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Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis J. Adv. Res. (IF 10.7) Pub Date : 2024-03-12 Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo
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Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review J. Adv. Res. (IF 10.7) Pub Date : 2024-03-11 Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors J. Adv. Res. (IF 10.7) Pub Date : 2024-03-11 Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms J. Adv. Res. (IF 10.7) Pub Date : 2024-03-09 Yue Xiao, Yingxuan Feng, Jianxin Zhao, Wei Chen, Wenwei Lu
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours J. Adv. Res. (IF 10.7) Pub Date : 2024-03-07 Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael
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The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis J. Adv. Res. (IF 10.7) Pub Date : 2024-03-07 Junchao Wu, Lisha Li, Tingrui Zhang, Jiaye Lu, Zongguang Tai, Quangang Zhu, Zhongjian Chen
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Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity J. Adv. Res. (IF 10.7) Pub Date : 2024-03-03 Yazhou Bao, Qian Zhang, Hai Zhu, Yong Pei, Yaning Zhao, Yixin Li, Peiyun Ji, Dandan Du, Hao Peng, Guangyuan Xu, Xiaodan Wang, Zhiyuan Yin, Gan Ai, Xiangxiu Liang, Daolong Dou
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NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner J. Adv. Res. (IF 10.7) Pub Date : 2024-03-02 Tiange Lu, Juan Yang, Yiqing Cai, Mengfei Ding, Zhuoya Yu, Xiaosheng Fang, Xiangxiang Zhou, Xin Wang
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Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer J. Adv. Res. (IF 10.7) Pub Date : 2024-03-02 Jingyang Li, Di Zhang, Shaohui Wang, Peng Yu, Jiayi Sun, Yi Zhang, Xianli Meng, Juan Li, Li Xiang
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway J. Adv. Res. (IF 10.7) Pub Date : 2024-03-02 Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen
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Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides J. Adv. Res. (IF 10.7) Pub Date : 2024-03-01 Heqian Zhang, Yihan Wang, Yanran Zhu, Pengtao Huang, Qiandi Gao, Xiaojie Li, Zhaoying Chen, Yu Liu, Jiakun Jiang, Yuan Gao, Jiaquan Huang, Zhiwei Qin
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Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model J. Adv. Res. (IF 10.7) Pub Date : 2024-02-28 Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei
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MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology J. Adv. Res. (IF 10.7) Pub Date : 2024-02-27 Jin Wang, Jinyong Jiang, Haoliang Hu, Linxi Chen
The integral roles of the MCU complex in pathophysiological processes, and the relationship between agonists, inhibitors, and traditional Chinese medicine monomers related to the MCU complex.
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Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids J. Adv. Res. (IF 10.7) Pub Date : 2024-02-24 Yuxin Luo, Chenrui An, Ke Zhong, Ping Zhou, Dan Li, Hui Liu, Qing Guo, Wei Wei, Hen Pan, Zheying Min, Rong Li, Yang Yu, Yong Fan
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AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis J. Adv. Res. (IF 10.7) Pub Date : 2024-02-20 Wuping Tan, Yijun Wang, Siyi Cheng, Zhihao Liu, Mengjie Xie, Lingpeng Song, Qinfang Qiu, Xiaofei Wang, Zeyan Li, Tianyuan Liu, Fuding Guo, Jun Wang, Xiaoya Zhou
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Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice J. Adv. Res. (IF 10.7) Pub Date : 2024-02-20 Jia-Jin Wu, Xiaoyu Zheng, Caichi Wu, Wen Ma, Yibo Wang, Jun Wang, Yulong Wei, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen
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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy J. Adv. Res. (IF 10.7) Pub Date : 2024-02-18 Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu
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A narrative review about cognitive impairment in metabolic Dysfunction–Associated liver disease (MASLD): Another matter to face through a holistic approach J. Adv. Res. (IF 10.7) Pub Date : 2024-02-17 Marica Meroni, Miriam Longo, Erika Paolini, Paola Dongiovanni
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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity J. Adv. Res. (IF 10.7) Pub Date : 2024-02-15 Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna
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Recent advances in integrated solar cell/supercapacitor devices: Fabrication, strategy and perspectives J. Adv. Res. (IF 10.7) Pub Date : 2024-02-13 Qiaoling Zhang, Guodong Li, Fen Qiao
From the microscopic mechanism of different functional unit materials to the energy conversion and storage mechanism of macroscopic integrated devices, the design of highly efficient and stable integrated SCSD, the law of improving solar energy conversion and storage performance by supercapacitors and solar cell stacks were systematically discussed.
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Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction J. Adv. Res. (IF 10.7) Pub Date : 2024-02-11 Guoxing Li, Huilin Zhao, Zhe Cheng, Junjin Liu, Gang Li, Yongzheng Guo
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD J. Adv. Res. (IF 10.7) Pub Date : 2024-02-10 Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie
Cigarette smoke decreases DNA methylation level of GADD45B promoter in bronchial epithelial cell, thereby promotes GADD45B expression. Subsequently, GADD45B upregulation can directly promote release of inflammatory cytokines through phosphorylation of p38, and can also promote cell senescence by interacting with FOS, which furtherly aggravates inflammation via phosphorylating p38.
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High SERS performance of functionalized carbon dots in the detection of dye contaminants J. Adv. Res. (IF 10.7) Pub Date : 2024-02-09 Yanqiu Yang, Lingru Kong, Yong Ding, Lixin Xia, Shuo Cao, Peng Song
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Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease J. Adv. Res. (IF 10.7) Pub Date : 2024-02-09 Jinling Li, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin, Guiling Yang, Xin Zhang
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New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson’s disease J. Adv. Res. (IF 10.7) Pub Date : 2024-02-08 Silvana-Yanina Romero-Zerbo, Nadia Valverde, Silvia Claros, Pablo Zamorano-Gonzalez, Federica Boraldi, Francesco-Demetrio Lofaro, Estrella Lara, Jose Pavia, Maria Garcia-Fernandez, Belen Gago, Elisa Martin-Montañez
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Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor J. Adv. Res. (IF 10.7) Pub Date : 2024-02-08 Ke Sun, Yong-Li Wang, Chen-Chen Hou, Da Shang, Lin-Juan Du, Lan Bai, Xing-Yu Zhang, Chuan-Ming Hao, Sheng-Zhong Duan
Schematic illustration of NCOR1 function in collecting duct cells. Collecting duct NCOR1 is involved in BP regulation by interacting with MR and then down-regulating the expression of ENaC genes. Spironolactone or amiloride treatment ameliorates the exacerbating effects of collecting duct NCOR1 deficiency on hypertension.
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Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora J. Adv. Res. (IF 10.7) Pub Date : 2024-02-07 Qianqian Liu, Kexin Jiang, Shipeng Duan, Na Zhao, Yanmei Shen, Lirong Zhu, Ke-Qin Zhang, Jinkui Yang
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The future of plant based green carbon dots as cancer Nanomedicine: From current progress to future Perspectives and beyond J. Adv. Res. (IF 10.7) Pub Date : 2024-02-05 Hong Hui Jing, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Sreenivasan Sasidharan
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BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway J. Adv. Res. (IF 10.7) Pub Date : 2024-02-03 Wenying Sun, Yutian Lei, Zhihui Jiang, Kun Wang, Huanyi Liu, Tong Xu
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The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells J. Adv. Res. (IF 10.7) Pub Date : 2024-02-02 Xiaoyan Zhang, Meng Zhang, Hui Sun, Xu Wang, Xin Wang, Weiqi Sheng, Midie Xu
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Glycosidic linkages of fungus polysaccharides influence the anti-inflammatory activity in mice J. Adv. Res. (IF 10.7) Pub Date : 2024-02-02 Qin Yuan, Wen Liu, Wei Hao, Yi Chen, Yaqin Xiao, Hongyi Li, Mingju Shui, Ding-Tao Wu, Shengpeng Wang
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Studying changes in the dynamical patterns in two physical models involving new Caputo operator J. Adv. Res. (IF 10.7) Pub Date : 2024-02-02 A.E. Matouk
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Mechanisms and therapeutic implications of selective autophagy in nonalcoholic fatty liver disease J. Adv. Res. (IF 10.7) Pub Date : 2024-02-01 Suwei Jin, Yujia Li, Tianji Xia, Yongguang Liu, Shanshan Zhang, Hongbo Hu, Qi Chang, Mingzhu Yan
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Cellular and physiological functions of SGR family in gravitropic response in higher plants J. Adv. Res. (IF 10.7) Pub Date : 2024-02-01 Yuhan Cho, Yujeong Kim, Hyebi Lee, Sundong Kim, Jaehee Kang, Ulhas S. Kadam, Soon Ju Park, Woo Sik Chung, Jong Chan Hong
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Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux J. Adv. Res. (IF 10.7) Pub Date : 2024-01-29 Yuxuan Chen, Junyu Shen, Mengyun Yuan, Huaizhi Li, Yaqi Li, Shanshan Zheng, Bo Han, Cancan Zhang, Shenlin Liu, Qingmin Sun, Jian Wu
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Corrigendum to “New insight into the mechanism by which antifreeze peptides regulate the physiological function of Streptococcus thermophilus subjected to freezing stress” [J. Adv. Res. 45 (2023) 127–140] J. Adv. Res. (IF 10.7) Pub Date : 2024-01-29 Xu Chen, Jinhong Wu, Fujia Yang, Mi Zhou, Ruibin Wang, Jianlian Huang, Yuzhi Rong, Jianhua Liu, Shaoyun Wang
Abstract not available
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Self-assembled co-delivery nanoplatform for increasing the broad-spectrum susceptibility of fall armyworm toward insecticides J. Adv. Res. (IF 10.7) Pub Date : 2024-01-28 Shuo Yan, Mingjian Li, Qinhong Jiang, Mingshan Li, Mengfan Hu, Xueyan Shi, Pei Liang, Meizhen Yin, Xiwu Gao, Jie Shen, Lei Zhang
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Simultaneous binding of quercetin and catechin to FOXO3 enhances IKKα transcription inhibition and suppression of oxidative stress-induced acute alcoholic liver injury in rats J. Adv. Res. (IF 10.7) Pub Date : 2024-01-28 Hui Guan, Wenyuan Zhang, Hui Liu, Yang Jiang, Feng Li, Dan Wang, Yang Liu, Fatao He, Maoyu Wu, Geoffrey Ivan Neil Waterhouse, Dongxiao Sun-Waterhouse, Dapeng Li
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Core fucosylation regulates the ovarian response via FSH receptor during follicular development J. Adv. Res. (IF 10.7) Pub Date : 2024-01-26 Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li
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Inactive-enriched machine-learning models exploiting patent data improve structure-based virtual screening for PDL1 dimerizers J. Adv. Res. (IF 10.7) Pub Date : 2024-01-26 Pablo Gómez-Sacristán, Saw Simeon, Viet-Khoa Tran-Nguyen, Sachin Patil, Pedro J. Ballester
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Specifically targeted antimicrobial peptides synergize with bacterial-entrapping peptide against systemic MRSA infections J. Adv. Res. (IF 10.7) Pub Date : 2024-01-22 Bocheng Xu, Lin Wang, Chen Yang, Rong Yan, Pan Zhang, Mingliang Jin, Huahua Du, Yizhen Wang
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The power and the promise of CAR-mediated cell immunotherapy for clinical application in pancreatic cancer J. Adv. Res. (IF 10.7) Pub Date : 2024-01-18 Hao-Yu Tang, Yi-Zhi Cao, Yi-Wei Zhou, Yu-Shui Ma, Hong Jiang, Hui Zhang, Lin Jiang, Qin-Xin Yang, Xiao-Mei Tang, Chun Yang, Xin-Yun Liu, Fu-Xing Liu, Ji-Bin Liu, Da Fu, Yun-Feng Wang, Hong Yu
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Alanine metabolism mediates energy allocation of the brown planthopper to adapt to resistant rice J. Adv. Res. (IF 10.7) Pub Date : 2024-01-20 Kai Lin, Lei Yue, Longyu Yuan, Kui Kang, Yibing Zhang, Rui Pang, Wenqing Zhang
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The role of endothelial cell–pericyte interactions in vascularization and diseases J. Adv. Res. (IF 10.7) Pub Date : 2024-01-20 Gan Li, Junjie Gao, Peng Ding, Youshui Gao
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Single-cell RNA sequencing combined with proteomics of infected macrophages reveals prothymosin-α as a target for treatment of apical periodontitis J. Adv. Res. (IF 10.7) Pub Date : 2024-01-17 Qimei Gong, Xiaomin Lv, Chenxi Liao, Ailin Liang, Cuiting Luo, Jie Wu, Yanling Zhou, Yihua Huang, Zhongchun Tong
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RvD1 improves resident alveolar macrophage self-renewal via the ALX/MAPK14/S100A8/A9 pathway in acute respiratory distress syndrome J. Adv. Res. (IF 10.7) Pub Date : 2024-01-17 Yang Ye, Qian Yang, Jinling Wei, Chenxi Shen, Haixing Wang, Rong Zhuang, Yuan Cao, Yajun Ding, Haoran Xu, Shuyang Xiang, Hongxia Mei, Zhongwang Li, Xiya Ren, Chen Zhang, Ji Xiao, Shengxing Zheng, Ting Li, Ruifeng Zeng, Huacheng Liu, Han Lin, Qian Wang
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Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer J. Adv. Res. (IF 10.7) Pub Date : 2024-01-17 Jun Liu, Jiaye Lu, Ling Wu, Tingrui Zhang, Junchao Wu, Lisha Li, Zongguang Tai, Zhongjian Chen, Quangang Zhu
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A core-shell AuNRs@BUT-16 nanocomposite for enhancement SERS detection and efficient removal of deoxynivalenol J. Adv. Res. (IF 10.7) Pub Date : 2024-01-17 Jing Tao, Yudan Wang, Wenlei Zhai, Meng Wang
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Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies J. Adv. Res. (IF 10.7) Pub Date : 2024-01-17 Jiayi Li, Changming Guo, Yan Liu, Biqi Han, Zhanjun Lv, Huijie Jiang, Siyu Li, Zhigang Zhang
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Advances focusing on the application of decellularization methods in tendon-bone healing J. Adv. Res. (IF 10.7) Pub Date : 2024-01-17 Sheng Zhong, Yujian Lan, Jinyu Liu, Man Seng Tam, Zhipeng Hou, Qianghua Zheng, Shijie Fu, Dingsu Bao
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The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism J. Adv. Res. (IF 10.7) Pub Date : 2024-01-12 Naibo Feng, Yuanlan Ye, Yiming Pan, Biao Kuang, Yu Du, Nana Geng, Cheng Chen, Kaiwen Liu, Li Liang, Menglin Xian, Yuyou Yang, Xingyue Li, Lin Deng, Fengmei Zhang, Liang Kuang, Mengtian Fan, Yangli Xie, Fengjin Guo
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HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis J. Adv. Res. (IF 10.7) Pub Date : 2024-01-14 Qian Mao, Xiaojin Zhang, Jinna Yang, Qiuyue Kong, Hao Cheng, Wansu Yu, Xiaofei Cao, Yuehua Li, Chuanfu Li, Li Liu, Zhengnian Ding
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Extracellular Derivatives for Bone Metabolism J. Adv. Res. (IF 10.7) Pub Date : 2024-01-11 Yan Wu, Peiran Song, Miaomiao Wang, Han Liu, Yingying Jing, Jiacan Su
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Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds J. Adv. Res. (IF 10.7) Pub Date : 2024-01-11 Xiaoqi Huang, Xingtang Niu, Yuan Ma, Xinhui Wang, Ting Su, Yu He, Feng Lu, Jianhua Gao, Qiang Chang
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Therapeutic effect of phycocyanin on chronic obstructive pulmonary disease in mice J. Adv. Res. (IF 10.7) Pub Date : 2024-01-10 Wenjun Li, Yuanyuan Li, Qi Wang, Runze Liu, Jianing Lu, Wenju Lu, Song Qin
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Diversity of Gibberellin 2-oxidase genes in the barley genome offers opportunities for genetic improvement J. Adv. Res. (IF 10.7) Pub Date : 2024-01-09 Jingye Cheng, Yong Jia, Camilla Hill, Tianhua He, Ke Wang, Ganggang Guo, Sergey Shabala, Meixue Zhou, Yong Han, Chengdao Li
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Multiomics analyses of the effects of LED white light on the ripening of apricot fruits J. Adv. Res. (IF 10.7) Pub Date : 2024-01-09 Chunmei Bai, Yanyan Zheng, Christopher Brian Watkins, Lili Ma, Yuanye Jiang, Shaoqing Chen, Hongwei Wang, Xuelian He, Lichun Han, Xinyuan Zhou, Qing Wang, Caie Wu, Jinhua Zuo
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Current perspectives on microglia-neuron communication in the Central Nervous System: direct and indirect modes of interaction J. Adv. Res. (IF 10.7) Pub Date : 2024-01-07 Yue Hu, Weiwei Tao
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Rare ginsenosides: a unique perspective of ginseng research J. Adv. Res. (IF 10.7) Pub Date : 2024-01-07 Wenxiang Fan, Linhong Fan, Ziying Wang, Yuqi Mei, Longchan Liu, Linnan Li, Li Yang, Zhengtao Wang