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Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-04-18 Richard K. Cheng, Michelle M. Kittleson, Craig J. Beavers, David H. Birnie, Ron Blankstein, Paco E. Bravo, Nisha A. Gilotra, Marc A. Judson, Kristen K. Patton, Leonie Rose-Bovino, on behalf of the American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology, and Council on Cardiovascular and Stroke Nursing
Cardiac sarcoidosis is an infiltrative cardiomyopathy that results from granulomatous inflammation of the myocardium and may present with high-grade conduction disease, ventricular arrhythmias, and right or left ventricular dysfunction. Over the past several decades, the prevalence of cardiac sarcoidosis has increased. Definitive histological confirmation is often not possible, so clinicians frequently
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Genetic Deletion of β-Arrestin 2 From the Subfornical Organ and Other Periventricular Nuclei in the Brain Alters Fluid Homeostasis and Blood Pressure Hypertension (IF 8.3) Pub Date : 2024-04-17 Natalia M. Mathieu, Eden E. Tan, John J. Reho, Daniel T. Brozoski, Patricia C. Muskus, Ko-Ting Lu, Kelsey K. Wackman, Justin L. Grobe, Pablo Nakagawa, Curt D. Sigmund
BACKGROUND:ANG (angiotensin II) elicits dipsogenic and pressor responses via activation of the canonical Gαq (G-protein component of the AT1R [angiotensin type 1 receptor])-mediated AT1R in the subfornical organ. Recently, we demonstrated that ARRB2 (β-arrestin 2) global knockout mice exhibit a higher preference for salt and exacerbated pressor response to deoxycorticosterone acetate salt. However
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Dissociation of Hypertension and Renal Damage After Cessation of High-Salt Diet in Dahl Rats Hypertension (IF 8.3) Pub Date : 2024-04-15 Sergey N. Arkhipov, Tang-Dong S. Liao, D’Anna L. Potter, Kevin R. Bobbitt, Veniamin Ivanov, Pablo A. Ortiz, Tengis S. Pavlov
BACKGROUND:Every year, thousands of patients with hypertension reduce salt consumption in the efforts to control their blood pressure. However, hypertension has a self-sustaining character in a significant part of the population. We hypothesized that chronic hypertension leads to irreversible renal damage that remains after removing the trigger, causing an elevation of the initial blood pressure.METHODS:Dahl
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Orphan Nuclear Receptor NR4A3 Promotes Vascular Calcification via Histone Lactylation Circ. Res. (IF 20.1) Pub Date : 2024-04-17 Wenqi Ma, Kangni Jia, Haomai Cheng, Hong Xu, Zhigang Li, Hang Zhang, Hongyang Xie, Lingfang Zhuang, Ziyang Wang, Yuke Cui, Hang Sun, Lei Yi, Zhiyong Chen, Shengzhong Duan, Motoaki Sano, Keiichi Fukuda, Lin Lu, Fei Gao, Ruiyan Zhang, Xiaoxiang Yan
BACKGROUND:Medial arterial calcification is a chronic systemic vascular disorder distinct from atherosclerosis and is commonly observed in patients with chronic kidney disease, diabetes, and aging individuals. We previously showed that NR4A3 (nuclear receptor subfamily 4 group A member 3), an orphan nuclear receptor, is a key regulator in apo (apolipoprotein) A-IV-induced atherosclerosis progression;
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Immunoproteasomal Processing of IsoLG-Adducted Proteins Is Essential for Hypertension Circ. Res. (IF 20.1) Pub Date : 2024-04-16 Néstor de la Visitación, Wei Chen, Jaya Krishnan, Justin P. Van Beusecum, Venkataraman Amarnath, Elizabeth M. Hennen, Shilin Zhao, Mohammad Saleem, Mingfang Ao, Sergey I. Dikalov, Anna E. Dikalova, David G. Harrison, David M. Patrick
BACKGROUND:Hypertension is characterized by CD8+ T cell activation and infiltration into peripheral tissues. CD8+ T cell activation requires proteasomal processing of antigenic proteins. It has become clear that isoLG (isolevuglandin)-adduced peptides are antigenic in hypertension; however, IsoLGs inhibit the constitutive proteasome. We hypothesized that immunoproteasomal processing of isoLG-adducts
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Buffering Mechanism in Aortic Arch Artery Formation and Congenital Heart Disease Circ. Res. (IF 20.1) Pub Date : 2024-04-15 AnnJosette Ramirez, Christina A. Vyzas, Huaning Zhao, Kevin Eng, Karl Degenhardt, Sophie Astrof
BACKGROUND:The resiliency of embryonic development to genetic and environmental perturbations has been long appreciated; however, little is known about the mechanisms underlying the robustness of developmental processes. Aberrations resulting in neonatal lethality are exemplified by congenital heart disease arising from defective morphogenesis of pharyngeal arch arteries (PAAs) and their derivatives
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Inhibition of the mPTP and Lipid Peroxidation Is Additively Protective Against I/R Injury Circ. Res. (IF 20.1) Pub Date : 2024-04-15 Arielys Mendoza, Pooja Patel, Dexter Robichaux, Daniel Ramirez, Jason Karch
BACKGROUND:During myocardial ischemia/reperfusion (I/R) injury, high levels of matrix Ca2+ and reactive oxygen species (ROS) induce the opening of the mitochondrial permeability transition pore (mPTP), which causes mitochondrial dysfunction and ultimately necrotic death. However, the mechanisms of how these triggers individually or cooperatively open the pore have yet to be determined.METHODS:Here
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Systolic Blood Pressure and Survival to Very Old Age: Results From the Women’s Health Initiative Circulation (IF 37.8) Pub Date : 2024-04-16 Bernhard Haring, Chris A. Andrews, Kathleen Hovey, Aladdin H. Shadyab, Andrea LaCroix, Lisa Warsinger Martin, Milagros C. Rosal, Lewis H. Kuller, Elena Salmoirago-Blotcher, Nazmus Saquib, Patrick Koo, Deepika Laddu, Marcia L. Stefanick, JoAnn E. Manson, Sylvia Wassertheil-Smoller, Michael J. LaMonte
BACKGROUND:The relationship between systolic blood pressure (SBP) and longevity is not fully understood. We aimed to determine which SBP levels in women ≥65 years of age with or without blood pressure medication were associated with the highest probability of surviving to 90 years of age.METHODS:The study population consisted of 16570 participants enrolled in the Women’s Health Initiative who were
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Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era Circulation (IF 37.8) Pub Date : 2024-04-12 Felix Gerhardt, Eva Fiessler, Karen M. Olsson, Moritz Z. Kayser, Gabor Kovacs, Henning Gall, H. Ardeschir Ghofrani, Roza Badr Eslam, Irene M. Lang, Nicola Benjamin, Ekkehard Grünig, Michael Halank, Tobias J. Lange, Silvia Ulrich, Hanno Leuchte, Matthias Held, Hans Klose, Ralf Ewert, Heinrike Wilkens, Carmen Pizarro, Dirk Skowasch, Max Wissmüller, Martin Hellmich, Horst Olschewski, Marius M. Hoeper
BACKGROUND:Among patients with pulmonary arterial hypertension (PAH), acute vasoreactivity testing during right heart catheterization may identify acute vasoresponders, for whom treatment with high-dose calcium channel blockers (CCBs) is recommended. However, long-term outcomes in the current era remain largely unknown. We sought to evaluate the implications of acute vasoreactivity response for long-term
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Artificial Intelligence and Machine Learning in Cardiology Circulation (IF 37.8) Pub Date : 2024-04-15 Rahul C. Deo
Seven years ago, I wrote a review in this journal on the state of machine learning in medicine.1 My tenet then was that although numerous medical applications could benefit from machine learning, and the requisites for such models—data and algorithms—were widely present, few examples had made their way into practice. I struggled to find illustrative examples from cardiovascular research, let alone
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The Urban Environment and Cardiometabolic Health Circulation (IF 37.8) Pub Date : 2024-04-15 Sanjay Rajagopalan, Armando Vergara-Martel, Jeffrey Zhong, Haitham Khraishah, Mikhail Kosiborod, Ian J. Neeland, Jean-Eudes Dazard, Zhuo Chen, Thomas Munzel, Robert D. Brook, Mark Nieuwenhuijsen, Peter Hovmand, Sadeer Al-Kindi
Urban environments contribute substantially to the rising burden of cardiometabolic diseases worldwide. Cities are complex adaptive systems that continually exchange resources, shaping exposures relevant to human health such as air pollution, noise, and chemical exposures. In addition, urban infrastructure and provisioning systems influence multiple domains of health risk, including behaviors, psychological
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Correction to: 2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces Circulation (IF 37.8) Pub Date : 2024-04-15
In the article by Berg et al, “2023 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task Forces,” which published ahead of print on November 9, 2023, and appeared
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Correction to: Toward Heart-Healthy and Sustainable Cities: A Policy Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-04-15
In the article by Rajagopalan et al, “Toward Heart-Healthy and Sustainable Cities: A Policy Statement From the American Heart Association,” which published ahead of print on March 4, 2024, and appeared in the April 9, 2024, issue of the journal (Circulation. 2024;149:e1067–e1089. DOI: 10.1161/CIR.0000000000001217), a correction was needed. On page e17, in the Writing Group Disclosures table, in the
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Correction to: Effects of Synchronizing Foot Strike and Cardiac Phase on Exercise Hemodynamics in Patients With Cardiac Resynchronization Therapy: A Within-Subjects Pilot Study to Fine-Tune Cardio-Locomotor Coupling for Heart Failure Circulation (IF 37.8) Pub Date : 2024-04-15
In the article by Wakeham et al, “Effects of Synchronizing Foot Strike and Cardiac Phase on Exercise Hemodynamics in Patients With Cardiac Resynchronization Therapy: A Within-Subjects Pilot Study to Fine-Tune Cardio-Locomotor Coupling for Heart Failure,” which appeared in the October 13, 2023, issue of the journal (Circulation. 2023;148:2008–2016. doi: 10.1161/CIRCULATIONAHA.123.066170), 2 corrections
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Correction to: Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts Circulation (IF 37.8) Pub Date : 2024-04-15
In the article by Omiya et al, “Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts,” which appeared in the January 14, 2020, issue of the journal (Circulation. 2020;141:667-677. doi: 10.1161/CIRCULATIONAHA.119.044582), a correction is needed. An overlap was discovered between 2 CD45 and CD68 staining panels for TAC-operated Reg−/− mice in Figure
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Atrial Shunt Device Effects on Cardiac Structure and Function in Heart Failure With Preserved Ejection Fraction JAMA Cardiol. (IF 24.0) Pub Date : 2024-04-17 Ravi B. Patel, Frank E. Silvestry, Jan Komtebedde, Scott D. Solomon, Gerd Hasenfuß, Sheldon E. Litwin, Barry A. Borlaug, Matthew J. Price, Rami Kawash, Scott L. Hummel, Donald E. Cutlip, Martin B. Leon, Dirk J. van Veldhuisen, Andreas J. Rieth, Scott McKenzie, Heiko Bugger, Jeremy A. Mazurek, Samir R. Kapadia, Marc Vanderheyden, Bonnie Ky, Sanjiv J. Shah
ImportanceAlthough the results of A Study to Evaluate the Corvia Medical Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients with Heart Failure (REDUCE LAP-HF II) trial were neutral overall, atrial shunt therapy demonstrated potential efficacy in responders (no latent pulmonary vascular disease and no cardiac rhythm management device). Post hoc analyses were conducted to evaluate
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Man in His Sixth Decade of Life With Totally Occluded Abdominal Aorta (Leriche Syndrome) JAMA Cardiol. (IF 24.0) Pub Date : 2024-04-17 Karley Fischer, Zuha Nazir, Damian Valencia
This case report discusses a diagnosis of Leriche syndrome in a male patient with peripheral arterial disease, erectile dysfunction, and nonischemic cardiomyopathy.
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Mast cells: a novel therapeutic avenue for cardiovascular diseases? Cardiovasc. Res. (IF 10.8) Pub Date : 2024-04-17 Remo Poto, Gianni Marone, Stephen J Galli, Gilda Varricchi
Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells produce a broad spectrum of vasoactive and proinflammatory mediators, which have potential roles in inflammation, angiogenesis, lymphangiogenesis, tissue remodeling
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Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-04-15 Justin P. Zachariah, Pei-Ni Jone, Andrew O. Agbaje, Heather H. Ryan, Leonardo Trasande, Wei Perng, Shohreh F. Farzan, on behalf of the American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Lifestyle and Cardiometabolic Health, and Council on Clinical Cardiology
Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely prevalent and has a long latency period between exposure and health outcome, potentially placing a large number of individuals at risk of these health consequences. Emerging evidence
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Gut bacteria can break down cholesterol Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-04-16 Irene Fernández-Ruiz
A new study identifies a group of gut bacteria that can metabolize cholesterol and are associated with lower plasma cholesterol levels.
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Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study Eur. Heart J. (IF 39.3) Pub Date : 2024-04-16 Yuebin Lv, Yue Zhang, Xinwei Li, Xiang Gao, Yongyong Ren, Luojia Deng, Lanjing Xu, Jinhui Zhou, Bing Wu, Yuan Wei, Xingyao Cui, Zinan Xu, Yanbo Guo, Yidan Qiu, Lihong Ye, Chen Chen, Jun Wang, Chenfeng Li, Yufei Luo, Zhaoxue Yin, Chen Mao, Qiong Yu, Hui Lu, Virginia Byers Kraus, Yi Zeng, Shilu Tong, Xiaoming Shi
Background and Aims Emerging evidence has raised an obesity paradox in observational studies of body mass index (BMI) and health among the oldest-old (aged ≥80 years), as an inverse relationship of BMI with mortality was reported. This study was to investigate the causal associations of BMI, waist circumference (WC), or both with mortality in the oldest-old people in China. Methods A total of 5306
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Endothelial NLRP3 inflammasome regulation in atherosclerosis Cardiovasc. Res. (IF 10.8) Pub Date : 2024-04-16 Shuai Guo, Litao Wang, Kaixiang Cao, Ziling Li, Mingchuan Song, Shuqi Huang, Zou Li, Cailing Wang, Peiling Chen, Yong Wang, Xiaoyan Dai, Xianglin Chen, Xiaodong Fu, Du Feng, Jun He, Yuqing Huo, Yiming Xu
Aim The activation of Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in endothelial cells (ECs) contributes to vascular inflammation in atherosclerosis. Considering the high glycolytic rate of ECs, we delineated whether and how glycolysis determines endothelial NLRP3 inflammasome activation in atherosclerosis. Methods and Results Our results demonstrated a significant
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ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport Cardiovasc. Res. (IF 10.8) Pub Date : 2024-04-16 Bin Liu, Mujahid Azfar, Ekaterina Legchenko, James A West, Shaun Martin, Chris Van den Haute, Veerle Baekelandt, John Wharton, Luke Howard, Martin R Wilkins, Peter Vangheluwe, Nicholas W Morrell, Paul D Upton
Aims Potential loss-of-function variants of ATP13A3, the gene encoding a P5B-type transport ATPase of undefined function, were recently identified in pulmonary arterial hypertension (PAH) patients. ATP13A3 is implicated in polyamine transport but its function has not been fully elucidated. Here, we sought to determine the biological function of ATP13A3 in vascular endothelial cells and how PAH-associated
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Coexisting atrial fibrillation and cancer: time trends and associations with mortality in a nationwide Dutch study Eur. Heart J. (IF 39.3) Pub Date : 2024-04-15 Qingui Chen, Nienke van Rein, Tom van der Hulle, Julius C Heemelaar, Serge A Trines, Henri H Versteeg, Frederikus A Klok, Suzanne C Cannegieter
Background and Aims Coexisting atrial fibrillation (AF) and cancer challenge the management of both. The aim of the study is to comprehensively provide the epidemiology of coexisting AF and cancer. Methods Using Dutch nationwide statistics, individuals with incident AF (n = 320 139) or cancer (n = 472 745) were identified during the period 2015–19. Dutch inhabitants without a history of AF (n = 320
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Meet the First Authors Circ. Res. (IF 20.1) Pub Date : 2024-04-11
Dr Kajsa Arkelius completed her Ph.D. in Experimental Vascular Research from the Applied Neurovascular Research group at the University of Lund, Sweden, under the guidance of Dr Saema Ansar. Her doctoral research primarily focused on developing innovative therapeutic approaches to enhance thrombolysis therapy following ischemic stroke. Currently, Dr Arkelius is a postdoctoral fellow in Neurology at
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Environmental Exposome and Atrial Fibrillation: Emerging Evidence and Future Directions Circ. Res. (IF 20.1) Pub Date : 2024-04-11 Sojin Youn Wass, Omar Hahad, Zain Asad, Shuo Li, Mina K. Chung, Emelia J. Benjamin, Khurram Nasir, Sanjay Rajagopalan, Sadeer G. Al-Kindi
There has been increased awareness of the linkage between environmental exposures and cardiovascular health and disease. Atrial fibrillation is the most common sustained cardiac arrhythmia, affecting millions of people worldwide and contributing to substantial morbidity and mortality. Although numerous studies have explored the role of genetic and lifestyle factors in the development and progression
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Correction to: Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery Circ. Res. (IF 20.1) Pub Date : 2024-04-11
In the article by Kim et al, “Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery,” which published in the March 15, 2024 issue of the journal (Circ Res. 2023;134:727-747. doi: 10.1161/CIRCRESAHA.123.323521), a correction was needed. There is an error in Figure 3 where the descriptions of the solid line and the dotted line are inaccurate and have therefore been removed from the figure footnote
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Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study Cardiovasc. Res. (IF 10.8) Pub Date : 2024-04-13 Larissa Fabritz, Winnie Chua, Victor R Cardoso, Christoph Al-Taie, Katrin Borof, Anna Suling, Linda Krause, Shino Kany, Christina Magnussen, Karl Wegscheider, Guenter Breithardt, Harry J G M Crijns, A John Camm, George Gkoutos, Patrick T Ellinor, Andreas Goette, Ulrich Schotten, Ursula-Henrike Wienhues-Thelen, Tanja Zeller, Renate B Schnabel, Antonia Zapf, Paulus Kirchhof
Background Atrial fibrillation (AF) and concomitant cardiometabolic disease processes interact and combine to lead to adverse events such as stroke, heart failure, myocardial infarction, and cardiovascular death. Circulating biomolecules provide quantifiable proxies for cardiometabolic disease processes. Their role in defining subphenotypes of AF is not known. Methods and results This prespecified
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Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results from the TARGET BP I Randomized Clinical Trial Circulation (IF 37.8) Pub Date : 2024-04-08 David E. Kandzari, Michael A. Weber, Atul Pathak, James P. Zidar, Manish Saxena, Shukri W. David, Roland E. Schmieder, Adam J. Janas, Christoph Langer, Alexandre Persu, Farrell O. Mendelsohn, Koen Ameloot, Malcolm Foster III, Tim A. Fischell, Helen Parise, Felix Mahfoud
Background: Renal denervation (RDN) has demonstrated clinically relevant reductions in blood pressure among individuals with uncontrolled hypertension despite lifestyle intervention and medications. The safety and effectiveness of alcohol-mediated RDN has not been formally studied in this indication.Methods: TARGET BP I is a prospective, international, sham-controlled, randomized, patient- and assessor-blinded
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Effect of Gamification, Financial Incentives, or Both to Increase Physical Activity Among Patients at High Risk of Cardiovascular Events: The BE ACTIVE Randomized Controlled Trial Circulation (IF 37.8) Pub Date : 2024-04-07 Alexander C. Fanaroff, Mitesh S. Patel, Neel Chokshi, Samantha Coratti, David Farraday, Laurie Norton, Charles Rareshide, Jingsan Zhu, Tamar Klaiman, Julia E. Szymczak, Louise B. Russell, Dylan S. Small, Kevin G.M. Volpp
Background: Physical activity is associated with a lower risk of major adverse cardiovascular events, but few individuals achieve guideline recommended levels of physical activity. Strategies informed by behavioral economics increase physical activity, but their longer-term effectiveness is uncertain. We sought to determine the effect of behaviorally-designed gamification, loss-framed financial incentives
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Sodium Glucose Co-transporter 2 Inhibitors and Major Adverse Cardiovascular Outcomes: A SMART-C Collaborative Meta-Analysis Circulation (IF 37.8) Pub Date : 2024-04-07 Siddharth M. Patel, Yu Mi Kang, KyungAh Im, Brendon L. Neuen, Stefan D. Anker, Deepak L. Bhatt, Javed Butler, David Z.I. Cherney, Brian L. Claggett, Robert A. Fletcher, William G. Herrington, Silvio E. Inzucchi, Meg J. Jardine, Kenneth W. Mahaffey, Darren K. McGuire, John J.V. McMurray, Bruce Neal, Milton Packer, Vlado Perkovic, Scott D. Solomon, Natalie Staplin, Muthiah Vaduganathan, Christoph Wanner
Background: Sodium glucose co-transporter 2 inhibitors (SGLT2i) consistently improve heart failure and kidney-related outcomes; however, effects on major adverse cardiovascular events (MACE) across different patient populations are less clear.Methods: This was a collaborative trial-level meta-analysis from the SGLT2i meta-analysis cardio-renal trialists consortium, which includes all phase 3, placebo-controlled
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Ischaemic stroke in women with atrial fibrillation: temporal trends and clinical implications Eur. Heart J. (IF 39.3) Pub Date : 2024-04-12 Konsta Teppo, K E Juhani Airaksinen, Jussi Jaakkola, Olli Halminen, Birgitta Salmela, Elis Kouki, Jari Haukka, Jukka Putaala, Miika Linna, Aapo L Aro, Pirjo Mustonen, Juha Hartikainen, Gregory Y H Lip, Mika Lehto
Background and Aims Female sex has been linked with higher risk of ischaemic stroke (IS) in atrial fibrillation (AF), but no prior study has examined temporal trends in the IS risk associated with female sex. Methods The registry-linkage Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) study included all patients with AF in Finland from 2007 to 2018. Ischaemic stroke rates and rate ratios were
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Rescue of cardiac dysfunction during chemotherapy in acute myeloid leukaemia by blocking IL-1α Eur. Heart J. (IF 39.3) Pub Date : 2024-04-12 Xingliang Zhou, Yiwei Liu, Yi Shen, Lijun Chen, Wenting Hu, Yi Yan, Bei Feng, Li Xiang, Yifan Zhu, Chenyu Jiang, Zihao Dai, Xu Huang, Liwei Wu, Tianyu Liu, Lijun Fu, Caiwen Duan, Shuhong Shen, Jun Li, Hao Zhang
Background and Aims Patients with acute myeloid leukaemia (AML) suffer from severe myocardial injury during daunorubicin (DNR)-based chemotherapy and are at high risk of cardiac mortality. The crosstalk between tumour cells and cardiomyocytes might play an important role in chemotherapy-related cardiotoxicity, but this has yet to be demonstrated. This study aimed to identify its underlying mechanism
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Atrial Fibrillation Screening During Routine Automated Office, Home, and Ambulatory Blood Pressure Measurement: A Diagnostic Test Accuracy Systematic Review and Meta-Analysis Hypertension (IF 8.3) Pub Date : 2024-04-11 Konstantinos G. Kyriakoulis, Anastasios Kollias, Ariadni Menti, Panagiotis Chardouvelis, George S. Stergiou
BACKGROUND:Atrial fibrillation (AF) is often asymptomatic and undiagnosed. As AF and hypertension often coexist, opportunistic AF detection during routine automated blood pressure (BP) measurement appears to be an attractive screening method.METHODS:A systematic literature search was conducted to identify studies assessing the diagnostic test accuracy of office, home, or 24-hour ambulatory BP measuring
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Patient-Centered Adult Cardiovascular Care: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-04-11 Michael J. Goldfarb, Martha Abshire Saylor, Biykem Bozkurt, Jillianne Code, Katherine E. Di Palo, Angela Durante, Kristin Flanary, Ruth Masterson Creber, Modele O. Ogunniyi, Fatima Rodriguez, Martha Gulati, on behalf of the American Heart Association Council on Clinical Cardiology, Council on Cardiovascular and Stroke Nursing, Council on Hypertension, Council on Lifestyle and Cardiometabolic Health
Patient-centered care is gaining widespread acceptance by the medical and lay communities and is increasingly recognized as a goal of high-quality health care delivery. Patient-centered care is based on ethical principles and aims at establishing a partnership between the health care team and patient, family member, or both in the care planning and decision-making process. Patient-centered care involves
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In This Issue Circ. Res. (IF 20.1) Pub Date : 2024-04-11
Eliminating the blood clot responsible for an ischemic stroke can improve a patient’s outcome, even save their life. But, the treatment—an intravenous dose of tissue plasminogen activator (rt-PA)—can only be given in the first few hours of symptoms. After that, the risk of hemorrhage associated with rt-PA is no longer offset by its benefits. Increased matrix metalloprotease 9 (MMP-9), which breaks
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Canonical and non-canonical roles of complement in atherosclerosis Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-04-10 Pasquale Maffia, Claudio Mauro, Ayden Case, Claudia Kemper
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Cardiovascular disease and cancer: shared risk factors and mechanisms Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-04-10 Nicholas S. Wilcox, Uri Amit, Jacob B. Reibel, Eva Berlin, Kendyl Howell, Bonnie Ky
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Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction Circ. Res. (IF 20.1) Pub Date : 2024-04-10 Tianpeng Wang, Jingchen Shao, Shamit Kumar, Mohammad Wessam Alnouri, Jorge Carvalho, Stefan Günther, Cornelius Krasel, Kate T. Murphy, Moritz Bünemann, Stefan Offermanns, Nina Wettschureck
BACKGROUND:GPCRs (G-protein-coupled receptors) play a central role in the regulation of smooth muscle cell (SMC) contractility, but the function of SMC-expressed orphan GPCR class C group 5 member C (GPRC5C) is unclear.OBJECTIVE:The aim of this project is to define the role of GPRC5C in SMC in vitro and in vivo.METHODS AND RESULTS:We studied the role of GPRC5C in the regulation of SMC contractility
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Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation Circulation (IF 37.8) Pub Date : 2024-04-08 Yike Zhu, Matthew Ackers-Johnson, Muthu K. Shanmugam, Leroy Sivappiragasam Pakkiri, Chester Lee Drum, Yanpu Chen, Johnny Kim, Wyatt G. Paltzer, Ahmed I. Mahmoud, Wilson Lek Wen Tan, Mick Chang Jie Lee, Jianming Jiang, Danh Anh Tuan Luu, Shi Ling Ng, Peter Yi Qing Li, Anhui Wang, Rong Qi, Gabriel Jing Xiang Ong, Timothy Ng Yu, Jody J. Haigh, Zenia Tiang, A. Mark Richards, Roger Foo
BACKGROUND:Adult mammalian cardiomyocytes have limited proliferative capacity, but in specifically induced contexts they traverse through cell-cycle reentry, offering the potential for heart regeneration. Endogenous cardiomyocyte proliferation is preceded by cardiomyocyte dedifferentiation (CMDD), wherein adult cardiomyocytes revert to a less matured state that is distinct from the classical myocardial
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Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial Circulation (IF 37.8) Pub Date : 2024-04-08 André Lamy, Dmitry A. Sirota, Frederic Jacques, Ahmad Poostizadeh, Nicolas Noiseux, Sergey Efremov, Philippe Demers, Boris Akselrod, Chew Yin Wang, Rakesh C. Arora, Piotr Branny, Shay P. McGuinness, Craig D. Brown, Hugues Jeanmart, Qiang Zhao, Haibo Zhang, Emilie P. Belley-Côté, Richard P. Whitlock, Austin Browne, Ingrid Copland, Jessica Vincent, Rutaba Khatun, Kumar Balasubramanian, Shrikant I. Bangdiwala
Background: Although intravenous tranexamic acid is used in cardiac surgery to reduce bleeding and transfusion, topical tranexamic acid results in lower plasma concentrations compared to intravenous tranexamic acid, which may lower the risk of seizures. We aimed to determine whether topical tranexamic acid reduces the risk of in-hospital seizure without increasing the risk of transfusion among cardiac
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Randomized Evaluation of a Remote Management Program to Improve Guideline-directed Medical Therapy: The Diabetes Remote Intervention to Improve Use of Evidence-based Medications (DRIVE) Trial Circulation (IF 37.8) Pub Date : 2024-04-07 Alexander J. Blood, Lee-Shing Chang, Shahzad Hassan, Jacqueline Chasse, Gretchen Stern, Daniel Gabovitch, David Zelle, Caitlin Colling, Samuel J. Aronson, Christian Figueroa, Emma Collins, Ryan Ruggiero, Emily Zacherle, Josh Noone, Carey Robar, Jorge Plutzky, Thomas A. Gaziano, Christopher P. Cannon, Deborah J. Wexler, Benjamin M. Scirica
Background: Several sodium-glucose transport protein 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) reduce cardiovascular (CV) events and improve kidney outcomes in patients with type 2 diabetes (T2D); however, utilization remains low despite guideline recommendations.Methods: A randomized, remote implementation trial in the Mass General Brigham network enrolled patients
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Clinical Impact of Routine Assessment of Patient-Reported Health Status in Heart Failure Clinic Circulation (IF 37.8) Pub Date : 2024-04-07 Alexander T. Sandhu, Jamie Calma, Megan Skye, Neil M Kalwani, Jimmy Zheng, Jessica Schirmer, Natasha Din, Cati Brown Johnson, Anshal Gupta, Roy Lan, Brian Yu, John A. Spertus, Paul A. Heidenreich
Background: The impact of routine clinic use of patient-reported outcome (PRO) measures on clinical outcomes in patients with heart failure (HF) has not been well-characterized. We tested if clinic-based use of a disease-specific PRO improves patient-reported quality of life at 1 year.Methods: PRO-HF was an open-label, parallel, patient-level randomized clinical trial of routine PRO assessment or usual
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Peripheral Artery Disease: Past and Future Circulation (IF 37.8) Pub Date : 2024-04-08 Mary M. McDermott
Lower extremity peripheral artery disease (PAD) affects between 116 and 230 million people worldwide.1 Manifestations of PAD range from asymptomatic, in which patients report no exertional leg symptoms, to chronic limb-threatening ischemia (CLTI), defined by lower-limb rest pain, gangrene, or ulceration.2 Compared with age-matched people without PAD, those with PAD have significantly higher rates of
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Correction to: Telehealth: Lessons Learned From the Pandemic and Keys to Effective Research and Policy Design Circulation (IF 37.8) Pub Date : 2024-04-08
In the article by Churchwell and Yeager McSwain, “Telehealth: Lessons Learned From the Pandemic and Keys to Effective Research and Policy Design,” which appeared in the June 20, 2023, issue of the journal (Circulation. 2023;147:1948-1950. doi: 10.1161/CIRCULATIONAHA.123.065264), a correction is needed. The article incorrectly acknowledges the U01 Collaborative Innovation Award (U01TR002626) from the
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Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization Circulation (IF 37.8) Pub Date : 2024-04-10 Matthew T. Menard, Alik Farber, Richard J. Powell, Kenneth Rosenfield, Michael S. Conte, Taye H. Hamza, John A. Kaufman, Mark J. Cziraky, Mark A. Creager, Michael D. Dake, Michael R. Jaff, Diane Reid, George Sopko, Christopher J. White, Michael B. Strong, Max van Over, Emiliano Chisci, Philip P. Goodney, Bruce Gray, Ahmed Kayssi, Jeffrey J. Siracuse, Niteesh K. Choudhry
BACKGROUND:In the BEST-CLI trial (Best Endovascular Versus Best Surgical Therapy for Patients With Chronic Limb-Threatening Ischemia), a prespecified secondary objective was to assess the effects of revascularization strategy on health-related quality of life (HRQoL).METHODS:Patients with chronic limb-threatening ischemia were randomized to surgical bypass (Bypass) or endovascular intervention (Endo)
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Atrial Fibrillation and Clonal Hematopoiesis in TET2 and ASXL1 JAMA Cardiol. (IF 24.0) Pub Date : 2024-04-10 Seyedmohammad Saadatagah, Mohammadreza Naderian, Mesbah Uddin, Ozan Dikilitas, Abhishek Niroula, Art Schuermans, Elizabeth Selvin, Ron C. Hoogeveen, Kunihiro Matsushita, Vijay Nambi, Bing Yu, Lin Yee Chen, Alexander G. Bick, Benjamin L. Ebert, Michael C. Honigberg, Na Li, Amil Shah, Pradeep Natarajan, Iftikhar J. Kullo, Christie M. Ballantyne
ImportanceClonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling.ObjectiveTo determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes.Design, Setting, and ParticipantsThis was a population-based, prospective cohort study in
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Atrial fibrillation: age at diagnosis, incident cardiovascular events, and mortality Eur. Heart J. (IF 39.3) Pub Date : 2024-04-09 Christian Paludan-Müller, Oliver B Vad, Niels K Stampe, Søren Z Diederichsen, Laura Andreasen, Laia M Monfort, Emil L Fosbøl, Lars Køber, Christian Torp-Pedersen, Jesper H Svendsen, Morten S Olesen
Background and Aims Patients with atrial fibrillation (AF) are at increased risks of cardiovascular diseases and mortality, but risks according to age at diagnosis have not been reported. This study investigated age-specific risks of outcomes among patients with AF and the background population. Methods This nationwide population-based cohort study included patients with AF and controls without outcomes
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Use of new and emerging cancer drugs: what the cardiologist needs to know Eur. Heart J. (IF 39.3) Pub Date : 2024-04-09 Iacopo Fabiani, Michela Chianca, Alberto Aimo, Michele Emdin, Susan Dent, Antonella Fedele, Carlo Maria Cipolla, Daniela Maria Cardinale
The last decade has witnessed a paradigm shift in cancer therapy, from non-specific cytotoxic chemotherapies to agents targeting specific molecular mechanisms. Nonetheless, cardiovascular toxicity of cancer therapies remains an important concern. This is particularly relevant given the significant improvement in survival of solid and haematological cancers achieved in the last decades. Cardio-oncology
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Recommendations for the Use of Dietary Fiber to Improve Blood Pressure Control Hypertension (IF 8.3) Pub Date : 2024-04-08 Hamdi A. Jama, Matthew Snelson, Aletta E. Schutte, Jane Muir, Francine Z. Marques
According to several international, regional, and national guidelines on hypertension, lifestyle interventions are the first-line treatment to lower blood pressure (BP). Although diet is one of the major lifestyle modifications described in hypertension guidelines, dietary fiber is not specified. Suboptimal intake of foods high in fiber, such as in Westernized diets, is a major contributing factor
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Interplay Between Plasma Glycine and Branched-Chain Amino Acids Contributes to the Development of Hypertension and Coronary Heart Disease Hypertension (IF 8.3) Pub Date : 2024-04-08 Mateusz Dziedzic, Ewelina Józefczuk, Tomasz J. Guzik, Mateusz Siedlinski
BACKGROUND:Higher levels of plasma glycine are linked to a reduced risk, while increased levels of total branched-chain amino acids (tBCAAs) are associated with a higher risk of essential hypertension (HTN) and coronary heart disease (CHD). As these metabolic components are interconnected, analyzing the tBCAAs/glycine ratio may help to understand their interplay in the pathogenesis of cardiovascular
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Impact of Renal Denervation on Urinary Peptide-Based Biomarkers in Hypertension Hypertension (IF 8.3) Pub Date : 2024-04-04 Lucas Lauder, Justyna Siwy, Emmanouil Mavrogeorgis, Felix Keller, Michael Kunz, Angelika Wachter, Insa Emrich, Michael Böhm, Harald Mischak, Felix Mahfoud
BACKGROUND:Catheter-based renal denervation (RDN) reduces blood pressure in hypertension. Urinary peptides are associated with cardiovascular and renal disease and provide prognostic information. We aimed to investigate the effect of RDN on urinary peptide-based biomarker panels associated with chronic kidney and heart disease and to identify urinary peptides affected by RDN.METHODS:This single-arm
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Maintenance of Normal Blood Pressure From Middle to Older Age: Results From the Atherosclerosis Risk in Communities Study Hypertension (IF 8.3) Pub Date : 2024-04-03 Kathryn Foti, Josef Coresh, Paul K. Whelton, Kunihiro Matsushita, Shakia T. Hardy, Kristi Reynolds, C. Barrett Bowling, Keenan A. Walker, Anna Kucharska-Newton, B. Gwen Windham, Michael Griswold, Joseph E. Schwartz, Paul Muntner
BACKGROUND:It is unknown whether maintaining normal blood pressure (BP) from middle to older age is associated with improved health outcomes.METHODS:We estimated the proportion of Atherosclerosis Risk in Communities study participants who maintained normal BP from 1987 to 1989 (visit 1) through 1996 to 1998 and 2011 to 2013 (over 4 and 5 visits, respectively). Normal BP was defined as systolic BP <120
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The 2023 Lewis K. Dahl Memorial Lecture: Angiotensin-Converting Enzyme 2 Posttranslational Modifications—Implications for Hypertension and SARS-CoV-2 Infection Hypertension (IF 8.3) Pub Date : 2024-04-03 Mona Elgazzaz, Catalin Filipeanu, Eric Lazartigues
ACE2 (angiotensin-converting enzyme 2), a multifunctional transmembrane protein, is well recognized as an important member of the (RAS) renin–angiotensin system with important roles in the regulation of cardiovascular function by opposing the harmful effects of Ang-II (angiotensin II) and AT1R (Ang-II type 1 receptor) activation. More recently, ACE2 was found to be the entry point for the SARS-CoV-2
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Chronological vs Biological Age in Interventional Cardiology: A Comprehensive Approach to Care for Older Adults: JACC Family Series JACC Cardiovasc. Inte. (IF 11.3) Pub Date : 2024-04-08 Abdulla A. Damluji MD PhD, Michael G. Nanna MD MHS, Jennifer Rymer MD MHS, Ajar Kochar MD MHA, Angela Lowenstern MD, Suzanne J. Baron MD, Craig R. Narins MD, Mohamad Alkhouli MD
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Transcatheter Edge-to-Edge Repair of Mitral Regurgitation: A Mature Technique JACC Cardiovasc. Inte. (IF 11.3) Pub Date : 2024-04-08 Erwan Donal MD PhD, Louis Gegout MD, Guillaume Leurent MD, K. Charlotte Lee BS
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New Approaches to Assessment and Management of Tricuspid Regurgitation Before Intervention JACC Cardiovasc. Inte. (IF 11.3) Pub Date : 2024-04-08 Garrett A. Welle MD, Rebecca T. Hahn MD, Joann Lindenfeld MD, Grace Lin MD, Vuyisile T. Nkomo MD, Jörg Hausleiter MD, Philipp C. Lurz MD, Sorin V. Pislaru MD, Charles J. Davidson MD, Mackram F. Eleid MD
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Transcatheter Mitral Valve Replacement for Valve-in-Ring: Innovative or Palliative Procedure? JACC Cardiovasc. Inte. (IF 11.3) Pub Date : 2024-04-08 Paul Guedeney MD PhD, Olivier Barthelemy MD, Gilles Montalescot MD PhD
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Coronary Physiology and Intravascular Imaging: When 2 Is Better Than 1 JACC Cardiovasc. Inte. (IF 11.3) Pub Date : 2024-04-08 Francesco Burzotta MD PhD, Carlo Trani MD
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Defining the Sweet Spot in Transcatheter Tricuspid Valve Interventions JACC Cardiovasc. Inte. (IF 11.3) Pub Date : 2024-04-08 Lorenzo Niro MD, Victoria Delgado MD PhD