Targeted tissue ablation involving the anterior hippocampus is the standard of care for patients with drug-resistant mesial temporal lobe epilepsy. However, a substantial proportion continues to suffer from seizures even after surgery. We identified the fasciola cinereum (FC) neurons of the posterior hippocampal tail as an important seizure node in both mice and humans with epilepsy. Genetically defined FC neurons were highly active during spontaneous seizures in epileptic mice, and closed-loop optogenetic inhibition of these neurons potently reduced seizure duration. Furthermore, we specifically targeted and found the prominent involvement of FC during seizures in a cohort of six patients with epilepsy. In particular, targeted lesioning of the FC in a patient reduced the seizure burden present after ablation of anterior mesial temporal structures. Thus, the FC may be a promising interventional target in epilepsy.

涉及海马前区的靶向组织消融是耐药内侧颞叶癫痫患者的标准治疗方法。然而，相当一部分人即使在手术后仍继续遭受癫痫发作。我们发现海马后尾部的灰片膜 (FC) 神经元是癫痫小鼠和人类的重要癫痫节点。遗传定义的 FC 神经元在癫痫小鼠自发癫痫发作期间高度活跃，这些神经元的闭环光遗传学抑制可有效缩短癫痫发作持续时间。此外，我们专门针对并发现了 6 名癫痫患者的队列中 FC 在癫痫发作期间的显着参与。特别是，对患者 FC 进行靶向损伤可减轻前内侧颞结构消融后出现的癫痫发作负担。因此，FC可能是癫痫有希望的介入靶点。