Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-09-19
Tove Freiburghaus, Daria Pawlik, Kevin Oliveira Hauer, Rik Ossenkoppele, Olof Strandberg, Antoine Leuzy, Jonathan Rittmo, Cécilia Tremblay, Geidy E. Serrano, Michael J. Pontecorvo, Thomas G. Beach, Ruben Smith, Oskar Hansson
Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-09-16
Mónica Zufiría, Oihane Pikatza-Menoio, Maddi Garciandia-Arcelus, Xabier Bengoetxea, Andrés Jiménez, Amaia Elicegui, María Levchuk, Olatz Arnold-García, Jon Ondaro, Pablo Iruzubieta, Laura Rodríguez-Gómez, Uxoa Fernández-Pelayo, Mikel Muñoz-Oreja, Ana Aiastui, José Manuel García-Verdugo, Vicente Herranz-Pérez, Miren Zulaica, Juan José Poza, Rebeca Ruiz-Onandi, Roberto Fernández-Torrón, Juan Bautista
Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-09-10
Lotte Stegat, Alicia Eckhardt, Antonia Gocke, Sina Neyazi, Lara Pohl, Simone Schmid, Matthias Dottermusch, Stephan Frank, Hans Pinnschmidt, Jochen Herms, Markus Glatzel, Matija Snuderl, Leonille Schweizer, Christian Thomas, Julia Neumann, Mario M. Dorostkar, Ulrich Schüller, Annika K. Wefers
HOXD12 defines an age-related aggressive subtype of oligodendroglioma
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-09-11
Nicholas Nuechterlein, Sadie Cimino, Allison Shelbourn, Vinny Ha, Sonali Arora, Sharika Rajan, Linda G. Shapiro, Eric C. Holland, Kenneth Aldape, Tresa McGranahan, Mark R. Gilbert, Patrick J. Cimino
Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer’s disease continuum
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-09-03
Amanda E. Denning, Ranjit Ittyerah, Lisa M. Levorse, Niyousha Sadeghpour, Chinmayee Athalye, Eunice Chung, Sadhana Ravikumar, Mengjin Dong, Michael Tran Duong, Yue Li, Ademola Ilesanmi, Lasya P. Sreepada, Philip Sabatini, MaKayla Lowe, Alejandra Bahena, Jamila Zablah, Barbara E. Spencer, Ryohei Watanabe, Boram Kim, Maja Højvang Sørensen, Pulkit Khandelwal, Christopher Brown, Stanislau Hrybouski, Sharon
Novel mutation of SMPX-related scapuloperoneal myopathy and myofibrillar myopathy
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-09-04
Zhenyu Li, Xujun Chu, Yize Li, Zhiying Xie, Meng Yu, Jianwen Deng, He Lv, Wei Zhang, Zhaoxia Wang, Yun Yuan, Lingchao Meng
PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer’s disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-29
Sophie Schröder, Ulrike Fuchs, Verena Gisa, Tonatiuh Pena, Dennis M. Krüger, Nina Hempel, Susanne Burkhardt, Gabriela Salinas, Anna-Lena Schütz, Ivana Delalle, Farahnaz Sananbenesi, Andre Fischer
Correlation between natural history and multi-omics profiling of meningiomas in NF2-related schwannomatosis suggests role of methylation group and immune microenvironment in tumor growth rate
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-27
Yu Teranishi, Andrey Yurchenko, Suzanne Tran, Philipp Sievers, Fatemeh Rajabi, Singhabahu Ruchith, Samiya Abi-Jaoude, Antoine Blouin, Franck Bielle, Dominique Cazals-Hatem, Felix Sahm, Sergey Nikolaev, Michel Kalamarides, Matthieu Peyre
Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-23
Yiyi Ma, Dolly Reyes-Dumeyer, Angel Piriz, Patricia Recio, Diones Rivera Mejia, Martin Medrano, Rafael A. Lantigua, Jean Paul G. Vonsattel, Giuseppe Tosto, Andrew F. Teich, Benjamin Ciener, Sandra Leskinen, Sharanya Sivakumar, Michael DeTure, Duara Ranjan, Dennis Dickson, Melissa Murray, Edward Lee, David A. Wolk, Lee-Way Jin, Brittany N. Dugger, Annie Hiniker, Robert A. Rissman, Richard Mayeux, Badri
FGFR1 wild-type rosette-forming glioneuronal tumours
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-21
Mégane Le Quang, Aude Trinquet, Aurore Siegfried, Amaury de Barros, Luc Bauchet, Sam Ng, Vincent Jecko, Guillaume Chotard, Morgan Ollivier, Gilles Adam, Fabrice Bonneville, Julien Masliah-Planchon, Yvan Nicaise, Clémentine Decamps, Valérie Rigau, Emmanuelle Uro-Coste
Neuropathological hallmarks in the post-mortem retina of neurodegenerative diseases
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-19
Frederique J. Hart de Ruyter, Manon J. A. P. Evers, Tjado H. J. Morrema, Anke A. Dijkstra, Jurre den Haan, Jos W. R. Twisk, Johannes F. de Boer, Philip Scheltens, Femke H. Bouwman, Frank D. Verbraak, Annemieke J. Rozemuller, Jeroen J. M. Hoozemans
Cryo-EM structures of cotton wool plaques’ amyloid β and of tau filaments in dominantly inherited Alzheimer disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-15
Md Rejaul Hoq, Anllely Fernandez, Frank S. Vago, Grace I. Hallinan, Sakshibeedu R. Bharath, Daoyi Li, Kadir A. Ozcan, Holly J. Garringer, Wen Jiang, Ruben Vidal, Bernardino Ghetti
Microglia contribute to polyG-dependent neurodegeneration in neuronal intranuclear inclusion disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-16
Shaoping Zhong, Yangye Lian, Binbin Zhou, Ruiqing Ren, Lewei Duan, Yuyin Pan, Yuchen Gong, Xiaoling Wu, Dengfeng Cheng, Puming Zhang, Boxun Lu, Xin Wang, Jing Ding
ASXL1 inactivation and reduced H3K27me3 across central nervous system tumors
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-14
Kevin Y. Zhang, Megan Parker, Carly Weber-Levine, Anita Kalluri, Ignacio Gonzalez-Gomez, Eric Raabe, Jonathan C. Dudley, Christopher Gocke, Ming-Tseh Lin, Ying Zou, Mohamed Sherief, David O. Kamson, Matthias Holdhoff, Debraj Mukherjee, Victoria Croog, Karisa C. Schreck, Jordina Rincon-Torroella, Chetan Bettegowda, Charles G. Eberhart, Tejus Bale, Calixto-Hope G. Lucas
Loss over 5% of chromosome 1p is a clinically relevant and applicable cut-off for increased risk of recurrence in meningioma
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-08
Sybren L. N. Maas, Thomas Hielscher, Philipp Sievers, Volker Hovestadt, Abigail K. Suwala, Till Acker, Michael Weller, Matthias Preusser, Christel Herold-Mende, Wolfgang Wick, Andreas von Deimling, Natalie Berghaus, Felix Sahm
Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-06
Melissa J. Alldred, Harshitha Pidikiti, Kyrillos W. Ibrahim, Sang Han Lee, Adriana Heguy, Gabriel E. Hoffman, Panos Roussos, Thomas Wisniewski, Jerzy Wegiel, Grace E. Stutzmann, Elliott J. Mufson, Stephen D. Ginsberg
Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-05
Nur Jury-Garfe, Javier Redding-Ochoa, Yanwen You, Pablo Martínez, Hande Karahan, Enrique Chimal-Juárez, Travis S. Johnson, Jie Zhang, Susan Resnick, Jungsu Kim, Juan C. Troncoso, Cristian A. Lasagna-Reeves
The parkin V380L variant is a genetic modifier of Machado–Joseph disease with impact on mitophagy
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-08-01
Jonasz J. Weber, Leah Czisch, Priscila Pereira Sena, Florian Fath, Chrisovalantou Huridou, Natasa Schwarz, Rana D. Incebacak Eltemur, Anna Würth, Daniel Weishäupl, Miriam Döcker, Gunnar Blumenstock, Sandra Martins, Jorge Sequeiros, Guy A. Rouleau, Laura Bannach Jardim, Maria-Luiza Saraiva-Pereira, Marcondes C. França, Carlos R. Gordon, Roy Zaltzman, Mario R. Cornejo-Olivas, Bart P. C. van de Warrenburg
Diffuse, IDH-wildtype gliomas in adults with minimal histological change and isolated TERT promoter mutation: not simply CNS WHO grade 4
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-29
L. P. Priesterbach-Ackley, F. Cordier, P. de Witt Hamer, T. J. Snijders, P. A. Robe, B. Küsters, W. W. J. de Leng, W. F. A. den Dunnen, D. Brandsma, C. Jansen, P. Wesseling, A. Muhlebner
High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-25
Marius Schwabenland, Dilara Hasavci, Sibylle Frase, Katharina Wolf, Nikolaus Deigendesch, Joerg M. Buescher, Kirsten D. Mertz, Benjamin Ondruschka, Hermann Altmeppen, Jakob Matschke, Markus Glatzel, Stephan Frank, Robert Thimme, Juergen Beck, Jonas A. Hosp, Thomas Blank, Bertram Bengsch, Marco Prinz
Neuropathologically directed profiling of PRNP somatic and germline variants in sporadic human prion disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-24
Gannon A. McDonough, Yuchen Cheng, Katherine S. Morillo, Ryan N. Doan, Zinan Zhou, Connor J. Kenny, Aaron Foutz, Chae Kim, Mark L. Cohen, Brian S. Appleby, Christopher A. Walsh, Jiri G. Safar, August Yue Huang, Michael B. Miller
Differences in the cerebral amyloid angiopathy proteome in Alzheimer’s disease and mild cognitive impairment
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-22
Dominique Leitner, Tomas Kavanagh, Evgeny Kanshin, Kaleah Balcomb, Geoffrey Pires, Manon Thierry, Jianina I. Suazo, Julie Schneider, Beatrix Ueberheide, Eleanor Drummond, Thomas Wisniewski
Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-18
Amal Kasri, Elena Camporesi, Eleni Gkanatsiou, Susana Boluda, Gunnar Brinkmalm, Lev Stimmer, Junyue Ge, Jörg Hanrieder, Nicolas Villain, Charles Duyckaerts, Yannick Vermeiren, Sarah E. Pape, Gaël Nicolas, Annie Laquerrière, Peter Paul De Deyn, David Wallon, Kaj Blennow, Andre Strydom, Henrik Zetterberg, Marie-Claude Potier
Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations.
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-18
Philipp Sievers,Franck Bielle,Kirsten Göbel,Daniel Schrimpf,Lucia Nichelli,Bertrand Mathon,Romain Appay,Henning B Boldt,Hildegard Dohmen,Carmen Selignow,Till Acker,Ales Vicha,Horacio Martinetto,Leonille Schweizer,Ulrich Schüller,Sebastian Brandner,Pieter Wesseling,Simone Schmid,David Capper,Zied Abdullaev,Kenneth Aldape,Andrey Korshunov,Sandro M Krieg,Wolfgang Wick,Stefan M Pfister,Andreas von Deimling
Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-16
Timothy E. Richardson, Jamie M. Walker, Dolores Hambardzumyan, Steven Brem, Kimmo J. Hatanpaa, Mariano S. Viapiano, Balagopal Pai, Melissa Umphlett, Oren J. Becher, Matija Snuderl, Samuel K. McBrayer, Kalil G. Abdullah, Nadejda M. Tsankova
Anti-Ku + myositis: an acquired inflammatory protein-aggregate myopathy
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-16
Marie-Therese Holzer, Akinori Uruha, Andreas Roos, Andreas Hentschel, Anne Schänzer, Joachim Weis, Kristl G. Claeys, Benedikt Schoser, Federica Montagnese, Hans-Hilmar Goebel, Melanie Huber, Sarah Léonard-Louis, Ina Kötter, Nathalie Streichenberger, Laure Gallay, Olivier Benveniste, Udo Schneider, Corinna Preusse, Martin Krusche, Werner Stenzel
DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: a cross-comparative investigation
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-12
Megha Murthy, Katherine Fodder, Yasuo Miki, Naiomi Rambarack, Eduardo De Pablo Fernandez, Lasse Pihlstrøm, Jonathan Mill, Thomas T. Warner, Tammaryn Lashley, Conceição Bettencourt
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-09
Feizhi Song, Valerija Kovac, Behnam Mohammadi, Jessica L. Littau, Franka Scharfenberg, Andreu Matamoros Angles, Ilaria Vanni, Mohsin Shafiq, Leonor Orge, Giovanna Galliciotti, Salma Djakkani, Luise Linsenmeier, Maja Černilec, Katrina Hartman, Sebastian Jung, Jörg Tatzelt, Julia E. Neumann, Markus Damme, Sarah K. Tschirner, Stefan F. Lichtenthaler, Franz L. Ricklefs, Thomas Sauvigny, Matthias Schmitz
Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-07-09
Haoshen Shi, Nazanin Mirzaei, Yosef Koronyo, Miyah R. Davis, Edward Robinson, Gila M. Braun, Ousman Jallow, Altan Rentsendorj, V. Krishnan Ramanujan, Justyna Fert-Bober, Andrei A. Kramerov, Alexander V. Ljubimov, Lon S. Schneider, Warren G. Tourtellotte, Debra Hawes, Julie A. Schneider, Keith L. Black, Rakez Kayed, Maj-Linda B. Selenica, Daniel C. Lee, Dieu-Trang Fuchs, Maya Koronyo-Hamaoui
Xenografted human iPSC-derived neurons with the familial Alzheimer’s disease APPV717I mutation reveal dysregulated transcriptome signatures linked to synaptic function and implicate LINGO2 as a disease signaling mediator
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-25
Wenhui Qu, Matti Lam, Julie J. McInvale, Jason A. Mares, Sam Kwon, Nelson Humala, Aayushi Mahajan, Trang Nguyen, Kelly A. Jakubiak, Jeong-Yeon Mun, Thomas G. Tedesco, Osama Al-Dalahmah, Syed A. Hussaini, Andrew A. Sproul, Markus D. Siegelin, Philip L. De Jager, Peter Canoll, Vilas Menon, Gunnar Hargus
Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-22
Fari Ryan, Christian Blex, The Dung Ngo, Marcel A. Kopp, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Jan M. Schwab, Klemens Ruprecht, Carolin Otto, Priya Jhelum, Antje Kroner, Samuel David
Inter-alpha-trypsin inhibitor heavy chain H3 is a potential biomarker for disease activity in myasthenia gravis
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-18
Christina B. Schroeter, Christopher Nelke, Frauke Stascheit, Niklas Huntemann, Corinna Preusse, Vera Dobelmann, Lukas Theissen, Marc Pawlitzki, Saskia Räuber, Alice Willison, Anna Vogelsang, Adela Della Marina, Hans-Peter Hartung, Nico Melzer, Felix F. Konen, Thomas Skripuletz, Andreas Hentschel, Simone König, Michaela Schweizer, Kai Stühler, Gereon Poschmann, Andreas Roos, Werner Stenzel, Andreas
Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-17
Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman, Moses J. Leavens
Correction to: Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-13
Yingli Zhu, Thibaut Burg, Katrien Neyrinck, Tim Vervliet, Fatemeharefeh Nami, Ellen Vervoort, Karan Ahuja, Maria Livia Sassano, Yoke Chin Chai, Arun Kumar Tharkeshwar, Jonathan De Smedt, Haibo Hu, Geert Bultynck, Patrizia Agostinis, Johannes V. Swinnen, Ludo Van Den Bosch, Rodrigo Furtado Madeiro da Costa, Catherine Verfaillie
Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer’s disease
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-10
Feng Gao, Mengguo Zhang, Qiong Wang, Ming Ni, Chang Liu, Kexue Deng, Qiang Xie, Shicung Wang, Jiong Shi, Yong Shen
Clinically unfavorable transcriptome subtypes of non-WNT/non-SHH medulloblastomas are associated with a predominance in proliferating and progenitor-like cell subpopulations
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-07
Konstantin Okonechnikov, Daniel Schrimpf, Jan Koster, Philipp Sievers, Till Milde, Felix Sahm, David T. W. Jones, Andreas von Deimling, Stefan M. Pfister, Marcel Kool, Andrey Korshunov
Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer’s disease pathology progression
Acta Neuropathol.
(IF 9.3 )
Pub Date : 2024-06-04
Kunie Ando, Fahri Küçükali, Emilie Doeraene, Siranjeevi Nagaraj, Eugenia Maria Antonelli, May Thazin Htut, Zehra Yilmaz, Andreea-Claudia Kosa, Lidia Lopez-Guitierrez, Carolina Quintanilla-Sánchez, Emmanuel Aydin, Ana Raquel Ramos, Salwa Mansour, Sabrina Turbant, Stéphane Schurmans, Kristel Sleegers, Christophe Erneux, Jean-Pierre Brion, Karelle Leroy
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