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Risk Factors for Immune Checkpoint Inhibitor-Induced Diabetes Identified. JAMA (IF 63.1) Pub Date : 2024-09-20 Samantha Anderer
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Hormone Therapy Associated With Slower Biological Aging in Menopause. JAMA (IF 63.1) Pub Date : 2024-09-20 Samantha Anderer
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What to Know About the Recent Rise in Parvovirus B19 Infections. JAMA (IF 63.1) Pub Date : 2024-09-20 Rita Rubin
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WHO Announces Mpox Global Plan, Appeals for Funding. JAMA (IF 63.1) Pub Date : 2024-09-20 Samantha Anderer
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HHS Dedicates Millions to Expand Prenatal, Postpartum Home Visits. JAMA (IF 63.1) Pub Date : 2024-09-20 Samantha Anderer
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Study: Heat-Related Deaths on the Rise in US Since 2016. JAMA (IF 63.1) Pub Date : 2024-09-20 Samantha Anderer
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FDA Approves First Automated Insulin Device for Type 2 Diabetes. JAMA (IF 63.1) Pub Date : 2024-09-20 Samantha Anderer
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A 485-million-year history of Earth's surface temperature. Science (IF 44.7) Pub Date : 2024-09-20 Emily J Judd,Jessica E Tierney,Daniel J Lunt,Isabel P Montañez,Brian T Huber,Scott L Wing,Paul J Valdes
A long-term record of global mean surface temperature (GMST) provides critical insight into the dynamical limits of Earth's climate and the complex feedbacks between temperature and the broader Earth system. Here, we present PhanDA, a reconstruction of GMST over the past 485 million years, generated by statistically integrating proxy data with climate model simulations. PhanDA exhibits a large range
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Germline mutations in a G protein identify signaling cross-talk in T cells. Science (IF 44.7) Pub Date : 2024-09-20 Hyoungjun Ham,Huie Jing,Ian T Lamborn,Megan M Kober,Alexey Koval,Yamina A Berchiche,D Eric Anderson,Kirk M Druey,Judith N Mandl,Bertrand Isidor,Carlos R Ferreira,Alexandra F Freeman,Sundar Ganesan,Meliha Karsak,Peter J Mustillo,Juliana Teo,Zarazuela Zolkipli-Cunningham,Nicolas Chatron,François Lecoquierre,Andrew J Oler,Jana Pachlopnik Schmid,Douglas B Kuhns,Xuehua Xu,Fabian Hauck,Waleed Al-Herz,Matias
Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in GNAI2, which encodes Gαi2, a key component in heterotrimeric G protein signal transduction usually thought to regulate adenylyl cyclase-mediated cyclic adenosine monophosphate (cAMP) production. Patients with activating Gαi2 mutations had
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Large library docking identifies positive allosteric modulators of the calcium-sensing receptor. Science (IF 44.7) Pub Date : 2024-09-20 Fangyu Liu,Cheng-Guo Wu,Chia-Ling Tu,Isabella Glenn,Justin Meyerowitz,Anat Levit Kaplan,Jiankun Lyu,Zhiqiang Cheng,Olga O Tarkhanova,Yurii S Moroz,John J Irwin,Wenhan Chang,Brian K Shoichet,Georgios Skiniotis
Positive allosteric modulator (PAM) drugs enhance the activation of the calcium-sensing receptor (CaSR) and suppress parathyroid hormone (PTH) secretion. Unfortunately, these hyperparathyroidism-treating drugs can induce hypocalcemia and arrhythmias. Seeking improved modulators, we docked libraries of 2.7 million and 1.2 billion molecules against the CaSR structure. The billion-molecule docking found
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Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity JAMA (IF 63.1) Pub Date : 2024-09-19 Svetlana Mojsov
In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Svetlana Mojsov describes her discovery of GLP-1 (7-37), the biologically active incretin that led to development of effective GLP-1 analogues for treating diabetes and obesity.
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GLP-1 for Treating Obesity—Origin, History, and Evolution JAMA (IF 63.1) Pub Date : 2024-09-19 Lotte Bjerre Knudsen
In this Viewpoint, 2024 Lasker-DeBakey Clinical Medical Research Award winner Lotte Bjerre Knudsen describes her discovery of glucagon-like peptide-1 for the treatment of patients with obesity.
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Thirty-Five Years of HIV Research in Africa—An Interview With Winners of the 2024 Lasker-Bloomberg Public Service Award JAMA (IF 63.1) Pub Date : 2024-09-19 Preeti Malani
This Medical News article is an interview with Quarraisha Abdool Karim, PhD, and Salim S. Abdool Karim, MBChB, PhD, who received the award for their decades of work on AIDS in Africa.
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AIDS in Africa—Impact of Research JAMA (IF 63.1) Pub Date : 2024-09-19 Quarraisha Abdool Karim, Salim S. Abdool Karim
In this Viewpoint, 2024 Lasker-Bloomberg Public Service Award winners Quarraisha Abdool Karim and Salim S. Abdool Karim discuss their journey in AIDS research in South Africa and the local and global health impact of this research.
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siRNA therapy lowers triglycerides in patients with rare condition Nat. Med. (IF 58.7) Pub Date : 2024-09-19
Plozasiran reduced triglyceride levels by 80% and lowered the risk of pancreatitis in patients with persistent chylomicronemia, with or without a genetic diagnosis.
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Echocardiographic screening for heart failure and optimization of the care pathway for individuals with pacemakers: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2024-09-19 Maria F. Paton, John Gierula, Haqeel A. Jamil, Sam Straw, Judith E. Lowry, Rowena Byrom, Thomas A. Slater, Alasdair M. Fellows, Richard G. Gillott, Hemant Chumun, Paul Smith, Richard M. Cubbon, Deborah D. Stocken, Mark T. Kearney, Klaus K. Witte
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How studying octopus nurseries can shape the future of our oceans Nature (IF 50.5) Pub Date : 2024-09-19
Beth Orcutt wants to learn more about life at the bottom of the ocean, to inform decision-making on deep sea mining.
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Obesity-drug pioneers win prestigious Lasker Award for medical science Nature (IF 50.5) Pub Date : 2024-09-19
Three scientists are honoured for developing a class of blockbuster weight-loss drugs. Is a Nobel prize on the way?
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What does peak emissions mean for China — and the world? Nature (IF 50.5) Pub Date : 2024-09-19
The milestone is essential for slowing global warming, but the hard work is still to come.
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Tackling the reality of noma Nature (IF 50.5) Pub Date : 2024-09-19
The severe disease of the face has finally been recognized as a neglected tropical disease. A heightened focus could help to unravel the mystery of what causes it.
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A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS Nature (IF 50.5) Pub Date : 2024-09-18 Borja Ocón, Menglan Xiang, Yuhan Bi, Serena Tan, Kevin Brulois, Aiman Ayesha, Manali Kunte, Catherine Zhou, Melissa LaJevic, Nicole Lazarus, Francesca Mengoni, Tanya Sharma, Stephen Montgomery, Jody E. Hooper, Mian Huang, Tracy Handel, John R. D. Dawson, Irina Kufareva, Brian A. Zabel, Junliang Pan, Eugene C. Butcher
Tissue-selective chemoattractants direct lymphocytes to epithelial surfaces to establish local immune environments, regulate immune responses to food antigens and commensal organisms, and protect from pathogens. Homeostatic chemoattractants for small intestines, colon, and skin are known1 2, but chemotropic mechanisms selective for respiratory tract and other non-intestinal mucosal tissues (NIMT) remain
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Colossal 'jets' shooting from a black hole defy physicists' theories Nature (IF 50.5) Pub Date : 2024-09-18
Hear the biggest stories from the world of science | 18 September 2024
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Advanced CMOS manufacturing of superconducting qubits on 300 mm wafers Nature (IF 50.5) Pub Date : 2024-09-18 J. Van Damme, S. Massar, R. Acharya, Ts. Ivanov, D. Perez Lozano, Y. Canvel, M. Demarets, D. Vangoidsenhoven, Y. Hermans, J. G. Lai, A. M. Vadiraj, M. Mongillo, D. Wan, J. De Boeck, A. Potočnik, K. De Greve
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Opto-twistronic Hall effect in a three-dimensional spiral lattice Nature (IF 50.5) Pub Date : 2024-09-18 Zhurun Ji, Yuzhou Zhao, Yicong Chen, Ziyan Zhu, Yuhui Wang, Wenjing Liu, Gaurav Modi, Eugene J. Mele, Song Jin, Ritesh Agarwal
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Commensal consortia decolonize Enterobacteriaceae via ecological control Nature (IF 50.5) Pub Date : 2024-09-18 Munehiro Furuichi, Takaaki Kawaguchi, Marie-Madlen Pust, Keiko Yasuma-Mitobe, Damian R. Plichta, Naomi Hasegawa, Takashi Ohya, Shakti K. Bhattarai, Satoshi Sasajima, Yoshimasa Aoto, Timur Tuganbaev, Mizuki Yaginuma, Masahiro Ueda, Nobuyuki Okahashi, Kimiko Amafuji, Yuko Kiridoshi, Kayoko Sugita, Martin Stražar, Julian Avila-Pacheco, Kerry Pierce, Clary B. Clish, Ashwin N. Skelly, Masahira Hattori,
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One step from oxides to sustainable bulk alloys Nature (IF 50.5) Pub Date : 2024-09-18 Shaolou Wei, Yan Ma, Dierk Raabe
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Temporal BMP4 effects on mouse embryonic and extraembryonic development Nature (IF 50.5) Pub Date : 2024-09-18 Ron Hadas, Hernan Rubinstein, Markus Mittnenzweig, Yoav Mayshar, Raz Ben-Yair, Saifeng Cheng, Alejandro Aguilera-Castrejon, Netta Reines, Ayelet-Hashahar Orenbuch, Aviezer Lifshitz, Dong-Yuan Chen, Michael B. Elowitz, Magdalena Zernicka-Goetz, Jacob H. Hanna, Amos Tanay, Yonatan Stelzer
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Two-factor authentication underpins the precision of the piRNA pathway Nature (IF 50.5) Pub Date : 2024-09-18 Madeleine Dias Mirandela, Ansgar Zoch, Jessica Leismann, Shaun Webb, Rebecca V. Berrens, Devisree Valsakumar, Yuka Kabayama, Tania Auchynnikava, Martina Schito, Tamoghna Chowdhury, David MacLeod, Xinyu Xiang, Juan Zou, Juri Rappsilber, Robin C. Allshire, Philipp Voigt, Atlanta G. Cook, Joan Barau, Dónal O’Carroll
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Controlled patterning of crystalline domains by frontal polymerization Nature (IF 50.5) Pub Date : 2024-09-18 Justine E. Paul, Yuan Gao, Yoo Kyung Go, Luis E. Rodriguez Koett, Anisha Sharma, Manxin Chen, Jacob J. Lessard, Tolga Topkaya, Cecilia Leal, Jeffrey S. Moore, Philippe H. Geubelle, Nancy R. Sottos
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Observation of quantum entanglement with top quarks at the ATLAS detector Nature (IF 50.5) Pub Date : 2024-09-18
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Mars’s induced magnetosphere can degenerate Nature (IF 50.5) Pub Date : 2024-09-18 Qi Zhang, Stas Barabash, Mats Holmstrom, Xiao-dong Wang, Yoshifumi Futaana, Christopher M. Fowler, Robin Ramstad, Hans Nilsson
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Black hole jets on the scale of the cosmic web Nature (IF 50.5) Pub Date : 2024-09-18 Martijn S. S. L. Oei, Martin J. Hardcastle, Roland Timmerman, Aivin R. D. J. G. I. B. Gast, Andrea Botteon, Antonio C. Rodriguez, Daniel Stern, Gabriela Calistro Rivera, Reinout J. van Weeren, Huub J. A. Röttgering, Huib T. Intema, Francesco de Gasperin, S. G. Djorgovski
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Three-dimensional wave breaking Nature (IF 50.5) Pub Date : 2024-09-18 M. L. McAllister, S. Draycott, R. Calvert, T. Davey, F. Dias, T. S. van den Bremer
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Micronuclear battery based on a coalescent energy transducer Nature (IF 50.5) Pub Date : 2024-09-18 Kai Li, Congchong Yan, Junren Wang, Kun Zhu, Junjun Guo, Yugang Zhang, Guozheng Shi, Yuchen Yin, Liwei Cheng, Liang Sun, Yumin Wang, Hailong Zhang, Ying Sun, Jianyu Yuan, Wanli Ma, Guoxun Ji, Zhifang Chai, Yaxing Wang, Xiaoping Ouyang, Shuao Wang
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Endogenous opioid signalling regulates spinal ependymal cell proliferation Nature (IF 50.5) Pub Date : 2024-09-18 Wendy W. S. Yue, Kouki K. Touhara, Kenichi Toma, Xin Duan, David Julius
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Targeted protein relocalization via protein transport coupling Nature (IF 50.5) Pub Date : 2024-09-18 Christine S. C. Ng, Aofei Liu, Bianxiao Cui, Steven M. Banik
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Dynamic transition and Galilean relativity of current-driven skyrmions Nature (IF 50.5) Pub Date : 2024-09-18 Max T. Birch, Ilya Belopolski, Yukako Fujishiro, Minoru Kawamura, Akiko Kikkawa, Yasujiro Taguchi, Max Hirschberger, Naoto Nagaosa, Yoshinori Tokura
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Observation-constrained projections reveal longer-than-expected dry spells Nature (IF 50.5) Pub Date : 2024-09-18 Irina Y. Petrova, Diego G. Miralles, Florent Brient, Markus G. Donat, Seung-Ki Min, Yeon-Hee Kim, Margot Bador
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Pathogenic hypothalamic extracellular matrix promotes metabolic disease Nature (IF 50.5) Pub Date : 2024-09-18 Cait A. Beddows, Feiyue Shi, Anna L. Horton, Sagar Dalal, Ping Zhang, Chang-Chun Ling, V. Wee Yong, Kim Loh, Ellie Cho, Chris Karagiannis, Adam J. Rose, Magdalene K. Montgomery, Paul Gregorevic, Matthew J. Watt, Nicolle H. Packer, Benjamin L. Parker, Robyn M. Brown, Edward S. X. Moh, Garron T. Dodd
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Space radiation measurements during the Artemis I lunar mission Nature (IF 50.5) Pub Date : 2024-09-18 Stuart P. George, Ramona Gaza, Daniel Matthiä, Diego Laramore, Jussi Lehti, Thomas Campbell-Ricketts, Martin Kroupa, Nicholas Stoffle, Karel Marsalek, Bartos Przybyla, Mena Abdelmelek, Joachim Aeckerlein, Amir A. Bahadori, Janet Barzilla, Matthias Dieckmann, Michael Ecord, Ricky Egeland, Timo Eronen, Dan Fry, Bailey H. Jones, Christine E. Hellweg, Jordan Houri, Robert Hirsh, Mika Hirvonen, Scott Hovland
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Quarks show that quantum entanglement holds at high energies Nature (IF 50.5) Pub Date : 2024-09-18 Martin Hentschinski
Proton–proton collisions confirm quantum principle in top-quark pairs.
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Daily briefing: Crustaceans can ‘smell’ their way back to their home cave Nature (IF 50.5) Pub Date : 2024-09-18
Tiny crustaceans can detect their home waters using ‘smell’. Plus, the challenges that accompany the cure for sickle-cell disease.
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Small molecules help misplaced proteins hitchhike around cells Nature (IF 50.5) Pub Date : 2024-09-18 Robert Yvon, Christina M. Woo
Proteins induced to shuttle between the nucleus and cytoplasm.
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Magnetic whirlpools creep and flow in response to emergent electrodynamics Nature (IF 50.5) Pub Date : 2024-09-18 Yingying Wu
Dynamic behaviours in a skyrmion-hosting material.
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Brain goop that traps hunger neurons drives obesity Nature (IF 50.5) Pub Date : 2024-09-18
A mechanism for metabolic disease is traced to a defective cellular scaffolding that holds together the brain’s hunger cells.
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Crosstalk between the embryo and the developing placenta relies on same signal for multiple messages Nature (IF 50.5) Pub Date : 2024-09-18
Proper communication between embryonic tissues is crucial to the production of the correct balance of cell types.
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Gut microbes fend off harmful bacteria by depriving them of nutrients Nature (IF 50.5) Pub Date : 2024-09-18 Eric G. Pamer
Depletion of the molecule gluconate halts gut colonization by a pathogen.
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CERN prepares to expel Russian scientists — but won’t completely cut ties Nature (IF 50.5) Pub Date : 2024-09-18
The laboratory has ended its agreement with the nation, but will continue working with a Russian nuclear-research institute, raising tensions among researchers.
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Obesity is driven by a build-up of molecular mesh around hunger neurons Nature (IF 50.5) Pub Date : 2024-09-18 Alexander Dityatev
Neuronal insulin resistance caused by excess extracellular matrix.
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Quantum feat: physicists observe entangled quarks for first time Nature (IF 50.5) Pub Date : 2024-09-18
Particle measurements at the Large Hadron Collider open the door to future high-energy tests of entanglement.
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Black holes as big as atoms might be speeding through the Solar System Nature (IF 50.5) Pub Date : 2024-09-17
Primordial black holes, which are smaller than their better-known cousins, visit the inner Solar System once a decade, simulations suggest.
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Newborn Screening and Presymptomatic Treatment of Metachromatic Leukodystrophy N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-18 Lucia Laugwitz University Hospital Tübingen, Tübingen, Germany, Thomas P. Mechtler ARCHIMEDlife Medical Laboratories, Vienna, Austria, Nils Janzen Screening Laboratory Hannover, Hannover, Germany, Petra Oliva ARCHIMEDlife Medical Laboratories, Vienna, Austria, Andrea-Romana Kasper Medical University of Vienna, Vienna, Austria, Charlotte E. Teunissen Vrije Universiteit Amsterdam, Amsterdam, the Netherlands
In a pilot program in which 109,259 newborns were screened for metachromatic leukodystrophy, blood-spot samples were obtained for analysis and three newborns with MLD were identified, which made pr...
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Fabry’s Disease N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Stephen Soloway, and Denise Lister Arthritis and Rheumatology Associates of South Jersey, Vineland, NJ
A 44-year-old man presented with a 5-year history of heat intolerance and burning pain in his hands and feet. He had periumbilical angiokeratomas and nonnephrotic proteinuria. A kidney biopsy was p...
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House Staff Unionization — A Historical Tool Revisited N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Debra Malina, Ahmed Ahmed, and Scott H. Podolsky From the Department of Internal Medicine, Brigham and Women’s Hospital (A.A.), and the Department of Global Health and Social Medicine, Harvard Medical School (S.H.P.) — both in Boston.
As more and more U.S. residents unionize, examination of the history of house staff organizing highlights the enduring rationales for unionization, as well as the precipitating and resulting tensions.
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Targeting CSF1R in Chronic GVHD — Lessons in Translation N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Stefanie Sarantopoulos From the Division of Hematological Malignancies and Cellular Therapy, Duke University Department of Medicine, Department of Integrative Immunology, Duke Cancer Institute, Durham, NC.
Chronic graft-versus-host disease (GVHD) remains a rare and unacceptably debilitating autoimmune-like syndrome that afflicts patients in whom a blood disorder or cancer is otherwise cured by means ...
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Bending the Overdose Curve — Still Not Enough N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Daniel Ciccarone From Family and Community Medicine, University of California San Francisco, San Francisco.
The multiple waves of overdose deaths in the United States continue to morph in new and unexpected directions, now driven by fentanyl used in combination with other substances.1 Despite our public ...
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Two Clinical Trials Assessing Treatments for Eosinophilic Esophagitis N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19
To the Editor: Chehade et al. (June 27 issue)1 explored the therapeutic effect of dupilumab in children with eosinophilic esophagitis. We have several concerns regarding the conclusions and methods...
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Noninvasive Ventilation for Preoxygenation during Emergency Intubation N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19
To the Editor: In their article regarding the Pragmatic Trial Examining Oxygenation Prior to Intubation (PREOXI), Gibbs et al. (June 20 issue)1 compared preoxygenation by means of either positive-p...
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Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia N. Engl. J. Med. (IF 96.2) Pub Date : 2024-09-19 Hanny Al-Samkari, Raj S. Kasthuri, Vivek N. Iyer, Allyson M. Pishko, Jake E. Decker, Clifford R. Weiss, Kevin J. Whitehead, Miles B. Conrad, Marc S. Zumberg, Jenny Y. Zhou, Joseph Parambil, Derek Marsh, Marianne Clancy, Lauren Bradley, Lisa Wisniewski, Benjamin A. Carper, Sonia M. Thomas, and Keith R. McCrae From Massachusetts General Hospital, Boston (H.A.-S.), University of North Carolina, Chapel
Hereditary hemorrhagic telangiectasia (HHT) is characterized by extensive telangiectasias and arteriovenous malformations. The primary clinical manifestation is epistaxis that results in iron-defic...
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Comparative effects of drug interventions for the acute management of migraine episodes in adults: systematic review and network meta-analysis BMJ (IF 93.6) Pub Date : 2024-09-18 William K Karlsson, Edoardo G Ostinelli, Zixuan A Zhuang, Lili Kokoti, Rune H Christensen, Haidar M Al-Khazali, Christina I Deligianni, Anneka Tomlinson, Håkan Ashina, Elena Ruiz de la Torre, Hans-Christoph Diener, Andrea Cipriani, Messoud Ashina
Objective To compare all licensed drug interventions as oral monotherapy for the acute treatment of migraine episodes in adults. Design Systematic review and network meta-analysis. Data sources Cochrane Central Register of Controlled Trials, Medline, Embase, ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Platform, as well as websites of regulatory agencies