-
Brain Network Localization of Gray Matter Atrophy and Neurocognitive and Social Cognitive Dysfunction in Schizophrenia Biol. Psychiatry (IF 9.6) Pub Date : 2024-08-03 Yan Cheng, Huanhuan Cai, Siyu Liu, Yang Yang, Shan Pan, Yongqi Zhang, Fan Mo, Yongqiang Yu, Jiajia Zhu
Numerous studies have established the presence of gray matter atrophy and brain activation abnormalities during neurocognitive and social cognitive tasks in schizophrenia. Despite a growing consensus that diseases localize better to distributed brain networks than individual anatomical regions, relatively few studies have examined brain network localization of gray matter atrophy and neurocognitive
-
An Astroglial Basis of Major Depressive Disorder: Molecular, Cellular, and Circuit Features Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-29 Cheng-Lin Lu, Jing Ren, Xiong Cao
Major depressive disorder is a common psychiatric disorder and a leading cause of disability worldwide. Astrocytes play a role in the maintenance of the function of the central nervous system, both physiologically and pathologically. Accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of major depressive disorder including blood-brain barrier integrity
-
Cardiovascular Consequences of Posttraumatic Stress Disorder: Exaggerated Vasoconstrictor Responsiveness to Personalized Trauma Recall Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-22 Nathaniel D.M. Jenkins
-
Treatment Approaches for Posttraumatic Stress Disorder Derived From Basic Research on Fear Extinction Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-18 Jessica L. Maples-Keller, Laura Watkins, Natalie Hellman, Nathaniel L. Phillips, Barbara O. Rothbaum
This brief review article will describe treatment approaches for posttraumatic stress disorder (PTSD) based on findings from basic research. The focus of this review will be fear conditioning and extinction models, which provide a translational model of PTSD that can help translate basic research in nonhuman animals through well-controlled trials confirming the efficacy of treatment approaches in humans
-
Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-18 Heather Burrell Ward, Adam Beermann, Jing Xie, Gulcan Yildiz, Karlos Manzanarez Felix, Jean Addington, Carrie E. Bearden, Kristin Cadenhead, Tyrone D. Cannon, Barbara Cornblatt, Matcheri Keshavan, Daniel Mathalon, Diana O. Perkins, Larry Seidman, William S. Stone, Ming T. Tsuang, Elaine F. Walker, Scott Woods, Michael J. Coleman, Sylvain Bouix, Daphne J. Holt, Dost Öngür, Alan Breier, Martha E. Shenton
Neurocognitive impairment is a well-known phenomenon in schizophrenia that begins prior to psychosis onset. Connectome-wide association studies have inconsistently linked cognitive performance to resting-state functional magnetic resonance imaging. We hypothesized that a carefully selected cognitive instrument and refined population would allow identification of reliable brain-behavior associations
-
Transthyretin Orchestrates Vitamin B12–Induced Stress Resilience Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-17 Gregor Stein, Janine S. Aly, Annamaria Manzolillo, Lisa Lange, Konstantin Riege, Iqra Hussain, Elisabeth A. Heller, Susana Cubillos, Thomas Ernst, Christian A. Hübner, Gustavo Turecki, Steve Hoffmann, Olivia Engmann
Chronic stress significantly contributes to mood and anxiety disorders. Previous data suggest a correlative connection between vitamin B12 supplementation, depression, and stress resilience. However, the underlying mechanisms are still poorly understood. Using the chronic variable stress mouse model coupled with RNA sequencing, we identified vitamin B12–induced transcriptional changes related to stress
-
The A53T Mutation in α-Synuclein Enhances Proinflammatory Activation in Human Microglia Upon Inflammatory Stimulus Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-17 Marine Krzisch, Bingbing Yuan, Wenyu Chen, Tatsuya Osaki, Dongdong Fu, Carrie M. Garrett-Engele, Devon S. Svoboda, Kristin R. Andrykovich, Michael D. Gallagher, Mriganka Sur, Rudolf Jaenisch
Parkinson’s disease (PD) is the second most common neurodegenerative disease, following Alzheimer’s. It is characterized by the aggregation of α-synuclein into Lewy bodies and Lewy neurites in the brain. Microglia-driven neuroinflammation may contribute to neuronal death in PD; however, the exact role of microglia remains unclear and has been understudied. The A53T mutation in the gene coding for α-synuclein
-
A Novel Role for the Histone Demethylase JMJD3 in Mediating Heroin-Induced Relapse-Like Behaviors Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-15 Swarup Mitra, Craig T. Werner, Treefa Shwani, Ana Garcia Lopez, Dale Federico, Kate Higdon, Xiaofang Li, Pedro H. Gobira, Shruthi A. Thomas, Jennifer A. Martin, Chunna An, Ramesh Chandra, Ian Maze, Rachel Neve, Mary Kay Lobo, Amy M. Gancarz, David M. Dietz
Epigenetic changes that lead to long-term neuroadaptations following opioid exposure are not well understood. We examined how histone demethylase JMJD3 in the nucleus accumbens (NAc) influences heroin seeking after abstinence from self-administration. Male Sprague Dawley rats were trained to self-administer heroin. Western blotting and quantitative polymerase chain reaction were performed to quantify
-
Role of Prefrontal Cortex Circuitry in Maintaining Social Homeostasis Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-15 SeungHyun Lee, Ziv M. Williams
Homeostasis is a fundamental concept in biology and ensures the stability of life by maintaining the constancy of physiological processes. Recent years have witnessed a surge in research interest in these physiological processes, with a growing focus on understanding the mechanisms underlying social homeostasis. This shift in focus underscores our increasing understanding of the importance of social
-
Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-10 Nathaniel G. Harnett, Leland L. Fleming, Kevin J. Clancy, Kerry J. Ressler, Isabelle M. Rosso
Posttraumatic stress disorder (PTSD) is widely recognized as involving disruption of core neurocircuitry that underlies processing, regulation, and response to threat. In particular, the prefrontal cortex–hippocampal–amygdala circuit is a major contributor to posttraumatic dysfunction. However, the functioning of core threat neurocircuitry is partially dependent on sensorial inputs, and previous research
-
Allostatic Interoceptive Overload Across Psychiatric and Neurological Conditions Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-02 Hernando Santamaría-García, Joaquin Migeot, Vicente Medel, Jessica L. Hazelton, Vanessa Teckentrup, Roman Romero-Ortuno, Olivier Piguet, Brian Lawor, George Northoff, Agustin Ibanez
Emerging theories emphasize the crucial role of allostasis (anticipatory and adaptive regulation of the body’s biological processes) and interoception (integration, anticipation, and regulation of internal bodily states) in adjusting physiological responses to environmental and bodily demands. In this review, we explore the disruptions in integrated allostatic interoceptive mechanisms in psychiatric
-
Prescription Digital Therapeutics: An Emerging Treatment Option for Negative Symptoms in Schizophrenia Biol. Psychiatry (IF 9.6) Pub Date : 2024-07-01 Daniel Fulford, Lisa A. Marsch, Abhishek Pratap
Digital therapeutics—web-based programs, smartphone applications, and wearable devices designed to prevent, treat, or manage clinical conditions through software-driven, evidence-based intervention—can provide accessible alternatives and/or may supplement standard care for patients with serious mental illnesses, including schizophrenia. In this article, we provide a targeted summary of the rapidly
-
Schizophrenia Interactome–Derived Repurposable Drugs and Randomized Controlled Trials of Two Candidates Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-29 Madhavi K. Ganapathiraju, Triptish Bhatia, Smita Deshpande, Maribeth Wesesky, Joel Wood, Vishwajit L. Nimgaonkar
There is a substantial unmet need for effective and patient-acceptable drugs to treat severe mental illnesses such as schizophrenia (SZ). Computational analysis of genomic, transcriptomic, and pharmacologic data generated in the past 2 decades enables repurposing of drugs or compounds with acceptable safety profiles, namely those that are U.S. Food and Drug Administration approved or have reached late
-
The NKCC1 Inhibitor Bumetanide Restores Cortical Feedforward Inhibition and Lessens Sensory Hypersensitivity in Early Postnatal Fragile X Mice Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-29 Nazim Kourdougli, Toshihiro Nomura, Michelle W. Wu, Anouk Heuvelmans, Zoë Dobler, Anis Contractor, Carlos Portera-Cailliau
Exaggerated responses to sensory stimuli, a hallmark of fragile X syndrome, contribute to anxiety and learning challenges. Sensory hypersensitivity is recapitulated in the knockout (KO) mouse model of fragile X syndrome. Recent studies in KO mice have demonstrated differences in the activity of cortical interneurons and a delayed switch in the polarity of GABA (gamma-aminobutyric acid) signaling during
-
Fluoxetine and Ketamine Enhance Extinction Memory and Brain Plasticity by Triggering the p75 Neurotrophin Receptor Proteolytic Pathway Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-28 Cassiano Ricardo Alves Faria Diniz, Ana Paula Crestani, Plinio Cabrera Casarotto, Caroline Biojone, Cecilia Cannarozzo, Frederike Winkel, Mikhail A. Prozorov, Erik F. Kot, Sergey A. Goncharuk, Danilo Benette Marques, Leonardo Rakauskas Zacharias, Henri Autio, Madhusmita Priyadarshini Sahu, Anna Bárbara Borges-Assis, João Pereira Leite, Konstantin S. Mineev, Eero Castrén, Leonardo Barbosa Moraes Resstel
Diverse antidepressants were recently described to bind to TrkB (tyrosine kinase B) and drive a positive allosteric modulation of endogenous BDNF (brain-derived neurotrophic factor). Although neurotrophins such as BDNF can bind to p75NTR (p75 neurotrophin receptor), their precursors are the high-affinity p75NTR ligands. While part of an unrelated receptor family capable of inducing completely opposite
-
Longitudinal Changes in Functional Neural Activation and Sensitization During Face Processing in Fragile X Syndrome Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-28 Yuanyuan Gao, Rihui Li, Qianheng Ma, Kristi L. Bartholomay, Amy A. Lightbody, Allan L. Reiss
Fragile X syndrome (FXS) is a genetic condition associated with increased risk for social anxiety and avoidance. Using functional near-infrared spectroscopy (fNIRS), we previously demonstrated aberrant neural activity responding to faces in young girls with FXS cross-sectionally. Here, we tested the hypothesis that abnormalities in neural activation and sensitization would increase with age in 65 girls
-
Stress and Inflammation Target Dorsolateral Prefrontal Cortex Function: Neural Mechanisms Underlying Weakened Cognitive Control Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-27 Mary Kate P. Joyce, Stacy Uchendu, Amy F.T. Arnsten
Most mental disorders involve dysfunction of the dorsolateral prefrontal cortex (dlPFC), a recently evolved brain region that subserves working memory, abstraction, and the thoughtful regulation of attention, action, and emotion. For example, schizophrenia, depression, long COVID, and Alzheimer’s disease are all associated with dlPFC dysfunction, with neuropathology often being focused in layer III
-
Insomnia Subtypes Have Differentiating Deviations in Brain Structural Connectivity Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-27 Tom Bresser, Tessa F. Blanken, Siemon C. de Lange, Jeanne Leerssen, Jessica C. Foster-Dingley, Oti Lakbila-Kamal, Rick Wassing, Jennifer R. Ramautar, Diederick Stoffers, Martijn P. van den Heuvel, Eus J.W. Van Someren
Insomnia disorder is the most common sleep disorder. A better understanding of insomnia-related deviations in the brain could inspire better treatment. Insufficiently recognized heterogeneity within the insomnia population could obscure detection of involved brain circuits. In the current study, we investigated whether structural brain connectivity deviations differed between recently discovered and
-
The Contribution of Mosaic Chromosomal Alterations to Schizophrenia Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-26 Kaihui Chang, Xuemin Jian, Chuanhong Wu, Chengwen Gao, Yafang Li, Jianhua Chen, Baiqiang Xue, Yonghe Ding, Lixia Peng, Baokun Wang, Lin He, Yifeng Xu, Changgui Li, Xingwang Li, Zhuo Wang, Xiangzhong Zhao, Dun Pan, Qiangzhen Yang, Juan Zhou, Zijia Zhu, Ze Liu, Disong Xia, Guoyin Feng, Qian Zhang, Yanqin Wen, Yongyong Shi, Zhiqiang Li
Mosaic chromosomal alterations are implicated in neuropsychiatric disorders, but the contribution to schizophrenia (SCZ) risk for somatic copy number variations (sCNVs) emerging in early developmental stages has not been fully established. We analyzed blood-derived genotype arrays from 9715 patients with SCZ and 28,822 control participants of Chinese descent using a computational tool (MoChA) based
-
Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-Sensitive Magnetic Resonance Imaging and [18F]-DOPA Positron Emission Tomography Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-26 Luke J. Vano, Robert A. McCutcheon, Grazia Rutigliano, Stephen J. Kaar, Valeria Finelli, Giovanna Nordio, George Wellby, Jan Sedlacik, Ben Statton, Eugenii A. Rabiner, Rong Ye, Mattia Veronese, Seth C. Hopkins, Kenneth S. Koblan, Ian P. Everall, Oliver D. Howes
Striatal hyperdopaminergia is implicated in the pathoetiology of schizophrenia, but how this relates to dopaminergic midbrain activity is unclear. Neuromelanin (NM)-sensitive magnetic resonance imaging provides a marker of long-term dopamine function. We examined whether midbrain NM-sensitive magnetic resonance imaging contrast-to-noise ratio (NM-CNR) was higher in people with schizophrenia than in
-
The Dynamic Interplay Between Puberty and Structural Brain Development as a Predictor of Mental Health Difficulties in Adolescence: A Systematic Review Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-24 Svenja Kretzer, Andrew J. Lawrence, Rebecca Pollard, Xuemei Ma, Pei Jung Chen, Nare Amasi-Hartoonian, Carmine Pariante, Corentin Vallée, Michael Meaney, Paola Dazzan
Puberty is a time of intense reorganization of brain structure and a high-risk period for the onset of mental health problems, with variations in pubertal timing and tempo intensifying this risk. We conducted 2 systematic reviews of articles published up to February 1, 2024, focusing on 1) the role of brain structure in the relationship between puberty and mental health, and 2) precision psychiatry
-
Critically Assessing the Unanswered Questions of How, Where, and When to Induce Plasticity in the Posttraumatic Stress Disorder Network With Transcranial Magnetic Stimulation Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-22 Joshua C. Brown, Jamie Kweon, Prayushi Sharma, Shan H. Siddiqi, Moshe Isserles, Kerry J. Ressler
Extinction of traumatic memory, a primary treatment approach (termed exposure therapy) in posttraumatic stress disorder (PTSD), occurs through relearning and may be subserved at the molecular level by long-term potentiation of relevant circuits. In parallel, repetitive transcranial magnetic stimulation (TMS) is thought to work through long-term potentiation–like mechanisms and may provide a novel,
-
Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated With Psychopathology Across Independent Cohorts Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-21 Haley R. Wang, Zhen-Qi Liu, Hajer Nakua, Catherine E. Hegarty, Melanie Blair Thies, Pooja K. Patel, Charles H. Schleifer, Thomas P. Boeck, Rachel A. McKinney, Danielle Currin, Logan Leathem, Pamela DeRosse, Carrie E. Bearden, Bratislav Misic, Katherine H. Karlsgodt
Patients with early psychosis (EP) (within 3 years after psychosis onset) show significant variability, which makes predicting outcomes challenging. Currently, little evidence exists for stable relationships between neural microstructural properties and symptom profiles across EP diagnoses, which limits the development of early interventions. A data-driven approach, partial least squares correlation
-
A Cocaine-Activated Ensemble Exerts Increased Control Over Behavior While Decreasing in Size Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-18 Kimberly C. Thibeault, Michael Z. Leonard, Veronika Kondev, Soren D. Emerson, Rishik Bethi, Alberto J. Lopez, Jonathon P. Sens, Brett P. Nabit, Hannah B. Elam, Danny G. Winder, Sachin Patel, Drew D. Kiraly, Brad A. Grueter, Erin S. Calipari
Substance use disorder is characterized by long-lasting changes in reward-related brain regions, such as the nucleus accumbens. Previous work has shown that cocaine exposure induces plasticity in broad, genetically defined cell types in the nucleus accumbens; however, in response to a stimulus, only a small percentage of neurons are transcriptionally active—termed an ensemble. Here, we identify an
-
Memory Under Stress: From Adaptation to Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-14 Lars Schwabe
-
The Evolving Landscape of Social Neuroscience and Its Implications for Psychiatry Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-13 S. William Li, Henry W. Kietzman, Jane R. Taylor, Steve W.C. Chang
-
Use of Machine Learning Algorithms Based on Text, Audio, and Video Data in the Prediction of Anxiety and Posttraumatic Stress in General and Clinical Populations: A Systematic Review Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-10 Marketa Ciharova, Khadicha Amarti, Ward van Breda, Xianhua Peng, Rosa Lorente-Català, Burkhardt Funk, Mark Hoogendoorn, Nikolaos Koutsouleris, Paolo Fusar-Poli, Eirini Karyotaki, Pim Cuijpers, Heleen Riper
Research in machine learning (ML) algorithms using natural behavior (i.e., text, audio, and video data) suggests that these techniques could contribute to personalization in psychology and psychiatry. However, a systematic review of the current state of the art is missing. Moreover, individual studies often target ML experts who may overlook potential clinical implications of their findings. In a narrative
-
Dimensional Measures of Psychopathology in Children and Adolescents Using Large Language Models Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-10 Thomas H. McCoy Jr., Roy H. Perlis
To enable greater use of National Institute of Mental Health Research Domain Criteria (RDoC) in real-world settings, we applied large language models (LLMs) to estimate dimensional psychopathology from narrative clinical notes. We conducted a cohort study using health records from individuals age ≤18 years evaluated in the psychiatric emergency department of a large academic medical center between
-
Abnormal Global Cortical Responses in Drug-Naïve Patients With Schizophrenia Following Orbitofrontal Cortex Stimulation: A Concurrent Transcranial Magnetic Stimulation–Electroencephalography Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-08 Xiong Jiao, Qiang Hu, Yingying Tang, Tianhong Zhang, Jie Zhang, Xijin Wang, Junfeng Sun, Jijun Wang
Abnormalities in cortical excitability and plasticity have been considered to underlie the pathophysiology of schizophrenia. Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) can provide a direct evaluation of cortical responses to TMS. Here, we employed TMS-EEG to investigate cortical responses to orbitofrontal cortex (OFC) stimulation in schizophrenia. In total, we
-
Dynamic and Transdiagnostic Risk Calculator Based on Natural Language Processing for the Prediction of Psychosis in Secondary Mental Health Care: Development and Internal-External Validation Cohort Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-07 Kamil Krakowski, Dominic Oliver, Maite Arribas, Daniel Stahl, Paolo Fusar-Poli
Automatic transdiagnostic risk calculators can improve the detection of individuals at risk of psychosis. However, they rely on assessment at a single point in time and can be refined with dynamic modeling techniques that account for changes in risk over time. We included 158,139 patients (5007 events) who received a first index diagnosis of a nonorganic and nonpsychotic mental disorder within electronic
-
Developmental Disruption of Mef2c in Medial Ganglionic Eminence–Derived Cortical Inhibitory Interneurons Impairs Cellular and Circuit Function Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-05 Claire Ward, Kaoutsar Nasrallah, Duy Tran, Ehsan Sabri, Arenski Vazquez, Lucas Sjulson, Pablo E. Castillo, Renata Batista-Brito
is strongly linked to various neurodevelopmental disorders including autism, intellectual disability, schizophrenia, and attention-deficit/hyperactivity disorder. Mice that constitutively lack 1 copy of or selectively lack both copies of in cortical excitatory neurons display a variety of behavioral phenotypes associated with neurodevelopmental disorders. The MEF2C protein is a transcription factor
-
Presynaptic and Postsynaptic Mesolimbic Dopamine D3 Receptors Play Distinct Roles in Cocaine Versus Opioid Reward in Mice Biol. Psychiatry (IF 9.6) Pub Date : 2024-06-03 Zheng-Xiong Xi, Miriam E. Bocarsly, Ewa Galaj, Briana Hempel, Catherine Teresi, Marlisa Shaw, Guo-Hua Bi, Chloe Jordan, Emily Linz, Hannah Alton, Gianluigi Tanda, Zachary Freyberg, Veronica A. Alvarez, Amy Hauck Newman
Past research has illuminated pivotal roles of dopamine D receptors (DR) in the rewarding effects of cocaine and opioids. However, the cellular and neural circuit mechanisms that underlie these actions remain unclear. We employed Cre-LoxP techniques to selectively delete DR from presynaptic dopamine neurons or postsynaptic dopamine D receptor (DR)–expressing neurons in male and female mice. We utilized
-
Anhedonia as a Potential Transdiagnostic Phenotype With Immune-Related Changes in Recent-Onset Mental Health Disorders Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-30 Paris Alexandros Lalousis, Aanya Malaviya, Ali Khatibi, Majid Saberi, Lana Kambeitz-Ilankovic, Shalaila S. Haas, Stephen J. Wood, Nicholas M. Barnes, Jack Rogers, Katharine Chisholm, Alessandro Bertolino, Stefan Borgwardt, Paolo Brambilla, Joseph Kambeitz, Rebekka Lencer, Christos Pantelis, Stephan Ruhrmann, Raimo K.R. Salokangas, Frauke Schultze-Lutter, Andre Schmidt, Eva Meisenzahl, Dominic Dwyer
Chronic low-grade inflammation is observed across mental disorders and is associated with difficult-to-treat-symptoms of anhedonia and functional brain changes, reflecting a potential transdiagnostic dimension. Previous investigations have focused on distinct illness categories in people with enduring illness, but few have explored inflammatory changes. We sought to identify an inflammatory signal
-
Omics Approaches to Investigate the Pathogenesis of Suicide Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-29 Maura Boldrini, Yang Xiao, Tarjinder Sing, Chenxu Zhu, Mbemba Jabbi, Harry Pantazopoulos, Gamze Gürsoy, Keri Martinowich, Giovanna Punzi, Eric J. Vallender, Michael Zody, Sabina Berretta, Thomas M. Hyde, Joel E. Kleinman, Stefano Marenco, Panagiotis Roussos, David A. Lewis, Gustavo Turecki, Thomas Lehner, J. John Mann
Suicide is the second leading cause of death in U.S. adolescents and young adults and is generally associated with a psychiatric disorder. Suicidal behavior has a complex etiology and pathogenesis. Moderate heritability suggests genetic causes. Associations between childhood and recent life adversity indicate contributions from epigenetic factors. Genomic contributions to suicide pathogenesis remain
-
Applying the Research Domain Criteria to Rodent Studies of Sex Differences in Chronic Stress Susceptibility Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-29 Hannah M. Campbell, Jessica D. Guo, Cynthia M. Kuhn
Women have a 2-fold increased rate of stress-associated psychiatric disorders such as depression and anxiety, but the mechanisms that underlie this increased susceptibility remain incompletely understood. Historically, female subjects were excluded from preclinical studies and clinical trials. Additionally, chronic stress paradigms used to study psychiatric pathology in animal models were developed
-
Sex Differences in Stress-Induced Cortisol Response Among Infants of Mothers Exposed to Childhood Adversity Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-29 Korrina A. Duffy, Mary D. Sammel, Rachel L. Johnson, Kathleen E. Morrison, Tracy L. Bale, C. Neill Epperson
Adverse childhood experiences (ACEs) increase risk for mental illness in women and their children, and dysregulation of the hypothalamic-pituitary-adrenal axis may play a role. The impact of ACEs on the hypothalamic-pituitary-adrenal axis may be strongest when ACEs occur prepubertally and in people who are exposed to abuse ACEs. To test this, we measured salivary cortisol in 96 mother-infant dyads
-
New Drug Treatments for Schizophrenia: A Review of Approaches to Target Circuit Dysfunction Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-28 Oliver D. Howes, Eleanor Dawkins, Maria C. Lobo, Stephen J. Kaar, Katherine Beck
Schizophrenia is a leading cause of global disease burden. Current drug treatments are associated with significant side effects and have limited efficacy for many patients, highlighting the need to develop new approaches that target other aspects of the neurobiology of schizophrenia. Preclinical, in vivo imaging, postmortem, genetic, and pharmacological studies have highlighted the key role of cortical
-
Maternal Steroid Hormone Levels in Early Pregnancy and Autism in the Offspring: A Population-Based, Nested Case-Control Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-14 Kyriaki Kosidou, Håkan Karlsson, Stefan Arver, Shalender Bhasin, Christina Dalman, Renée M. Gardner
A role for prenatal steroid hormones in the etiology of autism has been proposed, but evidence is conflicting. Here, we examined serum levels of maternal estradiol, testosterone, 17-hydroxyprogesterone (OHP), and cortisol from the first trimester of gestation (mean = 10.1 weeks) in relation to the odds of diagnosed autism with and without co-occurring intellectual disability (ID) in the offspring ( =
-
Molecular Rhythmicity in Glia: Importance for Brain Health and Relevance to Psychiatric Disease Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-10 Aaron K. Jenkins, Kyle D. Ketchesin, Darius D. Becker-Krail, Colleen A. McClung
Circadian rhythms are approximate 24-hour rhythms present in nearly all aspects of human physiology, including proper brain function. These rhythms are produced at the cellular level through a transcriptional-translational feedback loop known as the molecular clock. Diurnal variation in gene expression has been demonstrated in brain tissue from multiple species, including humans, in both cortical and
-
Intentional Self-Harm and Death by Suicide in Body Dysmorphic Disorder: A Nationwide Cohort Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-09 Daniel Rautio, Kayoko Isomura, Johan Bjureberg, Christian Rück, Paul Lichtenstein, Henrik Larsson, Ralf Kuja-Halkola, Zheng Chang, Brian M. D’Onofrio, Isabell Brikell, Anna Sidorchuk, David Mataix-Cols, Lorena Fernández de la Cruz
Body dysmorphic disorder (BDD) is thought to be associated with considerable suicide risk. This nationwide cohort study quantified the risks of intentional self-harm—including nonsuicidal self-injuries and suicide attempts—and death by suicide in BDD. Individuals with a validated ICD-10 diagnosis of BDD in the Swedish National Patient Register, registered between January 1, 1997, and December 31, 2020
-
Connections Between the Middle Frontal Gyrus and the Dorsoventral Attention Network Are Associated With the Development of Attentional Symptoms Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-06 Yanpei Wang, Leilei Ma, Jiali Wang, Yuyin Ding, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Qi Dong, Sha Tao
The right middle frontal gyrus (MFG) has been proposed as a convergence site for the dorsal attention network (DAN) and ventral attention network (VAN), regulating both networks and enabling flexible modulation of attention. However, it is unclear whether the connections between the right MFG and these networks can predict changes in attention-deficit/hyperactivity disorder (ADHD) symptoms. This study
-
Extrahippocampal Contributions to Social Memory: The Role of Septal Nuclei Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-06 Apoorva Bettagere Shivakumar, Sonam Fathima Mehak, Feyba Jijimon, Gireesh Gangadharan
Social memory, the ability to recognize and remember individuals within a social group, is crucial for social interactions and relationships. Deficits in social memory have been linked to several neuropsychiatric and neurodegenerative disorders. The hippocampus, especially the circuit that links dorsal CA2 and ventral CA1 neurons, is considered a neural substrate for social memory formation. Recent
-
Dimensional Neuroimaging Endophenotypes: Neurobiological Representations of Disease Heterogeneity Through Machine Learning Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-06 Junhao Wen, Mathilde Antoniades, Zhijian Yang, Gyujoon Hwang, Ioanna Skampardoni, Rongguang Wang, Christos Davatzikos
Machine learning has been increasingly used to obtain individualized neuroimaging signatures for disease diagnosis, prognosis, and response to treatment in neuropsychiatric and neurodegenerative disorders. Therefore, it has contributed to a better understanding of disease heterogeneity by identifying disease subtypes with different brain phenotypic measures. In this review, we first present a systematic
-
Circulating Metabolite Abundances Associated With Risks of Bipolar Disorder, Schizophrenia, and Depression: A Mendelian Randomization Study Biol. Psychiatry (IF 9.6) Pub Date : 2024-05-03 Tianyuan Lu, Yiheng Chen, Satoshi Yoshiji, Yann Ilboudo, Vincenzo Forgetta, Sirui Zhou, Celia M.T. Greenwood
Preventive measures and treatments for psychiatric disorders are limited. Circulating metabolites are potential candidates for biomarker and therapeutic target identification, given their measurability and essential roles in biological processes. Leveraging large-scale genome-wide association studies, we conducted Mendelian randomization analyses to assess the associations between circulating metabolite
-
Signature of Altered Retinal Microstructures and Electrophysiology in Schizophrenia Spectrum Disorders Is Associated With Disease Severity and Polygenic Risk Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-27 Emanuel Boudriot, Vanessa Gabriel, David Popovic, Pauline Pingen, Vladislav Yakimov, Sergi Papiol, Lukas Roell, Genc Hasanaj, Simiao Xu, Joanna Moussiopoulou, Siegfried Priglinger, Christoph Kern, Eva C. Schulte, Alkomiet Hasan, Oliver Pogarell, Peter Falkai, Andrea Schmitt, Benedikt Schworm, CDP Working Group, Valéria de Almeida, Stephanie Behrens, Emanuel Boudriot, Mattia Campana, Fanny Dengl, Peter
Optical coherence tomography and electroretinography studies have revealed structural and functional retinal alterations in individuals with schizophrenia spectrum disorders (SSDs). However, it remains unclear which specific retinal layers are affected; how the retina, brain, and clinical symptomatology are connected; and how alterations of the visual system are related to genetic disease risk. Optical
-
An Electroencephalogram Signature of Melanin-Concentrating Hormone Neuron Activities Predicts Cocaine Seeking Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-26 Yao Wang, Danyang Li, Joseph Widjaja, Rong Guo, Li Cai, Rongzhen Yan, Sahin Ozsoy, Giancarlo Allocca, Jidong Fang, Yan Dong, George C. Tseng, Chengcheng Huang, Yanhua H. Huang
Identifying biomarkers that predict substance use disorder propensity may better strategize antiaddiction treatment. Melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus critically mediate interactions between sleep and substance use; however, their activities are largely obscured in surface electroencephalogram (EEG) measures, hindering the development of biomarkers. Surface EEG
-
Extracellular ATP Is a Homeostatic Messenger That Mediates Cell–Cell Communication in Physiological Processes and Psychiatric Diseases Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-26 Yi-Hua Chen, Song Lin, Shi-Yang Jin, Tian-Ming Gao
Neuronal activity is the basis of information encoding and processing in the brain. During neuronal activation, intracellular ATP (adenosine triphosphate) is generated to meet the high-energy demands. Simultaneously, ATP is secreted, increasing the extracellular ATP concentration and acting as a homeostatic messenger that mediates cell–cell communication to prevent aberrant hyperexcitability of the
-
Immune Alterations in the Intrauterine Environment Shape Offspring Brain Development in a Sex-Specific Manner Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-26 Elisa Guma, M. Mallar Chakravarty
Exposure to immune dysregulation in utero or in early life has been shown to increase risk for neuropsychiatric illness. The sources of inflammation can be varied, including acute exposures due to maternal infection or acute stress, or persistent exposures due to chronic stress, obesity, malnutrition, or autoimmune diseases. These exposures may cause subtle alteration in brain development, structure
-
Early Infant Prefrontal Cortical Microstructure Predicts Present and Future Emotionality Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-09 Yicheng Zhang, Layla Banihashemi, Amelia Versace, Alyssa Samolyk, Megan Taylor, Gabrielle English, Vanessa J. Schmithorst, Vincent K. Lee, Richelle Stiffler, Haris Aslam, Ashok Panigrahy, Alison E. Hipwell, Mary L. Phillips
High levels of infant negative emotionality (NE) and low positive emotionality (PE) predict future emotional and behavioral problems. The prefrontal cortex (PFC) supports emotional regulation, with each PFC subregion specializing in specific emotional processes. Neurite orientation dispersion and density imaging estimates microstructural integrity and myelination via the neurite density index (NDI)
-
Lost in Translation: Challenges for Translational Research in the Field of Stress and Cognition Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-05 Israel Liberzon
-
SIRT1 Coordinates Transcriptional Regulation of Neural Activity and Modulates Depression-Like Behaviors in the Nucleus Accumbens Biol. Psychiatry (IF 9.6) Pub Date : 2024-04-03 Hee-Dae Kim, Jing Wei, Tanessa Call, Xiaokuang Ma, Nicole Teru Quintus, Alexander J. Summers, Samantha Carotenuto, Ross Johnson, Angel Nguyen, Yuehua Cui, Jin G. Park, Shenfeng Qiu, Deveroux Ferguson
Major depression and anxiety disorders are significant causes of disability and socioeconomic burden. Despite the prevalence and considerable impact of these affective disorders, their pathophysiology remains elusive. Thus, there is an urgent need to develop novel therapeutics for these conditions. We evaluated the role of SIRT1 in regulating dysfunctional processes of reward by using chronic social
-
Brain Circuit–Derived Biotypes for Treatment Selection in Mood Disorders: A Critical Review and Illustration of a Functional Neuroimaging Tool for Clinical Translation Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-27 Evelyn Jiayi Song, Leonardo Tozzi, Leanne M. Williams
Although the lifetime burden due to major depressive disorder is increasing, we lack tools for selecting the most effective treatments for each patient. One-third to one-half of patients with major depressive disorder do not respond to treatment, and we lack strategies for selecting among available treatments or expediting access to new treatment options. This critical review concentrates on functional
-
Muscarinic Receptor Activators as Novel Treatments for Schizophrenia Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Steven M. Paul, Samantha E. Yohn, Stephen K. Brannan, Nichole M. Neugebauer, Alan Breier
Achieving optimal treatment outcomes for individuals living with schizophrenia remains challenging, despite 70 years of drug development efforts. Many chemically distinct antipsychotics have been developed over the past 7 decades with improved safety and tolerability but with only slight variation in efficacy. All antipsychotics currently approved for the treatment of schizophrenia act as antagonists
-
Reduced Glucocorticoid Responsivity May Represent a Predisposing Marker That Leads to Additional Stress Vulnerability Traits Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Roee Admon
-
The Potential of Genomics and Electronic Health Records to Invigorate Drug Development Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Laurence N. Nisbet, Andrew M. McIntosh
-
Connections From the Central Amygdala to the Bed Nucleus of the Stria Terminalis: The Role in Fear Learning Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-25 Nur Zeynep Güngör
-
Electroconvulsive Therapy Regulates Brain Connectome Dynamics in Patients With Major Depressive Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-21 Yuanyuan Guo, Mingrui Xia, Rong Ye, Tongjian Bai, Yue Wu, Yang Ji, Yue Yu, Gong-Jun Ji, Kai Wang, Yong He, Yanghua Tian
Electroconvulsive therapy (ECT) is an effective treatment for patients with major depressive disorder (MDD), but its underlying neural mechanisms remain largely unknown. The aim of this study was to identify changes in brain connectome dynamics after ECT in MDD and to explore their associations with treatment outcome. We collected longitudinal resting-state functional magnetic resonance imaging data
-
Accelerated Cortical Thinning in Schizophrenia Is Associated With Rare and Common Predisposing Variation to Schizophrenia and Neurodevelopmental Disorders Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-21 Javier González-Peñas, Clara Alloza, Rachel Brouwer, Covadonga M. Díaz-Caneja, Javier Costas, Noemí González-Lois, Ana Guil Gallego, Lucía de Hoyos, Xaquín Gurriarán, Álvaro Andreu-Bernabeu, Rafael Romero-García, Lourdes Fañanás, Julio Bobes, Ana González-Pinto, Benedicto Crespo-Facorro, Lourdes Martorell, Manuel Arrojo, Elisabet Vilella, Alfonso Gutiérrez-Zotes, Marta Perez-Rando, María Dolores Moltó
Schizophrenia is a highly heritable disorder characterized by increased cortical thinning throughout the life span. Studies have reported a shared genetic basis between schizophrenia and cortical thickness. However, no genes whose expression is related to abnormal cortical thinning in schizophrenia have been identified. We conducted linear mixed models to estimate the rates of accelerated cortical
-
Tonic NMDA Receptor Currents in the Brain: Regulation and Cognitive Functions Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-13 Hayoung Kim, Sunyeong Choi, Euisun Lee, Wuhyun Koh, C. Justin Lee
Synaptically localized NMDA receptors (NMDARs) play a crucial role in important cognitive functions by mediating synaptic transmission and plasticity. In contrast, a tonic NMDAR current, thought to be mediated by extrasynaptic NMDARs, has a less clear function. This review provides a comprehensive overview of tonic NMDAR currents, focusing on their roles in synaptic transmission/plasticity and their
-
Prefrontal Regulation of Social Behavior and Related Deficits: Insights From Rodent Studies Biol. Psychiatry (IF 9.6) Pub Date : 2024-03-13 Nancy R. Mack, Nadia N. Bouras, Wen-Jun Gao
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing