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An extended low-density atmosphere around the Jupiter-sized planet WASP-193 b Nat. Astron. (IF 14.1) Pub Date : 2024-05-14 Khalid Barkaoui, Francisco J. Pozuelos, Coel Hellier, Barry Smalley, Louise D. Nielsen, Prajwal Niraula, Michaël Gillon, Julien de Wit, Simon Müller, Caroline Dorn, Ravit Helled, Emmanuel Jehin, Brice-Olivier Demory, Valerie Van Grootel, Abderahmane Soubkiou, Mourad Ghachoui, David. R. Anderson, Zouhair Benkhaldoun, Francois Bouchy, Artem Burdanov, Laetitia Delrez, Elsa Ducrot, Lionel Garcia, Abdelhadi
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Real-world plastic-waste success stories can help to boost global treaty Nature (IF 64.8) Pub Date : 2024-05-14
Letter to the Editor
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Interpersonal therapy can be an effective tool against the devastating effects of loneliness Nature (IF 64.8) Pub Date : 2024-05-14
Letter to the Editor
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Inequality is bad — but that doesn’t mean the rich are Nature (IF 64.8) Pub Date : 2024-05-14
Letter to the Editor
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Balls of lightning and flames from the sky: can science explain? Nature (IF 64.8) Pub Date : 2024-05-14
Snippets from Nature’s past.
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Standardized metadata for biological samples could unlock the potential of collections Nature (IF 64.8) Pub Date : 2024-05-14
Letter to the Editor
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Why mathematics is set to be revolutionized by AI Nature (IF 64.8) Pub Date : 2024-05-14
Cheap data and the absence of coincidences make maths an ideal testing ground for AI-assisted discovery — but only humans will be able to tell good conjectures from bad ones.
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How does ChatGPT ‘think’? Psychology and neuroscience crack open AI large language models Nature (IF 64.8) Pub Date : 2024-05-14
Researchers are striving to reverse-engineer artificial intelligence and scan the ‘brains’ of LLMs to see what they are doing, how and why.
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The phenomenon of genomic imprinting was discovered 40 years ago Nature (IF 64.8) Pub Date : 2024-05-14 Anne C. Ferguson-Smith, Marisa S. Bartolomei
Landmark 1984 experiments gave rise to a new epigenetics concept.
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How men evolved to care for babies — before society got in the way Nature (IF 64.8) Pub Date : 2024-05-14
An exploration of the evolution of male nurturing shows why, unlike fathers among other great apes, human dads are biologically wired to be hands-on parents.
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A DARPA-like agency could boost EU innovation — but cannot come at the expense of existing schemes Nature (IF 64.8) Pub Date : 2024-05-14
If Europe wants to create a high-risk, high-reward research body, it needs grass-roots backing.
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Mega study charts how genetic variants affect metabolism Nature (IF 64.8) Pub Date : 2024-05-14
The discovery of hundreds of genomic regions linked with metabolism promises to improve our understanding of metabolic diseases.
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Plasmid targeting and destruction by the DdmDE bacterial defence system Nature (IF 64.8) Pub Date : 2024-05-13 Jack P. K. Bravo, Delisa A. Ramos, Rodrigo Fregoso Ocampo, Caiden Ingram, David W. Taylor
While eukaryotic Argonautes play a pivotal role in post-transcriptional gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA degradation (1). Here, we elucidate the activation pathway of the DNA Defense Module DdmDE system, which rapidly eliminates small, multicopy plasmids from Vibrio cholerae
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Dazzling auroras are just a warm-up as more solar storms are likely, scientists say Nature (IF 64.8) Pub Date : 2024-05-13
Nature talks to physicists about what to expect in the next months and beyond as the Sun hits its 'maximum'.
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Brain-reading device is best yet at decoding ‘internal speech’ Nature (IF 64.8) Pub Date : 2024-05-13
Technology that enables researchers to interpret brain signals could one day allow people to talk using only their thoughts.
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Human embryos embrace asymmetry to form the body Nature (IF 64.8) Pub Date : 2024-05-13
The cells generated by the very first division of the fertilized egg make a lopsided contribution to the body’s organs and tissues.
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Daily briefing: Internet use seems to boost well-being Nature (IF 64.8) Pub Date : 2024-05-10
A survey of people in 168 countries finds that Internet use might boost life satisfaction and sense of purpose. Plus, what a Neanderthal’s Mona-Lisa smile tells us about ourselves and how the cauliflower got its whorls.
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Daily briefing: A millimetre of brain in spectacular detail Nature (IF 64.8) Pub Date : 2024-05-10
Google scientists have modelled a tiny fragment of the human brain at nanoscale resolution. Plus, a bold proposal to limit extreme wealth.
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Tackling debt, biodiversity loss, and climate change Science (IF 56.9) Pub Date : 2024-05-10 Elizabeth C. Losos, Alexander Pfaff, Stuart L. Pimm
At the United Nations climate conference in late 2023, multilateral development banks and environmental institutions committed to raising the number, size, types, and effectiveness of funding mechanisms that support developing countries to address the interconnected crises of debt, climate, and biodiversity. A “Task Force on Sustainability-Linked Sovereign Financing for Nature and Climate” will convene
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Low-temperature formation of pyridine and (iso)quinoline via neutral–neutral reactions Nat. Astron. (IF 14.1) Pub Date : 2024-05-13 Zhenghai Yang, Chao He, Shane J. Goettl, Alexander M. Mebel, Paulo F. G. Velloso, Márcio O. Alves, Breno R. L. Galvão, Jean-Christophe Loison, Kevin M. Hickson, Michel Dobrijevic, Xiaohu Li, Ralf I. Kaiser
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Why my heart beats for Nigeria’s endangered bats Nature (IF 64.8) Pub Date : 2024-05-13
Iroro Tanshi works to better understand a number of threatened species.
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Decent work for all: why multinationals need a helping hand Nature (IF 64.8) Pub Date : 2024-05-13
Moses Ngoze explains why the growth of micro, small and medium enterprises in Africa are key to achieving global economic growth.
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World’s brightest X-rays: China first in Asia to build next-generation synchrotron Nature (IF 64.8) Pub Date : 2024-05-13
The US$665-million High Energy Photon Source (HEPS) outside Beijing puts China among only a handful of countries that have fourth-generation synchrotron light sources.
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Is the Internet bad for you? Huge study reveals surprise effect on well-being Nature (IF 64.8) Pub Date : 2024-05-12
A survey of more than 2.4 million people finds that being online can have a positive effect on welfare.
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Daily briefing: ‘The ugly side of science’ — how to report negative results Nature (IF 64.8) Pub Date : 2024-05-09
Data repositories, workshops and alternative journals allow scientists to destigmatize and discuss negative results. Plus, a major step toward ultra-precise ‘nuclear’ clocks and the first rocky exoplanet with a confirmed atmosphere.
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These parrots go on killing sprees over real-estate shortages Nature (IF 64.8) Pub Date : 2024-05-10
Scientists recorded green-rumped parrotlets pecking others’ chicks to death, probably to claim the nest space.
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Diana Wall obituary: ecologist who foresaw the importance of soil biodiversity Nature (IF 64.8) Pub Date : 2024-05-10
Environmental scientist who revealed the crucial role of underground animals in sustainability.
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A jawless-fish genome untangles the history of vertebrate genome multiplications Nature (IF 64.8) Pub Date : 2024-05-10
Hagfish genetics shed light on how early vertebrates evolved.
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CRISPR therapy restores some vision to people with blindness Nature (IF 64.8) Pub Date : 2024-05-09
People with an inherited condition that causes vision loss in childhood had vision improvements after treatment to replace a mutated gene.
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The US Congress is taking on AI —this computer scientist is helping Nature (IF 64.8) Pub Date : 2024-05-09
Kiri Wagstaff, who temporarily shelved her academic career to provide advice on federal AI legislation, talks about life inside the halls of power.
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Cubic millimetre of brain mapped in spectacular detail Nature (IF 64.8) Pub Date : 2024-05-09
Google scientists have modelled a fragment of the human brain at nanoscale resolution, revealing cells with previously undiscovered features.
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US TikTok ban: how the looming restriction is affecting scientists on the app Nature (IF 64.8) Pub Date : 2024-05-09
Nature talks to researchers about what is at stake if users in the country lose access.
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How the cauliflower got its curlicues Nature (IF 64.8) Pub Date : 2024-05-08
More than 2,000 years of domestication have given the popular vegetable its short stem and clumpy ‘curds’.
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Directly imaging spin polarons in a kinetically frustrated Hubbard system Nature (IF 64.8) Pub Date : 2024-05-08 Max L. Prichard, Benjamin M. Spar, Ivan Morera, Eugene Demler, Zoe Z. Yan, Waseem S. Bakr
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The metal-poor atmosphere of a potential sub-Neptune progenitor Nat. Astron. (IF 14.1) Pub Date : 2024-05-09 Saugata Barat, Jean-Michel Désert, Allona Vazan, Robin Baeyens, Michael R. Line, Jonathan J. Fortney, Trevor J. David, John H. Livingston, Bob Jacobs, Vatsal Panwar, Hinna Shivkumar, Kamen O. Todorov, Lorenzo Pino, Georgia Mraz, Erik A. Petigura
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Characterization of the regimes of hydrodynamic escape from low-mass exoplanets Nat. Astron. (IF 14.1) Pub Date : 2024-05-09 J. H. Guo
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Rhizobia–diatom symbiosis fixes missing nitrogen in the ocean Nature (IF 64.8) Pub Date : 2024-05-09 Bernhard Tschitschko, Mertcan Esti, Miriam Philippi, Abiel T. Kidane, Sten Littmann, Katharina Kitzinger, Daan R. Speth, Shengjie Li, Alexandra Kraberg, Daniela Tienken, Hannah K. Marchant, Boran Kartal, Jana Milucka, Wiebke Mohr, Marcel M. M. Kuypers
Nitrogen (N2) fixation in oligotrophic surface waters is the main source of new nitrogen (N) to the ocean1 and plays a key role in fueling the biological carbon pump2. Oceanic N2 fixation is almost exclusively attributed to cyanobacteria, even though genes encoding nitrogenase, the enzyme fixing N2 into ammonia, are widespread among marine bacteria and archaea3-5. Little is known about these non-cyanobacterial
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How ignorance and gender inequality thwart treatment of a widespread illness Nature (IF 64.8) Pub Date : 2024-05-09
Tens of millions of people have female genital schistosomiasis, a neglected tropical disease that few physicians have even heard of. Efforts are under way to move it out of obscurity and empower women and girls to access sexual and reproductive health care.
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Structural mechanism of angiogenin activation by the ribosome Nature (IF 64.8) Pub Date : 2024-05-08 Anna B. Loveland, Cha San Koh, Robin Ganesan, Allan Jacobson, Andrei A. Korostelev
Angiogenin, an RNase A-family protein, promotes angiogenesis and has been implicated in cancer, neurodegenerative diseases, and epigenetic inheritance 1-10. Upon activation during cellular stress, angiogenin cleaves tRNAs at the anticodon loop, resulting in translation repression 11-15. The catalytic activity of isolated angiogenin, however, is very low, and the mechanisms of the enzyme activation
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A secondary atmosphere on the rocky Exoplanet 55 Cancri e Nature (IF 64.8) Pub Date : 2024-05-08 Renyu Hu, Aaron Bello-Arufe, Michael Zhang, Kimberly Paragas, Mantas Zilinskas, Christiaan van Buchem, Michael Bess, Jayshil Patel, Yuichi Ito, Mario Damiano, Markus Scheucher, Apurva V. Oza, Heather A. Knutson, Yamila Miguel, Diana Dragomir, Alexis Brandeker, Brice-Olivier Demory
Characterizing rocky exoplanets is a central endeavor of astronomy, and yet the search for atmospheres on rocky exoplanets has hitherto resulted in either tight upper limits on the atmospheric mass1–3 or inconclusive results4–6. The 1.95-REarth and 8.8-MEarth planet 55 Cnc e, with a predominantly rocky composition and an equilibrium temperature of ~2000 K, may have a volatile envelope (containing molecules
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Accurate structure prediction of biomolecular interactions with AlphaFold 3 Nature (IF 64.8) Pub Date : 2024-05-08 Josh Abramson, Jonas Adler, Jack Dunger, Richard Evans, Tim Green, Alexander Pritzel, Olaf Ronneberger, Lindsay Willmore, Andrew J. Ballard, Joshua Bambrick, Sebastian W. Bodenstein, David A. Evans, Chia-Chun Hung, Michael O’Neill, David Reiman, Kathryn Tunyasuvunakool, Zachary Wu, Akvilė Žemgulytė, Eirini Arvaniti, Charles Beattie, Ottavia Bertolli, Alex Bridgland, Alexey Cherepanov, Miles Congreve
The introduction of AlphaFold 21 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design2–6. In this paper, we describe our AlphaFold 3 model with a substantially updated diffusion-based architecture, which is capable of joint structure prediction of complexes including proteins, nucleic acids, small
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Elastic films of single-crystal two-dimensional covalent organic frameworks Nature (IF 64.8) Pub Date : 2024-05-08 Yonghang Yang, Baokun Liang, Jakob Kreie, Mike Hambsch, Zihao Liang, Cheng Wang, Senhe Huang, Xin Dong, Li Gong, Chaolun Liang, Dongyang Lou, Zhipeng Zhou, Jiaxing Lu, Yang Yang, Xiaodong Zhuang, Haoyuan Qi, Ute Kaiser, Stefan C. B. Mannsfeld, Wei Liu, Armin Gölzhäuser, Zhikun Zheng
The properties of polycrystalline materials are often dominated by defects, and two-dimensional (2D) crystals can even be divided and disrupted by a line defect1-3. In contrast, 2D crystals are often required to be processed into films, which are inevitably polycrystalline and contain numerous grain boundaries, and therefore are brittle and fragile, hindering application in flexible electronics, optoelectronics
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Alphafold 3.0: the AI protein predictor gets an upgrade Nature (IF 64.8) Pub Date : 2024-05-08
Hear the biggest stories from the world of science | 8 May 2024
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Mapping genotypes to chromatin accessibility profiles in single cells Nature (IF 64.8) Pub Date : 2024-05-08 Franco Izzo, Robert M. Myers, Saravanan Ganesan, Levan Mekerishvili, Sanjay Kottapalli, Tamara Prieto, Elliot O. Eton, Theo Botella, Andrew J. Dunbar, Robert L. Bowman, Jesus Sotelo, Catherine Potenski, Eleni P. Mimitou, Maximilian Stahl, Sebastian El Ghaity-Beckley, JoAnn Arandela, Ramya Raviram, Daniel C. Choi, Ronald Hoffman, Ronan Chaligné, Omar Abdel-Wahab, Peter Smibert, Irene M. Ghobrial, Joseph
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Observation of Nagaoka polarons in a Fermi–Hubbard quantum simulator Nature (IF 64.8) Pub Date : 2024-05-08 Martin Lebrat, Muqing Xu, Lev Haldar Kendrick, Anant Kale, Youqi Gang, Pranav Seetharaman, Ivan Morera, Ehsan Khatami, Eugene Demler, Markus Greiner
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Full-colour 3D holographic augmented-reality displays with metasurface waveguides Nature (IF 64.8) Pub Date : 2024-05-08 Manu Gopakumar, Gun-Yeal Lee, Suyeon Choi, Brian Chao, Yifan Peng, Jonghyun Kim, Gordon Wetzstein
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The refinery of the future Nature (IF 64.8) Pub Date : 2024-05-08 Eelco T. C. Vogt, Bert M. Weckhuysen
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All-optical subcycle microscopy on atomic length scales Nature (IF 64.8) Pub Date : 2024-05-08 T. Siday, J. Hayes, F. Schiegl, F. Sandner, P. Menden, V. Bergbauer, M. Zizlsperger, S. Nerreter, S. Lingl, J. Repp, J. Wilhelm, M. A. Huber, Y. A. Gerasimenko, R. Huber
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The intrinsic substrate specificity of the human tyrosine kinome Nature (IF 64.8) Pub Date : 2024-05-08 Tomer M. Yaron-Barir, Brian A. Joughin, Emily M. Huntsman, Alexander Kerelsky, Daniel M. Cizin, Benjamin M. Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M. Orozco, Christina Schoenherr, Cari Sagum, Mark T. Bedford, R. Max Wynn, Shih-Chia Tso, David T. Chuang, Lei Li, Shawn S.-C. Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean
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Chemical short-range disorder in lithium oxide cathodes Nature (IF 64.8) Pub Date : 2024-05-08 Qidi Wang, Zhenpeng Yao, Jianlin Wang, Hao Guo, Chao Li, Dong Zhou, Xuedong Bai, Hong Li, Baohua Li, Marnix Wagemaker, Chenglong Zhao
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Boron catalysis in a designer enzyme Nature (IF 64.8) Pub Date : 2024-05-08 Lars Longwitz, Reuben B. Leveson-Gower, Henriëtte J. Rozeboom, Andy-Mark W. H. Thunnissen, Gerard Roelfes
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Genome organization around nuclear speckles drives mRNA splicing efficiency Nature (IF 64.8) Pub Date : 2024-05-08 Prashant Bhat, Amy Chow, Benjamin Emert, Olivia Ettlin, Sofia A. Quinodoz, Mackenzie Strehle, Yodai Takei, Alex Burr, Isabel N. Goronzy, Allen W. Chen, Wesley Huang, Jose Lorenzo M. Ferrer, Elizabeth Soehalim, Say-Tar Goh, Tara Chari, Delaney K. Sullivan, Mario R. Blanco, Mitchell Guttman
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Ligand cross-feeding resolves bacterial vitamin B12 auxotrophies Nature (IF 64.8) Pub Date : 2024-05-08 Gerrit Wienhausen, Cristina Moraru, Stefan Bruns, Den Quoc Tran, Sabiha Sultana, Heinz Wilkes, Leon Dlugosch, Farooq Azam, Meinhard Simon
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Structural pharmacology and therapeutic potential of 5-methoxytryptamines Nature (IF 64.8) Pub Date : 2024-05-08 Audrey L. Warren, David Lankri, Michael J. Cunningham, Inis C. Serrano, Lyonna F. Parise, Andrew C. Kruegel, Priscilla Duggan, Gregory Zilberg, Michael J. Capper, Vaclav Havel, Scott J. Russo, Dalibor Sames, Daniel Wacker
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An atomic boson sampler Nature (IF 64.8) Pub Date : 2024-05-08 Aaron W. Young, Shawn Geller, William J. Eckner, Nathan Schine, Scott Glancy, Emanuel Knill, Adam M. Kaufman
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Self-oscillating polymeric refrigerator with high energy efficiency Nature (IF 64.8) Pub Date : 2024-05-08 Donglin Han, Yingjing Zhang, Cenling Huang, Shanyu Zheng, Dongyuan Wu, Qiang Li, Feihong Du, Hongxiao Duan, Weilin Chen, Junye Shi, Jiangping Chen, Gang Liu, Xin Chen, Xiaoshi Qian
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Targetable leukaemia dependency on noncanonical PI3Kγ signalling Nature (IF 64.8) Pub Date : 2024-05-08 Qingyu Luo, Evangeline G. Raulston, Miguel A. Prado, Xiaowei Wu, Kira Gritsman, Karley S. Whalen, Kezhi Yan, Christopher A. G. Booth, Ran Xu, Peter van Galen, John G. Doench, Shai Shimony, Henry W. Long, Donna S. Neuberg, Joao A. Paulo, Andrew A. Lane
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Dozens of Brazilian universities hit by strikes over academic wages Nature (IF 64.8) Pub Date : 2024-05-08
Some professors and staff members have been on strike for as long as four weeks as they seek better conditions at their institutions.
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Quantum tunnelling of electrons brings ultrafast optical microscopy to the atomic scale Nature (IF 64.8) Pub Date : 2024-05-08
A signal from tunnelling electrons enables the development of an optical microscope that works on extremely short spatio-temporal scales.
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Physicists move closer to an ultra-precise ‘nuclear’ clock Nature (IF 64.8) Pub Date : 2024-05-08
Timekeepers based on energy shifts in atomic nuclei could transform fundamental-physics research.