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A Chapter Closes at Environmental Health Perspectives. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-26 Joel D Kaufman
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Workflow for Statistical Analysis of Environmental Mixtures. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-17 Bonnie R Joubert,Glenn Palmer,David Dunson,Marianthi-Anna Kioumourtzoglou,Brent A Coull
BACKGROUND Human exposure to complex, changing, and variably correlated mixtures of environmental chemicals has presented analytical challenges to epidemiologists and human health researchers. There has been a wide variety of recent advances in statistical methods for analyzing mixtures data, with most methods having open-source software for implementation. However, there is no one-size-fits-all method
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Invited Perspective: Air Pollution and Temperature Even Affects the Placenta-Revisiting Common Approaches. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-16 Cande V Ananth,Stefania Papatheodorou
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Invited Perspective: Improving Our Approach to Studies of Outdoor Artificial Light at Night and Cancer Risk. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-16 Parveen Bhatti,Manolis Kogevinas
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Mobilization of the environmental toxicant chlorpyrifos during weight loss and its impact on liver and adipose tissue metabolism in mice. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-13 Yifan Xiang,Gaojian Tang,Xiaohu Hu,Xiaoxiao Yu,Yanrong Feng,Zhongzuo Huang,Yicheng Luo,Zongyou Jiang,Yue Lv,Xiaoying Sun,Yan Zhang,Long Cheng,Yu Xin,Yuxin Qian,Boyu Li,Bo Wang
BACKGROUND Fat-soluble toxicants such as chlorpyrifos (CPF) can accumulate in adipose tissue and the liver. During weight loss, these compounds may be released into circulation, but the metabolic consequences of this mobilization remain poorly understood. OBJECTIVES This study aimed to investigate the mobilization of CPF during weight loss and its effects on liver health and adipose tissue metabolism
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The Role of Gut Microbiota in the Association Between Air Pollution and Cognitive Function in Older Adults. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-13 Wenhao Qi,Mengmeng Kong,Xia Meng,Zhonghan Sun,Zhendong Mei,Yanni Pu,Xiaofeng Zhou,Qichu Wang,Jian-Ge Qiu,Bing-Hua Jiang,Jie Shen,Changzheng Yuan,John S Ji,Xiaofeng Wang,Haidong Kan,Yan Zheng
BACKGROUND Growing evidence links air pollution to cognitive dysfunction in older adults. The gut microbiome and circulating metabolites present an important yet unexplored pathway, given their crucial role in the gut-brain axis. OBJECTIVES We aimed to explore the potential roles of gut bacteria, fungi, microbial functional potentials, and circuiting metabolites in the association of residential
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Systematic Evidence Map for the Per- and Polyfluoroalkyl Substances (PFAS) Universe. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-12 Avanti V Shirke,Elizabeth G Radke,Ryan Jones,Barrett D Allen,Cynthia J Lin,Amanda Ross,Nicole Vetter,Courtney Lemeris,Pamela Hartman,Sorina Eftim,Arun Varghese,Robyn Blain,Heidi Hubbard,Antony J Williams,Kristina A Thayer,Laura M Carlson
BACKGROUND Per- and polyfluoroalkyl substances (PFAS) are a research priority for the U.S. Environmental Protection Agency (EPA). Because PFAS include thousands of structurally diverse chemicals, there is a pressing need for identifying what data are available to assess the human health hazard of these compounds. OBJECTIVES We used systematic evidence map (SEM) methods to summarize the available
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Deep Tubewell Use and Child Diarrhea in Rural Bangladesh: Results from a Prospective Community Surveillance Study. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-12 Varun Goel,Mia Ziade,Brianna Chan,Md Yunus,Md Taslim Ali,Md Al Fazal Khan,Md Nurul Alam,Asg Faruque,Shahabuddin Babu,Md Masnoon Kabir,Paul L Delamater,Marc L Serre,Mark D Sobsey,Md Sirajul Islam,Michael Emch
BACKGROUND Diarrheal diseases remain a leading cause of mortality and morbidity among under-five children in South Asia. In rural Bangladesh, deep tubewells that tap into low-arsenic deep aquifers have been installed to provide microbially safe and arsenic-free drinking-water at source. However, unlike more widely used shallow tubewells, deep tubwells are sparsely distributed, and households often
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Advancing Exposomics: From Concept to Practice in Environmental Health Sciences. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-12 Alison A Motsinger-Reif,David M Balshaw,Linda S Birnbaum,Yuxia Cui,Curt T DellaValle,Cinnamon A Dixon,Erin Iturriaga,David A Jett,Aubrey K Miller,Victoria K Shanmugam,Sarah M Temkin,Richard K Kwok
BACKGROUND Exposomics is a conceptual framework positioned at the intersection of environmental health sciences and precision medicine. It seeks to comprehensively understand how environmental exposures and the body's response to these exposures impact human health across the life course. Introduced in 2005, the exposome concept represents a paradigm shift from single-pollutant studies to an integrated
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Assessing the potential impacts of California Senate Bill 27 (SB27) on the antimicrobial susceptibility of Escherichia coli from raw meat. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-11 Vanessa Quinlivan,Daniel E Park,Maliha Aziz,Joan A Casey,Meghan Davis,Qi Hu,Gabriel Innes,Keeve Nachman,Ann Nyaboe,Magdalena Pomichowski,Hanna-Grace Rabanes,Annie Roberts,Erika Roloff,Harpreet S Takhar,Sara Y Tartof,Cindy Liu,Lance Price,
BACKGROUND Antimicrobial use in food-animal production selects for antimicrobial-resistant Escherichia coli (E. coli) that can be transmitted to humans via contaminated meat products. California Senate Bill 27 (SB27), which took effect on January 1, 2018, restricts the use of medically important antimicrobials in California food-animal production. Over time, SB27 could reduce the prevalence of an
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Exposure to organophosphate ester flame retardants and plasticizers during pregnancy and autism-related outcomes in the ECHO Cohort. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-11 Jennifer L Ames,Assiamira Ferrara,Juanran Feng,Stacey Alexeeff,Lyndsay A Avalos,Emily S Barrett,Theresa M Bastain,Deborah H Bennett,Jessie P Buckley,Courtney C Carignan,Patricia Cintora,Akhgar Ghassabian,Monique M Hedderson,Ixel Hernandez-Castro,Kurunthachalam Kannan,Margaret R Karagas,Catherine J Karr,Jordan R Kuiper,Donghai Liang,Kristen Lyall,Cindy T McEvoy,Rachel Morello-Frosch,Thomas G O'Connor
BACKGROUND Organophosphate ester flame retardants and plasticizers (OPEs) have myriad uses in industry and consumer products. Increasing human exposure to OPEs has raised concerns about their potential effects on child neurodevelopment during pregnancy. OBJECTIVE We investigated whether OPE urinary concentrations during pregnancy were associated with child autism-related outcomes. METHODS
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Linking "big" geospatial and health data: implications for research in environmental epidemiology. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-11 Andrea R Titus,Tarik Benmarhnia,Lorna E Thorpe
BACKGROUND Environmental epidemiology studies increasingly integrate "big" geospatial and health datasets to examine associations between environmental factors and health outcomes. Using such datasets - and linking between them - presents a number of complexities with regard to study design and analytic approaches. These complexities are often magnified with the integration of additional contextual
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Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-11 Akhgar Ghassabian,Aisha S Dickerson,Yuyan Wang,Joseph M Braun,Deborah H Bennett,Lisa A Croen,Kaja Z LeWinn,Heather H Burris,Rima Habre,Kristen Lyall,Jean A Frazier,Hannah C Glass,Stephen R Hooper,Robert M Joseph,Catherine J Karr,Rebecca J Schmidt,Chloe Friedman,Margaret R Karagas,Annemarie Stroustrup,Jennifer K Straughen,Anne L Dunlop,Jody M Ganiban,Leslie D Leve,Rosalind J Wright,Cindy T McEvoy,Alison
BACKGROUND The relationship between prenatal exposure to low-level air pollution and child autism spectrum disorder (ASD) is unclear. OBJECTIVE To examine associations of prenatal air pollution exposure with autism. METHODS We analyzed data from 8,035 mother-child pairs from 44 United States cohorts in the Environmental influences on Child Health Outcomes (ECHO) Cohort. Fine particulate matter
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Advancing extreme heat risk assessments to better capture individually-experienced temperatures: A new approach to describe individual and subgroup vulnerabilities. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-11 Carina J Gronlund,David M Hondula,Evan Mallen,Marie S O'Neill,Mayuri Rajput,E Scott Krayenhoff,Ashley Broadbent,Santiago C Grijalva,Larissa S Larsen,Sharon L Harlan,Brian Stone
BACKGROUND Extreme heat risk assessments often rely on epidemiologic studies that used the nearest available outdoor airport temperatures (OATs) rather than individually-experienced temperatures (IETs) and frequently lack key individual-level determinants of exposure, including occupation, housing, and air conditioning. This hampers efforts to characterize heat burden inequities and guide interventions
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Pesticide Exposure Estimation across Census Tracts in Washington State: Identifying Vulnerable Areas and Populations. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-10 Solmaz Amiri,Jeffrey M Bryant,Daniel H Farber,Ofer Amram,Jennifer C Sabel
INTRODUCTION Disparities in exposure to and harm associated with pesticides are established. However, high resolution spatial data on exposure to pesticides are lacking. PURPOSE To describe the development of a pesticide metric for Washington State and to evaluate the associations between pesticide exposure and sociodemographic characteristics of census tracts. METHODS We used the US cropland
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Prenatal exposure to ambient air pollution and fetal growth trajectories in Wuhan, China. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-10 Chen Hu,Hongxiu Liu,Yang Peng,Jie Hu,Wei Xia,Shunqing Xu,Yuanyuan Li
BACKGROUND While numerous studies have examined associations between prenatal air pollution exposure and fetal growth measures, investigations assessing longitudinal growth trajectories across multiple time points during mid-to-late pregnancy remain limited. OBJECTIVES The aim of this study is to explore the effects of prenatal exposure to air pollution during pregnancy on fetal growth trajectories
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The Association of Arsenic Exposure and Metabolism Biomarkers with Subclinical Measures of Liver Disease: a cross-sectional investigation in the Multi-Ethnic Study of Atherosclerosis. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-10 Hui-Chen Wu,Ronald A Glabonjat,Kathrin Schilling,William A Anderson,Siyue Gao,Arce Domingo Relloso,Nancy LoIacono,Monique Slowly,Anne E Nigra,Tiffany Sanchez,Marisa H Sobel,Marta Galvez-Fernandez,Matthew J Budoff,Mary V Gamble,Ana Navas-Acien,Mariana Lazo
BACKGROUND Long-term exposure to arsenic (As) can cause many health effects and As metabolism is key in the detoxification and elimination of As. We hypothesize that hepatic steatosis might affect As metabolism efficiency. We evaluated the association of As exposure and As metabolism biomarkers with hepatic steatosis. METHODS In this cross-sectional analysis, we analyzed data from 3,577 participants
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Associations of gestational and childhood urinary triclosan concentrations with atopic and allergic symptoms in Health Outcomes and Measures of the Environment (HOME) Study participants ages 1-12 years. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-09 Hannah E Laue,Elvira S Fleury,Medina S Jackson-Browne,Antonia M Calafat,Aimin Chen,Kimberly Yolton,Kim M Cecil,Nicholas C Newman,Jessie Buckley,Bruce P Lanphear,Joseph M Braun
BACKGROUND Triclosan, an antimicrobial chemical that was widely used in consumer products, may increase risk of allergic diseases in children, but prospective studies are needed to clarify the association. OBJECTIVES To elucidate the associations of time-varying urinary triclosan concentrations with eczema, allergic rhinitis, and wheeze. METHODS In the HOME Study, a prospective pregnancy and
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In utero per - and polyfluoroalkyl substances (PFAS) exposure and changes in infant T helper cell development among UPSIDE-ECHO cohort participants. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-09 Darline Castro Meléndez,Nathan Laniewski,Todd A Jusko,Xing Qiu,B Paige Lawrence,Zorimar Rivera-Núñez,Jessica Brunner,Meghan Best,Allison Macomber,Alena Leger,Kurunthachalam Kannan,Richard Kermit Miller,Emily S Barrett,Thomas G O'Connor,Kristin Scheible
BACKGROUND Environmental exposures to toxicants, such as per- and polyfluoroalkyl substances (PFAS), during gestation can disrupt immune development, causing long-term impacts on a child's ability to generate a well-regulated, protective immune response. T-cells coordinate with all immune cell types to orchestrate both cellular and antibody-mediated responses. While there is compelling evidence that
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Wildfire-season Fine Particulate Matter Exposure and Associations with Influenza and Influenza-like-illness Risk in the Western USA. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-09 Ava Orr,Nisha B Alden,Elizabeth Austin,Zeina Jaffar,Jonathon Knudson,Jon Graham,Christopher T Migliaccio,Curtis Noonan,Shawn Urbanski,Maximilian Wegener,Erin L Landguth
BACKGROUND Influenza remains a significant public health threat, with pandemic potential. Understanding environmental factors influencing virus spread and severity is critical, particularly as wildfires become more frequent and intense. While temperature and humidity's roles in virus seasonality and persistence are well understood, the impacts of air pollution-especially wildfire-specific particulate
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Source-specific air pollution and risk of chronic obstructive pulmonary disease: A pooled cohort study. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-09 Manuella Lech Cantuaria,Aslak Harbo Poulsen,Ole Raaschou-Nielsen,Étienne Audureau,Ralph Epaud,Sophie Lanone,Jørgen Brandt,Lisa Marie Frohn,Matthias Ketzel,Anja Olsen,Lau Caspar Thygesen,Mette Sørensen
BACKGROUND The evidence linking long-term exposure to air pollution and development of chronic obstructive pulmonary disease (COPD) is still controversial. Furthermore, most studies have investigated associations with particulate matter (PM) and nitrogen dioxide (NO2), disregarding their emission source and other relevant air pollutants, such as ultrafine particles (UFP) and elemental carbon (EC)
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Ambient temperature and injury-related emergency department visits in China and its Provinces: a large national case-crossover study. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-09 Guanhao He,Yuan Wang,Tao Liu,Xiao Deng,Jianxiong Hu,Yuliang Er,Pengpeng Ye,Qijiong Zhu,Ye Jin,Cuirong Ji,Ziqiang Lin,Fengrui Jing,Leilei Duan,Wenjun Ma
BACKGROUND Temperature-related risks on non-accidental morbidity or mortality have been well documented. However, limited studies have investigated the injury morbidity risk and burden attributed to ambient temperature. OBJECTIVE The current study aimed to assess the injury morbidity risk and burden attributed to ambient temperature in China. METHODS A time-stratified case-crossover study
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Pre-disease biomarkers of persistent organic pollutants (POPs) and amyotrophic lateral sclerosis (ALS) risk in Finland. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-09 Ian W Tang,Paul Knekt,Panu Rantakokko,Markku Heliövaara,Harri Rissanen,Päivi Ruokojärvi,Rajarshi Mukherjee,Marc G Weisskopf
BACKGROUND Persistent organic pollutants (POPs) are toxic chemicals that bioaccumulate and were used in pesticides and industrial products/processes. POP-exposed occupations and environmental exposure to POPs have been associated with amyotrophic lateral sclerosis (ALS), but no study has evaluated the association with ALS when measuring POPs in samples collected before ALS onset. OBJECTIVES This
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Dietary exposure to per- and polyfluoroalkyl substances and health risk assessment in 7-year-old children in Shandong, China. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-09 Yan Zhang,Qian Yao,Rong Shi,Jingguang Li,Angela Vinturache,Guanghe Wang,Xiaoning Lei,Yuxin Wang,Ying Tian,Yu Gao
BACKGROUND Dietary intake, especially foods of animal-origin, is an important source of per- and polyfluoroalkyl substances (PFAS) exposure to the general population. However, the distribution of legacy and emerging PFAS in different food categories is unclear, as well as their potential health risk for children. OBJECTIVES To investigate dietary sources of PFAS and evaluate the risk for 7-year-old
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Unlocking the Power of Data Harmonization in Environmental Health Sciences: A Comprehensive Exploration of Significance, Use Cases, and Recommendations for Standardization Efforts. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-06 Jeanette A Stingone,H C Bledsoe,Grace Cooney,Mireya Diaz-Insua,Elaine Faustman,Karamarie Fecho,Ramkiran Gouripeddi,Philip Holmes,David Kaeli,Oswaldo Lozoya,Anna Maria Masci,Hina Narayan,Charles Schmitt,Maria Shatz,Wren Tracy
BACKGROUND The field of environmental health sciences increasingly demands comprehensive and diverse datasets, particularly in response to emerging research areas such as climate change, mixtures, and exposomics. The data needed to address the complexity of environmental health research questions often extend beyond the boundaries of a single study or data resource. Traditional data management approaches
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Expanded Tox21 biological assay panel for the prediction of drug-induced liver injury and cardiotoxicity. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-06 Tuan Xu,Masato Ooka,Jinghua Zhao,Srilatha Sakamuru,Deborah K Ngan,Li Zhang,Shu Yang,Jameson Travers,Menghang Xia,Tongan Zhao,Carleen Klumpp-Thomas,Hu Zhu,Mathew D Hall,Stephen Ferguson,Natalie D Shaw,David M Reif,Anton Simeonov,Ruili Huang
BACKGROUND Toxicology in the 21st Century (Tox21) assay data provide a valuable resource for the prediction of in vivo toxicity using machine learning models. However, the performances of these models previously developed using the pre-existing Tox21 assay data were less than ideal, likely due to insufficient coverage of the biological response space by the assay targets. OBJECTIVES This study
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Trends in serum levels of emerging and legacy per- and polyfluoroalkyl substances from 2008 to 2018: a longitudinal study in China. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-06 Xu Cheng,Yu Wang,Jin Zhang,Hong Guo,Lin Liu,Lu Liu,Junya Gao,Meian He
BACKGROUND China is an important producer and consumer of per- and polyfluoroalkyl substances (PFAS), but there is limited understanding of longitudinal trends of PFAS in Chinese people. OBJECTIVES This study investigated decadal trends in PFAS and potential sources of exposure in the Dongfeng-Tongji cohort of Chinese people and explored potential misclassification bias. METHODS We repeatedly
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Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-06 Thanh T Hoang,Marta Cosin-Tomas,Yunsung Lee,Giulietta Monasso,Zongli Xu,Sebastian Shaobo Li,Xuehuo Zeng,Anne P Starling,Brigitte Reimann,Stefan Röder,Lea Zillich,Dereje D Jima,Chris H L Thio,Giancarlo Pesce,Elin T G Kersten,Charles E Breeze,Adam B Burkholder,Mikyeong Lee,James M Ward,Bios Consortium,Rossella Alfano,Michael Deuschle,Liesbeth Duijts,Akhgar Ghassabian,Laura-Concepció Gómez Herrera,Vincent
BACKGROUND Maternal sustained smoking during pregnancy is associated with thousands of differentially methylated CpGs in newborns, but impacts of other prenatal tobacco smoking exposures remain unclear. OBJECTIVE To identify differential DNA methylation in newborns from maternal sustained smoking and less studied prenatal smoking exposures (i.e., maternal exposure to secondhand smoke [SHS] exposure
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A new mouse model for ozone health effects research. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-05 Gregory J Smith,Robert M Immormino,Martin T Ferris,Sarah A Lester,Timothy P Moran,Jack R Harkema,Samir N P Kelada
BACKGROUND Exposure to the ambient air pollutant ozone (O3) is associated with adverse respiratory health outcomes. Rodent models have been used to identify mechanisms of response to O3 but their utility has been questioned owing to species differences in physiologic response, most notably exposure-induced hypothermia, which renders rodents relatively resistant to O3 compared to humans. OBJECTIVES
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Exposures to drinking water contaminants in community water systems and risk of ovarian cancer in the California Teachers Study cohort. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-05 Maya Spaur,Lauren M Hurwitz,Danielle N Medgyesi,Alexander P Keil,Laura E Beane Freeman,Jared A Fisher,Jessica M Madrigal,Samantha Ammons,Emma S Spielfogel,Komal Bangia,Paul S Albert,Tiffany R Sanchez,James V Lacey,Rena R Jones,Mary H Ward
BACKGROUND Several drinking water contaminants are known or suspected carcinogens; however, there are only a few investigations of drinking water exposures and ovarian cancer. We evaluated associations between regulated contaminants in community water systems (CWS) and ovarian cancer risk in the California Teachers Study, a prospective cohort of female California educators. METHODS Participants
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The Association of Blood Lead with Cardiovascular Disease Incidence and Mortality: Findings from the Strong Heart Study Cohort. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-05 Wil Lieberman-Cribbin,Anne E Nigra,Allison Kupsco,Arce Domingo-Relloso,Kathrin Schilling,Ying Zhang,Amanda M Fretts,Shelley Cole,Jason G Umans,Jeffery M Jarrett,Michael Lewin,Patricia Ruiz,Zheng Li,Ana Navas-Acien
BACKGROUND Evidence on lead and the burden of cardiovascular disease (CVD) derived from National Health and Nutrition Examination Survey (NHANES) data, a general sample of the U.S. population, lacks sufficient representation of American Indians. Moreover, there is limited prospective evidence on lead and incident CVD outcomes. OBJECTIVES We evaluated if blood lead levels were associated with CVD
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Beyond the Surface: Mapping DDE's Metabolic Footprint on Adolescent Obesity. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-03 Zhenjiang Li,Shudi Pan,Brittney O Baumert,Jiawen Carmen Chen,Jesse A Goodrich,Hongxu Wang,Sarah Rock,Justin Ryder,Damaskini Valvi,Todd Jenkins,Stephanie Sisley,Xiangping Lin,Scott M Bartell,Thomas H Inge,Stavra Xanthakos,Brooklynn McNeil,Anna R Robuck,Catherine E Mullins,Sandrah P Eckel,Rob S McConnell,Michele A La Merrill,Douglas I Walker,David V Conti,Lida Chatzi
BACKGROUND Bariatric surgery is an intervention for severe obesity, leading to significant weight loss and metabolic improvements. However, the release of lipophilic chemicals accumulated in adipose tissue during weight loss presents a unique clinical challenge and research opportunity. Dichlorodiphenyldichloroethylene (DDE) is a persistent organic pollutant increasingly recognized as obesogen, while
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Time-varying exposure to element mixtures and children's cognition at 5 years of age: findings from the New Hampshire Birth Cohort Study. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-03 Leyre Notario Barandiaran,Julie A Bauer,Hannah E Laue,Antonio J Signes-Pastor,Brian P Jackson,Janet L Peacock,Juliette Madan,David C Bellinger,Susan Korrick,Margaret R Karagas
BACKGROUND Exposure to metals and metalloids (hereafter referred to as 'metals') during gestation and early childhood may affect children's neurodevelopment. However, few studies have simultaneously evaluated the impact of exposure to both essential and non-essential metals across specific windows of exposure on children's neurodevelopmental outcomes. OBJECTIVE To investigate whether levels of
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Effects of extreme heat exposure on heatstroke and liver injury in mice: The role of PPARα. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-30 Guoqing Zhang,Lisha Zhao,Jiahui Wang,Kunyi Wang,Xiuyu Ji,Renjie Hu,Tong Hou,Lu Zhang,Ran Li,Qinghua Sun,Kezhong Zhang,Cuiqing Liu
BACKGROUND Liver injury is a frequent complication of heatstroke and constitutes a direct cause of death. However, only a few studies examined the mechanism underlying heatstroke-induced liver injury. OBJECTIVE We aimed to evaluate the role of peroxisome proliferator-activated receptor α (PPARα) in heatstroke-induced liver injury and explore the potential mechanisms. METHODS Male C57BL/6N
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Thirdhand Smoke Exposes Children Living with Smokers and Nonsmokers to Tobacco Smoke Toxicants: Racial, Income, and Housing Disparities in Hand Nicotine and Saliva Cotinine Levels. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-29 E Melinda Mahabee-Gittens,Ashley L Merianos,Nicolas Lopez-Galvez,Penelope J E Quintana,Eunha Hoh,Nathan G Dodder,Lara Stone,Chase A Wullenweber,Georg E Matt
BACKGROUND Children may be involuntarily exposed to chemical residue from thirdhand tobacco smoke (THS) in environments where tobacco has previously been used. Factors contributing to this exposure among children of nonsmokers with no known secondhand smoke (SHS) exposure are currently unknown. OBJECTIVE To understand the contribution of THS residue to the overall tobacco smoke exposure (TSE)
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An integrated machine learning framework to understand zoonotic spillover emergence across anthropogenically modified landscapes. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-21 Yinsheng Zhang,Jinchen Wang,Luqi Wang,Linxuan Miao,Yifan Sun,Xin Yang,Ruying Fang,Yiyang Guo,Sophie Vanwambeke,Sen Li
BACKGROUND Anthropogenic land modification influences human-livestock-wildlife interactions and zoonotic spillover emergence. However, the extent of this impact remains unclear and could be better understood through the collaborative use of advanced predictive and explanatory analytical tools, alongside, an up-to-date dataset on zoonotic spillover events. OBJECTIVE The main objective is to develop
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Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-21 Cody Z Watling,Jessica L Petrick,Barry I Graubard,Xuehong Zhang,Matthew J Barnett,Julie E Buring,Yu Chen,A Heather Eliassen,Michael Gaziano,Jae H Kang,Jill Koshiol,Wen-Yi Huang,I-Min Lee,Steven C Moore,Lorelei A Mucci,Marian L Neuhouser,Christina C Newton,Julie R Palmer,Lynn Rosenberg,Howard D Sesso,Martha Shrubsole,Lesley Tinker,Matthew Triplette,Caroline Y Um,Kala Visvanathan,Jean Wactawski-Wende
BACKGROUND Per- and polyfluoroalkyl substances (PFAS) have been associated with numerous deleterious health outcomes including liver damage. However, whether exposure to PFAS is associated with liver cancer risk remains unclear. METHODS We conducted a matched nested case-control study among 12 prospective cohort studies located in the United States. Pre-diagnostic PFAS, namely perfluorooctanesulfonate
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Effect of household air pollution on the gut microbiome and virome of adult women living in Uganda. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-21 Ching-Ying Huang,Edwin Nuwagira,Michael Tisza,Minsik Kim,Mellon Tayebwa,Jacob Vieira,Nicholas Lam,Eli Wallach,Matthew Wiens,Alexander C Tsai,Linda Valeri,Jose Vallarino,Joseph G Allen,Peggy S Lai
BACKGROUND Emerging observational studies suggest air pollution can influence the gut microbiome. However, this association is often highly confounded by factors such as diet and poverty. The gut virome may influence respiratory health independent of the gut microbiome. We recently demonstrated in a randomized waitlist-controlled trial (ClinicalTrials.gov NCT03351504) that a clean lighting intervention
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Comparison of Temperature-Mortality Associations Across the Middle East Using Different Exposure Estimation Approaches. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-21 Yazan Alwadi,Barrak Alahmad,Marc G Weisskopf,Petros Koutrakis
BACKGROUND Traditional temperature-health studies have predominantly relied on temperature measurements from stations or modelled spatial averages from gridded temperature datasets. It has been suggested that population-weighted spatial averages would perform better in remote regions with large temperature and population variability. This would be particularly true in regions other than North America
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Statistical Methods for Chemical Mixtures: A Roadmap for Practitioners Using Simulation Studies and a Sample Data Analysis in the PROTECT Cohort. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-19 Wei Hao,Amber L Cathey,Max M Aung,Jonathan Boss,John D Meeker,Bhramar Mukherjee
BACKGROUND Quantitative characterization of the health impacts associated with exposure to chemical mixtures has received considerable attention in current environmental and epidemiological studies. With many existing statistical methods and emerging approaches, it is important for practitioners to understand which method is best suited for their inferential goals. OBJECTIVE The goal of this paper
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External Validation of STopTox - Novel Alternative Method (NAM) for Acute Systemic and Topical Toxicity. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-20 Ricardo Scheufen Tieghi,Cleber C Melo-Filho,Holli-Joi Martin,José Teófilo Moreira-Filho,Tripp LaPratt,Dave Allen,Judy Strickland,Alexander Tropsha,Nicole Kleinstreuer,Eugene N Muratov
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A prospective exposome-based gene-environment interaction study on the effects of prenatal environmental exposure on fetal growth in the Shanghai Birth Cohort. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-20 Wen Jiang,Yun Huang,Hong Jin,Yuexin Gan,Qingli Zhang,Xiaoqing He,Ying Tian,Jun Zhang, The Shanghai Birth Cohort
BACKGROUND Both environmental exposure and type 2 diabetes (T2D) genetic susceptibility affect fetal growth. However, most previous studies used single exposure rather than an exposome strategy to explore the association between environmental factors and fetal growth, and the interactions of environmental exposures with maternal and fetal genes were often overlooked. OBJECTIVES To explore the
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Preterm and early-term delivery after heat waves in eight US states: A case-crossover study using the High-resolution Urban Meteorology for Impacts Dataset (HUMID). Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-20 Amy Fitch,Mengjiao Huang,Matthew Strickland,Andrew Newman,Christina Kalb,Joshua L Warren,Xiaping Zheng,Howard Chang,Lyndsey Darrow
BACKGROUND Heat wave frequency and intensity is increasing and this trend is more pronounced in urban areas. Heat waves may be acutely associated with early birth. OBJECTIVES To examine the acute relationship between heat waves and preterm (<37 weeks) and early-term (37-38 weeks) birth in eight states: California, Florida, Georgia, Kansas, Nevada, New Jersey, North Carolina, and Oregon. METHODS
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Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-16 Yi-Fen Chiang,Yang-Ching Chen,Ko-Chieh Huang,Mohamed Ali,Shih-Min Hsia
BACKGROUND The impact of non-nutritive sweeteners on male reproductive health, particularly at the cellular level, remains insufficiently explored. Sucralose's high stability and resistance to degradation during wastewater treatment raises concerns about its long-term environmental and health impacts. Whether sucralose consumption correlates with reduced reproductive hormone levels and testicular
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Development of the Food Systems-Related Greenhouse Gas Emissions Factor Database Using the Korea National Health and Nutrition Examination Survey (2016-2018). Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-18 Jee Yeon Hong,Mi Kyung Kim
BACKGROUND The increase in the frequency and scale of climate-related disasters is closely linked to greenhouse gas emissions (GHGEs) from food systems. Due to a lack of a comprehensive emission database that covers entire food systems, data on per capita dietary GHGEs are limited. OBJECTIVE We created the Food Systems-related GHGE Factor Database (FS-GHGEF-D) to cover an entire food system and
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Household fuel use and kidney disease-related mortality: the Golestan Cohort Study. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-15 Michele Sassano,Monireh Sadat Seyyedsalehi,Sudabeh Alatab,Hossein Poustchi,Mahdi Sheikh,Arash Etemadi,Reza Malekzadeh,Paolo Boffetta
BACKGROUND A large proportion of global population uses solid fuels for household purposes, and limited evidence from previous studies suggests that it might be associated with reduced renal function. OBJECTIVES To investigate the association between household use of different types of fuels and kidney disease-related mortality. METHODS We analyzed data from the Golestan Cohort Study, a population-based
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Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-05-15 Chen Tang,Ying Zhang,Fucong Zhang,Yiwen Sun,Yue Zhu,Fanzheng Xue,Zhenhong Wang,You Wu,Jinpeng Ruan,Yiming Yue,Chunyan Yang,Wei Ge,Chengyong He,Zhenghong Zuo
BACKGROUND Ovarian folliculogenesis is crucial for female reproduction. This can be disrupted by various factors, including pollutants with aryl hydrocarbon receptor (AHR) agonistic activity, but the underlying mechanisms remain unclear. OBJECTIVES Using the herbicide neburon, a moderate AHR agonist among current pesticides, we investigated its effects on ovarian folliculogenesis in zebrafish
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Integrating Transcriptomic and Targeted New Approach Methodologies into a Tiered Framework for Chemical Bioactivity Screening. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-13 Jesse D Rogers,Joseph L Bundy,Joshua A Harrill,Richard J Judson,Katie Paul-Friedman,Logan J Everett
BACKGROUND With thousands of chemicals in commerce and the environment, rapid identification of potential hazards is a critical need. Combining broad molecular profiling with targeted in vitro assays, such as high-throughput transcriptomics (HTTr) and receptor screening assays, could improve identification of chemicals that perturb key molecular targets associated with adverse outcomes. OBJECTIVES
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Projections of Heat-Related Mortality in Chinese Cities: The Roles of Climate Change, Urbanization, Socioeconomic Adaptation, and Landscape-Level Strategies. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-13 Xue Liu,Ming Hao,Yuyu Zhou,Yue Zhang,Ziheng Xu,Xiaojuan Liu,Yukun Gao,Rui Li,Han Zhang,Xia Li,Xiaoping Liu,Yuanzhi Yao
BACKGROUND Physiological heat strain induced by extreme temperatures in cities has led to significant heat-related deaths. Although socioeconomic adaptation is suggested to mitigate this issue, its effectiveness is limited. Conversely, there is a lack of comprehensive evaluation on the effectiveness of landscape-level strategies for mitigating heat-related deaths. OBJECTIVES We developed a comprehensive
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Effects of Bisphenol A and Retinoic Acid Exposure on Neuron and Brain Formation: A Study in Human Induced Pluripotent Stem Cells and Zebrafish Embryos. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-13 Tomomi Nishie,Tomoki Taya,Shunichi Omori,Kenya Ueno,Yoshinori Okamoto,Shogo Higaki,Marina Oka,Yachiyo Mitsuishi,Taiga Tanaka,Mana Nakamoto,Hideaki Kawahara,Natsuki Teraguchi,Tomoyuki Kotaka,Misaki Sawabe,Miu Takahashi,Shoko Kitaike,Minori Wada,Keiko Iida,Akihiro Yamashita,Hideto Jinno,Atsuhiko Ichimura,Ikuo Tooyama,Noriyoshi Sakai,Masahiko Hibi,Akira Hirasawa,Tatsuyuki Takada
BACKGROUND Developing human fetuses may be exposed to the chemical compound bisphenol A (BPA), and retinoic acid (RA) has been detected at low levels in water sources. RA signaling regulates key developmental genes and is essential for organ development, including the brain. We previously reported that RA/BPA coexposure of mouse embryonic stem cells potentiates RA signaling, which warrants further
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Effects of Cooking with Liquefied Petroleum Gas or Biomass Fuels on Neurodevelopmental Outcomes in Preschool-Age Children Living in Puno, Peru. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-05 Carolyn J Reuland,Laura Nicolaou,Maureen M Black,Mingling Yang,Ryan McCord,Milagros Alvarado,Fiorela Arana,Paola S Sanchez,Kendra N Williams,Shakir Hossen,Marilú Chiang,Stella M Hartinger,William Checkley
BACKGROUND Burning biomass fuels for cooking is a widespread environmental exposure that may adversely affect child health. We conducted an 18-month randomized field trial comparing a liquefied petroleum gas (LPG) stove, continuous fuel delivery, and behavioral messaging intervention starting in pregnancy through infancy with usual cooking practices using biomass fuels in Puno, Peru. A total of 800
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Health Trade-Offs of Boiling Drinking Water with Solid Fuels: A Modeling Study. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-23 Emily Floess,Ayse Ercumen,Angela R Harris,Andrew P Grieshop
BACKGROUND Billions of the world's poorest households are faced with the lack of access to both safe drinking water and clean cooking. One solution to microbiologically contaminated water is boiling, often promoted without acknowledging the additional risks incurred from indoor air degradation from using solid fuels. OBJECTIVES This modeling study explores the trade-off of increased air pollution
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Estimation of Dermal Exposure to Volatile Organic Compounds (VOCs) from Feminine Hygiene Products: Integrating Measurement Data and Physiologically Based Toxicokinetic (PBTK) Model. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-20 Nan Lin,Zengwei Li,Ning Ding,Sung Kyun Park,Stuart Batterman,Wei Du,Jiayin Dai,Ying Zhu
BACKGROUND An increasing number of studies have reported noteworthy health risks associated with dermal exposure to volatile organic compounds (VOCs) from feminine hygiene products (FHPs). OBJECTIVES This study sought to address the gap in understanding the absorption, distribution, metabolism, and excretion dynamics of dermal exposure to VOCs from FHPs and to identify chemicals and products that
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A Machine Learning-Based Clustering Analysis to Explore Bisphenol A and Phthalate Exposure from Medical Devices in Infants with Congenital Heart Defects. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-18 Wei-Chun Chou,J William Gaynor,Eric M Graham,Brenna Klepczynski,Tia Walker,Eric S Coker,Richard F Ittenbach,Zhoumeng Lin
BACKGROUND Plastic-containing medical devices are commonly used in critical care units and other patient care settings. Patients are often exposed to xenobiotic agents that are leached out from plastic-containing medical devices, including bisphenol A (BPA) and phthalates. Given the potential health implications, there is an urgent need for a comprehensive understanding of this exposure. OBJECTIVES
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Association between Perfluorooctanoic Acid-Related Poor Embryo Quality and Metabolite Alterations in Human Follicular Fluid during IVF: A Cohort Study. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-18 Junting Xu,Qiaoling Wang,Xianting Jiao,Pengcheng Kong,Siyu Chen,Wanli Yang,Wenqiang Liu,Kunming Li,Xiaoming Teng,Yi Guo
BACKGROUND Perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been shown to disrupt normal follicular development and ovulation. However, it is unknown which specific PFAS in follicular fluid negatively impact oocyte development and embryo quality or whether any of the metabolites present in the follicular fluid contribute to these adverse effects. OBJECTIVES We conducted a cross-sectional
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Comparing the Role of Relative and Absolute Humidity in Heat-Related Mortality: A Case Time-Series Study in South Korea. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-16 Jieun Min,Whanhee Lee,Jieun Oh,Cinoo Kang,Eunhee Ha
BACKGROUND Epidemiology studies have reported inconsistent associations of humidity with heat-related health outcomes, despite strong plausibility of such physiological associations. In this regard, there has been a heated debate on which humidity metric to use in epidemiological research. OBJECTIVES This study aimed to compare the role of two common humidity metrics, relative and absolute humidity
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Effect Modification of Serum Omega-3 Fatty Acids on the Associations between Urinary Phthalate Biomarkers Mixture and Pregnancy Outcomes among Women Seeking Fertility Care. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-06 Xilin Shen,Maximilien Génard-Walton,Paige L Williams,Jennifer B Ford,Irene Souter,Yazeed Allan,Antonia M Calafat,Dan Zhang,Jorge E Chavarro,Russ Hauser,Lidia Mínguez-Alarcón,
BACKGROUND Phthalate exposures are ubiquitous and have been associated with pregnancy complications. Interaction between serum long-chain n-3 polyunsaturated fatty acids (n3PUFA) and phthalate biomarkers is biologically plausible because both can bind to human peroxisome proliferator-activated receptors (PPARs), which are involved in placenta development. However, evidence of this interaction in humans
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Air Pollution and Autism Spectrum Disorder: Unveiling Multipollutant Risks and Sociodemographic Influences in California. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-12 Karl O'Sharkey,Sanjali Mitra,Ting Chow,Laura Thompson,Jason Su,Myles Cockburn,Beate Ritz
BACKGROUND Autism spectrum disorder (ASD) is a neurodevelopmental condition with increasing prevalence worldwide. Air pollution may be a major contributor to the rise in ASD cases. This study investigated how the risk of ASD associated with prenatal and early postnatal exposure to specific air pollutants is modified by key sociodemographic factors, exploring vulnerable exposure periods. METHODS
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A State of the Science Review of Wildfire-Specific Fine Particulate Matter Data Sources, Methods, and Models. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-11 Ava Orr,Claire E Adam,Jon Graham,Zachary A Holden,Lu Hu,Zeina Jaffar,Cindy Leary,Christopher T Migliaccio,Katrina Mullan,Curtis Noonan,Erin O Semmens,Shawn Urbanski,Ethan Walker,Erin L Landguth
BACKGROUND Despite progress in reducing industrial air pollution, rising wildfire frequency and intensity, driven in part by climate change, pose significant health risks. Accurate estimates of wildfire-generated fine particulate matter with an aerodynamic diameter <2.5μm (PM2.5) are needed for advancing health research, policymaking, and environmental protection. OBJECTIVE This review evaluates
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Perinatal Exposure to Lead or Diethylhexyl Phthalate in Mice: Sex-Specific Effects on Cardiac DNA Methylation and Gene Expression across Time. Environ. Health Perspect. (IF 9.8) Pub Date : 2025-06-16 Kai Wang,Minghua Li,Maureen A Sartor,Justin A Colacino,Dana C Dolinoy,Laurie K Svoboda
BACKGROUND Global and site-specific changes in DNA methylation and gene expression are associated with cardiovascular development, aging, and disease, but how the transcriptome and epigenome of the heart change across the life course in males vs. females and how chemical exposures early in life influence this programming have not yet been investigated. OBJECTIVES We used an established mouse model