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Opportunities to Interrupt Transmission of Enteropathogens of Poultry Origin in Maputo, Mozambique: A Transmission Model Analysis. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-11-01 Kayoko Shioda,Andrew F Brouwer,Frederica Lamar,Hermógenes N Mucache,Karen Levy,Matthew C Freeman
BACKGROUND The burden of diarrheal diseases remains high among children in low-income countries. Enteropathogens are challenging to control because they are transmitted via multiple pathways. Chickens are an important animal protein source, but live chickens and their products are often highly contaminated with enteropathogens. OBJECTIVES We conducted this study to a) understand the contribution of
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Global Air Pollutant Phenanthrene and Arrhythmic Outcomes in a Mouse Model. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-11-01 Sana Yaar,Tatiana S Filatova,Ellie England,Shiva N Kompella,Jules C Hancox,David A Bechtold,Luigi Venetucci,Denis V Abramochkin,Holly A Shiels
BACKGROUND The three-ringed polycyclic aromatic hydrocarbon (PAH) phenanthrene (Phe) has been implicated in the cardiotoxicity of petroleum-based pollution in aquatic systems, where it disrupts the contractile and electrical function of the fish heart. Phe is also found adsorbed to particulate matter and in the gas phase of air pollution, but to date, no studies have investigated the impact of Phe
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Xenobiotic Exposure and Migraine-Associated Signaling: A Multimethod Experimental Study Exploring Cellular Assays in Combination with Ex Vivo and In Vivo Mouse Models. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-11-01 Rikke H Rasmussen,Sarah L Christensen,Kirstine Calloe,Brian Skriver Nielsen,Anders Rehfeld,Thomas E Taylor-Clark,Kristian A Haanes,Olivier Taboureau,Karine Audouze,Dan A Klaerke,Jes Olesen,David M Kristensen
BACKGROUND Mechanisms for how environmental chemicals might influence pain has received little attention. Epidemiological studies suggest that environmental factors such as pollutants might play a role in migraine prevalence. Potential targets for pollutants are the transient receptor potential (TRP) channels ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1), which on activation release pain-inducing neuropeptide
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Invited Perspective: The Silent Threat-Air Pollution's Link to Arrhythmias. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-11-01 Flavia Bonalumi,Michele Miragoli
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Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-30 Michelle C Turner,Vincent Cogliano,Kathryn Guyton,Federica Madia,Kurt Straif,Elizabeth M Ward,Mary K Schubauer-Berigan
BACKGROUND The International Agency for Research on Cancer (IARC) Monographs program assembles expert working groups who publish a critical review and evaluation of data on agents of interest. These comprehensive reviews provide a unique opportunity to identify research needs to address classification uncertainties. A multidisciplinary expert review and workshop held in 2009 identified research gaps
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Invited Perspective: How Far Have We Come? Revisiting a 2009 Report on Occupational Cancer Research Recommendations. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-30 Mark P Purdue,Mary H Ward
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Per- and Polyfluoroalkyl Substances and Anti-Müllerian Hormone Concentrations in Two Preconception Cohort Studies. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-26 Lauren A Wise,Tanran R Wang,Ellen M Mikkelsen,Amelia K Wesselink,Antonia M Calafat,Ganesa Wegienka,Ruth J Geller,Chad M Coleman,Mary D Willis,Erica E Marsh,Samantha Schildroth,Julianne C Botelho,Geralyn Messerlian-Lambert,Elizabeth E Hatch
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Fine Particulate Matter Metal Composition, Oxidative Potential, and Adverse Birth Outcomes in Los Angeles. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-25 Qi Meng,Jonathan Liu,Jiaqi Shen,Irish Del Rosario,Pascale S J Lakey,Manabu Shiraiwa,Jason Su,Scott Weichenthal,Yifang Zhu,Farzan Oroumiyeh,Suzanne E Paulson,Michael Jerrett,Beate Ritz
BACKGROUND Although many studies have linked prenatal exposure to PM2.5 to adverse birth outcomes, little is known about the effects of exposure to specific constituents of PM2.5 or mechanisms that contribute to these outcomes. OBJECTIVES Our objective was to investigate effects of oxidative potential and PM2.5 metal components from non-exhaust traffic emissions, such as brake and tire wear, on the
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Ambient Air Pollution Exposure and Cerebral White Matter Hyperintensities in Older Adults: A Cross-Sectional Analysis in the Three-City Montpellier Study. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-25 Jeanne Duchesne,Isabelle Carrière,Sylvaine Artero,Adam M Brickman,Jerome Maller,Chantal Meslin,Jie Chen,Danielle Vienneau,Kees de Hoogh,Bénédicte Jacquemin,Claudine Berr,Marion Mortamais
BACKGROUND Growing epidemiological evidence suggests an adverse relationship between exposure to air pollutants and cognitive health, and this could be related to the effect of air pollution on vascular health. OBJECTIVE We aim to evaluate the association between air pollution exposure and a magnetic resonance imaging (MRI) marker of cerebral vascular burden, white matter hyperintensities (WMH). METHODS
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Stirring Up Trouble? Forest Disturbance and the Spread of a Fungal Disease. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-25 Olayinka Osuolale
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Seminar: Extracellular Vesicles as Mediators of Environmental Stress in Human Disease. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-20 Vrinda Kalia,Andrea A Baccarelli,Christine Happel,Jonathan A Hollander,Anne Marie Jukic,Kimberly A McAllister,Ramkumar Menon,Bruce A Merrick,Aleksander Milosavljevic,Lingamanaidu V Ravichandran,Matthew E Roth,Anita Subramanian,Frederick L Tyson,Leroy Worth,Daniel T Shaughnessy
BACKGROUND Extracellular vesicles (EVs), membrane-bound particles containing a variety of RNA types, DNA, proteins, and other macromolecules, are now appreciated as an important means of communication between cells and tissues, both in normal cellular physiology and as a potential indicator of cellular stress, environmental exposures, and early disease pathogenesis. Extracellular signaling through
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Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-19 Aizhen Wang,Yanjian Wan,Gaga Mahai,Xi Qian,Yuanyuan Li,Shunqing Xu,Wei Xia
BACKGROUND Widespread insecticide exposure might be a risk factor for neurodevelopment of our children, but few studies examined the mixture effect of maternal coexposure to organophosphate insecticides (OPPs), pyrethroids (PYRs), and neonicotinoid insecticides (NNIs) during pregnancy on child neurodevelopment, and critical windows of exposure are unknown. OBJECTIVES We aimed to evaluate the association
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Association of Redlining and Natural Environment with Depressive Symptoms in Women in the Sister Study. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-18 Wei-Lun Tsai,Maliha S Nash,Daniel J Rosenbaum,Steven E Prince,Aimee A D'Aloisio,Megan H Mehaffey,Dale P Sandler,Timothy J Buckley,Anne C Neale
BACKGROUND Improving mental health is recognized as an important factor for achieving global development goals. Despite strong evidence that neighborhood greenery promotes better mental health, there are environmental justice concerns over the distribution of neighborhood greenery. Underlying these concerns are present-day consequences of historical discriminatory financial investment practices, such
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Invited Perspective: Forging a Way Forward Amid the Enduring Impacts of Redlining. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-18 Miatta A Buxton,Marie S O'Neill
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Prenatal Exposure to Multiple Endocrine-Disrupting Chemicals and Childhood BMI Trajectories in the INMA Cohort Study. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-18 Parisa Montazeri,Nuria Güil-Oumrait,Sandra Marquez,Lourdes Cirugeda,Andrea Beneito,Mònica Guxens,Aitana Lertxundi,Maria-Jose Lopez-Espinosa,Loreto Santa-Marina,Jordi Sunyer,Maribel Casas,Martine Vrijheid
BACKGROUND Prenatal exposure to endocrine-disrupting chemicals (EDCs) may disrupt normal fetal and postnatal growth. Studies have mainly focused on individual aspects of growth at specific time points using single chemical exposure models. However, humans are exposed to multiple EDCs simultaneously, and growth is a dynamic process. OBJECTIVE The objective of this study was to evaluate the associations
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Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-18 Matthieu Mancini,Denis Hémon,Perrine de Crouy-Chanel,Laurence Guldner,Laure Faure,Jacqueline Clavel,Stéphanie Goujon
BACKGROUND Pesticide exposures are suspected of being a risk factor for several childhood cancers, particularly acute leukemia (AL). Most of the evidence is based on self-reported parental domestic use of pesticides, but some studies have also addressed associations with agricultural use of pesticides near the place of residence. OBJECTIVES The objective of the study was to evaluate the risk of AL
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Beyond Wind and Flood: Review of Cyclone Research Spotlights Trauma Outcomes. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-17 Charles Schmidt
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Fanning the Flames: Low-Level Air Pollution and Risk of Surgery or Mortality for Persons with IBD. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-16 Wendee Nicole
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Nested Case-Control Studies Investigating Serum Perfluorooctanoate and Perfluorooctane Sulfonate Levels and Pancreatic Ductal Adenocarcinoma in Two Cohorts. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-16 Ting Zhang,Sheng Fu,Kai Yu,Demetrius Albanes,Steven C Moore,Mark P Purdue,Rachael Z Stolzenberg-Solomon
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Journal of Health and Pollution: Fostering Equity in Access to Environmental Health Research Evidence. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-12 Kalpana Balakrishnan,Joel D Kaufman
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Urinary Glyphosate, 2,4-D and DEET Biomarkers in Relation to Neurobehavioral Performance in Ecuadorian Adolescents in the ESPINA Cohort. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-11 Briana N C Chronister,Kun Yang,Audrey R Yang,Tuo Lin,Xin M Tu,Dolores Lopez-Paredes,Harvey Checkoway,Jose Suarez-Torres,Sheila Gahagan,Danilo Martinez,Dana Barr,Raeanne C Moore,Jose R Suarez-Lopez
BACKGROUND Herbicides are the most used class of pesticides worldwide, and insect repellents are widely used globally. Yet, there is a dearth of studies characterizing the associations between these chemical groups and human neurobehavior. Experimental studies suggest that glyphosate and 2,4-dichlorophenoxyacetic acid (2,4-D) herbicides can affect neurobehavior and the cholinergic and glutamatergic
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Assessing Metabolic Differences Associated with Exposure to Polybrominated Biphenyl and Polychlorinated Biphenyls in the Michigan PBB Registry. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-10 Susan S Hoffman,Donghai Liang,Robert B Hood,Youran Tan,Metrecia L Terrell,M Elizabeth Marder,Hillary Barton,Melanie A Pearson,Douglas I Walker,Dana Boyd Barr,Dean P Jones,Michele Marcus
BACKGROUND Polybrominated biphenyls (PBB) and polychlorinated biphenyls (PCB) are persistent organic pollutants with potential endocrine-disrupting effects linked to adverse health outcomes. OBJECTIVES In this study, we utilize high-resolution metabolomics (HRM) to identify internal exposure and biological responses underlying PCB and multigenerational PBB exposure for participants enrolled in the
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Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-05 Xiaoqi Peng,Yunfeng Mao,Yingju Tai,Bin Luo,Qian Dai,Xiyang Wang,Hao Wang,Yue Liang,Ruirui Guan,Chunhua Liu,Yiping Guo,Lin Chen,Zhi Zhang,Haitao Wang
BACKGROUND Commonly encountered nontraumatic, moderate noise is increasingly implicated in anxiety; however, the neural substrates underlying this process remain unclear. OBJECTIVES We investigated the neural circuit mechanism through which chronic exposure to moderate-level noise causes anxiety-like behaviors. METHODS Mice were exposed to chronic, moderate white noise [85 decibel (dB) sound pressure
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Exposure to Particulate Matter Air Pollution and Age of Menarche in a Nationwide Cohort of U.S. Girls. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-04 Robert B Hood,Jaime E Hart,Francine Laden,Bernard Rosner,Jorge E Chavarro,Audrey J Gaskins
BACKGROUND It remains unclear whether in utero and childhood exposure to air pollution affects pubertal development, particularly age of menarche in girls. OBJECTIVE The aim of this study was to determine whether residential ambient particulate matter (PM) exposure in utero and during childhood is associated with age of menarche. METHODS We studied 5,201 girls in the Growing Up Today Study 2 (2004-present)
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Ambient PM2.5 Exposure and Bone Homeostasis: Analysis of UK Biobank Data and Experimental Studies in Mice and in Vitro. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-04 Qinwen Ge,Sijia Yang,Yu Qian,Jiali Chen,Wenhua Yuan,Sanduo Li,Pinger Wang,Ran Li,Lu Zhang,Guobo Chen,Haidong Kan,Sanjay Rajagopalan,Qinghua Sun,Hou-Feng Zheng,Hongting Jin,Cuiqing Liu
BACKGROUND Previous evidence has identified exposure to fine ambient particulate matter (PM2.5) as a leading risk factor for adverse health outcomes. However, to date, only a few studies have examined the potential association between long-term exposure to PM2.5 and bone homeostasis. OBJECTIVE We sought to examine the relationship between long-term PM2.5 exposure and bone health and explore its potential
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Long-Term Exposure to Walkable Residential Neighborhoods and Risk of Obesity-Related Cancer in the New York University Women's Health Study (NYUWHS). Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-04 Sandra India-Aldana,Andrew G Rundle,James W Quinn,Tess V Clendenen,Yelena Afanasyeva,Karen L Koenig,Mengling Liu,Kathryn M Neckerman,Lorna E Thorpe,Anne Zeleniuch-Jacquotte,Yu Chen
BACKGROUND Living in neighborhoods with higher levels of walkability has been associated with a reduced risk of obesity and higher levels of physical activity. Obesity has been linked to increased risk of 13 cancers in women. However, long-term prospective studies of neighborhood walkability and risk for obesity-related cancer are scarce. OBJECTIVES We evaluated the association between long-term average
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Invited Perspective: Studying Walkability and Cancer Incidence-A Step in the Right Direction. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-10-04 Charlotte Roscoe,Cindy R Hu,Paul J Villeneuve
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Disparities in Toxic Chemical Exposures and Associated Neurodevelopmental Outcomes: A Scoping Review and Systematic Evidence Map of the Epidemiological Literature. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-27 Devon C Payne-Sturges,Tanya Khemet Taiwo,Kristie Ellickson,Haley Mullen,Nedelina Tchangalova,Laura Anderko,Aimin Chen,Maureen Swanson
BACKGROUND Children are routinely exposed to chemicals known or suspected of harming brain development. Targeting Environmental Neuro-Development Risks (Project TENDR), an alliance of >50 leading scientists, health professionals, and advocates, is working to protect children from these toxic chemicals and pollutants, especially the disproportionate exposures experienced by children from families with
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Invited Perspective: Still Beating the Drum-Environmental Health Disparities and Neurodevelopment. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-27 Aisha S Dickerson
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Exposure to Perfluoroalkyl Substances and Associations with Pubertal Onset and Serum Reproductive Hormones in a Longitudinal Study of Young Girls in Greater Cincinnati and the San Francisco Bay Area. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-26 Susan M Pinney,Cecily S Fassler,Gayle C Windham,Robert L Herrick,Changchun Xie,Lawrence H Kushi,Frank M Biro
BACKGROUND Per- and polyfluoroalkyl substances (PFAS), endocrine disrupting chemicals with worldwide exposure, cause changes in mammary gland development in rodents. A few human studies report delay in pubertal events with increasing perfluorooctanoic acid (PFOA) exposure, but to our knowledge none have examined reproductive hormone levels at thelarche. METHODS In a cohort of Greater Cincinnati (GC)
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Invited Perspective: PFAS and Pubertal Timing in Girls-A Maturing Literature. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-26 Emily S Barrett,Zorimar Rivera-Núñez
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Response to "Comment on 'Adoption of Point-of-Use Chlorination for Household Drinking Water Treatment: A Systematic Review'". Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-26 Yoshika S Crider,Isha Ray,Amy J Pickering
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In Utero Exposure to Metals and Birth Outcomes in an Artisanal and Small-Scale Gold Mining Birth Cohort in Madre de Dios, Peru. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-25 Axel J Berky,Caren Weinhouse,Joao Vissoci,Nelson Rivera,Ernesto J Ortiz,Susy Navio,J Jaime Miranda,Andres Mallipudi,Emma Fixen,Heileen Hsu-Kim,William K Pan
BACKGROUND Few birth cohorts in South America evaluate the joint effect of minerals and toxic metals on neonatal health. In Madre de Dios, Peru, mercury exposure is prevalent owing to artisanal gold mining, yet its effect on neonatal health is unknown. OBJECTIVES We aimed to determine whether toxic metals are associated with lower birth weight and shorter gestational age independently of antenatal
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Invited Perspective: An Argument for Changing the Reporting Units for Lead in Blood. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-25 Jack Caravanos,Julianne Nassif,Bruce Lanphear,Philip J Landrigan,Howard Hu,Richard Fuller
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Untested, Unsafe? Cannabis Users Show Higher Lead and Cadmium Levels. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-25 Nate Seltenrich
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Guest Editorial: Focusing on What Matters Most-Impact. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-21 Richard Fuller,David Hanrahan,Ernesto Sanchez-Triana,Janez Potočnik,Robert Watson
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Effect Modifications of Overhead-View and Eye-Level Urban Greenery on Heat-Mortality Associations: Small-Area Analyses Using Case Time Series Design and Different Greenery Measurements. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-20 Jinglu Song,Antonio Gasparrini,Thomas Fischer,Kejia Hu,Yi Lu
BACKGROUND The protective effect of urban greenery from adverse heat impacts remains inconclusive. Existing inconsistent findings could be attributed to the different estimation techniques used. OBJECTIVES We investigated how effect modifications of urban greenery on heat-mortality associations vary when using different greenery measurements reflecting overhead-view and eye-level urban greenery. METHODS
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Evaluating Neighborhood-Level Differences in Hair Product Safety by Environmental Working Group Ratings among Retailers in Boston, Massachusetts. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-13 Marissa Chan,Shivani Parikh,Derek Shyr,Bhavna Shamasunder,Gary Adamkiewicz,Tamarra James-Todd
BACKGROUND Personal care products are a notable source of exposure to endocrine-disrupting chemicals (EDCs). Racial/ethnic differences in the use of hair products containing EDCs are reported, with women and children of color more commonly using hair products that are hormonally active and contain EDCs than other racial/ethnic groups. There is limited research examining the neighborhood-level social
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Urinary Paraben Concentrations and Associations with the Periconceptional Urinary Metabolome: Untargeted and Targeted Metabolomics Analyses of Participants from the Early Pregnancy Study. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-13 Ana K Rosen Vollmar,Nicholas J W Rattray,Yuping Cai,Abhishek Jain,Hong Yan,Nicole C Deziel,Antonia M Calafat,Allen J Wilcox,Anne Marie Z Jukic,Caroline H Johnson
BACKGROUND Parabens, found in everyday items from personal care products to foods, are chemicals with endocrine-disrupting activity, which has been shown to influence reproductive function. OBJECTIVES This study investigated whether urinary concentrations of methylparaben, propylparaben, or butylparaben were associated with the urinary metabolome during the periconceptional period, a critical window
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Escape from Sargasso Sea: Tremendous Sargassum Blooms Challenge Caribbean and Atlantic Communities. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-12 Charles Schmidt
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Effects of Gestational Arsenic Exposures on Placental and Fetal Development in Mice: The Role of Cyr61 m6A. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-08 Ya-Ping Song,Jin-Wei Lv,Zhi-Cheng Zhang,Qing-Hua Qian,Yi-Jun Fan,Dao-Zhen Chen,Heng Zhang,Fei-Xiang Xu,Cheng Zhang,Yichao Huang,Hua Wang,Wei Wei,De-Xiang Xu
BACKGROUND Several epidemiological investigations demonstrated that maternal arsenic (As) exposure elevated risk of fetal growth restriction (FGR), but the mechanism remains unclear. OBJECTIVES This study aimed to investigate the effects of gestational As exposure on placental and fetal development and its underlying mechanism. METHODS Dams were exposed to 0.15, 1.5, and 15mg/L NaAsO2 throughout pregnancy
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The Effect of Individual or Study-Wide Report-Back on Knowledge, Concern, and Exposure-Reducing Behaviors Related to Endocrine-Disrupting Chemicals. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-08 Katherine E Boronow,Barbara Cohn,Laurie Havas,Marj Plumb,Julia Green Brody
BACKGROUND To make informed decisions about endocrine-disrupting chemicals (EDCs), people need functional understanding of exposures and health and an ability to act on their knowledge. The return of biomonitoring results is an opportunity to educate people about EDCs and motivate exposure reduction. OBJECTIVES This study investigates environmental health knowledge about EDCs, concerns about health
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Invited Perspective: Making the Implicit Explicit-Connecting Environmental Health Literacy and Exposure Report-Back. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-08 Anna Goodman Hoover
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Associations between Urinary Concentrations of Disinfection Byproducts and in Vitro Fertilization Outcomes: A Prospective Cohort Study in China. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-06 Yan-Ling Deng,Chong Liu,Xiao-Qiong Yuan,Qiong Luo,Yu Miao,Pan-Pan Chen,Fei-Peng Cui,Min Zhang,Jia-Yue Zeng,Tian Shi,Ting-Ting Lu,Yu-Feng Li,Wen-Qing Lu,Qiang Zeng
BACKGROUND Experimental studies show that disinfection byproducts (DBPs) can inhibit oocyte maturation, decrease fertilization capacity, and impair embryo development, but human evidence is lacking. OBJECTIVES We aimed to evaluate the associations between exposure to drinking water DBPs and in vitro fertilization (IVF) outcomes. METHODS The study included 1,048 women undergoing assisted reproductive
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Effects of Early Life Oral Arsenic Exposure on Intestinal Tract Development and Lipid Homeostasis in Neonatal Mice: Implications for NAFLD Development. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-09-05 Xiaojing Yang,André A Weber,Elvira Mennillo,Patrick Secrest,Max Chang,Samantha Wong,Sabrina Le,Junlai Liu,Christopher W Benner,Michael Karin,Philip L S M Gordts,Robert H Tukey,Shujuan Chen
BACKGROUND Newborns can be exposed to inorganic arsenic (iAs) through contaminated drinking water, formula, and other infant foods. Epidemiological studies have demonstrated a positive association between urinary iAs levels and the risk of developing nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults. OBJECTIVES The present study examined how oral iAs administration to neonatal
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Prenatal Exposure to Toxic Metals and Neural Tube Defects: A Systematic Review of the Epidemiologic Evidence. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-30 Lauren A Eaves,Giehae Choi,Emily Hall,Fenna C M Sillé,Rebecca C Fry,Jessie P Buckley,Alexander P Keil
BACKGROUND Neural tube defects (NTDs) affect >300,000 pregnancies worldwide annually. Few nongenetic factors, other than folate deficiency, have been identified that may provide intervenable solutions to reduce the burden of NTDs. Prenatal exposure to toxic metals [arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn) and lead (Pb)] may increase the risk of NTDs. Although a growing epidemiologic
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Bearing the Brunt: Who Breathes the Air Pollutants from Hog CAFOs in North Carolina? Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-30 Silke Schmidt
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Blood and Urinary Metal Levels among Exclusive Marijuana Users in NHANES (2005-2018). Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-30 Katlyn E McGraw,Anne E Nigra,Joshua Klett,Marisa Sobel,Elizabeth C Oelsner,Ana Navas-Acien,Xin Hu,Tiffany R Sanchez
BACKGROUND Marijuana is the third most used drug in the world. OBJECTIVES Because the cannabis plant is a known scavenger of metals, we hypothesized that individuals who use marijuana will have higher metal biomarker levels compared with those who do not use. METHODS We combined data from the National Health and Nutrition Examination Survey (2005-2018) for n=7,254 participants, classified by use:
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Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent? Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-28 Jay S Schneider
BACKGROUND Childhood lead poisoning remains an important public health issue in the United States, as well as elsewhere in the world. Although primary prevention is a major goal and it is critically important to keep children from getting poisoned, it is also important to explore ways to reduce the neurotoxic effects of lead in those children already poisoned. Whether lead-induced neurotoxicity and
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Health Effects of Cyclones: A Systematic Review and Meta-Analysis of Epidemiological Studies. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-28 Wenzhong Huang,Yuan Gao,Rongbin Xu,Zhengyu Yang,Pei Yu,Tingting Ye,Elizabeth A Ritchie,Shanshan Li,Yuming Guo
BACKGROUND More intense cyclones are expected in the future as a result of climate change. A comprehensive review is urgently needed to summarize and update the evidence on the health effects of cyclones. OBJECTIVES We aimed to provide a systematic review with meta-analysis of current evidence on the risks of all reported health outcomes related to cyclones and to identify research gaps and make recommendations
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Invited Perspective: Challenging the Dogma of Lead Neurotoxicity. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-28 Tomás R Guilarte
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Modeling and Analysis of Air Pollution and Environmental Justice: The Case for North Carolina's Hog Concentrated Animal Feeding Operations. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-24 Brandon M Lewis,William H Battye,Viney P Aneja,Honghyok Kim,Michelle L Bell
BACKGROUND Concentrated animal feeding operations (CAFOs) emit pollutants that can cause negative impacts on human health. The concentration of hog production in North Carolina raises concerns regarding the disproportionate exposure of vulnerable communities to air pollution from CAFOs. OBJECTIVES We investigated whether exposure to gaseous ammonia (NH3) and hydrogen sulfide (H2S) (in 2019) differs
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Midpregnancy Phthalate and Phenol Biomarkers in Relation to Infant Body Composition: The Healthy Start Prospective Cohort. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-24 Danielle R Stevens,Anne P Starling,Paige A Bommarito,Alexander P Keil,Dorothy Nakiwala,Antonia M Calafat,John L Adgate,Dana Dabelea,Kelly K Ferguson
BACKGROUND Gestational phthalate and phenol exposure disrupts adipogenesis, contributing to obesity in mice. Whether gestational phthalate or phenol exposure is associated with infant body composition has not been investigated in humans. OBJECTIVE We examined associations between biomarkers of phthalate and phenol exposure in midpregnancy and infant size and body composition at birth and at 5 months
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Cold Spells and the Onset of Acute Myocardial Infarction: A Nationwide Case-Crossover Study in 323 Chinese Cities. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-23 Yixuan Jiang,Shaodong Yi,Chuanyu Gao,Yuguo Chen,Jiyan Chen,Xianghua Fu,Lixia Yang,Xiangqing Kong,Mao Chen,Haidong Kan,Dingcheng Xiang,Xi Su,Renjie Chen
BACKGROUND Few studies have explored the relationships between cold spells and acute myocardial infarction (AMI) using the information of symptom onset. OBJECTIVES We assessed the impact of cold spells on AMI onset and the potential effect modifiers. METHODS We conducted a time-stratified case-crossover study among 456,051 eligible patients with AMI from 2,054 hospitals in 323 Chinese cities between
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Toward Language Justice in Environmental Health Sciences in the United States: A Case for Spanish as a Language of Science. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-23 Yoshira Ornelas Van Horne,Laura M Diaz,Jessica Trowbridge,Cecilia S Alcala,David J X González
BACKGROUND Increasingly, marginalized communities are disproportionately facing the worsening effects of environmental hazards, including air pollution, water pollution, and climate change. Language isolation and accessibility has been understudied as a determinant of health. Spanish, despite being the second-most common language in the United States with some 41.8 million speakers, has been neglected
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Fetal Organophosphate Pesticide Exposure and Child Adiposity Measures at 10 Years of Age in the General Dutch Population. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-22 Sophia M Blaauwendraad,Danielle R Stevens,Michiel A van den Dries,Romy Gaillard,Anjoeka Pronk,Suzanne Spaan,Kelly K Ferguson,Vincent W V Jaddoe
BACKGROUND Fetal exposure to organophosphate (OP) pesticides might lead to fetal metabolic adaptations, predisposing individuals to adverse metabolic profiles in later life. OBJECTIVE We examined the association of maternal urinary OP pesticide metabolite concentrations in pregnancy with offspring body mass index (BMI) and fat measures at 10 years of age. METHODS Between 2002 and 2006, we included
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The Direct and Indirect Influences of Interrelated Regional-Level Sociodemographic Factors on Heat-Attributable Mortality in Europe: Insights for Adaptation Strategies. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-22 Simon J Lloyd,Marcos Quijal-Zamorano,Hicham Achebak,Shakoor Hajat,Raya Muttarak,Erich Striessnig,Joan Ballester
BACKGROUND Heat is a significant cause of mortality, but impact patterns are heterogenous. Previous studies assessing such heterogeneity focused exclusively on risk rather than heat-attributable mortality burdens and assume predictors are independent. OBJECTIVES We assessed how four interrelated regional-level sociodemographic predictors-education, life expectancy, the ratio of older to younger people
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Ambient Air Pollutants and Olfaction among Women 50-79 Years of Age from the Sister Study. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-18 Zichun Cao,Aiwen Yang,Alexandra J White,Frank Purdy,Chenxi Li,Zhehui Luo,Aimee A D'Aloisio,Lourdes Suarez,Sandra Deming-Halverson,Jayant M Pinto,Jiu-Chiuan Chen,Emily J Werder,Joel D Kaufman,Dale P Sandler,Honglei Chen
BACKGROUND Poor olfaction is common in older adults and may have profound adverse implications on their health. However, little is known about the potential environmental contributors to poor olfaction. OBJECTIVE We investigated ambient fine particulate matter [PM ≤2.5μm in aerodynamic diameter (PM2.5)] and nitrogen dioxide (NO2) in relation to poor olfaction in middle-aged to older women. METHODS
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Quantitative Microbial Risk Assessment of Contracting COVID-19 Derived from Measured and Simulated Aerosol Particle Transmission in Aircraft Cabins. Environ. Health Perspect. (IF 10.4) Pub Date : 2023-08-17 Jack F Schijven,Theo van Veen,Christiaan Delmaar,Johan Kos,Lucie Vermeulen,Rui Roosien,Frank Verhoeven,Maarten Schipper,Bram Peerlings,Erwin Duizer,Jonathan Derei,Wim Lammen,Onno Bartels,Harmen van der Ven,Robert Maas,Ana Maria de Roda Husman
BACKGROUND SARS-CoV-2 can be effectively transmitted between individuals located in close proximity to each other for extended durations. Aircraft provide such conditions. Although high attack rates during flights were reported, little was known about the risk levels of aerosol transmission of SARS-CoV-2 in aircraft cabins. OBJECTIVES The major objective was to estimate the risk of contracting COVID-19