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Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity JAMA (IF 63.1) Pub Date : 2024-09-19 Svetlana Mojsov
In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Svetlana Mojsov describes her discovery of GLP-1 (7-37), the biologically active incretin that led to development of effective GLP-1 analogues for treating diabetes and obesity.
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GLP-1 for Treating Obesity—Origin, History, and Evolution JAMA (IF 63.1) Pub Date : 2024-09-19 Lotte Bjerre Knudsen
In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Lotte Bjerre Knudsen describes her discovery of glucagon-like peptide-1 for the treatment of patients with obesity.
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Thirty-Five Years of HIV Research in Africa—An Interview With Winners of the 2024 Lasker-Bloomberg Public Service Award JAMA (IF 63.1) Pub Date : 2024-09-19 Preeti Malani
This Medical News article is an interview with Quarraisha Abdool Karim, PhD, and Salim S. Abdool Karim, MBChB, PhD, who received the award for their decades of work on AIDS in Africa.
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AIDS in Africa—Impact of Research JAMA (IF 63.1) Pub Date : 2024-09-19 Quarraisha Abdool Karim, Salim S. Abdool Karim
In this Viewpoint, 2024 Lasker-Bloomberg Public Service Award winners Quarraisha Abdool Karim and Salim S. Abdool Karim discuss their journey in AIDS research in South Africa and the local and global health impact of this research.
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siRNA therapy lowers triglycerides in patients with rare condition Nat. Med. (IF 58.7) Pub Date : 2024-09-19
Plozasiran reduced triglyceride levels by 80% and lowered the risk of pancreatitis in patients with persistent chylomicronemia, with or without a genetic diagnosis.
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Echocardiographic screening for heart failure and optimization of the care pathway for individuals with pacemakers: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2024-09-19 Maria F. Paton, John Gierula, Haqeel A. Jamil, Sam Straw, Judith E. Lowry, Rowena Byrom, Thomas A. Slater, Alasdair M. Fellows, Richard G. Gillott, Hemant Chumun, Paul Smith, Richard M. Cubbon, Deborah D. Stocken, Mark T. Kearney, Klaus K. Witte
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Newborn Screening and Presymptomatic Treatment of Metachromatic Leukodystrophy N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-18 Lucia Laugwitz University Hospital Tübingen, Tübingen, Germany, Thomas P. Mechtler ARCHIMEDlife Medical Laboratories, Vienna, Austria, Nils Janzen Screening Laboratory Hannover, Hannover, Germany, Petra Oliva ARCHIMEDlife Medical Laboratories, Vienna, Austria, Andrea-Romana Kasper Medical University of Vienna, Vienna, Austria, Charlotte E. Teunissen Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
In a pilot program in which 109,259 newborns were screened for metachromatic leukodystrophy, blood-spot samples were obtained for analysis and three newborns with MLD were identified, which made pr...
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Fabry’s Disease N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Stephen Soloway, and Denise Lister Arthritis and Rheumatology Associates of South Jersey, Vineland, NJ
A 44-year-old man presented with a 5-year history of heat intolerance and burning pain in his hands and feet. He had periumbilical angiokeratomas and nonnephrotic proteinuria. A kidney biopsy was p...
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House Staff Unionization — A Historical Tool Revisited N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Debra Malina, Ahmed Ahmed, and Scott H. Podolsky From the Department of Internal Medicine, Brigham and Women’s Hospital (A.A.), and the Department of Global Health and Social Medicine, Harvard Medical School (S.H.P.) — both in Boston.
As more and more U.S. residents unionize, examination of the history of house staff organizing highlights the enduring rationales for unionization, as well as the precipitating and resulting tensions.
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Targeting CSF1R in Chronic GVHD — Lessons in Translation N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Stefanie Sarantopoulos From the Division of Hematological Malignancies and Cellular Therapy, Duke University Department of Medicine, Department of Integrative Immunology, Duke Cancer Institute, Durham, NC.
Chronic graft-versus-host disease (GVHD) remains a rare and unacceptably debilitating autoimmune-like syndrome that afflicts patients in whom a blood disorder or cancer is otherwise cured by means ...
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Bending the Overdose Curve — Still Not Enough N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Daniel Ciccarone From Family and Community Medicine, University of California San Francisco, San Francisco.
The multiple waves of overdose deaths in the United States continue to morph in new and unexpected directions, now driven by fentanyl used in combination with other substances.1 Despite our public ...
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Two Clinical Trials Assessing Treatments for Eosinophilic Esophagitis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19
To the Editor: Chehade et al. (June 27 issue)1 explored the therapeutic effect of dupilumab in children with eosinophilic esophagitis. We have several concerns regarding the conclusions and methods...
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Noninvasive Ventilation for Preoxygenation during Emergency Intubation N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19
To the Editor: In their article regarding the Pragmatic Trial Examining Oxygenation Prior to Intubation (PREOXI), Gibbs et al. (June 20 issue)1 compared preoxygenation by means of either positive-p...
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Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Hanny Al-Samkari, Raj S. Kasthuri, Vivek N. Iyer, Allyson M. Pishko, Jake E. Decker, Clifford R. Weiss, Kevin J. Whitehead, Miles B. Conrad, Marc S. Zumberg, Jenny Y. Zhou, Joseph Parambil, Derek Marsh, Marianne Clancy, Lauren Bradley, Lisa Wisniewski, Benjamin A. Carper, Sonia M. Thomas, and Keith R. McCrae From Massachusetts General Hospital, Boston (H.A.-S.), University of North Carolina, Chapel
Hereditary hemorrhagic telangiectasia (HHT) is characterized by extensive telangiectasias and arteriovenous malformations. The primary clinical manifestation is epistaxis that results in iron-defic...
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Comparative effects of drug interventions for the acute management of migraine episodes in adults: systematic review and network meta-analysis BMJ (IF 93.6) Pub Date : 2024-09-18 William K Karlsson, Edoardo G Ostinelli, Zixuan A Zhuang, Lili Kokoti, Rune H Christensen, Haidar M Al-Khazali, Christina I Deligianni, Anneka Tomlinson, Håkan Ashina, Elena Ruiz de la Torre, Hans-Christoph Diener, Andrea Cipriani, Messoud Ashina
Objective To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults. Design Systematic review and network meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform, as well as websites of regulatory agencies
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Genitourinary syndrome of menopause … and other research BMJ (IF 93.6) Pub Date : 2024-09-19 Ann Robinson
Ann Robinson reviews the latest research Many women experience genitourinary symptoms during and after the menopause, but only in the past decade has the term genitourinary syndrome of menopause been used to describe the symptoms that result from falling oestrogen and androgen levels: dry vagina, painful and unfulfilling sex, low libido, urinary frequency, recurrent urinary tract infections, and labial
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Peter Cole: anaesthetist and researcher who highlighted the dangers of passive smoking years before it was considered a public health threat BMJ (IF 93.6) Pub Date : 2024-09-19 Anne Gulland
For Peter Cole, an anaesthetist at St Bartholomew’s Hospital in London, the life of a conventional hospital consultant would never have satisfied his intellectual curiosity. He had a busy brain and was keen to push scientific boundaries, and so alongside his clinical work he embarked on a long academic career—at a time when few anaesthetists were engaged in research. Described by Charles Hinds, one
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Tumour next to the internal urethral orifice BMJ (IF 93.6) Pub Date : 2024-09-19 Zhiwei Xie, Jizhou Shi
This image shows an inverted papilloma of the bladder, a rare benign tumour consisting of uniform urothelial cells with an inverted configuration and a normal or hyperplastic urothelial lining (fig 1).12 The patient, a …
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Gastroscopy findings . . . and other stories BMJ (IF 93.6) Pub Date : 2024-09-19 British Medical Journal Publishing Group
Analysis of the results of nearly 400 000 gastroscopies carried out in the UK for common gastrointestinal symptoms shows that only one in 10 reveals anything other than normal findings or minor pathology. The chances of finding cancer were greatest in older male patients, those over 50 with dysphagia, and those with weight loss in addition to symptoms, but the overall likelihood of diagnosis of malignancy
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Lecanemab’s benefits are too small and uncertain BMJ (IF 93.6) Pub Date : 2024-09-19 Robert Howard
Raised expectations of treatment effect do not justify the cost The UK Medicines and Healthcare products Regulatory Agency (MHRA) has approved the monoclonal antibody lecanemab for treatment of patients in the early stages of Alzheimer’s disease who have one or no copies of the apolipoprotein E4 (APOE4) gene.1 However, at the same time, the National Institute for Health and Care Excellence (NICE) issued
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Any NHS reform has to avoid a repeat of 2012 BMJ (IF 93.6) Pub Date : 2024-09-19 Tom Moberly
The BMA and the UK government have finally agreed about something—two things, in fact: a new pay deal and the need for major reform of the NHS. After 44 days of strike action over the past two years, resident doctors (as junior doctors will now be known) have voted to accept the government’s latest pay offer, with two thirds of those who voted backing the deal (doi:10.1136/bmj.q2038).1 The BMA and
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Reviewer acknowledgement 2024 CA: Cancer J. Clin. (IF 503.1) Pub Date : 2024-09-18
In order to maintain the high standards of CA’s content, the Editors of CA rely on the knowledge and dedication of many experts in deciding which topics to pursue, which manuscripts to publish, and what modifications to make to ensure medical and scientific accuracy and suitability for our readers. We thank our Associate Editors and our Editorial Advisory Board, who continue to provide these services
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Improving primary healthcare with generative AI Nat. Med. (IF 58.7) Pub Date : 2024-09-18 Winnie Yip
Studies in China show how large language models can improve primary healthcare systems, but equitably scaling this technology will require attention to rural, low-resource settings and the companion policies that support its implementation.
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Navigating treatment combinations in small-cell lung cancer Nat. Med. (IF 58.7) Pub Date : 2024-09-18 Ning Li, Si-Yu Wang
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Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region Nat. Med. (IF 58.7) Pub Date : 2024-09-18 Felipe Gomes Naveca, Tatiana Amaral Pires de Almeida, Victor Souza, Valdinete Nascimento, Dejanane Silva, Fernanda Nascimento, Matilde Mejía, Yasmin Silva de Oliveira, Luisa Rocha, Natana Xavier, Janis Lopes, Rodrigo Maito, Cátia Meneses, Tatyana Amorim, Luciana Fé, Fernanda Sindeaux Camelo, Samyly Coutinho de Aguiar Silva, Alexsandro Xavier de Melo, Leíse Gomes Fernandes, Marco Aurélio Almeida de
The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. Here, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia, and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current
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Countering the impact of the climate crisis on health will require data Nat. Med. (IF 58.7) Pub Date : 2024-09-17
As drastically rising global temperatures threaten the health and wellbeing of populations, solutions that drive policy action must be based on scientific evidence of which strategies work in different scenarios.
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Exposure to extreme heat increases perinatal mortality in sub-Saharan Africa Nat. Med. (IF 58.7) Pub Date : 2024-09-17
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Data-driven risk stratification and precision management of pulmonary nodules detected on chest computed tomography Nat. Med. (IF 58.7) Pub Date : 2024-09-17 Chengdi Wang, Jun Shao, Yichu He, Jiaojiao Wu, Xingting Liu, Liuqing Yang, Ying Wei, Xiang Sean Zhou, Yiqiang Zhan, Feng Shi, Dinggang Shen, Weimin Li
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The Darzi review distributes blame effectively BMJ (IF 93.6) Pub Date : 2024-09-17 Andy Cowper
Ara Darzi’s Independent Investigation of the NHS in England does two main things.1 Firstly, it tells attentive health experts nothing they didn’t already know about the dreadful present state of the English NHS. It contains no surprises. Secondly, it’s very much about allocating blame for how the English NHS got into that state. Both of these were needed. Since the end of the covid pandemic, NHS England’s
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Scarlett McNally: Building healthy habits for the new academic year BMJ (IF 93.6) Pub Date : 2024-09-18 Scarlett McNally
I love the new academic year. It’s full of possibilities and new routines. I experienced 20 consecutive years of my children’s new priorities and schedules beginning in September, and it still seems a much bigger deal to me than the new year in January. I went back to the school gates for this new term to see Eastbourne’s first “School Street”1—a scheme where motorised traffic is banned from the adjacent
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Alison Mary Brind: liver disease specialist and ultra marathon runner BMJ (IF 93.6) Pub Date : 2024-09-18 Anne Gulland
brind20240916.f1 In the months before she died Alison Brind self-published a book called I Never Stop , detailing her many sporting exploits. In the introduction she wrote, “I never stop and will only stop when I can do nothing.” As a mantra, “I never stop” summed up Brind’s attitude to life perfectly. The consultant hepatologist spent barely any time at home—instead she was to be found either pounding
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Darzi’s NHS review shows depth of problems for Labour BMJ (IF 93.6) Pub Date : 2024-09-18 Hugh Alderwick, Phoebe Dunn
Findings may buy time but highlight government policy tensions Ara Darzi’s independent review into the performance of the NHS in England, commissioned soon after Labour’s election victory in July 2024, was published on 12 September.1 The idea was to provide a rapid assessment of the state of the health system—focusing on problems, not solutions. Darzi’s findings are intended to inform the government’s
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New treatments for migraine … and other research BMJ (IF 93.6) Pub Date : 2024-09-18 British Medical Journal Publishing Group
In this research review by Tom Nolan ( BMJ 2024;386:q1967, …
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The Science of Biosimilars—Updating Interchangeability JAMA (IF 63.1) Pub Date : 2024-09-18 Patrizia Cavazzoni, Sarah Yim
This Viewpoint from the US Food and Drug Administration (FDA) summarizes a recent update to an FDA draft interchangeability guidance regarding the need for clinical switching studies to illustrate the FDA’s ongoing efforts to streamline the development of biosimilar medications that are in line with the latest science.
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The Patent Trial and Appeals Board JAMA (IF 63.1) Pub Date : 2024-09-18 Janet Freilich, Aaron S. Kesselheim
This Viewpoint summarizes the role of the Patent Trial and Appeal Board (PTAB) in reforming the drug patent process to avoid erroneously granted patents; highlights how other reform efforts, such as the PREVAIL Act, actually weaken the PTAB; and suggests changes to strengthen the PTAB and promote generic availability and reduced health care costs.
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Word Choice and the Patient Encounter JAMA (IF 63.1) Pub Date : 2024-09-18 Jeffrey D. Robinson, Douglas J. Opel
This JAMA Insights in the Communicating Medicine series explores how differences in word choice can affect both visit interactions and visit outcomes in patient encounters.
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The Crucial Role of Rapid Point-of-Care Tests for Malaria in Improving Fever Management. JAMA (IF 63.1) Pub Date : 2024-09-18 Osondu Ogbuoji,Wendy Prudhomme O'Meara
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Characteristics and Trends of Prehospital Encounters for Opioid Overdoses Among US Youth, 2018-2022 JAMA (IF 63.1) Pub Date : 2024-09-18 Jamie K. Lim, Sriram Ramgopal, Jennifer A. Hoffmann, Doug Lorenz, Michael S. Toce
This cross-sectional study analyzes characteristics of prehospital encounters for youth opioid overdoses and trends before and during the COVID-19 pandemic.
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Malaria Rapid Tests, Febrile Illness Management, and Child Mortality Across Sub-Saharan African Countries JAMA (IF 63.1) Pub Date : 2024-09-18 Han Zhang, Günther Fink, Jessica Cohen
ImportanceA prompt malaria diagnosis is crucial for the management of children with febrile illness in sub-Saharan African countries, where malaria remains a leading cause of mortality among children younger than 5 years of age. The development and distribution of point-of-care rapid diagnostic tests (RDTs) for malaria has transformed practice, but limited systematic evidence exists on how malaria
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Preschool-age children maintain a distinct memory CD4 + T cell and memory B cell response after SARS-CoV-2 infection Sci. Transl. Med. (IF 15.8) Pub Date : 2024-09-18 Benoît Manfroi, Bui Thi Cuc, Aurélien Sokal, Alexis Vandenberghe, Sarah Temmam, Mikaël Attia, Mohamed El Behi, Francesco Camaglia, Ngan Thu Nguyen, Jelka Pohar, Layale Salem-Wehbe, Valentine Pottez-Jouatte, Sibyline Borzakian, Narcisse Elenga, Caroline Galeotti, Guillaume Morelle, Camille de truchis de Lays, Michaela Semeraro, Anne-Sophie Romain, Mélodie Aubart, Naim Ouldali, Florence Mahuteau-Betzer
The development of the human immune system lasts for several years after birth. The impact of this maturation phase on the quality of adaptive immunity and the acquisition of immunological memory after infection at a young age remains incompletely defined. Here, using an antigen-reactive T cell (ARTE) assay and multidimensional flow cytometry, we profiled circulating severe acute respiratory syndrome
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Perfusion imaging metrics after acute traumatic spinal cord injury are associated with injury severity in rats and humans Sci. Transl. Med. (IF 15.8) Pub Date : 2024-09-18 Zin Z. Khaing, Jannik Leyendecker, Jennifer N. Harmon, Sananthan Sivakanthan, Lindsay N. Cates, Jeffrey E. Hyde, Melissa Krueger, Robb W. Glenny, Matthew Bruce, Christoph P. Hofstetter
Traumatic spinal cord injury (tSCI) causes an immediate loss of neurological function, and the prediction of recovery is difficult in the acute phase. In this study, we used contrast-enhanced ultrasound imaging to quantify intraspinal vascular disruption acutely after tSCI. In a rodent thoracic tSCI model, contrast-enhanced ultrasound revealed a perfusion area deficit that was positively correlated
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Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade Sci. Transl. Med. (IF 15.8) Pub Date : 2024-09-18 Justin C. Jagodinsky, Jessica M. Vera, Won Jong Jin, Amanda G. Shea, Paul A. Clark, Raghava N. Sriramaneni, Thomas C. Havighurst, Ishan Chakravarthy, Raad H. Allawi, KyungMann Kim, Paul M. Harari, Paul M. Sondel, Michael A. Newton, Marka R. Crittenden, Michael J. Gough, Jessica R. Miller, Irene M. Ong, Zachary S. Morris
Radiation therapy (RT) activates multiple immunologic effects in the tumor microenvironment (TME), with diverse dose-response relationships observed. We hypothesized that, in contrast with homogeneous RT, a heterogeneous RT dose would simultaneously optimize activation of multiple immunogenic effects in a single TME, resulting in a more effective antitumor immune response. Using high-dose-rate brachytherapy
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A deep intronic splice–altering AIRE variant causes APECED syndrome through antisense oligonucleotide-targetable pseudoexon inclusion Sci. Transl. Med. (IF 15.8) Pub Date : 2024-09-18 Sebastian Ochoa, Amy P. Hsu, Andrew J. Oler, Dhaneshwar Kumar, Daniel Chauss, Jan Piet van Hamburg, Gustaaf G. van Laar, Vasileios Oikonomou, Sundar Ganesan, Elise M. N. Ferré, Monica M. Schmitt, Tom DiMaggio, Princess Barber, Gregory M. Constantine, Lindsey B. Rosen, Paul G. Auwaerter, Bhumika Gandhi, Jennifer L. Miller, Rachel Eisenberg, Arye Rubinstein, Edith Schussler, Erjola Balliu, Vandana Shashi
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a life-threatening monogenic autoimmune disorder primarily caused by biallelic deleterious variants in the autoimmune regulator ( AIRE ) gene. We prospectively evaluated 104 patients with clinically diagnosed APECED syndrome and identified 17 patients (16%) from 14 kindreds lacking biallelic AIRE variants in exons or flanking
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Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis Sci. Transl. Med. (IF 15.8) Pub Date : 2024-09-18 Anushka Saha, Trirupa Chakraborty, Javad Rahimikollu, Hanxi Xiao, Lorena B. Pereira de Oliveira, Timothy W. Hand, Sukwan Handali, W. Evan Secor, Lucia A. O. Fraga, Jessica K. Fairley, Jishnu Das, Aniruddh Sarkar
Schistosomiasis, a highly prevalent parasitic disease, affects more than 200 million people worldwide. Current diagnostics based on parasite egg detection in stool detect infection only at a late stage, and current antibody-based tests cannot distinguish past from current infection. Here, we developed and used a multiplexed antibody profiling platform to obtain a comprehensive repertoire of antihelminth
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ARGX-119 is an agonist antibody for human MuSK that reverses disease relapse in a mouse model of congenital myasthenic syndrome Sci. Transl. Med. (IF 15.8) Pub Date : 2024-09-18 Roeland Vanhauwaert, Julien Oury, Bernhardt Vankerckhoven, Christophe Steyaert, Stine Marie Jensen, Dana L. E. Vergoossen, Christa Kneip, Leah Santana, Jamie L. Lim, Jaap J. Plomp, Roy Augustinus, Shohei Koide, Christophe Blanchetot, Peter Ulrichts, Maartje G. Huijbers, Karen Silence, Steven J. Burden
Muscle-specific kinase (MuSK) is essential for the formation, function, and preservation of neuromuscular synapses. Activation of MuSK by a MuSK agonist antibody may stabilize or improve the function of the neuromuscular junction (NMJ) in patients with disorders of the NMJ, such as congenital myasthenia (CM). Here, we generated and characterized ARGX-119, a first-in-class humanized agonist monoclonal
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The importance of the day of embryo transfer during in vitro fertilisation BMJ (IF 93.6) Pub Date : 2024-09-16 Simone Cornelisse, Liliana Ramos, Sebastiaan Mastenbroek
The timing of embryo transfer, which aligns with different stages of embryo development, is an important element of in vitro fertilisation (IVF). This article briefly describes the main phases of IVF treatment, embryo development and transfer policies, cumulative live birth rates, and the key findings of the authors’ research. In vitro fertilisation (IVF) is a well established treatment for infertility
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Cumulative live birth rate of a blastocyst versus cleavage stage embryo transfer policy during in vitro fertilisation in women with a good prognosis: multicentre randomised controlled trial BMJ (IF 93.6) Pub Date : 2024-09-16 Simone Cornelisse, Kathrin Fleischer, Lucette van der Westerlaken, Jan-Peter de Bruin, Carlijn Vergouw, Carolien Koks, Josien Derhaag, Jantien Visser, Jannie van Echten-Arends, Els Slappendel, Brigitte Arends, Moniek van der Zanden, Angelique van Dongen, Janneke Brink-van der Vlugt, Marcella de Hundt, Max Curfs, Harold Verhoeve, Maaike Traas-Hofmans, Yvonne Wurth, Petra Manger, Quirine Pieterse, Didi
Objectives To evaluate whether embryo transfers at blastocyst stage improve the cumulative live birth rate after oocyte retrieval, including both fresh and frozen-thawed transfers, and whether the risk of obstetric and perinatal complications is increased compared with cleavage stage embryo transfers during in vitro fertilisation (IVF) treatment. Design Multicentre randomised controlled trial. Setting
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Acute aortic syndrome BMJ (IF 93.6) Pub Date : 2024-09-17 Steve Goodacre, Valerie Lechene, Graham Cooper, Sarah Wilson, Jim Zhong
### What you need to know A healthy woman in her mid 50s experiences sudden, tearing pain, like a lightning bolt from her neck to her chest, radiating to her back, coming in waves, with severity fluctuating over subsequent hours. At times she is able to talk and even walk, but she feels that her consciousness level is mostly reduced, and she has difficulty breathing. She feels dizzy and nauseous. Her
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Helen Salisbury: Getting the best out of general practice BMJ (IF 93.6) Pub Date : 2024-09-17 Helen Salisbury
What would a more productive general practice look like? Of course, it’s hard to measure productivity when your job is mostly about preventing things from happening. If you’re a surgeon, you can count the number of operations completed (although variations in complexity will mean that a simple number isn’t an accurate reflection of the work done)—but if most of your role is to keep people well and
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Matt Morgan: Pods and wards—flipping through rotations BMJ (IF 93.6) Pub Date : 2024-09-17 Matt Morgan
Some readers may remember Kathy. She filled my childhood Sunday afternoons as the main character in my favourite television show. She wasn’t a doctor; she wasn’t even a human. Kathy was an intelligent dolphin who helped solve local crimes like an underwater version of Lassie , in the 1960s series Flipper . But Kathy’s story had a difficult end because of the isolated, captive environment she lived
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Medical students face enough pressures—the “academic weapon” trend doesn’t help BMJ (IF 93.6) Pub Date : 2024-09-17 Diana Dovgy
The celebration of extreme study habits encourages an unhealthy attitude to learning and success, writes Diana Dovgy The term “academic weapon” went viral around two years ago, when a video on TikTok showed a university student sitting in the front row of a 700 person lecture.1 He shared that the key to acing the semester was to become an “absolute academic weapon,” which in his eyes meant approaching
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Guy Ah-Moye: London GP who led reform of health services in his native Seychelles BMJ (IF 93.6) Pub Date : 2024-09-17 Tim Bullamore
When Guy Ah-Moye returned to his native Seychelles in 1970 after medical studies in London, he sailed on the British India ship with his trusty bicycle. On embarking, wearing nothing but shorts, he rode straight to the home of his friend Marcel Fayon, the local tennis champion, with both legs in the air and shouting with joy: “Sove ma kraz zote (Save yourself, I’ll crash into you)!” Delight at returning
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Barriers to investigating and reporting research misconduct: prioritising publication integrity BMJ (IF 93.6) Pub Date : 2024-09-16 Alison Avenell, Andrew A Klein, Jennifer A Byrne, Peter Wilmshurst, Mark J Bolland, Andrew Grey
Bouter’s editorial1 on the UK Research Integrity Office (UKRIO) report Barriers to investigating and reporting research misconduct 2 highlights protecting patients from consequences of research misconduct. Waiting for publishers to correct publications affected by misconduct or errors can take years. In the meantime, these papers influence clinical guidelines and patient care. Delays have been so concerning
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Non-steroidal anti-inflammatory drugs may disrupt muscle and tissue repair BMJ (IF 93.6) Pub Date : 2024-09-17 Edoardo Cervoni
Camacho and colleagues’ study highlights the economic and health impacts of high risk non-steroidal anti-inflammatory drug (NSAID) use.1 I would like to draw attention to the effects of NSAIDs on muscle and connective tissue repair, which is pertinent to the study. NSAIDs are widely used to manage pain …
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Doctor suicide: “All I could see were tasks mounting, appointments being booked, and people constantly knocking on my door” BMJ (IF 93.6) Pub Date : 2024-09-17 Adele Waters
A recent report has set out recommendations that could prevent doctors from taking their own lives. Adele Waters speaks to doctors and families touched by suicide Sarah Jacques remembers the day she came close to killing herself. The 46 year old former GP from Battle, East Sussex, says she “just snapped” one day at work, drove to the seafront, parked her car, and got out to watch the sea. She stayed
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Timing embryo transfers during assisted reproduction BMJ (IF 93.6) Pub Date : 2024-09-16 Demián Glujovsky
New evidence will help women and clinicians navigate this difficult decision In assisted reproductive technology, the timing of embryo transfer after oocyte retrieval and in vitro fertilisation is crucial. Traditionally, embryos have been transferred at the cleavage stage (two or three days post-fertilisation). However, transferring embryos at the blastocyst stage (five or six days post-fertilisation)
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Management of atrial fibrillation in older adults BMJ (IF 93.6) Pub Date : 2024-09-17 Anna L Parks, David S Frankel, Dae H Kim, Darae Ko, Daniel B Kramer, Melis Lydston, Margaret C Fang, Sachin J Shah
Most people with atrial fibrillation are older adults, in whom atrial fibrillation co-occurs with other chronic conditions, polypharmacy, and geriatric syndromes such as frailty. Yet most randomized controlled trials and expert guidelines use an age agnostic approach. Given the heterogeneity of aging, these data may not be universally applicable across the spectrum of older adults. This review synthesizes
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Junior doctors in England accept pay deal worth 22% over two years. BMJ (IF 93.6) Pub Date : 2024-09-17 Gareth Iacobucci
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Valproate: Sanofi ordered to pay €285 000 to mother whose children had birth defects. BMJ (IF 93.6) Pub Date : 2024-09-17 Barbara Casassus
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Peer review practices are "delaying science," academic claims in lawsuit against six publishers. BMJ (IF 93.6) Pub Date : 2024-09-17 Clare Dyer