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Corrigendum to "Quantitative scoring of progression in transplant glomerulopathy using digital pathology may be superior to Banff cg scoring." Kidney International 2023;103:365-377. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Željko Kikić,Benjamin A Adam,Anna Buxeda,Carmen Lefaucheur,Alexandre Loupy,Heinz Regele,Daniel Cejka,Mark Haas,Robert B Colvin,Michael Mengel
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The Case | Dark dialysate after colonoscopy. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Arrsh Bajaj,Monica Arora,Udayan Bhatt
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CAPD catheter obstruction by fallopian tubes. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Yogita Sharma,Vaibhav Tiwari,Vipin Tyagi,Vinant Bhargava,Anurag Gupta,Manish Malik,Ashwani Gupta,Anil Bhalla,D S Rana
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Nephronophthisis-associated ciliopathy with brachydactyly, medullary cysts, and chronic kidney disease. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Way Loon Jonathan Chen,Kin Fen Kevin Fung,Eugene Yu-Hin Chan
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Anti-nephrin autoantibodies: novel predictors of post-transplant recurrence of focal segmental glomerular sclerosis. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Motoshi Hattori
Post-transplant recurrence of focal segmental glomerular sclerosis (FSGS) is a major challenge in the field of kidney transplantation. Currently, the most reliable predictor of FSGS recurrence is disease recurrence in a previous allograft. Recent studies suggest a possible causal role of anti-nephrin autoantibodies in the primary disease (primary FSGS and minimal change disease), as well as post-transplant
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Can plastics in urine serve as a noninvasive marker of systemic accumulation? Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Andrea Angeletti,Pasquale Esposito,Daniela Verzola,Paolo Cravedi,Edoardo La Porta
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NAVKIDS2: a lesson in matching outcome measures to interventions. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Rachel Willard-Grace,Delphine S Tuot
Patient navigator programs may improve outcomes among individuals with chronic kidney disease by reducing barriers to evidence-based care. The NAVKIDS2 trial evaluated a patient navigation program among 162 children with chronic kidney disease from marginalized populations. The intervention was not associated with quantitative changes in self-reported health, but qualitative data indicated substantial
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The renal function trajectory in clinical trial design: challenges and opportunities. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Steven Rosansky,Richard Glassock
The changes in renal function over time as surrogate endpoints for new drug trials are complicated by many factors, including the often-expected initial decrease in estimated glomerular filtration rate when a new drug is started. Two articles in the journal address this challenge, but multiple other challenges are explored in this commentary. To maximize the benefits of expensive new drugs that may
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Relmapirazin, a new exogenous filtration marker, and more widespread use of measured GFR. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Marcelle Tuttle,Andrew S Levey
Plasma or urinary clearance of exogenous filtration markers is required for assessment of measured glomerular filtration rate. Although multiple methods are available, none is widely used because of their complexity, each has measurement error, and standardization is limited. Recently, a study validated the plasma clearance of a new exogenous filtration marker, relmapirazin, which can be detected by
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Cilastatin, a new therapeutic promise for acute kidney injury. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 María Ángeles González-Nicolás,Alberto Lázaro
Acute kidney injury is a devasting clinical syndrome resulting from multiple causes, characterized by an abrupt deterioration of kidney function for which there is no pharmacologic treatment. Cilastatin has demonstrated direct nephroprotective effects in acute kidney injury and now is shown to be effective to specifically target therapeutically loaded nanoparticles to the proximal tubule to treat acute
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Elucidating the role of clonal hematopoiesis in acute kidney injury. Kidney Int. (IF 14.8) Pub Date : 2024-10-01 Yang Pan,Xiao Sun,Tanika N Kelly
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Production of Acetylcholine by Podocytes and its Protection from Kidney Injury in Glomerulonephritis. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-20 Luan D Truong,Jessica Trostel,Carlos Roncal,Gabriel Cara-Fuentes,Makoto Miyazaki,Shinobu Miyazaki-Anzai,Ana Andres-Hernando,Fumihiko Sasai,Miguel Lanaspa,Richard J Johnson,Gabriela E Garcia
BACKGROUND One of the most important factors modulating endothelial health is acetylcholine, and while it is associated as a cholinergic neurotransmitter; it is also expressed by non-neuronal cells. However, its role in the kidney, which does not receive cholinergic innervation, remains unknown. METHODS To determine if acetylcholine is produced in the kidney, we used ChAT(BAC)-eGFP (ChAT mice) transgenic
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Cardiac Localized Polycystin-2 in the Natriuretic Peptide Signaling Pathway and Hypertension. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-20 Karla M Márquez-Nogueras,Brandon Elliott,Paula Thuo,Elisabeth DiNello,Ryne M Knutila,Geena E Fritzmann,Virdjinija Vuchkovska,Sarah Flury,Monte Willis,Arlene B Chapman,Quan Cao,David Y Barefield,Ivana Y Kuo
BACKGROUND Hypertension is seen in 70% of autosomal dominant polycystic kidney disease (ADPKD) patients by the age of 30 prior to decline in kidney function. However, cardiac origins of hypertension, such as the natriuretic peptide signaling pathway, have not been fully investigated. We hypothesized that cardiomyocyte-localized polycystin proteins contribute to production of natriuretic peptides, and
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Posoleucel for BK Polyomavirus in Kidney Transplant Recipients. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-20 Maud Wilhelm,Anne Geng,Stefan Schaub,Hans H Hirsch
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In remembrance of Barry Morton Brenner, MD (1937–2024) Kidney Int. (IF 14.8) Pub Date : 2024-09-19 Joseph V. Bonventre, Giuseppe Remuzzi
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Metabolism at the crossroads of inflammation and fibrosis in chronic kidney disease Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-09-17 Verónica Miguel, Isaac W. Shaw, Rafael Kramann
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Unpicking the multi-omic response to endurance training: relevance for exercise benefits in chronic kidney disease. Kidney Int. (IF 14.8) Pub Date : 2024-09-18 Nicolette C Bishop
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ASN Kidney Health Guidance on the Management of Obesity in Persons Living with Kidney Diseases. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-18 T Alp Ikizler,Holly J Kramer,Srinivasan Beddhu,Alex R Chang,Allon N Friedman,Meera N Harhay,Elizabeth Yakes Jimenez,Brandon Kistler,Aleksandra Kukla,Kristin Larson,LindaMarie U Lavenburg,Sankar Dass Navaneethan,John Ortiz,Rocio I Pereira,David B Sarwer,Philip R Schauer,Evan M Zeitler,
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Identification of Nephrin Autoantibodies Signals New Chapter for Glomerular Disease. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2024-09-18 Clara J Fischman,Lawrence B Holzman
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A new mechanism in adrenal control of aldosterone secretion involving the macrophage and VEGF. Kidney Int. (IF 14.8) Pub Date : 2024-09-17 Tilman B Drueke,François Alhenc-Gelas
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SGLT2 inhibitors and kidney outcomes across the spectrum of kidney disease: a systematic review and meta-analysis Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-16 Bernardo F. Spiazzi, Giovana F. Piccoli, Laura F. Wayerbacher, João Pedro N. Lubianca, Bruno G. Scalco, Mariana H. Scheffler, Bruna L. Fraga, Verônica Colpani, Fernando Gerchman
aim to evaluate the effect of SGLT2 inhibitors on kidney outcomes across the Kidney Disease: Improving Global Outcomes (KDIGO) classification and urinary albumin-to-creatinine ratio (UACR) levels. Methods: We have searched MEDLINE (PubMed), EMBASE and the Cochrane Central Register of Controlled Trials from inception up to August 8th, 2023. In pairs, researchers selected large (≥500 subjects per arm)
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Polygenic scores and their applications in kidney disease Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-09-13 Atlas Khan, Krzysztof Kiryluk
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Social Connection: A Neglected Social Determinant of Health and an Opportunity to Improve Disease Management. Am. J. Kidney Dis. (IF 9.4) Pub Date : 2024-09-13 Sanya Tinaikar,Sarah J Schrauben
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Experiences of social isolation and loneliness in chronic kidney disease: a secondary qualitative analysis Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-09 Amanda Sluiter, Rosanna Cazzolli, Allison Jaure, Nicole Scholes-Robertson, Jonathan C Craig, David W Johnson, Andrea Matus Gonzalez, Benedicte Sautenet, Ben J Smith, Karine Manera, for the SONG initiative
ial isolation, to inform strategies to increase social participation. Methods: A secondary analysis of qualitative data from the Standardized Outcomes in Nephrology (SONG) initiative dataset (36 focus groups, three Delphi surveys and seven consensus workshops) was conducted. We extracted and thematically analyzed data from patients with CKD, including those receiving hemodialysis or peritoneal dialysis
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Symptom Burden and Altered Mineral Metabolism in Advanced Chronic Kidney Disease: Two Peas in a Pod Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-10 Orlando M. Gutiérrez
An abstract is unavailable.
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Associations of abnormal fluid status, plasma sodium disorders, and low dialysate sodium with mortality in hemodialysis patients Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-10 Jule Pinter, Bernard Canaud, Kaitlin J Mayne, Stefano Stuard, Ulrich Moissl, Jeroen Kooman, Kitty J Jager, Nicholas C Chesnaye, Brendan Smyth, Bernd Genser
The study followed 68,196 incident hemodialysis patients from 875 dialysis clinics in 25 countries over 10 years (2010-2020) investigating dose-response patterns between cumulative exposure time of fluid overload/depletion (measured by bioimpedance spectroscopy using the Fresenius Body Composition Monitor [BCM]), abnormal plasma sodium levels, low dialysate sodium, and all-cause mortality. We calculated
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Association of Neighborhood Social Determinants of Health with Acute Kidney Injury during Hospitalization Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-11 Lama Ghazi, Vibhu Parcha, Tomonori Takeuchi, Catherine R Butler, Elizabeth Baker, Gabriela R Oates, Lucia D Juarez, Ariann F Nassel, AKM Fazlur Rahman, Edward D. Siew, Xinyuan Chen, Orlando M Gutierrez, Javier A Neyra
lization. Methods: This is a retrospective cohort study of adults without end-stage kidney disease admitted to a large southern U.S. healthcare system from 10/2014 to 9/2017. Neighborhood SDOH measures included: 1) Socioeconomic status: Area Deprivation Index (ADI) scores, 2) Food access: Low Income Low Access (LILA) scores, 3) Rurality: Rural Urban Commuting Area (RUCA) scores, and (4) Residential
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Estimating glomerular filtration rate in kidney transplant recipients: considerations for selecting equations Kidney Int. (IF 14.8) Pub Date : 2024-09-12 Krishna A. Agarwal, Ogechi M. Adingwupu, Hocine Tighiouart, Shiyuan Miao, Marc Froissart, Michael Mauer, Wei Yang, Vicente Torres, Martin de Borst, Goran Klintmalm, Emilio D. Poggio, Peter Rossing, Ruben Velez, Anders Grubb, Andrew D. Rule, Kamran Shaffi, Ashtar Chami, Andrew S. Levey, Lesley A. Inker
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Phenotypes of Dialysis-Requiring Acute Kidney Injury and Associations with Mortality in a South American Population Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-12 Conrado Lysandro R. Gomes, Thais Lyra Cleto-Yamane, Patricia da Silva Fucuta, Heitor Blesa Farias, Frederico Ruzany, José Hermógenes Rocco Suassuna
iated with dialysis-requiring AKI (AKI-D) using latent class analysis (LCA) and examined the etiological spectrum and clinical phenotypes across different life stages. Methods: We analyzed 17,158 AKI-D patients from 170 medical facilities in Rio de Janeiro, Brazil (2002–2012). Utilizing survival curves and mixed-effects Cox regression for survival estimation, LCA classified patients based on clinical
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Bioimpedance-Guided Fluid Removal in Continuous Kidney Replacement Therapy: The VENUS Randomized Clinical Trial Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-12 Jung Nam An, Hyung Jung Oh, Sohee Oh, Harin Rhee, Eun Young Seong, Seon Ha Baek, Shin Young Ahn, Jang-Hee Cho, Jung Pyo Lee, Dong Ki Kim, Dong-Ryeol Ryu, Soyeon Ahn, Sejoong Kim
nagement for achieving estimated euvolemia (e-euvolemia) in CKRT-treated patients. Methods: In a multi-center randomized controlled trial from July 2017 to July 2020, the patients with AKI requiring CKRT were eligible if the weight at the start of CKRT had increased by ≥5% compared to the weight at the time of admission, or total body water (TBW)/ height (H)2 ≥13 L/m2. We randomly assigned 208 patients
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Ascites: Under- and Overfill: Is Amiloride the Answer? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-11 Detlef Bockenhauer,Giulia Florio
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Targeting APRIL in the treatment of glomerular diseases Kidney Int. (IF 14.8) Pub Date : 2024-09-07 Chee Kay Cheung, Jonathan Barratt, Richard Lafayette, Adrian Liew, Yusuke Suzuki, Vladimír Tesař, Hernán Trimarchi, Muh Geot Wong, Hong Zhang, Dana V. Rizk
A proliferation-inducing ligand (APRIL) is a key member of the tumor necrosis factor superfamily of cytokines and plays a central role in B-cell survival, proliferation, and Ig class switching. Recently, there has been increasing interest in the role of APRIL and the related cytokine B-cell activating factor in several glomerular diseases, because of their importance in the above processes. The therapeutic
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Comparative Effectiveness of Bisoprolol, Carvedilol, and Metoprolol Succinate in Patients with Heart Failure and Chronic Kidney Disease Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-06 Cheng-Wei Huang, Albert S. Yu, Hui Zhou, Katherine Pak, Sally F. Shaw, Jiaxiao Shi, Benjamin I. Broder, John J. Sim
An abstract is unavailable. This article is available as a PDF only.
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Intradialytic Hypotension in the Face of Using Different Antihypertensive Medication Classes Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-09-04 Csaba P. Kovesdy
An abstract is unavailable.
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The pathogenesis of IgA nephropathy and implications for treatment Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-09-04 Chee Kay Cheung, Suceena Alexander, Heather N. Reich, Haresh Selvaskandan, Hong Zhang, Jonathan Barratt
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Effects of Sodium-Glucose Cotransporter-2 Inhibitors on Kidney Outcomes across Baseline Cardiovascular-Kidney-Metabolic Conditions: A Systematic Review and Meta-Analyses. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-04 Tariq Jamal Siddiqi,David Cherney,Hasan Fareed Siddiqui,Tazeen H Jafar,James L Januzzi,Muhammad Shahzeb Khan,Adeera Levin,Nikolaus Marx,Janani Rangaswami,Jeffrey Testani,Muhammad Shariq Usman,Christoph Wanner,Faiez Zannad,Javed Butler
BACKGROUND The effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on kidney outcomes in patients with varying combinations of heart failure, chronic kidney disease, and type 2 diabetes mellitus have not been quantified. METHODS PubMed and Scopus were queried up to December 2023 for primary and secondary analysis of placebo-controlled trials of SGLT2i in patients with heart failure, chronic
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Endothelin Receptor Antagonists Plus Sodium-Glucose Cotransporter 2 Inhibitors: Poster Child for a New ERA of Combination Therapies? J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-04 Christine P Limonte,Ian H de Boer
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Race-and Ethnicity-Related Disparities in Predialysis Nephrology Care, Kidney Disease Education, and Home Dialysis Utilization. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-04 Ashutosh M Shukla,Grant Scheiffele,Wenxi Huang,Rebecca Campbell-Montalvo,Bian Jiang,Yi Guo,Serena Jingchuan Guo
BACKGROUND Pre-dialysis nephrology care and kidney replacement therapy (KRT)-directed education (KDE) are essential for incident home dialysis use. However, there are substantial disparities in these care parameters among patients with advanced CKD. The impact of these disparities on home dialysis underuse has not been examined. METHODS We analyzed the 2021 US Renal Database System to identify all
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A novel mechanism of sodium and fluid retention in liver disease Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-09-03 Ellen F. Carney
In patients with liver disease, sodium and fluid retention is often attributed to reduced effective blood volume, which stimulates the renin–angiotensin–aldosterone system (RAAS). However, not all patients show RAAS activation. New data suggest a potential aldosterone-independent mechanism of sodium and fluid retention in liver disease. The researchers conclude that activation of ENaC by bile acids
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Glycolysis in Peritubular Endothelial Cells and Microvascular Rarefaction in CKD. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-03 Yujie Huang,Ansheng Cong,Jinjin Li,Zhanmei Zhou,Hong Zhou,Cailing Su,Zuoyu Hu,Fan Fan Hou,Wei Cao
BACKGROUND Peritubular endothelial cell dropout leading to microvascular rarefaction is a common manifestation of chronic kidney disease (CKD). The role of metabolism reprogramming in peritubular endothelial cell loss in CKD is undetermined. METHODS Single-cell sequencing and metabolic analysis were used to characterize metabolic profile of peritubular endothelial cells from CKD patients and from CKD
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Targeting Metabolic Reprogramming in Polycystic Kidney Disease. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-03 Alessandra Boletta
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Opioid Prescriptions for US Patients Undergoing Long-Term Dialysis or with Kidney Transplant from 2011 to 2020. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-09-03 Paul L Kimmel,Chyng-Wen Fwu,Thomas D Nolin,Ivonne H Schulman,Shannon S Givens,Kenneth Wilkins,Susan Mendley,Debbie S Gipson,Raquel C Greer,Jenna M Norton,Kevin E Chan,Paul W Eggers
BACKGROUND Pain is important for patients with kidney failure, but opioid medication prescriptions are associated with morbidity and mortality. The Centers for Disease Control and Prevention issued opioid prescription guidelines in 2016 and 2022, associated with dramatically decreased prescription rates in the United States. It is critical to know if nationwide opioid prescription rates for patients
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Reference-trial-informed design to explore treatment effects in trial-underrepresented subgroups Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-09-02 Paris J. Baptiste
Randomized controlled trials (RCT) are often regarded as the ‘gold standard’ of clinical evidence. However, their strict eligibility criteria can impact cohort diversity and limit the inclusion of some subgroups, including patients with comorbidities, older individuals or those from minority ethnic groups. Observational data, including data from electronic health records, can be used to bridge the
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Targeted gene therapy for rare genetic kidney diseases. Kidney Int. (IF 14.8) Pub Date : 2024-08-31 Veenita Khare,Stephanie Cherqui
Chronic kidney disease (CKD) is one of the leading causes of mortality worldwide because of kidney failure and the associated challenges of its treatment including dialysis and kidney transplantation. About one-third of CKD cases are linked to inherited monogenic factors, making them suitable for potential gene therapy interventions. However, the intricate anatomical structure of the kidney poses a
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The Association Between Residential Segregation and Access to Kidney Transplantation – Evidence from a Multi-State Cohort Study Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-08-26 Jasmine Berry, Aubriana Perez, Mengyu Di, Chengcheng Hu, Stephen O. Pastan, Rachel E Patzer, Jessica L Harding
(n = 42,401; 18-80 years) with ESKD initiating kidney replacement therapy (KRT) in three US States (Georgia, North Carolina, South Carolina) between January 2015 and December 2019, with follow-up through 2020, from the United States Renal Data System (USRDS). Residential segregation was defined using the racial Index of Concentration at the Extremes and classified into tertiles (predominantly Black
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Urinary Response to Consuming Plant-Based Meat Alternatives in Persons with Normal Kidney Function: The SWAP-MEAT Pilot Trial Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-08-26 Catherine P. Ward, Matthew J. Landry, Kristen M. Cunanan, Kalani L. Raphael, Christopher C. Dant, Christopher D. Gardner, Alan C. Pao
nefits as eating whole vegetables. We hypothesized that eating plant-meat when compared with animal meat decreases dietary acid load but increases dietary phosphorus and nitrogen. Methods: SWAP-MEAT was a randomized eight-week, crossover trial (NCT03718988) of participants consuming >2 servings/day of either plant-meat or animal meat for each eight-week phase. We measured urine sulfate, ammonium, pH
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Towards an effective obstetric nephrology care: the Mansoura experience Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-08-29 Rasha Shemies
For women with kidney disease of childbearing age, kidney care should feature discussions of pregnancy, including informed counseling and support. Health disparities between regions with different levels of income are undeniable, but special care programs aimed at the early identification and management of patients at risk can greatly decrease the magnitude of the problem.
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Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity. Kidney Int. (IF 14.8) Pub Date : 2024-08-31 Florian Grahammer,Bernhard Dumoulin,Ramila E Gulieva,Hui Wu,Yaoxian Xu,Nurgazy Sulaimanov,Frederic Arnold,Lukas Sandner,Tomke Cordts,Abhijeet Todkar,Pierre Moulin,Wilfried Reichardt,Victor G Puelles,Rafael Kramann,Benjamin S Freedman,Hauke Busch,Melanie Boerries,Gerd Walz,Tobias B Huber
Progression of cystic kidney disease has been linked to activation of the mTORC1 signaling pathway. Yet the utility of mTORC1 inhibitors to treat patients with polycystic kidney disease remains controversial despite promising preclinical data. To define the cell intrinsic role of mTORC1 for cyst development, the mTORC1 subunit gene Raptor was selectively inactivated in kidney tubular cells lacking
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A randomized phase 2b trial examined the effects of the glucagon-like peptide-1 and glucagon receptor agonist cotadutide on kidney outcomes in patients with diabetic kidney disease. Kidney Int. (IF 14.8) Pub Date : 2024-08-30 Viknesh Selvarajah,Darren Robertson,Lars Hansen,Lutz Jermutus,Kirsten Smith,Angela Coggi,José Sánchez,Yi-Ting Chang,Hongtao Yu,Joanna Parkinson,Anis Khan,H Sophia Chung,Sonja Hess,Richard Dumas,Tabbatha Duck,Simran Jolly,Tom G Elliott,John Baker,Albert Lecube,Karl-Michael Derwahl,Russell Scott,Cristobal Morales,Carl Peters,Ronald Goldenberg,Victoria E R Parker,Hiddo J L Heerspink,
Cotadutide is a glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist that may improve kidney function in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). In this phase 2b study, patients with T2D and CKD ,estimated glomerular filtration rate [eGFR] of 20 or more and under 90 mL/min per 1.73 m2 and urinary albumin-to-creatinine ratio [UACR] over 50 mg/g) were randomized
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Myeloperoxidase-ANCA IgG induces different forms of small vessel vasculitis based on type of synergistic immune stimuli Kidney Int. (IF 14.8) Pub Date : 2024-08-30 Peiqi Hu, Hong Xiao, Marco A. Alba, Hannah M. Atkins, Shenju Gou, Yanglin Hu, John C. Gomez, Corey M. Jania, Jessica R. Martin, Thomas E. Morrison, Stephen L. Tilley, Mark T. Heise, Claire M. Doerschuk, Ronald J. Falk, J. Charles Jennette
Anti-neutrophil cytoplasmic autoantibody (ANCA) vasculitis has diverse patterns of injury including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA). Necrotizing and crescentic glomerulonephritis (NCGN) occurs in all syndromes and as renal limited vasculitis (RLV). Single-dose intravenous ANCA IgG-specific for mouse myeloperoxidase
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Where Are Patients’ Voices in Chronic Kidney Disease? Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-08-30 Despina Rüssmann, Prabir Roy-Chaudhury, Glenn M. Chertow, Patrick Gee, Cynthia Chauhan, Steven Macari, Michael Murphy, Patrick Rossignol
An abstract is unavailable. This article is available as a PDF only.
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A randomized, open-label, clinical trial examined the effects of canagliflozin on albuminuria and eGFR decline using an individual pre-intervention eGFR slope. Kidney Int. (IF 14.8) Pub Date : 2024-08-30 Satoshi Miyamoto,Hiddo J L Heerspink,Dick de Zeeuw,Kota Sakamoto,Michihiro Yoshida,Masao Toyoda,Daisuke Suzuki,Takashi Hatanaka,Tohru Nakamura,Shinji Kamei,Satoshi Murao,Kazuyuki Hida,Shinichiro Ando,Hiroaki Akai,Yasushi Takahashi,Munehiro Kitada,Hisashi Sugano,Tomokazu Nunoue,Akihiko Nakamura,Motofumi Sasaki,Tatsuaki Nakatou,Kei Fujimoto,Daiji Kawanami,Takashi Wada,Nobuyuki Miyatake,Hiromi Kuramoto
Demonstrating drug efficacy in slowing kidney disease progression requires large clinical trials when targeting participants with an early stage of chronic kidney disease (CKD). In this randomized, parallel-group, open-labeled trial (CANPIONE study), we assessed the effect of the sodium-glucose cotransporter 2 (SGLT2) inhibitor canagliflozin using the individual's change in estimated glomerular filtration
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Chronic endothelial dopamine receptor stimulation improves endothelial function and hemodynamics in autosomal dominant polycystic kidney disease. Kidney Int. (IF 14.8) Pub Date : 2024-08-29 Audrey Dumont,Mouad Hamzaoui,Déborah Groussard,Michèle Iacob,Dominique Bertrand,Isabelle Remy-Jouet,Mélanie Hanoy,Frank Le Roy,Laurence Chevalier,Christoph Enzensperger,Hans-Dieter Arndt,Sylvanie Renet,Anaïs Dumesnil,Emilie Lévêque,Thomas Duflot,Valéry Brunel,Aurore Michel-Després,Marie-Pierre Audrézet,Vincent Richard,Robinson Joannidès,Dominique Guerrot,Jérémy Bellien
Altered polycystin-mediated endothelial flow mechanosensitivity contributes to the development of hypertension and cardiovascular complications in patients with autosomal dominant polycystic kidney disease (ADPKD). Stimulation of endothelial type 5 dopamine receptors (DR5) can acutely compensate for the endothelial consequences of polycystin deficiency, but the chronic impact of this approach must
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Paracellular Transport and Renal Tubule Calcium Handling: Emerging Roles in Kidney Stone Disease. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-08-29 Alan S L Yu,Joshua N Curry
The kidney plays a major role in maintenance of serum calcium concentration, which must be kept within a narrow range to avoid disruption of numerous physiologic processes that depend critically on the level of extracellular calcium, including cell signaling, bone structure, and muscle and nerve function. This defense of systemic calcium homeostasis comes, however, at the expense of the dumping of
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Integrity of the Glomerular Filtration Barrier: The Impact of Adhesion G-Protein-Coupled Receptor F5 on Glomerular Endothelial Cells. J. Am. Soc. Nephrol. (IF 10.3) Pub Date : 2024-08-29 Ubong S Ekperikpe,Ilse S Daehn
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Comparison of obinutuzumab and rituximab for treating primary membranous nephropathy Clin. J. Am. Soc. Nephrol. (IF 8.5) Pub Date : 2024-08-29 Xiaofan Hu, Muyin Zhang, Jing Xu, Chenni Gao, Xialian Yu, Xiao Li, Hong Ren, Weiming Wang, Jingyuan Xie
tration rate (eGFR) ≥30 mL/min/1.73 m2 despite six months of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker and treatment with obinutuzumab or rituximab were included and matched by propensity score (ratio: 1:2) based on age, sex, urine protein, eGFR, and titers of Anti-Phospholipase A2 receptor (PLA2R) antibody. The primary outcome was defined as a combination of partial or
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Amino acid metabolism in kidney health and disease Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-08-28 Martine G. E. Knol, Vera C. Wulfmeyer, Roman-Ulrich Müller, Markus M. Rinschen
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NOX2 dampens TLR7 to protect the kidneys in SLE Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-08-27 Monica Wang
Lupus nephritis (LN) is a common clinical complication in patients with systemic lupus erythematosus (SLE). A report by Mark J. Shlomchik and colleagues reveals an interplay between NADPH oxidase 2 (NOX2) and Toll-like receptor 7 (TLR7) in B cells that can modulate SLE severity, including its kidney manifestations. The researchers propose that this protection might result from NOX2-mediated inhibition
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Microglial activation in CKD-associated cognitive decline Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-08-27 Susan J. Allison
Cognitive decline is common in patients with chronic kidney disease (CKD); however, the mechanisms linking these two conditions is unclear. New research suggests that disruption of the blood–brain barrier (BBB) by uraemic toxins may lead to microglial activation and subsequent IL-1 receptor (IL-1R)-mediated neuronal impairment. Exposure of neurons to plasma from patients with CKD did not induce their
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The roles of hyaluronan in kidney development, physiology and disease Nat. Rev. Nephrol. (IF 28.6) Pub Date : 2024-08-27 Ton J. Rabelink, Gangqi Wang, Johan van der Vlag, Bernard M. van den Berg