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Extracellular cleavage of microglia-derived progranulin promotes diet-induced obesity Diabetes (IF 6.2) Pub Date : 2024-09-20 Chae Beom Park, Chan Hee Lee, Kae Won Cho, Sunghun Shin, Won Hee Jang, Junyeong Byeon, Yu Rim Oh, Sung Jun Kim, Jae Woo Park, Gil Myoung Kang, Se Hee Min, Seyun Kim, Rina Yu, Min-Seon Kim
Hypothalamic innate immune responses to dietary fats underpin the pathogenesis of obesity, in which microglia play a critical role. Progranulin (PGRN) is an evolutionarily -conserved secretory protein containing seven-and-a-half granulin (GRN) motifs. It is cleaved into GRNs by multiple proteases. In the central nervous system, PGRN is highly expressed in microglia. To investigate the role of microglia-derived
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Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People with Obesity and Type 2 Diabetes Diabetes (IF 6.2) Pub Date : 2024-09-12 Max C. Petersen, Mihoko Yoshino, Gordon I. Smith, Rafael C. Gaspar, Mario Kahn, Dmitri Samovski, Gerald I. Shulman, Samuel Klein
Muscle sn-1,2-diacylglycerol (DAG) and C18:0 ceramide accumulation in sarcolemmal and mitochondrial compartments have been proposed to regulate muscle insulin sensitivity. Here, we evaluated whether weight loss-induced improvements in insulin sensitivity were associated with changes in muscle sn-1,2-DAG and ceramide content in people with obesity and type 2 diabetes. We measured skeletal muscle insulin
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A Single Dose of Phosphoinositide-3-kinase Inhibitor Alpelisib Induces Insulin Resistance in Healthy Adults: A Randomized Feasibility Study Diabetes (IF 6.2) Pub Date : 2024-09-12 Joshua R. Cook, Nur Bedeir, Zachary D. Sone, Julia Wattacheril, Henry N. Ginsberg, Blandine Laferrère
Our objective is to test a single dose of the phosphoinositide-3-kinase (PI3K) inhibitor alpelisib as a tool for acute modeling of insulin resistance in healthy volunteers. This single-center, double-blind, phase 1 clinical trial randomized healthy adults to take a single oral dose of alpelisib 300 mg (n = 5) or placebo (n = 6) at bedtime, followed by measurement of glucose, insulin, and C-peptide
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CRTC1 in Mc4r-expressing cells is required for peripheral metabolism and systemic energy homeostasis Diabetes (IF 6.2) Pub Date : 2024-09-12 Haruka Miyamori, Takumi Yokokawa, Motoki Miyakita, Kazuki Ozaki, Tsuyoshi Goto, Kazuo Inoue, Shigenobu Matsumura
Melanocortin-4-receptor (Mc4r) is a G protein-coupled receptor (GPCR) that controls systemic energy balance by regulating food intake and energy expenditure. Although the detailed molecular mechanism remains unclear, the activation of cAMP signaling in Mc4r-expressing cells reportedly suppresses food intake and increases energy expenditure. cAMP-responsive element-binding protein-regulated transcriptional
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Erratum. 189-OR: Food Insecurity and Inability to Obtain Recommended Medications, Diabetes Technology, and Multidisciplinary Services in Youth and Young Adults with Diabetes. Diabetes 2024;73 (Suppl. 1):189-OR Diabetes (IF 6.2) Pub Date : 2024-08-29 Angela D. Liese, Emmanuel F. Julceus, Caroline Rudisill, Faisal Malik, Kate Flory, Edward A. Frongillo, Katherine A. Sauder, Jason A. Mendoza
In the abstract cited above, author Nadine El Kalach was inadvertently omitted from the author list. The full, correct author list is as follows: Nadine El Kalach, Emmanuel F. Julceus, Caroline Rudisill, Faisal Malik, Kate Flory, Edward A. Frongillo, Katherine A. Sauder, Jason A. Mendoza, and Angela D. Liese. All authors approve the addition and the order of the revised author list. The authors apologize
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Glucagon Stimulation Test and Insulin Secretory Capacity in Clinical Assessment of Incretin-Based Therapy for Diabetes Diabetes (IF 6.2) Pub Date : 2024-08-28 Takuya Haraguchi, Yuji Yamazaki, Hitoshi Kuwata, Ryota Usui, Yoshiyuki Hamamoto, Yutaka Seino, Daisuke Yabe, Yuichiro Yamada
Evaluation of insulin secretory capacity is essential to understand the pathophysiological condition of individuals with diabetes and to assess the efficacy of drugs used in treatment of the disease. The 1 mg intravenous glucagon stimulation test (GST) is widely used to evaluate residual β cell function; we previously reported that GST assessment of insulin secretory capacity is useful in assessing
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Visceral adipocyte-derived extracellular vesicle miR-27a-5p elicits glucose intolerance by inhibiting pancreatic β-cell insulin secretion Diabetes (IF 6.2) Pub Date : 2024-08-26 Yaqin Zhang, Bin Qian, Yang Yang, Fandi Niu, Changsong Lin, Honglei Yuan, Jianan Wang, Tijun Wu, Yixue Shao, Shulin Shao, Aiming Liu, Jingwen Wu, Peng Sun, Xiaoai Chang, Yan Bi, Wei Tang, Yunxia Zhu, Fang Chen, Dongming Su, Xiao Han
Pancreatic β-cell dysfunction caused by obesity can be associated with alterations in the levels of microRNAs (miRNAs). However, the role of miRNAs in such processes remains elusive. Here, we show that pancreatic islet miR-27a-5p, which is markedly increased in obese mice and impairs insulin secretion, is mainly delivered by visceral adipocyte-derived extracellular vesicles (EVs). Depleting miR-27a-5p
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Müller cells harboring exosomal lncRNA OGRU modulates microglia polarization in diabetic retinopathy via serving as miRNA sponges Diabetes (IF 6.2) Pub Date : 2024-08-23 ShuHua Fu, WenJing Sun, Lu Liu, JiPing Xiao, Jian Xiong, YaoYun Hu, QianQian Zhou, XiaoLong Yin
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus which is associated with visual loss and blindness worldwide. However, the effective treatments for both early- and late-stage DR remains lacking. A streptozotocin (STZ)-induced diabetic mice model and high glucose (HG)-treated Müller cell model were established. M1/M2 microglia polarization was assessed by immunofluorescence
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Leptin activation of dorsal raphe neurons inhibits feeding behavior Diabetes (IF 6.2) Pub Date : 2024-08-22 Nicholas David Maxwell, Cora Elizabeth Smiley, Alia Tereza Sadek, Frances Zoe Loyo-Rosado, Daniel Christian Giles, Victoria Alice Macht, Jennifer Lynn Woodruff, Donzelle Lee Taylor, Victoria Marie Glass, Steven Peter Wilson, Lawrence Patrick Reagan, James Robert Fadel, Claudia Alejandra Grillo
Leptin is a homeostatic regulatory element that signals the presence of adipocyte energy stores, reduces food intake, and increases energy expenditure. Similarly, serotonin (5- HT), a signaling molecule found in both the central and peripheral nervous systems, also controls food intake. Using neuronal tract-tracing, pharmacological and optogenetics approaches, and in vivo microdialysis, combined with
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Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop Diabetes (IF 6.2) Pub Date : 2024-08-22 Carla J. Greenbaum, Gerald T. Nepom, Lauren K. Wood-Heickman, Diane K. Wherrett, Linda A. DiMeglio, Kevan C. Herold, Jeffrey P. Krischer
The approval of teplizumab to delay the onset of type 1 diabetes is an important inflection point in the decades long pursuit to treat the cause of the disease rather than its symptoms. NIDDK convened a workshop of the Diabetes Mellitus Interagency Coordinating Committee titled “Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes” to review this accomplishment and identify
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The effect of metformin on peripheral nerve morphology in type 2 diabetes: a cross-sectional observational study Diabetes (IF 6.2) Pub Date : 2024-08-21 Roshan Dhanapalaratnama, Tushar Issar, Leiao Leon Wang, Darren Tran, Ann M. Poynten, Kerry-Lee Milner, Natalie CG. Kwai, Arun V. Krishnan
Diabetic peripheral neuropathy (DPN) affects around 50% of the 500 million people with type 2 diabetes worldwide and is considered disabling and irreversible. The present study was undertaken to assess the effect of metformin on peripheral neuropathy outcomes in type 2 diabetes. 69 type 2 diabetes participants receiving metformin were recruited and underwent clinical assessment, peripheral nerve ultrasound
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Pancreatic β cell TRAPδ deficiency reduces insulin production but improves insulin sensitivity Diabetes (IF 6.2) Pub Date : 2024-08-21 Jiyun Guo, Yanshu Yang, Ning Xu, Xin Li, Ying Yang, Wenli Feng, Yuanyuan Ye, Xiaoxi Xu, Jingqiu Cui, Ming Liu, Yumeng Huang
The translocon-associated protein-δ (TRAPδ) plays a role in insulin biosynthesis within pancreatic β cells. However, its pathophysiological significance in maintaining islet β cell function and glucose homeostasis remains unclear. In this study, we generated a mouse model featuring pancreatic β cell-specific deletion of TRAPδ (TRAPδ βKO). Our findings revealed that TRAPδ βKO resulted in decreased circulating
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Role of Peptidyl arginine deiminase 4-dependent macrophage extracellular traps formation on Type 1 Diabetes pathogenesis Diabetes (IF 6.2) Pub Date : 2024-08-13 Yiming Shen, Ruiya Shi, ShiPing Lu, Yan Wang, Ziqi Zhou, Chenhua Wu, Qi You, Hongye Fan, Jie Wu
Excessive macrophage extracellular traps (METs) formation has been implicated in several autoimmune disease pathogenesis; however, its impact on Type 1 Diabetes (T1D) and related mechanisms remains enigmatic. Here, we demonstrated the pivotal role of peptidyl arginine deiminase 4 (PAD4) in driving profuse METs formation and macrophage M1 polarization in intestinal inflammation of non-obese diabetic
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PNLIPRP1 hypermethylation in exocrine pancreas links type 2 diabetes and cholesterol metabolism Diabetes (IF 6.2) Pub Date : 2024-08-13 Lucas Maurin, Lorella Marselli, Mathilde Boissel, Lijiao Ning, Raphael Boutry, Justine Fernandes, Mara Suleiman, Carmela De Luca, Audrey Leloire, Vincent Pascat, Bénédicte Toussaint, Souhila Amanzougarene, Mehdi Derhourhi, Anne Jörns, Sigurd Lenzen, François Pattou, Julie Kerr-Conte, Mickaël Canouil, Piero Marchetti, Amélie Bonnefond, Philippe Froguel, Amna Khamis
We postulated that T2D predisposes to exocrine pancreatic diseases through (epi)genetic mechanisms. We explored the methylome (methylationEPIC arrays) of the exocrine pancreas of 141 donors, assessing the impact of T2D. Epigenome-wide association study (EWAS) for T2D identified a hypermethylation in an enhancer of the Pancreatic-Lipase-Related-Protein 1 (PNLIPRP1) gene, associated with decreased PNLIPRP1
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PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy Diabetes (IF 6.2) Pub Date : 2024-08-13 Xinyi Chen, Andrea Ruiz-Velasco, Zhiyong Zou, Susanne S Hille, Claire Ross, Oveena Fonseka, Sanskruti R Gare, Nasser hawimel o Alatawi, Rida Raja, Jiayan Zhang, Namrita Kaur, Xiangjun Zhao, Henrietta Morrell-Davies, Jessica M Miller, Riham R.E Abouleisa, Qinghui Ou, Derk Frank, Martin K Rutter, Christian Pinali, Tao Wang, Tamer M.A Mohamed, Oliver J Müller, Wei Liu
Obesity-induced lipid overload in cardiomyocytes contributes to profound oxidative stress and cardiomyopathy, culminating in heart failure. In this study, we investigate a novel mechanism whereby lipids accumulate in cardiomyocytes and seek the relevant treatment strategies. P21-activated kinase 3 (PAK3) was elevated in obese human myocardium, and the murine hearts and cardiomyocytes upon diet- or
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The association between low sex hormone binding globulin and increased risk of type 2 diabetes is mediated by increased visceral and liver fat: results from observational and Mendelian randomization analyses Diabetes (IF 6.2) Pub Date : 2024-08-06 Theresa A. Stangl, Chantal M. Wiepjes, Roelof A.J. Smit, Astrid van Hylckama Vlieg, Hildo. J. Lamb, Jeroen H.P.M. van der Velde, Esther Winters van Eekelen, Sebastiaan C. Boone, Martijn C.G.J. Brouwers, Frits R. Rosendaal, Martin den Heijer, Annemieke C. Heijboer, Renée de Mutsert
The aim of this study was to investigate the associations between sex hormone binding globulin (SHBG), visceral fat (VAT), liver fat content, and risk of type 2 diabetes. In the Netherlands Epidemiology of Obesity study 5690 women (53%) and men without pre-existing diabetes were included and followed for incident type 2 diabetes. SHBG concentrations were measured in all, VAT with MRI, and liver fat
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Revisiting the pattern of loss of β-cell function in preclinical Type 1 Diabetes. Diabetes (IF 6.2) Pub Date : 2024-08-06 Mariangela Martino, Alfonso Galderisi, Carmella Evans-Molina, Colin Dayan
Type 1 diabetes (T1D) results from beta cell destruction due to autoimmunity. It has been proposed that beta cell loss is relatively quiescent in the early years after seroconversion to islet antibody positivity (stage 1) with accelerated beta cell loss only developing around 6-18 months prior to clinical diagnosis. This construct implies that immunointervention in this early stage will be of little
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No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data Diabetes (IF 6.2) Pub Date : 2024-07-31 Elisabetta Manduchi, Héléne C. Descamps, Jonathan Schug, Tong Da, Deeksha Lahori, Hilana El-Mekkoussi, Michael R. Betts, Klaus H. Kaestner
Persistent enterovirus B infection has been proposed as an important contributor to the etiology of type 1 diabetes. We leveraged extensive bulk RNA-sequencing data from alpha, beta, and exocrine cells, as well as single cell islet RNA-Seq data from the Human Pancreas Analysis Program (HPAP), to evaluate the presence of enterovirus B sequences in the pancreas of type 1 diabetic and pre-diabetic (non-diabetic
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Cryopreservation of stem cell-derived beta-like cells enriches for insulin-producing cells with improved function Diabetes (IF 6.2) Pub Date : 2024-07-31 Jessie M. Barra, Austin T. Kratz, Roberto Castro-Gutierrez, James Proia, Gurprit Bhardwaj, Ed Phelps, Holger A. Russ
The generation of stem cell-derived beta-like cells (sBC) holds extreme promise as not only an abundant insulin-producing cell source for replacement therapy of Type 1 diabetes (T1D), but also as an invaluable model system for investigating human beta cell development, immunogenicity, and function. Several groups have developed methodology to direct differentiate human pluripotent stem cells into pancreatic
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The miR-203/ZBTB20/MAFA axis orchestrates pancreatic β-cell maturation and identity during weaning and diabetes Diabetes (IF 6.2) Pub Date : 2024-07-26 Yating Li, Yuqian Yang, Yi Sun, Lu He, Lin Zhao, Haoran Sun, Xiaoai Chang, Rui Liang, Shusen Wang, Xiao Han, Yunxia Zhu
Maturation of postnatal β cells is regulated in a cell-autonomous manner, and metabolically stressed β cells regress to an immature state, ensuring defective β-cell function and the onset of type 2 diabetes. The molecular mechanisms connecting the nutritional transition to β-cell maturation remain largely unknown. Here, we report a miR-203/ZBTB20/MAFA regulatory axis that mediates the β-cell maturation
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No evidence for persistent enteroviral B infection of pancreatic islets in type 1 diabetic and pre-diabetic patients from RNA-Seq data Diabetes (IF 6.2) Pub Date : 2024-07-26 Elisabetta Manduchi, Héléne C. Descamps, Jonathan Schug, Tong Da, Deeksha Lahori, Hilana El-Mekkoussi, Michael R. Betts, Klaus H. Kaestner
Persistent enterovirus B infection has been proposed as an important contributor to the etiology of type 1 diabetes. We leveraged extensive bulk RNA-sequencing data from alpha, beta, and exocrine cells, as well as single cell islet RNA-Seq data from the Human Pancreas Analysis Program (HPAP), to evaluate the presence of enterovirus B sequences in the pancreas of type 1 diabetic and pre-diabetic (non-diabetic
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Metabolic stress levels influence the ability of the myelin transcription factors to regulate β-cell identity and survival Diabetes (IF 6.2) Pub Date : 2024-07-26 Xin Tong, Mahircan Yagan, Ruiying Hu, Simone Nevills, Teri D. Stevenson, Roland W. Stein, Appakalai N. Balamurugan, Guoqiang Gu
A hallmark of type 2 diabetes (T2D) is endocrine islet β-cell failure, which can occur via cell dysfunction, loss-of-identity, and/or death. How each is induced remains largely unknown. Here, we use mouse β-cells that are deficient for Myelin transcription factors (Myt TFs, including Myt1, 2, and 3) to address this question. We have reported that inactivating all three Myt genes in pancreatic progenitor
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Cryopreservation of stem cell-derived beta-like cells enriches for insulin-producing cells with improved function Diabetes (IF 6.2) Pub Date : 2024-07-26 Jessie M. Barra, Austin T. Kratz, Roberto Castro-Gutierrez, James Proia, Gurprit Bhardwaj, Ed Phelps, Holger A. Russ
The generation of stem cell-derived beta-like cells (sBC) holds extreme promise as not only an abundant insulin-producing cell source for replacement therapy of Type 1 diabetes (T1D), but also as an invaluable model system for investigating human beta cell development, immunogenicity, and function. Several groups have developed methodology to direct differentiate human pluripotent stem cells into pancreatic
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Glucagon Clearance is Decreased in Chronic Kidney Disease, but Preserved in Liver Cirrhosis Diabetes (IF 6.2) Pub Date : 2024-07-25 Magnus F. G. Grøndahl, Andreas H. Lange, Malte P. Suppli, Jonatan I. Bagger, Mira Thing, Lise L. Gluud, Dea H. Kofod, Mads Hornum, Gerrit Van Hall, Samuel A.J. Trammell, Trisha J. Grevengoed, Bolette Hartmann, Jens J. Holst, Tina Vilsbøll, Mikkel B. Christensen, Asger B. Lund, Filip K. Knop
It is not completely clear which organs are responsible for glucagon elimination in humans, and disturbances in the elimination of glucagon could contribute to the hyperglucagonemia observed in chronic liver disease and chronic kidney disease (CKD). Here, we evaluated kinetics and metabolic effects of exogenous glucagon in individuals with stage 4 CKD (n =16), individuals with Child-Pugh A-C cirrhosis
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A three-week ketogenic diet increases skeletal muscle insulin sensitivity in individuals with obesity – a randomized, controlled crossover trial Diabetes (IF 6.2) Pub Date : 2024-07-25 Thien Vinh Luong, Mette Glavind Bülow Pedersen, Caroline Bruun Abild, Katrine Meyer Lauritsen, Mette Louise Gram Kjærulff, Niels Møller, Lars Christian Gormsen, Esben Søndergaard
A ketogenic diet (KD) can induce weight loss and improve glycemic regulation, potentially reducing the risk of developing type 2 diabetes. To elucidate the underlying mechanisms behind these beneficial effects of a KD, we investigated the impact of a KD on organ-specific insulin sensitivity (IS) in skeletal muscle, liver, and adipose tissue. We hypothesized that a KD would increase IS in skeletal muscle
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GAS6 and AXL promote insulin resistance by rewiring insulin signaling and increasing insulin receptor trafficking to endosomes Diabetes (IF 6.2) Pub Date : 2024-07-24 Céline Schott, Amélie Germain, Julie Lacombe, Monica Pata, Denis Faubert, Jonathan Boulais, Peter Carmeliet, Jean-François Côté, Mathieu Ferron
Growth-arrest specific 6 (GAS6) is a secreted protein that acts as a ligand for TAM receptors (TYRO3, AXL and MERTK). In humans, GAS6 circulating levels and genetic variations in GAS6 are associated with hyperglycemia and increased risk of type 2 diabetes. However, the mechanisms by which GAS6 influences glucose metabolism are not understood. Here, we show that Gas6 deficiency in mice increases insulin
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Identification of BAF60b as a chromatin remodeling checkpoint of diet-induced fatty liver disease Diabetes (IF 6.2) Pub Date : 2024-07-24 Jing Zhong, Xiuyu Ji, Yali Zhao, Yihe Jia, Churui Song, Jinghuan Lv, Yuying Chen, Yanping Zhou, Xue Lv, Zhuoyin Yang, Zheyu Zhang, Qiyao Xu, Weihong Wang, Haiyan Chen, Aoyuan Cui, Yu Li, Zhuo-Xian Meng
Overnutrition has gradually become the primary causative factor of nonalcoholic fatty liver disease (NAFLD). However, how nutritional signals are integrated to orchestrate the transcriptional programs important for NAFLD progression remains poorly understood. Here, we identified hepatic BAF60b as a lipid-sensitive subunit of the switch/sucrose-nonfermentable (SWI/SNF) chromatin-remodeling complex and
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1113-P: Utilizing a Novel Telemedicine Clinic for Managing Type 2 Diabetes—A Six-Month Pilot Study Diabetes (IF 6.2) Pub Date : 2024-07-19 FIORELLA SOTOMAYOR, CHIKARA GOTHONG, REYNIER HERNANDEZ, MONICA Y. CHOE, GARRETT I. ASH, WILLIAM H. SCOTT, LILLIAN PINAULT, FERNANDO GOMEZ-PERALTA, LAKSHMI G. SINGH, JOHN D. SORKIN, ILIAS (ELIAS) SPANAKIS
Introduction & Objective: RCT aimed to assess if a Diabetes Advanced Telemedicine (DAT) clinic leads to improvement in glycemic control compared to standard of care (SoC). Methods: Patients with type 2 diabetes (T2D) randomized to DAT or SoC. DAT used continuous glucose monitoring devices, smart insulin pens, telecommunication (i.e. video visits) with physical activity (PA) counseling by an exercise
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344-OR: The MOTS-c/CK2 Pathway Is a Novel Molecular Target for Type 2 Diabetes in East Asians Diabetes (IF 6.2) Pub Date : 2024-07-19 HIROSHI KUMAGAI, SU JEONG KIM, BRENDAN MILLER, SHIN HYUNG LEE, HIROFUMI ZEMPO, TOSHIHARU NATSUME, JUNXIANG WAN, RICARDO RAMIREZ, HEMAL H. MEHTA, YUICHIRO NISHIDA, NORIYUKI FUKU, SHOHEI DOBASHI, ERI MIYAMOTO-MIKAMI, HISASHI NAITO, MEGUMI HARA, CHIHARU IWASAKA, YOSUKE YAMADA, YASUKI HIGAKI, KEITARO TANAKA, KELVIN YEN, PINCHAS COHEN
Introduction & Objective: MOTS-c is a mitochondrial DNA-encoded microprotein that improves impaired glucose metabolism caused by aging and high fat diet. The presence of a naturally occurring genetic variant of MOTS-c, K14Q MOTS-c, increases the susceptibility to type 2 diabetes (T2D) in East Asians. Nevertheless, the precise mechanism of MOTS-c action has not been fully elucidated. Here, we demonstrate
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1970-LB: A Sugary Recipe for Adverse Outcomes? Third Trimester HbA1c and Composite Obstetric and Perinatal Adverse Outcomes, a Prospective Study Diabetes (IF 6.2) Pub Date : 2024-07-19 JESSICA HAO-CHEN WU, MARA ULIN, SAMREEN HASSAN, CAMILLE MAI-PHUONG TRAN QUANG, ANUSHA KARRI, DANNIE SIEBEN, FERNANDA ALVARADO, VICTORIA GERALDO, KAMLESH K. JHA, JESSICA C. BISHOP-ROYSE, EDWARD C. LAMPLEY
Objective: to evaluate the association between elevated HbA1c levels close to delivery and the increased risks of composite obstetric and perinatal adverse outcomes. Method: women with singleton pregnancies, at 34 weeks or above admitted for delivery were invited. HbA1c levels were obtained during the admission. The composite obstetrics and perinatal adverse outcomes were collected and analyzed. Results:
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1092-P: Effectiveness of a Hybrid Care Model for Type 2 Diabetes —A Three-Month Evaluation Diabetes (IF 6.2) Pub Date : 2024-07-19 IHSAN ALMARZOOQI, HALA ZAKARIA, MILENA CACCELLI, CIGDEM OZKAN, JESTONI BANGAYAN, MIRABELLE C. DANDAN, DIANNE JANE DIVINO, SOFIA ALEABOVA, YOUSEF SAID, ALI HASHEMI
Continuous monitoring in diabetes care enhances access, convenience, adherence, and glycemic control. Challenges in digital-only solutions include trust-building and limitations in face-to-face interactions, along with the lack of engagement by care teams outside the clinic setting. A hybrid model where providers incorporate both remote data monitoring and engagement with in-person visits would address
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1924-LB: Clinical Performance of a Novel CGM System Diabetes (IF 6.2) Pub Date : 2024-07-19 JULIA K. MADER, GUIDO FRECKMANN, THOMAS FORST, GERHARD VOGT, MICHAEL ANGSTMANN, SANDRA MOCERI, DANIEL MILITZ
Introduction and Objective: The use of continuous glucose monitoring (CGM) improves glycemic control in people with diabetes (PwD). The availability of multiple systems with high accuracy allows PwD and their health care professionals to choose the best option for each individual based on respective needs. This study aimed to evaluate the clinical performance of a novel CGM system, the Accu-Chek® SmartGuide
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349-OR: Reduction of RNA-Editing Enzyme ADAR1 in Human Islets Triggers an Interferon Response and Impairs Beta-Cell Function Diabetes (IF 6.2) Pub Date : 2024-07-19 CHUNHUA DAI, AJAY K. SINGH, REBEKAH BRANTLEY, AMBER BRADLEY, REGINA JENKINS, DIANE C. SAUNDERS, MARCELA BRISSOVA, EREZ LEVANON, AGNES KLOCHENDLER, YUVAL DOR, ALVIN C. POWERS
Introduction & Objective: It is thought that viral infection triggers islet inflammation, an interferon signature, and autoimmunity resulting in type 1 diabetes. Despite extensive research, an inciting virus has not been identified. We hypothesized that impaired RNA editing and accumulation of double-stranded RNA in beta cells triggers an interferon response, causing islet inflammation, autoimmunity
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336-OR: Females Undergoing Islet Transplantation with CNI-Based Immunosuppression May Be at Higher Risk of Renal Function Decline Diabetes (IF 6.2) Pub Date : 2024-07-19 ALICE L.J. CARR, BRAULIO A. MARFIL-GARZA, ANNA LAM, BLAIRE L. ANDERSON, DOUG O'GORMAN, TATSUYA KIN, DAVID BIGAM, A.M. JAMES SHAPIRO, PETER A. SENIOR
Islet transplantation (ITx) is an established treatment for recurrent, severe hypoglycemia in type 1 diabetes, however, requires lifelong immunosuppression (IS) which can be nephrotoxic. We conducted a risk regression to identify factors associated with progression to Stage 3 CKD (S3CKD) or worse post-ITx. We used data from adults undergoing ITx alone at the University of Alberta Hospital between March
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350-OR: Parturition Event Regulates Endocrine Genesis during Pancreas Differentiation Diabetes (IF 6.2) Pub Date : 2024-07-19 AGENA SUZUKI, TOMOMI TAGUCHI, SHIORI ITO, HIDEAKI SHIMOTATARA, KAORI KIMURA, NAOYA SHIMIZU, REI FUJISHIMA, MIWA HIMURO, TAKESHI MIYATSUKA
It is essential to decipher developmental features of each endocrine cell, which leads to exploring efficient methods for generating surrogate β cells. We previously developed three reporter mouse lines to quantify the genesis of endocrine progenitor cells, β cells, and α cells. Flow cytometry analysis revealed a significant decrease in the number of newly-generated endocrine progenitors and β cells
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1020-P: Evolution over Time of the Discrepancy between HbA1c and Glucose Management Indicator—Findings from a Franco-Belgian Cohort of 347 Patients Diabetes (IF 6.2) Pub Date : 2024-07-19 JEAN-PIERRE RIVELINE, GAETAN PREVOST, ANAIS ANDRIEU, MICHAEL JOUBERT, PHILIPPE ORIOT, ALFRED PENFORNIS, JEAN-CHRISTOPHE PHILIPS, JEAN-BAPTISTE JULLA, EMMANUEL COSSON
A discrepancy between laboratory-measured HbA1c and Glucose Management Indicator (GMI), estimated from continuous glucose monitoring, is frequently encountered in clinical practice. However, its evolution over time is not yet known. Methodology: We conducted a multicenter retrospective study (9 centers) that collected pairs of HbA1c and GMI (calculated over 90 days) at T0, T1 year, T2 years of follow-up
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1563-P: High Fat and Fructose Feeding Severely Impairs Hepatic Glucose Effectiveness but Not Insulin Action Under Euglycemic Conditions Diabetes (IF 6.2) Pub Date : 2024-07-19 DALE S. EDGERTON, GUILLAUME KRAFT, HANNAH L. WATERMAN, BEN FARMER, KALISHA YANKEY, MARTA S. SMITH, JON R. HASTINGS, MELANIE SCOTT, ALAN D. CHERRINGTON
Diets high in fat and fructose (HFHF) disrupt glucose metabolism. This study compared the effects of a HFHF diet on liver insulin action vs glucose effectiveness. Dogs were fed either a chow or HFHF diet for 1 month. At the start of each study, 3-3H-glucose was infused and after a basal sampling period, somatostatin and basal glucagon were given. During the experimental period (4h) either insulin was
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138-OR: Pioglitazone Amplifies the Decrease in HbA1c and Prevents the Increase in Plasma Ketone Caused by Dapagliflozin in Type 1 Diabetes Mellitus Patients Diabetes (IF 6.2) Pub Date : 2024-07-19 MUHAMMAD ABDUL-GHANI, GOZDE BASKOY, AFIF NAKHLEH, SIHAM ABDELGANI, FAHD AL-MULLA, MOHAMED ABU-FARHA, FAHAD ALAJMI, THAMER ALESSA, RALPH A. DEFRONZO, NAIM SHEHADEH
Introduction and Objectives: SGLT2 inhibitors (SGLT2i) lower the plasma glucose concentration in T1DM patients. However, they cause an increase in plasma ketone concentration and risk of ketoacidosis. The aim of the present study is to examine whether pioglitazone amplifies the decrease in HbA1c and prevents the increase in plasma ketone concentration caused by dapagliflozin in T1DM patients. Methods:
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1308-P: A Voice-Based AI Algorithm Can Predict Type 2 Diabetes Status—Findings from the Colive Voice Study on U.S. Adult Participants Diabetes (IF 6.2) Pub Date : 2024-07-19 ABIR ELBEJI, MÉGANE PIZZIMENTI, GLORIA A. AGUAYO, AURELIE FISCHER, HANIN AYADI, FRANCK MAUVAIS-JARVIS, JEAN-PIERRE RIVELINE, VLADIMIR DESPOTOVIC, GUY FAGHERAZZI
Introduction: Reducing undiagnosed type 2 diabetes (T2D) cases worldwide is an urgent public health challenge. Most current screening methods are invasive, lab-based, and costly. Meanwhile, there is a growing focus on noninvasive T2D detection through advanced artificial intelligence (AI) and digital technology. This study explores the feasibility of using a voice-based AI algorithm to predict T2D
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332-OR: Multiomic Profiling of Extended Honeymoon Unveils New Therapeutic Targets Diabetes (IF 6.2) Pub Date : 2024-07-19 CRISTIAN LORETELLI, AHMED GOUDA ABDELRAHMAN ABDELSALAM, MOUFIDA BEN NASR, VERA USUELLI, EMMA ASSI, MONICA ZOCCHI, ADRIANA PETRAZZUOLO, AGNESE PETITTI, GIUSEPPE CANNALIRE, FRANCESCA D'ADDIO, CHIARA MAMELI, PAOLO FIORINA
Introduction & Objective: Approximately 50% of patients with new-onset Type 1 Diabetes (T1D) experience a temporary recovery in pancreatic β-cell function, termed the "honeymoon" (HM) phase, lasting approximately 7-9 months on average, and only rarely extending to years. This phase provides a crucial window for interventions to preserve insulin secretion, yet the factors contributing to its occurrence
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1004-P: Remote Initiation of Continuous Glucose Monitoring in Older Adults Using Insulin Diabetes (IF 6.2) Pub Date : 2024-07-19 CATHERINE MAHONEY, CHRISTINE SLYNE, MEDHA MUNSHI, COLIN D. CONERY, HALEY BRABANT, NOA KRAKOFF, JANE D. BULGER, RUTH S. WEINSTOCK, ELENA TOSCHI
Background & Objective: Initiation of continuous glucose monitoring (CGM) remotely in adults with diabetes (DM) has been shown beneficial. However, this model has not been evaluated in older adults. The objective of this study was to assess the benefit and challenges encountered by older patients on multiple daily insulin injections (MDI) initiating CGM using a virtual platform. Methods: Older adults
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1304-P: MODY Calculator Overestimates MODY Probability in Multiethnic Cohort with Youth-Onset Type 2 Diabetes Phenotype Diabetes (IF 6.2) Pub Date : 2024-07-19 RAYMOND J. KREIENKAMP, BEVERLEY SHIELDS, TONI I. POLLIN, MUSTAFA TOSUR, AMY S. SHAH, ANGELA D. LIESE, CATHERINE PIHOKER, SHYLAJA SRINIVASAN, ANDREW T. HATTERSLEY, MIRIAM UDLER, MARIA J. REDONDO
Introduction & Objective: Identifying monogenic diabetes (MODY) remains a challenge for clinicians. Shields and colleagues developed a widely used MODY probability calculator (https://www.diabetesgenes.org/) based on clinical measures to assist in this decision. Because the calculator was developed in a predominantly adult White European population without any pediatric T2D cases, we sought to test
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1245-P: GDM Patients and Prognostic Factors for Subsequent Type 2 Diabetes Mellitus—An Electronic Cohort Review Diabetes (IF 6.2) Pub Date : 2024-07-19 RYUNG S. KIM, LIHUA LI, CARMEN R. ISASI, ATHENA PHILIS-TSIMIKAS, JEE-YOUNG MOON, JUNXIU LIU, DIANA S. WOLFE, CAROL J. LEVY
Introduction: GDM affects 8-10% of pregnancies in the US and nearly 50% of these women have subsequent diabetes diagnosis. However, research on the prognostic factors of T2D incidence among women with GDM is scarce, due to the limited sample sizes. We aim 1) to construct a large electronic cohort of GDM and 2) to build a prognostic model for T2D incidence among patients with GDM. Methods: We extracted
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229-OR: Orforglipron Improves Markers of Beta-Cell Function and Insulin Sensitivity in Type 2 Diabetes Diabetes (IF 6.2) Pub Date : 2024-07-19 JULIO ROSENSTOCK, DEBORAH A. ROBINS, KEVIN L. DUFFIN, JONATHAN M. WILSON, KIEREN J. MATHER, HIYA BANERJEE, YANZHU LIN, SARAH EYDE, CHRISTOF M. KAZDA, MANIGE KONIG
Orforglipron (OFG), an oral, non-peptide GLP-1 receptor agonist, demonstrated significantly greater glycemic control and weight loss at doses ≥12 mg vs placebo (PBO) or dulaglutide (DU) 1.5 mg in a 26-week phase 2 study of adults with type 2 diabetes (T2D) (Table). These exploratory analyses investigated mechanisms by which OFG improved glycemic control in T2D by analyzing exploratory biomarkers. Participants
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348-OR: Multiancestry Whole Genome Sequencing (WGS) Meta-analysis to Identify Loci Associated with Imaging-Measured Hepatic Steatosis Diabetes (IF 6.2) Pub Date : 2024-07-19 NICHOLETTE ALLRED, CHINMAY RAUT, YANHUA CHEN, ANTONINO OLIVERI, JEFFREY O'CONNELL, KATHLEEN RYAN, JEROME I. ROTTER, STEPHEN S. RICH, AARON HAKIM, PATRICIA PEYSER, LAWRENCE F. BIELAK, CHING-TI LIU, JAMES G. TERRY, MYRIAM FORNAGE, LYNNE E. WAGENKNECHT, ELIZABETH K. SPELIOTES, NHLBI TRANS-OMICS FOR PRECISION MEDICINE (TOPMED)PROGRAM, GOLD CONSORTIUM
Introduction and Objective: Steatotic liver disease, formerly called non-alcoholic fatty liver disease (NAFLD), is the most common cause of chronic liver disease worldwide; yet, few effective methods for prevention/treatment exist making it one of the biggest unmet public health needs of our time. To date, genetic studies have been limited to identifying common variants in predominantly European-ancestry
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345-OR: Beyond Size Matters—The Impact of Pancreatic Volume and Pancreatic Fat on Type 2 Diabetes Diabetes (IF 6.2) Pub Date : 2024-07-19 HAJIME YAMAZAKI, SHIN-ICHI TAUCHI, MITSURU DOHKE, NAGISA HANAWA, YOSHIHISA KODAMA, AKIO KATANUMA, SHUNICHI FUKUHARA, KATSIARYNA PRYSTUPA, JULIA HUMMEL, ROBERT WAGNER, MARTIN HENI
Introduction & Objective: Individuals with type 2 diabetes (T2D) are thought to have a smaller pancreas; however, whether this is cause or consequence of T2D is unclear. We investigated the association between pancreas volume and T2D risk and whether this association was modified by pancreatic fat. Methods: Using magnetic resonance imaging from the UK Biobank, 25,389 individuals were classified into
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23-PUB: Reduction of Residual Lipid Risk in Patients with Type 2 Diabetes and Mixed Dyslipidemia Treated with a Fixed-Dose Combination of Atorvastatin/Fenofibrate Diabetes (IF 6.2) Pub Date : 2024-07-19 JOSE G. SANDER-PADILLA, LAURA A. LUGO-SÁNCHEZ, KEVIN F. RIOS-BRITO, KARLA E. RODRIGUEZ-ROCANDIO, MARÍA M. ARGUEDAS, DIANA FLORES-HUANOSTA, ILEANA C. RODRIGUEZ-VAZQUEZ, JORGE GONZALEZ-CANUDAS, YULIA ROMERO
Introduction and Objective: The persistence of a high cardiovascular risk not dependent on LDL-C levels constitutes the residual cardiovascular risk of lipid origin (RLR). Lipid-lowering treatment does not always consider the modification of RLR. The present study aimed to evaluate the changes in RRL profile in patients with T2D and dyslipidemia treated with a fixed-dose combination (FDC) of Atorvastatin/Fenofibrate
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1301-P: Frequency of Single Autoantibody Positivity (SAB+) Varies by Race/Ethnicity and Area Deprivation Index in Individuals at Risk for Type 1 Diabetes (T1D) Diabetes (IF 6.2) Pub Date : 2024-07-19 ANANTA ADDALA, SUSANNE M. CABRERA, DAVID D. CUTHBERTSON, INGRID LIBMAN, MUSTAFA TOSUR, ALEJANDRO F. SILLER, LINDA A. DIMEGLIO, KEVAN C. HEROLD, MARIA J. REDONDO, HEBA M. ISMAIL
Introduction & Objective: The diversity of individuals living with T1D has increased, driven by Hispanic (H) and non-Hispanic Black (NHB) populations. Yet, whether H and NHB populations have different rates of SAB+ than other groups, which can impact clinical care and research opportunities, has not been well characterized. Area deprivation and race/ethnicity are strongly associated with each other
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333-OR: Hypoimmune Islet Cells Mediate Insulin Independence after Allogeneic Transplantation in a Fully Immunocompetent Nonhuman Primate without Immunosuppression Diabetes (IF 6.2) Pub Date : 2024-07-19 XIAOMENG HU, KATHY WHITE, CHI YOUNG, ARI G. OLROYD, PAUL KIEVIT, ANDREW CONNOLLY, TOBIAS DEUSE, SONJA SCHREPFER
Treatment of type 1 diabetes mellitus (T1DM) via allogeneic donor transplant has limited success due to morbidities from immunosuppression (IS) and a gradual loss of engrafted pancreatic islet function. We report that allogeneic transplantation of engineered, primary, hypoimmune, pseudo-islets (HIP p-islets) engraft into a fully immunocompetent, diabetic non-human primate (NHP), provide stable endocrine
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346-OR: Hypothalamic Gliosis Is Associated with CVD Risk Factors in the Framingham Heart Study (FHS) Diabetes (IF 6.2) Pub Date : 2024-07-19 JUSTIN LO, SUSAN J. MELHORN, KELSEY OLERICH, ALYSSA HUANG, SARAH KEE, ALEXA BEISER, SUDHA SESHADRI, CHARLES DECARLI, ELLEN SCHUR
Introduction: Hypothalamic gliosis is linked to obesity and insulin resistance in rodent models and humans. We tested associations between a radiologic measure of hypothalamic gliosis and clinically relevant cardiovascular disease (CVD) risk factors, as well as prevalent coronary heart disease (CHD). Methods: Using brain MRI images from FHS participants (n=867), T2 signal intensities were extracted
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1073-P: Trends in Guideline-Directed Medication Therapy for Type 2 Diabetes in a Statewide Quality Collaborative between 2018–2023 Diabetes (IF 6.2) Pub Date : 2024-07-19 KARA R. MIZOKAMI-STOUT, LAUREN OSHMAN, HEIDI L. DIEZ, DINA H. GRIAUZDE, JOYCE M. LEE, KATHERINE L. KHOSROVANEH, NEHA BHOMIA, NOA KIM, JACQUELINE RAU, JACOB REISS, RODICA BUSUI
Introduction and Objective: Since 2021, the Michigan Collaborative for Type 2 Diabetes (MCT2D) aims to improve guideline-directed medication therapies (GDMT) for type 2 diabetes (T2D). We examined trends in glucagon-like peptide-1 receptor agonist (GLP-1RA) and sodium-glucose transport protein 2 inhibitor (SGLT2i) prescribing rates comparing primary care (PC) and endocrinology (Endo) practices enrolled
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240-OR: Longitudinal Assessment of Glycemia and Severe Hypoglycemia among Adults with Type 1 Diabetes—An Online Survey Diabetes (IF 6.2) Pub Date : 2024-07-19 JENNIFER L. SHERR, KAITLIN HAGAN, RACHEL BHAK, MEGAN PETER, HUYEN NGUYEN, CHENKUN WANG, TATHABBAI PAKALAPATI, JORDAN SHERWOOD, TINA GUPTA, JASON L. GAGLIA, EMILEE M. CORNELIUS, KATHERINE S.M. CHAPMAN, WENDY WOLF, JEREMY PETTUS
Introduction & Objective: Longitudinal trends of glycemia and severe hypoglycemic events (SHE) among individuals with T1D are not well described, particularly in those using diabetes technologies (i.e., continuous glucose monitors [CGM], automated insulin delivery [AID]). Methods: An online survey recruited adults with T1D through the T1D Exchange Registry or online communities from February-April
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1971-LB: Contributions of Fasting and Postprandial Glucose Increments to Overall Hyperglycemia in Pregnant Women with Type 1 Diabetes Diabetes (IF 6.2) Pub Date : 2024-07-19 PING LING, DAIZHI YANG, CHAOFAN WANG, XUEYING ZHENG, SIHUI LUO, XUBIN YANG, HONGRONG DENG, WEN XU, JINHUA YAN, JIANPING WENG
Aims: To evaluate the relative contribution of fasting hyperglycemia (FHG) and postprandial hyperglycemia (PHG) to overall hyperglycemia across time in range (TIR) and glycated hemoglobin (HbA1c) categories in pregnant women with type 1 diabetes mellitus (T1DM). Materials and Methods: This observational study included 112 pregnant women with T1DM from the CARNATION study who wore continuous glucose
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192-OR: Effect of Video Conferences between Endocrinologists and Family Doctors on Levels of Recommended Medication among Persons with Type 2 Diabetes—Pragmatic RCT Diabetes (IF 6.2) Pub Date : 2024-07-19 THIM PRÆTORIUS, ANNE SOFIE B. LUNDBERG, ESKILD K. FREDSLUND, NIKLAS B. ROSSEN, SØREN GREGERSEN, ANDERS PRIOR, ESBEN SØNDERGAARD, SOREN T. KNUDSEN, ANNELLI SANDBÆK
Introduction and objective: To close treatment gaps in type 2 diabetes (T2D), a 2023 US National Clinical Care Commission calls for testing models of virtual collaboration. We examined the effect of video conferences between endocrinologists and family doctors on levels of recommended medication among persons with T2D seen in family practice. Methods: Two arm, pragmatic RCT with 25 family practices
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1388-P: Risk of Diabetes among Children and Young Adults after COVID-19 Infection—The DiCAYA Study Diabetes (IF 6.2) Pub Date : 2024-07-19 SARAH CONDERINO, H. LESTER KIRCHNER, LORNA THORPE, JASMIN DIVERS, ANNEMARIE G. HIRSCH, CARA M. NORDBERG, BRIAN S. SCHWARTZ, BO CAI, CAROLINE RUDISILL, JIHAD S. OBEID, ANGELA D. LIESE, BRIAN E. DIXON, DANA DABELEA, ANNA BELLATORRE, HUI SHAO, JIANG BIAN, YI GUO, KRISTI REYNOLDS, MATTHEW T. MEFFORD, MANMOHAN K. KAMBOJ, ENEIDA A. MENDONCA, KATIE ALLEN, SHAWNA BURGETT, EVA LUSTIGOVA, SARAH BOST, MITCH MALTENFORT
Introduction & Objective: The association between COVID-19 infection and incident diabetes remains unclear despite recent research. Using a multistate electronic health record-based surveillance approach, we examined the risk of new diabetes among children (<18) and young adults (18-44) post COVID-19 infection. Methods: Pooled fixed-effects meta-analyses were performed. Patients (n=5,412,604) with
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1928-LB: Feasibility of Calibration-Free Intradermal Glucose Monitoring Using a Sensor Microarray Diabetes (IF 6.2) Pub Date : 2024-07-19 MARK P. CHRISTIANSEN, NARESH C. BHAVARAJU, REBECCA GOTTLIEB, ALAN CAMPBELL, SIRILAK SATTAYASAMITSATHIT, MARK C. BRISTER, KEITH NOGUEIRA, AMY L. VANDENBERG, RICH YANG, JARED R. TANGNEY
Introduction: Subcutaneous glucose sensors using introducer needles have been well characterized. Robust microsensors are required for a less invasive approach, accessing interstitial glucose in the dermis. Advancements in semiconductor manufacturing have facilitated new sensing technologies using arrays of silicon microsensors on a wearable patch without introducer needles. Several independent electrodes
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104-OR: State-Dependent Activity in Hindbrain Glucagon-Like Peptide 1—Producing Neurons Regulates Consummatory and Valence Behavior through Functionally Interconnected Hypothalamic and Limbic Circuits Diabetes (IF 6.2) Pub Date : 2024-07-19 MIGUEL DURAN, SONJA VIRKUS, KYLIE A. MCMICHEN, YASLLE ANDRADE CAVALCANTE MORAES, ESHITA YADAV, JAGJOT K. SINGH, ZOE FOKAKIS, SAMANTHA Q. STOCKING, SAMUEL O. POOLE, CHAD S. HUNTER, KIRK M. HABEGGER, JAMES A. HARDAWAY
Introduction: Glucagon-like peptide 1 (GLP-1) therapeutics have experienced a meteoric rise in adoption, but our understanding of the endogenous systems that produce GLP-1 and how they regulate behavior remain incomplete. Preproglucagon neurons in the nucleus of the solitary tract (GcgNTS neurons) are the primary source of GLP-1 in the brain. In this study, we examined the neurophysiological and causal
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197-OR: Algorithmic Identification May Improve Racial and Ethnic Diversity of Clinical Study Recruitment Diabetes (IF 6.2) Pub Date : 2024-07-19 SARA JANE CROMER, VICTORIA CHEN, MICAH KOSS, MELTON M. FAN, CRISTINA I. FERNÁNDEZ HERNÁNDEZ, WILLIAM G. MARSHALL, EVELYN GREAUX, MIRIAM UDLER
Introduction: Early analyses of Rare and Atypical Diabetes Network (RADIANT) study recruitment suggested that goals to recruit underrepresented groups were not being met. We tested whether a validated electronic health record (EHR) algorithm to identify people with an atypical form of diabetes improved identification of racially and ethnically minoritized individuals who may be candidates for the RADIANT
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1927-LB: Impact of Continuous Glucose Monitoring Use on Hospitalizations in People with Type 2 Diabetes—Real-World Analysis Diabetes (IF 6.2) Pub Date : 2024-07-19 SATISH K. GARG, IRL B. HIRSCH, ENRICO REPETTO, JANET K. SNELL-BERGEON, BRIAN ULMER, CHRISTOPHER PERKINS, RICHARD M. BERGENSTAL
Introduction & Objective: The increasing prevalence of diabetes in the US continues to drive a steady rise in healthcare resource utilization. The real-world impact of continuous glucose monitoring (CGM) on hospitalizations in a broad type 2 diabetes population is not completely understood. Methods: In this retrospective analysis, we used Optum's de-identified Market Clarity data of >79 million people
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1559-P: Heterogeneity of Trajectories of Metabolic Parameters after 50% Beta-Cell Mass Loss by Pancreatectomy Diabetes (IF 6.2) Pub Date : 2024-07-19 ROBERTO BIZZOTTO, GIANFRANCO DI GIUSEPPE, LAURA SOLDOVIERI, FRANCESCA CINTI, SIMONA MOFFA, MICHELA BRUNETTI, GEA CICCARELLI, SERGIO ALFIERI, GIUSEPPE QUERO, ANDREA MARI, ANDREA GIACCARI, TERESA MEZZA
Temporal trajectories of metabolic parameters in the onset of dysglycemia are heterogeneous. We aimed to characterize the temporal trajectories of metabolic parameters after β cell mass reduction by pancreatectomy and to study their heterogeneity. Individuals without known diabetes diagnosis (N = 83) underwent mixed-meal/oral glucose tolerance tests (MMTT/OGTT) and/or hyperglycemic/euglycemic clamp