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  • Reversible data hiding exploiting Huffman encoding with dual images for IoMT based healthcare
    Comput. Commun. (IF 2.816) Pub Date : 2020-09-02
    Solihah Gull; Shabir A. Parah; Khan Muhammad

    Continuous technological progressions and huge investments are made for the realization of the various goals in the Internet of Things (IoT) driven networks. Internet of Medical Things (IoMT) being a part of IoT has made human living smarter. It is revolutionizing the healthcare industry and is providing a smarter healthcare framework to the people. The generic IoMT framework consists of the major

    更新日期:2020-09-23
  • Identifying noisy labels with a transductive semi-supervised leave-one-out filter
    Pattern Recogn. Lett. (IF 3.255) Pub Date : 2020-09-23
    Bruno Klaus de Aquino Afonso; Lilian Berton

    Obtaining data with meaningful labels is often costly and error-prone. In this situation, semi-supervised learning (SSL) approaches are interesting, as they leverage assumptions about the unlabeled data to make up for the limited amount of labels. However, in real-world situations, we cannot assume that the labeling process is infallible, and the accuracy of many SSL classifiers decreases significantly

    更新日期:2020-09-23
  • Thermal Infrared Pedestrian Tracking Using Joint Siamese Network and Exemplar Prediction Model
    Pattern Recogn. Lett. (IF 3.255) Pub Date : 2020-09-23
    Liying Zheng; Shuo Zhao; Yanbo Zhang; Lei Yu

    Tracking pedestrian targets over a thermal infrared (TIR) image sequence is a hot topic in visual tracking. The imagery characteristics of TIR targets such as low target-background contrast and far imaging distance make TIR object tracking very difficult. In this paper, based on a convolutional neural network (CNN) and the siamese region proposal network (SiamRPN), we design an improved TIR pedestrian

    更新日期:2020-09-23
  • Safe Functional Systems through Integrity Types and Verified Assembly
    Theor. Comput. Sci. (IF 0.747) Pub Date : 2020-09-23
    Michael Christensen; Joseph McMahan; Lawton Nichols; Jared Roesch; Ben Hardekopf; Timothy Sherwood

    Building a trustworthy life-critical embedded system requires deep reasoning about the potential effects that sequences of machine instructions can have on full system operation. Rather than trying to analyze complete binaries and the countless ways their instructions can interact with one another — memory, side effects, control registers, implicit state, etc. — we explore a new approach. We propose

    更新日期:2020-09-23
  • Lightweight image classifier using dilated and depthwise separable convolutions
    J. Cloud Comp. (IF 2.788) Pub Date : 2020-09-23
    Wei Sun; Xiaorui Zhang; Xiaozheng He

    The image classification based on cloud computing suffers from difficult deployment as the network depth and data volume increase. Due to the depth of the model and the convolution process of each layer will produce a great amount of calculation, the GPU and storage performance of the device are extremely demanding, and the GPU and storage devices equipped on the embedded and mobile terminals cannot

    更新日期:2020-09-23
  • A weight-based conditional privacy-preserving authentication scheme in software-defined vehicular network
    J. Cloud Comp. (IF 2.788) Pub Date : 2020-09-23
    Hong Zhong; Yingxue Geng; Jie Cui; Yan Xu; Lu Liu

    The rapid development of vehicular ad hoc networks (VANETs) has brought significant improvement to traffic safety and efficiency. However, owing to limitations associated with VANETs’ own unchanging model and traditional network structure, there are still many challenging concerns such as poor flexibility and controllability to deal with. To solve these inherent problems effectively, we propose a weight-based

    更新日期:2020-09-23
  • Categorizing Malware via A Word2Vec-based Temporal Convolutional Network Scheme
    J. Cloud Comp. (IF 2.788) Pub Date : 2020-09-23
    Jiankun Sun; Xiong Luo; Honghao Gao; Weiping Wang; Yang Gao; Xi Yang

    As edge computing paradigm achieves great popularity in recent years, there remain some technical challenges that must be addressed to guarantee smart device security in Internet of Things (IoT) environment. Generally, smart devices transmit individual data across the IoT for various purposes nowadays, and it will cause losses and impose a huge threat to users since malware may steal and damage these

    更新日期:2020-09-23
  • Development of an early warning system for loose automobile tires
    Sci. Progess (IF 1.906) Pub Date : 2020-09-22
    Huibo Wu; Fei Song; Kainan Wu; Cheng Chen; Xiaohua Wang

    The looseness of tires or even falling off from cars will lead to serious traffic accidents. Once it occurs, it will bring casualties and huge economic losses to society, seriously affecting the traffic safety. To mitigate such possible safety concerns, an early loosening warning system is developed in this article. The system consists of the tire monitoring module and the working control module. The

    更新日期:2020-09-23
  • Equivalence checking of quantum finite-state machines
    J. Comput. Syst. Sci. (IF 1.494) Pub Date : 2020-09-17
    Qisheng Wang; Junyi Liu; Mingsheng Ying

    In this paper, we introduce the model of quantum Mealy machines and study the equivalence checking and minimisation problems of them. Two efficient algorithms are developed for checking equivalence of two states in the same machine and for checking equivalence of two machines. As an application, they are used in equivalence checking of quantum circuits. Moreover, the minimisation problem is proved

    更新日期:2020-09-23
  • Applicability of mobile contact tracing in fighting pandemic (COVID-19): Issues, challenges and solutions
    Comput. Sci. Rev. (IF 7.707) Pub Date : 2020-09-23
    Aaqib Bashir Dar; Auqib Hamid Lone; Saniya Zahoor; Afshan Amin Khan; Roohie Naaz

    Contact Tracing is considered as the first and the most effective step towards containing an outbreak, as resources for mass testing and large quantity of vaccines are highly unlikely available for immediate utilization. Effective contact tracing can allow societies to reopen from lock-down even before availability of vaccines. The objective of mobile contact tracing is to speed up the manual interview

    更新日期:2020-09-23
  • Learning distinctive filters for COVID-19 detection from chest X-ray using shuffled residual CNN
    Appl. Soft Comput. (IF 5.472) Pub Date : 2020-09-23
    R. Karthik; R. Menaka; Hariharan M.

    COVID-19 is a deadly viral infection that has brought a significant threat to human lives. Automatic diagnosis of COVID-19 from medical imaging enables precise medication, helps to control community outbreak, and reinforces coronavirus testing methods in place. While there exist several challenges in manually inferring traces of this viral infection from X-ray, Convolutional Neural Network (CNN) can

    更新日期:2020-09-23
  • Efficient Identification of k-Closed Strings
    Int. J. Found. Comput. Sci. (IF 0.523) Pub Date : 2020-08-26
    Hayam Alamro; Mai Alzamel; Costas S. Iliopoulos; Solon P. Pissis; Wing-Kin Sung; Steven Watts

    A closed string contains a proper factor occurring as both a prefix and a suffix but not elsewhere in the string. Closed strings were introduced by Fici (WORDS 2011) as objects of combinatorial interest. This paper addresses a new problem by extending the closed string problem to the k-closed string problem, for which a level of approximation is permitted up to a number of Hamming distance errors,

    更新日期:2020-09-23
  • A deep unrolling network inspired by total variation for compressed sensing MRI
    Digit. Signal Process. (IF 2.871) Pub Date : 2020-09-15
    Xiaohua Zhang; Qiusheng Lian; Yuchi Yang; Yueming Su

    Compressed Sensing theory breaks through the limitation of the Nyquist sampling law and provides theoretical support for accelerating the imaging process of MRI while reconstructing high-quality images. It can use less sampling data through the reconstructed algorithm to restore the original signal. Reconstruction time and reconstruction algorithms play important roles in compressed sensing. However

    更新日期:2020-09-23
  • A signal decomposition algorithm based on complex AM-FM model
    Digit. Signal Process. (IF 2.871) Pub Date : 2020-09-23
    De Zhu; Qingwei Gao; Yixiang Lu; Dong Sun

    Model-based adaptive signal decomposition algorithm is an important research topic in the field of signal analysis. The amplitude modulated and frequency modulated (AM-FM) model is the most common model in the signal. In this paper, an adaptive signal decomposition algorithm based on the complex AM-FM model is proposed. This algorithm first obtains the analytical expression of the analyzed signal;

    更新日期:2020-09-23
  • Low-complexity GLRT for FDA radar without training data
    Digit. Signal Process. (IF 2.871) Pub Date : 2020-09-22
    Ronghua Gui; Wen-Qin Wang; Zhi Zheng

    Conventionally adaptive detection for frequency diverse array (FDA) radar requires extra training data to estimate the range-dependent interference covariance matrix (ICM). In this paper, we propose an adaptive moving target detection approach for FDA radar without training data, where the ICM is directly estimated by applying a structured generalized likelihood ratio test (SGLRT) to the target-present

    更新日期:2020-09-23
  • Efficient Group ID-Based Encryption With Equality Test Against Insider Attack
    Comput. J. (IF 1.077) Pub Date : 2020-09-23
    Yunhao Ling; Sha Ma; Qiong Huang; Ximing Li; Yijian Zhong; Yunzhi Ling

    ID-based encryption with equality test (IBEET) allows a tester to compare ciphertexts encrypted under different public keys for checking whether they contain the same message. In this paper, we first introduce group mechanism into IBEET and propose a new primitive, namely group ID-based encryption with equality test (G-IBEET). With the group mechanism: (1) group administrator can authorize a tester

    更新日期:2020-09-23
  • Corrigendum to: Multi-Swarm Cuckoo Search Algorithm with Q-Learning Model
    Comput. J. (IF 1.077) Pub Date : 2020-09-23
    Juan Li; Dan-dan Xiao; Ting Zhang; Chun Liu; Yuan-xiang Li; Gai-ge Wang

    AbstractFunctional encryption (FE) can provide a fine-grained access control on the encrypted message. Therefore, it has been applied widely in security business. The previous works about functional encryptions most focused on the deterministic functions. The randomized algorithm has wide application, such as securely encryption algorithms against chosen ciphertext attack, privacy-aware auditing. Based

    更新日期:2020-09-23
  • Author Correction: Lactonization as a general route to β-C( sp 3 )–H functionalization
    Nature (IF 42.778) Pub Date : 2020-09-23
    Zhe Zhuang; Jin-Quan Yu

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-23
  • Author Correction: Floating under a levitating liquid
    Nature (IF 42.778) Pub Date : 2020-09-23
    Benjamin Apffel; Filip Novkoski; Antonin Eddi; Emmanuel Fort

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-23
  • Unsustainable charcoal, COVID spreads on plane and antibody cocktails
    Nature (IF 42.778) Pub Date : 2020-09-23

    The latest science news, in brief.

    更新日期:2020-09-23
  • Science and the US presidential election: what do you think?
    Nature (IF 42.778) Pub Date : 2020-09-23

    Nature is tracking what readers care about most in the 2020 election.

    更新日期:2020-09-23
  • After decades of trying, scientists coax plastic particles into a diamond-like structure
    Nature (IF 42.778) Pub Date : 2020-09-23
    Benjamin Thompson; Nick Howe

    Hear the biggest stories from the world of science | 24 September 2020

    更新日期:2020-09-23
  • Precision oncology
    Nature (IF 42.778) Pub Date : 2020-09-23
    Richard Hodson

    Cancer treatments that target the characteristics of an individual's tumour could have a wider impact.

    更新日期:2020-09-23
  • SARS-CoV-2 vaccines in development
    Nature (IF 42.778) Pub Date : 2020-09-23
    Florian Krammer

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019 in China and caused a coronavirus disease 2019 (COVID-19) pandemic. To mitigate the public health, economic and societal impacts of the virus, a vaccine is urgently needed. The development of SARS-CoV-2 vaccines was initiated in early January 2020 when the sequence of the virus became available and moved at record speed

    更新日期:2020-09-23
  • Twitter followers’ details reveal the power of a paper
    Nature (IF 42.778) Pub Date : 2020-09-23

    Tweets about biology preprints generally come from members of the academic community — but politics also plays a part.

    更新日期:2020-09-23
  • Diversity in science: next steps for research group leaders
    Nature (IF 42.778) Pub Date : 2020-09-23
    Nikki Forrester

    Many institutions publicly pledged their commitment to inclusion after Black Lives Matter protests this year. And researchers emphasize the need to maintain momentum.

    更新日期:2020-09-23
  • The first-ever image of a black hole is now a movie
    Nature (IF 42.778) Pub Date : 2020-09-23
    Davide Castelvecchi

    Pictures created from old observations show the void’s stormy evolution over the past decade.

    更新日期:2020-09-23
  • Animal models for COVID-19
    Nature (IF 42.778) Pub Date : 2020-09-23
    César Muñoz-Fontela; William E. Dowling; Simon G. P. Funnell; Pierre-S Gsell; Ximena Riveros Balta; Randy A. Albrecht; Hanne Andersen; Ralph S. Baric; Miles W. Carroll; Marco Cavaleri; Chuan Qin; Ian Crozier; Kai Dallmeier; Leon de Waal; Emmie de Wit; Leen Delang; Erik Dohm; W. Paul Duprex; Darryl Falzarano; Courtney L. Finch; Matthew B. Frieman; Barney S. Graham; Lisa Gralinski; Kate Guilfoyle; Bart

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by introduction of a novel coronavirus into humans in late 2019 in China’s Hubei province. As of September 11, 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 28 million people, and has caused more than 910,000 deaths

    更新日期:2020-09-23
  • Encounters with inequality lead to demands for taxes on the rich
    Nature (IF 42.778) Pub Date : 2020-09-23
    Colin Tredoux; John Dixon

    Local exposure to inequality leads to demands for wealth distribution.

    更新日期:2020-09-23
  • Making radiation oncology more personal
    Nature (IF 42.778) Pub Date : 2020-09-23
    Amanda B. Keener

    The technology to fine-tune radiotherapy to an individual is here, but a lack of research is holding back its use.

    更新日期:2020-09-23
  • Elusive photonic crystals come a step closer
    Nature (IF 42.778) Pub Date : 2020-09-23
    John C. Crocker

    Key step towards production of 3D photonic bandgap crystals.

    更新日期:2020-09-23
  • Building better CAR-T therapies
    Nature (IF 42.778) Pub Date : 2020-09-23
    Anthony King

    The current technique requires a person’s own cells, but using the cells of healthy donors could allow more people to benefit.

    更新日期:2020-09-23
  • An intersection of parallel lives
    Nature (IF 42.778) Pub Date : 2020-09-23
    Wendy Nikel

    A rescue mission like no other.

    更新日期:2020-09-23
  • Daily briefing: Brazilian city might show what happens when COVID-19 runs almost unchecked
    Nature (IF 42.778) Pub Date : 2020-09-23
    Flora Graham

    Up to one in 800 people in the city of Manaus, Brazil, is estimated to have died of COVID-19. Plus, Arctic sea ice hits another low and the black hole image is now a movie.

    更新日期:2020-09-23
  • Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance
    Nature (IF 42.778) Pub Date : 2020-09-23
    Daniel J. Blair; Martin D. Burke

    A resistance-evading streptogramin antibiotic.

    更新日期:2020-09-23
  • Health-care inequality could deepen with precision oncology
    Nature (IF 42.778) Pub Date : 2020-09-23
    Jyoti Madhusoodanan

    Failure to address systemic bias in health-care provision and genetic databases will make existing disparities worse.

    更新日期:2020-09-23
  • The potential of real-world data
    Nature (IF 42.778) Pub Date : 2020-09-23
    Anna Nowogrodzki

    Janssen’s Craig Tendler talks to Nature about how data collected by the company after a drug is approved can be used to improve treatment.

    更新日期:2020-09-23
  • Third-order nanocircuit elements for neuromorphic engineering
    Nature (IF 42.778) Pub Date : 2020-09-23
    Suhas Kumar; R. Stanley Williams; Ziwen Wang

    Current hardware approaches to biomimetic or neuromorphic artificial intelligence rely on elaborate transistor circuits to simulate biological functions. However, these can instead be more faithfully emulated by higher-order circuit elements that naturally express neuromorphic nonlinear dynamics1,2,3,4. Generating neuromorphic action potentials in a circuit element theoretically requires a minimum

    更新日期:2020-09-23
  • Online learning cannot just be for those who can afford its technology
    Nature (IF 42.778) Pub Date : 2020-09-23

    The dramatic shift to online learning as a result of the COVID-19 pandemic risks widening educational inequalities.

    更新日期:2020-09-23
  • Maternal microbes support fetal brain wiring
    Nature (IF 42.778) Pub Date : 2020-09-23
    Katherine R. Meckel; Drew D. Kiraly

    Metabolites made by bacteria signal to the developing mouse brain.

    更新日期:2020-09-23
  • The RNA and protein landscape that could bring precision medicine to more people
    Nature (IF 42.778) Pub Date : 2020-09-23
    Simon Makin

    The limitations of genomic data have led to a deeper exploration of transcriptomic and proteomic data in cancer.

    更新日期:2020-09-23
  • Research round-up: Precision oncology
    Nature (IF 42.778) Pub Date : 2020-09-23

    Targeted treatments for children, a fresh approach to protein analysis and other highlights from clinical trials and laboratory studies.

    更新日期:2020-09-23
  • The future of tissue-agnostic drugs
    Nature (IF 42.778) Pub Date : 2020-09-23
    Julianna Photopoulos

    Some people with cancer are already benefiting from drugs that target genetic features regardless of the tissue involved. But these early successes could be the exceptions.

    更新日期:2020-09-23
  • The hysteresis of the Antarctic Ice Sheet
    Nature (IF 42.778) Pub Date : 2020-09-23
    Julius Garbe; Torsten Albrecht; Anders Levermann; Jonathan F. Donges; Ricarda Winkelmann

    More than half of Earth’s freshwater resources are held by the Antarctic Ice Sheet, which thus represents by far the largest potential source for global sea-level rise under future warming conditions1. Its long-term stability determines the fate of our coastal cities and cultural heritage. Feedbacks between ice, atmosphere, ocean, and the solid Earth give rise to potential nonlinearities in its response

    更新日期:2020-09-23
  • Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
    Nature (IF 42.778) Pub Date : 2020-09-23
    Keith A. Lawson; Cristovão M. Sousa; Xiaoyu Zhang; Eiru Kim; Rummy Akthar; Joseph J. Caumanns; Yuxi Yao; Nicholas Mikolajewicz; Catherine Ross; Kevin R. Brown; Abdelrahman Abou Zid; Zi Peng Fan; Shirley Hui; Jordan A. Krall; Donald M. Simons; Chloe J. Slater; Victor De Jesus; Lujia Tang; Richa Singh; Joshua E. Goldford; Sarah Martin; Qian Huang; Elizabeth A. Francis; Andrea Habsid; Ryan Climie; David

    The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood1,2,3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic T lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured

    更新日期:2020-09-23
  • Hippocampal CA2 sharp-wave ripples reactivate and promote social memory
    Nature (IF 42.778) Pub Date : 2020-09-23
    Azahara Oliva; Antonio Fernández-Ruiz; Felix Leroy; Steven A. Siegelbaum

    The consolidation of spatial memory depends on the reactivation (‘replay’) of hippocampal place cells that were active during recent behaviour. Such reactivation is observed during sharp-wave ripples (SWRs)—synchronous oscillatory electrical events that occur during non-rapid-eye-movement (non-REM) sleep1,2,3,4,5,6,7,8 and whose disruption impairs spatial memory3,5,6,8. Although the hippocampus also

    更新日期:2020-09-23
  • Colloidal diamond
    Nature (IF 42.778) Pub Date : 2020-09-23
    Mingxin He; Johnathon P. Gales; Étienne Ducrot; Zhe Gong; Gi-Ra Yi; Stefano Sacanna; David J. Pine

    Self-assembling colloidal particles in the cubic diamond crystal structure could potentially be used to make materials with a photonic bandgap1,2,3. Such materials are beneficial because they suppress spontaneous emission of light1 and are valued for their applications as optical waveguides, filters and laser resonators4, for improving light-harvesting technologies5,6,7 and for other applications4

    更新日期:2020-09-23
  • Conformation of sister chromatids in the replicated human genome
    Nature (IF 42.778) Pub Date : 2020-09-23
    Michael Mitter; Catherina Gasser; Zsuzsanna Takacs; Christoph C. H. Langer; Wen Tang; Gregor Jessberger; Charlie T. Beales; Eva Neuner; Stefan L. Ameres; Jan-Michael Peters; Anton Goloborodko; Ronald Micura; Daniel W. Gerlich

    The three-dimensional organization of the genome supports regulated gene expression, recombination, DNA repair, and chromosome segregation during mitosis. Chromosome conformation capture (Hi-C)1,2 analysis has revealed a complex genomic landscape of internal chromosomal structures in vertebrate cells3,4,5,6,7, but the identical sequence of sister chromatids has made it difficult to determine how they

    更新日期:2020-09-23
  • Local exposure to inequality raises support of people of low wealth for taxing the wealthy
    Nature (IF 42.778) Pub Date : 2020-09-23
    Melissa L. Sands; Daniel de Kadt

    Psychological research shows that social comparison of individuals with peers or others shapes attitude formation1,2. Opportunities for such comparisons have increased with global inequality3,4; everyday experiences can make economic disparities more salient through signals of social class5,6. Here we show that, among individuals with a lower socioeconomic status, such local exposure to inequality

    更新日期:2020-09-23
  • Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B
    Nature (IF 42.778) Pub Date : 2020-09-23
    Ting-Hai Xu; Minmin Liu; X. Edward Zhou; Gangning Liang; Gongpu Zhao; H. Eric Xu; Karsten Melcher; Peter A. Jones

    CpG methylation by de novo DNA methyltransferases (DNMTs) 3A and 3B is essential for mammalian development and differentiation and is frequently dysregulated in cancer1. These two DNMTs preferentially bind to nucleosomes, yet cannot methylate the DNA wrapped around the nucleosome core2, and they favour the methylation of linker DNA at positioned nucleosomes3,4. Here we present the cryo-electron microscopy

    更新日期:2020-09-23
  • Fractional antiferromagnetic skyrmion lattice induced by anisotropic couplings
    Nature (IF 42.778) Pub Date : 2020-09-23
    Shang Gao; H. Diego Rosales; Flavia A. Gómez Albarracín; Vladimir Tsurkan; Guratinder Kaur; Tom Fennell; Paul Steffens; Martin Boehm; Petr Čermák; Astrid Schneidewind; Eric Ressouche; Daniel C. Cabra; Christian Rüegg; Oksana Zaharko

    Magnetic skyrmions are topological solitons with a nanoscale winding spin texture that hold promise for spintronics applications1,2,3,4. Skyrmions have so far been observed in a variety of magnets that exhibit nearly parallel alignment for neighbouring spins, but theoretically skyrmions with anti-parallel neighbouring spins are also possible. Such antiferromagnetic skyrmions may allow more flexible

    更新日期:2020-09-23
  • Initiation of a conserved trophectoderm program in human, cow and mouse embryos
    Nature (IF 42.778) Pub Date : 2020-09-23
    Claudia Gerri; Afshan McCarthy; Gregorio Alanis-Lobato; Andrej Demtschenko; Alexandre Bruneau; Sophie Loubersac; Norah M. E. Fogarty; Daniel Hampshire; Kay Elder; Phil Snell; Leila Christie; Laurent David; Hilde Van de Velde; Ali A. Fouladi-Nashta; Kathy K. Niakan

    Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) placental progenitor program. The inner cell mass arises from inner cells during subsequent developmental stages and comprises precursor cells of the embryo

    更新日期:2020-09-23
  • Synthetic group A streptogramin antibiotics that overcome Vat resistance
    Nature (IF 42.778) Pub Date : 2020-09-23
    Qi Li; Jenna Pellegrino; D. John Lee; Arthur A. Tran; Hector A. Chaires; Ruoxi Wang; Jesslyn E. Park; Kaijie Ji; David Chow; Na Zhang; Axel F. Brilot; Justin T. Biel; Gydo van Zundert; Kenneth Borrelli; Dean Shinabarger; Cindy Wolfe; Beverly Murray; Matthew P. Jacobson; Estelle Mühle; Olivier Chesneau; James S. Fraser; Ian B. Seiple

    Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten the clinical lifetime of any given class of antibiotics1. Virginiamycin acetyltransferase (Vat) enzymes are resistance proteins that provide protection against streptogramins2,

    更新日期:2020-09-23
  • Mapping carbon accumulation potential from global natural forest regrowth
    Nature (IF 42.778) Pub Date : 2020-09-23
    Susan C. Cook-Patton; Sara M. Leavitt; David Gibbs; Nancy L. Harris; Kristine Lister; Kristina J. Anderson-Teixeira; Russell D. Briggs; Robin L. Chazdon; Thomas W. Crowther; Peter W. Ellis; Heather P. Griscom; Valentine Herrmann; Karen D. Holl; Richard A. Houghton; Cecilia Larrosa; Guy Lomax; Richard Lucas; Palle Madsen; Yadvinder Malhi; Alain Paquette; John D. Parker; Keryn Paul; Devin Routh; Stephen

    To constrain global warming, we must strongly curtail greenhouse gas emissions and capture excess atmospheric carbon dioxide1,2. Regrowing natural forests is a prominent strategy for capturing additional carbon3, but accurate assessments of its potential are limited by uncertainty and variability in carbon accumulation rates2,3. To assess why and where rates differ, here we compile 13,112 georeferenced

    更新日期:2020-09-23
  • The maternal microbiome modulates fetal neurodevelopment in mice
    Nature (IF 42.778) Pub Date : 2020-09-23
    Helen E. Vuong; Geoffrey N. Pronovost; Drake W. Williams; Elena J. L. Coley; Emily L. Siegler; Austin Qiu; Maria Kazantsev; Chantel J. Wilson; Tomiko Rendon; Elaine Y. Hsiao

    ‘Dysbiosis’ of the maternal gut microbiome, in response to challenges such as infection1, altered diet2 and stress3 during pregnancy, has been increasingly associated with abnormalities in brain function and behaviour of the offspring4. However, it is unclear whether the maternal gut microbiome influences neurodevelopment during critical prenatal periods and in the absence of environmental challenges

    更新日期:2020-09-23
  • Light-driven post-translational installation of reactive protein side chains
    Nature (IF 42.778) Pub Date : 2020-09-23
    Brian Josephson; Charlie Fehl; Patrick G. Isenegger; Simon Nadal; Tom H. Wright; Adeline W. J. Poh; Ben J. Bower; Andrew M. Giltrap; Lifu Chen; Christopher Batchelor-McAuley; Grace Roper; Oluwatobi Arisa; Jeroen B. I. Sap; Akane Kawamura; Andrew J. Baldwin; Shabaz Mohammed; Richard G. Compton; Veronique Gouverneur; Benjamin G. Davis

    Post-translational modifications (PTMs) greatly expand the structures and functions of proteins in nature1,2. Although synthetic protein functionalization strategies allow mimicry of PTMs3,4, as well as formation of unnatural protein variants with diverse potential functions, including drug carrying5, tracking, imaging6 and partner crosslinking7, the range of functional groups that can be introduced

    更新日期:2020-09-23
  • Host–microbiota maladaptation in colorectal cancer
    Nature (IF 42.778) Pub Date : 2020-09-23
    Alina Janney; Fiona Powrie; Elizabeth H. Mann

    Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as diet, which is consistent with a growing body of literature that describes an ‘oncogenic’ CRC-associated microbiota. Whether this dysbiosis contributes

    更新日期:2020-09-23
  • Modulating TRADD to restore cellular homeostasis and inhibit apoptosis
    Nature (IF 42.778) Pub Date : 2020-09-23
    Daichao Xu; Heng Zhao; Minzhi Jin; Hong Zhu; Bing Shan; Jiefei Geng; Slawomir A. Dziedzic; Palak Amin; Lauren Mifflin; Masanori Gomi Naito; Ayaz Najafov; Jing Xing; Lingjie Yan; Jianping Liu; Ying Qin; Xinqian Hu; Huibing Wang; Mengmeng Zhang; Vica Jean Manuel; Li Tan; Zhuohao He; Zhenyu J. Sun; Virginia M. Y. Lee; Gerhard Wagner; Junying Yuan

    Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathological state. Although mechanisms of cell death have been thoroughly investigated1,2,3, it remains unclear how homeostasis can be restored after inhibition of cell death. Here we identify TRADD4

    更新日期:2020-09-23
  • Shared yet dissociable neural codes across eye gaze, valence and expectation
    Nature (IF 42.778) Pub Date : 2020-09-23
    Raviv Pryluk; Yosef Shohat; Anna Morozov; Dafna Friedman; Aryeh H. Taub; Rony Paz

    The direction of the eye gaze of others is a prominent social cue in primates and is important for communication1,2,3,4,5,6,7,8,9,10,11. Although gaze can signal threat and elicit anxiety6,12,13, it remains unclear whether it shares neural circuitry with stimulus value. Notably, gaze not only has valence, but can also serve as a predictor of the outcome of a social encounter, which can be either negative

    更新日期:2020-09-23
  • A frozen land goes green as Earth warms
    Nature (IF 42.778) Pub Date : 2020-09-22

    Climate change drives vegetation gains in patches of the high Arctic tundra.

    更新日期:2020-09-23
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