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Pyroptosis in health and disease: mechanisms, regulation and clinical perspective. Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-20 Yifan Liu,Renjie Pan,Yuzhen Ouyang,Wangning Gu,Tengfei Xiao,Hongmin Yang,Ling Tang,Hui Wang,Bo Xiang,Pan Chen
Pyroptosis is a type of programmed cell death characterized by cell swelling and osmotic lysis, resulting in cytomembrane rupture and release of immunostimulatory components, which play a role in several pathological processes. Significant cellular responses to various stimuli involve the formation of inflammasomes, maturation of inflammatory caspases, and caspase-mediated cleavage of gasdermin. The
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Neutrophil extracellular traps in homeostasis and disease. Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-20 Han Wang,Susan J Kim,Yu Lei,Shuhui Wang,Hui Wang,Hai Huang,Hongji Zhang,Allan Tsung
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement
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An algorithm for the diagnosis and management of IgE-mediated food allergy, 2024 update. Allergy (IF 12.6) Pub Date : 2024-09-20 Alexandra F Santos,Carmen Riggioni,George Du Toit,Isabel Skypala
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Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-19 Jiujie Cui, Shukui Qin, Yuhong Zhou, Shuang Zhang, Xiaofeng Sun, Mingjun Zhang, Jiuwei Cui, Weijia Fang, Kangsheng Gu, Zhihua Li, Jufeng Wang, Xiaobing Chen, Jun Yao, Jun Zhou, Gang Wang, Yuxian Bai, Juxiang Xiao, Wensheng Qiu, Bangmao Wang, Tao Xia, Chunyue Wang, Li Kong, Jiajun Yin, Tao Zhang, Xionghu Shen, Deliang Fu, Chuntao Gao, Huan Wang, Quanren Wang, Liwei Wang
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The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-19 Qiaonan Shan, Lu Yin, Qifan Zhan, Jiongjie Yu, Sheng Pan, Jianyong Zhuo, Wei Zhou, Jiaqi Bao, Lincheng Zhang, Jiachen Hong, Jianan Xiang, Qingyang Que, Kangchen Chen, Shengjun Xu, Jingrui Wang, Yangbo Zhu, Bin He, Jingbang Wu, Haiyang Xie, Shusen Zheng, Tingting Feng, Sunbin Ling, Xiao Xu
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Zero shot health trajectory prediction using transformer npj Digit. Med. (IF 12.4) Pub Date : 2024-09-19 Pawel Renc, Yugang Jia, Anthony E. Samir, Jaroslaw Was, Quanzheng Li, David W. Bates, Arkadiusz Sitek
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Regulatory responses and approval status of artificial intelligence medical devices with a focus on China npj Digit. Med. (IF 12.4) Pub Date : 2024-09-18 Yuehua Liu, Wenjin Yu, Tharam Dillon
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Glucagon-like peptide-1 receptor: mechanisms and advances in therapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-18 Zhikai Zheng, Yao Zong, Yiyang Ma, Yucheng Tian, Yidan Pang, Changqing Zhang, Junjie Gao
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Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2 Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-18 Miao Zhu, Fang Huang, Huize Sun, Kunpeng Liu, Zhen Chen, Baocheng Yu, Haojie Hao, Haizhou Liu, Shuang Ding, Xueyan Zhang, Lishi Liu, Kui Zhang, Jierao Ren, Yi Liu, Haibin Liu, Chao Shan, Wuxiang Guan
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Exploring recent advances in drugs severe cutaneous adverse reactions immunopathology. Allergy (IF 12.6) Pub Date : 2024-09-18 Romane Cadot,Perrine Gery,Vanina Lenief,Jean-François Nicolas,Marc Vocanson,Marie Tauber
Severe cutaneous adverse reactions to drugs (SCARs) are rare but life-threatening delayed allergies. While they primarily affect the skin, they can also affect internal organs. Accordingly, they present with diverse clinical symptoms that vary not only between SCARs subtypes but also among patients. Despite the availability of topical and systemic treatments, these only address the symptoms and not
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HLA‐DR+ regulatory T cells and IL‐10 are associated with success or failure of desensitization outcomes Allergy (IF 12.6) Pub Date : 2024-09-18 Xiaoying Zhou, Diane Dunham, Sayantani B. Sindher, Andrew Long, Andrea Fernandes, Iris Chang, Amal Assa'ad, Jacqueline Pongracic, Jonathan M. Spergel, Jonathan Tam, Stephen Tilles, Julie Wang, Scott D. Boyd, R. Sharon Chinthrajah, Kari C. Nadeau
BackgroundOmalizumab (XOLAIR®)‐assisted multi‐food oral immunotherapy (mOIT) has been shown to safely, effectively, and rapidly desensitize patients with multiple food allergies. In our clinical trial (NCT02626611) on omalizumab‐assisted mOIT, different desensitization outcomes (success or failure of desensitization) were observed following a period of either continued or discontinued mOIT. However
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A drug mix and dose decision algorithm for individualized type 2 diabetes management npj Digit. Med. (IF 12.4) Pub Date : 2024-09-17 Mila Nambiar, Yong Mong Bee, Yu En Chan, Ivan Ho Mien, Feri Guretno, David Carmody, Phong Ching Lee, Sing Yi Chia, Nur Nasyitah Mohamed Salim, Pavitra Krishnaswamy
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A systematic review and meta analysis on digital mental health interventions in inpatient settings npj Digit. Med. (IF 12.4) Pub Date : 2024-09-17 Alexander Diel, Isabel Carolin Schröter, Anna-Lena Frewer, Christoph Jansen, Anita Robitzsch, Gertraud Gradl-Dietsch, Martin Teufel, Alexander Bäuerle
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How might Hospital at Home enable a greener and healthier future? npj Digit. Med. (IF 12.4) Pub Date : 2024-09-16 Dylan Powell, Fanny Burrows, Geraint Lewis, Stephen Gilbert
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Recurrent Pulmonary Veno-Occlusive Disease after Lung Transplantation. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-17 Esther J Nossent,Gregorius D Nossent,Lilian J Meijboom,Erik A M Verschuuren,Chistiaan T Gan,Jurjan Aman,Harm Jan Bogaard,Teodora Radonic,Peter Dorfmüller,Anton Vonk Noordegraaf
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Lung Protective Mechanical Ventilation in Severe Acute Brain Injured Patients: A Multicenter, Randomized Clinical Trial (PROLABI). Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-17 Luciana Mascia,Vito Fanelli,Alice Mistretta,Matteo Filippini,Mattia Zanin,Maurizio Berardino,Anna Teresa Mazzeo,Anselmo Caricato,Massimo Antonelli,Francesco Della Corte,Francesca Grossi,Marina Munari,Massimiliano Caravello,Francesco Alessandri,Irene Cavalli,Mario Mezzapesa,Lucia Silvestri,Marilena Casartelli Liviero,Paolo Zanatta,Paolo Pelosi,Giuseppe Citerio,Claudia Filippini,Paola Rucci,Frank A Rasulo
BACKGROUND Lung protective strategies using low tidal volumes and moderate positive end expiratory pressures (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in acutely brain-injured patients due to concerns about carbon dioxide control and effect of PEEP on cerebral hemodynamic. METHODS In this multicenter, open-label, controlled clinical trial
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Up‐dosing of reslizumab in severe asthmatics with persistent sputum eosinophilia: A feasibility study Allergy (IF 12.6) Pub Date : 2024-09-17 Manali Mukherjee, Jaime Bernaola, Santi Nolasco, Melanie Kjarsgaard, Yinglan Xie, Katherine Radford, Bashayr Alotaibi, Carmen Venegas Garrido, Parameswaran Nair
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Synergistic Integration of mRNA-LNP with CAR-Engineered Immune Cells: Pioneering Progress in Immunotherapy. Mol. Ther. (IF 12.1) Pub Date : 2024-09-17 Zhaozhao Chen,Jinhui Shu,Yu Hu,Heng Mei
Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a revolutionary approach in the treatment of malignancies. Despite its remarkable successes, this field continues to grapple with challenges such as scalability, safety concerns, limited therapeutic effect, in vivo persistence, and the need for precise control over CAR expression. In the post-pandemic era of COVID-19 vaccine immunization
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Therapeutic CRISPR Epigenome Editing of Inflammatory Receptors in the Intervertebral Disc. Mol. Ther. (IF 12.1) Pub Date : 2024-09-17 Joshua D Stover,Matthew A R Trone,Jacob Weston,Christian Lewis,Hunter Levis,Niloofar Farhang,Matthew Philippi,Michelle Zeidan,Brandon Lawrence,Robby D Bowles
Low back pain (LBP) ranks among the leading causes of disability worldwide and generates a tremendous socioeconomic cost. Disc degeneration, a leading contributor to LBP, can be characterized by the breakdown of the extracellular matrix of the intervertebral disc (IVD), disc height loss, and inflammation. The inflammatory cytokine TNF-α has multiple signaling pathways, including proinflammatory signaling
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Hypermethylation and downregulation of microRNA219a-2 activates the ALDH1L2/GSH/PAI-1 pathway for fibronectin degradation in renal fibrosis. Mol. Ther. (IF 12.1) Pub Date : 2024-09-17 Qingqing Wei,Xiao Xiao,Emily Huo,Chunyuan Guo,Xiangjun Zhou,Xiaoru Hu,Charles Dong,Huidong Shi,Zheng Dong
Epigenetic regulations, such as DNA methylation and microRNAs, play an important role in renal fibrosis. Here, we report the regulation of microRNA-219a-2 by DNA methylation in fibrotic kidneys, unveiling the crosstalk between these epigenetic mechanisms. Through genome-wide DNA methylation analysis and pyro-sequencing, we detected the hypermethylation of microRNA219a-2 in renal fibrosis induced by
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Intranasal vaccination with engineered BCG expressing CCL2 induces a stronger immune barrier against Mycobacterium tuberculosis than BCG. Mol. Ther. (IF 12.1) Pub Date : 2024-09-17 Shaohua Guo,Jiangshan Ouyang,Zhiming Hu,Ting Cao,Chunxu Huang,Jun Mou,Xinxia Gu,Jie Liu
Intradermal Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccination is currently the only licensed strategy for preventing tuberculosis (TB). It provides limited protection against pulmonary TB. To enhance the efficacy of BCG, we developed a recombinant BCG expressing exogenous monocyte chemoattractant CC chemokine ligand 2 (CCL2), termed rBCG-CCL2. Co-culturing macrophages with rBCG-CCL2 enhances
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Toward life without sickle cell disease. Mol. Ther. (IF 12.1) Pub Date : 2024-09-17 Utpal P Davé,Jörg Bungert
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Immune responses to cells and proteins after hematopoietic stem cell gene therapy for inherited diseases: A cause for concern. Mol. Ther. (IF 12.1) Pub Date : 2024-09-17 Nathan Jeffreys,Robert Wynn
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VSTM2A reverses immunosuppression in colorectal cancer through antagonizing PD-L1/PD-1 interaction. Mol. Ther. (IF 12.1) Pub Date : 2024-09-17 Yujuan Dong,Jiaxun Jade Liu,Yunfei Zhou,Wei Kang,Shanglin Li,Alvin Hk Cheung,Hu Yi,Rui Liao,Nathalie Wong,Chi Chun Wong,Simon Ng,Jun Yu
Immunoglobulin VSTM2A is a top-ranked secretory protein that frequently silenced during colorectal carcinogenesis, however, its role in immune modulation remains largely unknown. Bioinformatic and immunohistochemistry analysis of human colorectal specimens and Vstm2a+/- knockout mice indicated that VSTM2A positively correlated with CD8a and immune infiltration in both physiological and pathological
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Macrophages overexpressing interleukin‐10 target and prevent atherosclerosis: Regression of plaque formation and reduction in necrotic core Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-09-17 Mingyi Wang, Shanshan Zhou, Yingyun Hu, Wei Tong, Hao Zhou, Mingrui Ma, Xingxuan Cai, Zhengbin Zhang, Luo Zhang, Yundai Chen
Atherosclerosis, a slowly progressing inflammatory disease, is characterized by the presence of monocyte‐derived macrophages. Interventions targeting the inflammatory characteristics of atherosclerosis hold promising potential. Although interleukin (IL)‐10 is widely acknowledged for its anti‐inflammatory effects, systemic administration of IL‐10 has limitations due to its short half‐life and significant
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Sintilimab combined with anlotinib and chemotherapy as second-line or later therapy in extensive-stage small cell lung cancer: a phase II clinical trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-16 Xiao Han, Jun Guo, Lingyu Li, Yong Huang, Xue Meng, Linlin Wang, Hui Zhu, Xiangjiao Meng, Qian Shao, Xing Li, Yan Zhang, Jin Wang, Yanhua Chen, Yingjie Zhang, Yiru Chen, Changbin Zhu, Zhehai Wang
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Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-16 Weiyi Yao, Xinting Hu, Xin Wang
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The case for inclusive co-creation in digital health innovation npj Digit. Med. (IF 12.4) Pub Date : 2024-09-16 Grace C. Nickel, Serena Wang, Jethro C. C. Kwong, Joseph C. Kvedar
This piece critiques the exclusion of healthcare practitioners (HCPs) from the digital health innovation process. Drawing on “Sync fast and solve things—best practices for responsible digital health” by Landers et al., the editorial argues for the importance of inclusive co-creation, in which clinicians play an active role in developing digital health solutions. It emphasizes that without the meaningful
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Deep behavioural representation learning reveals risk profiles for malignant ventricular arrhythmias npj Digit. Med. (IF 12.4) Pub Date : 2024-09-16 Maarten Z. H. Kolk, Diana My Frodi, Joss Langford, Tariq O. Andersen, Peter Karl Jacobsen, Niels Risum, Hanno L. Tan, Jesper Hastrup Svendsen, Reinoud E. Knops, Søren Zöga Diederichsen, Fleur V. Y. Tjong
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Non-viral targeted insertion of large payloads into T cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-16 Zsuzsanna Izsvák
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Unraveling the Complexities of Mesenchymal Stromal Cell-based Therapies: One Size Doesn't Fit All. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-15 Daniel J Weiss
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A randomized trial testing digital medicine support models for mild-to-moderate alcohol use disorder npj Digit. Med. (IF 12.4) Pub Date : 2024-09-14 Andrew Quanbeck, Ming-Yuan Chih, Linda Park, Xiang Li, Qiang Xie, Alice Pulvermacher, Samantha Voelker, Rachel Lundwall, Katherine Eby, Bruce Barrett, Randall Brown
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Variational Bayes machine learning for risk adjustment of general outcome indicators with examples in urology npj Digit. Med. (IF 12.4) Pub Date : 2024-09-14 Harvey Jia Wei Koh, Dragan Gašević, David Rankin, Stephane Heritier, Mark Frydenberg, Stella Talic
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Results and implications for generative AI in a large introductory biomedical and health informatics course npj Digit. Med. (IF 12.4) Pub Date : 2024-09-13 William Hersh, Kate Fultz Hollis
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One step at a time: new insights into double-stranded ribonucleic acid virus assembly Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-13 Virgile Rat, Alexander Borodavka, Don C. Lamb
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Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-13 Yunlong Shan, Mengying Zhang, Enxiang Tao, Jing Wang, Ning Wei, Yi Lu, Qing Liu, Kun Hao, Fang Zhou, Guangji Wang
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Long-term changes in wearable sensor data in people with and without Long Covid npj Digit. Med. (IF 12.4) Pub Date : 2024-09-13 Jennifer M. Radin, Julia Moore Vogel, Felipe Delgado, Erin Coughlin, Matteo Gadaleta, Jay A. Pandit, Steven R. Steinhubl
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Can social media encourage diabetes self-screenings? A randomized controlled trial with Indonesian Facebook users npj Digit. Med. (IF 12.4) Pub Date : 2024-09-13 Manuela Fritz, Michael Grimm, Ingmar Weber, Elad Yom-Tov, Benedictus Praditya
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Learning what keeps nanomedicines in tumours Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-13 Yifan Wang, Benjamin R. Schrank, Wen Jiang, Betty Y. S. Kim
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In situ formation of biomolecular condensates as intracellular drug reservoirs for augmenting chemotherapy Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-09-13 Tingxizi Liang, Yuxiang Dong, Irina Cheng, Ping Wen, Fengqin Li, Feng Liu, Qing Wu, En Ren, Peifeng Liu, Hongjun Li, Zhen Gu
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Inhibiting iNKT Cell Activation: A Promising Strategy Against Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-13 Taro Yasuma,Hajime Fujimoto,Corina N D'Alessandro-Gabazza,Esteban C Gabazza,Osamu Hataji,Tetsu Kobayashi
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Reply to Yasuma et al.: Inhibiting iNKT Cell Activation: A Promising Strategy Against Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-13 Adam J Byrne,Vipin Kumar,Albert Agro,Marc Hertz
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Temporal Exploration of COPD Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-13 Alexander J Bell,Sundaresh Ram,Wassim W Labaki,Susan Murray,Ella A Kazerooni,Stefanie Galban,Fernando J Martinez,Charles R Hatt,Jennifer M Wang,Vladimir Ivanov,Paul McGettigan,Edward Khokhlovich,Enrico Maiorino,Rahul Suryadevara,Adel Boueiz,Peter Castaldi,Evgeny M Mirkes,Andrei Zinovyev,Alexander N Gorban,Craig J Galban,MeiLan K Han
BACKGROUND Chronic obstructive pulmonary disease (COPD) exhibits considerable progression heterogeneity. We hypothesized that elastic principal graph analysis (EPGA) would identify distinct clinical phenotypes and their longitudinal relationships. METHODS Cross-sectional data from 8,972 tobacco-exposed COPDGene participants, with and without COPD, were used to train a model with EPGA, using thirty
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Expansion of phenotypically modified type 2 memory B cells after allergen immunotherapy Allergy (IF 12.6) Pub Date : 2024-09-13 Anouk von Borstel, Simone Reinwald, Pei M. Aui, Craig I. McKenzie, Nirupama Varese, P. Mark Hogarth, Mark Hew, Robyn E. O'Hehir, Menno C. van Zelm
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Letter to the editor: Efficacy of eHealth monitoring in pediatric asthma Allergy (IF 12.6) Pub Date : 2024-09-13 Casper E. W. Gijsen, Thijs R. P. Bogers, Jean W. M. Muris, Marieke W. P. van van Horck, Edward Dompeling
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A randomized controlled trial investigating experiential virtual reality communication on prudent antibiotic use npj Digit. Med. (IF 12.4) Pub Date : 2024-09-12 Adéla Plechatá, Guido Makransky, Robert Böhm
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Ethical debates amidst flawed healthcare artificial intelligence metrics npj Digit. Med. (IF 12.4) Pub Date : 2024-09-11 Jack Gallifant, Danielle S. Bitterman, Leo Anthony Celi, Judy W. Gichoya, Joao Matos, Liam G. McCoy, Robin L. Pierce
Healthcare AI faces an ethical dilemma between selective and equitable deployment, exacerbated by flawed performance metrics. These metrics inadequately capture real-world complexities and biases, leading to premature assertions of effectiveness. Improved evaluation practices, including continuous monitoring and silent evaluation periods, are crucial. To address these fundamental shortcomings, a paradigm
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The Road Less Traveled: Slow but Steady Progress Toward Cystic Fibrosis Gene Therapy by UK Respiratory Gene Therapy Consortium. Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-12 Terence R Flotte
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Are We Getting Closer to the "Cholesterol" for Chronic Respiratory Disease? Am. J. Respir. Crit. Care Med. (IF 19.3) Pub Date : 2024-09-12 David M Mannino,Jean Wright
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Effect of venom immunotherapy and sting challenge on HRQoL measured by venom‐allergy quality of life questionnaire (VQLQ) in Jack jumper ant allergic patients Allergy (IF 12.6) Pub Date : 2024-09-12 Kymble Spriggs, Elizabeth Leahy, Nicole Weibel, Sara Barnes
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Establishment of an ELISA‐based in vitro test system to quantify the major honey bee venom allergen Api m 10 in crude bee venoms and therapy allergen products Allergy (IF 12.6) Pub Date : 2024-09-12 Alisa Landgraf, Sascha Hein, Kathrin Elisabeth Paulus‐Tremel, Michelle Beatrice Wolff, Meike Arend, Ann‐Christine Junker, Daniel Strecker, Sascha Döring, Elke Völker, Thomas Holzhauser, Sandra Schmidt, Susanne Kaul, Stefan Schülke, Vera Mahler
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Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-11 Shen Wang, Wujian Li, Zhenshan Wang, Wanying Yang, Entao Li, Xianzhu Xia, Feihu Yan, Sandra Chiu
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Algorithms in allergy: Diagnosis and management of atopic dermatitis in adulthood Allergy (IF 12.6) Pub Date : 2024-09-11 M. Grace Hren, Ester Del Duca, Helen He, Andrew L. Ji, Emma Guttman‐Yassky
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Engineering a solution for allogeneic CAR-T rejection. Mol. Ther. (IF 12.1) Pub Date : 2024-09-11 Leila Amini,Lena Peter,Michael Schmueck-Henneresse
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Sex difference in human diseases: mechanistic insights and clinical implications Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2024-09-10 Yuncong Shi, Jianshuai Ma, Sijin Li, Chao Liu, Yuning Liu, Jie Chen, Ningning Liu, Shiming Liu, Hui Huang
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Understanding activity and physiology at scale: The Apple Heart & Movement Study npj Digit. Med. (IF 12.4) Pub Date : 2024-09-10 James Truslow, Angela Spillane, Huiming Lin, Katherine Cyr, Adeeti Ullal, Edith Arnold, Ron Huang, Laura Rhodes, Jennifer Block, Jamie Stark, James Kretlow, Alexis L. Beatty, Andreas Werdich, Deepali Bankar, Matt Bianchi, Ian Shapiro, Jaime Villalpando, Sharon Ravindran, Irida Mance, Adam Phillips, John Earl, Rahul C. Deo, Sumbul A. Desai, Calum A. MacRae
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Adherence to non-pharmaceutical interventions following COVID-19 vaccination: a federated cohort study npj Digit. Med. (IF 12.4) Pub Date : 2024-09-10 Benjamin Rader, Neil K. R. Sehgal, Julie Michelman, Stefan Mellem, Marinanicole D. Schultheiss, Tom Hoddes, Jamie MacFarlane, Geoff Clark, Shawn O’Banion, Paul Eastham, Gaurav Tuli, James A. Taylor, John S. Brownstein
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Closing the gap between open source and commercial large language models for medical evidence summarization npj Digit. Med. (IF 12.4) Pub Date : 2024-09-09 Gongbo Zhang, Qiao Jin, Yiliang Zhou, Song Wang, Betina Idnay, Yiming Luo, Elizabeth Park, Jordan G. Nestor, Matthew E. Spotnitz, Ali Soroush, Thomas R. Campion, Zhiyong Lu, Chunhua Weng, Yifan Peng