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EAU à la mode Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-17 Louise Lloyd
Urologists from around the world congregated at the 39th Annual Congress of the European Association of Urology (EAU), which took place in Paris, France, between 5 and 8 April 2024. In the Olympic host city, the Olympian efforts of clinicians and researchers in the field to improve knowledge and understanding and, ultimately, patient outcomes were evident around the convention centre. Day 1 of the
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The evolving landscape of monogenic nephrolithiasis and therapeutic innovations Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-17 Chen-Han Wilfred Wu, Yu-Ren Huang, Donald Bodner, Fredrick R. Schumacher, Michelle Baum, Friedhelm Hildebrandt
Monogenic causes account for up to 20% of nephrolithiasis instances and are crucial for developing targeted treatments. Whole-exome sequencing, genome-wide association, candidate gene, and in vitro and animal functional studies are crucial to identify these mutations. Therapies targeting monogenic variants, such as RNA-interference-based treatments, have been successfully used to treat monogenic disorders
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Patient-reported toxic effects of hypofractionated versus conventional RT Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-16 Maria Chiara Masone
Post-prostatectomy radiotherapy (RT) is a common second-line treatment for patients with prostate cancer. In the phase III randomized NRG-GU003 trial, hypofractionated postprostatectomy RT (HYPORT) was compared with conventionally fractionated postprostatectomy RT (COPORT) in terms of patient-reported genitourinary (GU) and gastrointestinal (GI) symptoms in patients with prostate cancer who had received
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Safe delivery of ICI therapy through sub-urothelial injection Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-16 Maria Chiara Masone
Systemic treatment with the human monoclonal anti-PDL1 antibody durvalumab showed benefit in several cancers. In a phase Ib study published in BJU International, the safety of sub-urothelial durvalumab injection was assessed in patients with non-metastatic muscle-invasive or non-muscle-invasive bladder cancer planned to receive radical cystectomy. Overall, 11 patients received sub-urothelial injection
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HRQoL in patients receiving EV versus chemotherapy Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-16 Maria Chiara Masone
In the phase III EV-301 trial, enfortumab vedotin (EV) has been shown to increase overall survival compared with chemotherapy in patients with metastatic urothelial carcinoma who had previously received chemotherapy and experienced disease progression after treatment with PD1 or PDL1 inhibitors. In a study published in European Urology, patient-reported outcome (PRO) analysis of health-related quality
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Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-16 Pham Hong Anh Cao, Abishai Dominic, Fabiola Ester Lujan, Sanjanaa Senthilkumar, Pratip K. Bhattacharya, Daniel E. Frigo, Elavarasan Subramani
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A CAF subpopulation promotes LVI in early-stage bladder cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-15 Maria Chiara Masone
In a new article published in Cancer Cell, a subset of cancer-associated fibroblasts (CAFs) was shown to have a crucial role in promoting lymphovascular invasion (LVI) in early-stage bladder cancer. In this study, LVI analysis in tissue samples from patients with bladder cancer showed that LVI in patients with early-stage disease was associated with increased rates of lymph node (LN) metastases and
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The case for centralization of care in penile cancer — respecting geographical needs Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-04-15 Giuseppe Basile, Andrea Necchi, Gagan Prakash, Karima Oualla, Philippe E. Spiess, Peter A. S. Johnstone
Centralization of care for penile cancer has been underscored in the 2023 updated EAU–ASCO guidelines. Expertise consolidation enhances patient care, addressing penile cancer complexities from diagnosis to treatment. Centralization initiatives, like the European Reference Networks, and dedicated scientific societies have crucial roles in guiding centralized care pathways to ultimately improve patient
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Signatures of metabolic diseases on spermatogenesis and testicular metabolism Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-03-25 David F. Carrageta, Sara C. Pereira, Rita Ferreira, Mariana P. Monteiro, Pedro F. Oliveira, Marco G. Alves
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Robots learning to imitate surgeons — challenges and possibilities Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-03-21 Samuel Schmidgall, Ji Woong Kim, Axel Krieger
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Overcoming antibiotic resistance in complicated UTI Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-03-14 Maria Chiara Masone
Complicated urinary tract infection (UTI) is a debilitating condition often resulting in patient hospitalization and consequent high health-care costs. β-lactam antibiotics such as cephalosporins are often used to treat complicated UTI, but a widespread resistance to antibiotics hampers the eradication of these infections. The phase III, randomized, double-blind, double-dummy trial CERTAIN-1 was conducted
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The ins and outs of penile erection Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-03-14 Louise Lloyd
New discoveries concerning the function of fibroblasts in penile erection have improved our understanding of this physiological process. In humans, fibroblasts are the largest cell population in the corpora cavernosa, but until now their function had not been elucidated. “We study perivascular fibroblasts in the context of fibrosis in the central nervous system and I was curious about their physiological
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Robotic kidney transplantation Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-03-13 Giuseppe Basile, Alessio Pecoraro, Andrea Gallioli, Angelo Territo, Camille Berquin, Jorge Robalino, Alejandra Bravo, Jorge Huguet, Óscar Rodriguez-Faba, Pavel Gavrilov, Carmen Facundo, Lluis Guirado, Josep Maria Gaya, Joan Palou, Alberto Breda
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Diversifying editorial boards to mitigate the global burden of genitourinary cancers Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-03-01 David J. Benjamin, Zhaohui Arter, Nataliya Mar, Arash Rezazadeh Kalebasty
The growing global burden of genitourinary cancers is disproportionately shouldered by low- and middle-income countries. Medical journals offer an avenue for discourse among different stakeholders to strategize and identify solutions. Thus, achieving diversity in this context is crucial to put together a heterogeneous group of stakeholders with diverse personal and cultural experiences as well as distinct
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Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-19 Shiyu Zhang, Tianhai Lin, Xingyu Xiong, Chong Chen, Ping Tan, Qiang Wei
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The evolving management of small renal masses Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-16 Yuzhi Wang, Mohit Butaney, Samantha Wilder, Khurshid Ghani, Craig G. Rogers, Brian R. Lane
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Sun, sea, sex and spaghetti as the ESSM hits Bari Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-16 Annette Fenner
Delegates were treated to a fantastic menu of both science and gastronomy as the European Society for Sexual Medicine (ESSM) Congress met in Bari, southern Italy, 9–11 February 2024. Unsurprisingly, Italy topped the list of attendees at this cosmopolitan meeting, which saw 650 delegates converge from across the world to discuss the latest research and topics in sexual medicine. A total of 72 scientific
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ADT intensification to treat biochemically recurrent prostate cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-14 Maria Chiara Masone
In the randomized phase III, open-label trial PRESTO, the effect of potentiating androgen deprivation therapy (ADT) on improving oncological outcomes in patients with biochemically recurrent prostate cancer (BRPC) was assessed. Patients with BRPC (n = 503) and a short PSA doubling time (≤9 months) were enrolled and randomized 1:1:1 to receive ADT (control arm), ADT + apalutamide, or ADT + apalutamide + abiraterone
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A new rapid point-of-care test for N. gonorrhoeae Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-14 Maria Chiara Masone
The lack of a rapid, cheap point-of-care test to diagnose infection with Neisseria gonorrhoeae has led to overuse of antibiotics and syndromic treatment. In a study published in The Lancet, the diagnostic performance of a new N. gonorrhoeae lateral flow assay (NG-LFA), which had shown promising results in frozen clinical specimens, was assessed in male patients with urethral discharges (n = 200) and
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Mellow yellow: BilR reduces bilirubin to urobilinogen Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-14 Louise Lloyd
Researchers have identified the enzyme, now called bilirubin reductase (BilR), that converts bilirubin to urobilinogen, giving urine its distinctive yellow colour. The reduction of bilirubin to urobilinogen is performed solely by the gut microbiota; however, hitherto the gut microbial enzyme that reduces bilirubin to urobilinogen had not been discovered. Using a fluorescence assay on various bacteria
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First-morning urine samples to study the urobiome Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-14 Maria Chiara Masone
The urinary microbiome (urobiome) is emerging as a new contributing factor in determining bladder cancer risk, but data from different studies are conflicting, owing to the lack of standardization. In a new study published in European Urology Open Science, a urobiome analysis was conducted in 48 patients undergoing transurethral resection of bladder tumour, through the next-generation sequencing analysis
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RNA N6-methyladenosine modifications in urological cancers: from mechanism to application Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-12 Lei Yang, Jianming Ying, Qian Tao, Qian Zhang
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Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-07 Ashu Mohammad, Mallory A. Laboulaye, Chen Shenhar, Amy D. Dobberfuhl
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Molecular profile of bladder cancer progression to clinically aggressive subtypes Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-06 Charles C. Guo, Sangkyou Lee, June G. Lee, Huiqin Chen, Michael Zaleski, Woonyoung Choi, David J. McConkey, Peng Wei, Bogdan Czerniak
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Supplementary selenium and vitamin E in non-muscle-invasive bladder cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-05 Shaun J. Trecarten, Robert S. Svatek
In the SELENIB trial, selenium and vitamin E were compared with placebo as chemoprevention for non-muscle-invasive bladder cancer (NMIBC). No difference versus placebo was observed in recurrence-free interval (RFI) with selenium, but vitamin E was associated with worse RFI. Selenium and vitamin E cannot be recommended in chemoprevention for NMIBC. Furthermore, patients with NMIBC taking supplemental
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The complex interplay of modifiable risk factors affecting prostate cancer disparities in African American men Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-02 Jabril R. Johnson, Nicole Mavingire, Leanne Woods-Burnham, Mya Walker, Deyana Lewis, Stanley E. Hooker, Dorothy Galloway, Brian Rivers, Rick A. Kittles
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The yin and yang of chromosomal instability in prostate cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-02-02 Marc Carceles-Cordon, Jacob J. Orme, Josep Domingo-Domenech, Veronica Rodriguez-Bravo
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Management of patients with muscle-invasive bladder cancer with clinical evidence of pelvic lymph node metastases Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-31 Elisabeth Grobet-Jeandin, Louis Lenfant, Ugo Pinar, Jérôme Parra, Pierre Mozer, Raphaele Renard-Penna, Constance Thibault, Morgan Rouprêt, Thomas Seisen
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Pembrolizumab plus enfortumab vedotin in urothelial cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-24 Matteo Santoni, Hideki Takeshita, Francesco Massari, Aristotelis Bamias, Linda Cerbone, Ondrej Fiala, Veronica Mollica, Sebastiano Buti, Angela Santoni, Joaquim Bellmunt
The combination of pembrolizumab and enfortumab vedotin shows promise as a first-line therapy for advanced urothelial carcinoma. Enfortumab vedotin targets nectin-4, in turn enhancing T cell and natural killer cell activity, inhibiting immunosuppressive pathways and impeding tumour evasion. This synergy with pembrolizumab shows potential in enhancing immunotherapy for these patients.
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Sperm activity affected by endometriosis Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-22 Annette Fenner
Endometriosis-associated infertility is regulated via extracellular vesicles, with a direct effect on sperm activity, according to data published in the Journal of Cellular Physiology.
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A clinical overview of people living with HIV and genitourinary cancer care Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-18 Chalairat Suk-Ouichai, Anna E. Coghill, Matthew B. Schabath, Julian A. Sanchez, Jad Chahoud, Andrea Necchi, Anna R. Giuliano, Philippe E. Spiess
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Gut microbiome’s effect on immunotherapy response Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-16 Maria Chiara Masone
The gut microbiome has been shown to have a role in mediating the anticancer activity of immune checkpoint inhibitors. In a new study published in European Urology, the composition and role of the stool microbiome was assessed in patients with muscle-invasive bladder cancer who received pembrolizumab in the PURE-01 trial. Different microbial species were enriched in respondents versus non-respondents
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Urinoids — a new tool to study bladder cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-16 Maria Chiara Masone
Current treatments for bladder cancer are only effective in a limited percentage of patients, indicating that personalized treatment based on individual tumour characteristics is needed. In a new study published in the British Journal of Cancer, bladder cancer organoids were established non-invasively from patients’ urine (urinoids). These urinoids recapitulated the histological features and the genetic
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Effect of bariatric surgery on sexual function Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-16 Maria Chiara Masone
Men with obesity can experience several medical and psychological issues, including sexual dysfunction and a reduction of testosterone levels. Bariatric surgery has been proposed to ameliorate sexual function in these men, but data are scarce. In a prospective study, hormonal levels, semen parameters and sexual libido were assessed in 20 men before and 6 months after bariatric surgery. No differences
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Focusing on male infertility Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-16
The burden of male infertility is often unrecognized and its causes are poorly understood. Efforts to increase awareness and understanding are being undertaken to improve fertility outcomes and overall health for affected men.
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Being a non-native English speaker in science and medicine Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-15 Sigrid V. Carlsson, Sandro C. Esteves, Elisabeth Grobet-Jeandin, Maria Chiara Masone, Maria J. Ribal, Yao Zhu
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The effect of red blood cell disorders on male fertility and reproductive health Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-03 Bryan D. Naelitz, Prajit S. Khooblall, Neel V. Parekh, Sarah C. Vij, Seth J. Rotz, Scott D. Lundy
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Shared decision-making before prostate cancer screening decisions Nat. Rev. Urol. (IF 15.3) Pub Date : 2024-01-02 Kelly R. Pekala, Daniela K. Shill, Mia Austria, Aisha T. Langford, Stacy Loeb, Sigrid V. Carlsson
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Intratumoural immunotherapy plus focal thermal ablation for localized prostate cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-12-19 Denis Séguier, Eric S. Adams, Srinath Kotamarti, Vincent D’Anniballe, Zoe D. Michael, Sriram Deivasigamani, Jonathan Olivier, Arnauld Villers, Christopher Hoimes, Thomas J. Polascik
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Molecular mechanisms of cellular dysfunction in testes from men with non-obstructive azoospermia Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-12-18 Arina Piechka, Sydney Sparanese, Luke Witherspoon, Faraz Hach, Ryan Flannigan
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Mechanical characteristics of the ureter and clinical implications Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-12-15 Sorcha O’Meara, Eoghan M. Cunnane, Stefanie M. Croghan, Connor V. Cunnane, Michael T. Walsh, Fergal J. O’Brien, Niall F. Davis
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AUC 23 — top-notch urology in a tropical paradise Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-12-14 Maria Chiara Masone
The outstanding all-inclusive resort Club Med Michès Playa Esmeralda in the Dominican Republic hosted the 2nd edition of the Advances in Urologic Care (AUC) meeting, from 13 to 16 November 2023. After a spectacular first meeting in Bora Bora in 2019, this was the first edition after the lifting of COVID-19 restrictions.
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Human-relevant urothelial model provides insight into infection strategies and host response Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-12-07 Louise Lloyd
Use of a 3D urine-tolerant human urothelial model (3D-UHU), which recapitulates the crucial features of human urothelium, has enabled characterization and improved understanding of colonization and survival strategies used by uropathogens and commensal bacteria. The results of this study provide insights into strain-specific and species-specific infection strategies and the reciprocal host responses
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Management and cost of stent encrustation in pregnancy Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-12-04 Francesco Di Bello, Gianluigi Califano, Claudia Collà Ruvolo, Simone Morra, Roberto La Rocca, Massimiliano Creta, Luigi Napolitano, Nicola Longo, Giuseppe Celentano
Ureteral stents are useful devices for urological management in pregnancy. However, stent encrustation occurs in up to 13% of patients and is related to increased indwelling time. Stent encrustation can be harmful for both the mother and the fetus, increasing their morbidity and mortality. Thus, whether prevention or cure is more cost effective is pertinent.
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Clinical application of bladder MRI and the Vesical Imaging-Reporting And Data System Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-11-30 Valeria Panebianco, Alberto Briganti, Thierry N. Boellaard, James Catto, Eva Comperat, Jason Efstathiou, Antoine G. van der Heijden, Gianluca Giannarini, Rossano Girometti, Laura Mertens, Mitsuru Takeuchi, Valdair F. Muglia, Yoshifumi Narumi, Giacomo Novara, Martina Pecoraro, Morgan Roupret, Francesco Sanguedolce, Daniele Santini, Shahrokh F. Shariat, Giuseppe Simone, Hebert A. Vargas, Sungmin Woo
Diagnostic work-up and risk stratification in patients with bladder cancer before and after treatment must be refined to optimize management and improve outcomes. MRI has been suggested as a non-invasive technique for bladder cancer staging and assessment of response to systemic therapy. The Vesical Imaging-Reporting And Data System (VI-RADS) was developed to standardize bladder MRI image acquisition
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Generative AI in scientific publishing: disruptive or destructive? Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-11-15 Riccardo Bertolo, Alessandro Antonelli
Artificial intelligence (AI) has the potential to revolutionize scientific publishing. The influence of AI could be disruptive or destructive and its influence remains to be seen, but balance between the convenience and accessibility offered by AI-driven tools and the essential skills of deep scientific inquiry and communication needs to be found.
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Idea sprint: generating research priorities for urinary stone disease Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-11-15 Golena Fernandez Moncaleano, William W. Roberts, John D. Denstedt, Khurshid R. Ghani
The escalating global prevalence of urinary stone disease and its impact on public health reflects the need to synthesize ideas that can help with the development of critical research priorities. By bringing together a forum of endourologists with the support of a funding agency, the IDEA session aimed to identify important future research topics.
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Genetic and biological drivers of prostate cancer disparities in Black men Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-11-14 Jun Gong, Daniel M. Kim, Michael R. Freeman, Hyung Kim, Leigh Ellis, Bethany Smith, Dan Theodorescu, Edwin Posadas, Robert Figlin, Neil Bhowmick, Stephen J. Freedland
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Resolving the puzzle of same-sex sexual interactions Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-11-08 C. Ruth Archer, David J. Hosken
Sexual interactions between members of the same sex are common but the reasons for these behaviours are not always clear. Results from a study across mammals suggest that increased same-sex behaviour evolved with sociality and might reduce conflict, although increased male–male sexual interactions are associated with increased adult killing.
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Bladder-sparing neoadjuvant therapy for MIBC Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-11-01 Louise Stone
Patients with muscle-invasive bladder cancer (MIBC) could avoid undergoing radical cystectomy (the current standard-of-care treatment) and its associated morbidity if they achieve a clinical complete response (cCR) on neoadjuvant combination treatment consisting of four cycles of gemcitabine, cisplatin and nivolumab.
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Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-10-31 Joakin O. Mori, Isra Elhussin, W. Nathaniel Brennen, Mindy K. Graham, Tamara L. Lotan, Clayton C. Yates, Angelo M. De Marzo, Samuel R. Denmeade, Srinivasan Yegnasubramanian, William G. Nelson, Gerald V. Denis, Elizabeth A. Platz, Alan K. Meeker, Christopher M. Heaphy
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Hallmark discoveries in the biology of Wilms tumour Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-10-17 Daniela Perotti, Richard D. Williams, Jenny Wegert, Jack Brzezinski, Mariana Maschietto, Sara Ciceri, David Gisselsson, Samantha Gadd, Amy L. Walz, Rhoikos Furtwaengler, Jarno Drost, Reem Al-Saadi, Nicholas Evageliou, Saskia L. Gooskens, Andrew L. Hong, Andrew J. Murphy, Michael V. Ortiz, Maureen J. O’Sullivan, Elizabeth A. Mullen, Marry M. van den Heuvel-Eibrink, Conrad V. Fernandez, Norbert Graf
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Family dynamics: fathers’ smoking affects children’s epigenetics Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-10-13 Louise Stone
New research has shown that fathers’ preconception smoking behaviour can affect DNA methylation in their children. This observation has implications for offspring and public health.
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Frequency, morbidity and equity — the case for increased research on male fertility Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-10-12 Sarah Kimmins, Richard A. Anderson, Christopher L. R. Barratt, Hermann M. Behre, Sarah R. Catford, Christopher J. De Jonge, Geraldine Delbes, Michael L. Eisenberg, Nicolas Garrido, Brendan J. Houston, Niels Jørgensen, Csilla Krausz, Ariane Lismer, Robert I. McLachlan, Suks Minhas, Tim Moss, Allan Pacey, Lærke Priskorn, Stefan Schlatt, Jacquetta Trasler, Leonardo Trasande, Frank Tüttelmann, Mónica Hebe
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Unlocking the mystery of the human Y chromosome Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-10-06 Miguel G. Rojas, Edoardo Pozzi, Ranjith Ramasamy
Much of the Y chromosome has remained obscure owing to the challenge of sequencing repetitive genomic regions. Recently, the Y chromosome has been fully sequenced, revealing extensive heterochromatic areas and 41 new protein-coding genes. Furthermore, 43 Y chromosomes have been sequenced, showing extensive multi-sample variation and providing promising insights into male infertility.
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Kidney xenotransplantation Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-10-04 Louise Stone
The successful transplantation of a transgenic kidney from a pig to a human has been described by two surgical teams. Xenotransplantation, if successful in the long term, is one possible solution to the scarcity of kidneys for people who require a transplant.
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Diagnostic liquid biopsy biomarkers in renal cell cancer Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-09-27 Richard C. Zieren, Patricia J. Zondervan, Kenneth J. Pienta, Axel Bex, Theo M. de Reijke, Adriaan D. Bins
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Improved phenotypic classification of male infertility to promote discovery of genetic causes Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-09-18 Margot J. Wyrwoll, Godfried W. van der Heijden, Csilla Krausz, Kenneth I. Aston, Sabine Kliesch, Robert McLachlan, Liliana Ramos, Donald F. Conrad, Moira K. O’Bryan, Joris A. Veltman, Frank Tüttelmann
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Feasibility and potential of an MRI-based prostate cancer screening Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-09-11 Maria Chiara Masone
Prostate cancer screening using prostate-specific antigen (PSA) followed by biopsy has been shown to reduce mortality but results in overdiagnosis and overtreatment in a substantial percentage of patients.
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Accessing information in the AI age Nat. Rev. Urol. (IF 15.3) Pub Date : 2023-09-11 Louise Stone
Online sources are increasingly being used by patients to obtain medical information. The newest of these resources, artificial intelligence (AI) chatbots, are becoming ever more popular tools with the public and could be accurate sources of information. Another accessible and approachable format is the podcast. However, the veracity and utility of these sources of information need investigation.