andrew Monaghan; Jennifer Boehnert; Xiao Yu; Mary H. Hayden; Christine Wiedinmyer; Kai Zhang; Peter J. Crank; Jannik Heusinger; Paige Hoel; David J. Sailor; Olga V. Wilhelmi
Abstract Background: Despite the substantial role indoor exposure has played in heat wave–related mortality, few epidemiological studies have examined the health effects of exposure to indoor heat. As a result, knowledge gaps regarding indoor heat–health thresholds, vulnerability, and adaptive capacity persist. Objective: We evaluated the role of indoor heat exposure on mortality and morbidity among
-
Inequalities in Public Water Arsenic Concentrations in Counties and Community Water Systems across the United States, 2006–2011 Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-9 Anne E. Nigra; Qixuan Chen; Steven N. Chillrud; Lili Wang; David Harvey; Brian Mailloux; Pam Factor-Litvak; Ana Navas-Acien
Abstract Background: In the United States, nationwide estimates of public drinking water arsenic exposure are not readily available. We used the U.S. Environmental Protection Agency’s (EPA) Six-Year Review contaminant occurrence data set to estimate public water arsenic exposure. We compared community water system (CWS) arsenic concentrations during 2006–2008 vs. after 2009–2011, the initial monitoring
-
Low-Dose Bisphenol A in a Rat Model of Endometrial Cancer: A CLARITY-BPA Study Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-9 Yuet-Kin Leung; Jacek Biesiada; Vinothini Govindarajah; Jun Ying; Ady Kendler; Mario Medvedovic; Shuk-Mei Ho
Abstract Background: Bisphenol A (BPA) is known to be biologically active in experimental models even at low levels of exposure. However, its impact on endometrial cancer remains unclear. Objectives: This study aimed to investigate whether lifelong exposure to different doses of BPA induced uterine abnormalities and molecular changes in a rat model. Methods: Sprague-Dawley rats were exposed to 5 doses
-
In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-9 Samia Selmi-Ruby; Jesús Marín-Sáez; Aurélie Fildier; Audrey Buleté; Myriam Abdallah; Jessica Garcia; Julie Deverchère; Loïc Spinner; Barbara Giroud; Sébastien Ibanez; Thierry Granjon; Claire Bardel; Alain Puisieux; Béatrice Fervers; Emmanuelle Vulliet; Léa Payen; Arnaud M. Vigneron
Abstract Background: Aryl phosphate esters (APEs) are widely used and commonly present in the environment. Health hazards associated with these compounds remain largely unknown and the effects of diphenyl phosphate (DPhP), one of their most frequent derivatives, are poorly characterized. Objective: Our aim was to investigate whether DPhP per se may represent a more relevant marker of exposure to APEs
-
Tropical Cyclone Exposures and Health: A New Data Set to Assess Associations over Time Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-8 Lindsey Konkel
Abstract
-
Understanding the Impact of Rainfall on Diarrhea: Testing the Concentration-Dilution Hypothesis Using a Systematic Review and Meta-Analysis Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-7 Alicia N. M. Kraay; Olivia Man; Morgan C. Levy; Karen Levy; Edward Ionides; Joseph N. S. Eisenberg
Abstract Background: Projected increases in extreme weather may change relationships between rain-related climate exposures and diarrheal disease. Whether rainfall increases or decreases diarrhea rates is unclear based on prior literature. The concentration-dilution hypothesis suggests that these conflicting results are explained by the background level of rain: Rainfall following dry periods can flush
-
Boiled or Bottled: Regional and Seasonal Exposures to Drinking Water Contamination and Household Air Pollution in Rural China Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-4 Alasdair Cohen; Ajay Pillarisetti; Qing Luo; Qi Zhang; Hongxing Li; Gemei Zhong; Gang Zhu; John M. ColfordJr.; Kirk R. Smith; Isha Ray; Yong Tao
Abstract Background: Inadequate access to safe drinking water remains a global health problem, particularly in rural areas. Boiling is the most commonly used form of point-of-use household water treatment (HWT) globally, although the use of bottled water in low- and middle-income countries (LMICs) is increasing rapidly. Objectives: We assessed the regional and seasonal prevalence of HWT practices (including
-
Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution Environ. Health Perspect. (IF 8.382) Pub Date : 2020-12-4 Sabrina Edwards; Gang Zhao; Joanne Tran; Kelley T. Patten; Anthony Valenzuela; Christopher Wallis; Keith J. Bein; Anthony S. Wexler; Pamela J. Lein; Xiaoquan Rao
Abstract Background: Traffic-related air pollution (TRAP) is made up of complex mixtures of particulate matter, gases and volatile compounds. However, the effects of TRAP on the cardiopulmonary system in most animal studies have been tested using acute exposure to singular pollutants. The cardiopulmonary effects and molecular mechanisms in animals that are chronically exposed to unmodified air pollution
-
Air of Uncertainty: Can We Study Pollution and COVID-19 in the Midst of a Pandemic? Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-30 Wendee Nicole
Abstract
-
Repetitive Ozone Exposures and Evaluation of Pulmonary Inflammation and Remodeling in Diabetic Mouse Strains Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-30 James G. Wagner; Christina E. Barkauskas; Aaron Vose; Ryan P. Lewandowski; Jack R. Harkema; Robert M. Tighe
Abstract Background: Epidemiological studies support the hypothesis that diabetes alters pulmonary responses to air pollutants like ozone (O3). The mechanism(s) underlying these associations and potential links among diabetes, O3, and lung inflammation and remodeling are currently unknown. Objectives: The goal was to determine whether pulmonary responses to repetitive ozone exposures are exacerbated
-
Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-25 Martin Scholze; Camilla Taxvig; Andreas Kortenkamp; Julie Boberg; Sofie Christiansen; Terje Svingen; Karin Lauschke; Henrik Frandsen; Sibylle Ermler; Susan Strange Hermann; Mikael Pedersen; Anne Kruse Lykkeberg; Marta Axelstad; Anne Marie Vinggaard
Abstract Background: Many pesticides can antagonize the androgen receptor (AR) or inhibit androgen synthesis in vitro but their potential to cause reproductive toxicity related to disruption of androgen action during fetal life is difficult to predict. Currently no approaches for using in vitro data to anticipate such in vivo effects exist. Prioritization schemes that limit unnecessary in vivo testing
-
Vertical Stratification in Urban Green Space Aerobiomes Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-25 Jake M. Robinson; Christian Cando-Dumancela; Craig Liddicoat; Philip Weinstein; Ross Cameron; Martin F. Breed
Abstract Background: Exposure to a diverse environmental microbiome is thought to play an important role in “educating” the immune system and facilitating competitive exclusion of pathogens to maintain human health. Vegetation and soil are key sources of airborne microbiota––the aerobiome. A limited number of studies have attempted to characterize the dynamics of near surface green space aerobiomes
-
On Wells and Wellness: Oil and Gas Flaring as a Potential Risk Factor for Preterm Birth Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-23 Wendee Nicole
Abstract
-
Vitamin D Treatment during Pregnancy and Maternal and Neonatal Cord Blood Metal Concentrations at Delivery: Results of a Randomized Controlled Trial in Bangladesh Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-23 Anne Marie Z. Jukic; Anna Zuchniak; Huma Qamar; Tahmeed Ahmed; Abdullah Al Mahmud; Daniel E. Roth
Abstract Background: Vitamin D improves absorption of calcium; however, in animal studies vitamin D also increases the absorption of toxic metals, such as lead and cadmium. Objectives: We examined maternal and neonatal cord blood levels of lead, cadmium, manganese, and mercury after supplementation with vitamin D during pregnancy. Methods: The Maternal Vitamin D for Infant Growth trial was a randomized
-
Long-Term Ambient Air Pollution Exposures and Brain Imaging Markers in Korean Adults: The Environmental Pollution-Induced Neurological EFfects (EPINEF) Study Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-20 Jaelim Cho; Young Noh; Sun Young Kim; Jungwoo Sohn; Juhwan Noh; Woojin Kim; Seong-Kyung Cho; Hwasun Seo; Gayoung Seo; Seung-Koo Lee; Seongho Seo; Sang-Baek Koh; Sung Soo Oh; Hee Jin Kim; Sang Won Seo; Dae-Seock Shin; Nakyoung Kim; Ho Hyun Kim; Jung Il Lee; Changsoo Kim
Abstract Background: Only a limited number of neuroimaging studies have explored the effects of ambient air pollution in adults. The prior studies have investigated only cortical volume, and they have reported mixed findings, particularly for gray matter. Furthermore, the association between nitrogen dioxide (NO2) and neuroimaging markers has been little studied in adults. Objectives: We investigated
-
Depot Medroxyprogesterone Acetate Use and Blood Lead Levels in a Cohort of Young Women Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-18 Kristen Upson; Quaker E. Harmon; Renee Heffron; Janet E. Hall; Lauren A. Wise; Ganesa Wegienka; Erik J. Tokar; Donna D. Baird
Abstract Background: Injectable contraceptive use is common, with 74 million users worldwide. Use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) is associated with bone mineral density loss. We hypothesize that increased bone resorption with DMPA use allows for mobilization of the toxic metal lead stored in bone to blood, presenting users with increased systemic exposure to
-
Polychlorinated Biphenyls as a Cardiovascular Health Risk: A New Threat from an Old Enemy? Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-17 Florencia Pascual
Abstract
-
Assessing the Ability of Developmentally Precocious Estrogen Signaling to Recapitulate Ovarian Transcriptomes and Follicle Dynamics in Alligators from a Contaminated Lake Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-13 Matthew D. Hale; Benjamin B. Parrott
Abstract Background: Concern has grown in recent decades over anthropogenic contaminants that interfere with the functioning of endocrine hormones. However, mechanisms connecting developmental processes to pathologies associated with endocrine-disrupting chemical (EDC) exposure are poorly understood in naturally exposed populations. Objectives: We sought to a) characterize divergence in ovarian transcriptomic
-
Breaking It Down: Estimating Short-Chain PFAS Half-Lives in a Human Population Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-11 Wendee Nicole
Abstract
-
Guidelines for Modeling and Reporting Health Effects of Climate Change Mitigation Actions Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-10 Jeremy J. Hess; Nikhil Ranadive; Chris Boyer; Lukasz Aleksandrowicz; Susan C. Anenberg; Kristin Aunan; Kristine Belesova; Michelle L. Bell; Sam Bickersteth; Kathryn Bowen; Marci Burden; Diarmid Campbell-Lendrum; Elizabeth Carlton; Guéladio Cissé; Francois Cohen; Hancheng Dai; Alan David Dangour; Purnamita Dasgupta; Howard Frumkin; Peng Gong; Robert J. Gould; Andy Haines; Simon Hales; Ian Hamilton;
Abstract Background: Modeling suggests that climate change mitigation actions can have substantial human health benefits that accrue quickly and locally. Documenting the benefits can help drive more ambitious and health-protective climate change mitigation actions; however, documenting the adverse health effects can help to avoid them. Estimating the health effects of mitigation (HEM) actions can help
-
Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-4 Jennifer M. Panlilio; Neelakanteswar Aluru; Mark E. Hahn
Abstract Background: Harmful algal blooms (HABs) produce potent neurotoxins that threaten human health, but current regulations may not be protective of sensitive populations. Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behavioral deficits in rodent and primate models; however, the mechanisms involved are unknown. The zebrafish is a powerful in vivo vertebrate
-
Dust Storms and Human Health: A Call for More Consistent, Higher-Quality Studies Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-3 Carrie Arnold
Abstract
-
Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles Environ. Health Perspect. (IF 8.382) Pub Date : 2020-11-3 Caitlin G. Howe; Birgit Claus Henn; Sandrah P. Eckel; Shohreh F. Farzan; Brendan H. Grubbs; Thomas A. Chavez; Tahlia L. Hodes; Dema Faham; Laila Al-Marayati; Deborah Lerner; Alyssa Quimby; Sara Twogood; Michael J. Richards; John D. Meeker; Theresa M. Bastain; Carrie V. Breton
Abstract Background: Reduced fetal growth increases the risk for adverse health outcomes. Growing evidence suggests that metal exposures contribute to reduced fetal growth, but little is known about the effects of complex metal mixtures. Objectives: We investigated the impact of a complex mixture of metals on birth weight for gestational age (BW for GA) in the Maternal and Developmental Risks from
-
E-Cigarette Aerosols and the Brain: Behavioral and Neuroinflammatory Changes in Prenatally Exposed Adult Mice Environ. Health Perspect. (IF 8.382) Pub Date : 2020-10-26 Silke Schmidt
Abstract
-
Drivers of and Obstacles to the Adoption of Toxicogenomics for Chemical Risk Assessment: Insights from Social Science Perspectives Environ. Health Perspect. (IF 8.382) Pub Date : 2020-10-28 Guillaume Pain; Gordon Hickey; Matthieu Mondou; Doug Crump; Markus Hecker; Niladri Basu; Steven Maguire
Abstract Background: Some 20 y ago, scientific and regulatory communities identified the potential of omics sciences (genomics, transcriptomics, proteomics, metabolomics) to improve chemical risk assessment through development of toxicogenomics. Recognizing that regulators adopt new scientific methods cautiously given accountability to diverse stakeholders, the scope and pace of adoption of toxicogenomics
-
The ‘SELection End points in Communities of bacTeria’ (SELECT) Method: A Novel Experimental Assay to Facilitate Risk Assessment of Selection for Antimicrobial Resistance in the Environment Environ. Health Perspect. (IF 8.382) Pub Date : 2020-10-21 Aimee K. Murray; Isobel C. Stanton; Jessica Wright; Lihong Zhang; Jason Snape; William H. Gaze
Abstract Background: Antimicrobial resistance (AMR) is one of the most significant health threats to society. A growing body of research demonstrates selection for AMR likely occurs at environmental concentrations of antibiotics. However, no standardized experimental approaches for determining selective concentrations of antimicrobials currently exist, preventing appropriate environmental and human
Contents have been reproduced by permission of the publishers.