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Morning Glory Syndrome in a Newborn Aged 2 Weeks JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Francesco Pozzo Giuffrida, Marco Nassisi, Silvia Osnaghi
This case report describes a diagnosis of morning glory syndrome in a 2-week-old infant who presented with divergent strabismus, cleft lip, and hypertelorism.
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Facial Swelling After External Dacryocystorhinostomy JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Tyler Herod, Rami Darwich, Ahsen Hussain
A 67-year-old woman underwent elective external dacryocystorhinostomy to treat symptomatic nasolacrimal duct obstruction and developed persistent cervicofacial swelling and ecchymoses of the eyelids and cheek. Head computed tomography revealed extensive emphysema throughout the soft tissues of the face and neck. What would you do next?
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Oral Sirolimus for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Amy Kalantary, Anne Halbert, Maria Franchina, Rachael C. Heath Jeffery, Rod O’Day, Fred K. Chen
This case report describes an 8-year-old girl who received oral sirolimus as an adjuvant therapy for pulse dye laser of her port-wine stain and as an off-label treatment of exudative retinal detachment secondary to diffuse choroidal hemangioma.
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Patching in Children With Unilateral Congenital Cataract and Child Functioning and Parenting Stress JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-18 Carolyn Drews-Botsch, George Cotsonis, Marianne Celano, E. Eugenie Hartmann, Jaffer Zaidi, Scott R. Lambert
ImportanceParents may be concerned about the adverse outcomes of occlusion therapy in children treated for unilateral congenital cataract (UCC).ObjectiveTo determine whether occlusion therapy in children treated for UCC with poor visual outcomes is negatively associated with poorer child and/or family functioning.Design, Setting, and ParticipantsThis cohort study was conducted in 2023 using data collected
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Access to Pediatric Eye Care by Practitioner Type, Geographic Distribution, and US Population Demographics JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-11 Nora E. Siegler, Hannah L. Walsh, Kara M. Cavuoto
ImportanceInvestigating disparities in service coverage of pediatric optometrists and pediatric ophthalmologists in relation to patient demographics will illuminate vulnerable populations and inform future interventions.ObjectiveTo characterize the geographic distribution of pediatric eye care practitioners and analyze its association with population demographics.Design, Setting, and ParticipantsIn
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Digital Technology Use Among Older Adults With Vision Impairment JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Jonathan Thomas, Louay Almidani, Bonnielin K. Swenor, Varshini Varadaraj
ImportanceTelehealth has the potential to improve health for older adults, but many access disparities exist, including for those with vision impairment (VI).ObjectiveTo examine the associations between VI and digital technology access measures in US older adults.Design, Setting, and ParticipantsThis was a cross-sectional study that included Medicare beneficiaries 65 years and older. Beneficiary data
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Postoperative Inflammation After Anterior Segment Surgery JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Matthew Schulgit, Danny A. Mammo, Sunil K. Srivastava
A 71-year-old woman had 2 months of worsening vision and pain in her right eye. Examination revealed retrocorneal plaque, peaking of the pupil, and temporal prominent scleral vessels with inferotemporal scleral thinning. What would you do next?
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Mental Health Conditions Associated With Strabismus in a Diverse Cohort of US Adults JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-04-04 Kimberly Jin, Inas F. Aboobakar, Mary C. Whitman, Isdin Oke
ImportanceGreater understanding of the association between strabismus and mental health conditions across sociodemographic backgrounds may inform strategies to improve mental well-being in this population.ObjectiveTo describe the association of strabismus with mental health conditions in a diverse cohort of US adults.Design, Setting, and ParticipantsThis cross-sectional study used data from the National
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Sudden Vision Loss JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-28 Archana A. Nair, Meredith E. Pugh, Edward F. Cherney
A 37-year-old woman was referred for evaluation of a retinal detachment in her left eye. Posterior examination results demonstrated a retinal detachment in the posterior pole with shifting fluid and no identifiable retinal break, and there was a thickened choroid with a hyporeflective band on ultrasound biomicroscopy. What would you do next?
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Bias Reduction Practices in Underrepresented Groups in Ophthalmology Resident Recruitment JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-28 Ogul E. Uner, Dongseok Choi, Thomas S. Hwang, Ambar Faridi
ImportanceBest recruitment practices for increasing diversity are well established, but the adoption and impact of these practices in ophthalmology residency recruitment are unknown.ObjectiveTo describe the adoption of bias reduction practices in groups underrepresented in ophthalmology (URiO) residency recruitment and determine which practices are effective for increasing URiO residents.Design, Setting
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Genetic Associations of Primary Angle-Closure Disease JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-28 Yu Jing Liang, Yu Yao Wang, Shi Song Rong, Zhen Ji Chen, Shu Ying Chen, Jenson A. Tham, Poemen P. Chan, Jason C. Yam, Janey L. Wiggs, Chi Pui Pang, Clement C. Tham, Li Jia Chen
ImportanceEffects of genetic variants on primary angle-closure disease remained uncertain.ObjectiveTo systematically review the associations of common single-nucleotide variants (SNVs) and rare coding variants with primary angle-closure disease, its subtypes (including primary angle-closure glaucoma, primary angle-closure suspect, and primary angle-closure) and progression.Data SourcesEligible studies
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Association of Occlusive Retinal Vasculitis With Intravitreal Faricimab JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-22 Ye Li, Robert Chong, Adrian T. Fung
This case report describes a patient with attenuation of retinal arterioles and veins associated with 2 blot hemorrhages and pallor of the inferotemporal retina without emboli.
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Laser in Situ Keratomileusis Flap Free-Floating on Interface Edema in Acute Corneal Hydrops JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Evan J. Warner
This case report describes a patient with a history of laser in situ keratomileusis who presented with pain, photophobia, and blurred vision secondary to a corneal flap free-floating on interface edema in the setting of acute hydrops.
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Clinical Features and Treatment Outcomes of Carbapenem-Resistant Pseudomonas aeruginosa Keratitis JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Felipe Echeverri Tribin, Caroline Lieux, Jorge Maestre-Mesa, Heather Durkee, Katherine Krishna, Brandon Chou, Emily Neag, Jana D’Amato Tóthová, Jaime D. Martinez, Harry W. Flynn, Jean Marie Parel, Darlene Miller, Guillermo Amescua
ImportanceEvaluation of the microbiological diagnostic profile of multidrug-resistant Pseudomonas aeruginosa keratitis and potential management with rose bengal–photodynamic antimicrobial therapy (RB-PDAT) is important.ObjectiveTo document the disease progression of carbapenemase-resistant P aeruginosa keratitis after an artificial tear contamination outbreak.Design, Setting, and ParticipantsThis retrospective
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Multifocal Unilateral Orange Fundus Tumors in a Young Man JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Bibhav Poudel, Vijitha S. Vempuluru, Carol L. Shields
A 38-year-old man had an asymptomatic, orange, macular choroidal mass with macular choroidal folds and a retinal pigment epithelial detachment in the right eye and a second orange mass nasal to the optic disc also in the right eye. What would you do next?
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Dystrophic Calcification in a 3-Piece Silicone Intraocular Lens JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Anvesh Annadanam, Boonkit Purt
This case report describes a diagnosis of dystrophic calcification of a silicone intraocular lens implant in a patient who presented with foggy vision and glare.
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Human Whole-Eye Donation for Research—Optimizing Clinical Trial Informed Consent JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Katrina A. Bramstedt
ImportancePosthumous whole-eye (globe) donations for research lack a mechanism that reinvolves the existing ophthalmic research team of the donor unless there is a preplanned donor directive. Disconnection between the deceased and their research team equates to lost opportunities for the research team to have a longitudinal view of the eyes that have been involved in their research.ObjectivesTo use
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Corneal Plug Keratoplasty for the Treatment of Small Corneal Perforation JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-21 Xiaolin Qi, Hua Gao
This case report describes the performance of corneal plug keratoplasty in a male patient aged 30 years who presented with corneal perforation secondary to metal foreign body.
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Phase 2 Trial Evaluating Minocycline for Geographic Atrophy in Age-Related Macular Degeneration JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-14 Tiarnan D. L. Keenan, Clare Bailey, Maria Abraham, Christine Orndahl, Supriya Menezes, Sunil Bellur, Thilaka Arunachalam, Cathy Kangale-Whitney, Sowmya Srinivas, Ayesha Karamat, Muneeswar Nittala, Denise Cunningham, Brett G. Jeffrey, Henry E. Wiley, Alisa T. Thavikulwat, SriniVas Sadda, Catherine A. Cukras, Emily Y. Chew, Wai T. Wong
ImportanceExisting therapies to slow geographic atrophy (GA) enlargement in age-related macular degeneration (AMD) have relatively modest anatomic efficacy, require intravitreal administration, and increase the risk of neovascular AMD. Additional therapeutic approaches are desirable.ObjectiveTo evaluate the safety and possible anatomic efficacy of oral minocycline, a microglial inhibitor, for the treatment
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Polygenic Risk Scores for Glaucoma Onset in the Ocular Hypertension Treatment Study JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-14 Rishabh K. Singh, Yan Zhao, Tobias Elze, John Fingert, Mae Gordon, Michael A. Kass, Yuyang Luo, Louis R. Pasquale, Todd Scheetz, Ayellet V. Segrè, Janey L. Wiggs, Nazlee Zebardast
ImportancePrimary open-angle glaucoma (POAG) is a highly heritable disease, with 127 identified risk loci to date. Polygenic risk score (PRS) may provide a clinically useful measure of aggregate genetic burden and improve patient risk stratification.ObjectiveTo assess whether a PRS improves prediction of POAG onset in patients with ocular hypertension.Design, Setting, and ParticipantsThis was a post
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Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-07 Kyoko Ohno-Matsui, Tae Igarashi-Yokoi, Takeshi Azuma, Keigo Sugisawa, Jianping Xiong, Tomonari Takahashi, Kengo Uramoto, Koju Kamoi, Michiaki Okamoto, Suchandra Banerjee, Masahiro Yamanari
ImportanceThe relevance of visualizing scleral fiber orientation may offer insights into the pathogenesis of pathologic myopia, including dome-shaped maculopathy (DSM).ObjectiveTo investigate the orientation and density of scleral collagen fibers in highly myopic eyes with and without DSM by polarization-sensitive optical coherence tomography (PS-OCT).Design, Setting, and ParticipantsThis case series
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Multinational External Validation of Autonomous Retinopathy of Prematurity Screening JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-07 Aaron S. Coyner, Tom Murickan, Minn A. Oh, Benjamin K. Young, Susan R. Ostmo, Praveer Singh, R. V. Paul Chan, Darius M. Moshfeghi, Parag K. Shah, Narendran Venkatapathy, Michael F. Chiang, Jayashree Kalpathy-Cramer, J. Peter Campbell
ImportanceRetinopathy of prematurity (ROP) is a leading cause of blindness in children, with significant disparities in outcomes between high-income and low-income countries, due in part to insufficient access to ROP screening.ObjectiveTo evaluate how well autonomous artificial intelligence (AI)–based ROP screening can detect more-than-mild ROP (mtmROP) and type 1 ROP.Design, Setting, and ParticipantsThis
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Water-Free Cyclosporine Ophthalmic Solution vs Vehicle for Dry Eye Disease JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-07 Rongmei Peng, Ying Jie, Qin Long, Lan Gong, Lei Zhu, Xingwu Zhong, Shaozhen Zhao, Xiaoming Yan, Hao Gu, Huping Wu, Gang Li, Kaiyun Zhang, Sonja Krösser, Ruxia Xu, Jing Hong
ImportanceDry eye disease (DED) is a prevalent eye disorder. Cyclosporine is an effective immunomodulator that is widely used in DED; however, due to its highly hydrophobic nature, delivery of cyclosporine to the ocular surface is challenging.ObjectiveTo evaluate the efficacy and safety of SHR8028, a water-free cyclosporine ophthalmic solution, 0.1%, compared with vehicle in Chinese participants with
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A Case of a Bumpy Retina JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-03-07 Sidra Zafar, Anthony Gonzales, Sophie Cai
A 77-year-old male had 3 months of progressive vision decline in the left eye. Dilated fundus examination revealed diffuse hyperpigmented lesions involving the macula and superior fundus that corresponded to areas of nodular retinal pigment epithelium thickening on optical coherence tomography. What would you do next?
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A Suspicious Pigmented Lesion of the Conjunctiva JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-29 Karla Murillo, Kaela Acuff, Nathan L. Scott
A 74-year-old woman with a history of breast cancer, now in remission, presented for evaluation of a conjunctival lesion of the right eye. What would you do next?
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ATXN7-Related Cone-Rod Dystrophy JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-29 Marco Nassisi, Giulia Coarelli, Benoit Blanchard, Charlotte Dubec-Fleury, Karima Drine, Nicolas Kitic, Serge Sancho, Rania Hilab, Sophie Tezenas du Montcel, Candice Junge, Roger Lane, H. Moore Arnold, Alexandra Durr, Isabelle Audo
ImportanceReliable biomarkers with diagnostic and prognostic values are needed for upcoming gene therapy trials for spinocerebellar ataxias.ObjectiveTo identify ophthalmological biomarkers in a sample of spinocerebellar ataxia type 7 (SCA7) carriers.Design, Setting, and ParticipantsThis article presents baseline data from a cross-sectional natural history study conducted in Paris, France, reference
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Severe Intraocular Inflammation Following Intravitreal Faricimab JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-29 Loka Thangamathesvaran, Jun Kong, Susan B. Bressler, Mandeep Singh, Adam S. Wenick, Adrienne W. Scott, J. Fernando Arévalo, Neil M. Bressler
ImportanceMonitoring for and reporting potential cases of intraocular inflammation (IOI) in clinical practice despite limited occurrences in clinical trials, including experiences with relatively new intravitreal agents, such as brolucizumab, pegcetacoplan, or faricimab, helps balance potential benefits and risks of these agents.ObjectiveTo provide descriptions of 3 initially culture-negative cases
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Accuracy of an Artificial Intelligence Chatbot’s Interpretation of Clinical Ophthalmic Images JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-29 Andrew Mihalache, Ryan S. Huang, Marko M. Popovic, Nikhil S. Patil, Bhadra U. Pandya, Reut Shor, Austin Pereira, Jason M. Kwok, Peng Yan, David T. Wong, Peter J. Kertes, Rajeev H. Muni
ImportanceOphthalmology is reliant on effective interpretation of multimodal imaging to ensure diagnostic accuracy. The new ability of ChatGPT-4 (OpenAI) to interpret ophthalmic images has not yet been explored.ObjectiveTo evaluate the performance of the novel release of an artificial intelligence chatbot that is capable of processing imaging data.Design, Setting, and ParticipantsThis cross-sectional
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Vision Impairment and Psychosocial Function in US Adults JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-22 Louay Almidani, Rhonda Miller, Varshini Varadaraj, Aleksandra Mihailovic, Bonnielin K. Swenor, Pradeep Y. Ramulu
ImportanceVision impairment and psychosocial function, including symptoms of depression and anxiety and social isolation, are a major cause of morbidity in the US. However, there is a lack of nationally representative studies assessing associations between both objective and subjective vision impairment with psychosocial function following the COVID-19 pandemic.ObjectiveTo provide updated national
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Maculopathy in a 52-Year-Old Patient With Diabetes JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-22 Alexander Kwok, Carson Ercanbrack, Sami Uwaydat
A 52-year-old woman with severe nonproliferative diabetic retinopathy had decreased vision and macular edema in both eyes that was not responding to treatment. What would you do next?
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Assessment of a Large Language Model’s Responses to Questions and Cases About Glaucoma and Retina Management JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-22 Andy S. Huang, Kyle Hirabayashi, Laura Barna, Deep Parikh, Louis R. Pasquale
ImportanceLarge language models (LLMs) are revolutionizing medical diagnosis and treatment, offering unprecedented accuracy and ease surpassing conventional search engines. Their integration into medical assistance programs will become pivotal for ophthalmologists as an adjunct for practicing evidence-based medicine. Therefore, the diagnostic and treatment accuracy of LLM-generated responses compared
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Presence of Copy Number Variants Associated With Esotropia in Patients With Exotropia JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-15 Mayra Martinez Sanchez, Wai-Man Chan, Sarah E. MacKinnon, Brenda Barry, David G. Hunter, Elizabeth C. Engle, Mary C. Whitman
ImportanceStrabismus is a common ocular disorder of childhood. There is a clear genetic component to strabismus, but it is not known if esotropia and exotropia share genetic risk factors.ObjectiveTo determine whether genetic duplications associated with esotropia are also associated with exotropia.Design, Setting, and ParticipantsThis was a cross-sectional study conducted from November 2005 to December
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Risk of Herpes Zoster Ophthalmicus Recurrence After Recombinant Zoster Vaccination JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-15 Anushka Walia, Yuwei Sun, Nisha R. Acharya
ImportanceThe recombinant zoster vaccine (RZV) is currently recommended for immunocompetent adults aged 50 years or older and immunocompromised adults aged 19 years or older and is effective in preventing herpes zoster ophthalmicus (HZO). However, questions about the safety of RZV in patients with a history of HZO remain.ObjectiveTo evaluate whether there is an increased risk of HZO recurrence after
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Bilateral Blurry Vision After a Liver Transplant JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-15 Wenjia Cai, Xin Chen, Xiaohu Ding
A 31-year-old woman presented for evaluation of bilateral blurry vision over the past month. She experienced fulminant hepatic failure 3 months ago and underwent a liver transplant 2 weeks later. Postoperative pathological results showed hepatolenticular degeneration. What would you do next?
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Resolution of Crystalline Retinopathy After Kidney Transplant for Hyperoxaluria JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-15 Lauren C. Kiryakoza, Jesse D. Sengillo, Audina M. Berrocal
This case report discusses the evolution of crystalline retinopathy secondary to systemic hyperoxalosis after kidney transplant for hyperoxaluria was performed.
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Central Retinal Artery Occlusion With Cilioretinal Artery Sparing JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-15 Nitin Menia, Arun Kapil, Reema Bansal
This case report describes a diagnosis of central retinal artery occlusion in a patient in their early 30s who presented with decreased vision in the left eye for 1 week.
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Cystic-Appearing Eyelid Lesion in a 62-Year-Old Man JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-08 Yilin Feng, Carolina A. Chiou, Natalie Wolkow
A 62-year-old male was referred for evaluation of a painless right lower-eyelid lesion noted during routine glaucoma follow-up. The lesion had been present for 3 years with slow, gradual enlargement. What would you do next?
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Visual Impairment and Real-World Home Physical Activity With Home Environment in an Older Population JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-08 Seema Banerjee, Aleksandra Mihailovic, Rhonda Miller, Jian-Yu E, Laura N. Gitlin, Yingzi Xiong, Sheila West, David S. Friedman, Pradeep Y. Ramulu
ImportancePhysical activity levels are lower in visual impairment. However, additional factors, such as home environmental features, which can modify physical activity in this group, are unknown.ObjectiveTo investigate the association between home environment features and home physical activity in patients with visual impairment.Design, Setting, and ParticipantsThis cross-sectional study of clinical
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Automated Machine Learning for Predicting Diabetic Retinopathy Progression From Ultra-Widefield Retinal Images JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-08 Paolo S. Silva, Dean Zhang, Cris Martin P. Jacoba, Ward Fickweiler, Drew Lewis, Jeremy Leitmeyer, Katie Curran, Recivall P. Salongcay, Duy Doan, Mohamed Ashraf, Jerry D. Cavallerano, Jennifer K. Sun, Tunde Peto, Lloyd Paul Aiello
ImportanceMachine learning (ML) algorithms have the potential to identify eyes with early diabetic retinopathy (DR) at increased risk for disease progression.ObjectiveTo create and validate automated ML models (autoML) for DR progression from ultra-widefield (UWF) retinal images.Design, Setting and ParticipantsDeidentified UWF images with mild or moderate nonproliferative DR (NPDR) with 3 years of
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Sociodemographic and Clinical Predictors of Prolonged Length of Corneal Ulcer Hospitalizations JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-08 Sinan Akosman, Renxi Li, Bryan Kwon, William West, Masumi Asahi, Keith J. Wroblewski
ImportanceThe length of stay (LOS) of hospitalizations may be a useful indicator of the burden of disease of corneal ulcers. Identifying variables associated with longer LOS may help to enhance delivery of care for high-risk patients.ObjectiveTo investigate the sociodemographic, social, and clinical factors associated with LOS in hospitalizations for corneal ulcers in the US.Design, Setting, and ParticipantsThis
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Diabetic Retinopathy and Quality of Life JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-01 Mohammed G. Zayed, Waseem Karsan, Tunde Peto, Ponnusamy Saravanan, Gianni Virgili, David Preiss
ImportanceThe association between diabetic retinopathy (DR) and quality of life (QoL) has not been thoroughly investigated.ObjectiveTo investigate the association between DR and both vision-related QoL (VRQoL) and general health-related QoL (HRQoL).Data SourcesMEDLINE, EBSCO, Embase, and Web of Science were searched from their inception to April 2022.Study SelectionStudies included adults with DR and
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Amblyopia Care Trends Following Widespread Photoscreener Adoption JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-01 Cheryl D. Stults, Su-Ying Liang, Joseph Wilcox, Omondi L. Nyong’o
ImportanceAmblyopia can result in permanent vision loss if not properly treated before age 7 years. In 2017, the US Preventive Services Task Force recommended that vision screening should occur at least once in all children aged 3 to 5 years to detect amblyopia.ObjectiveTo understand trends and factors associated with screening, referral, or diagnosis of amblyopia before and after photoscreening expansion
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Circulating Tumor DNA Posttreatment Measurements and Clinical Correlates in Retinoblastoma JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-01 David H. Abramson, Melissa A. Robbins, Y. Pierre Gobin, Ira J. Dunkel, Jasmine H. Francis
ImportancePlasma measurements of RB1 circulating tumor DNA (ctDNA) after completion of treatment may be associated with the development of metastases in patients with retinoblastoma.ObjectiveTo determine if the absence of previously detectable plasma ctDNA is associated with metastasis-free survival in patients with a minimum of 1 year follow-up after treatment of retinoblastoma.Design, Setting, and
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An Atypical Optic Nerve Head Mass JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-02-01 Michael J. Maywood, Viren K. Govindaraju, Tedi Begaj
A 47-year-old man presented with a sudden decrease in vision in the right eye and a history of binocular diplopia, bilateral cranial nerve 6 palsies, and an undifferentiated pontine mass. Examination revealed a large optic nerve head mass with optic disc hyperemia, scattered dot hemorrhages, a placoid lesion in the posterior pole, and a mass protruding out of the optic nerve head. What would you do
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Four-Year Progression of Myopic Maculopathy in Children and Adolescents With High Myopia JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-25 Feng Jiang, Decai Wang, Ou Xiao, Xinxing Guo, Qiuxia Yin, Lixia Luo, Mingguang He, Zhixi Li
ImportanceIndividuals with high myopia younger than 18 years are at relatively high risk of progressively worsening myopic maculopathy. Additional studies are needed to investigate the progression of myopic maculopathy in this age group, as well as the risk factors associated with progression.ObjectiveTo investigate the 4-year progression of myopic maculopathy in children and adolescents with high
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Older Woman With Proptosis, Ptosis, and Blurred Vision JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-25 Alison B. Gibbons, Charles Eberhart, Emily Li
A woman in her early 70s with a history of coronary artery disease, hypertension, and colon polyps presented to oculoplastic surgery with 1 week of progressive right-sided proptosis, headache, right eyelid ptosis, and blurry vision. Outside magnetic resonance imaging demonstrated an infiltrative mass involving right greater than left orbital apices, the right optic nerve, and right extraocular muscles
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Retinopathy Associated With Coxsackie B Virus Infection JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-18 Adam Hanif, Aristomenis Thanos
This case report describes a diagnosis of unilateral retinopathy secondary to coxsackie B virus in a male patient aged 41 years who presented with a central scotoma and blistering rash of the hands, feet, and mouth for 4 days.
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Unilateral Diffuse Pigmentary Retinopathy Associated With Optic Disc Pit JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-18 Joseph Luvisi, Tinea Morris, Emil Say
This case report describes a diagnosis of pigmentary retinopathy and optic disc pit in a woman aged 41 years who presented with long-standing decreased vision in the left eye.
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Pigmented Squamous Cell Carcinoma In Situ of the Eyelid JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-18 Antonios D. Dimopoulos, Pooja Srivastava, Anne Barmettler
This case report describes a diagnosis of pigmented squamous cell carcinoma in situ in a female patient aged 61 years who presented with a pigmented lesion on her medial canthus that had been growing over a 2-year period.
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Sex Disparities in Ophthalmology From Training Through Practice JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-18 Nikki Rousta, Isra M. Hussein, Radha P. Kohly
ImportanceSex-based research in medicine has revealed inequities against females on almost every metric at almost every career stage; ophthalmology is no exception.ObjectiveTo systematically review the experiences of females in ophthalmology (FiO) from training through practice in high-income countries (HICs).Evidence ReviewA systematic review of English-language studies, published between January
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Long-Term Risk and Prediction of Progression in Primary Angle Closure Suspect JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-18 Yixiong Yuan, Ruilin Xiong, Wei Wang, Benjamin Y. Xu, Chimei Liao, Shaopeng Yang, Cong Li, Jian Zhang, Qiuxia Yin, Yingfeng Zheng, David S. Friedman, Paul J. Foster, Mingguang He
ImportanceIdentifying primary angle closure suspect (PACS) eyes at risk of angle closure is crucial for its management. However, the risk of progression and its prediction are still understudied in long-term longitudinal studies about PACS.ObjectiveTo explore baseline predictors and develop prediction models for the 14-year risk of progression from PACS to primary angle closure (PAC).Design, Setting
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Intra-Anterior Chamber Injection of Ranibizumab in Advanced Pediatric Vitreoretinal Diseases JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-18 Wenting Zhang, Huanyu Liu, Yiye Chen, Xuerui Zhang, Victoria Y. Gu, Haodong Xiao, Yuan Yang, Jiawei Yin, Jie Peng, Peiquan Zhao
ImportanceAnti–vascular endothelial growth factor (VEGF) treatment through intravitreal or subretinal administrations has been proven effective for VEGF-driven pediatric vitreoretinal diseases but are not feasible for advanced cases, such as shallow traction retinal detachments or peripheral circumferential retinal detachments which adhere to the lens. Intra-anterior chamber injection (IAcI) of anti-VEGF
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Sex or Gender Reporting in Ophthalmology Clinical Trials Among US Food and Drug Administration Approvals, 1995 to 2022 JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-18 Jim Shenchu Xie, Hargun Kaur, Brendan Tao, Jordon Lee, Danielle Solish, Radha Kohly, Edward Margolin
ImportanceAs critical determinants of scientific rigor, reproducibility, and equity, sex and gender should be considered in clinical trial design and reporting.ObjectiveTo evaluate the accuracy of sex and gender reporting and extent of sex- and gender-based analysis in clinical trials associated with US Food and Drug Administration (FDA) drug approvals between January 1, 1995, and December 31, 2022
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Epidermal Growth Factor Receptor Inhibitors for Lung Cancer and the Risk of Keratitis JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-11 Pin-Chia Huang, Ching-Chieh Lin, Reza Dana, Kevin Sheng-Kai Ma
ImportanceEpidermal growth factor receptor inhibitors (EGFRis) have been reported to be associated with cutaneous and ocular side effects; however, there is limited evidence of an association between EGFRi treatment and keratitis.ObjectiveTo determine the association between EGFRi treatment and agents and the risk of new-onset keratitis among patients with lung cancer.Design, Setting, and ParticipantsThis
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Green Space Morphology and School Myopia in China JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-04 Yahan Yang, Huipeng Liao, Lanqin Zhao, Xun Wang, XiaoWei Yang, Xiaohu Ding, Xuelong Li, Zhiyu Jiang, Xingying Zhang, Qingling Zhang, Huagui He, Liang Guo, Hualiang Lin, Guanghui Dong, Bryan Spencer, Mingguang He, Nathan Congdon, Ian George Morgan, Haotian Lin
ImportanceChina has experienced both rapid urbanization and major increases in myopia prevalence. Previous studies suggest that green space exposure reduces the risk of myopia, but the association between myopia risk and specific geometry and distribution characteristics of green space has yet to be explored. These must be understood to craft effective interventions to reduce myopia.ObjectiveTo evaluate
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Alzheimer Disease Treatment With Acetylcholinesterase Inhibitors and Incident Age-Related Macular Degeneration JAMA Ophthalmol. (IF 8.1) Pub Date : 2024-01-04 S. Scott Sutton, Joseph Magagnoli, Tammy H. Cummings, James W. Hardin, Jayakrishna Ambati
ImportanceAge-related macular degeneration (AMD) is a serious and common ophthalmologic disorder that is hypothesized to result, in part, from inflammatory reactions in the macula. Alzheimer disease (AD) treatment, acetylcholinesterase inhibitors (AChEIs), have anti-inflammatory effects and it remains unclear if they modify the risk of AMD.ObjectiveTo investigate the association between AChEI medications
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Metformin Use and Age-Related Macular Degeneration in Patients Without Diabetes. JAMA Ophthalmol. (IF 8.1) Pub Date : 2023-11-30 Sarthak Aggarwal,John Moir,Max J Hyman,Gabriel T Kaufmann,Andrea Flores,Seenu M Hariprasad,Dimitra Skondra
Importance Metformin use may protect against the development of age-related macular degeneration (AMD) based on results from observational studies. However, its potential effectiveness among patients without diabetes remains unclear. Objective To assess the association between metformin use and the development of AMD in patients without diabetes. Design, Setting, and Participants This case-control
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Sociodemographic Characteristics Distinguished From Social Determinants of Health. JAMA Ophthalmol. (IF 8.1) Pub Date : 2023-11-30 Katelin M Alfaro Hudak,Jinan Saaddine,David B Rein
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Atropine Eye Drops for Myopia Control in Childhood-More Long-Term Data, Please. JAMA Ophthalmol. (IF 8.1) Pub Date : 2023-11-30 Michael X Repka
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Topical Atropine for Childhood Myopia Control: The Atropine Treatment Long-Term Assessment Study. JAMA Ophthalmol. (IF 8.1) Pub Date : 2023-11-30 Yong Li,Michelle Yip,Yilin Ning,Joey Chung,Angeline Toh,Cheryl Leow,Nan Liu,Daniel Ting,Leopold Schmetterer,Seang-Mei Saw,Jost B Jonas,Audrey Chia,Marcus Ang
Importance Clinical trial results of topical atropine eye drops for childhood myopia control have shown inconsistent outcomes across short-term studies, with little long-term safety or other outcomes reported. Objective To report the long-term safety and outcomes of topical atropine for childhood myopia control. Design, Setting, and Participants This prospective, double-masked observational study of