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The argument framework is a flexible approach to evidence in healthcare Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Jonathan Fuller, Benjamin Chin-Yee, Ross E. G. Upshur
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Bispecific T cell engager therapy for refractory rheumatoid arthritis Nat. Med. (IF 82.9) Pub Date : 2024-04-26 Laura Bucci, Melanie Hagen, Tobias Rothe, Maria Gabriella Raimondo, Filippo Fagni, Carlo Tur, Andreas Wirsching, Jochen Wacker, Artur Wilhelm, Jean-Philippe Auger, Milena Pachowsky, Markus Eckstein, Stefano Alivernini, Angelo Zoli, Gerhard Krönke, Stefan Uderhardt, Aline Bozec, Maria-Antonietta D’Agostino, Georg Schett, Ricardo Grieshaber-Bouyer
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When I use a word . . . The languages of medicines—British Approved Names BMJ (IF 105.7) Pub Date : 2024-04-26 Jeffrey K Aronson
Approved names of medicines, later known as British Approved Names, were introduced in the UK in the 1940s, as part of wartime efforts to ensure the supply of important medicines, including antimalarial drugs manufactured in Germany. Giving them approved names allowed any manufacturer to market a product containing the medicine, which would otherwise only be available as a branded product. Such products
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It’s early days in the collaborative process of reforming medical education and training BMJ (IF 105.7) Pub Date : 2024-04-25 Colin Melville
Oliver and Vaughan outline their concerns about the General Medical Council’s vision for reforming education and training.1 They focused on the areas of change we set out, but ignored the principles that underpin our regulatory approach—patient safety; maintaining standards; outcomes, not time; competency; proportionality; and support for diversity. By not taking these into account they misunderstand
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Medscape caves in on courses funded by tobacco giant Philip Morris, while medics fear global push into medical education BMJ (IF 105.7) Pub Date : 2024-04-26 Hristio Boytchev
Clinic demonstrations, podcasts, and TV shows: Hristio Boytchev reveals how an ambitious deal between a leading medical education provider and the tobacco industry collapsed this week The medical education provider Medscape has bowed to pressure and agreed to permanently remove a series of accredited medical education courses on smoking cessation funded by the tobacco industry giant Philip Morris International
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Stop tobacco industry sponsorship of continuing medical education BMJ (IF 105.7) Pub Date : 2024-04-26 Ruth E Malone
This malign industry must not be allowed to influence clinicians’ learning In a troubling development for tobacco control, Medscape, a continuing education website for health professionals, was recently discovered to be promoting a series on smoking cessation sponsored by tobacco company Philip Morris International (PMI).1 Observers will note the bizarre incongruity of education programmes for doctors
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Achieving more equitable access to assisted reproduction BMJ (IF 105.7) Pub Date : 2024-04-26 Silke J Dyer, G David Adamson, Marcia C Inhorn, Fernando Zegers-Hochschild
Equitable access to fertility care must be recognised as a human right so that it can be better balanced with other societal needs, say Silke Dyer , David Adamson , Marcia Inhorn, and Fernando Zegers-Hochschild Infertility affects one in six people in their lifetime yet remains a neglected global health problem.1 The World Health Organization (WHO) recognises infertility as a disease and has highlighted
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The Public Good on the Docket — The Supreme Court’s Evolving Approach to Public Health N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Joshua M. Sharfstein, and Lawrence O. Gostin From the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore (J.M.S.), and the O’Neill Institute for National and Global Health Law, Georgetown University Law Center, Washington, DC (L.O.G.).
The Supreme Court has imposed new legal principles that impede the ability of states, Congress, and agencies to use evidence to protect the public. It now has the opportunity to reconsider this app...
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Reproductive rights in the United States: acquiescence is not a strategy Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Laura J. Esserman, Douglas Yee
Scientific and medical conferences should not be held in states that ban abortion, as such bans put the lives of women at risk.
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Large language models for preventing medication direction errors in online pharmacies Nat. Med. (IF 82.9) Pub Date : 2024-04-25 Cristobal Pais, Jianfeng Liu, Robert Voigt, Vin Gupta, Elizabeth Wade, Mohsen Bayati
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Urgent action is needed to confront artemisinin partial resistance in African malaria parasites Nat. Med. (IF 82.9) Pub Date : 2024-04-25
Discover the world’s best science and medicine | Nature.com
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Welcoming the Era of Gene Editing in Medicine N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 George Q. Daley From Boston Children’s Hospital and Harvard Medical School — both in Boston.
Recent approvals of exa-cel for treatment of sickle cell disease and transfusion-dependent β-thalassemia mark the dawn of the era of gene editing in medicine. But ensuring access will be challenging.
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Extending Gene Medicines to All in Need N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Joseph M. McCune, and Hans-Peter Kiem From the Global Health Division, Bill and Melinda Gates Foundation (J.M.M.), and the Fred Hutchinson Cancer Center and University of Washington School of Medicine (H.-P.K.) — all in Seattle.
Sixty years ago, Fessas and Stamatoyannopoulos noticed that patients with hereditary persistence of fetal hemoglobin have a milder course of β-thalassemia than other patients with the condition.1 L...
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Specificity of CRISPR-Cas9 Editing in Exagamglogene Autotemcel N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Angela Yen, Zachary Zappala, Rebecca S. Fine, and Timothy D. Majarian Vertex Pharmaceuticals, Boston, MA, Parin Sripakdeevong CRISPR Therapeutics, Boston, MA, David Altshuler Vertex Pharmaceuticals, Boston, MA
The autologous cellular therapy exagamglogene autotemcel is generated by editing an erythroid-specific enhancer of BCL11A. Could another site be edited unintentionally? This study gauged the likeli...
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Exagamglogene Autotemcel for Severe Sickle Cell Disease N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Haydar Frangoul, Franco Locatelli, Akshay Sharma, Monica Bhatia, Markus Mapara, Lyndsay Molinari, Donna Wall, Robert I. Liem, Paul Telfer, Ami J. Shah, Marina Cavazzana, Selim Corbacioglu, Damiano Rondelli, Roland Meisel, Laurence Dedeken, Stephan Lobitz, Mariane de Montalembert, Martin H. Steinberg, Mark C. Walters, Michael J. Eckrich, Suzan Imren, Laura Bower, Christopher Simard, Weiyu Zhou, Fengjuan
Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis by means of ex vivo clustered regularly interspaced short palindromic repeats (CRISPR...
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Exagamglogene Autotemcel for Transfusion-Dependent β-Thalassemia N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-24 Franco Locatelli, Peter Lang, Donna Wall, Roland Meisel, Selim Corbacioglu, Amanda M. Li, Josu de la Fuente, Ami J. Shah, Ben Carpenter, Janet L. Kwiatkowski, Markus Mapara, Robert I. Liem, Maria Domenica Cappellini, Mattia Algeri, Antonis Kattamis, Sujit Sheth, Stephan Grupp, Rupert Handgretinger, Puja Kohli, Daoyuan Shi, Leorah Ross, Yael Bobruff, Christopher Simard, Lanju Zhang, Phuong Khanh Morrow
Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis through ex vivo clustered regularly interspaced short palindromic repeats (CRISPR)–Ca...
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Age-Related Hearing Loss N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Patrick G. O’Malley, Frank R. Lin From the Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore.
Hearing progressively declines with age, manifesting initially as difficulty understanding speech in background noise and detrimentally affecting social functioning. Strategies and technologies can...
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CAR T-Cells and Safety Signals N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
This podcast episode examines CAR T-cell therapy’s early successes, broader promise, and emerging risks, as the FDA considers reports of occasional secondary cancers.
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Case 13-2024: A 27-Year-Old Man with Leg Weakness N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, Andrew S. Allegretti, Cynthia L. Czawlytko, Nikolaos Stathatos, and Peter M. Sadow From the Departments of Medicine (A.S.A., N.S.), Radiology (C.L.C.), and Pathology (P.M.S.), Massachusetts General Hospital, and the Departments of Medicine
A 27-year-old man presented with weight loss, diarrhea, tremor, and proximal muscle weakness. The blood level of potassium was 1.8 mmol per liter. A diagnosis was made.
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Drug-Induced Oxidative Hemolysis N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Wing Kit Lam, and Sze Fai Yip Tuen Mun Hospital, Hong Kong, China
A 57-year-old woman presented with a 3-day history of shortness of breath and dizziness. Laboratory studies showed severe anemia with hemolysis, along with cellular abnormalities in peripheral blood.
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CAR as Booster to Launch Allogeneic Transplantation in Refractory Leukemia N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Didier Blaise From the Department of Hematology, Transplant and Cellular Immunotherapy Program, Institut Paoli Calmettes, Management Sport Cancer laboratory, Aix-Marseille University, Marseille, France.
Chimeric antigen receptor (CAR) T-cell therapies have revolutionized the treatment landscape for patients with relapsed or refractory B-cell lymphoid cancers.1 With studies showing that more than 5...
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Oral Simnotrelvir for Adult Patients with Mild-to-Moderate Covid-19 N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
To the Editor: Cao et al. (Jan. 18 issue)1 evaluated changes in log10 copies of SARS-CoV-2 RNA per milliliter in adults with mild-to-moderate Covid-19 receiving simnotrelvir or placebo. However, on...
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Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
To the Editor: Baris Feldman et al. (Nov. 2 issue)1 describe two siblings with biallelic loss-of-function (Met229Aspfs*16) variants in CORIN and hypertension, atrial fibrillation, atrial fibrosis, ...
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Buprenorphine Dispensing after Elimination of the Waiver Requirement N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Kao-Ping Chua, Mark C. Bicket, and Amy S.B. Bohnert University of Michigan Medical School, Ann Arbor, MI, Rena M. Conti Boston University Questrom School of Business, Boston, MA, Pooja Lagisetty University of Michigan Medical School, Ann Arbor, MI, Thuy D. Nguyen University of Michigan School of Public Health, Ann Arbor, MI
In the year after the elimination of a waiver requirement to prescribe buprenorphine, the number of prescribers increased above the anticipated value, but the number of persons who received the dru...
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Skin Antisepsis before Surgical Fracture Fixation N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
To the Editor: In the PREPARE trial conducted by the PREP-IT investigators, Sprague and colleagues (Feb. 1 issue)1 found a protective effect of skin antisepsis with iodine povacrylex as compared wi...
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Two Randomized Trials of Low-Dose Calcium Supplementation in Pregnancy N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25
To the Editor: The noninferiority trials of high-dose and low-dose calcium supplementation that were reported by Dwarkanath et al. (Jan. 11 issue)1 were premised on the assumption that high-dose ca...
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Nutritional Support for Moderate-to-Late–Preterm Infants — A Randomized Trial N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Tanith Alexander, Sharin Asadi, Michael Meyer, Jane E. Harding, Yannan Jiang, Jane M. Alsweiler, Mariana Muelbert, and Frank H. Bloomfield the DIAMOND Trial Group* From Liggins Institute (T.A., S.A., J.E.H., M. Muelbert, F.H.B.), the Department of Statistics, Faculty of Science (Y.J.), and the Department of Paediatrics, Child and Youth Health (J.M.A.), University of Auckland, and the Neonatal Unit
Most moderate-to-late–preterm infants need nutritional support until they are feeding exclusively on their mother’s breast milk. Evidence to guide nutrition strategies for these infants is lacking....
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Sequential CD7 CAR T-Cell Therapy and Allogeneic HSCT without GVHD Prophylaxis N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-25 Yongxian Hu, Mingming Zhang, Tingting Yang, Zhuomao Mo, Guoqing Wei, Ruirui Jing, Houli Zhao, Rongrong Chen, Cheng Zu, Tianning Gu, Pingnan Xiao, Ruimin Hong, Jingjing Feng, Shan Fu, Delin Kong, Huijun Xu, Jiazhen Cui, Simao Huang, Bin Liang, Xiaolin Yuan, Qu Cui, Hongshan Guo, Yunxian Yu, Youqin Feng, Chunxiang Jin, Jiangtao Ren, Alex H. Chang, Dongrui Wang, and He Huang From the Bone Marrow Transplantation
Patients with relapsed or refractory hematologic cancers have a poor prognosis. Chimeric antigen receptor (CAR) T-cell therapy as a bridge to allogeneic hematopoietic stem-cell transplantation (HSC...
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Prenatal opioid exposure and subsequent risk of neuropsychiatric disorders in children: nationwide birth cohort study in South Korea BMJ (IF 105.7) Pub Date : 2024-04-24 Jiseung Kang, Hyeon Jin Kim, Tae Kim, Hyeri Lee, Minji Kim, Seung Won Lee, Min Seo Kim, Ai Koyanagi, Lee Smith, Guillaume Fond, Laurent Boyer, Masoud Rahmati, Guillermo F López Sánchez, Elena Dragioti, Samuele Cortese, Jae Il Shin, Dong Keon Yon, Marco Solmi
Objective To investigate the potential association between prenatal opioid exposure and the risk of neuropsychiatric disorders in children. Design Nationwide birth cohort study. Setting From 1 January 2009 to 31 December 2020, birth cohort data of pregnant women in South Korea linked to their liveborn infants from the National Health Insurance Service of South Korea were collected. Participants All
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Effect of combination treatment with glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors on incidence of cardiovascular and serious renal events: population based cohort study BMJ (IF 105.7) Pub Date : 2024-04-25 Nikita Simms-Williams, Nir Treves, Hui Yin, Sally Lu, Oriana Yu, Richeek Pradhan, Christel Renoux, Samy Suissa, Laurent Azoulay
Objective To determine whether the combined use of glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors is associated with a decreased risk of major adverse cardiovascular events and serious renal events compared with either drug class alone among patients with type 2 diabetes, and to assess the effect of the combination on the individual components
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Pelvic organ prolapse: self-management of pessaries can be a good option BMJ (IF 105.7) Pub Date : 2024-04-25 Helen Saul, Brendan Deeney, Laura Swaithes, Carol Bugge, Suzanne Hagen, Rohna Kearney
Hagen S, Kearney R, Goodman K, et al. Clinical effectiveness of vaginal pessary self-management vs clinic-based care for pelvic organ prolapse (TOPSY): a randomised controlled superiority trial. eClinicalMedicine 2023;66:102326. To read the full NIHR Alert, go to:
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The future health risks of adverse pregnancy outcomes … and other research BMJ (IF 105.7) Pub Date : 2024-04-25 Ann Robinson
Ann Robinson reviews the latest research Pregnancy and childbirth can be worrying times, and the news that adverse pregnancy outcomes are associated with an increased risk of dying younger will ramp up anxiety, but it also offers scope to shift the dial. This national Swedish cohort study of more than two million women found that any of five major adverse pregnancy outcomes (preterm delivery, small
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Clarity in the law is needed to stop physical punishment of children BMJ (IF 105.7) Pub Date : 2024-04-25 Andrew Rowland
Removing the “reasonable punishment” defence and prohibiting corporal punishment of children can help to reduce family violence, says Andrew Rowland In England and Northern Ireland, we have a key opportunity to give children the equal protection from assault that they need, deserve, and are entitled to as a matter of international children’s rights law. A new Royal College of Paediatrics and Child
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The Safety of Rwanda Act: a pointless exercise in performative cruelty BMJ (IF 105.7) Pub Date : 2024-04-25 Martin McKee
Why do politicians have such a low opinion of British people’s compassion to think this policy is a vote winner, asks Martin McKee Late on 22 April 2024 the Safety of Rwanda (Asylum and Immigration) Bill cleared its final stages in the UK parliament.1 Its stated purpose is to enable the government to send migrants who have reached the UK to Rwanda. The bill was deemed necessary because the government’s
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Total anomalous pulmonary venous connection in an adult BMJ (IF 105.7) Pub Date : 2024-04-25 Maithree Mahesh, Venkatakrishnan Ramakumar
This chest radiograph (fig 1, left panel) and reconstructed cardiac computed tomography angiography scan (fig 1, right panel) show a rare example of unobstructed supracardiac total anomalous pulmonary venous connection (TAPVC).1 The patient, a woman in her 30s, presented with worsening dyspnoea, cyanosis, …
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SSRIs and anticoagulants . . . and other stories BMJ (IF 105.7) Pub Date : 2024-04-25 British Medical Journal Publishing Group
SSRIs are among the most frequently prescribed antidepressants, at least in part because of their favourable safety profile. However, serotoninergic mechanisms are involved in haemostasis, and the potential adverse effects of these drugs may have been underestimated. A study used a UK primary care database to compare the risk of major bleeding in people already taking SSRIs who were starting oral anticoagulants
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Patient centred outcomes should be focus of interventions to sustain independence in older people BMJ (IF 105.7) Pub Date : 2024-04-24 Leah A Palapar, Ngaire Kerse
Maintenance of function is increasingly important as populations age. In their systematic review and network meta-analysis of community based complex interventions to sustain independence in older people, Crocker and colleagues investigated which groups of intervention components most likely sustain independence.1 We noted that few of the estimates were significant and that the authors’ interpretations
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Big alcohol: Universities and schools urged to throw out industry-funded public health advice BMJ (IF 105.7) Pub Date : 2024-04-24 Madlen Davies, freelance investigations reporter, Hristio Boytchev, investigations reporter
The long term harms of alcohol are being minimised in industry funded education, find Madlen Davies and Hristio Boytchev Universities and schools are being urged to join a growing movement in Ireland and the UK that seeks to drive out the alcohol industry from any influence on public health advice on drinking. A campaign in Ireland has led to educational programmes funded by the alcohol industry being
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Acute left testicular pain in a child BMJ (IF 105.7) Pub Date : 2024-04-25 Shin Yin Ooi, Timothy Shao Ern Tan
A 10 year old boy presented to the emergency department with a one day history of left testicular pain and swelling. He had no history of scrotal trauma, fever, nausea, abdominal pain, or urinary symptoms. Clinical examination showed a small, tender, palpable nodule at the upper pole of the left testis. Bilateral cremasteric reflexes were present and both testes showed a normal vertical lie. No appreciable
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Reducing the risks of prenatal opioid exposure in children BMJ (IF 105.7) Pub Date : 2024-04-24 Xuerong Wen, Todd Brothers, Kristina E Ward, Stephen Kogut
Exposure to low doses for short periods outside the first trimester appears to not be associated with a substantially increased risk of neuropsychiatric disorders According to 2019 data from the Centers for Disease Control and Prevention, approximately 7% of women in the United States were prescribed opioids during pregnancy.1 Prescription opioid use among pregnant women with private insurance or Medicaid
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Doctors can’t fix the alcohol problem by themselves BMJ (IF 105.7) Pub Date : 2024-04-25 Rebecca Coombes, The BMJ
A decade ago the jurisdiction of England and Wales was on the brink of introducing a policy that would have led to substantial reductions in the harms done by alcohol (doi:10.1136/bmj.f7646).1 Instead, politicians U turned, ignoring strong health advice in favour of protecting industry interests. Other, braver territories, including Ireland and Australian states, brought in minimum unit pricing, and
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Disparities in Mortality by Sexual Orientation in a Large, Prospective Cohort of Female Nurses JAMA (IF 120.7) Pub Date : 2024-04-25 Sarah McKetta, Tabor Hoatson, Landon D. Hughes, Bethany G. Everett, Sebastien Haneuse, S. Bryn Austin, Tonda L. Hughes, Brittany M. Charlton
ImportanceExtensive evidence documents health disparities for lesbian, gay, and bisexual (LGB) women, including worse physical, mental, and behavioral health than heterosexual women. These factors have been linked to premature mortality, yet few studies have investigated premature mortality disparities among LGB women and whether they differ by lesbian or bisexual identity.ObjectiveTo examine differences
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APOL1-Mediated Kidney Disease JAMA (IF 120.7) Pub Date : 2024-04-25 Timothy Hopper, Opeyemi A. Olabisi
This JAMA Insights reviews the origin of APOL1 high-risk genetic variants, defines APOL1-mediated kidney disease, and discusses recommendations for screening and management.
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In Praise of Hospice JAMA (IF 120.7) Pub Date : 2024-04-25 James R. Nicholas
In this narrative medicine essay, a retired physician describes the kindness, companionship, and skill of the hospice workers who helped his wife and him prepare for her death.
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The ever looming shadow of caregiving BMJ (IF 105.7) Pub Date : 2024-04-24 David Kang
David Kang shares what it is like to live with someone with profound autism and the impact this can have on the whole family Our household doesn’t rely on alarm clocks. Instead, it’s the consistent thumping of my 18 year old brother’s foot against the side of his crib that signals 6 am. His profound autism and developmental delay are woven into the fabric of our family’s daily routine, and his silent
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Medicine is designed for righthanded people BMJ (IF 105.7) Pub Date : 2024-04-24 Chloe Milton
Chloe Milton describes the challenges of being left handed in clinical environments that are designed for righthanded use The surgeon glared at me. When I asked what I’d done wrong they replied that they found it “scary” that I’d used the “wrong” hand to cut sutures when assisting in theatre. What’s scary to me is how easily the challenges faced by lefthanded trainees are dismissed—an experience I’ve
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John Launer: Doctors as activists BMJ (IF 105.7) Pub Date : 2024-04-24 John Launer
Doctor activists are in the news. Sarah Benn, a former GP from Birmingham, has had her medical licence suspended for five months after being arrested for taking part in peaceful protests by Just Stop Oil.1 Medical members of the Extinction Rebellion movement have served jail sentences for taking part in peaceful protests about the climate emergency: they now face disciplinary hearings to determine
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Doing more for patients with hearing loss BMJ (IF 105.7) Pub Date : 2024-04-24 Sophie Holloran
Durno and Abioye raise important and poignant points in their articles about communicating with deaf people.12 I agree entirely—we need to do more to ensure that patients who have hearing loss are not disadvantaged when they are using NHS services. During my internal medicine training, I learnt from patients who …
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Lower Gastrointestinal Hemorrhage JAMA (IF 120.7) Pub Date : 2024-04-24 Hira Imran, Jason T. Alexander, Christopher D. Jackson
This JAMA Clinical Guidelines Synopsis summarizes the 2023 American College of Gastroenterology guidelines on management of patients with acute lower gastrointestinal bleeding.
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An electroencephalogram microdisplay to visualize neuronal activity on the brain surface Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-24 Youngbin Tchoe, Tianhai Wu, Hoi Sang U, David M. Roth, Dongwoo Kim, Jihwan Lee, Daniel R. Cleary, Patricia Pizarro, Karen J. Tonsfeldt, Keundong Lee, Po Chun Chen, Andrew M. Bourhis, Ian Galton, Brian Coughlin, Jimmy C. Yang, Angelique C. Paulk, Eric Halgren, Sydney S. Cash, Shadi A. Dayeh
Functional mapping during brain surgery is applied to define brain areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon and electrophysiologist, which can be time-consuming. In addition, the electrode grids that are used to measure brain activity and to identify the boundaries of pathological versus functional
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Antigenic distance between primary and secondary dengue infections correlates with disease risk Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-24 Lin Wang, Angkana T. Huang, Leah C. Katzelnick, Noémie Lefrancq, Ana Coello Escoto, Loréna Duret, Nayeem Chowdhury, Richard Jarman, Matthew A. Conte, Irina Maljkovic Berry, Stefan Fernandez, Chonticha Klungthong, Butsaya Thaisomboonsuk, Piyarat Suntarattiwong, Warunee Vandepitte, Stephen S. Whitehead, Simon Cauchemez, Derek A. T. Cummings, Henrik Salje
Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection even in previously exposed individuals. In addition, for some pathogens, such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease through a mechanism known as antibody-dependent enhancement. However, it remains unclear whether
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Single-cell multiomics guided mechanistic understanding of Fontan-associated liver disease Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-24 Po Hu, Jack Rychik, Juanjuan Zhao, Huajun Bai, Aidan Bauer, Wenbao Yu, Elizabeth B. Rand, Kathryn M. Dodds, David J. Goldberg, Kai Tan, Benjamin J. Wilkins, Liming Pei
The Fontan operation is the current standard of care for single-ventricle congenital heart disease. Individuals with a Fontan circulation (FC) exhibit central venous hypertension and face life-threatening complications of hepatic fibrosis, known as Fontan-associated liver disease (FALD). The fundamental biology and mechanisms of FALD are little understood. Here, we generated a transcriptomic and epigenomic
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The subacromial bursa modulates tendon healing after rotator cuff injury in rats Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-24 Brittany P. Marshall, Beth G. Ashinsky, Xavier E. Ferrer, Jennifer A. Kunes, Astia C. Innis, Andrew J. Luzzi, Lynn Ann Forrester, Kevin G. Burt, Andy J. Lee, Lee Song, Lauren E. Lisiewski, Rajesh K. Soni, Clark T. Hung, William N. Levine, David Kovacevic, Stavros Thomopoulos
Rotator cuff injuries result in more than 500,000 surgeries annually in the United States, many of which fail. These surgeries typically involve repair of the injured tendon and removal of the subacromial bursa, a synovial-like tissue that sits between the rotator cuff and the acromion. The subacromial bursa has been implicated in rotator cuff pathogenesis and healing. Using proteomic profiling of
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New risk score for cardiovascular disease with improved performance Nat. Med. (IF 82.9) Pub Date : 2024-04-23
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Nivolumab for mismatch-repair-deficient or hypermutated gynecologic cancers: a phase 2 trial with biomarker analyses Nat. Med. (IF 82.9) Pub Date : 2024-04-23 Claire F. Friedman, Beryl L. Manning-Geist, Qin Zhou, Tara Soumerai, Aliya Holland, Arnaud Da Cruz Paula, Hunter Green, Melih Arda Ozsoy, Alexia Iasonos, Travis Hollmann, Mario M. Leitao, Jennifer J. Mueller, Vicky Makker, William P. Tew, Roisin E. O’Cearbhaill, Ying L. Liu, Maria M. Rubinstein, Tiffany Troso-Sandoval, Stuart M. Lichtman, Alison Schram, Chrisann Kyi, Rachel N. Grisham, Pamela Causa
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Assessment of diplopia in adults BMJ (IF 105.7) Pub Date : 2024-04-23 Twishaa Sheth, Maneeta Morarji, Imran Jawaid
### What you need to know Double vision, or diplopia, may be the first sign of sight or life threatening pathology. A thorough, accurate first assessment is important for determining the clinical urgency of related pathology and ensuring timely management. Whether diplopia is monocular or binocular will help identify aetiology and determine the urgency of management. Ensure double vision is distinguished
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A new approach to oral health can lead to healthier societies BMJ (IF 105.7) Pub Date : 2024-04-23 Julian Fisher, Cleopatra Matanhire-Zihanzu, Kent Buse
New definitions of oral health provide an opportunity to change mindsets and promote innovation to tackle high levels of unmet needs, but this will only be realised with a radical change in practice, argue Julian Fisher and colleagues More than 3.5 billion people globally suffer from the main oral diseases. These conditions combined have an estimated global prevalence of 45%—higher than any other non-communicable
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Helen Salisbury: Sick notes and a national illness service BMJ (IF 105.7) Pub Date : 2024-04-23 Helen Salisbury
A common complaint about the NHS is that it’s not so much a health service as an illness service and that we’d be a healthier, happier, and richer society if we focused on prevention rather than leaping into action only when people fall ill. There are many analogies, such as not just fishing bodies out of the river but going upstream to find out who’s pushing people in, or building a fence at the top
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AI triage in general practice will remove the crucial human touch BMJ (IF 105.7) Pub Date : 2024-04-23 Anna Wake
Mathew discusses the use of artificial intelligence (AI) to help triage in general practice.1 Our practice started using a human GP to do this. We have a standardised form for the patient to complete which is then looked at and sifted appropriately. Having …
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Standardising antenatal analgesia information BMJ (IF 105.7) Pub Date : 2024-04-23 Adam G Mounce
Kmietowicz reports that women from poorer backgrounds are less likely to have an epidural during labour than women from richer backgrounds, even when it is medically indicated.1 The authors of the study published in Anaesthesia suggest several reasons for the difference in uptake.2 One reason may be knowledge regarding epidural analgesia. During my obstetric anaesthesia rotation …