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c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis c-Myc-PANK3-EMT axis regulates UC intestinal barrier integrity J. Adv. Res. (IF 13.0) Pub Date : 2025-12-08 Shize Zhang, Yuang Chen, Nan Aa, Chen Xu, Tao Xie, Yi Wang, Tian Cheng, Mengqin Wang, Hong Yu, Xinqiang Ji, Song Zhao, Yaohui Wang, Jun Xiao, Yuan Xie, Guangji Wang, Jiye Aa
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Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation J. Adv. Res. (IF 13.0) Pub Date : 2025-12-07 Haiyan Xiao, Haochen Xie, Meng Qin, Chenwei Zuo, Ruimao Zheng, Shaochan Zhang, Shiyi Sun, Jingxue Ye, Min Wang, Yu Tian, Li Cao, Guibo Sun
Ischemic stroke severely threatens human health. Rapid restoration of cerebral blood flow (CBF) in ischemic microvessels is significant as it enhances neurovascular function, prevents neuronal death, and minimises cerebrovascular injury. Although butylphthalide (NBP) is commonly used to treat ischemic stroke, its exact molecular target remains unclear.
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Aromatic short peptide-metal nanoassemblies in smart hydrogel sensors for real-time food freshness monitoring J. Adv. Res. (IF 13.0) Pub Date : 2025-12-04 Xuecheng Zhu, Jing Su, Yuzhen Wang, Dianwei Zhang, Huilin Liu
The accumulation of volatile biogenic amines (BAs) during food spoilage constitutes a global economic and public health burden. Conventional BA detection methods based on chromatography and electrochemistry are limited by expensive instrumentation and specialized procedures, making on-site monitoring difficult for supply chain personnel and consumers. The lack of portable, user-friendly sensing technologies
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Modulation of the tumor microenvironment through BMAL1-LHX8 axis augments the sensitivity of ameloblastoma to vemurafenib J. Adv. Res. (IF 13.0) Pub Date : 2025-12-03 Shujin Li, Eun-Jung Kim, Hyun-Yi Kim, Takashi Muramatsu, Jun-Young Kim, Jin Hoo Park, Young-Soo Jung, Han-Sung Jung
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Unique molecular architecture of N-glycosylated TM4SF5 dimer highlights evolutionary and structural divergence among small four-transmembrane protein families J. Adv. Res. (IF 13.0) Pub Date : 2025-12-03 Yoonji Lee, Ji Eon Kim, Wonsik Kim, Soyeon Kim, Ri Han, Donghyuk Suh, Eunmi Kim, Eun-Ae Shin, Kyung-hee Pyo, Jae-Ho Lee, Sanghee Yoon, Yong-In Kim, Je-Yoel Cho, Sun Choi, Jung Weon Lee
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Intratumoral microbiota in colorectal cancer: roles, therapeutic potential, and challenges J. Adv. Res. (IF 13.0) Pub Date : 2025-12-01 Xiyu Zhang, Junwen Qi, Chenhua Dong, Long Zhang, Junnan Chen, Jianquan Liu, Tao Jiang, Jun Song
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Pericyte-myofibroblast transition: a novel mechanism in peritoneal fibrosis and the effect of Asiaticoside J. Adv. Res. (IF 13.0) Pub Date : 2025-12-01 Jun Shi, Lei Tang, Manshu Yu, Yun Shan, Xiaolin Zhu, Yawei Zheng, Meixiao Sheng
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From waste to resource: development of selenium-enhanced iron-carbon galvanic materials from landfill leachate for efficient mercury and thallium detoxification in contaminated waters J. Adv. Res. (IF 13.0) Pub Date : 2025-12-01 Dongping Song, Tao Huang, Jialin Cui, Kai Chen, Xiaolong Sun, Yun Xia, Chong Luo, Weihua Liu, Yang Zhang, Chengzhe Yang
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Identification of marginal zone B cells in head and neck cancer with immunomodulatory characteristics J. Adv. Res. (IF 13.0) Pub Date : 2025-11-29 Jiantong Bao, Jochen Hess, Annika C. Betzler, Zhen Zhang, Miltiadis Tsesmelis, Sebastian Schmid, Gaurav Berry, Patrick J. Schuler, Jens Greve, Simon Laban, Thomas K. Hoffmann, Medhanie Mulaw, Cornelia Brunner
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Paracrine iron activates Hopx+ rectal cancer stem cells to display radioresistance J. Adv. Res. (IF 13.0) Pub Date : 2025-11-29 Xiangjun Liu, Xudan Lei, Jianhua Feng, Lu Xu, Yajun Luo, Xi Wang, Nan Wang, Yujun Huang, Yikun Luo, Hefei Tian, Banghui Liu, Shubin Wang, Lingxiao Huang, Zhenni Xu, Hai Hu, Chao Liu, Jinyi Lang, Dengqun Liu
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Integrative computational-experimental discovery of α-hederin as a multi-mechanistic, low-toxicity antifungal agent targeting Candida albicans CYP51 J. Adv. Res. (IF 13.0) Pub Date : 2025-11-29 Xuan Wang, Yuchun Zhang, Gansukh Sunderiya, Zhipeng Xin, Yulan Ji, Saixue Yang, Di Han, Xianqing Chen, Dongyan Shao, Junling Shi, Chunmei Jiang
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BMP4 cocktail promotes utricular progenitor reprogramming and vestibular functional recovery in adult mice J. Adv. Res. (IF 13.0) Pub Date : 2025-11-29 Dan You, Yunzhong Zhang, Kunkun Wang, Luo Guo, Jin Guo, Chenhao Che, Wen Li, Liping Zhao, Huawei Li, Shan Sun
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Macrophage-induced immunomodulation in oral tissue repair and regeneration: Recent advances and future perspectives J. Adv. Res. (IF 13.0) Pub Date : 2025-11-29 Yujie Wang, Jing Mao, Yifan Wang, Rui Wang, Dajie Duan, Zhenyuan Liu, Xiaohan Hu, Zili Yu, Xin Shi
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A novel link between enhanced chenodeoxycholic acid synthesis and multi-walled carbon nanotubes-induced proliferation inhibition and apoptosis in human ocular cells J. Adv. Res. (IF 13.0) Pub Date : 2025-11-29 Yunxia Liang, Yang Zhou, Dongli Xie, Ya Wang, Yuexiao Sun, Xiaogang Luo
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Arachidonic acid metabolism in spinal cord injury J. Adv. Res. (IF 13.0) Pub Date : 2025-11-28 Xue Yao, Xinjie Liu, Wenbin Cai, Guangzhi Ning, Xu Zhang, Kailiang Zhou, Shiqing Feng
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Development and validation of an interpretable machine learning model using routine laboratory biomarkers to stratify severe pneumonia risk in young children J. Adv. Res. (IF 13.0) Pub Date : 2025-11-27 Wei Cui, Xinlv Zhang, Yang Chen, Diwon Anthony, Guomiao Zhang, Qichao Sheng, Huiqin Mei, Mengtin Yin, Yan Fang, Qingyang Mao, Dapeng Li, Guangyun Mao, Haipeng Liu
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Retraction notice to “Estrogen prevent atherosclerosis by attenuating endothelial cell pyroptosis via activation of estrogen receptor α-mediated autophagy.” [J. Adv. Res. 28 (2021) 149–164] J. Adv. Res. (IF 13.0) Pub Date : 2025-11-27 Qinghai Meng, Yu Li, Tingting Ji, Ying Chao, Jun Li, Yu Fu, Suyun Wang, Qi Chen, Wen Chen, Fuhua Huang, Youran Wang, Qichun Zhang, Xiaoliang Wang, Huimin Bian
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal).
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Selenoprotein H targets MTCH2 to regulate MFN2-dependent mitochondrial quality control to alleviate acute kidney injury J. Adv. Res. (IF 13.0) Pub Date : 2025-11-26 Dongliu Luo, Yaning Qiu, Jiahong Chu, Haodong Hu, Yanhe Zhang, Yu Xia, Fuze She, Shiwen Xu, Fating Zhu, Zhiruo Miao, Shu Li
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Transforming destructive mechanical cues into therapeutic power: Activation of PIEZO1 and TRPV4 counteracts mechano-induced damage of cellular junctions in Hailey-Hailey disease J. Adv. Res. (IF 13.0) Pub Date : 2025-11-26 Jiahui Hu, Yuanbo Jia, Fan Feng, Qiang Zhao, Bin Peng, Xi Wang, Huayi Xiong, Feng Xu, Songmei Geng
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Urinary Cell-Free DNA detection platform for bacterial cystitis diagnosis via spot-based machine learning J. Adv. Res. (IF 13.0) Pub Date : 2025-11-26 Yan Liu, Kai Xiao, Ziping Wu, Qiang Wu, Xiaochun Xie, Minghao He, Hui Zhang, Lei Cao, Baiyang Bao, Weihang Guo, Fangman Chen, Ren Mo, Kewei Ma, Dan Shao
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Novel protein acylations in Alzheimer’s disease: Molecular, mechanisms, biological significance, and diagnostic and therapeutic potentials J. Adv. Res. (IF 13.0) Pub Date : 2025-11-25 Yue Yang, Zhihua Yu, Rui Gao, Yuehua Zhang, Ziyi Zhang, Xin Zhong, Linchi Jiao, Ke Du, Yuqiang Wu, Minjie Wei, Mingyan Liu
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Rhein alleviates acute pancreatitis by inhibiting TMAO-mediated inflammatory signaling pathways and reducing acinar cell injury J. Adv. Res. (IF 13.0) Pub Date : 2025-11-25 Yunshu Zhang, Jifeng Liu, Xiaonan Zhang, Shan Cheng, Shuyuan Liu, Anliang Huang, Yanlong Yu, Jianjun Liu, Hailong Chen, Dong Shang, Peiyuan Yin, Shurong Ma
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Spop-binding bifunctional degraders: a novel approach for cancer immunotherapy J. Adv. Res. (IF 13.0) Pub Date : 2025-11-25 Binbin Cheng, Zhihua Kong, Yaru Shi, Yinrong Wu, Jing-Jing Du, Shuanghu Wang, Jianjun Chen, Congcong Wen
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A lightweight fully convolutional neural network for efficient and accurate tunnel crack detection J. Adv. Res. (IF 13.0) Pub Date : 2025-11-24 Hao Huang, G.T.S. Ho, V. Tang, E.W.H. Chow, W.H. Ip, K.L. Yung
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The landscape of genitourinary cancer vaccines: clinical advances and future opportunities J. Adv. Res. (IF 13.0) Pub Date : 2025-11-24 Ruoxuan Zheng, Yuxin Cai, Weihong Ding, Feng Yang, Xu Ke, Yuan Gao
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Burden profiles and mortality-attributable risk factors for gastrointestinal cancers: A comprehensive analysis, 1990–2021 J. Adv. Res. (IF 13.0) Pub Date : 2025-11-24 Ahui Fan, Chunbaixue Yang, Yangyan Fan, Lianlian Tian, Zhiping Yang, Daiming Fan
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Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss J. Adv. Res. (IF 13.0) Pub Date : 2025-11-24 Xi Chen, MengXue Zhang, Lihui Qian, Yang Guo, Yihua Zhu, Wumiti Taxi, Mengmin Liu, Kaixuan Wang, Likun Song, Chunlei Zhang, Yafeng Zhang, Lining Wang, Yong Ma, Yue Hu
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Eravacycline and omadacycline Rescue multidrug-resistant Elizabethkingia anophelis: Triple-Model evaluation across in Vitro, Galleria mellonella, and murine bacteremia systems J. Adv. Res. (IF 13.0) Pub Date : 2025-11-24 Shaohua Hu, Li Jiang, Hao Xu, Xiaohua Meng, Duo Zhang, Di Zhou, Yonghong Xiao, Beiwen Zheng
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Cinnamic acid derivatives in agrochemicals: current use and future perspective J. Adv. Res. (IF 13.0) Pub Date : 2025-11-24 Qiong Lei, Wei Zhang, Wang Geng, Zhichao Jin, Xiuhai Gan
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A rapidly fabricated bone marrow enrichment material with a controllable pore size promotes osteogenesis close to autogenous bone graft in clinic J. Adv. Res. (IF 13.0) Pub Date : 2025-11-24 Qiandong Yang, Bo Yu, Chunyu Liu, Jiangling Zhou, Yang Zhang, Ming Yang, Sihao He, Juan Cai, Qijie Dai, Zhenzhen Tang, Jianzhong Xu, Zhongrong Zhang, Tianyong Hou
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Deciphering the genetic basis of nodule number through integrative analysis of host genotype and endophytes J. Adv. Res. (IF 13.0) Pub Date : 2025-11-23 Ruier Zeng, Peiqi Huang, Yunyi Guo, Xiang Zhang, Weicheng Yu, Qinghui Geng, Xi Li, Jiangtao Tan, Qingqing Pan, Yong Chen, Tingting Chen, Lei Zhang
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Vessels encapsulating tumor clusters is associated with impaired efficacy of adjuvant immunotherapy in resected hepatocellular carcinoma J. Adv. Res. (IF 13.0) Pub Date : 2025-11-23 Bin Guo, Guangzhen Cai, Jinghan Zhu, Qian Chen, Danfeng Li, Hao Zhang, Zhicheng Liu, Nin Cai, Yang Wu, Dong Kuang, Xuguang Liu, Yuanxiang Lu, Changzhen Shang, Xiaoping Chen, Hui Zhang, Hong Zhu, Wanguang Zhang
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Generation of antifungals to combat drug resistance using language models and diffusion models J. Adv. Res. (IF 13.0) Pub Date : 2025-11-22 Yeji Wang, Yuemei Dong, Yi Zheng, Lintao Xu, Minghui Song, Jiahui Chen, Kunkun Zhang, Tao Shen, Wei Zhao, Hongxiang Lou, Wenqiang Chang
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Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study J. Adv. Res. (IF 13.0) Pub Date : 2025-11-22 Yanwei You, Jinwei Li, Yang Zhang, Qiyu Liu, Alimjan Ablitip, Yongjie Lao, Jingtong Wang, Kailin Xu, Zhengbang Yao, Yuquan Chen, Xindong Ma
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Tripterygium wilfordii multi-glycoside alleviates ankylosing spondylitis via gut microbiota modulation and metabolite reprogramming J. Adv. Res. (IF 13.0) Pub Date : 2025-11-22 Jiaqi Bi, Yanan Yang, Mingxi Li, Huigen Lu, Bin Chen, Xuekang Pan, Gang Chen, Chongming Wu
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ANXA1 improves mitochondrial homeostasis through uncoupling protein 1 in diabetic nephropathy J. Adv. Res. (IF 13.0) Pub Date : 2025-11-22 Zi-Han Li, Lu Fang, Liang Wu, Dong-Yuan Chang, Manyuan Dong, Liang Ji, Qi Zhang, Ming-Hui Zhao, Sydney C.W. Tang, Lemin Zheng, Min Chen
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Identification and evaluation of a lipid-lowering small compound as a PCSK9 inhibitor J. Adv. Res. (IF 13.0) Pub Date : 2025-11-21 Run Xu, Xutong Wang, Jin Gao, Yiyang Li, Song Wang, Huimin Li, Bin Sun, Zijia Dou, Yingying Hu, Tong Zhao, Heng Liu, Jennifer Wang, Yu Liu, Xiaodong Fang, Meng Sun, Yong Zhang, Weina Han, Xin Liu
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Dietary patterns and testosterone balance: a review of clinical data and perspectives J. Adv. Res. (IF 13.0) Pub Date : 2025-11-20 Xinyi Liu, Xusheng Li, Dongbao Cai, Jianxia Sun, Weibin Bai
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Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associated cardiac hypertrophy J. Adv. Res. (IF 13.0) Pub Date : 2025-11-20 Gahee Song, Se Jin Jung, Wenjun Jiao, Woo Yong Park, Yunju Jo, Ja Yeon Park, Seong-Kyu Choe, In Jin Ha, Peter K. Kim, Dongryeol Ryu, Kuk Hui Son, Hyun Jeong Kwak, Jae-Young Um
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From theory to practice: DFT-guided Raman spectral analysis and machine learning for high-accuracy pesticide identification J. Adv. Res. (IF 13.0) Pub Date : 2025-11-20 Yingcheng Xing, Yuan Gao, De Zhang, Jie Huang, Qianmin Dong, Qiao Tang, Yufeng Wang, Zihong Ye, Pei Liang
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Dual rescue mission: P-G3 dendrimer addresses ovarian and neuroendocrine roots of obesity-linked subfertility J. Adv. Res. (IF 13.0) Pub Date : 2025-11-20 Yunhan Nie, Zhe Kuang, Jiqiang Si, Yuting Huang, Yuqi Zeng, Xi Shen, Yali Liu, Lin Qiu, Li Wang
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Carbon–phosphorus coupling in reddish paddy fields under long-term organic material input: Temporal dynamics and the role of pqqC-harboring bacteria as a driver J. Adv. Res. (IF 13.0) Pub Date : 2025-11-20 Jian Xiao, Yanhong Lu, Peng Li, Yu Wang, Jianglin Zhang, Yulin Liao, Jun Nie
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Metagenomic characterization of the resistome, bacteriome and mobilome in raw milk from intensive farming systems J. Adv. Res. (IF 13.0) Pub Date : 2025-11-19 Yiping Xu, Jie Zhao, Ningxin Huang, Zhengxiao Wang, Lu Liu, Yue Wang, Quanying Qu, Qi Li, Qingli Yang, Guoliang Wang, Guiming Liu, Qinzhi Wang, Wei Wu
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Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD J. Adv. Res. (IF 13.0) Pub Date : 2025-11-19 Li Liu, Suye Zhong, Tengfei Zhou, Yixing Wu, Weiping Hu, Xiao Wang, Yue Ren, Kankai Wang, Xinhua Lin, Jing Zhang
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Reactions of N-heterocyclic carbenes with nitrobenzenes: harnessing NHCs as synthetic building blocks J. Adv. Res. (IF 13.0) Pub Date : 2025-11-19 Zhiguo Zheng, Youlin Deng, Xiaoqun Yang, Zhichao Jin, Shiqing Huang, Jian Wu, Yonggui Robin Chi
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Non-traditional lipid-inflammatory parameters estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study J. Adv. Res. (IF 13.0) Pub Date : 2025-11-17 Xiaxuan Huang, Cun Li, Piaorong Zeng, Yitong Ling, Shanyuan Tan, Zihong Bai, Si Shen, Shengting Chen, Biao Nie, Hao Wang, Jun Lyu
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Embryo vitrification disturbs the pre-implantation DNA demethylation process and affects hepatic functions to threaten long-term metabolic health in mice J. Adv. Res. (IF 13.0) Pub Date : 2025-11-17 Yue Ying, Yang Yang, Xilin Shen, Yuli Qian, Jianpeng Chen, Yanyun Ying, Hao Jin, Yazeed Allan, Yifeng Lin, Feixia Wang, Juan Liu, Junyan Zheng, Jiani Jin, Yifeng Liu, Qingyuan Sun, Hongqing Liang, Weimin Ci, Dan Zhang, Chuan Chen
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Lactoferrin alleviates non-alcoholic steatohepatitis via remodeling gut microbiota to regulate serotonin-related pathways J. Adv. Res. (IF 13.0) Pub Date : 2025-11-16 Li Ding, Jia-Ying Xu, Li-Li Zhang, Yan Liu, Kai-Tian Gu, Yan-Zi Liang, Khemayanto Hidayat, Zhongxiao Wan, Guo-Chong Chen, Li-Qiang Qin
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ZUP1 promotes DNA repair and immune evasion to drive olaparib resistance in triple-negative breast cancer J. Adv. Res. (IF 13.0) Pub Date : 2025-11-16 Shanshan Huang, Yu Qiu, Linyu Wu, Yi Xie, Zhiting He, Yingqing Li, Xinhua Xie
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IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway J. Adv. Res. (IF 13.0) Pub Date : 2025-11-16 Menglong Hu, Erfan Wei, Likun Wu, Xingtong Pan, Qiyue Zhu, Xiuyun Xv, Xinyi Dong, Weiliang Wu, Hao Liu, Yunsong Liu
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Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway J. Adv. Res. (IF 13.0) Pub Date : 2025-11-16 Zihan Wang, Le Luo Guan, Jianping Wu
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Impacts of trichothecene mycotoxins on human colonic epithelial cells: molecular mechanisms and signaling pathways J. Adv. Res. (IF 13.0) Pub Date : 2025-11-16 Shao-Ji Li, Chun-Min Yang, Shiyi Ou
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Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal J. Adv. Res. (IF 13.0) Pub Date : 2025-11-16 Xiaojiao Li, Xiangchuan Qin, Xiejun Zhao, Yufeng Liu, Ling Wang, Kefeng Li, Jinqiu Li, Jia Ma, Liangliang Dai, Ayshamgul Hasim
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Gestational exposure to PM2.5 impaired cardiac development through ANGPTL4-mediated mitochondrial metabolic dysfunction J. Adv. Res. (IF 13.0) Pub Date : 2025-11-15 Jianong Lv, Ruiyang Ding, Chen Liang, Li Tian, Zhiru Liu, Shiqian Liu, Zhiqin Xiong, Ruixia Liu, Zhiwei Sun, Chenghong Yin, Junchao Duan
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Single-nucleus RNA sequencing illuminates a functional analog of lymphoid organ in crustacean J. Adv. Res. (IF 13.0) Pub Date : 2025-11-15 Mingzhe Sun, Shihao Li, Yuan Liu, Fuhua Li
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Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue J. Adv. Res. (IF 13.0) Pub Date : 2025-11-15 Wenjiao Jiang, Sasa Zhang, Xinyuan Sun, Shun Wang, Jinwei Zhu, Ziao Liu, Wanting Zhang, Huijie Guo, Hanwen Li, Hao Xie, Kun Hao
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Graphene mesosponge: a novel material for the sequestration of azo dyes in water J. Adv. Res. (IF 13.0) Pub Date : 2025-11-14 Amrita Jain, Chandini Kumar, Peter Škorňa, Hirotaka Nakatsuji, Hirotomo Nishihara, Tamas Szabo, Olena Ivashchenko, Monika Michalska, Eva Scholtzova
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SIRT3-activating, biodegradable poly-honokiol with high drug loading for thoracic aortic dissection therapy J. Adv. Res. (IF 13.0) Pub Date : 2025-11-14 Xi’nan Qiao, Daquan Wang, Hanzhao Zhu, Bin Zhang, He Sun, Jiali Wang, Gang Tan, Liqing Jiang, Xiangyan Peng, Liyun Zhang, Longteng Wang, Siyu Han, Lingjie Meng, Weixun Duan
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The OsLHY-OsSCL30/OsDHT1 regulatory cascade coordinates heading date and plant height through Pre-mRNA splicing modulation in rice J. Adv. Res. (IF 13.0) Pub Date : 2025-11-14 Yingying Lu, Yixian Guo, Rui Gao, Jinying Li, Chong Yang, Wenjian Song, Dianxing Wu, Jean Wan Hong Yong, Lujun Yu, Xiaoli Jin
更新日期：2025-12-04
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