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The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-18 Chang-Yu Song, Chih-Ying Wu, Chih-Yang Lin, Chun-Hao Tsai, Hsien-Te Chen, Yi-Chin Fong, Li-Chai Chen, Chih-Hsin Tang
Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and is associated with lung metastases. Extracellular vesicles called exosomes are primarily used as mediators of intercellular signal transmission to control tumor metastasis. Visfatin is an adipokine reported to enhance tumor metastasis, but its relationship with exosome generation in chondrosarcoma motility
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Down‐regulating lncRNA KCNQ1OT1 relieves type II alveolar epithelial cell apoptosis during one‐lung ventilation via modulating miR‐129‐5p/HMGB1 axis induced pulmonary endothelial glycocalyx Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Zhenghuan Song, Zhongqiu Wang, Jiaqin Cai, Yihu Zhou, Yueyi Jiang, Jing Tan, Lianbin Gu
ObjectiveEndothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed after one‐lung ventilation (OLV)‐induced lung injury. Long noncoding RNAs (lncRNAs) are critically involved in various lung injuries. This study aimed to investigate the role and regulatory mechanism of KCNQ1 overlapping transcript 1 (KCNQ1OT1) in OLV‐induced lung injury and LPS‐induced type II alveolar epithelial
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Exploring the tumor microenvironment: Chemokine‐related genes and immunotherapy/chemotherapy response in clear‐cell renal cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Yuhao Meng, Chen Zhang, Tongfei Fu, Jiaheng He, Junsong Wu, Yongli Zhan
BackgroundThe treatment of clear‐cell renal cell carcinoma (ccRCC) remains challenge. Chemokines laid impact on the proliferation and metastasis of cancer cells. The objective was to identify the chemokine‐related genes and construct a prognostic model for ccRCC.MethodsBulk transcriptomic data (n = 531), single‐cell RNA sequencing (scRNA‐seq) dataset GSE159115, and other validation cohorts were acquired
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LncRNA MRAK052509 competitively adsorbs miR‐204‐3p to regulate silica dust‐induced EMT process Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Liu Xuan, Jiao Zi‐ming, Tian Xue‐yan, Hu Wen‐xuan, Wang Fa‐xuan
Silicosis is a systemic disease caused by long‐term inhalation of free SiO2 and retention in the lungs. At present, it is still the most important occupational health hazard disease in the world. Existing studies have shown that non‐coding RNA can also participate in complex fibrosis regulatory networks. However, its role in regulating silicotic fibrosis is still unclear. In this study, we constructed
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Protein phosphatase 2A modulation and connection with miRNAs and natural products Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Ya‐Ting Chuang, Ching‐Yu Yen, Jen‐Yang Tang, Fang‐Rong Chang, Yi‐Hong Tsai, Kuo‐Chuan Wu, Tsu‐Ming Chien, Hsueh‐Wei Chang
Protein phosphatase 2A (PP2A), a heterotrimeric holoenzyme (scaffolding, catalytic, and regulatory subunits), regulates dephosphorylation for more than half of serine/threonine phosphosites and exhibits diverse cellular functions. Although several studies on natural products and miRNAs have emphasized their impacts on PP2A regulation, their connections lack systemic organization. Moreover, only part
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RSPO2‐associated mitochondrial metabolism defines molecular subtypes with distinct clinical and immune features in esophageal cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Quanzhou Peng, Tianfeng Cao, Xue Yang, Zhujia Ye, Jun Wang, Shang Chen, Yanqi Yu, Yingdian Yu, Wenyuan Xue, Zhiwei Chen, Jianbing Fan
BackgroundEsophageal cancer is a highly aggressive malignancy with limited treatment options and poor prognosis. The identification of novel molecular subtypes and therapeutic targets is crucial for improving clinical outcomes.MethodIn this study, we investigated the role of R‐spondin 2 (RSPO2) in esophageal cancer and its association with mitochondrial metabolism. Using bioinformatics analysis of
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Nickel induces epithelial‐mesenchymal transition in pulmonary fibrosis in mice via activation of the oxidative stress‐mediated TGF‐β1/Smad signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Shanchuan Cao, Heng Yin, Xinglai Li, Xin Zeng, Jingbo Liu
Nickel (Ni) is recognized as a carcinogenic metal, and its widespread use has led to severe environmental and health problems. Although the lung is among the main organs affected by Ni, the precise mechanisms behind this effect remain poorly understood. This study aimed to elucidate the physiological mechanisms underlying Ni‐induced pulmonary fibrosis (PF), using various techniques including histopathological
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TFEB ameliorates DEHP‐induced neurotoxicity by activating GAL3/TRIM16 axis dependent lysophagy and alleviating lysosomal dysfunction Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Hengrui Xing, Panpan Xu, Yue Ma, Tingting Li, Yue Zhang, Xueman Ding, Li Liu, Mulatibieke Keerman, Qiang Niu
Di‐(2‐ethylhexyl) phthalate (DEHP) is a commonly used plasticizer with known neurotoxic effects. However, the specific mechanism underlying this neurotoxicity remains unclear. This study aimed to investigate the role of lysosomal function and lysophagy in DEHP‐induced neurotoxicity, with a particular focus on the regulatory role of Transcription factor EB (TFEB). To achieve this, we utilized in vitro
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Unraveling the role of low‐density lipoprotein‐related genes in lung adenocarcinoma: Insights into tumor microenvironment and clinical prognosis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Pengpeng Zhang, Xinyi Wu, Dingli Wang, Mengzhe Zhang, Bin Zhang, Zhenfa Zhang
BackgroundThe hypothesized link between low‐density lipoprotein (LDL) and oncogenesis has garnered significant interest, yet its explicit impact on lung adenocarcinoma (LUAD) remains to be elucidated. This investigation aims to demystify the function of LDL‐related genes (LRGs) within LUAD, endeavoring to shed light on the complex interplay between LDL and carcinogenesis.MethodsLeveraging single‐cell
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Exploring the impact of ITGB2 on glioma progression and treatment: Insights from non‐apoptotic cell death and immunotherapy Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Junhong Zhuang, Changfeng Miao, Chao Liu, Biying Zeng, Linwang Hu, Jun Peng, Ying Xia, Zigui Chen
In the realm of glioma treatment, our groundbreaking research has uncovered the pivotal role of Integrin Beta 2 (ITGB2) in non‐apoptotic cell death and its profound implications for immunotherapy efficacy. Gliomas, known for their aggressive and infiltrative nature, demand innovative therapeutic strategies for improved patient outcomes. Our study bridges a critical gap by examining the interplay between
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The intracellular concentrations of fluoroquinolones determined the antibiotic resistance response of Escherichia coli J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Xuejing Ma, Han Yeong Kaw, Jing Yu, Qi Yang, Lizhong Zhu, Wei Wang
The extensive consumption of antibiotics has been reported to significantly promote the generation of antibiotic resistance (ABR), however, a quantitative causal relationship between antibiotic exposure and ABR response is absent. This study aimed to pinpoint the accurate regulatory concentration of fluoroquinolones (FQs) and to understand the biochemical mechanism of the mutual action between FQ exposure
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Vital role of CYP450 in the biodegradation of antidiabetic drugs in the aerobic activated sludge system and the mechanisms J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Ligui Wu, Hao Luo, Jingcheng Xu, Ling Yu, Jiangtao Xiong, Yizhi Liu, Xiangfeng Huang, Xiaoming Zou
The extensive use of antidiabetic drugs (ADDs) and their detection in high concentrations in the environment have been extensively documented. However, the mechanism of ADDs dissipation in aquatic environments is still not well understood. This study thoroughly investigates the dissipation behavior of ADDs and the underlying mechanisms in the aerobic activated sludge system. The results indicate that
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Improving the Removal Efficiency of Oxygenated Volatile Organic Compounds by Defective UiO-66 Regulated with Water J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Jiajun Yu, Xiao Wang, Guanhong Lu, Haijiao Xie, Xiaofeng Xie, Jing Sun
The purification of oxygenated volatile organic compounds VOCs (OVOCs), important precursors of ozone and particulate matters, has triggered intensive research interests. UiO-66 with high photocatalytic activity have shown great potential. However, the lack of active sites severely limited the trapping and degradation of OVOCs. Herein, reo-UiO-66 with increased specific surface area, hierarchical porous
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Neurotoxicities induced by micro/nanoplastics: A review focusing on the risks of neurological diseases J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Shuang Liu, Yinling He, Jia Yin, Qingqing Zhu, Chunyang Liao, Guibin Jiang
Pollution of micro/nano-plastics (MPs/NPs) is ubiquitously prevalent in the environment, leading to an unavoidable exposure of the human body. Despite the protection of the blood-brain barrier, MPs/NPs can be transferred and accumulated in the brain, which subsequently exert negative effects on the brain. Nevertheless, the potential neurodevelopmental and/or neurodegenerative risks of MPs/NPs remain
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Effects of biodegradable microplastics on arsenic migration and transformation in paddy soils: a comparative analysis with conventional microplastics J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Qiuying An, Zhuo Zhen, Nijing Zhong, Donghua Qiu, Yunhe Xie, Changzhou Yan
The combined pollution of microplastics (MPs) and arsenic (As) in paddy soils has attracted more attention worldwide. However, there are few comparative studies on the effects of biodegradable and conventional MPs on As migration and transformation. Therefore, conventional (polystyrene, polyethylene, polyvinyl chloride) and biodegradable (polybutadiene styrene, polylactic acid, polybutylene adipate
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Deciphering silver nanoparticles perturbation effects and risks for soil enzymes worldwide: Insights from machine learning and soil property integration J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Zhenjun Zhang, Jiajiang Lin, Gary Owens, Zuliang Chen
Globally extensive research into how silver nanoparticles (AgNPs) affect enzyme activity in soils with differing properties has been limited by cost-prohibitive sampling. In this study, customized machine learning (ML) was used to extract data patterns from complex research, with a hit rate of Random Forest > Multiple Imputation by Chained Equations > Decision Tree > K-Nearest Neighbors. Results showed
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Effect of hydrodynamic and ecosystem conditions on persistent organic pollutant temporal-spatial variations in the Yellow Sea J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Aobo WANG, Xinyu GUO, Xiaokun DING, Jie SHI, Jianhui TANG
Coastal seas are important pools of persistent organic pollutants (POPs) discharged from land. Considering the complex conditions in coastal seas and various biochemical features of POPs, special temporal-spatial variations in POPs have been reported. To understand these variations, we developed a three-dimensional hydrodynamic–ecosystem–POP coupled model and applied it to the Yellow Sea. We selected
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Effect of water-soluble polymers on the transport of functional group-modified polystyrene nanoplastics in goethite-coated saturated porous media J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Guangcai Zhang, Binying Wang, Nan Jiang, Kejing Pang, Wenbing Wu, Xianqiang Yin
The research on the impact of water-soluble polymers (WSPs) on the migration and fate of plastic particles is extremely limited. This article explores the effects of polyacrylic acid (PAA, a common WSP) and physicochemical factors on the transport of polystyrene nanoparticles (PSNPs-NH/COOH) with different functional groups in QS (quartz sand) and FOS (goethite-modified quartz sand, simulates mineral
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Chemically sprayed pristine and Cd 2+ incorporated Co2SnO4 thin films for low ppm level enhanced chemi - resistive behaviour towards dimethylamine detection at room temperature J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Nallakumar Santhosh, Muthurakku Usha Rani
The surge in hazardous volatile organic liquid emissions driven by the rapid growth of the manufacturing industry has compelled a rising demand for gas sensors, which exhibit remarkable sensitivity, selectivity, and room temperature operation. Ternary metal oxide spinel has indeed garnered significant attention in chemi-resistive gas sensors due to their large reactive surface area, physicochemical
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Unveiling the multilevel impact of four water-soluble polymers on Daphnia magna: from proteome to behaviour (a case study) J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Lara Nigro, Stefano Magni, Marco Aldo Ortenzi, Stefano Gazzotti, Camilla Della Torre, Silvia Giorgia Signorini, Riccardo Sbarberi, Andrea Binelli
The ubiquitous presence of water-soluble polymers (WSPs) in freshwater environments raises concerns regarding potential threats to aquatic organisms. This study investigated, for the first time, the effects of widely used WSPs -polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), polyacrylic acid (PAA), and polyethylene glycol (PEG)- using a multi-level approach in the freshwater biological model
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New insights into changes in phosphorus profile at sediment-water interface by microplastics: Role of benthic bioturbation J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-15 Xiaojun Song, Jiannan Ding, Yunbo Zhang, Mingda Zhu, Yi Peng, Zhenyu Wang, Gang Pan, Hua Zou
Microplastics (MPs) have attracted increasing attention due to their ubiquitous occurrence in freshwater sediments and the detrimental effects on benthic invertebrates. However, a clear understanding of their downstream impacts on ecosystem services is still lacking. This study examines the effects of bio-based polylactic acid (PLA), fuel-based polyethylene terephthalate (PET), and biofilm-covered
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Natural organic small molecules promote the aging of plastic wastes and refractory carbon decomposition in water J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-14 Xiangang Hu, Shuting Wang, Ruihong Feng, Kai Hu
Microplastics and nanoplastics are ubiquitous in rivers and undergo environmental aging. However, the molecular mechanisms of plastic aging and the in-depth effects of aging on ecological functions remain unclear in waters. The synergies of microplastics and nanoplastics (polystyrene as an example) with natural organic small molecules (e.g., natural hyaluronic acid and vitamin C related to biological
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Degradation of Veterinary Antibiotics by the Ozonation Process: Product Identification and Ecotoxicity Assessment J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-14 Ewa Adamek, Wojciech Baran
The purpose of the study was to evaluate the effects of using of ozonation to remove antibiotics used, among others, in veterinary medicine, from the aqueous environment. The effect of this process on the degradation, mineralisation and ecotoxicity of aqueous solutions of ampicillin, doxycycline, tylosin, and sulfathiazole was investigated. Microbiological MARA® bioassay and two methods were used for
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Ratiometric fluoroprobe based on Eu-MOF@Tb3+ for detecting tetracycline hydrochloride in freshwater fish and its application in rapid visual detection J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-14 Longtian Chen, Zhongjie Li, Yuemao Dou, Huili Wang, Chunyang Chen, Xuedong Wang
Tetracycline hydrochloride (TCH), a prevalent antibiotic in aquaculture for treating bacterial infections, poses challenges for on-site detection. This study employed the reversed-phase microemulsion method to synthesize a uniform nano metal-organic framework (MOF) material, europium-benzene-p-dicarboxylic acid (Eu-BDC), doped with Tb to form a dual-emission fluorescence probe. By leveraging the combined
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Integrated analysis of gut microbiota and metabolomic profiling in colorectal cancer metastasis Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-14 Yang Xia, Ling Duan, Xin‐lian Zhang, Yu‐juan Niu, Xiaoling Ling
Colorectal cancer (CRC) is characterized by its heterogeneity and complex metastatic mechanisms, presenting significant challenges in treatment and prognosis. This study aimed to unravel the intricate interplay between the gut microbiota and metabolic alterations associated with CRC metastasis. By employing high‐throughput sequencing and advanced metabolomic techniques, we identified distinct patterns
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Refining molecular subtypes and risk stratification of ovarian cancer through multi‐omics consensus portfolio and machine learning Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-14 Jing Zhang, Shanshan He, Hongjun Ying
Ovarian cancer (OC), known for its pronounced heterogeneity, has long evaded a unified classification system despite extensive research efforts. This study integrated five distinct multi‐omics datasets from eight multicentric cohorts, applying a combination of ten clustering algorithms and ninety‐nine machine learning models. This methodology has enabled us to refine the molecular subtyping of OC,
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Ammonia oxidation by in-situ chloride electrolysis in etching wastewater of semiconductor manufacturing using RuSnOx/Ti electrode: effect of plating mode and metal ratio J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Seto Sugianto Prabowo Rahardjo, Yu-Jen Shih, Chen-Shiuan Fan
The indirect chloride-mediated ammonia oxidation encounters challenges in maintaining the effectiveness of metal oxide anodes when treating wastewaters with complex compositions. This study aims to develop a highly stable anode with RuO-SnO coatings for treating an etching effluent from semiconductor manufacturing, which majorly contains NH and organic compounds. The RuSnO/Ti electrode was synthesized
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Spotlight on the vertical migration of aged microplastics in coastal waters J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Xiaohan Yang, Guohe Huang, Zhikun Chen, Qi Feng, Chunjiang An, Linxiang Lyu, Huifang Bi, Siyuan Zhou
Coastal waters are complex and dynamic areas with unique environmental attributes that complicate the vertical migration of microplastics (MPs). The MPs that enter coastal waters from diverse sources, including terrestrial, riverine, oceanic, and shoreline inputs undergo various aging pathways. In this study, the variations in the physiochemical characteristics of MPs undergoing various aging pathways
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Arsenic Field Test Kits based on Solid-Phase Fluorescence Filter Effect Induced by Silver Nanoparticle Formation J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Wenhui Yang, Liqing Ye, Yuke Wu, Xi Wang, Simin Ye, Yurong Deng, Ke Huang, Hong Luo, Jinyi Zhang, Chengbin Zheng
Millions of people worldwide are affected by naturally occurring arsenic in groundwater. The development of a low-cost, highly sensitive, portable assay for rapid field detection of arsenic in water is important to identify areas for safe wells and to help prioritize testing. Herein, a novel paper-based fluorescence assay was developed for the on-site analysis of arsenic, which was constructed by the
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Biotransformation of HBCDs by the microbial communities enriched from mangrove sediments J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Fei Yu, Bing Zhang, Yongjin Liu, Wenqi Luo, Haonan Chen, Jun’na Gao, Xueying Ye, Jin Li, Qingyi Xie, Tao Peng, Hui Wang, Tongwang Huang, Zhong Hu
1,2,5,6,9,10-Hexabromocyclododecanes (HBCDs) are a sort of persistent organic pollutants (POPs). This research investigated 12 microbial communities enriched from sediments of four mangroves in China to transform HBCDs. Six microbial communities gained high transformation rates (27.5-97.7%) after 12 generations of serial transfer. Bacteria were the main contributors to transform HBCDs rather than fungi
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Unveiling complete natural reductive dechlorination mechanisms of chlorinated ethenes in groundwater: Insights from functional gene analysis J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Zhuanxia Zhang, Mukhtiar Ali, Zhiwen Tang, Qi Sun, Qing Wang, Xin Liu, Lipu Yin, Song Yan, Minmin Xu, Frederic Coulon, Xin Song
Monitored natural attenuation (MNA) of chlorinated ethenes (CEs) has proven to be a cost-effective and environment-friendly approach for groundwater remediation. In this study, the complete dechlorination of CEs with formation of ethene under natural conditions, were observed at two CE-contaminated sites, including a pesticide manufacturing facility (PMF) and a fluorochemical plant (FCP), particularly
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Effects of dissolved organic matter and halogen ions on phototransformation of pharmaceuticals and personal care products in aquatic environments J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Fangyuan Cheng, Tingting Zhang, Hao Yang, Yue Liu, Jiao Qu, Ya-nan Zhang, Willie J.G.M. Peijnenburg
Photochemical reactions contribute to the attenuation and transformation of pharmaceuticals and personal care products (PPCPs) in surface natural waters. Nevertheless, effects of DOM and halogen ions on phototransformation of PPCPs remain elusive. This work selected disparate PPCPs as target pollutants to investigate their aquatic phototransformation processes. Results show that PPCPs containing multiple
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Processes and mechanisms in remediation of aqueous chromium contamination by sulfidated nano-scale zerovalent iron (S-nZVI): Experimental and computational investigations J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Yuanyuan Wang, Yuesuo Yang, Jinyu Shi, Wengang An, Tao Lyu, Ping Zhang
Sulfidated nano-scale zerovalent iron (S-nZVI) has emerged as an advanced functional nanomaterial for efficiently remediating Cr(VI) contamination in aqueous environments. However, there is an insufficient understanding of its coherent process, removal pathway, and hydrochemical reactive mechanisms, presenting potential challenges for its future environmental applications. To address this gap, this
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In vitro cell-transforming potential of secondary polyethylene terephthalate and polylactic acid nanoplastics J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Josefa Domenech, Aliro Villacorta, Juan Francisco Ferrer, Raquel Llorens, Ricard Marcos, Alba Hernández, Julia Catalán
Continuous exposure to plastic pollutants may have serious consequences on human health. However, most toxicity assessments focus on non-environmentally relevant particles and rarely investigate long-term effects such as cancer induction. The present study assessed the carcinogenic potential of two secondary nanoplastics: polyethylene terephthalate (PET) particles generated from plastic bottles, and
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Ferrate(VI)/percarbonate for the oxidation of micropollutants: interactive activation and release of low-concentration hydrogen peroxide for efficient electron utilization J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Zhongjuan Wang, Xi Yang, Qi Du, Tong Liu, Xin Dai, Ye Du, Heng Zhang, Peng Zhou, Zhaokun Xiong, Bo Lai
A novel "ferrate/percarbonate (Fe(VI)/SPC) co-oxidation process" was used to treat ciprofloxacin (CIP) and various micropollutants (MPs), which owned better performance than mixture of Fe(VI), NaCO and HO. The mechanism investigation found that the low-concentration HO (1-2µM) released by SPC can promote the high-valent iron intermediates (Fe(IV)/Fe(V)) of Fe(VI) to the MP oxidation, and Fe(VI) products
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Absorption and translocation of selected pharmaceuticals in Pistia stratiotes: spatial distribution analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Jiaxi Wang, Yiwen Zhu, Beibei Ye, Junling Dun, Xia Yu, Qian Sui
Phytoremediation can eliminate pharmaceuticals from aquatic environments through absorption; however, understanding of absorption and transport processes in plants remains limited. In this study, a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging (MALDI-MSI) method was developed to explore the absorption and translocation mechanisms of seven common pharmaceuticals
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Enhanced Extraction of Heavy Metals from Gypsum-based Hazardous Waste by Nanoscale Sulfuric Acid Film at Ambient Conditions J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Wenjing Li, Chunli Wang, Guiquan Che, Min Su, Zhihao Zhang, Weizhen Liu, Zhang Lin, Jing Zhang
Low-cost, low-energy extraction of heavy metal(loid)s (HMs) from hazardous gypsum cake is the goal of the metallurgical industry to mitigate environmental risks and carbon emissions. However, current extracting routes of hydrometallurgy often suffer from great energy inputs and substantial chemical inputs. Here, we report a novel solid-like approach with low energy consumption and chemical input to
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Exploring the neurotoxicity of chiral dinotefuran towards nicotinic acetylcholine receptors: Enantioselective insights into species selectivity J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Zhi-Cong He, Tao Zhang, Wei Peng, Qiong Mei, Qi-Zhao Wang, Fei Ding
Dinotefuran is a chiral neonicotinoid that is widely distributed in environmental matrices, but its health risks to different organisms are poorly understood. This study investigated the neurotoxic responses of honeybee/cotton aphid nicotinic acetylcholine receptors (nAChRs) to chiral dinotefuran at the enantiomeric scale and demonstrated the microscopic mechanism of species selectivity in nAChR-mediated
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ROS-Dependent Degeneration of Human Neurons Induced by Environmentally Relevant Levels of Micro- and Nanoplastics of Diverse Shapes and Forms J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Kinga Vojnits, Andrés de León, Harneet Rathore, Sophia Liao, Michael Zhao, Julien Gibon, Sepideh Pakpour
Our study explores the pressing issue of micro- and nanoplastics (MNPs) inhalation and their subsequent penetration into the brain, highlighting a significant environmental health concern. We demonstrate that MNPs can indeed penetrate murine brain, warranting further investigation into their neurotoxic effects in humans. We then proceed to test the impact of MNPs at environmentally relevant concentrations
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Association between air pollution and male sexual function: a nationwide observational study in China J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Ziyuan Shen, Feng Zhang, Zihan Guo, Rui Qu, Yiqiu Wei, Jingxuan Wang, Weiqian Zhang, Xing Xing, Yan Zhang, Jue Liu, Dongdong Tang
This study aimed to explore the associations between air pollution and male sexual function. A total of 5047 male subjects in China were included in this study. The average air pollution exposure (PM, PM, SO, CO, NO, and O) for the preceding 1, 3, 6, and 12 months before the participants' response was assessed. Male sexual function was evaluated using the International Index of Erectile Function-5
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Prenatal Exposure to Poly/Perfluoroalkyl Substances and Risk for Congenital Heart Disease in Offspring J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Sainan Li, Chengrong Wang, Chen Yang, Yongyan Chen, Qianhui Cheng, Jufen Liu, Yali Zhang, Lei Jin, Zhiwen Li, Aiguo Ren, Linlin Wang
Congenital heart disease (CHD) is the most prevalent congenital malformation worldwide, and the association between per- and polyfluoroalkyl substances (PFASs) exposure and CHD in population has only received limited study. Therefore, we conducted a multicenter case-control study to explore the associations between prenatal exposure to individual PFASs, and also a PFAS mixture, and CHD risk, including
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Heat and mass transfer based on the low-temperature thermal treatment of hydrocarbons-impacted soil: a numerical simulation and sandbox validation J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Wei Fang, Lian Zhou, Yan Li, Haixiao Li, Hua Zhong, Yuanyuan Zha
Thermal treatment can be an effective method for soil remediation, and numerical models play a crucial role in elucidating the underlying processes that affect efficacy. In this study, experiments were conducted to examine the low-temperature thermal treatment for removing n-hexane and n-octane from soil. The results showed that the removal of two alkanes followed the pseudo-first-order kinetics. Additionally
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Maternal prednisone exposure during pregnancy elevates susceptibility to osteoporosis in female offspring: the role of mitophagy/FNDC5 alteration in skeletal muscle J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Zun-Yu Du, Hua-Long Zhu, Wei Chang, Yu-Feng Zhang, Qing Ling, Kai-Wen Wang, Jin Zhang, Quan-Bing Zhang, Xiu-Li Kan, Qu-Nan Wang, Hua Wang, Yun Zhou
Maternal exposure to glucocorticoids has been associated with adverse outcomes in offspring. However, the consequences and mechanisms of gestational exposure to prednisone on susceptibility to osteoporosis in the offspring remain unclear. Here, we found that gestational prednisone exposure enhanced susceptibility to osteoporosis in adult mouse offspring. In a further exploration of myogenic mechanisms
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One-step online analysis of antibiotics in highly saline seawater by nano-based slug-flow microextraction J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Meng Zhang, Ruonan Shang, Ziying Hong, Hong Zhang, Kai Yu, Guangfeng Kan, Huixia Xiong, Daqian Song, Yanxiao Jiang, Jie Jiang
The transition to mass spectrometry (MS) in the analysis of antibiotics in the marine environment is highly desirable, particularly in the enhancement of sensitivity for high-salinity (3.5 wt%) seawater samples. However, the persistence of complex operational procedures poses substantial challenges to this transition. In this study, a rapid method for the online analysis of antibiotics in seawater
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Occurrence, bioaccumulation and trophodynamics of organophosphate esters in the marine biota web of Laizhou Bay, Bohai Sea J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Maoshan Lian, Jing Wang, Zongxing Wang, Chunye Lin, Xiang Gu, Mengchang He, Xitao Liu, Wei Ouyang
The trophodynamic of organophosphate esters (OPEs) has not been known well despite their widespread occurrence in the aquatic environments. In this study, ten species of crustacean, seven species of mollusk, and 22 species of fish were collected in the Laizhou Bay (LZB) to examine the occurrence, bioaccumulation, and trophic transfer, and health risk of eight traditional OPEs and three emerging oligomeric
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Microplastics enhance the invasion of exotic submerged macrophytes by mediating plant functional traits, sediment properties, and microbial communities J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Xiaowei Li, Hongjie Qin, Na Tang, Xiaolu Li, Wei Xing
Plant invasions and microplastics (MPs) have significantly altered the structure and function of aquatic habitats worldwide, resulting in severe damage to aquatic ecosystem health. However, the effects of MPs on plant invasion and the underlying mechanisms remain largely unknown. In this study, we conducted mesocosm experiments over a 90-day period to assess the effects of polystyrene microplastics
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An evaluation of microplastic contamination in the marine waters and species in the coastal region of the South Yellow Sea, China J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Xiaoping Sun, Ruiping Yang, Jing Ji, Zebin Zhu, Jason C. White, Yu Shen
Microplastics (MPs) contamination of marine environments poses a significant ecological risk, although impacts on species’ realized niche spaces remain unclear. The current study investigates MPs distribution across pelagic habitats, benthic sediments, and key biota in the South Yellow Sea, China. Samples were collected via trawling across estuarine transects, and tissues were digested to extract MPs
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Change characteristics, bacteria host, and spread risks of bioaerosol ARGs/MGEs from different stages in sewage and sludge treatment process J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-13 Yanjie Wang, Kai Yang, Lin Li, Liying Yang, Song Zhang, Fangfang Yu, Linlin Hua
The spread of antibiotic resistance genes (ARGs) in the atmospheric environment has seriously threatened human health. Wastewater treatment plants (WWTPs) are an important source of aerosol ARGs. A large WWTP, including sewage treatment process (SWP) and sludge treatment process (SDP), was selected in North China for sampling in this study. The content of ARGs, mobile genetic elements (MGEs), and bacterial
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MiR‐2110 induced by chemically synthesized cinobufagin functions as a tumor‐metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Shiyi Fang, Lanzhu Peng, Mengmin Zhang, Rentao Hou, Xing Deng, Xiaoning Li, Jianyang Xin, Lingrong Peng, Zhihua Liu, Yiyi Liu, Yingying Xie, Beixian Zhou, Weiyi Fang, Zhen Liu, Chao Cheng
Tumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma (NPC). MiR‐2110 was cloned and identified in Epstein–Barr virus (EBV)‐positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR‐2110 on NPC metastasis and its related molecular basis. In addition, we also explored whether miR‐2110 can be regulated by cinobufotalin (CB) and
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Lysine specific demethylase 1 inhibits sodium arsenite activation of HSCs by regulating SESN2/AMPK/ULK1 signaling pathway activity Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Yingwan Zhang, Tian Tian, Cai Liang, Junli Wang, Jiayuan Zhang, Shanshan Tian, Rujia Xie, Ting Yang, Bing Han
Lysine specific demethylase 1 (LSD1) is a histone demethylase that specifically catalyzes the demethylation of histone H3K4 (H3K4me1/2) and regulates gene expression. In addition, it can mediate the process of autophagy through its demethylase activity. Sestrin2 (SESN2) is a stress‐induced protein and a positive regulator of autophagy. In NaAsO2‐induced mouse fibrotic livers and activated hepatic stellate
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Exploration of immune cell heterogeneity by single‐cell RNA sequencing and identification of secretory leukocyte protease inhibitor as an oncogene in pancreatic cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Bolun Ai, Yicheng Liang, Tao Yan, Yangyang Lei
Clinical outcomes remain unsatisfactory in patients with pancreatic cancer (PAC). In this study, through single‐cell sequencing, we identified eight cell subpopulations in the tumor microenvironment (TME). Redimensional clustering of epithelial cells, myeloid cells, and cancer‐associated fibroblasts (CAFs) revealed heterogeneity in the TME of PAC. Intercellular communication analysis showed strong
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Prediction of potential targets and toxicological insights of Astragalus in liver cancer based on network pharmacology: Integrating systems biology, drug interaction networks, and toxicological perspectives Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-13 Minjun Zou, Zhiye Zheng, Zhikai Xiahou, Jianwei Cao
This study investigates Astragalus's efficacy as a novel therapeutic option for primary liver cancer (PLC), capitalizing on its anti‐inflammatory and antiviral effects. We utilized network pharmacology to unveil Astragalus's potential targets against PLC, revealing significant gene expression alterations in treated samples—20 genes were up‐regulated, and 20 were down‐regulated compared to controls
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Atmospheric microplastic deposition in association with GDP and population growth: insights from megacities in northern China J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Pengju Liu, Longyi Shao, Yaxing Zhang, Ville Silvonen, Henry Oswin, Yaxin Cao, Ziyu Guo, Xuying Ma, Lidia Morawska
Microplastic (MP) pollution is evolving into one of the most pressing environmental concerns worldwide. This study assessed the impact of economic activities on atmospheric MP pollution across 17 megacities in northern China, analyzing the correlation between the deposition flux of atmospheric MPs and variables such as city population, gross domestic product (GDP), and industrial structure. The results
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Exploring recyclable Alginate-Enhanced GCN-LDO Sponge for U(VI) and Cd(II) Ion Removal: Insights from Batch and Column Studies J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Zahid Husain Momin, Lakshmi Prasanna Lingamdinne, Rakesh Kulkarni, Chandrika Ashwinikumar Pal, Yu-Lim Choi Yoon-Young Chang, Janardhan Reddy Koduru
Developing effective water treatment materials, particularly through proven adsorption methods, is crucial for removing heavy metal contaminants. This study synthesizes a cost-effective three-dimensional material encapsulating graphitic carbon nitride-layered double oxide (GCN-LDO) in sodium alginate (SA) through the freeze-drying method. The material is applied to remove uranium (U(VI)) and cadmium
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Selective leaching of indium from spent LCD screens by siderophore desferrioxamine E J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Kun Zheng, Marc F. Benedetti, Rohan Jain, Bradley M. Guy, Katrin Pollmann, Eric D. van Hullebusch
Given the criticality of indium (In) in high-tech applications, spent LCD screens can represent a viable secondary In resource. In this work, an innovative and alternative technology to selectively leach In from spent LCD screens using a microbial chelating agent, desferrioxamine E (DFOE), was developed. Indium was concentrated from spent LCD screens by implementing an adapted pre-treatment procedure
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Determination of Asbestos Cement Rooftop Surface Composition using Regression Analysis and Hyper-Spectral Reflectance Data in the Visible and Near-Infrared Ranges J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Mira Sabat, Noura Fares, Georges Mitri, Adib Kfoury
The effects of asbestos on human health have spurred numerous studies examining its risks in urban environments. Recent works have shifted towards less-invasive techniques for remote detection and classification of asbestos-cement. In this context, this study combines visible (VIS) and near-infrared (NIR) reflectance data collected with reference signals from the USGS spectral library, utilizing optimized
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Innovative non-targeted screening approach using High-resolution mass spectrometry for the screening of organic chemicals and identification of specific tracers of soil and dust exposure in children J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Olutobi Daniel Ogunbiyi, Luciana Teresa Dias Cappelini, Mymuna Monem, Emily Mejias, Florence George, Piero Gardinali, Daniel M. Bagner, Natalia Quinete
Environmental contamination through direct contact, ingestion and inhalation are common routes of children’s exposure to chemicals, in which through indoor and outdoor activities associated with common hand-to-mouth, touching objects, and behavioral tendencies, children can be susceptible and vulnerable to organic contaminants in the environment. The objectives of this study were the screening and
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Hydrogeochemical characteristics, stable isotopes, positive matrix factorization, source apportionment, and health risk of high fluoride groundwater in semiarid region J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Abdur Rashid, Muhammad Ayub, Xubo Gao, Seema Anjum Khattak, Liaqat Ali, Chengcheng Li, Ajaz Ahmad, Sardar Khan, Jörg Rinklebe, Parvaiz Ahmad
Chronic exposure to high fluoride (F) levels in groundwater causes community fluorosis and non-carcinogenic health concerns in local people. This study described occurrence, dental fluorosis, and origin of high F-groundwater using δH and δO isotopes at semiarid Gilgit, Pakistan. Therefore, groundwater (n = 85) was collected and analyzed for F concentrations using ion-chromatography. The lowest F concentration
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High performance self-assembled sulfidized nanoscale zero-valent iron for the immobilization of cadmium in contaminated sediments: Optimization, microbial response, and mechanisms J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Yiqun Xu, Hongdou Liu, Siqi Wen, Jiaming Guo, Xiaoyu Shi, Qi He, Weilong Lin, Yang Gao, Rongzhong Wang, Wenjing Xue
Sulfidized nanoscale zero-valent iron (S-nZVI) showed excellent removal capacity for cadmium (Cd) in aqueous phase. However, the remediation effects of S-nZVI on Cd-contaminated sediment and its interactions with microorganisms in relation to Cd fate remain unclear. The complexity of the external environment posed a challenge for Cd remediation. This study synthesized S-nZVI with different S and Fe
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Metal-organic framework-based ratiometric point-of-care testing for quantitative visual detection of nitrite J. Hazard. Mater. (IF 13.6) Pub Date : 2024-03-12 Maosheng Liang, Yifan Gao, Xiaoling Sun, Rong-Mei Kong, Lian Xia, Fengli Qu
Nitrite (NO) is categorized as a carcinogenic substance and is subjected to severe limitations in water and food. To safeguard the public’s health, developing fast and convenient methods for determination of NO is of significance. Point-of-care testing (POCT) affords demotic measurement of NO and shows huge potential in future technology beyond those possible with traditional methods. Here, a novel