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Prognostic Models for Mortality and Morbidity in Heart Failure With Preserved Ejection Fraction JAMA Cardiol. (IF 24.0) Pub Date : 2024-03-27 Kirsty McDowell, Toru Kondo, Atefeh Talebi, Ken Teh, Erasmus Bachus, Rudolf A. de Boer, Ross T. Campbell, Brian Claggett, Ashkay S. Desai, Kieran F. Docherty, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe Martinez, Joanne Simpson, Muthiah Vaduganathan, Pardeep S. Jhund, Scott D. Solomon, John J. V. McMurray
ImportanceAccurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions.ObjectiveTo develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach.Design, Setting,
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A Revised Definition of Left Bundle Branch Block Using Time to Notch in Lead I JAMA Cardiol. (IF 24.0) Pub Date : 2024-03-27 Jeremy S. Treger, Ahmad B. Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D. Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A. Upadhyay
ImportanceCurrent left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy.ObjectiveTo develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate
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Electrocardiographic Findings in Female Professional Basketball Athletes JAMA Cardiol. (IF 24.0) Pub Date : 2024-03-20 Bradley S. Lander, Eamon Y. Duffy, Jessica A. Hennessey, Sonia Tolani, Nidhi Patel, Michael S. Bohnen, Jeffrey J. Hsu, Alfred Danielian, Ankit B. Shah, Marci Goolsby, Matthew W. Martinez, Dermot Phelan, David J. Engel
ImportancePrevious studies of professional basketball athletes have characterized manifestations of athletic remodeling by echocardiography and electrocardiography (ECG) in males and echocardiography in females. There is a paucity of female, basketball-specific ECG data.ObjectiveTo generate reference range ECG data for female professional basketball athletes.Design, Setting, and ParticipantsThis is
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A Female in Her 50s With Caseating Mitral Annulus Calcification JAMA Cardiol. (IF 24.0) Pub Date : 2024-03-13 Iva Minga, Vinesh Appadurai, Vera Rigolin
This case report describes a diagnosis of caseating mitral annulus calcification in a female patient with a history of peritoneal dialysis who presented with confusion and disorientation.
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Deep Learning–Augmented ECG Analysis for Screening and Genotype Prediction of Congenital Long QT Syndrome JAMA Cardiol. (IF 24.0) Pub Date : 2024-03-06 River Jiang, Christopher C. Cheung, Marta Garcia-Montero, Brianna Davies, Jason Cao, Damian Redfearn, Zachary M. Laksman, Steffany Grondin, Joseph Atallah, Carolina A. Escudero, Julia Cadrin-Tourigny, Shubhayan Sanatani, Christian Steinberg, Jacqueline Joza, Robert Avram, Rafik Tadros, Andrew D. Krahn
ImportanceCongenital long QT syndrome (LQTS) is associated with syncope, ventricular arrhythmias, and sudden death. Half of patients with LQTS have a normal or borderline-normal QT interval despite LQTS often being detected by QT prolongation on resting electrocardiography (ECG).ObjectiveTo develop a deep learning–based neural network for identification of LQTS and differentiation of genotypes (LQTS1
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Cardiopulmonary Exercise Testing in Evaluating Transthyretin Amyloidosis JAMA Cardiol. (IF 24.0) Pub Date : 2024-03-06 Rishi K. Patel, Francesco Bandera, Lucia Venneri, Aldostefano Porcari, Yousuf Razvi, Adam Ioannou, Liza Chacko, Ana Martinez-Naharro, Muhammad U. Rauf, Daniel Knight, James Brown, Aviva Petrie, Ashutosh Wechalekar, Carol Whelan, Helen Lachmann, Vivek Muthurangu, Marco Guazzi, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana
ImportanceCardiopulmonary exercise testing (CPET) has an established role in the assessment of patients with heart failure. However, data are lacking in patients with transthyretin (ATTR) amyloidosis.ObjectiveTo use CPET to characterize the spectrum of functional phenotypes in patients with ATTR amyloidosis and assess their association with the cardiac amyloid burden as well as the association between
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Novel Polygenic Risk Score and Established Clinical Risk Factors for Risk Estimation of Aortic Stenosis JAMA Cardiol. (IF 24.0) Pub Date : 2024-02-28 Aeron M. Small, Giorgio E. M. Melloni, Frederick K. Kamanu, Brian A. Bergmark, Marc P. Bonaca, Michelle L. O’Donoghue, Robert P. Giugliano, Benjamin M. Scirica, Deepak Bhatt, Elliott M. Antman, Itamar Raz, Stephen D. Wiviott, Buu Truong, Peter W. F. Wilson, Kelly Cho, Christopher J. O’Donnell, Eugene Braunwald, Steve A. Lubitz, Patrick Ellinor, Gina M. Peloso, Christian T. Ruff, Marc S. Sabatine, Pradeep
ImportancePolygenic risk scores (PRSs) have proven to be as strong as or stronger than established clinical risk factors for many cardiovascular phenotypes. Whether this is true for aortic stenosis remains unknown.ObjectiveTo develop a novel aortic stenosis PRS and compare its aortic stenosis risk estimation to established clinical risk factors.Design, Setting, and ParticipantsThis was a longitudinal
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Accelerometer-Measured Physical Activity, Sedentary Time, and Heart Failure Risk in Women Aged 63 to 99 Years JAMA Cardiol. (IF 24.0) Pub Date : 2024-02-21 Michael J. LaMonte, Andrea Z. LaCroix, Steve Nguyen, Kelly R. Evenson, Chongzhi Di, Marcia L. Stefanick, Eric T. Hyde, Blake Anuskiewicz, Charles B. Eaton
ImportanceHeart failure (HF) prevention is paramount to public health in the 21st century.ObjectiveTo examine incident HF and its subtypes with preserved ejection fraction (HFpEF) and reduced EF (HFrEF) according to accelerometer-measured physical activity (PA) and sedentary time.Design, Setting, and ParticipantsThis was a prospective cohort study, the Objective Physical Activity and Cardiovascular
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Interventions for Optimization of Guideline-Directed Medical Therapy JAMA Cardiol. (IF 24.0) Pub Date : 2024-02-21 Amber B. Tang, Nicholas K. Brownell, Jacob S. Roberts, Amier Haidar, Antonia Osuna-Garcia, David J. Cho, Pooya Bokhoor, Gregg C. Fonarow
ImportanceImplementation of guideline-directed medical therapy (GDMT) in real-world practice remains suboptimal. It is unclear which interventions are most effective at addressing current barriers to GDMT in patients with heart failure with reduced ejection fraction (HFrEF).ObjectiveTo perform a systematic review to identify which types of system-level initiatives are most effective at improving GDMT
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Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations JAMA Cardiol. (IF 24.0) Pub Date : 2024-02-14 Aeron M. Small, Ashley Pournamdari, Giorgio E.M. Melloni, Benjamin M. Scirica, Deepak L. Bhatt, Itamar Raz, Eugene Braunwald, Robert P. Giugliano, Marc S. Sabatine, Gina M. Peloso, Nicholas A. Marston, Pradeep Natarajan
ImportanceElevated lipoprotein(a) (Lp[a]) is a putative causal risk factor for atherosclerotic cardiovascular disease (ASCVD). There are conflicting data as to whether Lp(a) may increase cardiovascular risk only in the presence of concomitant inflammation.ObjectiveTo investigate whether Lp(a) is associated with cardiovascular risk independent of high-sensitivity C-reactive protein (hs-CRP) in both
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β-Blocker Withdrawal and Functional Capacity Improvement in Patients With Heart Failure With Preserved Ejection Fraction JAMA Cardiol. (IF 24.0) Pub Date : 2024-02-07 Patricia Palau, Rafael de la Espriella, Julia Seller, Enrique Santas, Eloy Domínguez, Vicent Bodí, Juan Sanchis, Eduardo Núñez, Antoni Bayés-Genís, Vicente Bertomeu-González, Markus Meyer, Julio Núñez
ImportanceIncreasing the patient’s heart rate (HR) has emerged as a therapeutic option in patients with heart failure with preserved ejection fraction (HFpEF). However, the evidence is conflicting, and the profile of patients who benefit most from this strategy remains unclear.ObjectiveTo assess the association of β-blocker treatment withdrawal with changes in the percentage of predicted peak oxygen
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Transient Monocular Blindness in a Man in His 30s JAMA Cardiol. (IF 24.0) Pub Date : 2024-02-07 Jérôme Antonelli, Jean-Philippe Verhoye, Raphaël P. Martins
This case report discusses a diagnosis of giant ascending aortic aneurysm in a patient who presented with transient monocular blindness and no cardiovascular symptoms.
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Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-31 Yiyi Zhang, Jacqueline S. Dron, Brandon K. Bellows, Amit V. Khera, Junxiu Liu, Pallavi P. Balte, Elizabeth C. Oelsner, Sami Samir Amr, Matthew S. Lebo, Anna Nagy, Gina M. Peloso, Pradeep Natarajan, Jerome I. Rotter, Cristen Willer, Eric Boerwinkle, Christie M. Ballantyne, Pamela L. Lutsey, Myriam Fornage, Donald M. Lloyd-Jones, Lifang Hou, Bruce M. Psaty, Joshua C. Bis, James S. Floyd, Ramachandran
ImportanceFamilial hypercholesterolemia (FH) is a genetic disorder that often results in severely high low-density lipoprotein cholesterol (LDL-C) and high risk of premature coronary heart disease (CHD). However, the impact of FH variants on CHD risk among individuals with moderately elevated LDL-C is not well quantified.ObjectiveTo assess CHD risk associated with FH variants among individuals with
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Machine Learning Multicenter Risk Model to Predict Right Ventricular Failure After Mechanical Circulatory Support JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-31 Iosif Taleb, Christos P. Kyriakopoulos, Robyn Fong, Naila Ijaz, Zachary Demertzis, Konstantinos Sideris, Omar Wever-Pinzon, Antigone G. Koliopoulou, Michael J. Bonios, Rohan Shad, Adithya Peruri, Thomas C. Hanff, Elizabeth Dranow, Theodoros V. Giannouchos, Ethan Krauspe, Cyril Zakka, Daniel G. Tang, Hassan W. Nemeh, Josef Stehlik, James C. Fang, Craig H. Selzman, Rami Alharethi, William T. Caine, Jennifer
ImportanceThe existing models predicting right ventricular failure (RVF) after durable left ventricular assist device (LVAD) support might be limited, partly due to lack of external validation, marginal predictive power, and absence of intraoperative characteristics.ObjectiveTo derive and validate a risk model to predict RVF after LVAD implantation.Design, Setting, and ParticipantsThis was a hybrid
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What Is Your Secret to Health? JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-31 Rebecca Ann Levine
This essay describes how asking a single simple question helps the author understand the factors most important to patients and that could be indirectly considered the secret to their lives’ health, happiness, and longevity.
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Emphasizing Sexual Orientation and Gender Identity Data Capture for Improved Cardiovascular Care of the LGBTQ+ Population JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-24 Brototo Deb, Kadijah Porter, Ashlan van Cleeff, Leigh C. Reardon, Stephen Cook
ImportanceThe rising self-identifying lesbian, gay, bisexual, transgender, and queer (LGBTQ+) population makes understanding the unique health care needs of sexual and gender minoritized patients an urgent one. The interaction between minority stress and cardiovascular disease has been well described among underrepresented minoritized populations. The underrepresentation of minoritized populations
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Recruiting a Diverse Cardiology Physician Workforce JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-24 Sarah C. Snow, Brooke Alhanti, Pamela S. Douglas
ImportanceUnderstanding trends in the representation of women and individuals from underrepresented racial and ethnic populations in cardiovascular disease and cardiovascular subspecialty fellowships is essential to improving the diversity of the cardiology workforce.ObjectiveTo examine changes in the representation of women and underrepresented individuals in cardiovascular disease and cardiovascular
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Dapagliflozin and Mode of Death in Heart Failure With Improved Ejection Fraction JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-24 Orly Vardeny, Akshay S. Desai, Pardeep S. Jhund, James C. Fang, Brian Claggett, Rudolf A. de Boer, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe A. Martinez, Sanjiv J. Shah, Finnian R. Mc Causland, Mark C. Petrie, Muthiah Vaduganathan, John J. V. McMurray, Scott D. Solomon
ImportanceHeart failure with improved ejection fraction (HFimpEF), defined as prior left ventricular ejection fraction (LVEF) 40% or lower that has increased to greater than 40%, is understudied.ObjectiveTo examine mode of death and the association of dapagliflozin with reductions in cause-specific death in patients with HFimpEF.Design, Setting, and ParticipantsThis was a post hoc analysis from the
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Polygenic Risk in Families With Spontaneous Coronary Artery Dissection JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-24 Ingrid Tarr, Stephanie Hesselson, Michael Troup, Paul Young, Jamie-Lee Thompson, Lucy McGrath-Cadell, Diane Fatkin, Sally L. Dunwoodie, David W. M. Muller, Siiri E. Iismaa, Jason C. Kovacic, Robert M. Graham, Eleni Giannoulatou
ImportanceSpontaneous coronary artery dissection (SCAD) is a poorly understood cause of acute coronary syndrome that predominantly affects women. Evidence to date suggests a complex genetic architecture, while a family history is reported for a minority of cases.ObjectiveTo determine the contribution of rare and common genetic variants to SCAD risk in familial cases, the latter via the comparison of
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A Female Patient With Recurrent Headache and Syncope JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-17 Huai-Xue Mi, Xiao-Zhou Zheng, Li Hongxin
This case report discusses a diagnosis of pulmonary arteriovenous fistulas in a female patient in her 30s who presented with a 5-year history of hypoxia, syncope, and headaches.
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Impact of Bempedoic Acid on Total Cardiovascular Events JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-17 Stephen J. Nicholls, Adam J. Nelson, A. Michael Lincoff, Danielle Brennan, Kausik K. Ray, Leslie Cho, Venu Menon, Na Li, LeAnne Bloedon, Steven E. Nissen
ImportanceThe ATP citrate lyase (ACL) inhibitor, bempedoic acid, reduces low-density lipoprotein cholesterol (LDL-C) level and major adverse cardiovascular events (MACE) by 13% in patients at high cardiovascular risk with intolerance of statin and high-intensity statin medications. The effects of bempedoic acid on total cardiovascular events remain unknown.ObjectiveTo determine the impact of bempedoic
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Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-10 Kun Zhao, Xuxiang Shen, Hongwei Liu, Zhennan Lin, Jianxin Li, Shufeng Chen, Fangchao Liu, Keyong Huang, Jie Cao, Xiaoqing Liu, Chong Shen, Ling Yu, Yingxin Zhao, Liancheng Zhao, Ying Li, Dongsheng Hu, Jiangfeng Huang, Xiangfeng Lu, Dongfeng Gu
ImportanceThe genetic basis of coronary heart disease (CHD) has expanded from a germline to somatic genome, including clonal hematopoiesis of indeterminate potential (CHIP). How CHIP confers CHD risk in East Asian individuals, especially those with small clones (variant allele fraction [VAF] 0.5%-2%) and different genetic backgrounds, was completely unknown.ObjectiveTo investigate the CHIP profile
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Bundled Payments for Care Improvement and Quality of Care and Outcomes in Heart Failure JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-03 D. August Oddleifson, DaJuanicia N. Holmes, Brooke Alhanti, Xiao Xu, Paul A. Heidenreich, Rishi K. Wadhera, Larry A. Allen, Stephen J. Greene, Gregg C. Fonarow, Erica S. Spatz, Nihar R. Desai
ImportanceThe Centers for Medicare & Medicaid Services (CMS) Bundled Payments for Care Improvement (BPCI) program was launched in 2013 with a goal to improve care quality while lowering costs to Medicare.ObjectiveTo compare changes in the quality and outcomes of care for patients hospitalized with heart failure according to hospital participation in the BPCI program.Design, Setting, and ParticipantsThis
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Genetic Associations of Circulating Cardiovascular Proteins With Gestational Hypertension and Preeclampsia JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-03 Art Schuermans, Buu Truong, Maddalena Ardissino, Rohan Bhukar, Eric A. W. Slob, Tetsushi Nakao, Jacqueline S. Dron, Aeron M. Small, So Mi Jemma Cho, Zhi Yu, Whitney Hornsby, Tajmara Antoine, Kim Lannery, Darina Postupaka, Kathryn J. Gray, Qi Yan, Adam S. Butterworth, Stephen Burgess, Malissa J. Wood, Nandita S. Scott, Colleen M. Harrington, Amy A. Sarma, Emily S. Lau, Jason D. Roh, James L. Januzzi
ImportanceHypertensive disorders of pregnancy (HDPs), including gestational hypertension and preeclampsia, are important contributors to maternal morbidity and mortality worldwide. In addition, women with HDPs face an elevated long-term risk of cardiovascular disease.ObjectiveTo identify proteins in the circulation associated with HDPs.Design, Setting, and ParticipantsTwo-sample mendelian randomization
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Cardiac Perforation After Pacemaker Placement in a Male Patient in His 80s JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-03 Nicola Guglielmo, Daniele Orso
This case report describes a diagnosis of cardiac perforation secondary to pacemaker placement in a male patient in his 80s who presented with pulsing chest pain.
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Hypoglycemia and Cardiovascular Outcomes in the CARMELINA and CAROLINA Trials of Linagliptin JAMA Cardiol. (IF 24.0) Pub Date : 2024-01-03 Nikolaus Marx, Ahmed A. Kolkailah, Julio Rosenstock, Odd Erik Johansen, Mark E. Cooper, John H. Alexander, Robert D. Toto, Christoph Wanner, Mark A. Espeland, Michaela Mattheus, Sven Schnaidt, Vlado Perkovic, Nicholas D. Gollop, Darren K. McGuire
ImportancePrevious studies have reported an association between hypoglycemia and cardiovascular (CV) events in people with type 2 diabetes (T2D), but it is unclear if this association is causal or identifies a high-risk patient phenotype.ObjectiveTo evaluate the associations between hypoglycemia and CV outcomes.Design, Setting, and ParticipantsThis secondary analysis was a post hoc assessment of the
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Can Noncalcified Plaques Contribute to Future Coronary Events?-Reply. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-29 Alastair J Moss,Michelle C Williams,David E Newby
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Pulsed Field Ablation-Will Coronary Spasm Lead to Iconoclasm? JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-29 Bradley P Knight,Anna Pfenniger
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Coronary Artery Spasm During Pulsed Field vs Radiofrequency Catheter Ablation of the Mitral Isthmus. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-29 Chi Zhang,Petr Neuzil,Jan Petru,Moritoshi Funasako,Pavel Hala,Karel Kopriva,Jacob S Koruth,Srinivas R Dukkipati,Vivek Y Reddy
Importance In treating atrial fibrillation, pulsed field ablation (PFA) is a novel energy modality with comparable efficacy to conventional thermal ablation, such as radiofrequency ablation (RFA), but with the benefit of some preferentiality to myocardial tissue ablation. Studies have demonstrated important safety advantages, including the absence of esophageal injury or pulmonary vein stenosis and
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Can Noncalcified Plaques Contribute to Future Coronary Events? JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-29 Muhammed I Erbay,Shriraj Susarla,Matthew J Budoff
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High-Sensitivity Troponin in Pulmonary Embolism Risk Stratification-Proceed With Caution. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-22 Vinay Guduguntla,Robert O Bonow
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High-Sensitivity vs Conventional Troponin Cutoffs for Risk Stratification in Patients With Acute Pulmonary Embolism. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-22 Behnood Bikdeli,Alfonso Muriel,Carmen Rodríguez,Sara González,Winnifer Briceño,Ghazaleh Mehdipoor,Gregory Piazza,Aitor Ballaz,Giuseppe Lippi,Roger D Yusen,Remedios Otero,David Jiménez
Importance High-sensitivity troponin tests can detect even milder cardiac troponin elevations in plasma, beyond the threshold of conventional troponin tests. Whether detection of low-grade cardiac troponin elevation is associated with outcomes of patients with hemodynamically stable pulmonary embolism (PE) and helps with risk stratification is unknown. Objective To determine the association between
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Abbreviated or Standard Dual Antiplatelet Therapy by Sex in Patients at High Bleeding Risk: A Prespecified Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-22 Antonio Landi,Mirvat Alasnag,Dik Heg,Enrico Frigoli,Fazila Tun Nesa Malik,Ivan Gomez-Blazquez,Suzanne Pourbaix,Alaide Chieffo,Christian Spaulding,Fermin Sainz,Helen Routledge,Giuseppe Andò,Luca Testa,Alessandro Sciahbasi,Hussain Contractor,Nigel Jepson,Juan Mieres,Syed Saqib Imran,Husam Noor,Pieter C Smits,Marco Valgimigli,
Importance Abbreviated dual antiplatelet therapy (DAPT) reduces bleeding with no increase in ischemic events in patients at high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI). Objectives To evaluate the association of sex with the comparative effectiveness of abbreviated vs standard DAPT in patients with HBR. Design, Setting, and Patients This prespecified subgroup comparative
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Effect of Tafamidis on Cardiac Function in Patients With Transthyretin Amyloid Cardiomyopathy: A Post Hoc Analysis of the ATTR-ACT Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-15 Sanjiv J Shah,Nowell Fine,Pablo Garcia-Pavia,Allan L Klein,Fabio Fernandes,Neil J Weissman,Mathew S Maurer,Kurt Boman,Balarama Gundapaneni,Marla B Sultan,Perry Elliott
Importance Tafamidis has been shown to improve survival in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) compared with placebo. However, its effect on cardiac function has not been fully characterized. Objective To examine the effect of tafamidis on cardiac function in patients with ATTR-CM. Design, Setting, and Participants This was an exploratory, post hoc analysis of the Tafamidis
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Swollen Right Upper Limb in a Man in His 60s Undergoing Hemodialysis. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-15 Shengmei Liu,Sixian Hu,Liqing Peng
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Irregular Rhythm in a Middle-Aged Man Presenting With New-Onset Heart Failure. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-15 Hussam Ali,Ilaria Passarelli,Riccardo Cappato
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Torsemide vs Furosemide Among Patients With New-Onset vs Worsening Chronic Heart Failure: A Substudy of the TRANSFORM-HF Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-13 Selim R Krim,Senthil Anand,Stephen J Greene,Anqi Chen,Daniel Wojdyla,Juan Vilaro,Herbert Haught,John M Herre,Eric L Eisenstein,Kevin J Anstrom,Bertram Pitt,Eric J Velazquez,Robert J Mentz
Importance Differences in clinical profiles, outcomes, and diuretic treatment effects may exist between patients with de novo heart failure (HF) and worsening chronic HF (WHF). Objectives To compare clinical characteristics and treatment outcomes of torsemide vs furosemide in patients hospitalized with de novo HF vs WHF. Design, Setting, and Participants All patients with a documented ejection fraction
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Neighborhood Environmental Burden and Cardiovascular Health in the US. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-13 Michael Liu,Vishal R Patel,Renee N Salas,Mary B Rice,Dhruv S Kazi,ZhaoNian Zheng,Rishi K Wadhera
Importance Cardiovascular disease is the leading cause of death in the US. However, little is known about the association between cumulative environmental burden and cardiovascular health across US neighborhoods. Objective To evaluate the association of neighborhood-level environmental burden with prevalence of cardiovascular risk factors and diseases, overall and by levels of social vulnerability
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Prioritizing the Exposome to Reduce Cardiovascular Disease Burden. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-13 Erica S Spatz,Kai Chen,Harlan M Krumholz
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Decline in Estimated Glomerular Filtration Rate After Dapagliflozin in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Secondary Analysis of the DELIVER Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-12 Finnian R Mc Causland,Brian L Claggett,Muthiah Vaduganathan,Akshay Desai,Pardeep Jhund,Orly Vardeny,James C Fang,Rudolf A de Boer,Kieran F Docherty,Adrian F Hernandez,Silvio E Inzucchi,Mikhail N Kosiborod,Carolyn S P Lam,Felipe Martinez,Jose F Kerr Saraiva,Martina M McGrath,Sanjiv J Shah,Subodh Verma,Anna Maria Langkilde,Magnus Petersson,John J V McMurray,Scott D Solomon
Importance An initial decline in estimated glomerular filtration rate (eGFR) is expected after initiating a sodium-glucose cotransporter-2 inhibitor (SGLT2i) and has been observed across patients with diabetes, chronic kidney disease, and heart failure. Objective To examine the implications of initial changes in eGFR among patients with heart failure with mildly reduced ejection fraction (HFmrEF) or
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Natural Language Processing for Adjudication of Heart Failure in a Multicenter Clinical Trial: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-11 Jonathan W Cunningham,Pulkit Singh,Christopher Reeder,Brian Claggett,Pablo M Marti-Castellote,Emily S Lau,Shaan Khurshid,Puneet Batra,Steven A Lubitz,Mahnaz Maddah,Anthony Philippakis,Akshay S Desai,Patrick T Ellinor,Orly Vardeny,Scott D Solomon,Jennifer E Ho
Importance The gold standard for outcome adjudication in clinical trials is medical record review by a physician clinical events committee (CEC), which requires substantial time and expertise. Automated adjudication of medical records by natural language processing (NLP) may offer a more resource-efficient alternative but this approach has not been validated in a multicenter setting. Objective To externally
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Innovation in Event Adjudication-Human vs Machine. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-11 Kenneth W Mahaffey,C Michael Gibson,Renato D Lopes
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Mendelian Randomization and Cardiovascular Disease-Enabling Expert Readership. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-08 Pradeep Natarajan,Clyde W Yancy
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Long-Term Clinical and Echocardiographic Outcomes Following the Ross Procedure: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-08 Maximiliaan L Notenboom,Giovanni Melina,Kevin M Veen,Fabio De Robertis,Giuditta Coppola,Paolo De Siena,Emiliano M Navarra,Jullien Gaer,Michael E K Ibrahim,Ismail El-Hamamsy,Johanna J M Takkenberg,Magdi H Yacoub
Importance The Ross procedure as treatment for adults with aortic valve disease (AVD) has been the subject of renewed interest. Objective To evaluate the long-term clinical and echocardiographic outcomes following the Ross procedure for the treatment of adults with AVD. Design, Setting, and Participants This post hoc analysis of a randomized clinical trial included adult patients (age <69 years) who
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Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-08 June-Wha Rhee,Raju Pillai,Tianhui He,Alysia Bosworth,Sitong Chen,Liezl Atencio,Artem Oganesyan,Kelly Peng,Tati Guzman,Kara Lukas,Brianna Sigala,Aleksi Iukuridze,Lanie Lindenfeld,Faizi Jamal,Pradeep Natarajan,Scott Goldsmith,Amrita Krishnan,Michael Rosenzweig,F Lennie Wong,Stephen J Forman,Saro Armenian
Importance There is a paucity of information on the association between clonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular disease (CVD) in patients with cancer, including those with multiple myeloma (MM) undergoing hematopoietic cell transplant (HCT), a population at high risk of developing CVD after HCT. Objective To examine the association between CHIP and CVD in patients
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The Longest Reported Outcomes of the Ross Procedure. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-08 Tsuyoshi Kaneko,Maral Ouzounian
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Mendelian Randomization as a Tool for Cardiovascular Research: A Review. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-08 Michael G Levin,Stephen Burgess
Importance Mendelian randomization (MR) is a statistical approach that has become increasingly popular in the field of cardiovascular disease research. It offers a way to infer potentially causal relationships between risk factors and outcomes using observational data, which is particularly important in cases where randomized clinical trials are not feasible or ethical. With the growing availability
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Mitochondrial Respiration and Exercise Performance in Patients With Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Johannes Burtscher,Martin Burtscher
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Mitochondrial Respiration and Exercise Performance in Patients With Heart Failure With Preserved Ejection Fraction-Reply. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Anthony J A Molina,Erich Gnaiger,Dalane W Kitzman
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Educational Attainment and Lifetime Risk of Cardiovascular Disease. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Jared W Magnani,Hongyan Ning,John T Wilkins,Donald M Lloyd-Jones,Norrina B Allen
Importance Education is a social determinant of health. Quantifying its association with lifetime cardiovascular disease (CVD) risk has public health importance. Objective To calculate lifetime risk estimates of incident CVD and CVD subtypes and estimate years lived with and without CVD by education. Design, Setting, and Participants Included community-based cohort studies with adjudicated cardiovascular
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Clinical Outcomes by Sex After Pulsed Field Ablation of Atrial Fibrillation. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Mohit K Turagam,Petr Neuzil,Boris Schmidt,Tobias Reichlin,Kars Neven,Andreas Metzner,Jim Hansen,Yuri Blaauw,Philippe Maury,Thomas Arentz,Philipp Sommer,Ante Anic,Frederic Anselme,Serge Boveda,Tom Deneke,Stephan Willems,Pepijn van der Voort,Roland Tilz,Moritoshi Funasako,Daniel Scherr,Reza Wakili,Daniel Steven,Josef Kautzner,Johan Vijgen,Pierre Jais,Jan Petru,Julian Chun,Laurent Roten,Anna Füting,Marc
Importance Previous studies evaluating the association of patient sex with clinical outcomes using conventional thermal ablative modalities for atrial fibrillation (AF) such as radiofrequency or cryoablation are controversial due to mixed results. Pulsed field ablation (PFA) is a novel AF ablation energy modality that has demonstrated preferential myocardial tissue ablation with a unique safety profile
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Pulsed Field Closes Gender Gap in Atrial Fibrillation Ablation-Electrifying Insights. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Peter M Kistler,Louise Segan
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Prevalence, Awareness, and Treatment of Elevated LDL Cholesterol in US Adults, 1999-2020. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Ahmed Sayed,Ann Marie Navar,Leandro Slipczuk,Christie M Ballantyne,Zainab Samad,Carl J Lavie,Salim S Virani
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Effectiveness and Safety of Enteric-Coated vs Uncoated Aspirin in Patients With Cardiovascular Disease: A Secondary Analysis of the ADAPTABLE Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Amber Sleem,Mark B Effron,Amanda Stebbins,Lisa M Wruck,Guillaume Marquis-Gravel,Daniel Muñoz,Richard N Re,Kamal Gupta,Carl J Pepine,Sandeep K Jain,Saket Girotra,Jeffrey Whittle,Catherine P Benziger,Peter M Farrehi,Kirk U Knowlton,Tamar S Polonsky,Matthew T Roe,Russell L Rothman,Robert A Harrington,W Schuyler Jones,Adrian F Hernandez
Importance Clinicians recommend enteric-coated aspirin to decrease gastrointestinal bleeding in secondary prevention of coronary artery disease even though studies suggest platelet inhibition is decreased with enteric-coated vs uncoated aspirin formulations. Objective To assess whether receipt of enteric-coated vs uncoated aspirin is associated with effectiveness or safety outcomes. Design, Setting
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Is There a Need for Palliative Care for Patients With Heart Failure With Preserved Ejection Fraction? JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Sarah Godfrey,Ambarish Pandey,Haider J Warraich
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Woman in Her 50s With an Intravenous Mass Extending to the Right Cardiac Chamber. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Jiehua Li,Quanming Li,Chang Shu
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The Role of Posterior Wall Isolation in Catheter Ablation for Persistent Atrial Fibrillation and Systolic Heart Failure: A Secondary Analysis of a Randomized Clinical Trial. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Jeremy William,David Chieng,Hariharan Sugumar,Liang-Han Ling,Louise Segan,Rose Crowley,Ahmed Al-Kaisey,Joshua Hawson,Sandeep Prabhu,Aleksandr Voskoboinik,Geoffrey Wong,Joseph B Morton,Geoffrey Lee,Alex J McLellan,Michael Wong,Rajeev K Pathak,Laurence Sterns,Matthew Ginks,Christopher M Reid,Prashanthan Sanders,Jonathan M Kalman,Peter M Kistler
Importance Catheter ablation for patients with atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) is associated with improved left ventricular ejection fraction (LVEF) and survival compared with medical therapy. Nonrandomized studies have reported improved success with posterior wall isolation (PWI). Objective To determine the impact of pulmonary vein isolation (PVI)
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Health and Economic Evaluation of Sacubitril-Valsartan for Heart Failure Management. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Ankeet S Bhatt,Muthiah Vaduganathan,Brian L Claggett,Gregg C Fonarow,Milton Packer,Marc A Pfeffer,Sanjiv J Shah,Xian Shen,Joaquim Cristino,John J V McMurray,Scott D Solomon,Thomas A Gaziano
Importance The US Food and Drug Administration expanded labeling of sacubitril-valsartan from the treatment of patients with chronic heart failure (HF) with reduced ejection fraction (EF) to all patients with HF, noting the greatest benefits in those with below-normal EF. However, the upper bound of below normal is not clearly defined, and value determinations across a broader EF range are unknown
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Economic Evaluation of Angiotensin-Neprilysin Inhibitors Across Ejection Fractions. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 Laura P Cohen,Brandon K Bellows
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Prevalence and Overlap of Cardiac, Renal, and Metabolic Conditions in US Adults, 1999-2020. JAMA Cardiol. (IF 24.0) Pub Date : 2023-11-01 John W Ostrominski,Suzanne V Arnold,Javed Butler,Gregg C Fonarow,Jamie S Hirsch,Swetha R Palli,Bonnie M K Donato,Christina M Parrinello,Thomas O'Connell,Eric B Collins,Jonathan J Woolley,Mikhail N Kosiborod,Muthiah Vaduganathan
Importance Individually, cardiac, renal, and metabolic (CRM) conditions are common and leading causes of death, disability, and health care-associated costs. However, the frequency with which CRM conditions coexist has not been comprehensively characterized to date. Objective To examine the prevalence and overlap of CRM conditions among US adults currently and over time. Design, Setting, and Participants