The FDA’s decision, expected this month, follows several setbacks and delays and will pose difficult choices for the families of children with Duchenne muscular dystrophy.

The most comprehensive census yet reveals that there could be twice as many of the invasive animals than previous estimates indicated.

World’s largest survey of Pacific corals clocked 100,000 kilometres, collecting 58,000 samples from 249 locations including Indonesia, Japan and Papua New Guinea.

High thermoelectric performance is generally achieved in solid-solution alloyed or heavily doped semiconductors. The consequent atomic disorder has a trade-off in the thermoelectric figure of merit, zT: lattice thermal conductivity decreases with increasing disorder, charge carrier mobility also reduces simultaneously. Herein, we demonstrate a strategy to optimize disorder rooted in the thermodynamic

Supporting Information (PDF). We inadvertently included the incorrect 1H NMR and 13C NMR spectra for compounds YT117R and YT117S. We have updated the Supporting Information with the correct spectra and also included chiral supercritical fluid chromatography traces for these compounds. We also corrected the compound numbers in Figure S6 to read YT47R and YT47S. The Supporting Information is available

When a defined protein/peptide (or combinations thereof) control and define the synthesis of an inorganic nanoparticle, the result is a cloneable NanoParticle (cNP). This is because the protein sequence/structure/function is encoded in DNA, and therefore the physicochemical properties of the nanoparticle are also encoded in DNA. Thus the cloneable nanoparticle paradigm can be considered as an extension

Radiotherapy as one of most important cancer treatment modalities has been widely used in the therapy of various cancers. The clinically used radiation (e.g. X-ray) for radiotherapy has the advantages of precise spatiotemporal controllability and deep tissue penetration. However, traditional radiotherapy has been frequently limited by the high side effects and tumor hypoxia. The combination of radiotherapy

In miniaturized electronic and optoelectronic circuits, molecular tunnel junctions have attracted enormous research interest due to their small footprint, low power consumption, and rich molecular functions. However, the most popular building blocks used in contemporary molecular tunnel junctions are thiol molecules, which attach to electrode surfaces via a metal-thiolate (M-S) bond, showing low stability

Herein, we report the synthesis of a sterically distorted distibene ([4]2) and its transition-metal-like reactivity towards two fundamental feedstock chemicals: H2 and ethylene. Although [4]2 exhibits an unusually long Sb=Sb distance and noticeable backbone distortion in the solid state, NMR data suggest that [4]2 remains predominantly as a dimer in solution, even at high temperatures. However, it

The development of novel polymerization capable of yielding polymers with low molecular weight distribution (Đ) is essential and significant in polymer chemistry, where monofunctional initiator contains only one initiation site in these polymerizations generally. Here, ketyl radical anion species is introduced to develop a novel Ketyl Mediated Polymerization (KMP), which enables radical polymerization

Defect is one of the key factors limiting optoelectronic performances of organic-inorganic hybrid systems. Although high-efficiency bidentate ligands based electroluminescent (EL) clusters reported, until present, only few EL clusters based on monodentate ligands were realized, since their structural unstability induces more surface/interface defects. Herein, this bottleneck is firstly overcome in

Perovskite heterojunctions are essential components of perovskite optoelectronics, but their construction and investigation have been impeded by the instability and severe anion interdiffusion. Here we epitaxially deposited p-type CsPbBr3 on n-type Nb: SrTiO3 (STO) to construct a functional perovskite heterojunction with high stability. The lattice match allowed the epitaxial growth of CsPbBr3 to occur

Solid-state batteries can ensure high energy density and safety in lithium metal batteries, while polymer electrolytes are plagued by slow ion kinetics and low selective transport of Li+. Metal-organic frameworks (MOFs) have been proposed as emerging fillers for solid-state poly(ethyleneoxide)(PEO) electrolytes, however, developing functionalized MOFs and understanding their roles on ion transfer has

Epithelial cysts and organoids are multicellular hollow structures formed by correctly polarized epithelial cells. Important in steering these cysts from single cells is the dynamic regulation of extracellular matrix presented ligands, and matrix dynamics. Here, we introduce control over the effective ligand concentration, decoupled from bulk and local mechanical properties, in synthetic dynamic supramolecular

Cancer-associated fibroblasts (CAFs) promote cancer stem cell (CSC)-mediated chemoresistance and immunosuppressive tumor microenvironment. However, direct depletion of CAFs may increase cancer invasiveness and metastasis. As a generalized strategy against chemoresistant cancers, we design Gemini-like homotypic targeting nanoparticles (NPs) for two-pronged CAF transformation and cancer cell elimination

The vital role of metabolites across all branches of life and their involvement in various disorders have been investigated for decades. Many metabolites are poorly soluble in water or in physiological buffers and tend to form supramolecular aggregates. On the other hand, in the cell, they should be preserved in a pool and be readily available for the execution of biochemical functions. We thus propose

Enantioselective functionalization of racemic alkyl halides is an efficient strategy to assemble complex chiral molecules, but remains one of the biggest challenges in organic chemistry. The distant and selective activation of unreactive C−H bonds in alkyl halides has received growing interest as it enables rapid generation of molecular complexity from simple building blocks. Here, we reported a cobalt-catalyzed

Covalent organic frameworks (COFs) are crystalline porous organic materials that hold a wealth of potential applications across various fields. The development of COFs, however, is significantly impeded by the dearth of efficient synthetic methods. The traditional solvothermal approach, while prevalent, is fraught with challenges such as complicated processes, excessive energy consumption, long reaction

It is challenging to achieve stable and efficient radical emissions under ambient conditions. Herein, we present a rational design strategy to protect photoinduced carbonyl free radical emission through electrostatic interaction and spin delocalization effect. The host-guest system is constructed via tricarbonyl-substituted benzene molecules and a series of imidazolium ionic liquids as the guest and

Chiral amines are broadly used compounds in pharmaceutical industry and organic synthesis, and reductive amination reactions have been the most appreciated methods for their syntheses. However, one-step transfer hydrogenative direct asymmetric reductive amination (THDARA) that could expand the scope, simplify the operation and eliminate the use of additives has been challenging. In this work, based

Sluggish oxygen evolution kinetics and serious charge recombination restrict the development of photoelectrochemical (PEC) water splitting. The advancement of novel metal-organic frameworks (MOFs) catalysts bears practical significance for improving PEC water splitting performance. Herein, a MOF glass catalyst through melting glass-forming cobalt-based zeolitic imidazolate framework (Co-agZIF-62) was

Numerous indole alkaloids such as the iboga- and aspidosperma-type are believed to be biosynthesized via a common hypothetical intermediate, dehydrosecodine. The highly reactive nature of dehydrosecodine-type compounds has hampered their isolation and structural elucidation. In this study, we achieved the first X-ray structural determination of a dehydrosecodine-type compound by integrating synthetic

Layered MXenes are normally obtained by chemically etching the A element of MAX phases (M is the early transition element, A is the main group element, and X is nitrogen or carbon) by using fluoride-containing compounds or a Lewis acidic molten salt (LAMS) for example. After removing the A element in the MAX phase, the exposed M atoms can spontaneously coordinate with anions, such as F–, O2–, OH– or

Chemically treated and coated paper, as well as cellulose fibres reconstituted from wood, have been used to make a variety of low-cost, printable electronic devices such as solar cells and battery electrodes, and woody materials have been the source of porous activated carbons for devices such as electrochemical capacitors1. The performance might not always equal that of more highly engineered materials

The Materials Research Society, which celebrates its 50th anniversary this year, has long been a central hub for the materials community.

Andrew Robinson reviews five of the best science picks.

Nature marked International Women’s Day by asking readers how to achieve gender equality in science.

Some academics have welcomed the proposed open-access plans. But publishing-industry representatives warn they are unrealistic and lack detail.

Scientists from these communities mark the start of Pride Month by describing how colleagues and collaborators can better support them in lab and fieldwork settings.

Strongly flowing winds are detected inside a bright spot at the giant planet’s north pole.

UAE's MBR Explorer aims to solve mystery of ultra-red celestial body in the asteroid belt beyond Mars.