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The argument framework is a flexible approach to evidence in healthcare Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Jonathan Fuller, Benjamin Chin-Yee, Ross E. G. Upshur
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Bispecific T cell engager therapy for refractory rheumatoid arthritis Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Laura Bucci, Melanie Hagen, Tobias Rothe, Maria Gabriella Raimondo, Filippo Fagni, Carlo Tur, Andreas Wirsching, Jochen Wacker, Artur Wilhelm, Jean-Philippe Auger, Milena Pachowsky, Markus Eckstein, Stefano Alivernini, Angelo Zoli, Gerhard Krönke, Stefan Uderhardt, Aline Bozec, Maria-Antonietta D’Agostino, Georg Schett, Ricardo Grieshaber-Bouyer
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Reproductive rights in the United States: acquiescence is not a strategy Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Laura J. Esserman, Douglas Yee
Scientific and medical conferences should not be held in states that ban abortion, as such bans put the lives of women at risk.
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Large language models for preventing medication direction errors in online pharmacies Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Cristobal Pais, Jianfeng Liu, Robert Voigt, Vin Gupta, Elizabeth Wade, Mohsen Bayati
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Urgent action is needed to confront artemisinin partial resistance in African malaria parasites Nat. Med. (IF 82.9) Pub Date : 2024-04-25
Discover the world’s best science and medicine | Nature.com
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New risk score for cardiovascular disease with improved performance Nat. Med. (IF 82.9) Pub Date : 2024-04-23
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Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses Nat. Med. (IF 82.9) Pub Date : 2024-04-23 Claire F. Friedman, Beryl L. Manning-Geist, Qin Zhou, Tara Soumerai, Aliya Holland, Arnaud Da Cruz Paula, Hunter Green, Melih Arda Ozsoy, Alexia Iasonos, Travis Hollmann, Mario M. Leitao, Jennifer J. Mueller, Vicky Makker, William P. Tew, Roisin E. O’Cearbhaill, Ying L. Liu, Maria M. Rubinstein, Tiffany Troso-Sandoval, Stuart M. Lichtman, Alison Schram, Chrisann Kyi, Rachel N. Grisham, Pamela Causa
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The hype and hope of new food allergy treatments Nat. Med. (IF 82.9) Pub Date : 2024-04-22 Kirsten P. Perrett
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Strategies for controlling pneumococcal disease and outbreaks during humanitarian emergencies Nat. Med. (IF 82.9) Pub Date : 2024-04-22 Molly Cliff, Paul Welaga, Nuredin Mohammed, Patrick Ansah, Robert S. Heyderman, Caroline Trotter, Brenda Kwambana-Adams
Streptococcus pneumoniae infection accounts for nearly one-fifth of all meningitis deaths globally, half of which occur in Sub-Saharan Africa. Pneumococcal conjugate vaccines (PCVs) prevent vaccine-serotype disease and have been rolled out as part of infant immunization programs worldwide1. Despite widespread PCV usage, the burden of pneumococcal meningitis remains highest within the so called ‘African
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mRNA therapy for a rare childhood disease Nat. Med. (IF 82.9) Pub Date : 2024-04-22
An mRNA-based drug aims to replace a faulty enzyme and restore metabolic function in children with propionic acidemia — with encouraging early clinical results.
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Repurposing a diabetes drug to treat Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-20
In a multicenter clinical trial, patients with early-stage Parkinson’s disease treated with lixisenatide, a drug currently used for the treatment of diabetes, showed improvement in their motor scores compared with those on placebo.
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Using unlabeled data to enhance fairness of medical AI Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Rajiv Movva, Pang Wei Koh, Emma Pierson
AI models for tasks such as pathology and dermatology struggle to generalize to new patient groups or hospitals that they were not trained on; learning more robust features from unlabeled data could prevent overfitting to the training distribution and thereby increase fairness.
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Microplastics are everywhere — we need to understand how they affect human health Nat. Med. (IF 82.9) Pub Date : 2024-04-19
As evidence emerges describing the accumulation of small plastic particles in various organs and tissues of the body, a much deeper understanding of the effects of these particles on human health is urgently needed.
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Demographic bias in misdiagnosis by computational pathology models Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Anurag Vaidya, Richard J. Chen, Drew F. K. Williamson, Andrew H. Song, Guillaume Jaume, Yuzhe Yang, Thomas Hartvigsen, Emma C. Dyer, Ming Y. Lu, Jana Lipkova, Muhammad Shaban, Tiffany Y. Chen, Faisal Mahmood
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Risk-based lung cancer screening performance in a universal healthcare setting Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Martin C. Tammemägi, Gail E. Darling, Heidi Schmidt, Meghan J. Walker, Deanna Langer, Yvonne W. Leung, Kathy Nguyen, Beth Miller, Diego Llovet, William K. Evans, Daniel N. Buchanan, Gabriela Espino-Hernandez, Usman Aslam, Amanda Sheppard, Aisha Lofters, Micheal McInnis, Julian Dobranowski, Steven Habbous, Christian Finley, Marianne Luettschwager, Erin Cameron, Caroline Bravo, Anna Banaszewska, Katherin
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Climate change and health: understanding mechanisms will inform mitigation and prevention strategies Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Diddier Prada, Andrea A. Baccarelli, Allison Kupsco, Robbie M. Parks
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Post-election responsibilities for public health in the Democratic Republic of the Congo Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Faraan O. Rahim, William C. Lieber, Julian T. Hertz, Bruce Shinga Wembulua, Patrick A. Ndeba, Richard M. Lukelwa
Since gaining independence in 1960, the Democratic Republic of the Congo (DRC) has faced a complicated series of challenges marked by armed conflict, political instability and economic hardships. Tensions in the DRC are on an escalating trajectory as the Congolese army and its allied militias battle with the March 23 Movement group in North and South Kivu. Attempts to restore peace through the Nairobi
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Opportunities and challenges following approval of resmetirom for MASH liver disease Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Jeffrey V. Lazarus, Dana Ivancovsky Wajcman, Henry E. Mark, Zobair M. Younossi, Christopher J. Kopka, Nevin Cohen, Meena B. Bansal, Michael Betel, Paul N. Brennan
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An autoantibody signature predictive for multiple sclerosis Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Colin R. Zamecnik, Gavin M. Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D. Bair, Kristen J. Wade, Christopher M. Bartley, Kerry Kizer, Danillo G. Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M. Caspar, Jessica Alexander, Anne E. Wapniarski, Rita P. Loudermilk, Erica L. Eggers, Kelsey C. Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A. Mann, Nicholas R. Ragan,
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Causal machine learning for predicting treatment outcomes Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Stefan Feuerriegel, Dennis Frauen, Valentyn Melnychuk, Jonas Schweisthal, Konstantin Hess, Alicia Curth, Stefan Bauer, Niki Kilbertus, Isaac S. Kohane, Mihaela van der Schaar
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Development and validation of a new algorithm for improved cardiovascular risk prediction Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Julia Hippisley-Cox, Carol A. C. Coupland, Mona Bafadhel, Richard E. K. Russell, Aziz Sheikh, Peter Brindle, Keith M. Channon
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Targeting KRAS in cancer Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Anupriya Singhal, Bob T. Li, Eileen M. O’Reilly
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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Amit Saraf, Rohan Gurjar, Swarnendu Kaviraj, Aishwarya Kulkarni, Durgesh Kumar, Ruta Kulkarni, Rashmi Virkar, Jayashri Krishnan, Anjali Yadav, Ekta Baranwal, Ajay Singh, Arjun Raghuwanshi, Praveen Agarwal, Laxman Savergave, Sanjay Singh
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy Nat. Med. (IF 82.9) Pub Date : 2024-04-17 Ryan M. Jamiolkowski, Quynh-Anh Nguyen, Jordan S. Farrell, Ryan J. McGinn, David A. Hartmann, Jeff J. Nirschl, Mateo I. Sanchez, Vivek P. Buch, Ivan Soltesz
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Nicotine e-cigarettes: considerations for healthcare providers Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Benjamin A. Toll, Tracy T. Smith, Brian A. King
Tobacco use continues to be the leading cause of preventable disease and death in the United States. There are no safe tobacco products; however, the health risks for tobacco products exist on a continuum, with combustible products such as cigarettes being the most harmful. Decades of research have documented that cigarette smoking harms nearly every organ of the body; cigarette smoke contains nearly
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A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Norah L. Crossnohere, Nicola Anderson, Judith Baumhauer, Melanie Calvert, Rebecca Esparza, Sandi Gulbransen, Lotte Haverman, Yuchen Li, Carolyn Petersen, Ameeta Retzer, Christopher Sidey-Gibbons, Angela M. Stover, Elissa Thorner, Garrett Ursin, Galina Velikova, Elliott Sparkman Walker, Michael Brundage, Claire Snyder
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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe
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Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Fei Tian, Dong Liu, Na Wei, Qianqian Fu, Lin Sun, Wei Liu, Xiaolong Sui, Kathryn Tian, Genevieve Nemeth, Jingyu Feng, Jingjing Xu, Lin Xiao, Junya Han, Jingjie Fu, Yinhua Shi, Yichen Yang, Jia Liu, Chunhong Hu, Bin Feng, Yan Sun, Yunjun Wang, Guohua Yu, Dalu Kong, Meiyun Wang, Wencai Li, Kexin Chen, Xiangchun Li
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Transparent medical image AI via an image–text foundation model grounded in medical literature Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Chanwoo Kim, Soham U. Gadgil, Alex J. DeGrave, Jesutofunmi A. Omiye, Zhuo Ran Cai, Roxana Daneshjou, Su-In Lee
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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-15 Gennaro Pagano, Kirsten I. Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek, Ronald B. Postuma, Nicola Pavese, Fabrizio Stocchi, Kathrin Brockmann, Hanno Svoboda, Dylan Trundell, Annabelle Monnet, Rachelle Doody, Paulo Fontoura, Geoffrey A. Kerchner, Patrik Brundin, Tania Nikolcheva, Azad Bonni
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Designer antibiotics by generative AI Nat. Med. (IF 82.9) Pub Date : 2024-04-12
Researchers developed an AI model that designs novel, synthesizable antibiotic compounds — several of which showed potent in vitro activity against priority pathogens.
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Why diversity is needed at every level of clinical trials, from participants to leaders Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Khadijah Breathett
Diversity in clinical trials must be accompanied by justice and equity, including benefits for underrepresented participants, in order to boost population health.
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Functional precision medicine for pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 M. Emmy M. Dolman, Paul G. Ekert
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Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Arlet M. Acanda De La Rocha, Noah E. Berlow, Maggie Fader, Ebony R. Coats, Cima Saghira, Paula S. Espinal, Jeanette Galano, Ziad Khatib, Haneen Abdella, Ossama M. Maher, Yana Vorontsova, Cristina M. Andrade-Feraud, Aimee Daccache, Alexa Jacome, Victoria Reis, Baylee Holcomb, Yasmin Ghurani, Lilliam Rimblas, Tomás R. Guilarte, Nan Hu, Daria Salyakina, Diana J. Azzam
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Generative models improve fairness of medical classifiers under distribution shifts Nat. Med. (IF 82.9) Pub Date : 2024-04-10 Ira Ktena, Olivia Wiles, Isabela Albuquerque, Sylvestre-Alvise Rebuffi, Ryutaro Tanno, Abhijit Guha Roy, Shekoofeh Azizi, Danielle Belgrave, Pushmeet Kohli, Taylan Cemgil, Alan Karthikesalingam, Sven Gowal
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‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease Nat. Med. (IF 82.9) Pub Date : 2024-04-10
Nature Medicine explores the latest translational and clinical research news, with clinical trials testing glycosylated autoantigens as immunotolerance therapies.
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Tackling heat-related mortality in aging populations Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Josiah L. Kephart, Safiyyah M. Okoye
A large study of older adults in China points to physical and cognitive function — not age — as key predictors of heat-related mortality, highlighting the need for climate adaptation policies to prioritize accessibility across all age groups.
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Food is medicine: clinical trials show the health benefits of dietary interventions Nat. Med. (IF 82.9) Pub Date : 2024-04-08
Growing evidence shows that dietary interventions can be effective at treating or delaying some diseases, but further trials are needed for wider adoption.
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Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Carolyn
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Continuous glucose monitoring and intrapersonal variability in fasting glucose Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Smadar Shilo, Ayya Keshet, Hagai Rossman, Anastasia Godneva, Yeela Talmor-Barkan, Yaron Aviv, Eran Segal
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Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial Nat. Med. (IF 82.9) Pub Date : 2024-04-07 Mark Yarchoan, Edward J. Gane, Thomas U. Marron, Renzo Perales-Linares, Jian Yan, Neil Cooch, Daniel H. Shu, Elana J. Fertig, Luciane T. Kagohara, Gabor Bartha, Josette Northcott, John Lyle, Sarah Rochestie, Joann Peters, Jason T. Connor, Elizabeth M. Jaffee, Ildiko Csiki, David B. Weiner, Alfredo Perales-Puchalt, Niranjan Y. Sardesai
Programmed cell death protein 1 (PD-1) inhibitors have modest efficacy as a monotherapy in hepatocellular carcinoma (HCC). A personalized therapeutic cancer vaccine (PTCV) may enhance responses to PD-1 inhibitors through the induction of tumor-specific immunity. We present results from a single-arm, open-label, phase 1/2 study of a DNA plasmid PTCV (GNOS-PV02) encoding up to 40 neoantigens coadministered
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Elevating kidney disease on the global health stage Nat. Med. (IF 82.9) Pub Date : 2024-04-04
Global nephrology societies have called on the WHO and health communities to tackle the growing burden of chronic kidney disease, which has been under-recognized for too long.
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Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas Nat. Med. (IF 82.9) Pub Date : 2024-04-03 Leandro. C Cerchietti, Eloisi. C Lopes, Shao. Ning Yang, Katerina Hatzi, Karen. L Bunting, Lucas. A Tsikitas, Alka Mallik, Ana. I Robles, Jennifer Walling, Lyuba Varticovski, Rita Shaknovich, Kapil. N Bhalla, Gabriela Chiosis, Ari Melnick
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Systematic testing in cholera surveillance enhances vaccine impact and cost-effectiveness Nat. Med. (IF 82.9) Pub Date : 2024-04-03
Most suspected cholera cases are not tested for Vibrio cholerae. Integrating systematic testing into cholera surveillance systems, even with imperfect rapid diagnostic tests, could yield large gains in efficiency and cost savings in the geographic targeting of mass oral cholera vaccination campaigns.
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Large language models for reducing clinicians’ documentation burden Nat. Med. (IF 82.9) Pub Date : 2024-04-01 Kirk Roberts
Evaluation of a clinical summarization method based on GPT-4 suggests that such models might reduce the documentation burden on clinicians — but prospective evaluation with high-priority tasks will be the true test of its potential.
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Going the extra mile to increase vaccine uptake Nat. Med. (IF 82.9) Pub Date : 2024-03-28
Deployment of mobile vaccination teams to remote communities in Sierra Leone substantially increased COVID-19 vaccine uptake, and could potentially be bundled with other health interventions.
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Microplastics at heart of the problem Nat. Med. (IF 82.9) Pub Date : 2024-03-27
Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiovascular events and mortality than those in whom the particles were not detected.
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A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-03-27 Amy R. Rappaport, Chrisann Kyi, Monica Lane, Meghan G. Hart, Melissa L. Johnson, Brian S. Henick, Chih-Yi Liao, Amit Mahipal, Ardaman Shergill, Alexander I. Spira, Jonathan W. Goldman, Ciaran D. Scallan, Desiree Schenk, Christine D. Palmer, Matthew J. Davis, Sonia Kounlavouth, Lindsey Kemp, Aaron Yang, Yaojun John Li, Molly Likes, Annie Shen, Gregory R. Boucher, Milana Egorova, Robert L. Veres, J.
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Combination treatment for immune-mediated HIV remission Nat. Med. (IF 82.9) Pub Date : 2024-03-26
In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of viremia after discontinuation of antiretroviral therapy.
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Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease Nat. Med. (IF 82.9) Pub Date : 2024-03-26 Anubha Agarwal, Priya M. Mehta, Tyler Jacobson, Nilay S. Shah, Jiancheng Ye, JingJing Zhu, Q. Eileen Wafford, Ehete Bahiru, Angharad N. de Cates, Shah Ebrahim, Dorairaj Prabhakaran, Anthony Rodgers, Mark D. Huffman
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Risk factors associated with heatwave mortality in Chinese adults over 65 years Nat. Med. (IF 82.9) Pub Date : 2024-03-25 Di Xi, Linxin Liu, Min Zhang, Cunrui Huang, Katrin G. Burkart, Kristie Ebi, Yi Zeng, John S. Ji
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Promoting gender equity in the scientific and health workforce is essential to improve women’s health Nat. Med. (IF 82.9) Pub Date : 2024-03-22 Cristiani Vieira Machado, Cristina Araripe Ferreira, Maria Auxiliadora de Souza Mendes Gomes
Women’s health can be improved by increasing the representation of women in leadership roles in science, medicine and public health.
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Testing pooled samples enables universal screening of congenital cytomegalovirus infection Nat. Med. (IF 82.9) Pub Date : 2024-03-21
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Off-label use of artificial intelligence models in healthcare Nat. Med. (IF 82.9) Pub Date : 2024-03-22 Meera Krishnamoorthy, Michael W. Sjoding, Jenna Wiens
In healthcare, many artificial intelligence models could be used in settings other than those for which they were approved. But such off-label use must include an empirical or mechanistic evaluation to ensure patient safety.
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Revealing clinical heterogeneity in a large brain bank cohort Nat. Med. (IF 82.9) Pub Date : 2024-03-20
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Towards a general-purpose foundation model for computational pathology Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Richard J. Chen, Tong Ding, Ming Y. Lu, Drew F. K. Williamson, Guillaume Jaume, Andrew H. Song, Bowen Chen, Andrew Zhang, Daniel Shao, Muhammad Shaban, Mane Williams, Lukas Oldenburg, Luca L. Weishaupt, Judy J. Wang, Anurag Vaidya, Long Phi Le, Georg Gerber, Sharifa Sahai, Walt Williams, Faisal Mahmood
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How to support the transition to AI-powered healthcare Nat. Med. (IF 82.9) Pub Date : 2024-03-19
To make health systems more sustainable in the long-term, incentivize artificial intelligence (AI) and digital technologies that are grounded on careful testing and real-world validation.
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Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Ronan J. Kelly, Blair V. Landon, Ali H. Zaidi, Dipika Singh, Jenna V. Canzoniero, Archana Balan, Russell K. Hales, K. Ranh Voong, Richard J. Battafarano, Blair A. Jobe, Stephen C. Yang, Stephen Broderick, Jinny Ha, Kristen A. Marrone, Gavin Pereira, Nisha Rao, Aryan Borole, Katerina Karaindrou, Zineb Belcaid, James R. White, Suqi Ke, Ali I. Amjad, Benny Weksler, Eun Ji Shin, Elizabeth Thompson, Kellie
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A visual-language foundation model for computational pathology Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Ming Y. Lu, Bowen Chen, Drew F. K. Williamson, Richard J. Chen, Ivy Liang, Tong Ding, Guillaume Jaume, Igor Odintsov, Long Phi Le, Georg Gerber, Anil V. Parwani, Andrew Zhang, Faisal Mahmood
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Heterogeneity and predictors of the effects of AI assistance on radiologists Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Feiyang Yu, Alex Moehring, Oishi Banerjee, Tobias Salz, Nikhil Agarwal, Pranav Rajpurkar