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Associations of nighttime sleep, midday napping, and physical activity with all-cause mortality in older adults: the Seniors-ENRICA cohorts. Geroscience (IF 5.3) Pub Date : 2024-09-20 Miguel Angelo Duarte Junior,David Martinez-Gomez,Salud Pintos-Carrillo,Esther Lopez-Garcia,Fernando Rodríguez-Artalejo,Verónica Cabanas-Sánchez
We examined associations between nighttime sleep and midday nap duration with all-cause mortality according to adherence to moderate-to-vigorous physical activity (MVPA) recommendations in older adults. We used data from 3518 and 3273 older adults recruited in the Seniors-ENRICA-1 and 2 cohorts, respectively. Nighttime sleep time was classified as short (< 7 h), middle (≥ 7 and < 8 h), and long (≥ 8
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An antireductant approach ameliorates misfolded proinsulin-induced hyperglycemia and glucose intolerance in male Akita mice Geroscience (IF 5.3) Pub Date : 2024-09-19 Dwight A. L. Mattocks, Naidu B. Ommi, Virginia L. Malloy, Sailendra N. Nichenametla
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Resistance training suppresses accumulation of senescent fibro-adipogenic progenitors and senescence-associated secretory phenotype in aging rat skeletal muscle Geroscience (IF 5.3) Pub Date : 2024-09-19 Yung-Li Hung, Ayami Sato, Yuka Takino, Akihito Ishigami, Shuichi Machida
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Dietary factors and DNA methylation-based markers of ageing in 5310 middle-aged and older Australian adults Geroscience (IF 5.3) Pub Date : 2024-09-19 Lachlan Cribb, Allison M. Hodge, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Pierre-Antoine Dugué
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Systemic low-dose anti-fibrotic treatment attenuates ovarian aging in the mouse Geroscience (IF 5.3) Pub Date : 2024-09-16 Farners Amargant, Carol Magalhaes, Michele T. Pritchard, Francesca E. Duncan
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Calorie restriction increases the sensitivity of progeroid Ercc1Δ/− mice to acute (neuro)inflammation Geroscience (IF 5.3) Pub Date : 2024-09-17 V. A. Reitsema, L. Schreuder, E. Gerrits, B. J. L. Eggen, M. Goris, J. D. Laman, S. E. de Rooij, E. M. Wesseling, H. R. Bouma, R. H. Henning
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Age-related breakdown in networks of inter-muscular coordination Geroscience (IF 5.3) Pub Date : 2024-09-17 Sergi Garcia-Retortillo, Óscar Abenza, Fidanka Vasileva, Natàlia Balagué, Robert Hristovski, Andrew Wells, Jason Fanning, Jeff Kattula, Plamen Ch. Ivanov
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Fixel-based and tensor-derived white matter abnormalities in relation to memory impairment and neurocognitive disorders Geroscience (IF 5.3) Pub Date : 2024-09-13 Charly Hugo Alexandre Billaud, Junhong Yu
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Multiscale neural dynamics in sleep transition volatility across age scales: a multimodal EEG-EMG-EOG analysis of temazepam effects Geroscience (IF 5.3) Pub Date : 2024-09-14 Parikshat Sirpal, William A. Sikora, Hazem H. Refai
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Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease Geroscience (IF 5.3) Pub Date : 2024-09-14 Michelle M. Sonsalla, Reji Babygirija, Madeline Johnson, Samuel Cai, Mari Cole, Chung-Yang Yeh, Isaac Grunow, Yang Liu, Diana Vertein, Mariah F. Calubag, Michaela E. Trautman, Cara L. Green, Michael J. Rigby, Luigi Puglielli, Dudley W. Lamming
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The vasoprotective role of IGF-1 signaling in the cerebral microcirculation: prevention of cerebral microhemorrhages in aging Geroscience (IF 5.3) Pub Date : 2024-09-14 Levente Stankovics, Anna Ungvari, Mónika Fekete, Adam Nyul-Toth, Peter Mukli, Roland Patai, Boglarka Csik, Rafal Gulej, Shannon Conley, Anna Csiszar, Peter Toth
Aging is closely associated with various cerebrovascular pathologies that significantly impact brain function, with cerebral small vessel disease (CSVD) being a major contributor to cognitive decline in the elderly. Consequences of CSVD include cerebral microhemorrhages (CMH), which are small intracerebral bleeds resulting from the rupture of microvessels. CMHs are prevalent in aging populations, affecting
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Activation of the muscle-to-brain axis ameliorates neurocognitive deficits in an Alzheimer’s disease mouse model via enhancing neurotrophic and synaptic signaling Geroscience (IF 5.3) Pub Date : 2024-09-13 Hash Brown Taha, Allison Birnbaum, Ian Matthews, Karel Aceituno, Jocelyne Leon, Max Thorwald, Jose Godoy-Lugo, Constanza J. Cortes
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Coffee consumption, cancer, and healthy aging: epidemiological evidence and underlying mechanisms Geroscience (IF 5.3) Pub Date : 2024-09-13 Setor K. Kunutsor, Andrea Lehoczki, Jari A. Laukkanen
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Comprehensive analysis of molecular, physiological, and functional biomarkers of aging with neurological diseases using Mendelian randomization Geroscience (IF 5.3) Pub Date : 2024-09-13 Yume Imahori, Chenxi Qin, Bowen Tang, Sara Hägg
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Association of adherence to the EAT-Lancet diet with risk of dementia according to social economic status: a prospective cohort in UK Biobank Geroscience (IF 5.3) Pub Date : 2024-09-12 Wanying Zhao, Qian Chen, Qi Zhang, Siqi Li, Jiaqi Zhao, Wanlan Chen, Jialu Yang, Min Xia, Yan Liu
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Impact of healthcare system strain on the implementation of ICU sedation practices and encephalopathy burden during the early COVID-19 pandemic Geroscience (IF 5.3) Pub Date : 2024-09-07 Jeffrey R. Clark, Ayush Batra, Robert A. Tessier, Kasey Greathouse, Dan Dickson, Abeer Ammar, Brandon Hamm, Lisa J. Rosenthal, Theresa Lombardo, Igor J. Koralnik, Lesli E. Skolarus, Clara J. Schroedl, G. R. Scott Budinger, Richard G. Wunderink, Jane E. Dematte, Zoltan Ungvari, Eric M. Liotta
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Active longevity and aging: dissecting the impacts of physical and sedentary behaviors on longevity and age acceleration Geroscience (IF 5.3) Pub Date : 2024-09-04 Ting Yu Lu, Jiao Wang, Chao Qiang Jiang, Ya Li Jin, Kar Keung Cheng, Tai Hing Lam, Wei Sen Zhang, Lin Xu
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Effect of aging and exercise on hTERT expression in thymus tissue of hTERT transgenic bacterial artificial chromosome mice Geroscience (IF 5.3) Pub Date : 2024-09-02 Jeongjin J. Kim, Alexander Ahn, Jeffrey Y. Ying, Jesse Pollens-Voigt, Andrew T. Ludlow
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Do people reach 100 by surviving, delaying, or avoiding diseases? A life course comparison of centenarians and non-centenarians from the same birth cohorts Geroscience (IF 5.3) Pub Date : 2024-08-30 Yuge Zhang, Shunsuke Murata, Katharina Schmidt-Mende, Marcus Ebeling, Karin Modig
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Resistance training improves cardiac function in older women: a randomized controlled trial Geroscience (IF 5.3) Pub Date : 2024-08-31 Ricardo J. Rodrigues, Paolo M. Cunha, João P. Nunes, Lauro C. Vianna, Patrícia C. Brum, Danilo S. Bocalini, Andrei C. Sposito, Luis C. Miguita Junior, Max D. Oliveira, Elaine Batistella, Rodrigo R. Fernandes, Paulo S. Junior, Luís B. Sardinha, Edilson S. Cyrino
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The effect of cognitive reserve on the cognitive connectome in healthy ageing Geroscience (IF 5.3) Pub Date : 2024-08-29 Annegret Habich, Eloy Garcia-Cabello, Chiara Abbatantuono, Lissett Gonzalez-Burgos, Paolo Taurisano, Thomas Dierks, José Barroso, Daniel Ferreira
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Resting-state neural dynamics changes in older adults with post-COVID syndrome and the modulatory effect of cognitive training and sex Geroscience (IF 5.3) Pub Date : 2024-08-29 Boglárka Nagy, Andrea B. Protzner, Balázs Czigler, Zsófia Anna Gaál
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Association between self-reported difficulty in chewing or swallowing and frailty in older adults: A retrospective cohort study Geroscience (IF 5.3) Pub Date : 2024-08-30 So Sato, Yusuke Sasabuchi, Akira Okada, Hideo Yasunaga
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Effects of a 6-month dual-task, power-based exercise program on cognitive function, neurological and inflammatory markers in older adults: secondary analysis of a cluster randomised controlled trial Geroscience (IF 5.3) Pub Date : 2024-08-28 Jamie L. Tait, Rachel L. Duckham, Timo Rantalainen, Catherine M. Milte, Luana C. Main, Caryl A. Nowson, Kerrie M. Sanders, Dennis R. Taaffe, Keith D. Hill, Gavin Abbott, Robin M. Daly
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Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection Geroscience (IF 5.3) Pub Date : 2024-08-29 Zsófia Gáspár, Bálint Gergely Szabó, Andrea Ceglédi, Botond Lakatos
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Critical gap in practice—lack of attention to falls and possible fall-related post-concussion symptoms in older adults and individuals with neurodegenerative disease Geroscience (IF 5.3) Pub Date : 2024-08-29 Goldin Joghataie, Sabrina Hundal, Asma Mushtaque, Charles H. Tator, M. Carmela Tartaglia
Falls in older adults and those with neurodegenerative disease (ND) are a current public health hazard and the primary cause of sustaining a mild traumatic brain injury (mTBI)/concussion. Little is known regarding how post-concussion symptoms present in older adults and patients with ND, even though they are the demographic at highest risk. A combination of under-reporting of falls and a lack of awareness
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Gait Speed Reserve in the general population-based ‘Good Aging in Skåne’ cohort study—distribution and associated factors Geroscience (IF 5.3) Pub Date : 2024-08-27 Beata Lindholm, Rani Basna, Henrik Ekström, Sölve Elmståhl, Arkadiusz Siennicki-Lantz
Gait Speed Reserve (GSR) expresses a difference between fast and comfortable gait speed and may have an impact on everyday functioning. It was also hypothesized as a useful proxy measure of physiological reserve. However, height-normalizing values of GSR and its associated factors have not been evaluated in a general population of older adults. Therefore, we aimed to investigate the distribution of
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Electrical brain networks before and after transcranial pulsed shockwave stimulation in Alzheimer’s patients Geroscience (IF 5.3) Pub Date : 2024-08-27 Lars Wojtecki, Celine Cont, Natalie Stute, Anastasia Galli, Christina Schulte, Carlos Trenado
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Sleep onset time as a mediator in the association between screen exposure and aging: a cross-sectional study Geroscience (IF 5.3) Pub Date : 2024-08-27 Senlin Lin, Meng Gao, Juzhao Zhang, Yuting Wu, Tao Yu, Yajun Peng, Yingnan Jia, Haidong Zou, Lina Lu, Deshang Li, Yingyan Ma
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Two-month ketogenic diet alters systemic and brain metabolism in middle-aged female mice Geroscience (IF 5.3) Pub Date : 2024-08-24 Kirsten J. Roslund, Jon J. Ramsey, Jennifer M. Rutkowsky, Zeyu Zhou, Carolyn M. Slupsky
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Correction to: Molecular cross‑talk between long COVID‑19 and Alzheimer's disease. Geroscience (IF 5.3) Pub Date : 2024-10-01 Magdalena Pszczołowska,Kamil Walczak,Weronika Miśków,Katarzyna Antosz,Joanna Batko,Julia Karska,Jerzy Leszek
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Neuroanatomical and clinical factors predicting future cognitive impairment Geroscience (IF 5.3) Pub Date : 2024-08-17 Phoebe Imms, Nikhil N. Chaudhari, Nahian F. Chowdhury, Haoqing Wang, Xiaokun Yu, Anar Amgalan, Andrei Irimia
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Age-related alterations in vortex veins on indocyanine green angiography Geroscience (IF 5.3) Pub Date : 2024-08-15 Chen-Xi Cai, Shan-Shan Yu, Xiao-Mei Xiong, Bing-Qian Liu, Zhen-Qiang Lin, Qiang Wang, Jin-Li Cui, Ze-Hao Liu, Tao Li, Lin Lu, Ying Lin
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The role of atrial fibrillation in vascular cognitive impairment and dementia: epidemiology, pathophysiology, and preventive strategies Geroscience (IF 5.3) Pub Date : 2024-08-13 Mónika Fekete, Eric M. Liotta, Tihamer Molnar, Gábor A. Fülöp, Andrea Lehoczki
The aging population in Europe faces a substantial burden from dementia, with vascular cognitive impairment and dementia (VCID) being a preventable cause. Atrial fibrillation (AF), a common cardiac arrhythmia, increases the risk of VCID through mechanisms such as thromboembolism, cerebral hypoperfusion, and inflammation. This review explores the epidemiology, pathophysiology, and preventive strategies
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Sarcopenia and the management of spinal disease in the elderly Geroscience (IF 5.3) Pub Date : 2024-08-14 Alexander R. Evans, Lonnie Smith, Joshua Bakhsheshian, David B. Anderson, James M. Elliott, Hakeem J. Shakir, Zachary A. Smith
Sarcopenia, generally defined by the loss of skeletal mass and function, may disproportionately affect elderly individuals and heavily influence spinal disease. Muscle atrophy is associated with myriad clinical problems, including thoracic kyphosis, increased sagittal vertical axis (SVA), spinal implant failures, and postoperative complications. As such, the aim of this narrative review is to synthesize
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The RESIST Senior Individuals Cohort: Design, participant characteristics and aims Geroscience (IF 5.3) Pub Date : 2024-08-14 Lennart Matthias Roesner, Manoj Kumar Gupta, Verena Kopfnagel, Nienke van Unen, Yvonne Kemmling, Jana-Kristin Heise, Stephanie Castell, Xun Jiang, Lennart Riemann, Stephan Traidl, Berit Lange, Kurt-Wolfram Sühs, Thomas Illig, Till Strowig, Yang Li, Reinhold Förster, Jochen Huehn, Thomas Friedrich Schulz, Thomas Werfel
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Sport and longevity: an observational study of international athletes Geroscience (IF 5.3) Pub Date : 2024-08-12 Abdullah Altulea, Martijn G. S. Rutten, Lex B. Verdijk, Marco Demaria
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What is normal age-related thigh muscle composition among 45- to 84-year-old adults from the UK Biobank study Geroscience (IF 5.3) Pub Date : 2024-08-12 David B. Anderson, Aaron J. Beach, Lingxiao Chen, Henry J. Feng, Marnee J. McKay, Zachary A. Smith, Kenneth A. Weber, Evert Onno Wesselink, James M. Elliott
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Sex-specific clinical and neurobiological correlates of fatigue in older adults Geroscience (IF 5.3) Pub Date : 2024-08-12 Marco Toccaceli Blasi, Alba Rosa Alfano, Martina Salzillo, Simona Buscarnera, Valeria Raparelli, Matteo Cesari, Giuseppe Bruno, Marco Canevelli
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Impact of Helicobacter pylori eradication on age-specific risk of incident dementia in patients with peptic ulcer disease: a nationwide population-based cohort study Geroscience (IF 5.3) Pub Date : 2024-08-12 Dong Woo Kang, Jung-Won Lee, Man Young Park, Sung-Hwan Kim, Yoo Hyun Um, Sheng-Min Wang, Chang Uk Lee, Hyun Kook Lim
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Discriminative ability of instrumented cognitive-motor assessments to distinguish fallers from non-fallers Geroscience (IF 5.3) Pub Date : 2024-08-09 Julia Seinsche, Elena Kyprianou, Eling D. de Bruin, Enrico Saibene, Francesco Rizzo, Ilaria Carpinella, Lisa Lutz, Maurizio Ferrarin, Riccardo Villa, Savvina Chrysostomou, Sotiria Moza, Eleftheria Giannouli
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Senolytic intervention improves cognition, metabolism, and adiposity in female APPNL−F/NL−F mice Geroscience (IF 5.3) Pub Date : 2024-08-09 Yimin Fang, Mackenzie R. Peck, Kathleen Quinn, Jenelle E. Chapman, David Medina, Samuel A. McFadden, Andrzej Bartke, Erin R. Hascup, Kevin N. Hascup
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Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement Geroscience (IF 5.3) Pub Date : 2024-08-08 Zsuzsanna Ladányi, Tímea Bálint, Alexandra Fábián, Adrienn Ujvári, Tímea Katalin Turschl, Dávid Nagy, Éva Straub, Csaba Fejér, Endre Zima, Astrid Apor, Anikó Ilona Nagy, Tímea Szigethi, Roland Papp, Levente Molnár, Attila Kovács, Mihály Ruppert, Bálint Károly Lakatos, Béla Merkely
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Identifying sources of bias when testing three available algorithms for quantifying white matter lesions: BIANCA, LPA and LGA Geroscience (IF 5.3) Pub Date : 2024-08-08 Tatiana Miller, Nora Bittner, Susanne Moebus, Svenja Caspers
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Anti-aging interventions in geriatric mice: insights into the timing of treatment, benefits, and limitations Geroscience (IF 5.3) Pub Date : 2024-08-08 Marco Malavolta
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A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus) Geroscience (IF 5.3) Pub Date : 2024-08-06 Roshini Sathiaseelan, Jose V. V. Isola, Roberto Santín-Márquez, Daniel Adekunbi, Michal Fornalik, Adam B. Salmon, Michael B. Stout
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Gonadal status modulates large elastic artery stiffness in healthy middle-aged and older men Geroscience (IF 5.3) Pub Date : 2024-08-07 Lyndsey E. DuBose, Matthew C. Babcock, Wendy M. Kohrt, Brian L. Stauffer, Kerry L. Hildreth, Jacob Walker, Matthew K. Armstrong, Kerrie L. Moreau
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Right anterior insula ASL hypoperfusion as a diagnostic biomarker of prodromal and mild dementia with Lewy bodies: preliminary evidence using a Bayesian approach Geroscience (IF 5.3) Pub Date : 2024-08-07 Golda Gommel, Ludovic Jeanjean-Dormegny, Clément de Crespin de Billy, Olivier Mainberger, Augustin Moreau, Alexandre Obrecht, Rémi Vernet, Ilia Humbert, Benoit Schorr, Candice Muller, Catherine Demuynck, Paulo Loureiro de Sousa, Frédéric Blanc, Jack Foucher
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Characterizing dog cognitive aging using spontaneous problem-solving measures: development of a battery of tests from the Dog Aging Project Geroscience (IF 5.3) Pub Date : 2024-08-06 Stephanie H. Hargrave, Emily E. Bray, Stephanie McGrath, Gene E. Alexander, Theadora A. Block, Naomi Chao, Martin Darvas, Laura E. L. C. Douglas, Janet Galante, Brenda S. Kennedy, Breonna Kusick, Julie A. Moreno, Daniel E. L. Promislow, David A. Raichlen, Lorelei R. Switzer, Lily Tees, Mikayla Underwood Aguilar, Silvan R. Urfer, Evan L. MacLean
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Beat-to-beat blood pressure variability, hippocampal atrophy, and memory impairment in older adults Geroscience (IF 5.3) Pub Date : 2024-08-05 Trevor Lohman, Isabel Sible, Allison C. Engstrom, Arunima Kapoor, Fatemah Shenasa, Elizabeth Head, Lorena Sordo, John Paul M. Alitin, Aimee Gaubert, Amy Nguyen, Kathleen E. Rodgers, David Bradford, Daniel A. Nation
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From data to decisions: AI and functional connectivity for diagnosis, prognosis, and recovery prediction in stroke Geroscience (IF 5.3) Pub Date : 2024-08-01 Alessia Cacciotti, Chiara Pappalettera, Francesca Miraglia, Claudia Carrarini, Cristiano Pecchioli, Paolo Maria Rossini, Fabrizio Vecchio
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Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants Geroscience (IF 5.3) Pub Date : 2024-08-01 Zoltan Ungvari, Mónika Fekete, János Tibor Fekete, Giuseppe Grosso, Anna Ungvari, Balázs Győrffy
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Judith Campisi (1948–2024): tribute and personal memory Geroscience (IF 5.3) Pub Date : 2024-08-02 Steven N. Austad
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No association between markers of systemic inflammation and endothelial dysfunction with Alzheimer’s disease progression: a longitudinal study Geroscience (IF 5.3) Pub Date : 2024-07-31 Arne van Setten, Jeroen F. Uleman, René J. F. Melis, Brian Lawlor, Niels P. Riksen, Jurgen A. H. R. Claassen, Rianne A. A. de Heus
Introduction Systemic inflammation and endothelial dysfunction are potentially modifiable factors implicated in Alzheimer’s disease (AD), which offer potential therapeutic targets to slow disease progression. Methods We investigated the relationship between baseline circulating levels of inflammatory (TNF-α, IL-1ß) and endothelial cell markers (VCAM-1, ICAM-1, E-selectin) and 18-month cognitive decline
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Age-associated proteins explain the role of medial temporal lobe networks in Alzheimer’s disease Geroscience (IF 5.3) Pub Date : 2024-07-31 Adam Turnbull, Yejin Kim, Kai Zhang, Xiaoqian Jiang, Zihuai He, Victor W. Henderson, F. Vankee Lin
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The untapped potential of cold water therapy as part of a lifestyle intervention for promoting healthy aging Geroscience (IF 5.3) Pub Date : 2024-07-30 Setor K. Kunutsor, Andrea Lehoczki, Jari A. Laukkanen
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Biological aging of different blood cell types Geroscience (IF 5.3) Pub Date : 2024-07-26 Saara Marttila, Sonja Rajić, Joanna Ciantar, Jonathan K. L. Mak, Ilkka S. Junttila, Laura Kummola, Sara Hägg, Emma Raitoharju, Laura Kananen
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Cross-platform proteomics signatures of extreme old age Geroscience (IF 5.3) Pub Date : 2024-07-25 Eric R. Reed, Kevin B. Chandler, Prisma Lopez, Catherine E. Costello, Stacy L. Andersen, Thomas T. Perls, Mengze Li, Harold Bae, Mette Soerensen, Stefano Monti, Paola Sebastiani
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Association of sarcopenia with regional brain atrophy and white matter lesions in a general older population: the Hisayama Study Geroscience (IF 5.3) Pub Date : 2024-07-23 Takahiro Tajimi, Naoki Hirabayashi, Yoshihiko Furuta, Taro Nakazawa, Takanori Honda, Jun Hata, Tomoyuki Ohara, Mao Shibata, Takanari Kitazono, Yasuharu Nakashima, Toshiharu Ninomiya
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Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy Geroscience (IF 5.3) Pub Date : 2024-07-22 Steve Horvath, Ezequiel Lacunza, Martina Canatelli Mallat, Enrique L. Portiansky, Maria D. Gallardo, Robert T. Brooke, Priscila Chiavellini, Diana C. Pasquini, Mauricio Girard, Marianne Lehmann, Qi Yan, Ake T. Lu, Amin Haghani, Juozas Gordevicius, Martin Abba, Rodolfo G. Goya