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Anti-intercellular adhesion molecule 1 monomaintenance therapy induced long-term liver allograft survival without chronic rejection Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-30 Dong Kyu Han, Suk Kyun Hong, Il Hee Yun, Ji-Jing Yan, Jisu Park, Sang Wha Kim, Seung Hyeok Seok, Haeryoung Kim, Gilyong Ji, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh, Jaeseok Yang, Nam-Joon Yi
Calcineurin inhibitors (CNIs) are essential in liver transplantation (LT); however, their long-term use leads to various adverse effects. The anti–intercellular adhesion molecule (ICAM)-1 monoclonal antibody MD3 is a potential alternative to CNI. Despite its promising results with short-term therapy, overcoming the challenge of chronic rejection remains important. Thus, we aimed to investigate the
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Microbiome composition recovery after liver transplantation correlates with initial liver disease severity and antibiotics treatment Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Sara Vega-Abellaneda, Cristina Dopazo, Francisca Yañez, Zaida Soler, Zixuan Xie, Aleix Canalda-Baltrons, Marc Pons-Tarín, Itxarone Bilbao, Chaysavanh Manichanh
Liver transplantation (LT) is crucial for end-stage liver disease, but it is linked to infection risks. Pathobionts, microorganisms potentially harmful under specific conditions, can cause complications posttransplant. Monitoring such pathogens in fecal samples can be challenging and therefore remains underexplored post-LT. This study aimed to analyze the gut microbiome before and after LT, tracking
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Maternal-fetal microchimerism as a durable but finite and replaceable alloantigen reservoir Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Eva M. Gillis-Buck, James M. Gardner
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Xenotransplantation moves toward clinical trials Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Lara C. Pullen PhD
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Total robotic liver transplant: the final frontier of minimally invasive surgery Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Adeel S. Khan, Meranda Scherer, Roheena Panni, Darren Cullinan, Greg Martens, Ivan Kangarga, Christopher R. King, Richard Benzinger, Jason R. Wellen MD, William C. Chapman, Majella B. Doyle
The use of robotic surgery in transplantation is increasing; however, robotic liver transplantation (RLT) remains a challenging undertaking. To our knowledge, this is a report of the first RLT in North America and the first RLT using a whole graft from a deceased donor in the world. This paper describes the preparation leading to the RLT and the surgical technique of the operation. The operation was
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Do you transplant hearts from donation after circulatory determination of death donors? Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-29 Lara C. Pullen PhD
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Type 2 cytokines safeguard against cellular senescence and aging Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Xian C. Li
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Molecular diagnosis of antibody-mediated rejection: Evaluating biopsy-based transcript diagnostics in the presence of donor-specific antibodies but without microvascular inflammation, a single-center descriptive analysis Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Dusan Harmacek, Lukas Weidmann, Kai Castrezana Lopez, Nicolas Schmid, Raphael Korach, Nicola Bortel, Seraina von Moos, Elena Rho, Birgit Helmchen, Ariana Gaspert, Thomas Schachtner
Biopsy-based transcript diagnostics may identify molecular antibody-mediated rejection (AMR) when microvascular inflammation (MVI) is absent. In this single-center cohort, biopsy-based transcript diagnostics were validated in 326 kidney allograft biopsies. A total of 71 histological AMR and 35 T cell–mediated rejection (TCMR) cases were identified as molecular AMR and TCMR in 55% and 63%, respectively
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Differential induction of donor-reactive forkhead box P3+ regulatory T cell via blockade of CD154 vs CD40 Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-27 Danya Liu, Hongmin Yao, Mandy L. Ford
Recently published studies in both murine models and a meta-analysis of non-human primate renal transplant studies showed that anti-CD154 reagents conferred a significant survival advantage over CD40 blockers in both animal models and across multiple organs. Here we sought to compare the induction of donor-reactive forkhead box P3+-induced regulatory T cells (Foxp3 iTreg) in mice treated with anti-CD154
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Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-26 Philip F. Halloran, Katelynn Madill-Thomsen, Arezu Z. Aliabadi-Zuckermann, Martin Cadeiras, Marisa G. Crespo-Leiro, Eugene C. Depasquale, Mario Deng, Johannes Gökler, Shelley Hall, Aayla Jamil, Daniel H. Kim, Jon Kobashigawa, Peter Macdonald, Vojtech Melenovsky, Jignesh Patel, Luciano Potena, Keyur Shah, Josef Stehlik, Andreas Zuckermann
The first-generation Molecular Microscope (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose not only T cell–mediated rejection (TCMR) and antibody-mediated rejection (ABMR) but also acute injury. However, the ideal system should detect rejection without being influenced by injury, to permit analysis of the relationship
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Bridging the critically ill patient with acute to chronic liver failure to liver transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-26 Javier Fernández, Annabel Blasi, Ernest Hidalgo, Constantine J. Karvellas
Liver transplantation (LT) has emerged as an effective therapy for severe forms of acute-on-chronic liver failure (ACLF), an entity characterized by the development of multiorgan failure and high short-term mortality. The aim of critical care management of ACLF patients is to rapidly treat precipitating events and aggressively support failing organs to ensure that patients may successfully undergo
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Validation of a novel donor lung scoring system based on the updated lung Composite Allocation Score Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-24 Zhizhou Yang, Yun Zhu Bai, Yan Yan, Ramsey R. Hachem, Chad A. Witt, Rodrigo Vazquez Guillamet, Derek E. Byers, Gary F. Marklin, Daniel Kreisel, Ruben G. Nava, Bryan F. Meyers, Benjamin D. Kozower, G. Alexander Patterson, Matthew G. Hartwig, Brendan T. Heiden, Varun Puri
Lung transplantation (LTx) continues to have lower rates of long-term graft survival compared with other organs. Additionally, lung utilization rates from brain-dead donors remain substantially lower compared with other solid organs, despite a growing need for LTx and the significant risk of waitlist mortality. This study aims to examine the effects of using a combination of the recently described
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Nanoparticle targeting of neutrophil glycolysis prevents lung ischemia-reperfusion injury Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-24 Fuyi Liao, Davide Scozzi, Dequan Zhou, Mina Maksimos, Camila Diedrich, Marlene Cano, Laneshia K. Tague, Zhyi Liu, Jeffrey A. Haspel, Jennifer M. Leonard, Wenjun Li, Alexander S. Krupnick, Brian W. Wong, Daniel Kreisel, Abdel Kareem Azab, Andrew E. Gelman
Neutrophils exacerbate pulmonary ischemia-reperfusion injury (IRI) resulting in poor short and long-term outcomes for lung transplant recipients. Glycolysis powers neutrophil activation, but it remains unclear if neutrophil-specific targeting of this pathway will inhibit IRI. Lipid nanoparticles containing the glycolysis flux inhibitor 2-deoxyglucose (2-DG) were conjugated to neutrophil-specific Ly6G
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Association of procurement technique with organ yield and cost following donation after circulatory death Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-21 Syed Shahyan Bakhtiyar, Tiffany E. Maksimuk, John Gutowski, Sarah Y. Park, Michael T. Cain, Jessica Y. Rove, T. Brett Reece, Joseph C. Cleveland Jr., James J. Pomposelli, Yanik J. Bababekov, Trevor L. Nydam, Jesse D. Schold, Elizabeth A. Pomfret, Jordan R.H. Hoffman
Donation after circulatory death (DCD) could account for the largest expansion of the donor allograft pool in the contemporary era. However, the organ yield and associated costs of normothermic regional perfusion (NRP) compared to super-rapid recovery (SRR) with ex-situ normothermic machine perfusion, remain unreported. The Organ Procurement and Transplantation Network (December 2019 to June 2023)
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Are the Centers for Medicare & Medicaid Services metrics evaluating organ procurement organization performance too fragile? Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-20 Jesse D. Schold, Rocio Lopez, Sumit Mohan
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Coordinated elimination of bacterial taxa optimally attenuates alloimmunity and prolongs allograft survival Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-20 Martin Sepulveda, Mladen Rasic, Yuk Man Lei, Montserrat Kwan, Luqiu Chen, Yang Chen, David Perkins, Maria-Luisa Alegre
This study aimed to dissect the relationship between specific gut commensal bacterial subgroups, their functional metabolic pathways, and their impact on skin allograft outcome and alloimmunity. We previously showed that oral broad-spectrum antibiotic (Abx) pretreatment in mice delayed skin, heart, and lung allograft rejection and dampened alloimmune responses. Here, rationally designed Abx combinations
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Excess mortality in COVID-19-affected solid organ transplant recipients across the pandemic Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-20 Shigeyoshi Yamanaga, Keita Shimata, Satoko Ohfuji, Mikiko Yoshikawa, Yoichiro Natori, Taizo Hibi, Kenji Yuzawa, Hiroto Egawa, Japan Society for Transplantation COVID-19 Registry Study Group, Kohei Unagami, Hideki Ishida, Kazuya Omoto, Mureo Kasahara, Hajime Uchida, Seisuke Sakamoto, Kenta Futamura, Kenta Nishikawa, Ryoichi Imamura, Shigeaki Nakazawa, Etsuro Hatano, Takashi Ito, Yuki Masano, Morikuni
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on the Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized based on dominant phases of variants of concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha)
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Down to the coronary arteries: When spatial multiomics open up a narrow path Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Alessandro Alessandrini, Ivy A. Rosales
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Myeloid-derived suppressor cells promote allograft survival by suppressing regulatory T cell dysfunction in high-risk corneal transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Seokjoo Lee, Tomas Blanco, Aytan Musayeva, Shima Dehghani, Akitomo Narimatsu, Katayoon Forouzanfar, Gustavo Ortiz, Francesca Kahale, Shudan Wang, Yihe Chen, Thomas H. Dohlman, Sunil K. Chauhan, Reza Dana
Highly inflamed and neovascularized corneal graft beds are known as high-risk (HR) environments for transplant survival. One of the primary factors leading to this rejection is reduction in the suppressive function of regulatory T cells (Treg). Our results show that myeloid-derived suppressor cells (MDSC) counteract interleukin-6–mediated Treg dysfunction by expressing interleukin-10. Additionally
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Should advanced perfusion be the standard of care for donation after circulatory death liver transplant? Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Kristopher P. Croome
As an alternative to static cold storage (SCS), advanced perfusion techniques such as normothermic regional perfusion and ex-situ perfusion (normothermic or hypothermic) have emerged as a way to improve the ischemic injury suffered by donation after circulatory death (DCD) livers. Multiple studies have been published that have demonstrated superior post-DCD liver transplant outcomes when using advanced
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Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-19 Kiran K. Khush, James L. Bernat, Richard N. Pierson III, Henry J. Silverman, Brendan Parent, Alexandra K. Glazier, Andrew B. Adams, Jay A. Fishman, Michael Gusmano, Wayne J. Hawthorne, Mary E. Homan, Daniel J. Hurst, Stephen Latham, Chung-Gyu Park, Karen J. Maschke, Muhammad M. Mohiuddin, Robert A. Montgomery, Jonah Odim, Rebecca D. Pentz, Bruno Reichart, Julian Savulescu, Paul Root Wolpe, Renee P
Xenotransplantation offers the potential to meet the critical need for heart and lung transplantation presently constrained by the current human donor organ supply. Much was learned over the past decades regarding gene editing to prevent the immune activation and inflammation that cause early organ injury, and strategies for maintenance of immunosuppression to promote longer-term xenograft survival
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Untangling genetic and environmental risks in kidney transplant outcomes: The interplay of self-identified race, genetic ancestry, monogenic risk alleles, and socioeconomic factors Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-18 Yasar Caliskan, Krista L. Lentine
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Tiny heroes: Microbiota-modified bile acid metabolites protect against drug-induced gut damage Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-18 Montserrat Kwan, Maria-Luisa Alegre
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Liver machine perfusion technology: Expanding the donor pool to improve access to liver transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-18 Stalin Canizares, Adriana Montalvan, Ritah Chumdermpadetsuk, Anna Modest, Devin Eckhoff, David D. Lee
The imbalance between organ supply and demand continues to limit the broader benefits of organ transplantation. Machine perfusion (MP) may increase the supply of donor livers by expanding the use of extended-criteria donors. Using the United Network for Organ Sharing/Organ Procurement and Transplantation Network and the Standard Transplant Analysis and Research dataset, we reviewed the effect of MP
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Longitudinal outcomes of COVID-19 in solid organ transplant recipients from 2020 to 2023 Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-17 Javier T. Solera, Berta G. Árbol, Ankit Mittal, Victoria Hall, Tina Marinelli, Ilona Bahinskaya, Nazia Selzner, Michael McDonald, Jeffrey Schiff, Aman Sidhu, Atul Humar, Deepali Kumar
Data regarding coronavirus disease 2019 (COVID-19) outcomes in solid organ transplant recipients (SOTr) across severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) waves, including the impact of different measures, are lacking. This cohort study, conducted from March 2020 to May 2023 in Toronto, Canada, aimed to analyze COVID-19 outcomes in 1975 SOTr across various SARS-CoV-2 waves and assess
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Measles outbreak in the United States Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-16 Marcus R. Pereira
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Generating strategies for a national comeback in pancreas transplantation: A Delphi survey and US conference report Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-16 Ronald F. Parsons, Krista L. Lentine, Mona Doshi, Ty B. Dunn, Rachel Forbes, Jonathan A. Fridell, Michelle T. Jesse, Martha Pavlakis, Deirdre Sawinski, Neeraj Singh, David A. Axelrod, Matthew Cooper MD, Workshop Participants
In the United States, potential transplant candidates with insulin-dependent diabetes mellitus are inconsistently offered PTx (pancreas transplantation), contributing to a dramatic decline in pancreas allograft utilization over the past 2 decades. The American Society of Transplantation organized a workshop to identify barriers inhibiting PTx and to develop strategies for a national comeback. The 2-day
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Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-15 Daan Kremer, Tim J. Knobbe, Joanna Sophia J. Vinke, Dion Groothof, Adrian Post, Coby Annema, Alferso C. Abrahams, Brigit C. van Jaarsveld, Martin H. de Borst, Stefan P. Berger, TransplantLines Investigators, Adelta V. Ranchor, Antonio W. Gomes Neto, Arjan Diepstra, Bouke G. Hepkema, C. Tji Gan, Caecilia S.E. Doorenbos, Charlotte A. te Velde-Keyzer, Coretta van Leer-Buter, Daan J. Touw, Eelko Hak, Erik
Kidney transplant recipients (KTRs) experience more fatigue, anxiety, and depressive symptoms and lower concentration and health-related quality of life (HRQoL) compared with the general population. Anemia is a potential cause that is well-recognized and treated. Iron deficiency, however, is often unrecognized, despite its potential detrimental effects related to and unrelated to anemia. We investigated
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The use of extracorporeal photopheresis in solid organ transplantation—current status and future directions Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-14 Markus J. Barten, Andrew J. Fisher, Alexandre Hertig
Prevention and management of allograft rejection urgently require more effective therapeutic solutions. Current immunosuppressive therapies used in solid organ transplantation, while effective in reducing the risk of acute rejection, are associated with substantial adverse effects. There is, therefore, a need for agents that can provide immunomodulation, supporting graft tolerance, while minimizing
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Immunosuppression withdrawal in living-donor renal transplant recipients following induction with antithymocyte globulin and rituximab: Results of a prospective clinical trial Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-11 James F. Markmann, Bryna E. Burrell, Jonathan S. Bromberg, Choli Hartono, Dixon B. Kaufman, Andrew M. Possselt, Ali Naji, Nancy D. Bridges, Cynthia Breeden, Sai Kanaparthi, Jorge Pardo, Heather Kopetskie, Kristen Mason, Noha Lim, Sindhu Chandran
Durable tolerance in kidney transplant recipients remains an important but elusive goal. We hypothesized that adding B cell depletion to T cell depletion would generate an immune milieu postreconstitution dominated by immature transitional B cells, favoring tolerance. The Immune Tolerance Network ITN039ST Research Study of ATG and Rituximab in Renal Transplantation was a prospective multicenter pilot
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Banff 2022 Liver Group Meeting report: Monitoring long-term allograft health Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-09 Christopher O.C. Bellamy, Jacqueline G. O'Leary, Oyedele Adeyi, Nahed Baddour, Ibrahim Batal, John Bucuvalas, Arnaud Del Bello, Mohamed El Hag, Magda El-Monayeri, Alton B. Farris III, Sandy Feng, Maria Isabel Fiel, Sandra E. Fischer, John Fung, Krzysztof Grzyb, Maha Guimei, Hironori Haga, John Hart, Annette M. Jackson, Elmar Jaeckel, Nigar A. Khurram, Stuart J. Knechtle, Drew Lesniak, Josh Levitsky
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations and discussions focused on the evaluation of long-term allograft health, including noninvasive and tissue monitoring, immunosuppression optimization, and long-term structural changes. Potential revision
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Living organ donation in polarized societies Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Eytan Mor
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Morning administration enhances humoral response to SARS-CoV-2 vaccination in kidney transplant recipients Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ivan Zahradka, Filip Tichanek, Maria Magicova, Istvan Modos, Ondrej Viklicky, Vojtech Petr
Although severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid (SARS-CoV-2 mRNA) vaccines are effective in kidney transplant recipients (KTRs), their immune response to vaccination is blunted by immunosuppression. Other tools enhancing vaccination response are therefore needed. Interestingly, aligning vaccine administration with circadian rhythms (chronovaccination) has been shown
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Successful lung transplantation in genetic methionyl-tRNA synthetase–related alveolar proteinosis/lung fibrosis without recurrence under methionine supplementation: Medium-term outcome in 4 cases Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Charlotte Roy, Nathalie Allou, Aurore Coulomb, Dominique Grenet, Raphaël Borie, Benjamin Zuber, Abdulmonem Hamid, Matthieu Glorion, Anne-Laure Brun, Elizabeth Longchamps, Alice Hadchouel, Olivier Brugiere
Pulmonary alveolar proteinosis (PAP) results from the accumulation of lipoproteinaceous material in the alveoli and alveolar macrophages, and can be associated with pulmonary fibrosis, with a need for lung transplantation (LTx). Causes of PAP are autoimmune (90%-95%), secondary (5%), or hereditary (<1%). Patients with hereditary PAP are generally not considered for isolated LTx, due to the high probability
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Racism and tolerance in live kidney donation in Israel—response to Nesher et al Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-08 Ayelet Shai
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Impact of removing donation service area and region from pancreas allocation Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-06 Sarah E. Booker, Katrina Gauntt, Jesse Howell, Joann White, Oyedolamu Olaitan, Rachel C. Forbes
On March 15, 2021, the Organ Procurement and Transplantation Network (OPTN) replaced donation service area (DSA) and OPTN region as units of pancreas (PA) allocation with a 250 nautical mile (NM) circle with proximity points. We analyzed OPTN data for kidney-pancreas (KP) and PA candidates, transplants, and donors in the 2 years pre-policy (March 16, 2019, to March 14, 2021) and post-policy (March
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Incidence and clearance of cervical and anal high-risk human papillomavirus in kidney transplant recipients: Results from a Danish prospective clinical study Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-06 Linea Landgrebe Ring, Helle Kiellberg Larsen, Kirsten Frederiksen, Merete Hædersdal, Søren Schwartz Sørensen, Jesper Hansen Bonde, Louise Thirstrup Thomsen, Susanne K. Kjær
This study investigates the incidence and clearance of cervical and anal high-risk human papillomavirus (hrHPV) infection in kidney transplant recipients (KTRs) compared to immunocompetent controls. During 2016-2017, we enrolled 125 female KTRs and 125 female controls. Liquid-based cervical and anal cytology samples collected at enrollment and follow-up were tested for human papillomavirus (HPV) DNA
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Microbial bile acid metabolite ameliorates mycophenolate mofetil-induced gastrointestinal toxicity through vitamin D3 receptor Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-05 Di Zhang, Wei Lv, Yue Xu, Zijian Zhang, Song Zeng, Weixun Zhang, Lian Gong, Limei Shao, Min Zhang, Tian He, Yingying Liu, Yuxuan Wang, Ling Liu, Xiaopeng Hu
Mycophenolate mofetil (MMF) is one of the most used immunosuppressive drugs in organ transplantation, but frequent gastrointestinal (GI) side effects through unknown mechanisms limit its clinical use. Gut microbiota and its metabolites were recently reported to play a vital role in MMF-induced GI toxicity, but the specific mechanism of how they interact with the human body is still unclear. Here, we
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Tissue-resident memory T cells in human kidney transplants have alloreactive potential Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-04 Daphne M. Hullegie-Peelen, Hector Tejeda-Mora, Marjolein Dieterich, Sebastiaan Heidt, Eric M.J. Bindels, Martin J. Hoogduijn, Dennis A. Hesselink, Carla C. Baan
The extent to which tissue-resident memory T (T) cells in transplanted organs possess alloreactivity is uncertain. This study investigates the alloreactive potential of T cells in kidney explants from 4 patients who experienced severe acute rejection leading to graft loss. Alloreactive T cell receptor (TCR) clones were identified in pretransplant blood samples through mixed lymphocyte reactions, followed
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The impact of induction therapy on the risk of posttransplant lymphoproliferative disorder in adult kidney transplant recipients with donor-recipient serological Epstein-Barr virus mismatch Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-04 Rose Mary Attieh, Hani M. Wadei, Michael A. Mao, Shennen A. Mao, Surakit Pungpapong, C. Burcin Taner, Tambi Jarmi, Wisit Cheungpasitporn, Napat Leeaphorn
Posttransplant lymphoproliferative disorder (PTLD) poses a significant concern in Epstein-Barr virus (EBV)–negative patients transplanted from EBV-positive donors (EBV R-/D+). Previous studies investigating the association between different induction agents and PTLD in these patients have yielded conflicting results. Using the Organ Procurement and Transplant Network database, we identified EBV R-/D+
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Functional maturation and longitudinal imaging of intraportal neonatal porcine islet grafts in genetically diabetic pigs Am. J. Transplant. (IF 8.8) Pub Date : 2024-03-01 Johanna Pilz, Nicol Gloddek, Felix Lindheimer, Magdalena J. Lindner, Daniel Puhr-Westerheide, Muzzafer Ümütlü, Clemens Cyran, Max Seidensticker, Richard Lindner, Martin Kraetzl, Simone Renner, Daphne Merkus, Daniel Teupser, Peter Bartenstein, Sibylle I. Ziegler, Eckhard Wolf, Elisabeth Kemter
Allogeneic intraportal islet transplantation (ITx) has become an established treatment for patients with poorly controlled type 1 diabetes. However, the loss of viable beta-cell mass after transplantation remains a major challenge. Therefore, noninvasive imaging methods for long-term monitoring of the transplant fate are required. In this study, [Ga]Ga-DOTA-exendin-4 positron emission tomography/computed
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OPTN/SRTR 2022 Annual Data Report: Vascularized Composite Allograft Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 J. Andres Hernandez, Jonathan M. Miller, Emmanuel Emovon III, Jesse N. Howell, Guiliano Testa, Ajay K. Israni, Jon J. Snyder, Linda C. Cendales
This year’s chapter on vascularized composite allograft (VCA) encompasses reviews of data collected from 2014 (when VCA was included in the Final Rule) through 2022. The present Annual Data Report shows that the number of VCA recipients in the United States continues to be small and has remained consistent from the prior report. The data continue to be limited by sample size, with trends persistently
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OPTN/SRTR 2022 Annual Data Report: COVID-19 Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Jonathan M. Miller, Yoon Son Ahn, Allyson Hart, Dorry L. Segev, David P. Schladt, Kathryn T. Livelli, Kelsi A. Lindblad, Ajay K. Israni, Jon J. Snyder
This chapter updates the COVID-19 chapter from the 2021 Annual Data Report with trends through November 12, 2022, and introduces trends in recovery and use of organs from donors with a positive COVID-19 test. Posttransplant mortality and graft failure, which remained a concern in all organs at the last report due to the Omicron variant wave, have returned to lower levels in the most recent available
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OPTN/SRTR 2022 Annual Data Report: Deceased Organ Donation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Ajay K. Israni, David A. Zaun, Katrina Gauntt, Cory R. Schaffhausen, Cinthia Lozano, Warren T. McKinney, Jonathan M. Miller, Jon J. Snyder
The Scientific Registry of Transplant Recipients uses data collected by the Organ Procurement and Transplantation Network to calculate metrics such as organs recovered per donor, organs transplanted per donor, and organs recovered for transplant but not transplanted (ie, nonuse). In 2022, there were 14,905 deceased donors, a 7.5% increase from 13,863 in 2021, and this number has been increasing since
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OPTN/SRTR 2022 Annual Data Report: Lung Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Maryam Valapour, Carli J. Lehr, David P. Schladt, Jodi M. Smith, Kaitlin Swanner, Chelsea J. Weibel, Samantha Weiss, Jon J. Snyder
For the first time since the COVID-19 pandemic, the annual number of lung transplants performed in the United States increased. The year 2022, encompassed in this report, marks the last full calendar year where the Lung Allocation Score was used for ranking transplant candidates based on their estimated transplant benefit and donor lung allocation in the United States. In March 2023, a major change
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OPTN/SRTR 2022 Annual Data Report: Heart Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Monica M. Colvin, Jodi M. Smith, Yoon Son Ahn, Dzhuliyana K. Handarova, Alina C. Martinez, Kelsi A. Lindblad, Ajay K. Israni, Jon J. Snyder
The number of heart transplants in the United States has continued to increase. Since 2011, pediatric heart transplants have increased 31.7% to 494 and adult heart transplants have increased 85.8% to 3,668 in 2022. The numbers of new candidates for pediatric and adult heart transplants have also increased, with 703 new pediatric candidates and 4,446 new adult candidates in 2022. Adult heart transplant
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OPTN/SRTR 2022 Annual Data Report: Intestine Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Simon P. Horslen, Yoon Son Ahn, Nicholas L. Wood, Erin M. Schnellinger, Katrina Gauntt, Meghan McDermott
Intestine remains the least frequently transplanted solid organ, although the survival and quality-of-life benefits of transplant to individuals with irreversible intestinal failure have been well demonstrated. The trend seen over the past 15 years of fewer listings and fewer transplants appears to be continuing, most noticeably in infants, children, and adolescents. There were only 146 additions to
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OPTN/SRTR 2022 Annual Data Report: Liver Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Allison J. Kwong, W. Ray Kim, John R. Lake, David P. Schladt, Erin M. Schnellinger, Katrina Gauntt, Meghan McDermott, Samantha Weiss, Dzhuliyana K. Handarova, Jon J. Snyder, Ajay K. Israni
In 2022, liver transplant activity continued to increase in the United States, with an all-time high of 9,527 transplants performed, representing a 52% increase over the past decade (2012-2022). Of these transplants, 8,924 (93.7%) were from deceased donors and 603 (6.3%) were from living donors. Liver transplant recipients were 94.5% adult and 5.5% pediatric. The overall size of the liver transplant
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OPTN/SRTR 2022 Annual Data Report: Pancreas Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Raja Kandaswamy, Peter G. Stock, Jonathan M. Miller, Sarah E. Booker, Joann White, Ajay K. Israni, Jon J. Snyder
The postpandemic recovery did not occur in pancreas transplantation as in other organs. The number of pancreas transplants in the United States decreased to 918 in 2022 from 963 in 2021. The number of simultaneous pancreas-kidney transplants decreased to 810 in 2022 from 820 in 2021, but the largest decrease was in pancreas transplant alone: 62 in 2022 compared with 92 in 2021. Pancreas-after-kidney
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OPTN/SRTR 2022 Annual Data Report: Kidney Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Krista L. Lentine, Jodi M. Smith, Grace R. Lyden, Jonathan M. Miller, Thomas G. Dolan, Keighly Bradbrook, Lindsay Larkin, Kayla Temple, Dzhuliyana K. Handarova, Samantha Weiss, Ajay K. Israni, Jon J. Snyder
The year 2022 had continued successes and challenges for the field of kidney transplantation, as the community adapted to ongoing surges of the COVID-19 pandemic and broader geographic organ distribution. The total number of kidney transplants in the United States reached a record count of 26,309, driven by continued growth in deceased donor kidney transplants (DDKTs). The total number of candidates
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OPTN/SRTR 2022 Annual Data Report: Introduction Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 David P. Schladt, Ajay K. Israni
The presents the status of the solid organ transplant system in the United States from 2011 through 2022. Organ-specific chapters are presented for kidney, pancreas, liver, intestine, heart, and lung transplant. Each organ-specific chapter is organized to present waitlist information, donor information (both deceased and living, as appropriate), transplant information, and patient outcomes. Data pertaining
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Liver disease is changing and transplant oncology is rising to the challenge Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Lara C. Pullen PhD
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The Banff process—Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Michael Mengel, Roslyn B. Mannon, Sandy Feng
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Subsequent kidney transplant after pediatric heart transplant: Prevalence and risk factors Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Lucas D.G. Barrett, Kelli K. Ryckman, Amber M. Goedken, Emily J. Steinbach, Ellen van der Plas, Gary Beasley, Rabia S. Khan, Vernat Exil, David A. Axelrod, Lyndsay A. Harshman
Pediatric heart failure and transplantation carry associated risks for kidney failure and potential need for kidney transplant following pediatric heart transplantation (KT/pHT). This retrospective, United Network of Organ Sharing study of 10,030 pediatric heart transplants (pHTs) from 1987 to 2020 aimed to determine the incidence of waitlisting for and completion of KT/pHT, risk factors for KT/pHT
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Challenging boundaries: Organ transplants from donors with Listeria central nervous system infections Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-29 Richard Lueking, Monica Fung, Elizabeth Ramos-Salazar, Sreelatha Katari, Geoffrey A. Funk, Cameron R. Wolfe, Ricardo M. La Hoz
Pretransplant mortality rates in the US remain high and are connected to effective organ donation and utilization. Thus, there is a need to maximize the utilization of available donors. In some cases, this has been safely achieved using organs from donors with infectious complications. For example, several studies describe the use of organs from donors with bacterial meningitis due to pathogens such
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Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-28 Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih-Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim
In living-donor liver transplantation, biliary complications including bile leaks and biliary anastomotic strictures remain significant challenges, with incidences varying across different centers. This multicentric retrospective study (2016-2020) included 3633 adult patients from 18 centers and aimed to identify risk factors for these biliary complications and their impact on patient survival. Incidences
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Reevaluating severe acute respiratory syndrome coronavirus-2 donor testing policies: Balancing safety and efficiency in organ transplantation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-27 Stephanie M. Pouch, Ricardo M. La Hoz
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Excess waitlist mortality among candidates for multivisceral liver-intestine transplant in acuity circle allocation Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-24 Allison J. Kwong, Erin Schnellinger, Julia Foutz, Matt Cafarella, Shunji Nagai, Scott W. Biggins, James Pomposelli, James Trotter
Candidates for multivisceral transplant (MVT) have experienced decreased access to transplant in recent years. Using Organ Procurement and Transplantation Network data, transplant and waiting list outcomes for MVT (ie, liver-intestine, liver-intestine-pancreas, and liver-intestine-kidney-pancreas) candidates listed between February 4, 2018, and February 3, 2022, were analyzed, including model for end-stage
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Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Krista Moore, Ebbing Lautenbach, Emily A. Blumberg, Jennifer Han, Dong Heun Lee, Heather Clauss, Richard Hasz, Warren B. Bilker, Esther Molnar, Darcy Alimenti, Sharon West, Pam Tolomeo, Judith A. Anesi
With the increasing prevalence of marijuana use in the US, many deceased organ donors have a history of marijuana use, raising concerns about infectious risks to transplant recipients. We performed a multicenter retrospective cohort study in which exposed donors were those with recent marijuana use (in the prior 12 months) and unexposed donors were those with no recent marijuana use. Primary outcomes
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Fibrotic progression from acute cellular rejection is dependent on secondary lymphoid organs in a mouse model of chronic lung allograft dysfunction Am. J. Transplant. (IF 8.8) Pub Date : 2024-02-23 Katsutaka Mineura, Satona Tanaka, Yasufumi Goda, Yuriko Terada, Akihiko Yoshizawa, Keisuke Umemura, Atsuyasu Sato, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Toshi Mennju, Daniel Kreisel, Hiroshi Date
Chronic lung allograft dysfunction (CLAD) remains one of the major limitations to long-term survival after lung transplantation. We modified a murine model of CLAD and transplanted left lungs from BALB/c donors into B6 recipients that were treated with intermittent cyclosporine and methylprednisolone postoperatively. In this model, the lung allograft developed acute cellular rejection on day 15 which