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Investigation of genomic and pathogenicity characteristics of Streptococcus suis ST1 human strains from Guangxi Zhuang Autonomous Region (GX) between 2005 and 2020 in China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-21 Weiming Kang, Mingliu Wang, Xueli Yi, Jianping Wang, Xiyan Zhang, Zongfu Wu, Yan Wang, Hui Sun, Marcelo Gottschalk, Han Zheng, Jianguo Xu
Streptococcus suis is a significant and emerging zoonotic pathogen. ST1 and ST7 strains are the primary agents responsible for S. suis human infections in China, including the Guangxi Zhuang Autono...
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Invasive pneumococcal diseases in Chinese children: a multicenter hospital based active surveillance from 2019-2021 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-22 Xue Ning, Lianmei Li, Jing Liu, Fang Wang, Kun Tan, Wenhui Li, Kai Zhou, Shujun Jing, Aiwei Lin, Jing Bi, Shiyong Zhao, Huiling Deng, Chunhui Zhu, Shanshan Lv, Juan Li, Jun Liang, Qing Zhao, Yumin Wang, Biquan Chen, Liang Zhu, Guowu Shen, Jianlong Liu, Zhi Li, Jikui Deng, Xin Zhao, Mingfeng Shan, Yi Wang, Shihua Liu, Tingting Jiang, Xuexia Chen, Yufeng Zhang, Sha Cai, Lixue Wang, Xudong Lu, Jinghui
This study aimed to provide data for the clinical features of invasive pneumococcal disease (IPD) and the molecular characteristics of Streptococcus pneumoniae isolates from pediatric patients in C...
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Transmission of blaNDM in Enterobacteriaceae among animals, food and human Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-20 Bo Fu, Jian Xu, Dandan Yin, Chengtao Sun, Dejun Liu, Weishuai Zhai, Rina Bai, Yue Cao, Qin Zhang, Shizhen Ma, Timothy R. Walsh, Fupin Hu, Yang Wang, Congming Wu, Jianzhong Shen
Despite carbapenems not being used in animals, carbapenem-resistant Enterobacterales (CRE), particularly New Delhi metallo-β-lactamase-producing CRE (NDM-CRE), are prevalent in livestock. Concurren...
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Rodent control strategies and Lassa virus: some unexpected effects in Guinea, West Africa Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-20 Joachim Mariën, Mickaël Sage, Umaru Bangura, Alicia Lamé, Michel Koropogui, Toni Rieger, Barré Soropogui, Moussa Douno, N’Faly Magassouba, Elisabeth Fichet-Calvet
The Natal multimammate mouse (Mastomys natalensis) is the host of Lassa mammarenavirus, causing Lassa haemorrhagic fever in West Africa. As there is currently no operational vaccine and therapeutic...
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Small regulatory RNA RSaX28 promotes virulence by reinforcing the stability of RNAIII in community-associated ST398 clonotype Staphylococcus aureus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-20 Ying Jian, Tianchi Chen, Ziyu Yang, Guoxiu Xiang, Kai Xu, Yanan Wang, Na Zhao, Lei He, Qian Liu, Min Li
Staphylococcus aureus (S. aureus) is a notorious pathogen that cause metastatic or complicated infections. Hypervirulent ST398 clonotype strains, remarkably increased in recent years, dominated Com...
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Detection and phylogenetic analysis of contemporary H14N2 Avian influenza A virus in domestic ducks in Southeast Asia (Cambodia) Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-17 Jurre Y. Siegers, Michelle Wille, Sokhoun Yann, Songha Tok, Sarath Sin, Sokha Chea, Alice Porco, Sreyem Sours, Vutha Chim, Samban Chea, Kimtuo Chhel, Sothyra Tum, San Sorn, Makara Hak, Peter Thielen, Vijaykrishna Dhanasekaran, Erik A. Karlsson
Avian influenza virus (AIV) in Asia is a complex system with numerous subtypes and a highly porous wild birds-poultry interface. Certain AIV subtypes, such as H14, are underrepresented in current s...
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Genomic and eco-epidemiological investigations in Uruguay reveal local Chikungunya virus transmission dynamics during its expansion across the Americas in 2023 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Analía Burgueño, Marta Giovanetti, Vagner Fonseca, Noelia Morel, Mauricio Lima, Emerson Castro, Natália R. Guimarães, Felipe C. M. Iani, Victoria Bormida, Maria Noel Cortinas, Viviana Ramas, Leticia Coppola, Ana I. Bento, Leticia Franco, Jairo Mendez Rico, José Lourenço, Luiz Carlos Junior Alcantara, Hector Chiparelli
Uruguay experienced its first Chikungunya virus outbreak in 2023, resulting in a significant burden to its healthcare system. We conducted analysis based on real-time genomic surveillance (30 novel...
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Clinical outcomes of treatment-naïve HBeAg-negative patients with chronic hepatitis B virus infection with low serum HBsAg and undetectable HBV DNA Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-16 Jian Wang, Li Zhu, Shaoqiu Zhang, Zhiyi Zhang, Tao Fan, Fei Cao, Ye Xiong, Yifan Pan, Yuanyuan Li, Chao Jiang, Shengxia Yin, Xin Tong, Yali Xiong, Juan Xia, Xiaomin Yan, Yong Liu, Xingxiang Liu, Yuxin Chen, Jie Li, Chuanwu Zhu, Chao Wu, Rui Huang
Serum hepatitis B surface antigen (HBsAg) level < 100 IU/ml and undetectable hepatitis B virus (HBV) DNA have been recently proposed as an alternate endpoint of “partial cure” in chronic hepatitis ...
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Mammalian adaptation risk in HPAI H5N8: a comprehensive model bridging experimental data with mathematical insights Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-16 Santosh Chokkakula, Sol Oh, Won-Suk Choi, Chang Il Kim, Ju Hwan Jeong, Beom Kyu Kim, Ji-Hyun Park, Seong Cheol Min, Eung-Gook Kim, Yun Hee Baek, Young Ki Choi, Min-Suk Song
Understanding the mammalian pathogenesis and interspecies transmission of HPAI H5N8 virus hinges on mapping its adaptive markers. We used deep sequencing to track these markers over five passages i...
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Evolution of H7N9 highly pathogenic avian influenza virus in the context of vaccination Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-17 Yujie Hou, Guohua Deng, Pengfei Cui, Xianying Zeng, Bin Li, Dongxue Wang, Xinwen He, Cheng Yan, Yaping Zhang, Jiongjie Li, Jinming Ma, Yanbing Li, Xiurong Wang, Guobin Tian, Huihui Kong, Lijie Tang, Yasuo Suzuki, Jianzhong Shi, Hualan Chen
Human infections with the H7N9 influenza virus have been eliminated in China through vaccination of poultry; however, the H7N9 virus has not yet been eradicated from poultry. Carefully analysis of ...
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Chromosomal integration and plasmid fusion occurring in ST20 carbapenem-resistant Klebsiella pneumoniae isolates coharboring blaNDM-1 and blaIMP-4 induce resistance transmission and fitness variation Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-16 Qiucheng Shi, Huangdu Hu, Qian Yu, Weiyi Huang, Yinping Wang, Jingjing Quan, Junxin Zhou, Rui Weng, Ping Zhang, Yan Meng, Haiyang Liu, Yan Jiang, Yunsong Yu, Xiaoxing Du
To investigate the epidemiology of ST20 carbapenem-resistant Klebsiella pneumoniae (CRKP) in China, and further explore the genomic characteristics of blaIMP-4 and blaNDM-1 coharboring isolates and...
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Amino acids in the polymerase complex of shorebird-isolated H1N1 influenza virus impact replication and host-virus interactions in mammalian models Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-14 Yaqin Bai, Hui Lei, Wenjun Song, Sang-Chul Shin, Jiaqi Wang, Biying Xiao, Zeynep A. Koçer, Min-Suk Song, Robert Webster, Richard J. Webby, Sook-San Wong, Mark Zanin
A diverse population of avian influenza A viruses (AIVs) are maintained in wild birds and ducks yet the zoonotic potential of AIVs in these environmental reservoirs and the host-virus interactions ...
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The African swine fever virus MGF300-4L protein is associated with viral pathogenicity by promoting the autophagic degradation of IKKβ and increasing the stability of IκBα Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-14 Tao Wang, Rui Luo, Jing Zhang, Jing Lan, Zhanhao Lu, Huanjie Zhai, Lian-Feng Li, Yuan Sun, Hua-Ji Qiu
African swine fever (ASF) is a highly contagious, often fatal viral disease caused by African swine fever virus (ASFV), which imposes a substantial economic burden on the global pig industry. When ...
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Evaluation of analytical performance of the STANDARDTM M10 MPX/OPX assay for the simultaneous DNA detection and clade attribution of Monkeypox virus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-14 Alessandro Mancon, Angelo Roberto Raccagni, Gloria Gagliardi, Davide Moschese, Alberto Rizzo, Andrea Giacomelli, Miriam Cutrera, Federica Salari, Fiorenza Bracchitta, Spinello Antinori, Andrea Gori, Giuliano Rizzardini, Antonella Castagna, Maria Rita Gismondo, Silvia Nozza, Davide Mileto
Monkeypox virus (MPXV) infection confirmation needs reliable polymerase chain reaction (PCR) assays; in addition, viral clade attribution is a key factor in containment measures, considering a more...
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Modeling the spatial risk of malaria through probability distribution of Anopheles maculipennis s.l. and imported cases Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Shirin Taheri, Mikel Alexander González, María José Ruiz-López, Sergio Magallanes, Sarah Delacour-Estrella, Javier Lucientes, Rubén Bueno-Marí, Josué Martínez-de la Puente, Daniel Bravo-Barriga, Eva Frontera, Alejandro Polina, Yasmina Martinez-Barciela, José Manuel Pereira, Josefina Garrido, Carles Aranda, Alfonso Marzal, Ignacio Ruiz-Arrondo, José Antonio Oteo, Martina Ferraguti, Rafael Gutíerrez-López
Malaria remains one of the most important infectious diseases globally due to its high incidence and mortality rates. The influx of infected cases from endemic to non-endemic malaria regions like E...
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Efficacy of Genotype-matched Vaccine Against Re-emerging Genotype V Japanese Encephalitis Virus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Jae-Deog Kim, Ah-Ra Lee, Dah-Hyun Moon, Young-Uk Chung, Su-Yeon Hong, Hyo Je Cho, Tae Hyun Kang, Yo Han Jang, Myung Hyun Sohn, Baik-Lin Seong, Sang-Uk Seo
Japanese encephalitis (JE), caused by the Japanese encephalitis virus (JEV), is a highly threatening disease with no specific treatment. Fortunately, the development of vaccines has enabled effecti...
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Antigenicity assessment of SARS-CoV-2 saltation variant BA.2.87.1 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-15 Sijie Yang, Yuanling Yu, Fanchong Jian, Ayijiang Yisimayi, Weiliang Song, Jingyi Liu, Peng Wang, Yanli Xu, Jing Wang, Xiao Niu, Lingling Yu, Yao Wang, Fei Shao, Ronghua Jin, Youchun Wang, Yunlong Cao
Published in Emerging Microbes & Infections (Just accepted, 2024)
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Rat hepatitis E virus (Rocahepevirus ratti) exposure in cats and dogs, Hong Kong Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-12 Estie Hon-Kiu Shun, Jianwen Situ, James Yiu-Hung Tsoi, Shusheng Wu, Jianpiao Cai, Kelvin Hon-Yin Lo, Nicholas Foo-Siong Chew, Zhiyu Li, Rosana Wing-Shan Poon, Jade Lee-Lee Teng, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Siddharth Sridhar
Hepatitis E virus (HEV) variants infecting humans belong to two species: Paslahepevirus balayani (bHEV) and Rocahepevirus ratti (rat hepatitis E virus; rHEV). R. ratti is a ubiquitous rodent pathog...
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Long-term co-circulation of multiple influenza A viruses in pigs, Guangxi, China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-09 Chongqiang Huang, Liangzheng Yu, Yi Xu, Jiamo Huang, Yibin Qin, Xuan Guo, Yongfang Zeng, Yifeng Qin, Kang Ouyang, Zuzhang Wei, Weijian Huang, Adolfo García-Sastre, Ying Chen
Influenza A viruses (IAVs) pose a persistent potential threat to human health because of the spillover from avian and swine infections. Extensive surveillance was performed in 12 cities of Guangxi,...
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Unveiling the pathogenic mechanisms of Clostridium perfringens toxins and virulence factors Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-09 Anny Camargo, Juan David Rámirez, Raymond Kiu, Lindsay J. Hall, Marina Muñoz
Clostridium perfringens causes multiple diseases in humans and animals. Its pathogenic effect is supported by a broad and heterogeneous arsenal of toxins and other virulence factors associated with...
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Evolution of H6N6 viruses in China between 2014 and 2019 involves multiple reassortment events Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-06 Yingying Du, Jun Xia, Zhengxiang Wang, Jie Xu, Yanhong Ji, Yinghong Jin, Ling Pu, Shuai Xu
H6N6 avian influenza viruses (AIVs) have been widely detected in wild birds, poultry, and even mammals. Recently, H6N6 viruses were reported to be involved in the generation of H5 and H7 subtype vi...
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Serum IL-17A and IL-6 in paediatric Mycoplasma pneumoniae pneumonia: implications for different endotypes Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-04 Heng Wang, Yanli Zhang, Chengsong Zhao, Yun Peng, Wenqi Song, Weihan Xu, Xiaohui Wen, Jinrong Liu, Haiming Yang, Ruihe Shi, Shunying Zhao
Paediatric Mycoplasma pneumoniae pneumonia (MPP) is a heterogeneous disease with a diverse spectrum of clinical phenotypes. No studies have demonstrated the relationship between underlying endotype...
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Prevalence and characteristics of ertapenem-mono-resistant isolates among carbapenem-resistant Enterobacterales in China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-03 Yinping Wang, Huangdu Hu, Qiucheng Shi, Ping Zhang, Dongdong Zhao, Yan Jiang, Yunsong Yu
Carbapenem-resistant Enterobacterales (CRE), specifically those resistant to only ertapenem among carbapenems (ETP-mono-resistant), are increasingly reported, while the optimal therapy options rema...
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Immunogenicity and protective efficacy of inactivated coxsackievirus B4 viral particles Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-05 Tingfeng Wang, Chiyuan Wang, Lili Pang, Yujie Zhang, Shuxia Wang, Xiaozhen Liang, Zhong Huang
Coxsackievirus B4 (CVB4) is associated with a range of acute and chronic diseases such as hand, foot, and mouth disease, myocarditis, meningitis, pancreatitis, and type 1 diabetes, affecting millio...
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Peripheral nerve injury associated with JEV infection in high endemic regions, 2016-2020: a multicenter retrospective study in China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-05 Guowei Wang M.M., Lianmei Zhong M.D., Manxia Wang M.D., Juan Zhou M.D., Shuting Liu M.S., Wang Miao M.D., Leilei Li M.D., Yonghong Liu M.D., Shougang Guo M.D., Haining Li M.D., Xiaoming Wang M.M., Liuqing Xie M.M., Min Xie M.M., Shihong Fu B.S., Tingting Xuan M.M., Fan Li Ph.D., Tingting Yang M.Sc., Lufei Shao M.M., Mingfang Shi M.B., Xiaocong Li M.M., Xiaoling Li M.D., Li Gao M.M., Shaopeng Zhai M
Previously, we have reported a cohort of Japanese encephalitis (JE) patients with Guillain–Barré syndrome. However, the evidence linking Japanese encephalitis virus (JEV) infection and peripheral n...
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Mycoplasma pneumoniae at the rise not only in China: rapid increase of Mycoplasma pneumoniae cases also in Spain Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-04-03 Ana Dacosta Urbieta, Gema Barbeito Castiñeiras, Irene Rivero Calle, Jacobo Pardo Seco, Carmen Rodríguez Tenreiro, Ricardo Suárez Camacho, María Luisa Pérez del Molino Bernal, Federico Martinón Torres
After the use of facemasks, other isolation measures enacted during the SARS-CoV-2 pandemic were lifted, respiratory pathogens, such as RSV, reappeared, but until the November 2023 WHO alert for Ch...
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Rapid identification of A29L antibodies based on mRNA immunization and high-throughput single B cell sequencing to detect Monkeypox virus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-31 Huisheng Sun, Yiqi Miao, Xingsheng Yang, Liang Guo, Qingyu Li, Jing Wang, Jinrong Long, Zhen Zhang, Jingqi Shi, Jian Li, Yiming Cao, Changxiao Yu, Jierui Mai, Zhen Rong, Jiannan Feng, Shumei Wang, Jing Yang, Shengqi Wang
With the large number of atypical cases in the mpox outbreak, which was classified as a global health emergency by the World Health Organization (WHO) on 23 July 2022, rapid diagnosis of mpox and d...
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Mpox virus Clade IIb infected Cynomolgus macaques via mimic natural infection routes closely resembled human mpox infection Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-29 Qingni Li, Yunfeng Chen, Wenjing Zhang, Chunyang Li, Ding Tang, Wanlu Hua, Fan Hou, Zhuo Chen, Yuanlang Liu, Yi Tian, Kaili Sun, Xiuli Xu, Yan Zeng, Fei Xia, Jia Lu, Zejun Wang
Generating an infectious non-human primate (NHP) model using a prevalent monkeypox virus (MPXV) strain has emerged as a crucial strategy for assessing the efficacy of vaccines and antiviral drugs a...
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Coinfection and nonrandom recombination drive the evolution of swine enteric coronaviruses Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-27 Jiahui Guo, Yinan Lai, Zhixiang Yang, Wenbo Song, Junwei Zhou, Zhuang Li, Wen Su, Shaobo Xiao, Liurong Fang
Coinfection with multiple viruses is a common phenomenon in clinical settings and is a crucial driver of viral evolution. Although numerous studies have demonstrated viral recombination arising fro...
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Human monoclonal antibody F61 nasal spray effectively protected high-risk populations from SARS-CoV-2 variants during the COVID-19 pandemic from late 2022 to early 2023 in China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-26 Ying Liu, Jiayou Zhang, Wen Liu, Yongbing Pan, Shunan Ruan, Xuanxuan Nian, Wei Chen, Lina Sun, Qiangling Yin, Xin Yue, Qingliang Li, Fang Gui, Cong Wu, Shuzhen Wang, Yunkai Yang, Zhaofei Jing, Feiguang Long, Zejun Wang, Zeyu Zhang, Chaolin Huang, Kai Duan, Mifang Liang, Xiaoming Yang
Following the national dynamic zero-COVID strategy adjustment, the utilization of broad-spectrum nasal neutralizing antibodies may offer an alternative approach to controlling the outbreak of Omicr...
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Characterization of the diversity of type IV secretion system-encoding plasmids in Acinetobacter Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-26 Farah Nasser, Avery Gaudreau, Shareefah Lubega, Arvin Zaker, Xuhua Xia, Arvind S. Mer, Vanessa M. D’Costa
The multi-drug resistant pathogen Acinetobacter baumannii has gained global attention as an important clinical challenge. Owing to its ability to survive on surfaces, its capacity for horizontal ge...
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Establishment of a human organoid-based evaluation system for assessing interspecies infection risk of animal-borne coronaviruses Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-26 Qianchun Gong, Rendi Jiang, Lina Ji, Haofeng Lin, Meiqin Liu, Xiaofang Tang, Yong Yang, Wei Han, Jing Chen, Zishuo Guo, Qi Wang, Qian Li, Xi Wang, Tingting Jiang, Shizhe Xie, Xinglou Yang, Peng Zhou, Zhengli Shi, Xinhua Lin
The COVID-19 pandemic presents a major threat to global public health. Several lines of evidence have shown that the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), along with two oth...
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Effective and targeted latency reversal in CD4+ T cells from individuals on long term combined antiretroviral therapy initiated during chronic HIV-1 infection Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-26 Minh Ha Ngo, Joshua Pankrac, Ryan C. Y. Ho, Emmanuel Ndashimye, Rahul Pawa, Renata Ceccacci, Tsigereda Biru, Abayomi S. Olabode, Katja Klein, Yue Li, Colin Kovacs, Robert Assad, Jeffrey M. Jacobson, David H. Canaday, Stephen Tomusange, Samiri Jamiru, Aggrey Anok, Taddeo Kityamuweesi, Paul Buule, Ronald M. Galiwango, Steven J. Reynolds, Thomas C. Quinn, Andrew D. Redd, Jessica L. Prodger, Jamie F. S
To date, an affordable, effective treatment for an HIV-1 cure remains only a concept with most “latency reversal” agents (LRAs) lacking specificity for the latent HIV-1 reservoir and failing in ear...
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Porcine low-density lipoprotein receptor plays an important role in classical swine fever virus infection Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-21 Elena Leveringhaus, Robin Poljakovic, Gina Herrmann, Gleyder Roman-Sosa, Paul Becher, Alexander Postel
Several cellular factors have been reported to be required for replication of classical swine fever virus (CSFV), a member of the genus Pestivirus within the family Flaviviridae. However, many step...
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Hepatitis E virus infects human testicular tissue and Sertoli cells Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-22 Tianxu Liu, Yalei Cao, Jiaming Weng, Songzhan Gao, Zirun Jin, Yun Zhang, Yuzhuo Yang, He Zhang, Changyou Xia, Xin Yin, Yong Luo, Qiyu He, Hui Jiang, Lin Wang, ZHe Zhang
Globally, hepatitis E virus (HEV) infections are prevalent. The finding of high viral loads and persistent viral shedding in ejaculate suggests that HEV replicates within the human male genital tra...
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Highly pathogenic avian influenza A(H5N1) virus of clade 2.3.4.4b isolated from a human case in Chile causes fatal disease and transmits between co-housed ferrets. Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-17 Joanna A. Pulit-Penaloza, Nicole Brock, Jessica A. Belser, Xiangjie Sun, Claudia Pappas, Troy J. Kieran, Poulami Basu Thakur, Hui Zeng, Dan Cui, Julia Frederick, Rodrigo Fasce, Terrence M. Tumpey, Taronna R Maines
Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses have caused large outbreaks within avian populations on five continents, with concurrent spillover into a variety of mammalian speci...
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Differential susceptibility of geographically distinct Ixodes ricinus populations to tick-borne encephalitis virus and louping ill virus Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-14 Julian W. Bakker, Helen J. Esser, Hein Sprong, Gert-Jan Godeke, Tabitha E. Hoornweg, Willem F. de Boer, Gorben P. Pijlman, Constantianus J. M. Koenraadt
Tick-borne encephalitis virus (TBEV) is an emerging pathogen in the Netherlands. Multiple divergent viral strains are circulating and the focal distribution of TBEV remains poorly understood. This ...
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The structure of inactivated mature tick-borne encephalitis virus at 3.0 Å resolution Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-11 Evgeny B. Pichkur, Mikhail F. Vorovitch, Alla L. Ivanova, Elena V. Protopopova, Valery B. Loktev, Dmitry I. Osolodkin, Aydar A. Ishmukhametov, Valeriya R. Samygina
Tick-borne encephalitis virus (TBEV) causes a severe disease, tick-borne encephalitis (TBE), that has a substantial epidemiological importance for Northern Eurasia. Between 10,000 and 15,000 TBE ca...
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Structural diversity of tick-borne encephalitis virus particles in the inactivated vaccine based on strain Sofjin Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-11 Andrey Moiseenko, Yichen Zhang, Mikhail F. Vorovitch, Alla L. Ivanova, Zheng Liu, Dmitry I. Osolodkin, Alexey M. Egorov, Aydar A. Ishmukhametov, Olga S. Sokolova
The main approach to preventing tick-borne encephalitis (TBE) is vaccination. Formaldehyde-inactivated TBE vaccines have a proven record of safety and efficiency but have never been characterized s...
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Comparison of morbidity and mortality after bloodstream infection with vancomycin-resistant versus -susceptible Enterococcus faecium: a nationwide cohort study in Denmark, 2010–2019 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-11 Peter Bager, Jonas Kähler, Mikael Andersson, Barbara Juliane Holzknecht, Sanne Grønvall Kjær Hansen, Kristian Schønning, Karen Leth Nielsen, Kristoffer Koch, Mette Pinholt, Marianne Voldstedlund, Anders Rhod Larsen, Brian Kristensen, Kåre Mølbak, Ute Wolff Sönksen, Sissel Skovgaard, Robert Skov, Anette M. Hammerum
The emergence of bloodstream infections (BSI) caused by vancomycin-resistant Enterococci (VRE) has caused concern. Nonetheless, it remains unclear whether these types are associated with an excess ...
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Tracing histoplasmosis genomic epidemiology and species occurrence across the USA Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-11 Bernardo Guerra Tenório, Daniel R. Kollath, Lalitha Gade, Anastasia P. Litvintseva, Tom Chiller, Jeff S. Jenness, Jason E. Stajich, Daniel R. Matute, Andrew S. Hanzlicek, Bridget M. Barker, Marcus de Melo Teixeira
Histoplasmosis is an endemic mycosis in North America frequently reported along the Ohio and Mississippi River Valleys, although autochthonous cases occur in non-endemic areas. In the United States...
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Genomic epidemiology and ceftazidime-avibactam high-level resistance mechanisms of Pseudomonas aeruginosa in China from 2010 to 2022 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-11 Xi Li, Longjie Zhou, Tailong Lei, Xiaofan Zhang, Jiayao Yao, Jintao He, Haiyang Liu, Heng Cai, Jingshu Ji, Yiwei Zhu, Yuexing Tu, Yunsong Yu, Hua Zhou
Ceftazidime-avibactam (CZA) resistance is a huge threat in the clinic; however, the underlying mechanism responsible for high-level CZA resistance in Pseudomonas aeruginosa (PA) isolates remains un...
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Surveillance of SARS-CoV-2 in wastewater by quantitative PCR and digital PCR: a case study in Shijiazhuang city, Hebei province, China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-11 Xiaoru Chai, Shiyou Liu, Chao Liu, Jiaxuan Bai, Juntao Meng, Hong Tian, Xu Han, Guangyue Han, Xiangdong Xu, Qi Li
In this study, we reported the first long-term monitoring of SARS-CoV-2 in wastewater in Mainland China from November 2021 to October 2023. The city of Shijiazhuang was employed for this case study...
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Spatio-temporal spread of Lassa virus and a new rodent host in the Mano River Union area, West Africa Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-06 Umaru Bangura, Christopher Davis, Joyce Lamin, James Bangura, Barré Soropogui, Andrew J. Davison, Jenna Nichols, Matej Vucak, Mickael Dawson, Rashid Ansumana, Dianah Sondufu, Dániel Cadar, Toni Rieger, Emma Thomson, Foday Sahr, N’Faly Magassouba, Bruno Ghersi, Brian H. Bird, Elisabeth Fichet-Calvet
The spread of Lassa virus (LASV) in Guinea, Liberia and Sierra Leone, which together are named the Mano River Union (MRU) area, was examined phylogeographically. To provide a reliable evolutionary ...
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Mosquitoes (Culicidae) as a vector of Encephalitozoon hellem (Microsporidia) Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-05 Artur Trzebny, Olena Nahimova, Natalia Volkova, Denys Hryhoriev, Anna Slodkowicz-Kowalska, Miroslawa Dabert
Published in Emerging Microbes & Infections (Vol. 13, No. 1, 2024)
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Genomic characters of Anaplasma bovis and genetic diversity in China Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-05 Xiao-Yu Han, Li-Feng Du, Zhe-Tao Lin, Cheng Li, Tao Xiong, Wen-Jie Zhu, Run-Ze Ye, Ning Wang, Yi-Fei Wang, Wan-Ying Gao, Lin Zhao, Xiao-Ming Cui, Wu-Chun Cao
The emergence of Anaplasma bovis or A. bovis-like infection in humans from China and the United States of America has raised concern about the public health importance of this pathogen. Although A....
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Evaluation of outbreak persistence caused by multidrug-resistant and echinocandin-resistant Candida parapsilosis using multidimensional experimental and epidemiological approaches Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-05 Farnaz Daneshnia, Daniel J. Floyd, Adam P. Ryan, Pegah Mosharaf Ghahfarokhy, Arefeh Ebadati, Sebastian Jusuf, Julieta Munoz, Nathan Elias Jeffries, Emma Elizabeth Yvanovich, Anna Apostolopoulou, Austin M. Perry, Cornelia Lass-Flörl, Asuman Birinci, Süleyha Hilmioğlu-Polat, Macit Ilkit, Geraldine Butler, Clarissa J. Nobile, Amir Arastehfar, Michael K. Mansour
Candida parapsilosis is known to cause severe and persistent outbreaks in clinical settings. Patients infected with multidrug-resistant C. parapsilosis (MDR Cp) isolates were identified in a large ...
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Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-03 Ehab A. Salama, Yehia Elgammal, Aruna Wijeratne, Nadia A. Lanman, Sagar M. Utturkar, Atena Farhangian, Jianing Li, Brigitte Meunier, Tony R. Hazbun, Mohamed N. Seleem
Candida auris has emerged as a problematic fungal pathogen associated with high morbidity and mortality. Amphotericin B (AmB) is the most effective antifungal used to treat invasive fungal candidia...
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Mycobacterium tuberculosis hijacks host macrophages-derived interleukin 16 to block phagolysosome maturation for enhancing intracellular growth Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-03 Haibo Su, Shufeng Weng, Liulin Luo, Qin Sun, Taiyue Lin, Huixia Ma, Yumo He, Jing Wu, Honghai Wang, Wenhong Zhang, Ying Xu
The discovery of promising cytokines and clarification of their immunological mechanisms in controlling the intracellular fate of Mycobacterium tuberculosis (Mtb) are necessary to identify effectiv...
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A screening study on the detection strain of Coxsackievirus A6: the key to evaluating neutralizing antibodies in vaccines Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-29 Fan Gao, Pei Liu, Yaqian Huo, Lianlian Bian, Xing Wu, Mingchen Liu, Qian Wang, Qian He, Fangyu Dong, Zejun Wang, Zhongping Xie, Zhongyang Zhang, Meirong Gu, Yingzhi Xu, Yajing Li, Rui Zhu, Tong Cheng, Tao Wang, Qunying Mao, Zhenglun Liang
The increasing incidence of diseases caused by Coxsackievirus A6 (CV-A6) and the presence of various mutants in the population present significant public health challenges. Given the concurrent dev...
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In vivo delivery of engineered synthetic DNA-encoded SARS-CoV-2 monoclonal antibodies for pre-exposure prophylaxis in non-human primates Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-28 Ami Patel, Kyle Rosenke, Elizabeth M. Parzych, Friederike Feldmann, Suman Bharti, Amanda J. Griffin, Blake Schouest, Matt Lewis, Jihae Choi, Neethu Chokkalingam, Viviane Machado, Brian J. Smith, Drew Frase, Ali R. Ali, Jamie Lovaglio, Brian Nguyen, Patrick W. Hanley, Susanne N. Walker, Ebony N. Gary, Abhijeet Kulkarni, Allison Generotti, Joseph R. Francica, Kim Rosenthal, Daniel W. Kulp, Mark T. Esser
COVID-19 remains a major public health concern. Monoclonal antibodies have received emergency use authorization (EUA) for pre-exposure prophylaxis against COVID-19 among high-risk groups for treatm...
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The safety, immunogenicity, and efficacy of heterologous boosting with a SARS-CoV-2 mRNA vaccine (SYS6006) in Chinese participants aged 18 years or more: a randomized, open-label, active-controlled phase 3 trial Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-29 Chunhua Zhou, Yuanzheng Qiu, Jianxin Wang, Xiang Zhong, Xiufang Zhu, Xiaojing Huang, Lan Yang, Qiaolei Ji, Feifei Zhou, Shunquan Wu, Mengjie Yang, Jing Zhang, Kaili Liu, Li Ji, Hanyu Yang, Chunlei Li, Yuanyuan Zhao
Continuous emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enhanced transmissibility, significant immune escape, and waning immunity call for booster vacc...
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AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-29 Jinxin Zheng, Xiaoju Liu, Yanpeng Xiong, Qingyin Meng, Peiyu Li, Fan Zhang, Xiaoming Liu, Zhiwei Lin, Qiwen Deng, Zewen Wen, Zhijian Yu
The rapid proliferation of multidrug-resistant (MDR) bacterial pathogens poses a serious threat to healthcare worldwide. Carbapenem-resistant (CR) Enterobacteriaceae, which have near-universal resi...
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H7N6 highly pathogenic avian influenza in Mozambique, 2023 Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-29 Iolanda Vieira Anahory Monjane, Hernâni Djedje, Esmeralda Tamele, Virgínia Nhabomba, Almiro Rogério Tivane, Zacarias Elias Massicame, Dercília Mudanisse Arone, Ambra Pastori, Alessio Bortolami, Isabella Monne, Timothy Woma, Charles E. Lamien, William G. Dundon
On 13 October 2023, the National Directorate for Livestock Development in Mozambique was notified of a suspected outbreak of avian influenza in commercial layers. Samples were screened by real-time...
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Correction Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-03-02
Published in Emerging Microbes & Infections (Vol. 13, No. 1, 2024)
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Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-29 Jing Lu, Shudan Tan, Hao Gu, Kunpeng Liu, Wei Huang, Zhaoli Yu, Guoliang Lu, Zihan Wu, Xiaobo Gao, Jinghua Zhao, Zongting Yao, Feng Yi, Yantao Yang, Hu Wang, Xue Hu, Mingqing Lu, Wei Li, Hui Zhou, Hang Yu, Chao Shan, Jinzhong Lin
Vaccines utilizing modified messenger RNA (mRNA) technology have shown robust protective efficacy against SARS-CoV-2 in humans. As the virus continues to evolve in both human and non-human hosts, r...
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RES-Xre toxin-antitoxin locus knaAT maintains the stability of the virulence plasmid in Klebsiella pneumoniae Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-23 Yongkui Chen, Ying-Xian Goh, Peifei Li, Jiahao Guan, Yanjie Chao, Hongping Qu, Hong-Yu Ou, Xiaoli Wang
Hypervirulent Klebsiella pneumoniae isolates have been increasingly reported worldwide, especially hypervirulent drug-resistant variants owing to the acquisition of a mobilizable virulence plasmid ...
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ESKAPE in China: epidemiology and characteristics of antibiotic resistance Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-23 Qixia Luo, Ping Lu, Yunbo Chen, Ping Shen, Beiwen Zheng, Jinru Ji, Chaoqun Ying, Zhiying Liu, Yonghong Xiao
The escalation of antibiotic resistance and the diminishing antimicrobial pipeline have emerged as significant threats to public health. The ESKAPE pathogens – Enterococcus faecium, Staphylococcus ...
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Identification of highly conserved Trypanosoma cruzi antigens for the development of a universal serological diagnostic assay Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-21 Alicia Majeau, Eric Dumonteil, Claudia Herrera
Chagas Disease is an important neglected tropical disease caused by Trypanosoma cruzi. There is no gold standard for diagnosis and commercial serological tests perform poorly in certain locations. ...
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Epidemiology and clinical features of Skin and Soft Tissue Infections Caused by PVL-Positive and PVL-Negative Methicillin-Resistant Staphylococcus aureus Isolates in inpatients in China: a single-center retrospective 7-year study Emerg. Microbes Infect. (IF 13.2) Pub Date : 2024-02-21 Ye Jin, Wangxiao Zhou, Qi Ge, Ping Shen, Yonghong Xiao
Previous studies have mainly focused on outpatient cases of skin and soft tissue infections (SSTIs), with limited attention to inpatient occurrences. Thus, we aimed to compare the clinical paramete...