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Elevated nutrient availability enhances chondrocyte metabolism and biosynthesis in tissue-engineered cartilage Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-12 Roberto Tarantino, Halie Mei Jensen, Stephen D. Waldman
Chondrocytes, which typically rely on anaerobic metabolism, exhibit upregulated biosynthetic activity when subjected to conditions that elicit mixed aerobic-anaerobic metabolism. Previously, we observed that increasing media volume resulted in the transition from anaerobic to mixed aerobic-anaerobic metabolism. Maximal extracellular matrix (ECM) accumulation occurred at this transition as a result
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Sorafenib inhibits ossification of the posterior longitudinal ligament by blocking LOXL2-mediated vascularization Bone Res. (IF 12.7) Pub Date : 2024-04-10 Longqing Wang, Wenhao Jiang, Siyuan Zhao, Dong Xie, Qing Chen, Qi Zhao, Hao Wu, Jian Luo, Lili Yang
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Cell membrane vesicles derived from hBMSCs and hUVECs enhance bone regeneration Bone Res. (IF 12.7) Pub Date : 2024-04-09 Dandan Wang, Yaru Guo, Boon Chin Heng, Xuehui Zhang, Yan Wei, Ying He, Mingming Xu, Bin Xia, Xuliang Deng
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Transient receptor potential vanilloid 4 regulates extracellular matrix composition and mediates load-induced intervertebral disc degeneration in a mouse model Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-09 Min Kyu, Mark Kim, Matthew Lawrence, Diana Quinonez, Courtney Brooks, Rithwik Ramachandran, Cheryle A. Séguin
Transient receptor potential vanilloid 4 (TRPV4) is a multi-modally activated cation channel that mediates mechanotransduction pathways by which musculoskeletal tissues respond to mechanical load and regulate tissue health. Using conditional knockout mice, we investigated the role of in regulating intervertebral disc (IVD) health and injury-induced IVD degeneration. ( KO) mice were used to knockout
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Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Neil A. Segal, Jeannine M. Nilges, Win Min Oo
Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses than men. However, the underlying factors and therapeutic outcomes of these sex-specific differences are incompletely researched. This review examines the current state of knowledge regarding sex differences in OA prevalence, risk factors, pain severity, functional outcomes, and use and response to therapeutics. PubMed
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Pioneering a chick embryo model to explore the intrauterine etiology of developmental dysplasia of the hip in oligohydramnios conditions Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-06 Shaoting Luo, Yufan Chen, Weizheng Zhou, Federico Canavese, Lianyong Li
To explore the impact of oligohydramnios on fetal movement and hip development, given its association with developmental dysplasia of the hip (DDH) but unclear mechanisms. Chick embryos were divided into four groups based on the severity of oligohydramnios induced by amniotic fluid aspiration (control, 0.2 mL, 0.4 mL, 0.6 mL). Fetal movement was assessed by detection of movement and quantification
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How Did Black and Hispanic Orthopaedic Applicants and Residents Compare to General Surgery Between 2015 and 2022? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-04 Alisha J Williams, Julia I Malewicz, John M Pum, David Zurakowski, Charles S Day
Despite the heavy demand for and knowledge of the benefits of diversity, there is a persistent lack of racial, ethnic, and gender diversity in orthopaedic surgery. Since the implementation of diversity initiatives, data have shown that general surgery has been one of the top competitive surgical fields and has demonstrated growth in racial, ethnic, and gender diversity, making general surgery a good
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High Area Deprivation Index is Associated With Not Achieving the Patient-acceptable Symptom State After TKA. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-04-03 Matthew J Hadad, Ignacio Pasqualini, Alison K Klika, Yuxuan Jin, Matthew E Deren, Viktor E Krebs, Trevor G Murray, Nicolas S Piuzzi
The Area Deprivation Index (ADI) approximates a patient's relative socioeconomic deprivation. The ADI has been associated with increased healthcare use after TKA, but it is unknown whether there is an association with patient-reported outcome measures (PROMs). Given that a high proportion of patients are dissatisfied with their results after TKA, and the large number of these procedures performed,
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Exploring the association of gender role expectations of pain and measures of pain sensitization in people with knee osteoarthritis: A cross-sectional study Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Y.V. Raghava Neelapala, Saurab Sharma, Lisa C. Carlesso
First, we explored the association between Gender Role Expectations of Pain (GREP), and psychophysical measures of sensitization in people with knee osteoarthritis (OA). Second, we explored whether the association differed by level of GREP items (high vs low scores). We conducted secondary analyses of a cohort study. Those who were (i) age of ≥40, English or French speaking, ii) diagnosed with knee
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Post-traumatic and OA-related lesions in the knee at baseline and 2 years after traumatic meniscal injury: Secondary analysis of a randomized controlled trial Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-04-02 Sabine J.A. van der Graaff, Edwin H.G. Oei, Max Reijman, Lars Steenbekkers, Marienke van Middelkoop, Rianne A. van der Heijden, Duncan E. Meuffels, STARR Study Group
To assess the presence of early degenerative changes on Magnetic Resonance Imaging (MRI) 24 months after a traumatic meniscal tear and to compare these changes in patients treated with arthroscopic partial meniscectomy or physical therapy plus optional delayed arthroscopic partial meniscectomy. We included patients aged 18–45 years with a recent onset, traumatic, MRI verified, isolated meniscal tear
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The pathogenic mechanism of syndactyly type V identified in a Hoxd13Q50R knock-in mice Bone Res. (IF 12.7) Pub Date : 2024-04-01 Han Wang, Xiumin Chen, Xiaolu Meng, Yixuan Cao, Shirui Han, Keqiang Liu, Ximeng Zhao, Xiuli Zhao, Xue Zhang
Syndactyly type V (SDTY5) is an autosomal dominant extremity malformation characterized by fusion of the fourth and fifth metacarpals. In the previous publication, we first identified a heterozygous missense mutation Q50R in homeobox domain (HD) of HOXD13 in a large Chinese family with SDTY5. In order to substantiate the pathogenicity of the variant and elucidate the underlying pathogenic mechanism
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Skeletal interoception in osteoarthritis Bone Res. (IF 12.7) Pub Date : 2024-04-01 Dinglong Yang, Jiawen Xu, Ke Xu, Peng Xu
The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the organism. Among its various forms, skeletal interoception specifically regulates the metabolic homeostasis of bones. Osteoarthritis (OA) is a complex joint disorder involving cartilage, subchondral bone, and synovium. The subchondral
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Development and validation of a trauma frailty scale in severely injured patients: the Nottingham Trauma Frailty Index. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Abdullah G Alqarni, Jessica Nightingale, Alan Norrish, John R F Gladman, Benjamin Ollivere
Frailty greatly increases the risk of adverse outcome of trauma in older people. Frailty detection tools appear to be unsuitable for use in traumatically injured older patients. We therefore aimed to develop a method for detecting frailty in older people sustaining trauma using routinely collected clinical data.
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The rate of nonunion in the MRI-detected occult scaphoid fracture. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Benjamin J F Dean, Nicholas Riley, Christopher Little, Warren Sheehan, Sam Gidwani, Mark Brewster, Paula Dhiman, Matt L Costa
There is a lack of published evidence relating to the rate of nonunion seen in occult scaphoid fractures, diagnosed only after MRI. This study reports the rate of delayed union and nonunion in a cohort of patients with MRI-detected acute scaphoid fractures.
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Prognostic factors for clinical outcomes after arthroscopic treatment of traumatic central tears of the triangular fibrocartilage complex. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Jae-Yong Cho, Sung-Woo Lee, Do-Hyun Kim, Won-Taek Oh, Il-Hyun Koh, Yong-Min Chun, Yun-Rak Choi
The study aimed to assess the clinical outcomes of arthroscopic debridement and partial excision in patients with traumatic central tears of the triangular fibrocartilage complex (TFCC), and to identify prognostic factors associated with unfavourable clinical outcomes.
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Unveiling the learning curve of periacetabular osteotomy. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Marco Haertlé, Nils Becker, Henning Windhagen, Sufian S Ahmad
Periacetabular osteotomy (PAO) is widely recognized as a demanding surgical procedure for acetabular reorientation. Reports about the learning curve have primarily focused on complication rates during the initial learning phase. Therefore, our aim was to assess the PAO learning curve from an analytical perspective by determining the number of PAOs required for the duration of surgery to plateau and
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Two-stage revision for periprosthetic joint infection after hip and knee arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Jennifer Straub, Kevin Staats, Klemens Vertesich, Lars Kowalscheck, Reinhard Windhager, Christoph Böhler
Histology is widely used for diagnosis of persistent infection during reimplantation in two-stage revision hip and knee arthroplasty, although data on its utility remain scarce. Therefore, this study aims to assess the predictive value of permanent sections at reimplantation in relation to reinfection risk, and to compare results of permanent and frozen sections.
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Acetabular Fractures in older patients Intervention Trial (AceFIT): a feasibility triple-arm randomized controlled study. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Andrew Carrothers, Ronan O'Leary, Peter Hull, Daud Chou, Joseph Alsousou, Joseph Queally, Simon J Bond, Matthew L Costa
To assess the feasibility of a randomized controlled trial (RCT) that compares three treatments for acetabular fractures in older patients: surgical fixation, surgical fixation and hip arthroplasty (fix-and-replace), and non-surgical treatment.
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Cemented dual-mobility constructs in uncemented revision acetabular components. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Jacob M Wilson, Robert T Trousdale, Nicholas A Bedard, David G Lewallen, Daniel J Berry, Matthew P Abdel
Dislocation remains a leading cause of failure following revision total hip arthroplasty (THA). While dual-mobility (DM) bearings have been shown to mitigate this risk, options are limited when retaining or implanting an uncemented shell without modular DM options. In these circumstances, a monoblock DM cup, designed for cementing, can be cemented into an uncemented acetabular shell. The goal of this
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A prospective randomized controlled trial comparing CT-based planning with conventional total hip arthroplasty versus robotic arm-assisted total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Andreas Fontalis, Babar Kayani, Ricci Plastow, Dia E Giebaly, Jenni Tahmassebi, Isabella C Haddad, Alastair Chambers, Fabio Mancino, Sujith Konan, Fares S Haddad
Achieving accurate implant positioning and restoring native hip biomechanics are key surgeon-controlled technical objectives in total hip arthroplasty (THA). The primary objective of this study was to compare the reproducibility of the planned preoperative centre of hip rotation (COR) in patients undergoing robotic arm-assisted THA versus conventional THA.
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Do breast cancer patients have increased risk of complications after primary total hip and total knee arthroplasty? Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Cameron K Ledford, Matthew B Shirley, Mark J Spangehl, Daniel J Berry, Matthew P Abdel
Breast cancer survivors have known risk factors that might influence the results of total hip arthroplasty (THA) or total knee arthroplasty (TKA). This study evaluated clinical outcomes of patients with breast cancer history after primary THA and TKA.
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Revision total hip arthroplasty using a modular fluted, tapered revision femoral component and interlocking screws in Vancouver B3 periprosthetic fractures with insufficient bone at the isthmus. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Bernd Fink, Arman Ahmadian, Florian H Sax, Philipp Schuster
Revision total hip arthroplasty in patients with Vancouver type B3 fractures with Paprosky type IIIA, IIIB, and IV femoral defects are difficult to treat. One option for Paprovsky type IIIB and IV defects involves modular cementless, tapered, revision femoral components in conjunction with distal interlocking screws. The aim of this study was to analyze the rate of reoperations and complications and
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Bone support of a custom triflange acetabular component over time. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Erim Özdemir, Bram de Lange, Constantinus F M Buckens, Wim H C Rijnen, Jetze Visser
To investigate the extent of bone development around the scaffold of custom triflange acetabular components (CTACs) over time.
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How modular porous metal augments have changed the management of acetabular bone loss at primary or revision total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Neil P Sheth, Stephen A Jones, Sahil A Sanghavi, Andrew Manktelow
The advent of modular porous metal augments has ushered in a new form of treatment for acetabular bone loss. The function of an augment can be seen as reducing the size of a defect or reconstituting the anterosuperior/posteroinferior columns and/or allowing supplementary fixation. Depending on the function of the augment, the surgeon can decide on the sequence of introduction of the hemispherical shell
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Patient-reported outcome measures in hip fracture patients. Bone Joint J. (IF 4.6) Pub Date : 2024-04-01 Cato Kjærvik, Jan-Erik Gjertsen, Eva Stensland, Eva H Dybvik, Odd Soereide
The aims of this study were to assess quality of life after hip fractures, to characterize respondents to patient-reported outcome measures (PROMs), and to describe the recovery trajectory of hip fracture patients.
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Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx Bone Res. (IF 12.7) Pub Date : 2024-03-29 Ziqian Xiang, Pengfei Zhang, Chunwang Jia, Rongkun Xu, Dingren Cao, Zhaoning Xu, Tingting Lu, Jingwei Liu, Xiaoxiong Wang, Cheng Qiu, Wenyang Fu, Weiwei Li, Lei Cheng, Qiang Yang, Shiqing Feng, Lianlei Wang, Yunpeng Zhao, Xinyu Liu
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Studies on postoperative outcome prognostic factors reveal intrinsic nature of osteoarthritis as a systemic disease: Comment on Osteoarthritis and Cartilage 2023;24(1):98–107 Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-29 E.V. Tchetina, E.A. Taskina
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What is the Long-term Wear of a 5-Mrad Highly Crosslinked Polyethylene Liner? A 14-year RSA Study. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-28 Stuart A Callary, Deepti K Sharma, Taisha M D'Apollonio, Owain Critchley, Graham Mercer, Christopher Wilson, David G Campbell
Lower doses of irradiation (≤ 5 Mrad) during the manufacture of highly crosslinked polyethylene acetabular liners may result in less crosslinking and an increased wear rate. Radiostereometric analysis (RSA) studies have found that wear of more highly irradiated highly crosslinked polyethylene liners (7 to 10 Mrad) decreases at longer-term follow-up compared with earlier reports of the same cohorts
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One leg testing in hip and knee osteoarthritis: A comparison with a two-leg oriented functional outcome measure and self-reported functional measures Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-27 R. Bendrik, B. Sundström, K. Bröms, M. Emtner, LV Kallings, M. Peterson
To compare the responsiveness of two unilateral lower-limb performance-based tests, the one-leg rise test and the maximal step-up test, with the bilateral 30-second chair-stand test and the self-reported measure of physical function (HOOS/KOOS). Specific aims were to evaluate responsiveness, floor/ceiling effect and association between the instruments. Data was included from 111 participants, mean
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Sex-specific effects of injury and beta-adrenergic activation on metabolic and inflammatory mediators in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Ravi K. Komaravolu, Padmaja Mehta-D’souza, Taylor Conner, Madeline Allen, Jessica Lumry, Albert Batushansky, Nathan P. Pezant, Courtney G. Montgomery, Timothy M. Griffin
Metabolic processes are intricately linked to the resolution of innate inflammation and tissue repair, two critical steps for treating post-traumatic osteoarthritis (PTOA). Based on lipolytic and immunoregulatory actions of norepinephrine, we hypothesized that intra-articular β-adrenergic receptor (βAR) stimulation would suppress PTOA-associated inflammation in the infrapatellar fat pad (IFP) and synovium
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In response to comment from E. V. Tchetina and E. A. Taskina re. ‘Association of synovial fluid and urinary C2C-HUSA levels with surgical outcomes post-total knee arthroplasty’ Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Jason S. Rockel, Amit Sandhu, Osvaldo Espin-Garcia, A. Robin Poole, Mohit Kapoor
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Response to commentary by Dvir-Ginzberg et al. Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-26 Paula A. Hernandez
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Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair Bone Res. (IF 12.7) Pub Date : 2024-03-25 Chengjun Li, Tian Qin, Jinyun Zhao, Yuxin Jin, Yiming Qin, Rundong He, Tianding Wu, Chunyue Duan, Liyuan Jiang, Feifei Yuan, Hongbin Lu, Yong Cao, Jianzhong Hu
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Do we understand sex-related differences governing dimorphic disease mechanisms in preclinical animal models of osteoarthritis? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-24 Mona Dvir-Ginzberg, Yonathan H. Maatuf, Ali Mobasheri
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Can DNA Methylation Profiling Classify Histologic Subtypes and Grades in Soft Tissue Sarcoma? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-22 Hyunho Kim, Min Wook Joo, Joohee Yoon, Hong Sik Park, June Hyuk Kim, Joo Hwan Lee, Sung Hwan Kim, Seul Ki Lee, Yang-Guk Chung, Yoon Joo Cho
A clear classification of the subtype and grade of soft tissue sarcoma is important for predicting prognosis and establishing treatment strategies. However, the rarity and heterogeneity of these tumors often make diagnosis difficult. In addition, it remains challenging to predict the response to chemotherapy and prognosis. Thus, we need a new method to help diagnose soft tissue sarcomas and determine
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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture Bone Res. (IF 12.7) Pub Date : 2024-03-21 Jie Huang, Tong Wu, Yi-Rong Jiang, Xuan-Qi Zheng, Huan Wang, Hao Liu, Hong Wang, Hui-Jie Leng, Dong-Wei Fan, Wan-Qiong Yuan, Chun-Li Song
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Are Current Survival Prediction Tools Useful When Treating Subsequent Skeletal-related Events From Bone Metastases? Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-20 Yu-Ting Pan, Yen-Po Lin, Hung-Kuan Yen, Hung-Ho Yen, Chi-Ching Huang, Hsiang-Chieh Hsieh, Stein Janssen, Ming-Hsiao Hu, Wei-Hsin Lin, Olivier Q Groot
Bone metastasis in advanced cancer is challenging because of pain, functional issues, and reduced life expectancy. Treatment planning is complex, with consideration of factors such as location, symptoms, and prognosis. Prognostic models help guide treatment choices, with Skeletal Oncology Research Group machine-learning algorithms (SORG-MLAs) showing promise in predicting survival for initial spinal
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Racial and Ethnic Minorities Underrepresented in Pain Management Guidelines for Total Joint Arthroplasty: A Meta-analysis. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-18 Katherine Merk, Nicholas C Arpey, Alba M Gonzalez, Katia E Valdez, Anna Cohen-Rosenblum, Adam I Edelstein, Linda I Suleiman
Total joint arthroplasty aims to improve quality of life and functional outcomes for all patients, primarily by reducing their pain. This goal requires clinical practice guidelines (CPGs) that equitably represent and enroll patients from all racial/ethnic groups. To our knowledge, there has been no formal evaluation of the racial/ethnic composition of the patient population in the studies that informed
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Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activation Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-15 R. Castro-Viñuelas, N. Viudes-Sarrión, A.V. Rojo-García, S. Monteagudo, R.J. Lories, I. Jonkers
Optimizing rehabilitation strategies for osteoarthritis necessitates a comprehensive understanding of chondrocytes’ mechanoresponse in both health and disease, especially in the context of the interplay between loading and key pathways involved in osteoarthritis (OA) development, like canonical Wnt signaling. This study aims to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy
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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair Bone Res. (IF 12.7) Pub Date : 2024-03-12 Heeseog Kang, Amy L. Strong, Yuxiao Sun, Lei Guo, Conan Juan, Alec C. Bancroft, Ji Hae Choi, Chase A. Pagani, Aysel A. Fernandes, Michael Woodard, Juhoon Lee, Sowmya Ramesh, Aaron W. James, David Hudson, Kevin N. Dalby, Lin Xu, Robert J. Tower, Benjamin Levi
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Exercise for knee osteoarthritis pain: Association or causation? Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-13 Marius Henriksen, Jos Runhaar, Aleksandra Turkiewicz, Martin Englund
Exercise is universally recommended as a primary strategy for the management of knee osteoarthritis (OA) pain. The recommendations are based on results from more than 100 randomized controlled trials (RCTs) that compare exercise to no-attention control groups. However, due to the inherent difficulties with adequate placebo control, participant blinding and the use of patient-reported outcomes, the
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Machine Learning Did Not Outperform Conventional Competing Risk Modeling to Predict Revision Arthroplasty. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-12 Jacobien H F Oosterhoff, Anne A H de Hond, Rinne M Peters, Liza N van Steenbergen, Juliette C Sorel, Wierd P Zijlstra, Rudolf W Poolman, David Ring, Paul C Jutte, Gino M M J Kerkhoffs, Hein Putter, Ewout W Steyerberg, Job N Doornberg
Estimating the risk of revision after arthroplasty could inform patient and surgeon decision-making. However, there is a lack of well-performing prediction models assisting in this task, which may be due to current conventional modeling approaches such as traditional survivorship estimators (such as Kaplan-Meier) or competing risk estimators. Recent advances in machine learning survival analysis might
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Microwave Ablation of the Pig Growth Plate: Proof of Concept for Minimally Invasive Epiphysiodesis. Clin. Orthop. Relat. Res. (IF 4.2) Pub Date : 2024-03-12 Samuel O Noonan, Kyle J Miller, Stephanie Goldstein, Ellen Leiferman, James White, Chris Brace, Kenneth J Noonan
Different surgical methods for epiphysiodesis of limb length discrepancy (LLD) have been described. Although these methods are variably effective, they are associated with morbidity (pain and limp) and potential complications. Microwave ablation is a less-invasive opportunity to halt growth by selectively destroying the growth plate via thermal energy to treat LLD in children.
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Brain regulates weight bearing bone through PGE2 skeletal interoception: implication of ankle osteoarthritis and pain Bone Res. (IF 12.7) Pub Date : 2024-03-05 Feng Gao, Qimiao Hu, Wenwei Chen, Jilong Li, Cheng Qi, Yiwen Yan, Cheng Qian, Mei Wan, James Ficke, Junying Zheng, Xu Cao
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Appraisal of quality and analysis of the similarities and differences between osteoarthritis Clinical Practice Guideline recommendations: A systematic review Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-05 Bimbi Gray, Alison Gibbs, Jocelyn L. Bowden, Jillian P. Eyles, Sandra Grace, Kim Bennell, Rinie Geenen, Sharon Kolasinski, Christian Barton, Philip G. Conaghan, Timothy McAlindon, Olivier Bruyere, Quentin Géczy, David J. Hunter
Clinical Practice Guidelines (CPGs) aim to support management of hip and knee osteoarthritis (OA), but recommendations are often conflicting and implementation is poor, contributing to evidence-to-practice gaps. This systematic review investigated the contextual and methodological factors contributing to conflicting recommendations for hip and knee OA. Our systematic review appraised CPGs for managing
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Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis Bone Res. (IF 12.7) Pub Date : 2024-03-04 Yuhang Liu, Ruihan Hao, Jia Lv, Jie Yuan, Xuelei Wang, Churong Xu, Ding Ma, Zhouyi Duan, Bingjun Zhang, Liming Dai, Yiyun Cheng, Wei Lu, Xiaoling Zhang
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Exploratory neutron tomography of articular cartilage Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-04 E. Tobias B. Wrammerfors, Elin Törnquist, Maria Pierantoni, Amanda Sjögren, Alessandro Tengattini, Anders Kaestner, René in ’t Zandt, Martin Englund, Hanna Isaksson
To investigate the feasibility of using neutron tomography to gain new knowledge of human articular cartilage degeneration in osteoarthritis (OA). Different sample preparation techniques were evaluated to identify maximum intra-tissue contrast. Human articular cartilage samples from 14 deceased donors (18–75 years, 9 males, 5 females) and 4 patients undergoing total knee replacement due to known OA
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Hip contact forces can be predicted with a neural network using only synthesised key points and electromyography in people with hip osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Bradley M. Cornish, Claudio Pizzolato, David J. Saxby, Zhengliang Xia, Daniel Devaprakash, Laura E. Diamond
To develop and validate a neural network to estimate hip contact forces (HCF), and lower body kinematics and kinetics during walking in individuals with hip osteoarthritis (OA) using synthesised anatomical key points and electromyography. To assess the capability of the neural network to detect directional changes in HCF resulting from prescribed gait modifications. A calibrated electromyography-informed
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Modulation of early osteoarthritis by tibiofemoral re-alignment in sheep Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-03 Jan Reinhard, Tamás Oláh, Matthias W. Laschke, Lars K.H. Goebel, Gertrud Schmitt, Susanne Speicher-Mentges, Michael D. Menger, Magali Cucchiarini, Dietrich Pape, Henning Madry
To investigate whether tibiofemoral alignment influences early knee osteoarthritis (OA). We hypothesized that varus overload exacerbates early degenerative osteochondral changes, and that valgus underload diminishes early OA. Normal, over- and underload were induced by altering alignment via high tibial osteotomy in adult sheep (n = 8 each). Simultaneously, OA was induced by partial medial anterior
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Timing is everything: Towards classification criteria for early-stage symptomatic knee osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-02 Armaghan Mahmoudian, Lauren K. King, Jean W. Liew, Qiuke Wang, C. Thomas Appleton, Martin Englund, Ida K. Haugen, L. Stefan Lohmander, Jos Runhaar, Aleksandra Turkiewicz, Tuhina Neogi, Gillian A. Hawker, on behalf of the OARSI Early-stage Symptomatic Knee Osteoarthritis Initiative
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Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis Osteoarthr. Cartil. (IF 7.0) Pub Date : 2024-03-01 Katherine M. Arnold, Samantha R. Weaver, Elizabeth L. Zars, Daniel J. Tschumperlin, Jennifer J. Westendorf
Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured with atomic force microscopy (AFM) in male and female mice after injury. Osteoarthritis was induced in male and female Wildtype (WT) and Phlpp1 mice by destabilization
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Structural validation of the Manchester-Oxford Foot Questionnaire for use in foot and ankle surgery. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Richard Goodall, Kim Borsky, Conrad J Harrison, Matt Welck, Karan Malhotra, Jeremy N Rodrigues
The Manchester-Oxford Foot Questionnaire (MOxFQ) is an anatomically specific patient-reported outcome measure (PROM) currently used to assess a wide variety of foot and ankle pathology. It consists of 16 items across three subscales measuring distinct but related traits: walking/standing ability, pain, and social interaction. It is the most used foot and ankle PROM in the UK. Initial MOxFQ validation
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Future research priorities for soft-tissue knee injuries. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Humza T Osmani, Nicolas Nicolaou, Sanjeev Anand, Jonathan Gower, , Andrew Metcalfe, Stephen McDonnell, Faraz Siddiqui, Hayley Carter, Jonathan Room, Helen Kirbyshire, Liz Hay, Sarah Iqbal, Sushilla Gerleman
To identify unanswered questions about the prevention, diagnosis, treatment, and rehabilitation and delivery of care of first-time soft-tissue knee injuries (ligament injuries, patella dislocations, meniscal injuries, and articular cartilage) in children (aged 12 years and older) and adults.
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Monobloc dual-mobility acetabular component versus a standard single-mobility acetabular component. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Sébastien Lustig, Matthieu Cotte, Constant Foissey, Rhody D Asirvatham, Elvire Servien, Cecile Batailler
The benefit of a dual-mobility acetabular component (DMC) for primary total hip arthroplasties (THAs) is controversial. This study aimed to compare the dislocation and complication rates when using a DMC compared to single-mobility (SM) acetabular component in primary elective THA using data collected at a single centre, and compare the revision rates and survival outcomes in these two groups.
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Metal artifact reduction sequence-MRI abnormalities in asymptomatic patients with dual-mobility hip prostheses. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Nathanael D Heckmann, Brian C Chung, Kevin C Liu, Xiao T Chen, Luke R Lovro, Natalie M Kistler, Eric White, Alexander B Christ, Donald B Longjohn, Daniel A Oakes, Jay R Lieberman
Modular dual-mobility (DM) articulations are increasingly used during total hip arthroplasty (THA). However, concerns remain regarding the metal liner modularity. This study aims to correlate metal artifact reduction sequence (MARS)-MRI abnormalities with serum metal ion levels in patients with DM articulations.
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Environmental and genetic risk factors associated with total knee arthroplasty following cruciate ligament surgery. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Paul M Inclan, Robert H Brophy, Nancy L Saccone, Yinjiao Ma, Vy Pham, Elizabeth L Yanik
The purpose of this study is to determine an individual's age-specific prevalence of total knee arthroplasty (TKA) after cruciate ligament surgery, and to identify clinical and genetic risk factors associated with undergoing TKA.
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Threshold for anterior acetabular component overhang correlated with symptomatic iliopsoas impingement after total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Alexandre Baujard, Pierre Martinot, Xavier Demondion, Julien Dartus, Philippe A Faure, Julien Girard, Henri Migaud
Mechanical impingement of the iliopsoas (IP) tendon accounts for 2% to 6% of persistent postoperative pain after total hip arthroplasty (THA). The most common initiator is anterior acetabular component protrusion, where the anterior margin is not covered by anterior acetabular wall. A CT scan can be used to identify and measure this overhang; however, no threshold exists for determining symptomatic
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Cardiac function may be compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Mark R J Jenkinson, Dominic R M Meek, Rothwelle Tate, Adrian Brady, Sandy MacMillan, Helen Grant, Susan Currie
Elevated blood cobalt levels secondary to metal-on-metal (MoM) hip arthroplasties are a suggested risk factor for developing cardiovascular complications including cardiomyopathy. Clinical studies assessing patients with MoM hips using left ventricular ejection fraction (LVEF) have found conflicting evidence of cobalt-induced cardiomyopathy. Global longitudinal strain (GLS) is an echocardiography measurement
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Excessive posterior pelvic tilt from preoperative supine to postoperative standing after total hip arthroplasty. Bone Joint J. (IF 4.6) Pub Date : 2024-03-01 Nathanael D Heckmann, Christopher Plaskos, Edgar A Wakelin, Jim W Pierrepont, Jonathan V Baré, Andrew J Shimmin
Excessive posterior pelvic tilt (PT) may increase the risk of anterior instability after total hip arthroplasty (THA). The aim of this study was to investigate the changes in PT occurring from the preoperative supine to postoperative standing position following THA, and identify factors associated with significant changes in PT.