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ASDAS-CRP and ASDAS-ESR cut-offs for disease activity states in axial spondyloarthritis - Are they interchangeable? J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Stylianos Georgiadis, Lykke Midtbøll Ørnbjerg, Brigitte Michelsen, Tore K Kvien, Daniela Di Giuseppe, Johan K Wallman, Jakub Závada, Sella A Provan, Eirik Klami Kristianslund, Ana Maria Rodrigues, Maria José Santos, Žiga Rotar, Katja Perdan Pirkmajer, Dan Nordström, Gary J Macfarlane, Gareth T Jones, Irene van der Horst-Bruinsma, Pasoon Hellamand, Mikkel Østergaard, Merete Lund Hetland
Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) is recommended over erythrocyte sedimentation rate (ASDAS-ESR) to assess disease activity in axial spondyloarthritis (axSpA). Although ASDAS-CRP and ASDAS-ESR are not interchangeable, the same disease activity cut-offs are used for both. We aimed to estimate optimal ASDAS-ESR values corresponding to the established ASDAS-CRP
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Upadacitinib in Rheumatoid Arthritis and Inadequate Response to Conventional Synthetic Disease-Modifying Antirheumatic Drugs: Efficacy and Safety Through 5 Years (SELECT-NEXT). J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Gerd R Burmester, Filip Van den Bosch, John Tesser, Anna Shmagel, Yanxi Liu, Nasser Khan, Heidi S Camp, Alan Kivitz
To report 5-year efficacy and safety of upadacitinib in rheumatoid arthritis (RA) from the phase 3 long-term extension (LTE) of SELECT-NEXT.
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Patient-Initiated Follow-Up. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Edward Alveyn, James Galloway, Laura C Coates
In the contemporary healthcare climate, we are acutely aware that our resources are finite. This is particularly pertinent in government-funded healthcare settings, where clinical teams often face the challenge of meeting increasing patient demand with static or dwindling capacity.1-4.
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Fibromyalgia and the Difficult Synthesis. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Marco Di Carlo, Benedetta Bianchi, Fausto Salaffi
The pathophysiological uncertainties in fibromyalgia (FM) mean that its diagnosis, to this day, remains a strictly clinical exercise. The physician's evaluation of symptoms is therefore of fundamental importance both for the correct diagnostic framing of the patient and also for guiding a personalized therapeutic approach.1.
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Knowledge of and stated adherence to the 2020 ACR Guideline for Gout Management: Results of a survey of US rheumatologists. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Naomi Schlesinger, Michael H Pillinger, Peter E Lipsky
This report evaluates rheumatologists' stated adherence to and agreement with the 2020 American College of Rheumatology (ACR) Guideline for the Management of Gout.
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When Should I Get My Next COVID Vaccine? Data from the SUrveillance of responses to COVID-19 vaCcines in systEmic immunE mediated inflammatory Diseases (SUCCEED)study. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Dawn M E Bowdish, Vinod Chandran, Carol A Hitchon, Gilaad G Kaplan, J Antonio Avina-Zubieta, Paul R Fortin, Maggie J Larché, Gilles Boire, Anne-Claude Gingras, Roya M Dayam, Ines Colmegna, Luck Lukusa, Jennifer L F Lee, Dawn P Richards, Daniel Pereira, Tania H Watts, Mark S Silverberg, Charles N Bernstein, Diane Lacaille, Jenna Benoit, John Kim, Nadine Lalonde, Janet Gunderson, Hugues Allard-Chamard
To determine how serologic responses to COVID vaccination/infection in immunemediated inflammatory disease (IMID) are affected by time since last vaccination and other factors.
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Feasibility of physiotherapist-led rheumatology triage: A randomized study. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Janet H Roberts, Cheri Gun, Jennifer E Mackinnon, Susan Parlee, Volodko Bakowsky, Trudy Taylor, Claire E H Barber, John G Hanly
Given global shortages in the rheumatology workforce, the demand for rheumatology assessment often exceeds the capacity to provide timely access to care. Accurate triage of patient referrals is important to ensure appropriate utilization of finite resources. We assessed the feasibility of physiotherapist-led triage utilizing a standardized protocol, in identifying cases of inflammatory arthritis (IA)
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High Frequency of Diffuse Idiopathic Skeletal Hyperostosis in Patients With Obesity Hypoventilation Syndrome. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-15 Shay Brikman, Reuven Mader, Amir Bieber
Diffuse idiopathic skeletal hyperostosis (DISH) is known to be associated with metabolic syndrome and with obesity in particular. The prevalence of DISH increases with age, with an average of 10% in those aged 70 years and older.
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Increased interferon signalling in vaginal tissue of patients with primary Sjögren's syndrome. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Annie Visser, Jolien F van Nimwegen, Rick Wilbrink, Silvia C Liefers, Karin van der Tuuk, Marian J E Mourits, Gilles F H Diercks, Joost Bart, Bert van der Vegt, Léon C van Kempen, Hendrika Bootsma, Frans G M Kroese, Gwenny M Verstappen
Vaginal dryness is an important factor influencing sexual function in women with primary Sjögren's syndrome (pSS). Previous studies showed a higher degree of inflammation in vaginal biopsies from pSS patients compared to non-pSS controls. However, the molecular pathways that drive this inflammation remain unclear. Therefore, the aim of this study was to investigate inflammatory pathway activity in
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School well-being and academic performance of children with juvenile idiopathic arthritis - a national register-based study. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Malthe Jessen Pedersen, Christian Høst, Stefan Nygaard Hansen, Jens Klotsche, Kirsten Minden, Bent Deleuran, Bodil Hammer Bech
We aimed to investigate how school well-being (SWB) and academic performance of children with juvenile idiopathic arthritis (JIA) compare to their peers on a national level using the Danish national registers. Further, we investigated the potential influence of socioeconomic status (SES).
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The Duty to Accommodate. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Murray Baron
As the study by Jazayeri et al in this issue of The Journal of Rheumatology points out, the prevalence of unemployment in people with systemic sclerosis (SSc) is estimated at 40.5%, and SSc is associated with "presenteeism (ie, working while unwell), lack of participation in employment, and ultimately, absenteeism."1 This is of course true of patients with the many other musculoskeletal diseases that
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Hospitalization and Mortality due to Infection among United States Children and Adolescents with Systemic Lupus Erythematosus. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Jordan E Roberts, Anna Faino, Mersine A Bryan, Jonathan D Cogen, Esi M Morgan
We aimed to determine the frequency and types of infections in hospitalized children with childhood-onset systemic lupus erythematosus (cSLE), and to identify risk factors for intensive care unit (ICU) admission and mortality.
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Phase Specific Health Care Costs Associated with Giant Cell Arteritis in Ontario, Canada. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Mats Junek, Lillian Barra, Alexander Kopp, Tina Felfeli, Jodi Gatley, Jessica Widdifield
To estimate the additional health care system costs associated with giant cell arteritis (GCA) in the year pre-diagnosis, post diagnosis, and over long-term follow up compared to individuals with similar demographics and comorbidities without GCA.
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Patients with psoriatic arthritis-related enthesitis are more likely to persist on tofacitinib under real-life conditions. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Ignacio Braña, Marta Loredo, Estefanía Pardo, Stefanie Burger, Eva Fernández-Bretón, Rubén Queiro
Information on the persistence of tofacitinib in PsA is scarce in real-life conditions. Our objective was to analyze persistence and safety of tofacitinib under these conditions.
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PanAmerican League of Associations for Rheumatology Recommendations for the Treatment of Psoriatic Arthritis. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Daniel G Fernández-Ávila, Wilson Bautista-Molano, María Lorena Brance, María Gabriela Ávila Pedretti, Rubén Burgos Vargas, José Francisco Díaz Coto, Luis Arturo Gutiérrez, Marwin Gutiérrez, Enrique Giraldo Ho, Sebastián Eduardo Ibáñez Vodnizza, Edwin Jáuregui, Vanessa Ocampo, Penélope Esther Palominos, Daniel Ruben Palleiro Rivero, Guillermo Andrés Quiceno, Fernando Andrés Sommerfleck, Luis Enrique
Psoriatic arthritis (PsA) is chronic disease that compromise multiple domains, and might be associated with progressive joint damage, increased mortality, functional limitation, and considerably impaired quality of life. Our objective is to generate evidence-based recommendations on the management of PsA in PANLAR countries.
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Lupus Nephritis Treatment Strategies. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Gabriel Nicolas Contreras Martin
Lupus nephritis (LN) is present in approximately 25% to 50% of patients at the time of systemic lupus erythematosus diagnosis and eventually develops in up to 60% of adults and 80% of children.1 Over the past 5 decades, major advances in immunosuppressive medications for patients with severe LN (classes III, IV, and V alone or in combination) have resulted in significant improvements in patient survival
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Prevalence, predictors, and prognosis of serious infections in Takayasu arteritis - a cohort study. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Durga Prasanna Misra, Upendra Rathore, Swapnil Jagtap, Prabhaker Mishra, Darpan R Thakare, Kritika Singh, Tooba Qamar, Deeksha Singh, Juhi Dixit, Manas Ranjan Behera, Neeraj Jain, Manish Ora, Dharmendra Singh Bhadauria, Sanjay Gambhir, Vikas Agarwal, Sudeep Kumar
To describe the incidence, risk factors, and outcomes associated with serious infections in patients with Takayasu arteritis (TAK).
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Association of Infant Breastfeeding and Spondyloarthritis: A Case-Control Study. J. Rheumatol. (IF 3.9) Pub Date : 2024-04-01 Katelyn Baggett, Timothy G Brandon, Rui Xiao, Pamela F Weiss
Given the multifactorial pathogenesis of juvenile spondyloarthritis (JSpA) and evidence of a protective effect in phenotypically similar diseases, we aimed to test whether breastfeeding is associated with the development and disease activity of JSpA.
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Flare in Systemic Lupus Erythematosus: Lost in Translation? J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Eric F Morand, Sarah A Jones
The concept of systemic lupus erythematosus (SLE) as a relapsing and remitting condition is deeply embedded in how clinicians perceive this disease. This perception arises from observations of periods of low disease activity interspersed with episodes of more active disease, which are commonly referred to as "flares."
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Analyzing Gender Disparities in Ankylosing Spondylitis: Exploring the Factors Behind Severe Sacroiliac Joint Disease Without Spinal Involvement. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Laura Berbel-Arcobé, Diego Benavent, Joan Miquel Nolla, Xavier Juanola
We have read with interest the paper by Ridley et al1 on the radiographic damage discordance between the sacroiliac joints (SIJs) and the spine in patients with ankylosing spondylitis (AS) from the Prospective Study of Outcomes in AS (PSOAS) cohort, which includes patients from the United States and Australia. Their results have encouraged us to investigate the prevalence of severe SIJ disease without
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Putting Patients First. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Victor S Sloan
They were some of the hardest phone calls I'd ever had to make. After more than 25 years of practice, I had to tell patients I'd been seeing for that entire period that I could no longer be their doctor.
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Perceived Access to Health Care of Indigenous Peoples in Canada with Rheumatoid Arthritis and their First-Degree Relatives. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Dana Wiens, Irene A Smolik, Dylan MacKay, Amanda Fowler-Woods, David B Robinson, Cheryl Barnabe, Hani S El-Gabalawy, Liam J O'Neil
There are complex and interrelated factors that lead to inequitable healthcare delivery in Canada. Many of the factors that underlie these inequities for Canada's geographically dispersed Indigenous Peoples remain underexamined.
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Immune Checkpoint Inhibitor associated Remitting Seronegative Symmetrical Synovitis with Pitting Edema (ICI-RS3PE): Description of a New Entity by CanRIO. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Azin Rouhi, Shahin Jamal, Lourdes Gonzales Arreola, David Moon, Marie Hudson, Janet Roberts, Alexandra Ladouceur, Carrie Ye
Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is characterized by symmetrical synovitis with pitting edema and negative rheumatoid factor (RF). It has been described in setting of malignancy, suggesting a paraneoplastic association. With the increasing use of immune checkpoint inhibitors (ICIs) for the treatment of cancers and emergence of immune related adverse event (irAEs)
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Pneumocephalus and Cerebral Abscess in Granulomatosis With Polyangiitis. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Yasutaka Okita, Masashi Okamoto, Jun Fujimoto, Atsushi Kumanogoh
Granulomatosis with polyangiitis (GPA) is a systemic autoimmune disease that causes necrotizing vasculitis of small- to medium-sized blood vessels and necrotizing granulomatous inflammation, primarily of the upper and lower respiratory system. A 33-year-old woman presented with a 16-month history of headaches, nasal obstruction, and anosmia.
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The Scleroderma Tango: Unraveling the Delicate Dance of Diastolic Dysfunction and Interstitial Lung Disease. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Vivek P Jani, Monica Mukherjee
In this issue of The Journal of Rheumatology, Fairley and colleagues investigated the effects of concomitant left ventricular diastolic dysfunction (LVDD) in a small cohort of patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) derived from the larger Australian Scleroderma Cohort Study.1 Consistent with prior reports, the authors found that patients with SSc-ILD with
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Orbital and Optic Nerve Sheath Involvement and Pupil-Involving Cranial Nerve 3 Palsy in Giant Cell Arteritis. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Salma A Dawoud, Noor-Us-Sabah Ahmad, Erin M Shriver, Sophia M Chung
Giant cell arteritis (GCA) can present with atypical presentations that are diagnostically challenging. An 84-year-old woman with a history of breast adenocarcinoma treated with lumpectomy and radiation 2 years prior presented with a seizure-like episode.
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Factors Associated with an Electronic Health Record-Based Definition of Post-Acute Sequelae of COVID-19 in Patients with Systemic Autoimmune Rheumatic Disease. J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Naomi J Patel, Xiaosong Wang, Miao Lin, Emily N Kowalski, Claire E Cook, Kathleen M M Vanni, Krishan Guzzo, Grace Qian, Katarina J Bade, Alene Saavedra, Rathnam Venkat, Shruthi Srivatsan, Zachary K Williams, Jennifer S Hanberg, Yumeko Kawano, Abigail E Schiff, Jeffrey A Sparks, Zachary S Wallace
Many individuals with rheumatic disease are at higher risk for severe acute COVID-19. We aimed to evaluate risk factors for Post-Acute Sequelae of COVID-19 (PASC) using an electronic health record (EHR)-based definition.
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Quality and Characteristics of Pediatric Rheumatology Content on Social Media: Toward a New Era of Education for Patients and Caregivers? J. Rheumatol. (IF 3.9) Pub Date : 2024-03-01 Saverio La Bella, Armando Di Ludovico, Francesca Mainieri, Federico Lauriola, Luisa Silvestrini, Francesca Ciarelli, Giulia Di Donato, Francesco Chiarelli, Marina Attanasi, Luciana Breda
Social media platforms are an extremely common form of online interaction, with more than 4.5 billion users worldwide in 2022. According to Statista.com, there is a significant expectation that this usage will exceed 6 billion by the year 2027.
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Investigating the influence of patient eligibility characteristics on the number of deferrable rheumatologist visits: planning for a patient-initiated follow-up (PIFU) strategy. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Shakeel Subdar, Kiran Dhiman, Nicole M S Hartfeld, Alison M Hoens, Krista White, Sarah L Manske, Glen Hazlewood, Diane Lacaille, Elena Lopatina, Megan R W Barber, Dianne Mosher, Aurore Fifi-Mah, Marinka Twilt, Nadia Luca, Karen L Then, Trafford Crump, Saania Zafar, Kelly Osinski, Claire E H Barber
Patient-initiated follow-up (PIFU) for rheumatoid arthritis (RA) is a model of care delivery wherein patients contact the clinic when needed instead of regularly scheduled followups. Our objective was to investigate the influence of different patient eligibility characteristics on the number of potentially deferred visits to inform future implementation of a PIFU strategy.
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Psoriatic Arthritis and COVID-19. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Hinpetch Daungsupawong, Viroj Wiwanitkit
We would like to share our ideas on the recently published article, "Psoriatic arthritis and COVID-19: Patient perspectives in a large psoriatic arthritis cohort."1 The purpose of this study was to determine the prevalence of the coronavirus disease 2019 (COVID-19) infection among patients with psoriatic arthritis (PsA), understand patients' opinions on their risk of COVID-19 infection, and evaluate
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The Association of Stair Climbing Behaviors With Hazard of All-Cause Mortality in Adults With or At Risk of Knee Osteoarthritis. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Jason T Jakiela, Dana Voinier, Jennifer A Horney, Yvonne M Golightly, Thomas K Bye, Daniel K White
To investigate the association of stair climbing difficulty and stair climbing frequency with the risk of all-cause mortality over 13 years in adults with or at high risk for knee OA.
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Short- and Long-Term Mortality of Hospitalized Patients with Autoimmune Rheumatic Diseases and Serious Infections: A National Cohort Study. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Iftach Sagy, Omer Schwarzfuchs, Lior Zeller, Eduard Ling, Amit Shira Babiev, Mahmoud Abu-Shakra
Infectious conditions are a significant cause of mortality in autoimmune rheumatic diseases (ARD). Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD.
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Real-world coverage with influenza, pneumococcal and herpes zoster vaccines among patients with rheumatic diseases in a nationwide health care plan. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Victoria Furer, Clara Weil, Gabriel Chodik, Shera Ann Slav, Shiran Naftelberg Blonder, Yonit Fisher-Shoval, Moran Barak, Ori Elkayam
Vaccination against preventable infections is important for rheumatic diseases management. This study assessed the vaccination coverage and predictors among patients with rheumatic diseases using real-world data from Israel.
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Clinical Characteristics of Adolescents with Juvenile Idiopathic Arthritis Transitioning to Adult Rheumatology Care in Canada: Results from the CAPRI Registry. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Teresa Semalulu, Roberta Berard, Karen Beattie, Daniah Basodan, Gilles Boire, Roxana Bolaria, David Cabral, Amieleena Chhabra, Tommy Gerschman, Nicole Johnson, Julie Herrington, Kristin Houghton, Lillian Lim, Paivi Maria Hannele Miettunen, Jonathan Park, Jean-Philippe Proulx-Gauthier, Heinrike Schmeling, Rosie Scuccimarri, Herman Tam, Lori Tucker, Jaime Guzman, Michelle Batthish
Using Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) JIA registry data, we describe: (1) clinical characteristics of patients with JIA transitioning to adult care, (2) their prevalence of disease-related damage and complications and, (3) changes in disease activity during the final year prior to transfer.
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Histogram-Based Densitometry Index to Assess the Severity of Interstitial Lung Disease in Systemic Sclerosis in Standard and Low-Dose Computed Tomography. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Cosimo Bruni, Lorenzo Tofani, Alexandru Garaiman, Suzana Jordan, Carmen-Marina Mihai, Rucsandra Dobrota, Muriel Elhai, Mike Oliver Becker, Anna-Maria Hoffmann-Vold, Thomas Frauenfelder, Marco Matucci-Cerinic, Oliver Distler
Mean lung attenuation, skewness, and kurtosis are histogram-based densitometry variables that quantify systemic sclerosis-associated interstitial lung disease (SSc-ILD) and were recently merged into a computerized integrated index (CII). Our work tested the CII in low-dose 9-slice (reduced) and standard high-resolution computed tomography (CT) scans to evaluate extensive SSc-ILD and predict mortality
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Systematic review and meta-analysis of pharmacological interventions in adult-onset Still's disease highlights the beneficial role of biologic DMARDs. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Piero Ruscitti, Dennis McGonagle, Viviam Canon Garcia, Hilde Rabijns, Katrin Toennessen, Mary Chappell, Mary Edwards, Paul Miller, Neil Hansell, Joe Moss, Sara Graziadio, Eugen Feist
To conduct a systematic review of the effectiveness and safety of pharmacological treatments for adult-onset Still's disease (AOSD).
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Has the Time Come? J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Yukinori Takagi
Sjögren syndrome (SS) is a chronic inflammatory autoimmune disease that primarily affects the lacrimal and salivary glands. Glandular tissue destruction progresses with disease progression, severely impairing the patient's quality of life.
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Metabolic Syndrome: A Predisposing Factor for Rheumatoid Arthritis. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Miguel Á González-Gay, Santos Castañeda, Iván Ferraz-Amaro
The term metabolic syndrome (MetS) encompasses a cluster of risk factors such as central obesity, high blood pressure, impaired fasting glucose, high triglycerides, and low high-density lipoprotein cholesterol (HDL-C), all of which are specific to cardiovascular (CV) disease.1 MetS is frequently observed in patients with rheumatoid arthritis (RA).2,3 In this regard, MetS abnormalities increase the
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Polyautoimmunity in patients with anti-cyclic citrullinated peptide antibody-positive and -negative rheumatoid arthritis: a nationwide cohort study from Denmark. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Salome Kristensen, Amalie Made Hagelskjær, René Cordtz, Sofie Bliddal, Anders Sandermann Mortensen, Claus Henrik Nielsen, Ulla Feldt-Rasmussen, Karen Buch Lauridsen, Lene Dreyer
This study aimed to compare the prevalence and incidence of polyautoimmunity between anticyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative patients with rheumatoid arthritis (RA).
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Scleritis and development of immune-mediated disease: A retrospective chart review. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Tessalyn Morrison, Moriah Gottman, Toan Do, James T Rosenbaum, Daniela Ghetie, Marcia Friedman
Scleritis may be idiopathic or caused by trauma, infections, or an immune-mediated condition. Our study aimed to understand the relationship between scleritis and immune-mediated disease, including presenting characteristics, serologies, and treatment course. Understanding these associations may allow clinicians to risk-stratify patients and predict their clinical and treatment course.
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Additional Reassuring Data for SARS-CoV-2 Vaccination in Immune-Mediated Inflammatory Diseases, but With a Catch. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Alfred H J Kim
Vaccination remains the most important intervention to attenuate the risk and severity of infectious diseases in those immunosuppressed for the treatment of rheumatic conditions and is indeed true for coronavirus disease 2019 (COVID-19). Substantial reductions in the hazard ratios (HRs) of breakthrough infections were observed in those with immune-mediated inflammatory diseases (IMIDs) vaccinated with
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Cancer risk and mortality in hospitalised patients with idiopathic inflammatory myopathies in Western Australia. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Johannes Nossent, Helen Keen, David Preen, Charles Inderjeeth
To compare cancer incidence, type and survival between patients with idiopathic inflammatory myopathies (IIMs) in Western Australia (WA) and the general population.
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Elevated Serum Levels of Zonulin Family Peptides in Anticitrullinated Protein Antibody-Positive At-Risk Individuals Without Arthritis. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Cecilia Hemgren, Klara Martinsson, Christopher Rooney, Jonas Wetterö, Kulveer Mankia, Paul Emery, Alf Kastbom
Recent advances imply that early events triggering rheumatoid arthritis (RA) occur at mucosal surfaces. We aimed to evaluate whether intestinal permeability is altered in patients at increased risk of RA, and/or predicts the development of clinical arthritis, by measuring serum zonulin family peptides (ZFP) levels, which are shown to reflect intestinal barrier integrity.
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A Call for Gene Expression Analysis in Whole Blood of Patients With Rheumatoid Arthritis (RA) as a Biomarker for RA-Associated Interstitial Lung Disease. J. Rheumatol. (IF 3.9) Pub Date : 2024-02-01 Anna Wierczeiko, Matthias Linke, Johannes Peter Friedrich, Jan Koch, Andreas Schwarting, Andreas Krause, Susanne Gerber, Alexander Gerber
Rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) is one of the most common and prognostic organ manifestations of RA. Therefore, to allow effective treatment, it is of crucial importance to diagnose RA-ILD at the earliest possible stage. So far, the gold standard of early detection has been high-resolution computed tomography (HRCT) of the lungs. This procedure involves considerable
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Systemic sclerosis in individuals with exposure to World Trade Center ground-zero rescue/recovery efforts: A case series. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Maryam Own, Aliza Bloostein, Robert Spiera, Jessica R Berman, Jacqueline Moline, Jessica K Gordon, Kimberly S Lakin
The World Trade Center (WTC) attack in New York resulted in a dust plume containing silica, hydrocarbons, and asbestos. Autoimmune disorders have been reported among those with WTC site exposure. The characteristics of those developing systemic sclerosis (SSc) have not been previously described. The purpose of this study was to describe the features of SSc patients with WTC exposure.
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The Future of COVID-19 for Patients With Immune-Mediated Inflammatory Diseases: Who Is at Risk? J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Cassandra Calabrese
For the rheumatologist, one of the greatest challenges since the start of the coronavirus disease 2019 (COVID-19) pandemic has been determining which of our patients are at greatest risk for severe COVID-19, and who should be triaged for aggressive outpatient management with preexposure prophylaxis (PrEP), additional vaccine doses, and treatment with antivirals and/or monoclonal antibody products when
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The link between dysregulated immunometabolism and vascular damage: Implications for the development of atherosclerosis in SLE and other rheumatic diseases. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Anjali S Yennemadi, Natasha Jordan, Sophie Diong, Joseph Keane, Gina Leisching
A bimodal pattern of mortality in Systemic Lupus Erythematosus (SLE) exists. Early-stage deaths are predominantly caused by infection, while later-stage deaths are caused mainly by atherosclerotic disease. Further, while SLE-related mortality has reduced considerably in recent years, cardiovascular events remain one of the leading causes of death in people with SLE. Accelerated atherosclerosis in SLE
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Does Changing Anticyclic Citrullinated Protein Testing From Restricted Ordering to Open Ordering Affect Healthcare Utilization and the Rate of Positive Testing? J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Diane Ramsay, Trudy Taylor
Rheumatoid arthritis (RA) is the most common inflammatory arthritis, and left untreated, can lead to irreversible joint or extraarticular damage.1 Patients with RA are diagnosed through a combination of clinical, radiographic, and laboratory findings, based on the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria.1 Delays in
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Patient Reported Impact Of Symptoms In Fibromyalgia (PRISM-FM). J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Jennifer Weinstein, Spencer Rosero, Jamison Seabury, Anika Varma, Charlotte Engebrecht, Shaweta Khosa, John Heatwole, Nuran Dilek, Aaron Kaat, Chad Heatwole
To identify the frequency and relative importance of symptoms experienced by adults with fibromyalgia (FM) and determine factors associated with a higher disease burden.
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Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis: A Prospective Cohort Study Including 369,065 Participants. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Peiyang Luo, WanLi Xu, Ding Ye, Weiwei Chen, Jiacheng Ying, Bin Liu, Jiayu Li, Xiaohui Sun, Zhixing He, Chengping Wen, Yingying Mao
To explore the associations between metabolic syndrome (MetS) and its individual components and the risk of rheumatoid arthritis (RA).
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Axial spondyloarthritis treatment recommendations and disease activity monitoring in clinical practice - results of an online survey. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Stephanie Sinnappan, Alexandra Forte, Joerg Ermann
Clinical practice guidelines are not always followed consistently. To better understand potential barriers to the implementation of treatment recommendations in axial spondyloarthritis and ankylosing spondylitis (axSpA/AS) an online survey was performed.
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Role of Creation of Plain Language Summaries to Disseminate COVID-19 Research Findings to Patients With Rheumatic Diseases. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Mithu Maheswaranathan, Akpabio Akpabio, Laura-Ann Tomasella, Ariella Coler-Reilly, Dawn P Richards, Richard A Howard, Monique Gore-Massy, Nadine Ladone, Emily Sirotich
Dissemination of accurate scientific and medical information was critical during the coronavirus disease 2019 (COVID-19) pandemic, particularly during the early phases when little was known about the disease. Unfortunately, poor science literacy is a serious public health problem, contributing to widespread difficulties in accurately interpreting information and scientific data during the ongoing COVID-19
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A Good Response to Nonsteroidal Antiinflammatory Drugs Does Not Discriminate Patients With Longstanding Axial Spondyloarthritis From Controls With Chronic Back Pain. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Xenofon Baraliakos, Elena Bergmann, Styliani Tsiami, Imke Redeker, Jürgen Braun
To compare the response to nonsteroidal antiinflammatory drugs (NSAIDs) in patients with longstanding axial spondyloarthritis (axSpA) and controls with back pain (nonspondyloarthritis [non-SpA]).
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Association of serum soluble transferrin receptor concentration with markers of inflammation - analysis of 1001 patients from a tertiary rheumatology center. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Florian Günther, Rainer H Straub, Wolfgang Hartung, Martin Fleck, Boris Ehrenstein, Louisa Schminke
Soluble transferrin receptor (sTfR) is considered to be a useful biomarker for the diagnosis of iron deficiency (ID), especially in the setting of inflammation as it is thought to be not affected by inflammation. We analysed the relationship between sTfR levels and inflammatory markers in patients with known or suspected inflammatory rheumatic disease (IRD).
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Relationship between adalimumab concentrations, anti-drug antibodies and disease activity in rheumatoid arthritis: a cross-sectional observational study. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Lisa K Stamp, Paula Keating, Christopher Frampton, Murray L Barclay, Niamh Fanning, Melanie Millier, Paul A Hessian, John L O'Donnell
To determine the influence of patient characteristics and disease activity, on adalimumab concentrations and to assess the relationships between adalimumab concentrations, the presence of anti-drug antibodies (ADAs) and disease activity in rheumatoid arthritis (RA) and to determine the association between cytokine concentrations and adalimumab concentrations.
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Are Electronic Health Records Sufficiently Accurate to Phenotype Rheumatology Patients With Chronic Pain? J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Hance Clarke, Mary-Ann Fitzcharles
Chronic pain in rheumatic diseases (RDs), a symptom often neglected, is prevalent and an important contributor to poor health and reduced quality of life. Various studies report that up to a third of patients with inflammatory RDs have persistent pain, often attributed to pain sensitization, even when the underlying disease is controlled.1-3.
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Contribution of left ventricular diastolic dysfunction to survival and breathlessness in systemic sclerosis interstitial lung disease. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Jessica L Fairley, Dylan Hansen, Andrew Burns, David Prior, André La Gerche, Kathleen Morrisroe, Wendy Stevens, Mandana Nikpour, Laura Ross
To explore the impact of left ventricular diastolic dysfunction (LVDD) in systemic-sclerosis (SSc)-associated interstitial lung disease (ILD), and to investigate SSc-specific associations and clinical correlates of LVDD.
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Patient-reported outcomes and PRO remission rates in 12,262 biologic-naïve patients with psoriatic arthritis treated with TNF-inhibitors in routine care. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Lykke Midtbøll Ørnbjerg, Kathrine Rugbjerg, Stylianos Georgiadis, Simon Horskjær Rasmussen, Lennart Jacobsson, Anne Gitte Loft, Florenzo Iannone, Karen Minde Fagerli, Jiri Vencovsky, Maria José Santos, Burkhard Möller, Manuel Pombo-Suarez, Ziga Rotar, Bjorn Gudbjornsson, Ayse Cefle, Kari Eklund, Catalin Codreanu, Gareth Jones, Marleen van der Sande, Johan Karlsson Wallman, Marco Sebastiani, Brigitte
To evaluate patient-reported outcomes (PROs) after initiation of tumor necrosis factor inhibitor (TNFi) treatment in European real-world patients with psoriatic arthritis (PsA). Further, to investigate PRO remission rates across treatment courses, registries, disease duration, sex and age at disease onset.
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Rheumatoid arthritis: The continuum of disease and strategies for prediction, early intervention and prevention. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Liam J O'Neil, Deshiré Alpízar-Rodríguez, Kevin D Deane
Rheumatoid arthritis (RA) is known to include a 'pre-RA' stage that can be defined as the presence of familial or genetic risk factors, biomarker abnormalities (e.g. autoantibodies to citrullinated peptide antigens [ACPA]), symptoms and even abnormal imaging findings prior to the development of the onset of 'clinical RA' with inflammatory arthritis that is apparent on physical examination. Indeed,
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Preliminary Development of a Novel Tool to Document Vessel Wall Involvement in Patients With Large-Vessel Vasculitis. J. Rheumatol. (IF 3.9) Pub Date : 2024-01-15 Timothy S H Kwok, Alan L Zhou, Emily Lan-Vy Nguyen, Andrew Kwan, Razan A Al-Yaarubi, Taraneh Tofighi, Natasha K Gakhal, Shirley Lake, Medha Soowamber
Vascular imaging plays an important role in baseline assessment and monitoring disease progression in large-vessel vasculitis (LVV).1 However, interpretation and documentation of vessel wall involvement can be challenging due to a lack of standardized radiology reporting frameworks and unfamiliarity with vascular anatomy among rheumatologists.2,3.